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10. List of contributors

Author

Ahmad, Akil, primary, Araujo, A.R.T.S., additional, Ascenso, Andreia, additional, Asmak, Nurul, additional, Aziz, Zarith Asyikin Abdul, additional, Cabral, C., additional, Carvalheiro, Manuela, additional, Chuo, Sing Chuong, additional, Costa, Ana Margarida, additional, Dhawan, Vivek, additional, Dixit, Vaishali, additional, Faria-Silva, Ana Catarina, additional, Fernandes, Clara, additional, Guerra, C., additional, Happy, Afroza Akter, additional, Hoang Bui, Vu Khac, additional, Husain, Fahad Mabood, additional, Jahan, Ferdoushi, additional, Jawaid, Mohammad, additional, Kian, Lau Kia, additional, Lee, Young-Chul, additional, Lohani, Alka, additional, Marto, Joana, additional, Mascarenhas-Melo, F., additional, Mohd Setapar, Siti Hamidah, additional, Mohd-Nasir, Hasmida, additional, Mota, Ana Luísa, additional, Ndzotoyi, Phatheka, additional, Okole, Blessed, additional, Paiva-Santos, A.C., additional, Peixoto, D., additional, Peng, Wong Lee, additional, Pereira, Galvina, additional, Phasha, Vivey, additional, Pillai, Sreejarani Kesavan, additional, Reis, Catarina, additional, Ribeiro, Helena Margarida, additional, Rodrigues, M., additional, Siddique, Jamal Akhter, additional, Silva, Ana Margarida, additional, Simões, Sandra, additional, Singh, Manisha, additional, Thi Tran, Nhu Hoa, additional, Tran, Vinh Van, additional, Veiga, F., additional, Verma, Anurag, additional, and Vu Nu, Truong Thi, additional

Published
2022
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11. Treatment Avenues for Age-Related Macular Degeneration: Breakthroughs and Bottlenecks.

Author

Kumbhar, P, Kolekar, K, Vishwas, S, Shetti, P, Kumbar, V, Andreoli Pinto, TDJ, Paiva-Santos, AC, Veiga, F, Gupta, G, Singh, SK, Dua, K, Disouza, J, Patravale, V, Kumbhar, P, Kolekar, K, Vishwas, S, Shetti, P, Kumbar, V, Andreoli Pinto, TDJ, Paiva-Santos, AC, Veiga, F, Gupta, G, Singh, SK, Dua, K, Disouza, J, and Patravale, V

Abstract

Age-related macular degeneration (AMD) is a significant factor contributing to serious vision loss in adults above 50. The presence of posterior segment barriers serves as chief roadblocks in the delivery of drugs to treat AMD. The conventional treatment strategies use is limited due to its off-targeted distribution in the eye, shorter drug residence, poor penetration and bioavailability, fatal side effects, etc. The above-mentioned downside necessitates drug delivery using some cutting-edge technology including diverse nanoparticulate systems and microneedles (MNs) which provide the best therapeutic delivery alternative to treat AMD efficiently. Furthermore, cutting-edge treatment modalities including gene therapy and stem cell therapy can control AMD effectively by reducing the boundaries of conventional therapies with a single dose. This review discusses AMD overview, conventional therapies for AMD and their restrictions, repurposed therapeutics and their anti-AMD activity through different mechanisms, and diverse barriers in drug delivery for AMD. Various nanoparticulate-based approaches including polymeric NPs, lipidic NPs, exosomes, active targeted NPs, stimuli-sensitive NPs, cell membrane-coated NPs, inorganic NPs, and MNs are explained. Gene therapy, stem cell therapy, and therapies in clinical trials to treat AMD are also discussed. Further, bottlenecks of cutting-edge (nanoparticulate) technology-based drug delivery are briefed. In a nutshell, cutting-edge technology-based therapies can be an effective way to treat AMD.

