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3. Monitoring monocyte HLA-DR expression and CD4 + T lymphocyte count in dexamethasone-treated severe COVID-19 patients

Author

Monneret, Guillaume, Voirin, Nicolas, Richard, Jean-Christophe, Cour, Martin, Rimmelé, Thomas, Garnier, Lorna, Yonis, Hodane, Coudereau, Remy, Gossez, Morgane, Malcus, Christophe, Wallet, Florent, Delignette, Marie-Charlotte, Dailler, Frederic, Buisson, Marielle, Argaud, Laurent, Lukaszewicz, Anne-Claire, and Venet, Fabienne

Published
2024
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5. Clinical description and outcome of overall varicella-zoster virus-related organ dysfunctions admitted in intensive care units: the VAZOREA cohort study

Author

Malherbe, Jolan, Godard, Pierre, Lacherade, Jean-Claude, Coirier, Valentin, Argaud, Laurent, Hyvernat, Hervé, Schneider, Francis, Charpentier, Julien, Wallet, Florent, Pocquet, Juliette, Plantefeve, Gaëtan, Quenot, Jean-Pierre, Bay, Pierre, Delbove, Agathe, Georges, Hugues, Urbina, Tomas, Schnell, David, Le Moal, Charlène, Stanowski, Matthieu, Muris, Corentin, Jonas, Maud, Sauneuf, Bertrand, Lesieur, Olivier, Lhermitte, Amaury, Calvet, Laure, Gueguen, Ines, and du Cheyron, Damien

Published
2024
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6. Comparison of mortality and outcomes of four respiratory viruses in the intensive care unit: a multicenter retrospective study

Author

Grangier, Baptiste, Vacheron, Charles-Hervé, De Marignan, Donatien, Casalegno, Jean-Sebastien, Couray-Targe, Sandrine, Bestion, Audrey, Ader, Florence, Richard, Jean-Christophe, Frobert, Emilie, Argaud, Laurent, Rimmele, Thomas, Lukaszewicz, Anne-Claire, Aubrun, Frédéric, Dailler, Frédéric, Fellahi, Jean-Luc, Bohe, Julien, Piriou, Vincent, Allaouchiche, Bernard, Friggeri, Arnaud, and Wallet, Florent

Published
2024
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8. Multicenter Retrospective Study of Invasive Fusariosis in Intensive Care Units, France

Author

Demonchy, Jordane, Biard, Lucie, Clere-Jehl, Raphael, Wallet, Florent, Mokart, Djamel, Moreau, Anne-Sophie, Argaud, Laurent, Verlhac, Camille, Pene, Frederic, Lautrette, Alexandre, Bige, Naike, de Jong, Audrey, Canet, Emmanuel, Quenot, Jean-Pierre, Issa, Nahema, Zerbib, Yoann, Bouard, Ines, Picard, Muriel, and Zafrani, Lara

Subjects
Bacterial pneumonia -- Care and treatment, Mortality -- France, Hematopoietic stem cells -- Transplantation -- Health aspects, Pneumonia -- Care and treatment, Antifungal agents -- Health aspects, Hospital patients -- Care and treatment, Acute respiratory distress syndrome -- Care and treatment, Health
Abstract

Invasive fungal infections are common, and severe complications can occur in immunocompromised patients, especially in patients with hematologic malignancies who require intensive care unit (ICU) admission (2,2). Invasive fusariosis is [...]

Published
2024
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9. Severe infections requiring intensive care unit admission in patients receiving ibrutinib for hematological malignancies: a groupe de recherche respiratoire en réanimation onco-hématologique (GRRR-OH) study

Author

Baucher, Louise, Lemiale, Virginie, Joseph, Adrien, Wallet, Florent, Pineton de Chambrun, Marc, Ferré, Alexis, Lombardi, Romain, Platon, Laura, Contejean, Adrien, Fuseau, Charline, Calvet, Laure, Pène, Frédéric, Kouatchet, Achille, Mokart, Djamel, Azoulay, Elie, and Lafarge, Antoine

Published
2023
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12. Necrotizing soft tissue infections in critically ill neutropenic patients: a French multicentre retrospective cohort study

Author

Arrestier, Romain, Chaba, Anis, Mabrouki, Asma, Saccheri, Clément, Canet, Emmanuel, Pineton de Chambrun, Marc, Stoclin, Annabelle, Picard, Muriel, Wallet, Florent, Perier, François, Turpin, Matthieu, Argaud, Laurent, Decavèle, Maxens, Issa, Nahéma, Cadoz, Cyril, Klouche, Kada, Cohen, Johana, Mokart, Djamel, Grouille, Julien, Urbina, Tomas, Hua, Camille, Chosidow, Olivier, Mekontso-Dessap, Armand, Azoulay, Elie, and de Prost, Nicolas

Published
2023
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15. Relationship between COVID-19 and ICU-acquired colonization and infection related to multidrug-resistant bacteria: a prospective multicenter before-after study

Author

Kreitmann, Louis, Jermoumi, Sonia, Vasseur, Margot, Chabani, Myriam, Nourry, Emilie, Richard, Jean-Christophe, and Wallet, Florent

Subjects
Bacteria -- Health aspects -- Comparative analysis, Drug resistance in microorganisms -- Comparative analysis -- Health aspects, Severe acute respiratory syndrome -- Health aspects -- Comparative analysis, Coronaviruses -- Health aspects -- Comparative analysis, Health care industry
Abstract

Purpose Patients presenting the most severe form of coronavirus disease 2019 (COVID-19) pneumonia, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have a prolonged intensive care unit (ICU) stay and are exposed to broad-spectrum antibiotics, but the impact of COVID-19 on antimicrobial resistance is unknown. Methods Observational prospective before-after study in 7 ICUs in France. All consecutive patients with an ICU stay > 48 h and a confirmed SARS-CoV-2 infection were included prospectively and followed for 28 days. Patients underwent systematic screening for colonization with multidrug-resistant (MDR) bacteria upon admission and every week subsequently. COVID-19 patients were compared to a recent prospective cohort of control patients from the same ICUs. The primary objective was to investigate the association of COVID-19 with the cumulative incidence of a composite outcome including ICU-acquired colonization and/or infection related to MDR bacteria (ICU-MDR-col and ICU-MDR-inf, respectively). Results From February 27th, 2020 to June 2nd, 2021, 367 COVID-19 patients were included, and compared to 680 controls. After adjustment for prespecified baseline confounders, the cumulative incidence of ICU-MDR-col and/or ICU-MDR-inf was not significantly different between groups (adjusted sub-hazard ratio [sHR] 1.39, 95% confidence interval [CI] 0.91-2.09). When considering both outcomes separately, COVID-19 patients had a higher incidence of ICU-MDR-inf than controls (adjusted sHR 2.50, 95% CI 1.90-3.28), but the incidence of ICU-MDR-col was not significantly different between groups (adjusted sHR 1.27, 95% CI 0.85-1.88). Conclusion COVID-19 patients had an increased incidence of ICU-MDR-inf compared to controls, but the difference was not significant when considering a composite outcome including ICU-MDR-col and/or ICU-MDR-inf., Author(s): Louis Kreitmann [sup.1] [sup.2], Sonia Jermoumi [sup.1], Margot Vasseur [sup.1], Myriam Chabani [sup.2], Emilie Nourry [sup.2], Jean-Christophe Richard [sup.3], Florent Wallet [sup.4] [sup.5], Pierre Garçon [sup.6], Safaâ Kachmar [sup.6], [...]

Published
2023
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18. Relationship between immunosuppression and intensive care unit-acquired colonization and infection related to multidrug-resistant bacteria: a prospective multicenter cohort study

Author

Kreitmann, Louis, Vasseur, Margot, Jermoumi, Sonia, Perche, Juliette, Richard, Jean-Christophe, Wallet, Florent, and Chabani, Myriam

Subjects
Bacteria -- Analysis -- Health aspects -- Usage, Drug resistance in microorganisms -- Usage -- Analysis -- Health aspects, Imipenem -- Usage, Methicillin -- Usage, Hospital patients -- Analysis -- Usage -- Health aspects, Health care industry
Abstract

Purpose The impact of immunosuppression on intensive care unit (ICU)-acquired colonization and infection related to multidrug-resistant (MDR) bacteria (ICU-MDR-col and ICU-MDR-inf, respectively) is unknown. Methods We carried out an observational prospective cohort study in 8 ICUs in France (all with single-bed rooms and similar organizational characteristics). All consecutive patients with an ICU stay > 48 h were included, regardless of immune status, and followed for 28 days. Patients underwent systematic screening for colonization with MDR bacteria upon admission and every week subsequently. Immunosuppression was defined as active cancer or hematologic malignancy, neutropenia, solid-organ transplant, use of steroids or immunosuppressive drugs, human immunodeficiency virus infection and genetic. The primary endpoint was the incidence rate of a composite outcome including ICU-MDR-col and/or ICU-MDR-inf. Results 750 patients (65.9% males, median age 65 years) were included, among whom 264 (35.2%) were immunocompromised. Reasons for ICU admission, severity scores and exposure to invasive devices and antibiotics during ICU stay were comparable between groups. After adjustment for center and pre-specified baseline confounders, immunocompromised patients had a lower incidence rate of ICU-MDR-col and/or ICU-MDR-inf (adjusted incidence ratio 0.68, 95% CI 0.52-0.91). When considered separately, the difference was significant for ICU-MDR-col, but not for ICU-MDR-inf. The distribution of MDR bacteria was comparable between groups, with a majority of Enterobacteriacae resistant to third-generation cephalosporins (~ 74%). Conclusion Immunocompromised patients had a significantly lower incidence rate of a composite outcome including ICU-MDR-col and/or ICU-MDR-inf. This finding points to the role of contact precautions and isolation measures, and could have important implications on antibiotic stewardship in this population., Author(s): Louis Kreitmann [sup.1] [sup.2], Margot Vasseur [sup.1], Sonia Jermoumi [sup.1], Juliette Perche [sup.3], Jean-Christophe Richard [sup.4], Florent Wallet [sup.5] [sup.6], Myriam Chabani [sup.2], Emilie Nourry [sup.2], Pierre Garçon [sup.7], [...]

