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1,035 results on '"Wang, Jinghan"'

2. Detection of morphine and data processing using surface plasmon resonance imaging sensor

Author

Sun Jianuo, Ke Haokun, Wang Jinghan, Du Xianchao, Hao Hongxia, and Zhou Hong

Subjects
spri, inhibition immunoassay, morphine, calibration curve, Chemistry, QD1-999
Abstract

Based on the surface plasmon resonance imaging (SPRi) instrument, we established a new method of analyzing morphine in urine by processing a calibration curve. According to an inhibition immunoassay, gradient concentration of morphine and morphine-BSA fixed on the chip competitively combine with morphine antibody on the chip. Given the three mathematical models, the data of SPRi signals generated from SPRi with morphine was processed to obtain the calibration curve. Ultrafiltration was used to pretreat blank urine samples with adding morphine, and then investigated the advantages and disadvantages of each model. With a limit detection of 6.57 ng·mL−1, the method and mathematical models can provide robust support for SPRi sensors used in further environmental detection, such as the epidemiological study of sewage.

Published
2024
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8. Near Sample-Optimal Reduction-based Policy Learning for Average Reward MDP

Author

Wang, Jinghan, Wang, Mengdi, and Yang, Lin F.

Subjects
Computer Science - Machine Learning, Computer Science - Artificial Intelligence
Abstract

This work considers the sample complexity of obtaining an $\varepsilon$-optimal policy in an average reward Markov Decision Process (AMDP), given access to a generative model (simulator). When the ground-truth MDP is weakly communicating, we prove an upper bound of $\widetilde O(H \varepsilon^{-3} \ln \frac{1}{\delta})$ samples per state-action pair, where $H := sp(h^*)$ is the span of bias of any optimal policy, $\varepsilon$ is the accuracy and $\delta$ is the failure probability. This bound improves the best-known mixing-time-based approaches in [Jin & Sidford 2021], which assume the mixing-time of every deterministic policy is bounded. The core of our analysis is a proper reduction bound from AMDP problems to discounted MDP (DMDP) problems, which may be of independent interests since it allows the application of DMDP algorithms for AMDP in other settings. We complement our upper bound by proving a minimax lower bound of $\Omega(|\mathcal S| |\mathcal A| H \varepsilon^{-2} \ln \frac{1}{\delta})$ total samples, showing that a linear dependent on $H$ is necessary and that our upper bound matches the lower bound in all parameters of $(|\mathcal S|, |\mathcal A|, H, \ln \frac{1}{\delta})$ up to some logarithmic factors.

Published
2022

38. AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial

Author

Lv, Jun, Wang, Hui, Cheng, Xiaoting, Chen, Yuxin, Wang, Daqi, Zhang, Longlong, Cao, Qi, Tang, Honghai, Hu, Shaowei, Gao, Kaiyu, Xun, Mengzhao, Wang, Jinghan, Wang, Zijing, Zhu, Biyun, Cui, Chong, Gao, Ziwen, Guo, Luo, Yu, Sha, Jiang, Luoying, Yin, Yanbo, Zhang, Jiajia, Chen, Bing, Wang, Wuqing, Chai, Renjie, Chen, Zheng-Yi, Li, Huawei, and Shu, Yilai

Published
2024
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46. Totally laparoscopic associating simultaneous bile duct and portal vein ligation for planned hepatectomy for primary liver cancer: a case report

Author

Wang Jinghan, Ao Jianyang, Ma Wencong, and Liu Chen

Subjects
Primary liver cancer, Portal vein, Bile duct, Ligation, Case report, Medicine
Abstract

Abstract Background Some patients with liver cancer lose the chance to have surgical treatment due to insufficient future remnant liver. To address this problem, individual or occlusion of both the portal vein and the bile duct was used to achieve quick hypertrophy. This is the first study reported in which simultaneous ligation of the portal vein and the bile duct was applied as the first step of planned hepatectomy of primary liver cancer. Case presentation Here we report a case of a 38-year-old Asian male patient with hepatocellular carcinoma with tumor thrombus in the right anterior branch of the portal vein. Right hemihepatectomy can be curative, but patients face a high risk of liver failure because of the small volume of the remaining left liver lobe. Hence we developed a two-step liver resection strategy in which the patient underwent laparoscopic simultaneous bile duct and portal vein ligation of the right hepatic lobe prior to right hemihepatectomy under laparoscopy. Using this procedure, we achieved fast hypertrophy of the left liver lobe and successfully reversed the primary unresectability. Conclusion This case report demonstrates that simultaneous bile duct and portal vein ligation may be a feasible option for those patients with liver cancer who cannot get surgical treatment due to insufficient future remnant liver.

Published
2023
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