Published
2024

13. Androgen deprivation therapy in patients with localized disease: Comparison with curative intent treatments and time to castration resistance. Results of the Spanish Prostate Cancer Registry

Author

Pórtela, P., Blanco, E., González, J.A., Baena, V., Morales, P., Villavicencio, H., Palou, J., Loizaga, A., Ciudin, A., Mihai, D., Martínez Jabaloyas, J.M., Castelló, A., Díez, N., Romero, F.J., Subirá, J., Chávez, A.I., Capapé, V., Mata, M., Elizalde, J., Lobato, J.J., Jiménez, J., Pérez Llorca, L., Tenza, J.A., Herranz, F., Husillos, A., López, E., Ramírez, D., Blaha, I., Izquierdo, E., Reina, L., Passas, J., Díez, L., Hevia, M.A., Castells, M., Concepción Masip, T., Plata, A.C., Asuar Aydillo, S., Alonso, J., Mateos, J., Carballido, J., Martínez, C., Areche, J., Rodríguez, R., Hevia, V., Álvarez, S., Requena, M.J., Prieto, R., Carazo, J.L., Márquez, J., Gómez, E., García, J.H., Amón, J., Cepeda, M., Álvarez, L., Rodríguez, V., de la Cruz, B., Rivero, A., Sánchez, J.F., Mainez, J.A., Medina, R., Conde, M., Castiñeiras, J., González Baena, A.C., Sánchez, E., Campanario, R., Saiz, R., Romero, E., Morote, J., Raventós, C.X., Celma, A., Vázquez, F., Gómez, A., Buendía, E., García, N., Garcia-Rodriguez, J., Fernandez-Gomez, J.M., Cozar, J.M., Miñana, B., Gomez-Veiga, F., and Rodriguez-Antolin, A.

Published
2020
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14. The impact of time from biopsy to radical prostatectomy on Gleason score undergrading and other related factors

Author

Virseda Rodríguez, A.J., Marcos Asensio, S., Herrero Polo, M., Hernández Sanchez, T., Sanz Ruiz, A., García, F., Vesga, F., Gutiérrez, E., Serrano, J.M., Calleja, J., Cortiñas, J.R., Zamora, A., Rodríguez, V., Amon Sesmero, J.H., Szczesniewski, R.J., Valverde Martínez, S., Polo López, C., Gala, L., Campanario, F., Barcina, A., López Aramburu, M.A., Moya, I., Bermúdez, R., and Gómez Veiga, F.

Published
2020
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26. Contributors

Author

Ahmed, Imteaz, primary, Ariga, Katsuhiko, additional, Deepracha, Siwada, additional, Fakhrullin, R., additional, Ferreira, C., additional, Hasan, Zubair, additional, Hashizume, Mineo, additional, Hsu, Shan-hui, additional, Imae, Toyoko, additional, Jhung, Sung Hwa, additional, Assefa Kebede, Mekuriaw, additional, Khan, Nazmul Abedin, additional, Li, Mao, additional, Lima, Renato Sousa, additional, Luo, Pei-wen, additional, Ogawa, Makoto, additional, Oliveira, Jr., Osvaldo N., additional, Patnaik, Archita, additional, Pereira, I., additional, Raymundo-Pereira, Paulo A., additional, Santos, A.C., additional, Shimizu, Flávio Makoto, additional, Veiga, F., additional, Vibulyaseak, Kasimanat, additional, Wang, Juan, additional, Xing, Ruirui, additional, and Yan, Xuehai, additional

Published
2019
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28. Direitos fundamentais na perspectiva italo-brasileira. Vol. IV

Author

F. Benatti (ORCID:0000-0002-7594-3199), Veiga, F., Benatti, Francesca, Viglione, F., F. Benatti (ORCID:0000-0002-7594-3199), Veiga, F., Benatti, Francesca, and Viglione, F.

Abstract

Il libro esamina l'incidenza della teoria dei diritti fondamentali nel diritto

Published
2023

29. Harnessing the neuroprotective effect of oral administration of benfotiamine in MPTP induced Parkinson's disease in rats.