Published
2023
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20. Ultra-low tidal volume ventilation for COVID-19-related ARDS in France (VT4COVID): a multicentre, open-label, parallel-group, randomised trial

Author

BOURDIN, Gaël, VIVIER, Emmanuel, LARGE, Audrey, DONZE, Pierre, BOUZGARROU, Radhia, PERINEL RAGEY, Sophie, CHAUDIER, Caroline, DESEBBE, Olivier, FOLLIET, Laure, CHAUVELOT, Louis, CHABERT, Paul, DAVID, Guillaume, DANJOU, William, BETTINGER, Clotilde, BERNON, Pauline, DHELFT, Francois, COUR, Martin, SIMON, Marie, BAUDRY, Thomas, RIMMELE, Thomas, CARABALONA, Jean-François, GREGOIRE, Arnaud, FRIGGERI, Arnaud, DE-MARIGNAN, Donatien, ROCHE, Sylvain, Richard, Jean-Christophe, Terzi, Nicolas, Yonis, Hodane, Chorfa, Fatima, Wallet, Florent, Dupuis, Claire, Argaud, Laurent, Delannoy, Bertrand, Thiery, Guillaume, Pommier, Christian, Abraham, Paul, Muller, Michel, Sigaud, Florian, Rigault, Guillaume, Joffredo, Emilie, Mezidi, Mehdi, Souweine, Bertrand, Baboi, Loredana, Serrier, Hassan, Rabilloud, Muriel, and Bitker, Laurent

Published
2023
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21. HLA-DR expression on monocytes and outcome of anti-CD19 CAR T-cell therapy for large B-cell lymphoma

Author

Bourbon, Estelle, Sesques, Pierre, Gossez, Morgane, Tordo, Jérémie, Ferrant, Emmanuelle, Safar, Violaine, Wallet, Florent, Aussedat, Guillaume, Maarek, Alizée, Bouafia, Fadhela, Karlin, Lionel, Ghergus, Dana, Golfier, Camille, Lequeu, Hélène, Lazareth, Anne, Schwiertz, Vérane, Viel, Sébastien, Idlhaj, Maryam, Ghesquières, Hervé, Monneret, Guillaume, Bachy, Emmanuel, and Venet, Fabienne

Published
2023
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23. Impact of prolonged requirement for insulin on 90-day mortality in critically ill patients without previous diabetic treatments: a post hoc analysis of the CONTROLING randomized control trial

Author

Thouy, François, Bohé, Julien, Souweine, Bertrand, Abidi, Hassane, Quenot, Jean-Pierre, Thiollière, Fabrice, Dellamonica, Jean, Preiser, Jean-Charles, Timsit, Jean-François, Brunot, Vincent, Klich, Amna, Sedillot, Nicholas, Tchenio, Xavier, Roudaut, Jean-Baptiste, Mottard, Nicolas, Hyvernat, Hervé, Wallet, Florent, Danin, Pierre-Eric, Badie, Julio, Jospe, Richard, Morel, Jérôme, Mofredj, Ali, Fatah, Abdelhamid, Drai, Jocelyne, Mialon, Anne, Ait Hssain, Ali, Lautrette, Alexandre, Fontaine, Eric, Vacheron, Charles-Hervé, Maucort-Boulch, Delphine, Klouche, Kada, and Dupuis, Claire

Published
2022
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24. Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses

