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7. What is the impact of stromal microinvasion on oncologic outcomes in borderline ovarian tumors? A multicenter case–control study

Author

Boyraz, Gokhan, Salman, Mehmet Coskun, Gultekin, Murat, Ozkan, Nazlı Topfedaisi, Uckan, Hasan H., Gungorduk, Kemal, Gulseren, Varol, Ayik, Hulya, Toptas, Tayfun, Kuru, Oguzhan, Sozen, Hamdullah, Erturk, Anıl, Ozgul, Nejat, Meydanlı, Mehmet Mutlu, Sanci, Muzaffer, Turan, Taner, Gungor, Tayfun, Simsek, Tayup, Topuz, Samet, and Yuce, Kunter

Published
2017
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15. Could the Long-Term Oncological Safety of Laparoscopic Surgery in Low-Risk Endometrial Cancer also Be Valid for the High–Intermediate- and High-Risk Patients? A Multi-Center Turkish Gynecologic Oncology Group Study Conducted with 2745 Endometrial Cancer Cases. (TRSGO-End-001)

Author

Vardar, Mehmet Ali, primary, Guzel, Ahmet Baris, additional, Taskin, Salih, additional, Gungor, Mete, additional, Ozgul, Nejat, additional, Salman, Coskun, additional, Kucukgoz-Gulec, Umran, additional, Khatib, Ghanim, additional, Taskiran, Cagatay, additional, Dünder, Ilkkan, additional, Ortac, Firat, additional, Yuce, Kunter, additional, Terek, Cosan, additional, Simsek, Tayup, additional, Ozsaran, Aydın, additional, Onan, Anil, additional, Coban, Gonca, additional, Topuz, Samet, additional, Demirkiran, Fuat, additional, Takmaz, Ozguc, additional, Kose, M. Faruk, additional, Gocmen, Ahmet, additional, Seydaoglu, Gulsah, additional, Gumurdulu, Derya, additional, and Ayhan, Ali, additional

Published
2021
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26. Multi-institutional validation of the ESMO-ESGO-ESTRO consensus conference risk grouping in Turkish endometrial cancer patients treated with comprehensive surgical staging

Author

Gultekin, Melis, primary, Guler, Ozan Cem, additional, Yuce Sari, Sezin, additional, Akkus Yildirim, Berna, additional, Onal, Cem, additional, Celik, Husnu, additional, Yuce, Kunter, additional, Ayhan, Ali, additional, Arik, Zafer, additional, Kose, Fatih, additional, Altundag, Ozden, additional, Zoto Mustafayev, Teuta, additional, Atalar, Banu, additional, Bolukbasi, Yasemin, additional, and Yildiz, Ferah, additional

Published
2020
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34. Lymph node metastasis in grossly apparent clinical stage Ia epithelial ovarian cancer: Hacettepe experience and review of literature

Author

Yuce Kunter, Usubutun Alp, Gultekin Murat, Desteli Guldeniz, and Ayhan Ali

Subjects
Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Lymphadenectomy is an integral part of the staging system of epithelial ovarian cancer. However, the extent of lymphadenectomy in the early stages of ovarian cancer is controversial. The objective of this study was to identify the lymph node involvement in unilateral epithelial ovarian cancer apparently confined to the one ovary (clinical stage Ia). Methods A prospective study of clinical stage I ovarian cancer patients is presented. Patient's characteristics and tumor histopathology were the variables evaluated. Results Thirty three ovarian cancer patients with intact ovarian capsule were evaluated. Intraoperatively, neither of the patients had surface involvement, adhesions, ascites or palpable lymph nodes (supposed to be clinical stage Ia). The mean age of the study group was 55.3 ± 11.8. All patients were surgically staged and have undergone a systematic pelvic and paraaortic lymphadenectomy. Final surgicopathologic reports revealed capsular involvement in seven patients (21.2%), contralateral ovarian involvement in two (6%) and omental metastasis in one (3%) patient. There were two patients (6%) with lymph node involvement. One of the two lymph node metastasis was solely in paraaortic node and the other metastasis was in ipsilateral pelvic lymph node. Ovarian capsule was intact in all of the patients with lymph node involvement and the tumor was grade 3. Conclusion In clinical stage Ia ovarian cancer patients, there may be a risk of paraaortic and pelvic lymph node metastasis. Further studies with larger sample size are needed for an exact conclusion.