Author

Bashir, B, Mittal, S, Muthukumar, A, Vishwas, S, Pandey, NK, Gulati, M, Gupta, G, Dhanasekaran, M, Kumar, P, Dureja, H, Veiga, F, Paiva-Santos, AC, Adams, J, Dua, K, Singh, SK, Bashir, B, Mittal, S, Muthukumar, A, Vishwas, S, Pandey, NK, Gulati, M, Gupta, G, Dhanasekaran, M, Kumar, P, Dureja, H, Veiga, F, Paiva-Santos, AC, Adams, J, Dua, K, and Singh, SK

Abstract

The study was performed to evaluate the neuroprotective effects of Benfotiamine (BFT) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) in rats. The rats were given daily doses of BFT (100mg/kg, 200mg/kg) through oral administration for 42 days. The rats were given a single bilateral dosage of MPTP (0.1 mg/nostril) intranasally once before the drug treatment to induce PD. On day 42, the animals were subjected to various behavioral paradigms. Post-treatment with BFT for 42 days significantly improved the motor and nonmotor fluctuations of MPTP. The results demonstrated that treatment with BFT ameliorated MPTP-induced disorders in behavior, body balance, and dopamine levels in the mid-brain. Among the post-treated groups, a high dose of BFT was the most effective treatment. Mean values are indicated in ±SEM, n = 5***(p < 0.001) when compared with the vehicle control, n = 5 ### (p < 0.001) when compared with the disease control; (p < 0.001) when compared with the BFT per se; (p < 0.001) when compared with the low dose of BFT; (p < 0.001) when compared with the high dose of BFT. Our finding suggests that BFT contributed to superior antioxidant, and anti-inflammatory and could be a novel therapeutic method for PD management. In conclusion, BFT could be a potential drug candidate for curbing and preventing PD.

Published
2023

30. Inorganic nanoparticles in dermopharmaceutical and cosmetic products: properties, formulation development, toxicity, and regulatory issues.

Author

Mascarenhas-Melo, F, Mathur, A, Murugappan, S, Sharma, A, Tanwar, K, Dua, K, Kumar Singh, S, Gava Mazzola, P, Nagalaxmi Yadav, D, Kumar Rengan, A, Veiga, F, Cláudia Paiva-Santos, A, Mascarenhas-Melo, F, Mathur, A, Murugappan, S, Sharma, A, Tanwar, K, Dua, K, Kumar Singh, S, Gava Mazzola, P, Nagalaxmi Yadav, D, Kumar Rengan, A, Veiga, F, and Cláudia Paiva-Santos, A

Abstract

The use of nanotechnology strategies is a current hot topic, and research in this field has been growing significantly in the cosmetics industry. Inorganic nanoparticles stand out in this context for their distinctive physicochemical properties, leading in particular to an increased refractive index and absorption capacity giving them a broad potential for cutaneous applications and making them of special interest in research for dermopharmaceutical and cosmetic purposes. This performance is responsible for its heavy inclusion in the manufacture of skin health products such as sunscreens, lotions, beauty creams, skin ointments, makeup, and others. In particular, their suitable bandgap energy characteristics allow them to be used as photocatalytic semiconductors. They provide excellent UV absorption, commonly known as UV filters, and are responsible for their wide worldwide use in sunscreen formulations without the undesirable white residue after consumer application. In addition, cosmetics based on inorganic nanoparticles have several additional characteristics relevant to formulation development, such as being less expensive compared to other nanomaterials, having greater stability, and ensuring less irritation, itching, and propensity for skin allergies. This review will address in detail the main inorganic nanoparticles used in dermopharmaceutical and cosmetic products, such as titanium dioxide, zinc oxide, silicon dioxide, silver, gold, copper, and aluminum nanoparticles, nanocrystals, and quantum dots, reporting their physicochemical characteristics, but also their additional intrinsic properties that contribute to their use in this type of formulations. Safety issues regarding inorganic nanoparticles, based on toxicity studies, both to humans and the environment, as well as regulatory affairs associated with their use in dermopharmaceuticals and cosmetics, will be addressed.