Author

Pan, Hongchao, Peto, Richard, Henao Restrepo, Ana Maria, Preziosi, Marie-Pierre, Sathiyamoorthy, Vasee, Karim, Quarraisha Abdool, Alejandria, Marissa, Hernàndez García, César, Kieny, Marie-Paule, Malekzadeh, Reza, Murthy, Srinivas, Reddy, K. Srinath, Periago, Mirta Roses, Hanna, Pierre Abi, Abutidze, Akaki, Ader, Florence, Al-Bader, Abdullah, Alhasawi, Almonther, Allum, Emma, Al Mawali, Adhra, Alotaibi, Athari, Alvarez- Moreno, Carlos, Appadoo, Sheila, Arts, Derk, Asiri, Abdullah, Aukrust, Pål, Barratt-Due, Andreas, Genetu Bayih, Abebe, Beaumont, Helena, Bellani, Samir, Benassi, Virginia, Bhargava, Balram, Branca, Mattia, Cappel-Porter, Heike, Cerrato, Nery, Cheick Haidara, Fadima, Chow, Ting Soo, Como, Nadia, Eustace, Joe, Gabunia, Tamar, García, Patricia, Godbole, Sheela, Gotuzzo, Eduardo, Griskevicius, Laimonas, Hamra, Rasha, Hassan, Mariam, Hassany, Mohamed, Hutton, David, Irmansyah, Irmansyah, Jancoriene, Ligita, Khamis, Faryal, Kirwan, Jana, Kumar, Suresh, Lennon, Peter, Lopardo, Gustavo, Lydon, Patrick, Magrini, Nicola, Manevska, Suzana, Manuel, Oriol, McGinty, Sybil, Medina, Marco, Mesa Rubio, Maria Lucia, Miranda Montoya, Maria Consuelo, Nel, Jeremy, Nunes, Estevao, Perola, Markus, Portoles, Antonio, Rasmin, Menaldi, Raza, Aun, Rees, Helen, Reges, Paula, Rogers, Chris, Salami, Kolawole, Salvadori, Marina, Sauermann, Mamatha, Sinani, Narvina, Sow, Samba, Sterne, Jonathan AC, Stevanovikj, Milena, Tacconelli, Evelina, Tavares Maltez, Fernando Manuel, Teferi, Mekonnen, Tikkinen, Kari, Trelle, Sven, Tsertsvadze, Tengiz, Zaid, Hala, Røttingen, John-Arne, Swaminathan, Soumya, Ryan, Michael, Gjermeni, Nevila, Meta, Esmeralda, Aguila, Damian, Alonso, Ignacio, Altamirano, Marcos, Alvarez, María, Alzola, Rodrigo, Arce, Veronica, Arribillaga, Patricia, Avila, Rafael, Balbuena, Juan, Barcelona, Laura, Barletta, José, Benedetti, María, Berdiñas, Verónica, Burgui, Julieta, Caimi, Sabrina, Carrillo, Juan, Carrizo, Juan, Castelli, Juan, Cazaux, Alexis, Cervellino, Flavia, Chalco, Angelo, Chediack, Viviana, Cunto, Eleonora, D'Amico, Nicolàs, de Vedia, Lautaro, Delgado, Carolina, Di Pilla, Debora, Díaz, Miguel, Díaz Aguiar, Pablo, Domínguez, Cecilia, Ellero, Leonor, Farina, Javier, Fernàndez, José, Ferreyra, Roxana, Filippi, María, Fogar, Carolina, Frare, Pablo, Giudiche, Celeste, Golikow, Mariana, Gomez, Maria Georgina, Hermida, Laura, Hurtado, Mariano, Jacobo, Mariela, Jaume, Martin, Laplume, Diego, Lescano, María, Lista, Nicolàs, Loiacono, Flavia, López, Ana Belen, Losso, Marcelo, Luna, Cecilia, Lupo, Sergio, Marianelli, Leonardo, Martin, Anabella, Masciottra, Florencia, Mykietiuk, Analía, Orellano, Lorena, Pachioli, Valeria, Padilla, María José, Pallavicini, Cecilia, Patroso, Jazmin, Perez Blanco, Luz, Presas, Jose Louis, Provenzano, Matias, Lavera, Lorena, Reichert, Viviana, Riveros, Florencia, Rodríguez, Alejandra, Rolon, María José, Salvay, Carolina, Simonetta, María, Sisto, Alicia, Themines, Sandra, Tito, Fernando, Toibaro, Javier, Torales, Graciela, Verón, Luciano, Vizzotti, Carla, Egle, Alexander, Greil, Richard, Joannidis, Michael, Altdorfer, Antoine, Belkhir, Leila, Fraipont, Vincent, Hites, Maya, Arruda, Erico, Breda, Giovanni, Colussi, Arthur, Corradi, Miran, Croda, Julio, Duani, Helena, João, Esaú, Machado, Elizabeth, Mello, Fernanda, Miranda Filho, Demócrito, Monteiro, Poliana, Nunes, Ceuci, Pereira Junior, Luiz Carlos, Pinto, Gustavo, Raboni, Sonia, Ramos, Marcelo, Ruffing, Leonardo, Santos, Valdilea, Souza, Tamara, Medeiros, Melissa, Schwarzbold, Alexandre, Ali, Karim, Azher, Tanweer, Bellemare, David, Binnie, Alexandra, Borgia, Sergio, Cavayas, Yiorgos Alexandros, Chagnon, Nicholas, Cheng, Matthew, Cloutier, Eve, Conly, John, Costiniuk, Cecilia, Daneman, Nick, Douglas, James, Downey, Catarina, Duan, Erick, Durand, Medeline, English, Shane, Farjou, George, Fera, Evadiki, Fontela, Patricia, Fowler, Rob, Fralick, Mike, Gamble, David Gregory, Geagea, Anna, Grant, Jennifer, Harrison, Luke, Havey, Thomas, Hoang, Holly, Kelly, Lauren, Keynan, Yoav, Khwaja, Kosar, Klein, Marina, Kolan, Christophe, Kronfli, Nadine, Lamontagne, Francois, Lee, Nelson, Lee, Todd, Lim, Rachel, Lostun, Alexandra, MacIntyre, Erika, Malhamé, Isabelle, Martin-Carrier, Francois, McGuinty, Marlee, Munan, Matthew, O'Neil, Conar, Ovakim, Daniel, Papenburg, Jesse, Parhar, Ken, Parvathy, SeemaNair, Perez-Patrigeon, Santiago, Rishu, Asgar, Rushton, Moira, Scherr, Kim, Schwartz, Kevin, Semret, Makeda, Silverman, Micahel, Singh, Ameeta, Sligl, Wendy, Smith, Stephanie, Somayaji, Ranjani, Tan, Darrell, Tran, Tuong-Vi, Tremblay, Alain, Tsang, Jennifer, Turgeon, Alexis, Vakil, Erik, Weatherald, Jason, Yansouni, Cedric, Zarychanski, Ryan, Aristizabal, Claudia, Bravo, Juan, Caicedo, Monica, Chacón, Julio, Garzón, Diego, Guevara, Fredy, Lozano-Gonzàlez, Silvia, Macareno, Hugo, Montañez-Ayala, Anita, Oñate, Jose, Rojas-Gambasica, Jose, Rosso, Fernando, Saavedra, Carlos, Valderrama, Sandra, Vàquiro-Herrera, Eliana, Varón-Vega, Fabio, Zuluaga, Ivan, Abdel Baki, Amin, Abdelbary, Akram, Abdel-Razek, Wael, Amin, Wagdi, Asem, Noha, Elassal, Gehan, Elshesheny, Marwa, Fathy, Mohamed, Fathy, Naglaa, Fayed, Notaila, Hammam, Ahmed, Hassany, Sahar, Ibrahim, Hamdy, Kamal, Ehab, Masoud, Hossam, Mohamed, Maryam, Mohamed Gouda, Abdullah, Moustafa, Ehab, Okasha, Shaimaa, Rafik, Ahmed, Said, Ahmed, Sedky, Asmaa, Solyman Kabil, Mohamed, Tarek, Sara, Tharwat, Ahmed, Zaky, Samy, Abegaz, Emawayish Tesema, Bekele, Zelalem Mekonnen, Asfaw, Filmona Mekuria, Tegegne, Netsanet Aragaw, Teklemariam, Miheret Fikre, Nigusse, Frehiwot Tamiru, Achalu, Daniel Legesse, Weldegergs, Shewit Tesfagabr, Huluka, Dawit Kebede, Tereda, Addisu Birhanu, Ala-Kokko, Tero, Delany, Jutta, Ekroos, Heikki, Hankkio, Riina, Haukipää, Mia, Hetemäki, Iivo, Holma, Pia, Holmberg, Ville, Horstia, Saana, Jalkanen, Ville, Jämsänen, Toni, Järventie, Juuso, Järvinen, Petrus, Kalliala, Ilkka, Kauma, Heikki, Kilpeläinen, Tuomas, Kreivi, Hanna-Riikka, Kuitunen, Ilari, Lamminmäki, Satu, Mäkinen, Laura, Mäntylä, Jarkko, Mattila, Tiina, Myllärniemi, Marjukka, Niskanen, Joni, Nykänen, Taina, Nyqvist, Miro, Paajanen, Juuso, Partanen, Terhi, Patovirta, Riitta-Liisa, Paukkeri, Erja-Leena, Puusti, Emmi, Renner, Andreas, Reponen, Emma, Risku, Sari, Rosberg, Tuomas, Rutanen, Jarno, Säilä, Petrus, Salonen, Päivi, Sinisalo, Marjatta, Sivenius, Katariina, Tuominen, Susanna, Aboab, Jerone, Alfaiate, Toni, Andrejak, Claire, Andreu, Pascal, Belhadi, Drifa, Benezit, Francois, Botelho-Nevers, Elisabeth, Bouadma, Lila, Bougon, David, Bouiller, Kevin, Bounes, Fanny, Boyer, Alexandre, Bruel, Cédric, Buffet, Alexandre, Burdet, Charles, Cazanave, Charles, Chabertier, Cyrille, Clere-Jehl, Rapahel, Costagliola, Dominique, Courjon, Johan-Victor, Crockett, Flora, Danion, Francois, Dechanet, Aline, Dellamonica, Jean, Delmas, Christelle, Diallo, Alpha, Djossou, Felix, Dubost, Clement, Dupont, Axelle, Epaulard, Olivier, Faure, Emmmanuel, Faure, Karine, Fayol, Antoine, Figueiredo, Samy, Fougerou, Claire, Gaborit, Benjamin, Gaci, Rostane, Gagneux-Brunon, Amandine, Gallien, Sebastien, Garot, D, Goehringer, Francois, Gruson, Didier, Hinschberger, Olivier, Hulot, Jean-Sebastien, Jaureguiberry, Stephane, Jean-Michel, Vanessa, Kerneis, Solen, Kimmoun, Antoine, Klouche, Kada, Lachatre, Marie, Lacombe, Karine, Laine, Fabrice, Lanoix, Jean Philippe, Laribi, Samira, Launay, Odile, Laviolle, Bruno, Le Moing, Vincent, Le Pavec, Jerome, Lebeaux, David, Leroy, Sylvie, Lescure, Xavier, Livrozet, Marine, Makinson, Alain, Malvy, Denis, Marquette, Charles-Hugo, Martin-Blondel, Guillaume, Mayaux, Julien, Mekontso Dessap, Armand, Mentre, France, Mercier, Noemie, Meziani, Ferhat, Molina, Jean Michel, Mootien, Yoganaden, Mourvillier, Bruno, Navellou, Jean