Published
2010
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36. Multi-institutional validation of the ESMO-ESGO-ESTRO consensus conference risk grouping in Turkish endometrial cancer patients treated with comprehensive surgical staging.

Author

Gultekin, Melis, Guler, Ozan Cem, Yuce Sari, Sezin, Akkus Yildirim, Berna, Onal, Cem, Celik, Husnu, Yuce, Kunter, Ayhan, Ali, Arik, Zafer, Kose, Fatih, Altundag, Ozden, Zoto Mustafayev, Teuta, Atalar, Banu, Bolukbasi, Yasemin, and Yildiz, Ferah

Subjects
ENDOMETRIAL cancer, ENDOMETRIAL surgery, EXTERNAL beam radiotherapy, OVERALL survival, CANCER patients, SURGICAL margin, UTERINE surgery, RESEARCH, RESEARCH evaluation, RESEARCH methodology, GYNECOLOGY, CANCER relapse, MEDICAL cooperation, EVALUATION research, RISK assessment, UTERUS, TREATMENT effectiveness, TUMOR classification, COMPARATIVE studies, ENDOMETRIAL tumors, RADIOTHERAPY, RADIOISOTOPE brachytherapy, ONCOLOGY, TUMOR grading, MEDICAL societies, STANDARDS
Abstract

In this study, 683 patients with endometrial cancer (EC) after comprehensive surgical staging were classified into four risk groups as low (LR), intermediate (IR), high-intermediate (HIR) and high-risk (HR), according to the recent consensus risk grouping. Patients with disease confined to the uterus, ≥50% myometrial invasion (MI) and/or grade 3 histology were treated with vaginal brachytherapy (VBT). Patients with stage II disease, positive/close surgical margins or extra-uterine extension were treated with external beam radiotherapy (EBRT)±VBT. The median follow-up was 56 months. The overall survival (OS) was significantly different between LR and HR groups, and there was a trend between LR and HIR groups. Relapse-free survival (RFS) was significantly different between LR and HIR, LR and HR and IR and HR groups. There was no significant difference in OS and RFS rates between the HIR and HR groups. In HR patients, the OS and RFS rates were significantly higher in stage IB - grade 3 and stage II compared to stage III and non-endometrioid histology without any difference between the two uterine-confined stages and between stage III and non-endometrioid histology. The current risk grouping does not clearly discriminate the HIR and IR groups. In patients with comprehensive surgical staging, a further risk grouping is needed to distinguish the real HR group.Impact statementWhat is already known on this subject? The standard treatment for endometrial cancer (EC) is surgery and adjuvant radiotherapy (RT) and/or chemotherapy is recommended according to risk factors. The recent European Society for Medical Oncology (ESMO), European Society of Gynaecological Oncology (ESGO) and European Society for Radiotherapy and Oncology (ESTRO) guideline have introduced a new risk group. However, the risk grouping is still quite heterogeneous.What do the results of this study add? This study demonstrated that the current risk grouping recommended by ESMO-ESGO-ESTRO does not clearly discriminate the intermediate risk (IR) and high-intermediate risk (HIR) groups.What are the implications of these findings for clinical practice and/or further research? Based on the results of this study, a new risk grouping can be made to discriminate HIR and IR groups clearly in patients with comprehensive surgical staging. [ABSTRACT FROM AUTHOR]

Published
2021
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39. Widespread Recurrence 7 Years after Radical Abdominal Trachelectomy for Early Cervical Adenocarcinoma

Author

Salman, M. Coskun, Ozgul, Nejat, and Yuce, Kunter

Subjects
Article Subject
Abstract

Cervical cancer is the third most common female cancer worldwide and the use of routine screening resulted in earlier stage and younger age at diagnosis. Fertility preservation via radical trachelectomy comes up as an option in such patients. Recent literature reviews confirm the safety of this operation with excellent oncologic outcomes in appropriately chosen patients. However, recurrent disease is likely and a strict follow-up is recommended to detect recurrences at an early stage following radical trachelectomy. In this report, a case who underwent radical trachelectomy and developed widespread recurrences 7 years after initial surgery possibly due to the lack of oncologic follow-up is discussed.