Published
2023

31. Topical delivery of nanoemulsions for skin cancer treatment

Author

Duarte, J, Sharma, A, Sharifi, E, Damiri, F, Berrada, M, Khan, MA, Singh, SK, Dua, K, Veiga, F, Mascarenhas-Melo, F, Pires, PC, Paiva-Santos, AC, Duarte, J, Sharma, A, Sharifi, E, Damiri, F, Berrada, M, Khan, MA, Singh, SK, Dua, K, Veiga, F, Mascarenhas-Melo, F, Pires, PC, and Paiva-Santos, AC

Published
2023

32. Interessi privati e interessi generali nelle stagioni del diritto civile

Author

Veiga, F, Viglione, F, Benatti, F, Portonera, Giuseppe, portonera (ORCID:0009-0007-7874-8368), Veiga, F, Viglione, F, Benatti, F, Portonera, Giuseppe, and portonera (ORCID:0009-0007-7874-8368)

Abstract

Il saggio abbozza alcune riflessioni intorno alla dialettica tra interessi privati e interessi generali nel sistema del diritto civile, servendosi a tale scopo anche di una prospettiva di ricostruzione storica.

Published
2023

33. Prefazione

Author

F. Veiga, F. Benatti, F. Viglione, Veiga, F., Benatti, Francesca, Viglione, F, F. Benatti (ORCID:0000-0002-7594-3199), F. Veiga, F. Benatti, F. Viglione, Veiga, F., Benatti, Francesca, Viglione, F, and F. Benatti (ORCID:0000-0002-7594-3199)

Abstract

La prefazione inquadra i due volumi e il loro significato

Published
2023

42. Probing insulin bioactivity in oral nanoparticles produced by ultrasonication-assisted emulsification/internal gelation

Author

Lopes MA, Abrahim-Vieira B, Oliveira C, Fonte P, Souza AMT, Lira T, Sequeira JAD, Rodrigues CR, Cabral LM, Sarmento B, Seiça R, Veiga F, and Ribeiro AJ

Subjects
Medicine (General), R5-920
Abstract

Marlene A Lopes,1,2,* Bárbara Abrahim-Vieira,3,* Claudia Oliveira,4,5 Pedro Fonte,6,7 Alessandra M T Souza,3 Tammy Lira,3 Joana A D Sequeira,1,2 Carlos R Rodrigues,3 Lúcio M Cabral,3 Bruno Sarmento,6–8 Raquel Seiça,9 Francisco Veiga,1,2 António J Ribeiro1,4,5 1Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal; 2CNC – Center for Neuroscience and Cell Biology, Coimbra, Portugal; 3Department of Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; 4I3S, Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal; 5Group Genetics of Cognitive Dysfunction, IBMC – Instituto de Biologia Molecular e Celular, Porto, Portugal; 6REQUIMTE, Department of Chemical Sciences – Applied Chemistry Lab, Faculty of Pharmacy, University of Porto, Porto, Portugal; 7CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Gandra, Portugal; 8INEB – Instituto de Engenharia Biomédica, University of Porto, Porto, Portugal; 9IBILI – Institute of Biomedical Research in Light and Image, Faculty of Medicine, University of Coimbra, Coimbra, Portugal *These authors contributed equally to this work Abstract: Alginate–dextran sulfate-based particles obtained by emulsification/internal gelation technology can be considered suitable carriers for oral insulin delivery. A rational study focused on the emulsification and particle recovery steps was developed in order to reduce particles to the nanosize range while keeping insulin bioactivity. There was a decrease in size when ultrasonication was used during emulsification, which was more pronounced when a cosurfactant was added. Ultrasonication add-on after particle recovery decreased aggregation and led to a narrower nanoscale particle-size distribution. Insulin encapsulation efficiency was 99.3%±0.5%, attributed to the strong pH-stabilizing electrostatic effect between insulin and nanoparticle matrix polymers. Interactions between these polymers and insulin were predicted using molecular modeling studies through quantum mechanics calculations that allowed for prediction of the interaction model. In vitro release studies indicated well-preserved integrity of nanoparticles in simulated gastric fluid. Circular dichroism spectroscopy proved conformational stability of insulin and Fourier transform infrared spectroscopy technique showed rearrangements of insulin structure during processing. Moreover, in vivo biological activity in diabetic rats revealed no statistical difference when compared to nonencapsulated insulin, demonstrating retention of insulin activity. Our results demonstrate that alginate–dextran sulfate-based nanoparticles efficiently stabilize the loaded protein structure, presenting good physical properties for oral delivery of insulin. Keywords: biopolymers, insulin secondary structure, microparticle, molecular modeling, nanoencapsulation processing, oral delivery

Published
2015

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