Christoph, Noret, M, Peiffer- Smadja, Nathan, Peytavin, Gilles, Pialoux, Gilles, Pilmis, Benoît, Piroth, Lionel, Poindron, Vincent, Poissy, Julien, Pourcher, Valerie, Quenot, Jean Pierre, Raffi, Francois, Reignier, Jean, Richard, Jean Christoph, Robert, Céline, Saillard, Juliette, Sayre, Naomi, Senneville, Eric, Stefan, Francois, Tellier, Marie Capucine, Terzi, Nicolas, Textoris, Julien, Thiery, Guillame, Timsit, Jean Francois, Tolsma, Violaine, Tubiana, Sarah, Wallet, Florent, Yazdanpanah, Yazdan, Zerbib, Yoann, Aguilar, Carlos, Erazo, Laura, Fiallos, Angel, Figueroa, Rosbinda, Flores, Juan Jose, Melendez, Lesddyy, Moncada, Wendy, Abraham, Ooriapadickal Cherian, Acharya, Chetankumar, Aedula, Vinaya Sekhar, Aggarwal, Richa, Agrawal, Nishant, Agrawal, Umang, Agrawal, Abhishekh, Ahmad, Mohammad, Atal, Shubham, Babu, Avinash, Baidya, Dalim Kumar, Balachandran, Amith, Bangar, Rakhee, Bhadade, Rakesh, Bhandari, Sudhir, Bhapal, Meghavi, Bhardwaj, Pankaj, Bhati, Gaurav, Bhatia, Pradeep, Bhatt, Krishnakant, Bingi, Thrilok Chander, Borse, Rohidas, Buch, Vyom, Chand, Dipti, Chandwani, Ashish, Charan, Jaykaran, Chaudhari, Mayur, Chaudhari, Kirti, Chaudhary, Vipul, Chauhan, Nishant, Chikara, Gaurav, Daswani, Bharti, de Souza, Rosemarie, Desai, Chetna, Divakar, Balusamy, Divhare, Sujeet, Dorairajan, Suresh Kumar, Dutt, Naveen, Ethirajan, Therani Rajan, Gamit, Amit, Gamit, Sweta, Garg, Mahendra, Goenka, Ajay, Goenka, Aniket, Guleria, Randeep, Gupta, Paras, Gupta, Nivedita, Gupta, Madhur, Harde, Minal, Ingle, Vaibhav, Iyer, Shivkumar, Jamalapuram, Vaishnavi, Jayanthi, Rangarajan, Joshi, Rajnish, Kadam, Abhijeet, Kalakuntla, Hemanth, Kalikar, Mrunalini, Kalme, Sayali, Kamble, Suchit, Kant, Ravi, Kantharia, Bansari, Kashikar, Arundhati, Kavishvar, Abhay, Kayina, Choro Athipro, Kerkar, Pranali, Khadanga, Sagar, Khandare, Sagar, Kokate, Pranjali, Komathi, Jayavelu, Krishnan, Vijay, Krishnan, Jayasree, Krishnan, Sumitra, Kulur Mukhyaprana, Sudha, Kumarasamy, N, Mahavar, Sunil, Maitra, Souvik, Majumdar, Falguni, Malhotra, Supriya, Mamulwar, Megha, Malini, Padma, Marwah, Vikas, Maurya, Akhilesh, Mehta, Kedar, Mesipogu, Rajarao, Misra, Shobha, Mitra, Sajal, Mittal, Ankit, Mohan, Bharathi, Momin, Mohmmedirfan, Nag, Vijaya, Nagarajan, Ramakrishnan, Nagmani, Kammili, Narlawar, Uday, Natarajan, Gopalakrishnan, Nischal, Neeraj, Ogale, Dhananjay, Palat, Paltial, Panda, Prasan, Panda, Samiran, Pandya, Amee, Parate, Rohit, Paritekar, Arunita, Patel, Parvati, Patel, Chetna, Patel, Sunaina, Patel, Vitan, Patel, Deep, Patel, Harshad, Patil, Girish, Peter, Deepu, Prasad, Durga, Purohit, Vimlesh, Rabindrarajan, Ebenezer, Ranganathan, Lakshmiarasimhan, Rao, Tushara, Rao, Chakradhara, Rathod, Chirag, Raval, Devang, Ray, Avik, Reddy, Kamini, Rege, Sujata, Revathi, Ayyasamy, Roy, Dhara, Saigal, Saurabh, Sane, Suvarna, Sangale, Shashi, Seetharaman, Krishnamoorthy, Selvamuthu, Poongulali, Seshaiah, Kurada Venkata, Shadrach, Benhur, Shah, Jignesh, Shah, Sonal, Sharma, Swati, Sharma, Raman, Sharma, Shrikant, Singh, Krishna, Singh, Anil, Singh, Arjeet, Singhai, Abhishek, Soneja, Manish, Soni, Kapil Dev, Subhan, Thasneem banu, Subramaniam, Sudharshini, Sudarsanam, Thambu David, Sudarsi, Ravindra Kumar, Suleman, Dawood, Suthar, Nilay, Talati, Shriraj, Tambe, Murlidhar, Tejomurtula, Tilak, Tirupakuzhi Vijayaraghavan, Bharatkumar, Trikha, Anjan, Trivedi, Aarti, Udwadia, Zarir, Upadhyay, Kamlesh, Vasava, Ashwin, Vasudevan, Damodaran, Velayudham, Rajendran, Venkatasubramanian, Ramasubramanian, Verma, Mamta, Waghmare, Rakesh, Waikar, Anushka, Wig, Naveet, Afrilia, Annisa Rizky, Amin, Muhammad, Arlinda, Dona, Avrina, Rossa, Bang, Lois, Djaharuddin, Irawaty, Djojo, Aryan, Driyah, Sri Laning, Erastuti, Mila, Fajarwati, Tetra, Harsini, Harsini, Hartantri, Yovita, Herman, Deddy, Isbaniah, Fathiyah, Karyana, Muhammad, Kusuma, Indra, Mahmudji, Harli Amir, Medison, Irvan, Nugroho, Agung, Nurhayati, Nurhayati, Opitasari, Cicih, Pitoyo, Ceva Wicaksono, Pradana, Antonius Arditya, Raharjo, Sofyan Budi, Rahmaini, Ade, Risniati, Yenni, Riyanto, Bambang Sigit, Sajinadiyasa, I Gede Ketut, Sari, Flora Eka, Sitompul, Pompini Agustina, Soedarsono, Soedarsono, Somia, I Ketut Agus, Sugiri, Yani Jane, Sugiyono, Retna Indah, Susanto, Nugroho Harry, Syarif, Armaji Kamaludi, Yulianto, Aris, Afsharian, Mandana, Akhavi Mirab, Atefehsadat, Amini, Fatemeh, Amini, Mahnaz, Ansarin, Khalil, Baba Mahmoodi, Farhang, Baghaei, Parvaneh, Barazandeh, Fateme, Bayani, Masomeh, Dastan, Farzaneh, Ebrahimpour, Soheil, Eghtesad, Sareh, Fallahi, Mohammad Javad, Fallahpoor Golmaee, Fatemeh, Foroghi Ghomi, Seyed Yaser, Ghadir, Mohammad Reza, Gheitani, Mina, Ghiasvand, Fereshteh, Hafizi Lotfabadi, Saied, Hakamifard, Atousa, Hashemi Madani, Shima Sadat, Hormati, Ahmad, Hosseini, Hamed, Janbakhsh, Alireza, Javanian, Mostafa, Joukar, Farahnaz, Kamali, Alireza, Karampour, Amin, Khajavirad, Nasim, Khodabakhshi, Behnaz, Khodadadi, Javad, Khodashahi, Rozita, Kiani Majd, Somaieh, Mahfoozi, Lida, Mahmoodiyeh, Behnam, Mansour-Ghanaei, Fariborz, Mansouri, Feizollah, Mesgarpour, Bita, Mesri, Mehdi, Mikaeili, Haleh, Miladi, Ronak, Moghadami, Mohsen, Mohamadi, Payam, Mohraz, Minoo, Mohseni Afshar, Zeinab, Moogahi, Sasan, Mousavi Anari, Seyed Alireza, Mozaffar, Seyyed Hassan, Mozdourian, Mahnaz, Najafipour, Reza, Najari, Hamidreza, Nazemiyeh, Masoud, Norouzi, Alireza, Pourkazemi, Aydin, Poustchi, Hossein, Saberhosseini, Seyedeh Naeimeh, Saberi, Marzieh, Saber-Moghaddam, Niloufar, Sadeghi, Anahita, Sadeghi Haddad Zavareh, Mahmoud, Sahraian, Mohammad Ali, Salahi, Mehrdad, Salehi, Mohammad Reza, Sarmadian, Hossein, Sayad, Babak, Shirani, Kiana, Shirvani, Maria, Shojaei, Daryanaz, Shokri, Mehran, Siami, Zeinab, Sima, Ali Reza, Soleimani, Alireza, Soltanmohammad, Saedeh, Tabarsi, Payam, Taghizadieh, Ali, Tavassoli, Samaneh, Varnasseri, Mehran, Vaziri, Siavash, Yadyad, Mohammad Jaafar, Yaghoubi, Shoeleh, Yazdanpanah, Yalda, Yousefi, Farid, Zamanian, Mohammad Hossein, Zand, Farid, Zare Hoseinzade, Elham, Bergin, Colm, Cotter, Aoife, de Barra, Eoghan, Jackson, Arthur, Laffey, John, McCarthy, Cormac, Muldoon, Eavan, Sadlier, Corinna, Maguire, Teresa, Angheben, Andrea, Bai, Francesca, Bandera, Alessandra, Barchiesi, Francesco, Bassetti, Matteo, Bisi, Luca, Bonfanti, Paolo, Calò, Federica, Campoli, Caterina, Canovari, Benedetta, Capetti, Amedeo, Castelli, Francesco, Cauda, Roberto, Cingolani, Antonella, Cocco, Nicolò, Coppola, Nicola, Corcione, Silvia, Cremonini, Eleonora, d'Arminio Monforte, Antonella, de Gaetano Donati, Katleen, De Nardo, Pasquale, De Rosa, Francesco Giuseppe, Degioanni, Maria, Della Siega, Paola, Di Bella, Stefano, Drera, Bruno, Focà, Emanuele, Fornabaio, Chiara, Galli, Massimo, Giacomazzi, Donatella, Gori, Andrea, Gustinetti, Giulia, Iannuzzi, Francesca, Kertusha, Blerta, Lamonica, Silvia, Lichtner, Miriam, Lupia, Tommaso, Luzzati, Roberto, Macera, Margherita, Menatti, Elisabetta, Merelli, Maria, Merlini, Esther, Monari, Caterina, Pan, Angelo, Pecori, Davide, Pezzani, Diletta, Riccardi, Niccolò, Rodari, Paola, Roldan, Eugenia, Rovere, Pierangelo, Rusconi, Stefano, Scabini, Silvia, Tascini, Carlo, Viale, Pierluigi, Vincenzi, Marcello, Zuccalà, Paola, Zucchi, Patrizia, Al-Roomi, Moudhi, Al-Sabah, Salman, Schrapp, Kelly, Hassoun, Mahmoud, Matar, Madonna, Dbouni, Oussaima, Yared, Nadine, Saliba, Michele, Farra, Anna, Riachi, Moussa, Zablockiene, Birute, Reuter, Jean, Staub, Therese, Ab Wahab, Suhaila, Chew, Chun Keat, Chua, Hock Hin, Goh, Pik Pin, Lee, Heng Gee, Leong, Chee Loon, Low, Lee Lee, Mak, Wen Yao, Mohamed Gani, Yasmin, Muhamad, Dzawani, Zaidan, Nor Zaila, Ducker, Camilla, Demiri, Ilir, Aballi, Saad, Berg, Åse, Blomberg, Bjørn, Dalgard, Olav, Dyrhol-Riise, Anne