Published
2015
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43. Extrauterine Spread, Adjuvant Treatment, and Prognosis in Noninvasive Uterine Papillary Serous Carcinoma of the Endometrium: A Retrospective Multicenter Study

Author

Boyraz, Gokhan, primary, Salman, Mehmet Coskun, additional, Basaran, Derman, additional, Ozgul, Nejat, additional, Turan, Taner, additional, Turkmen, Osman, additional, Kimyon, Gunsu Comert, additional, Ozkan, Nazli Topfedaisi, additional, Cagan, Murat, additional, Gungor, Tayfun, additional, Meydanli, Mehmet Mutlu, additional, Gungorduk, Kemal, additional, Gulseren, Varol, additional, Sanci, Muzaffer, additional, and Yuce, Kunter, additional

Published
2016
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49. Multicenter Analysis of Gestational Trophoblastic Neoplasia in Turkey

Author

Ozalp, Sabit Sinan, primary, Telli, Elcin, additional, Oge, Tufan, additional, Tulunay, Gokhan, additional, Boran, Nurettin, additional, Turan, Taner, additional, Yenen, Mufit, additional, Kurdoglu, Zehra, additional, Ozler, Ali, additional, Yuce, Kunter, additional, Ulker, Volkan, additional, Arvas, Macit, additional, Demirkiran, Fuat, additional, Bese, Tugan, additional, Tokgozoglu, Nedim, additional, Onan, Anil, additional, Sanci, Muzaffer, additional, Gokcu, Mehmet, additional, Tosun, Gokhan, additional, Dikmen, Yilmaz, additional, Ozsaran, Aydin, additional, Terek, Mustafa Cosan, additional, Akman, Levent, additional, Yetimalar, Hakan, additional, Kilic, Derya Sakarya, additional, Gungor, Tayfun, additional, Ozgu, Emre, additional, Yildiz, Yunus, additional, Kokcu, Arif, additional, Kefeli, Mehmet, additional, Kuruoglu, Serkan, additional, Yuksel, Hasan, additional, Guvenal, Tevfik, additional, Hasdemir, Pinar Solmaz, additional, Ozcelik, Bulent, additional, Serin, Serdar, additional, Dolanbay, Mehmet, additional, Arioz, Dagistan Tolga, additional, Tuncer, Nadire, additional, Bozkaya, Hasan, additional, Guven, Suleyman, additional, Kulaksiz, Deniz, additional, Varol, Fusun, additional, Ali, Yanik, additional, Ogurlu, Gonca, additional, Simsek, Tayyup, additional, Toptas, Tayfun, additional, Dogan, Selen, additional, Camuzoglu, Hakan, additional, Api, Murat, additional, Guzin, Kadir, additional, Eray, Caliskan, additional, and Doger, Emek, additional

Published
2014
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50. HPV types in Turkey: multicenter hospital based evaluation of 6388 patients in turkish gynecologic oncology group centers

Author

Dursun, Polat, primary, Ayhan, Ali, additional, Mutlu, Levent, additional, Caglar, Mete, additional, Haberal, Ali, additional, Gungor, Taygun, additional, Ozat, Mustafa, additional, Ozgu, Emre, additional, Onan, Anil, additional, Taskiran, Cagatay, additional, Guner, Haldun, additional, Yetimalar, Hakan, additional, Kasap, Burcu, additional, Yuce, Kunter, additional, Salman, M. Coskun, additional, Sayal, Berkan, additional, Dogan, Selen, additional, Harma, Muge, additional, Harma, Mehmet, additional, Basaran, Mustafa, additional, Aydogmus, Huseyin, additional, Ergun, Yusuf, additional, Sehirali, Salim, additional, Gultekin, Emre, additional, Kose, Sukran, additional, Yildirim, Yusuf, additional, Yenen, Mufit, additional, Dede, Murat, additional, Alanbay, Ibrahim, additional, Karaca, Riza, additional, Metindir, Jale, additional, Keskin, Levent, additional, Ustuner, Isik, additional, Avsar, Filiz, additional, Yuksel, Hasan, additional, and Kirdar, Selim, additional

Published
2013
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