Ma, Eiken, Ragnhild, Ernst, Gernot, Hannula, Ranula, Haugli, Metter, Heggelund, Lars, Hoel, Hedda, Hoff, Dag Arne Lihaug, Holten, Aleksander Rygh, Johannessen, Asgeir, Kåsine, Trine, Kildal, Anders Benjamin, Kittang, Bård Reikvam, Nezvalova-Henriksen, Katerina, Olsen, Inge Christoffer, Olsen, Roy Bjørkolt, Skei, Nina Vibeche, Skudal, Hilde, Tholin, Birgitte, Thoresen, Lars, Trøseid, Marius, Tveita, Anders, Vinge, Leif, Ystrøm, Carl Magnus, Al Jahdhami, Issa, AlNaamani, Khalid, Al Balushi, Zakariya, Pandak, Nenad, Abbas, Salma, Akhtar, Nasim, Azam, Sumeyya, Begum, Dilshad, Hassan, Sadia, Herekar, Fivzia, Khan, Shahzaib, Khan, Ejaz Ahmed, Mahmood, Syed Faisal, Nasir, Nosheen, Rahim, Anum, Sarfaraz, Samreen, Shaikh, Qurat-ul-Ain, Sultan, Faisal, Walayat, Usman, Agurto-Lescano, Erika Cecilia, Alcantara-Díaz, Andrés Martín, Alva-Correa, Ana María, Alvarado-Moreno, José Gustavo, Ángeles-Padilla, Bethsabé, Arbañil-Huamàn, Hugo César, Ávila-Reyes, Pool Christopher, Azañero-Haro, Johan Alexander, Barreto-Rocchetti, Luis Guillermo, Benitez-Peche, Jorge Marko A., Bernal-Màlaga, Karla Hortencia, Cabrera-Portillo, Liliana Norma, Carazas-Chavarry, Reynaldo Javier, Càrcamo, Paloma Mariana, Casimiro-Porras, Indira Catalina, Castillo-Espinoza, Jhuliana, Chacaltana-Huarcaya, Jesús Norberto, Cornejo-Valdivia, Carla Raquel, Cruz-Chereque, Augusto, Del-Aguila-Torres, Keith Cayetano Marcelino, Díaz-Chipana, Erika, Flores-Valdez, Neil, Franco-Vàsquez, Rosanna Andrea, Gallegos-López, Roxana Consuelo, Gastiaburú-Rodriguez, Dauma Yesenia, Gianella-Malca, Gonzalo Ernesto, Gomero-Lopez, Andrés Alonso, Hercilla-Vàsquez, Luis Enrique, Hueda-Zavaleta, Miguel Ángel, Ibarcena-Llerena, Claudia Vanessa, Iberico-Barrera, Carlos Alberto, Inquilla-Castillo, Miguel Angel, Juàrez-Eyzaguirre, Jesus Alberto, Laca-Barrera, Manuel, León-Jiménez, Franco, Luna-Wilson, Carla Vanessa, Màlaga, German, Marin, Ricardo, Mejía-Cordero, Fernando, Mendoza-Laredo, Juan Arturo, Meregildo-Rodríguez, Edinson Dante, Miranda-Manrique, Gonzalo Francisco, Olivera-Chaupis, Marco, Ortega-Monasterios, Fatima Josefina, Otazú-Ybàñez, Jimmy Pedro, Paredes-Moreno, María Angélica, Peña-Mayorga, Claudia Ximena, Peña-Vàsquez, Olivia del Carmen, Peña-Villalobos, Alejandro, Ponce, Oscar J, Ponte-Fernandez, Katherin Estefania, Pro, Jose, Quispe-Nolazco, César Miguel, Ramos-Samanez, Manuel Efrain, Rojas-Murrugarra, Kory Mirtha, Samanez-Pérez, Jorge Mauro, Sànchez-Carrillo, Halbert Chrostian, Sànchez-Garavito, Epifanio, Sànchez-Sevillano, Ricardo Manuel, Sandoval-Manrique, Hernan, Santos-Revilla, Gabriela, Silva-Ramos, Julio Antonio, Solano-Ico, Manuel Alberto, Soto, Alonso, Sotomayor-Woolcott, Giannilu Michelle, Tapia-Orihuela, Ruben Kevin Arnold, Terrazas-Obregón, Carmen Sara, Terrones-Levano, Victor Francisco, Ticona-Huaroto, Cesar Eduardo, Torres-Ninapayta, Walter, Torres-Ruiz, Oscar Martin, Ugarte-Mercado, Dario, Vargas-Anahua, Orlando José, Vàsquez-Becerra, Ruben Dario, Vàsquez-Cerro, José Gabriel, Villegas-Chiroque, Miguel, Williams, Anna Larson, Yauri-Lazo, Randi Mauricio, Abad, Cybele Lara, Andales-Bacolcol, Silverose Ann, Arcegono, Marlon, Arches, Jamie, Astudillo, Mary Grace, Aventura, Emily, Awing, Arlyn, Bala, Mishelle Vonnabie, Bello, Jia An, Blanco, Peter, Benedicto, Jubert, Buno, Susana, Cabrera, Justine, Cajulao, Thea Pamela, Caoili, Janice, Casiple-Amsua, Lina, Catambing, Victor, Chin, Inofel, Chua, Ma. Bernadette, Chua, Mitzi Marie, Climacosa, Fresthel Monica, David-Wang, Aileen, De los Reyes, Virginia, Europa, Gilly May, Fernandez, Lenora, Francisco, Jorge, Garcia, Gerard, Garcia, Jemelyn, Gler, Maria Tarcela, Isidro, Marie Grace Dawn, Javier, Rozelle Jade, Kwek, Marion, Lansang, Mary Ann, Lee, Aileen, Li, Kingbherly, Llanes, Mark Ramon Victor, Llorin, Ryan, Macadato, Omar Khayyam, Malundo, Anna Flor, Mercado, Maria Elizabeth, Mujeres, Mercedes, Nepomuceno, Marisse, Ngo-Sanchez, Katha, Orden, Mary Claire, Pablo-Villamor, Maria Philina, Paez, Ruel Dionisio, Palmes, Patricio, Panaligan, Marion, Quinivista-Yoon, Jenny Mae, Ramos, Mary Shiela Ariola, Ramos -Penalosa, Christine, Reyes, Sheila Marie, Roa, Kathryn, Roman, Arthur Dessi, Rosario, Minette Claire, Roxas, Evalyn, Santos, Lourdes Ella Gonzales, Soldevilla, Helmar, Solante, Rontgene, Suaco, Jane, Tagarda, Daisy, Tang, Issa Rufina, Te, Bob, Teo, Dennis, Tibayan, Christopher John, Villalobos, Ralph Elvi, Ymbong, Duane Richard, Zabat, Gelza Mae, Batkova, Stepanka, Cardoso, Orlando, Garrote, Ana-Raquel, Lino, Sara, Manata, Maria-José, Pinheiro, Helder, Póvoas, Diana, Ramirez, Freddy, Seixas, Diana, Naji, Assem, Al Gethamy, M Al, AL-Mulaify, Mohammed Sami, Al Maghraby, Reem, Alrajhi, A, Al Sharidi, Aynaa, Alotaibi, Naif, AlShaharani, F, Barry, Mazin, Ghonem, Leen, Khalel, Anas, Kharaba, Ayman Mohammed, Alabdan, Lulwah, AlAbdullah, Mohammed Sharaf, Al Shabib, Abdullah, Bengu, Simangele, Bennet, Jacklyn, Dubula, Thozama, Howell, Pauline, Janse van Vuuren, Cloete, Kalla, Ismail, Lifson, Aimee, Maasdorp, Shaun, Magua, Nombulelo, Maluleke, Vongani, Mbhele, Nokuphiwa, Mdladla, Nathi, Mendelson, Mark, Menezes, Colin, Mwelase, Thando, Nchabeleng, Maphoshane, Palanee-Phillips, Thesla, Parker, Victoria, Rassool, Mohammed, Reeder, Paul, Sossen, Bianca, Steyn, Dewald, Tsitsi, Merika, van Blydenstein, Sarah Alex, Venter, Michelle, Van Vuuren, Janse, Venturas, Jacquie, Abad Pérez, Daniel, Abenza, Maria José, Alarcón-Payer, Carolina, Armero Garrigos, Eva, Arribas, Jose Ramon, Ascaso, Ana, Berenguer, Juan, Cabello-Clotet, Noemí, Chamorro Tojeiro, Sandra, Cuenca-Acevedo, Rafael, de la Calle, Fernando, Del Toro, Maria Dolores, Díaz Pollàn, Beatriz, Diez, Cristina, Esquillor-Rodrigo, María José, Estrada, Vicente, Fanciulli, Chiara, Fanjul, Francisco, Fernàndez de Orueta, Lucía, Ferre, Adrian, Ferreira Pasos, Eva Maria, Gainzarain-Arana, Juan-Carlos, Garcia, Felipe, García Deltoro, Miguel, Goikoetxea Agirre, Ane Josune, Gómez Barquero, Julia, Gomez-Huelgas, Ricardo, Gonzàlez Moraleja, Julio, Guijarro, Carlos, Gutierrez, Felix, Guzmàn, Jesús, Ibarguren, Maialen, Iribarren, Jose Antonio, Jerusalem, Koen, Juan Arribas, Arturo, Lalueza, A, Leone, Antonio, Lopez Azkarreta, Iñigo, Lozano-Martin, Daniel, Lucendo, Alfredo J, Luengo López, Mariella, Martín Oterino, JA, Masa, JF, Merino, Esperanza, Monge-Maillo, Begoña, Moran-Rodríguez, Miguel-Angel, Muñez Rubio, Elena, Muñoz Sanchez, Josefa, Nuñez Orantos, Maria Jose, Nuño, Enrique, Ortiz-De-Zarate-Ibarra, Zuriñe, Pagàn-Muñoz, Bàrbara, Paño-Pardo, José Ramón, Peñaranda, Maria, Pérez Chica, Gerardo, Pérez Fernàndez, AM, Pérez-López, Carmen, Polo San Ricardo, Victor, Portu-Zapirain, Joseba, Puchades, Francesco, Rivas Paterna, Ana Belen, Rodríguez Vidigal, Francisco F, Rodríguez-Baño, Jesus, Ruiz-Seco, Pilar, Ryan, Pablo, Saez-De-Adana, Ester, Salas, Rosario, Salavert Lletí, Miguel, Sandoval, Raquel, Toyas-Miazza, Carla, Valencia, Jorge, Vargas, Emilio, Velasco, Maria, Von Wichmann, Miguel Angel, Bosshard, Andreas, Calmy, Alexandra, Castro, Tiago, Cavassini, Matthias, Clerc, Olivier, Conen, Anna, Desbaillets, Nicolas, Desgranges, Florian, Duss, Francois, Emonet, Stephane, Erard, Veronique, Eyer, Myriam, Fayet-Mello, Aurélie, Flammer, Yvonne, Friedl, Andrée, Fulchini, Rosamaria, Furrer, Hansjakob, Garin, Nicolas, Gastberger, Salome, Greiner, Michael, Haefliger, David, Haubitz, Sebastian, Hoffmann, Matthias, Isenring, Egon, Jakopp, Barbara, Lampert, Markus, Marinosci, Annalisa, Martin, Yvonne, Petignat, Pierre-Auguste, Piso, Rein Jan, Prendki, Virginie, Rutishauser, Jonas, Schaefer, Elisabeth, Schmiedel, Yvonne, Schwery, Stefan, Stavropoulou, Elisavet, Stoeckle, Marcel, Suttels, Veronique, Thurnher, Maria Christine, van den Bogaart, Lorena, West, Emily, Wiegand, Jan, and Wiggli, Benedikt

Published
2022
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25. Outcomes in Critically Ill Allogeneic Hematopoietic Stem-Cell Transplantation Recipients.

Author

Lafarge, Antoine, Dupont, Thibault, Canet, Emmanuel, Moreau, Anne-Sophie, Picard, Muriel, Mokart, Djamel, Platon, Laura, Mayaux, Julien, Wallet, Florent, Issa, Nahema, Raphalen, Jean-Herlé, Pène, Frédéric, Renault, Anne, Peffault de la Tour, Régis, Récher, Christian, Chevallier, Patrice, Zafrani, Lara, Darmon, Michael, Bigé, Naike, and Azoulay, Elie

Subjects
STEM cell transplantation, MORTALITY risk factors, ADULT respiratory distress syndrome, RENAL replacement therapy, ACUTE kidney failure
Abstract

Rationale: Allogeneic hematopoietic stem-cell transplantation (Allo-HSCT) recipients are still believed to be poor candidates for ICU management. Methods: We investigated outcomes and determinants of mortality in a large multicenter retrospective cohort of Allo-HSCT patients admitted between January 1, 2015, and December 31, 2020, to 14 French ICUs. The primary endpoint was 90-day mortality. Measurements and Main Results: In total, 1,164 patients were admitted throughout the study period. At the time of ICU admission, 765 (66%) patients presented with multiple organ dysfunction, including acute respiratory failure in 40% (n = 461). The median sepsis-related organ failure assessment score was 6 (interquartile range, 4–8). Invasive mechanical ventilation, renal replacement therapy, and vasopressors were required in 438 (38%), 221 (19%), and 468 (41%) patients, respectively. ICU mortality was 26% (302 deaths). Ninety-day, 1-year, and 3-year mortality rates were 48%, 63%, and 70%, respectively. By multivariable analysis, age > 56 years (odds ratio [OR], 2.0 [95% confidence interval (CI), 1.53–2.60]; P < 0.001), time from Allo-HSCT to ICU admission between 30 and 90 days (OR, 1.68 [95% CI, 1.17–2.40]; P = 0.005), corticosteroid-refractory acute graft-versus-host disease (OR, 1.63 [95% CI, 1.38–1.93]; P < 0.001), need for vasopressors (OR, 1.9 [95% CI, 1.42–2.55]; P < 0.001), and mechanical ventilation (OR, 3.1 [95% CI, 2.29–4.18]; P < 0.001) were independently associated with 90-day mortality. In patients requiring mechanical ventilation, mortality rates ranged from 39% (no other risk factors for mortality) to 100% (four associated risk factors for mortality). Conclusions: Most critically ill Allo-HSCT recipients survive their ICU stays, including those requiring mechanical ventilation, with an overall 90-day survival rate reaching 51.8%. A careful assessment of goals of care is required in patients with two or more risk factors for mortality. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study

Author

Gangneux, Jean-Pierre, Dannaoui, Eric, Fekkar, Arnaud, Luyt, Charles-Edouard, Botterel, Françoise, De Prost, Nicolas, Tadié, Jean-Marc, Reizine, Florian, Houzé, Sandrine, Timsit, Jean-François, Iriart, Xavier, Riu-Poulenc, Béatrice, Sendid, Boualem, Nseir, Saad, Persat, Florence, Wallet, Florent, Le Pape, Patrice, Canet, Emmanuel, Novara, Ana, Manai, Melek, Cateau, Estelle, Thille, Arnaud W, Brun, Sophie, Cohen, Yves, Alanio, Alexandre, Mégarbane, Bruno, Cornet, Muriel, Terzi, Nicolas, Lamhaut, Lionel, Sabourin, Estelle, Desoubeaux, Guillaume, Ehrmann, Stephan, Hennequin, Christophe, Voiriot, Guillaume, Nevez, Gilles, Aubron, Cécile, Letscher-Bru, Valérie, Meziani, Ferhat, Blaize, Marion, Mayaux, Julien, Monsel, Antoine, Boquel, Frédérique, Robert-Gangneux, Florence, Le Tulzo, Yves, Seguin, Philippe, Guegan, Hélène, Autier, Brice, Lesouhaitier, Matthieu, Pelletier, Romain, Belaz, Sorya, Bonnal, Christine, Berry, Antoine, Leroy, Jordan, François, Nadine, Richard, Jean-Christophe, Paulus, Sylvie, Argaud, Laurent, Dupont, Damien, Menotti, Jean, Morio, Florent, Soulié, Marie, Schwebel, Carole, Garnaud, Cécile, Guitard, Juliette, Le Gal, Solène, Quinio, Dorothée, Morcet, Jeff, Laviolle, Bruno, Zahar, Jean-Ralph, and Bougnoux, Marie-Elisabeth

Published
2022
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27. Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial

Author

Egle, Alexander, Greil, Richard, Joannidis, Michael, Lamprecht, Bernd, Altdorfer, Antoine, Belkhir, Leila, Fraipont, Vincent, Hites, Maya, Verschelden, Gil, Aboab, Jérôme, Ader, Florence, Ait-Oufella, Hafid, Andrejak, Claire, Andreu, Pascal, Argaud, Laurent, Bani-Sadr, Firouzé, Benezit, François, Blot, Mathieu, Botelho-Nevers, Elisabeth, Bouadma, Lila, Bouchaud, Olivier, Bougon, David, Bouiller, Kevin, Bounes-Vardon, Fanny, Boutoille, David, Boyer, Alexandre, Bruel, Cédric, Cabié, André, Canet, Emmanuel, Cazanave, Charles, Chabartier, Cyrille, Chirouze, Catherine, Clere-Jehl, Raphaël, Courjon, Johan, Crockett, Flora, Danion, François, Delbove, Agathe, Dellamonica, Jean, Djossou, Félix, Dubost, Clément, Duvignaud, Alexandre, Epaulard, Olivier, Epelboin, Loïc, Fartoukh, Murielle, Faure, Karine, Faure, Emmanuel, Ferry, Tristan, Ficko, Cécile, Figueiredo, Samy, Gaborit, Benjamin, Gaci, Rostane, Gagneux-Brunon, Amandine, Gallien, Sébastien, Garot, Denis, Geri, Guillaume, Gibot, Sébastien, Goehringer, François, Gousseff, Marie, Gruson, Didier, Hansmann, Yves, Hinschberger, Olivier, Jaureguiberry, Stéphane, Jeanmichel, Vanessa, Kerneis, Solen, Kimmoun, Antoine, Klouche, Kada, Lachâtre, Marie, Lacombe, Karine, Laine, Fabrice, Lanoix, Jean-Philippe, Launay, Odile, Laviolle, Bruno, Le Moing, Vincent, Le Pavec, Jérôme, Le Tulzo, Yves, Le Turnier, Paul, Lebeaux, David, Lefevre, Benjamin, Leroy, Sylvie, Lescure, François-Xavier, Lessire, Henry, Leveau, Benjamin, Loubet, Paul, Makinson, Alain, Malvy, Denis, Marquette, Charles-Hugo, Martin-Blondel, Guillaume, Martinot, Martin, Mayaux, Julien, Mekontso-Dessap, Armand, Meziani, Ferhat, Mira, Jean-Paul, Molina, Jean-Michel, Monnet, Xavier, Mootien, Joy, Mourvillier, Bruno, Murris-Espin, Marlène, Navellou, Jean-Christophe, Nseir, Saad, Oulehri, Walid, Peiffer-Smadja, Nathan, Perpoint, Thomas, Pialoux, Gilles, Pilmis, Benoît, Piriou, Vincent, Piroth, Lionel, Poissy, Julien, Pourcher, Valérie, Quenot, Jean-Pierre, Raffi, François, Reignier, Jean, Revest, Matthieu, Richard, Jean-Christophe, Riu-Poulenc, Béatrice, Robert, Céline, Roger, Pierre-Alexandre, Roger, Claire, Rouveix-Nordon, Elisabeth, Ruch, Yvon, Saidani, Nadia, Sayre, Naomi, Senneville, Eric, Sotto, Albert, Stefan, Francois, Tacquard, Charles, Terzi, Nicolas, Textoris, Julien, Thiery, Guillaume, Timsit, Jean-François, Tolsma, Violaine, Turmel, Jean-Marie, Valour, Florent, Wallet, Florent, Wattecamps, Guilhem, Yazdanpanah, Yazdan, Zerbib, Yoann, Berna, Marc, Reuter, Jean, Staub, Thérèse, Braz, Sandra, Ferreira Ribeiro, Joao-Miguel, Paiva, José-Artur, Roncon-Albuquerque, Roberto, Bouscambert-Duchamp, Maude, Gaymard, Alexandre, Lê, Minh-Patrick, Lina, Bruno, Peytavin, Gilles, Tubiana, Sarah, Couffin-Cadièrgues, Sandrine, Esperou, Hélène, Belhadi, Drifa, Burdet, Charles, Costagliola, Dominique, Dechanet, Aline, Delmas, Christelle, Diallo, Alpha, Fougerou, Claire, Guedj, Jérémie, Mentré, France, Mercier, Noémie, Noret, Marion, Saillard, Juliette, Velou, Priyanka, and Paiva, Jose-Artur

Published
2022
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28. An open-label randomized controlled trial of the effect of lopinavir/ritonavir, lopinavir/ritonavir plus IFN-β-1a and hydroxychloroquine in hospitalized patients with COVID-19

Author

Ader, Florence, Peiffer-Smadja, Nathan, Poissy, Julien, Bouscambert-Duchamp, Maude, Belhadi, Drifa, Diallo, Alpha, Delmas, Christelle, Saillard, Juliette, Dechanet, Aline, Mercier, Noémie, Dupont, Axelle, Alfaiate, Toni, Lescure, François-Xavier, Raffi, François, Goehringer, François, Kimmoun, Antoine, Jaureguiberry, Stéphane, Reignier, Jean, Nseir, Saad, Danion, François, Clere-Jehl, Raphael, Bouiller, Kévin, Navellou, Jean-Christophe, Tolsma, Violaine, Cabié, André, Dubost, Clément, Courjon, Johan, Leroy, Sylvie, Mootien, Joy, Gaci, Rostane, Mourvillier, Bruno, Faure, Emmanuel, Pourcher, Valérie, Gallien, Sébastien, Launay, Odile, Lacombe, Karine, Lanoix, Jean-Philippe, Makinson, Alain, Martin-Blondel, Guillaume, Bouadma, Lila, Botelho-Nevers, Elisabeth, Gagneux-Brunon, Amandine, Epaulard, Olivier, Piroth, Lionel, Wallet, Florent, Richard, Jean-Christophe, Reuter, Jean, Staub, Thérèse, Lina, Bruno, Noret, Marion, Andrejak, Claire, Lê, Minh Patrick, Peytavin, Gilles, Hites, Maya, Costagliola, Dominique, Yazdanpanah, Yazdan, Burdet, Charles, and Mentré, France

Published
2021
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30. Outcomes in patients treated with chimeric antigen receptor T-cell therapy who were admitted to intensive care (CARTTAS): an international, multicentre, observational cohort study

Author

Zafrani, Lara, Mariotte, Eric, Lemiale, Virginie, Arnulf, Bertrand, Boissel, Nicolas, Thieblemont, Catherine, Rabian, Florence, Harel, Stéphanie, Di Blasi, Roberta, Delgado, Julio, Ortiz, Valentin, Blaise, Didier, Fürst, Sabine, Legrand, Faezeh, Chabannon, Christian, Forcade, Edouard, Gros, François-Xavier, Borel, Cécile, Huynh, Anne, Récher, Christian, Rudzki, Jakob, Rakszawski, Kevin, Sesques, Pierre, Bachy, Emmanuel, Salles, Gilles, Perales, Miguel A, Wohlfarth, Philipp, Staudingert, Thomas, Jäger, Ulrich, Cartron, Guillaume, Fégueux, Nathalie, Ceballos, Patrice, Platon, Laura, Gastinne, Thomas, Tessoulin, Benoit, Le Bourgeois, Amandine, Gavrilina, Olga, Sureda, Anna, Mussetti, Alberto, Borrega, Jorge Garcia, Borchmann, Peter, Lin, Yi, Benjamin, Reuben, de Guibert, Sophie, Quelven, Quentin, Yakoub-Agha, Ibrahim, Beauvais, David, Rubio, Marie-Therese, Azoulay, Élie, Castro, Pedro, Maamar, Adel, Metaxa, Victoria, de Moraes, Alice Gallo, Voigt, Louis, Wallet, Florent, Klouche, Kada, Picard, Muriel, Moreau, Anne-Sophie, Van De Louw, Andry, Seguin, Amélie, Mokart, Djamel, Chawla, Sanjay, Leroy, Julien, Böll, Boris, Issa, Nahema, Levy, Bruno, Hemelaar, Pleun, Fernandez, Sara, Munshi, Laveena, Bauer, Philippe, Schellongowski, Peter, Joannidis, Michael, Moreno-Gonzalez, Gabriel, Galstian, Gennadii, Darmon, Michael, and Valade, Sandrine

Published
2021
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31. Weak Correlation Between Perceived and Measured Intensive Care Unit Nursing Workload: An Observational Study.

Author

Wallet, Florent, Bonnet, Audrey, Thiriaud, Vincent, Caillet, Anaelle, Piriou, Vincent, Vacheron, Charles-Hervé, Friggeri, Arnaud, and Dziadzko, Mikhail

Subjects
SCALE analysis (Psychology), PEARSON correlation (Statistics), MEDICAL quality control, INDUSTRIAL psychology, SCIENTIFIC observation, TERTIARY care, DESCRIPTIVE statistics, NURSING, LONGITUDINAL method, CONFIDENCE intervals, DATA analysis software, CRITICAL care nurses, SHIFT systems, ALGORITHMS
Abstract

Background: Efficient management of nursing workload in the intensive care unit (ICU) is essential for patient safety, care quality, and nurse well-being. Current ICU-specific workload assessment scores lack comprehensive coverage of nursing activities and perceived workload. Purpose: The purpose of this study was to assess the correlation between ICU nurses' perceived workload and the Nine Equivalents of Nursing Manpower Use Score (NEMS). Methods: In a 45-bed adult ICU at a tertiary academic hospital, nurses' perceived shift workload (measured with an 11-point Likert scale) was correlated with the NEMS, calculated manually and electronically. Results: The study included 1734 observations. The perceived workload was recorded for 77.6% of observations. A weak positive correlation was found between perceived and objectively measured workload. Conclusion: Findings indicate a need to consider the multifaceted nature of nursing activities and individual workload perceptions in the ICU. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Joint modeling of monocyte HLA‐DR expression trajectories predicts 28‐day mortality in severe SARS‐CoV‐2 patients.

Author

Baudemont, Gaelle, Tardivon, Coralie, Monneret, Guillaume, Cour, Martin, Rimmelé, Thomas, Garnier, Lorna, Yonis, Hodane, Richard, Jean‐Christophe, Coudereau, Remy, Gossez, Morgane, Wallet, Florent, Delignette, Marie‐Charlotte, Dailler, Frederic, Buisson, Marielle, Lukaszewicz, Anne‐Claire, Argaud, Laurent, Laouenan, Cédric, Bertrand, Julie, Venet, Fabienne, and Pescarmona, Remi

Subjects
HLA-DR antigens, SARS-CoV-2, COVID-19, INTENSIVE care units, JOINTS (Engineering)
Abstract

The recent SarsCov2 pandemic has disrupted healthcare system notably impacting intensive care units (ICU). In severe cases, the immune system is dysregulated, associating signs of hyperinflammation and immunosuppression. In the present work, we investigated, using a joint modeling approach, whether the trajectories of cellular immunological parameters were associated with survival of COVID‐19 ICU patients. This study is based on the REA‐IMMUNO‐COVID cohort including 538 COVID‐19 patients admitted to ICU between March 2020 and May 2022. Measurements of monocyte HLA‐DR expression (mHLA‐DR), counts of neutrophils, of total lymphocytes, and of CD4+ and CD8+ subsets were performed five times during the first month after ICU admission. Univariate joint models combining survival at day 28 (D28), hospital discharge and longitudinal analysis of those biomarkers' kinetics with mixed‐effects models were performed prior to the building of a multivariate joint model. We showed that a higher mHLA‐DR value was associated with a lower risk of death. Predicted mHLA‐DR nadir cutoff value that maximized the Youden index was 5414 Ab/C and led to an AUC = 0.70 confidence interval (95%CI) = [0.65; 0.75] regarding association with D28 mortality while dynamic predictions using mHLA‐DR kinetics until D7, D12 and D20 showed AUCs of 0.82 [0.77; 0.87], 0.81 [0.75; 0.87] and 0.84 [0.75; 0.93]. Therefore, the final joint model provided adequate discrimination performances at D28 after collection of biomarker samples until D7, which improved as more samples were collected. After severe COVID‐19, decreased mHLA‐DR expression is associated with a greater risk of death at D28 independently of usual clinical confounders. [ABSTRACT FROM AUTHOR]

Published
2024
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33. A retrospective comparison of COVID-19 and seasonal influenza mortality and outcomes in the ICUs of a French university hospital

Author

de Marignan, Donatien, Vacheron, Charles-Hervé, Ader, Florence, Lecocq, Maxime, Richard, Jean Christophe, Frobert, Emilie, Casalegno, Jean Sebastien, Couray-Targe, Sandrine, Argaud, Laurent, Rimmele, Thomas, Aubrun, Frédéric, Dailler, Frédéric, Fellahi, Jean Luc, Bohe, Julien, Piriou, Vincent, Allaouchiche, Bernard, Friggeri, Arnaud, and Wallet, Florent

Published
2022
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34. Critical COVID-19 Unveils the Link between Viral Particle Blood Dissemination and Prolonged Type I Interferon

Author

Saker, Kahina, primary, Mommert, Marine, additional, Oriol, Guy, additional, Generenaz, Laurence, additional, Cheynet, Valérie, additional, Bal, Antonin, additional, Bastard, Paul, additional, Casanova, Jean Laurent, additional, Roux, Emmanuel, additional, Brengel-Pesce, Karen, additional, Fleurie, Aurore, additional, Pons, Sylvie, additional, Barnel, Cécile, additional, Mokdad, Bouchra, additional, Wallet, Florent, additional, Terrier, Olivier, additional, Richard, Jean-Christophe, additional, and Assant, Sophie, additional

Published
2024
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36. Open-label randomized controlled trial of ultra-low tidal ventilation without extracorporeal circulation in patients with COVID-19 pneumonia and moderate to severe ARDS: study protocol for the VT4COVID trial

Author

Richard, Jean-Christophe, Yonis, Hodane, Bitker, Laurent, Roche, Sylvain, Wallet, Florent, Dupuis, Claire, Serrier, Hassan, Argaud, Laurent, Thiery, Guillaume, Delannoy, Bertrand, Pommier, Christian, Abraham, Paul, Muller, Michel, Aubrun, Frederic, Sigaud, Florian, Rigault, Guillaume, Joffredo, Emilie, Mezidi, Mehdi, Terzi, Nicolas, and Rabilloud, Muriel

Published
2021
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38. Non-invasive ventilation versus high-flow nasal cannula oxygen therapy with apnoeic oxygenation for preoxygenation before intubation of patients with acute hypoxaemic respiratory failure: a randomised, multicentre, open-label trial

Author

Chatellier, Delphine, Boissier, Florence, Veinstein, Anne, Robert, René, Deletage-Métreau, Céline, Olivry, Morgane, Dahyot-Fizelier, Claire, Dargent, Auguste, Large, Audrey, Begot, Emmanuelle, Mancia, Claire, Decavele, Maxence, Dres, Martin, Lehingue, Samuel, Papazian, Laurent, Paul, Marine, Marin, Nathalie, Le Meur, Matthieu, Laissy, Mohammed, Rouzé, Anaita, Nseir, Saad, Henry-Lagarrigue, Matthieu, Yehia, Aihem, Martino, Frédéric, Cerf, Charles, Bailly, Pierre, Helms, Julie, Putegnat, Jean Baptiste, Mekontso-Dessap, Armand, Boulain, Thierry, Asfar, Pierre, Cabasson, Séverin, Wallet, Florent, Klouche, Kada, Bellec, Frédéric, Frat, Jean-Pierre, Ricard, Jean-Damien, Quenot, Jean-Pierre, Pichon, Nicolas, Demoule, Alexandre, Forel, Jean-Marie, Mira, Jean-Paul, Coudroy, Rémi, Berquier, Guillaume, Voisin, Benoit, Colin, Gwenhaël, Pons, Bertrand, Danin, Pierre Eric, Devaquet, Jérome, Prat, Gwenael, Clere-Jehl, Raphaël, Petitpas, Franck, Vivier, Emmanuel, Razazi, Keyvan, Nay, Mai-Anh, Souday, Vincent, Dellamonica, Jean, Argaud, Laurent, Ehrmann, Stephan, Gibelin, Aude, Girault, Christophe, Andreu, Pascal, Vignon, Philippe, Dangers, Laurence, Ragot, Stéphanie, and Thille, Arnaud W

Published
2019
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39. Improved 30-Day Survival Estimation in ICU Patients: A Comparative Analysis of Different Approaches With Real-World Data

Author

Vacheron, Charles-Hervé, primary, Friggeri, Arnaud, additional, Gerbaud-Coulas, Chloe, additional, Dagonneau, Tristan, additional, Timsit, Jean Francois, additional, Allaouchiche, Bernard, additional, Wallet, Florent, additional, Bohe, Julien, additional, Piriou, Vincent, additional, Maucort-Boulch, Delphine, additional, and Fauvernier, Mathieu, additional

Published
2023
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41. Ultra-low tidal volume ventilation for COVID-19-related ARDS in France (VT4COVID): a multicentre, open-label, parallel-group, randomised trial

Author

Richard, Jean-Christophe, primary, Terzi, Nicolas, additional, Yonis, Hodane, additional, Chorfa, Fatima, additional, Wallet, Florent, additional, Dupuis, Claire, additional, Argaud, Laurent, additional, Delannoy, Bertrand, additional, Thiery, Guillaume, additional, Pommier, Christian, additional, Abraham, Paul, additional, Muller, Michel, additional, Sigaud, Florian, additional, Rigault, Guillaume, additional, Joffredo, Emilie, additional, Mezidi, Mehdi, additional, Souweine, Bertrand, additional, Baboi, Loredana, additional, Serrier, Hassan, additional, Rabilloud, Muriel, additional, Bitker, Laurent, additional, BOURDIN, Gaël, additional, VIVIER, Emmanuel, additional, LARGE, Audrey, additional, DONZE, Pierre, additional, BOUZGARROU, Radhia, additional, PERINEL RAGEY, Sophie, additional, CHAUDIER, Caroline, additional, DESEBBE, Olivier, additional, FOLLIET, Laure, additional, CHAUVELOT, Louis, additional, CHABERT, Paul, additional, DAVID, Guillaume, additional, DANJOU, William, additional, BETTINGER, Clotilde, additional, BERNON, Pauline, additional, DHELFT, Francois, additional, COUR, Martin, additional, SIMON, Marie, additional, BAUDRY, Thomas, additional, RIMMELE, Thomas, additional, CARABALONA, Jean-François, additional, GREGOIRE, Arnaud, additional, FRIGGERI, Arnaud, additional, DE-MARIGNAN, Donatien, additional, and ROCHE, Sylvain, additional

Published
2023
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42. Description of neurotoxicity in a series of patients treated with CAR T-cell therapy

Author

Belin, Catherine, Devic, Perrine, Ayrignac, Xavier, Dos Santos, Amélie, Paix, Adrien, Sirven-Villaros, Lila, Simard, Claire, Lamure, Sylvain, Gastinne, Thomas, Ursu, Renata, Berger, Colette, Platon, Laura, Tessoulin, Benoît, Azoulay, Elie, Wallet, Florent, Thieblemont, Catherine, Bachy, Emmanuel, Cartron, Guillaume, Laplaud, David A., and Carpentier, Antoine F.

Published
2020
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43. Association between SARS‐CoV‐2 viral kinetics and clinical score evolution in hospitalized patients.

Author

Néant, Nadège, Lingas, Guillaume, Gaymard, Alexandre, Belhadi, Drifa, Hites, Maya, Staub, Thérèse, Greil, Richard, Paiva, Jose‐Artur, Poissy, Julien, Peiffer‐Smadja, Nathan, Costagliola, Dominique, Yazdanpanah, Yazdan, Bouscambert‐Duchamp, Maude, Gagneux‐Brunon, Amandine, Ader, Florence, Mentré, France, Wallet, Florent, Burdet, Charles, and Guedj, Jérémie

Subjects
HOSPITAL patients, CORONAVIRUS disease treatment, EARLY warning score, COVID-19, VIRAL load
Abstract

The role of antiviral treatment in coronavirus disease 2019 hospitalized patients is controversial. To address this question, we analyzed simultaneously nasopharyngeal viral load and the National Early Warning Score 2 (NEWS‐2) using an effect compartment model to relate viral dynamics and the evolution of clinical severity. The model is applied to 664 hospitalized patients included in the DisCoVeRy trial (NCT04315948; EudraCT 2020‐000936‐23) randomly assigned to either standard of care (SoC) or SoC + remdesivir. Then we use the model to simulate the impact of antiviral treatments on the time to clinical improvement, defined by a NEWS‐2 score lower than 3 (in patients with NEWS‐2 <7 at hospitalization) or 5 (in patients with NEWS‐2 ≥7 at hospitalization), distinguishing between patients with low or high viral load at hospitalization. The model can fit well the different observed patients trajectories, showing that clinical evolution is associated with viral dynamics, albeit with large interindividual variability. Remdesivir antiviral activity was 22% and 78% in patients with low or high viral loads, respectively, which is not sufficient to generate a meaningful effect on NEWS‐2. However, simulations predicted that antiviral activity greater than 99% could reduce by 2 days the time to clinical improvement in patients with high viral load, irrespective of the NEWS‐2 score at hospitalization, whereas no meaningful effect was predicted in patients with low viral loads. Our results demonstrate that time to clinical improvement is associated with time to viral clearance and that highly effective antiviral drugs could hasten clinical improvement in hospitalized patients with high viral loads. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Use of 1,3-Beta-D-Glucan concentration in peritoneal fluid for the diagnosis of intra-abdominal Candidiasis in Critically-ill patients

Author

Nourry, Émilie, primary, Wallet, Florent, additional, Darien, Marie, additional, Menotti, Jean, additional, Dupont, Damien, additional, Allaouchiche, Bernard, additional, Argaud, Laurent, additional, Richard, Jean-Christophe, additional, Guichon, Céline, additional, Rimmelé, Thomas, additional, Bohe, Julien, additional, Thiollère, Fabrice, additional, Vassal, Olivia, additional, Lepape, Alain, additional, Wallon, Martine, additional, Persat, Florence, additional, and Friggeri, Arnaud, additional

Published
2023
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46. Suboptimal exposure to fluconazole in critically ill patients: Pharmacokinetic analysis and determinants

Author

Bienvenu, A.L., primary, Pradat, P., additional, Matusik, E., additional, Piriou, V., additional, Rimmelé, T., additional, Parant, F., additional, Tod, M., additional, Leboucher, G., additional, Goutelle, S., additional, Ader, Florence, additional, Argaud, Laurent, additional, Aubrun, Frédéric, additional, Fellahi, Jean-Luc, additional, Guichon, Céline, additional, Juillard, Laurent, additional, Leclerc, Vincent, additional, Miossec, Charline, additional, Paillet, Carole, additional, Plesa, Alexandra, additional, Richard, Jean-Christophe, additional, Roux, Sandrine, additional, and Wallet, Florent, additional

Published
2023
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50. Center effect in intubation risk in critically ill immunocompromised patients with acute hypoxemic respiratory failure

Author

Dumas, Guillaume, Demoule, Alexandre, Mokart, Djamel, Lemiale, Virginie, Nseir, Saad, Argaud, Laurent, Pène, Frédéric, Kontar, Loay, Bruneel, Fabrice, Klouche, Kada, Barbier, François, Reignier, Jean, Stoclin, Annabelle, Louis, Guillaume, Constantin, Jean-Michel, Wallet, Florent, Kouatchet, Achille, Peigne, Vincent, Perez, Pierre, Girault, Christophe, Jaber, Samir, Cohen, Yves, Nyunga, Martine, Terzi, Nicolas, Bouadma, Lila, Lebert, Christine, Lautrette, Alexandre, Bigé, Naike, Raphalen, Jean-Herlé, Papazian, Laurent, Benoit, Dominique, Darmon, Michael, Chevret, Sylvie, and Azoulay, Elie

Published
2019
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