144 results on '"U. Han"'
Search Results
2. Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF-α-induced inflammatory activation of synovial fibroblasts
- Author
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Ruby J. Siegel, Anil K. Singh, Paul M. Panipinto, Farheen S. Shaikh, Judy Vinh, Sang U. Han, H. Mark Kenney, Edward M. Schwarz, Cynthia S. Crowson, Sadik A. Khuder, Basil S. Khuder, David A. Fox, and Salahuddin Ahmed
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Infectious Diseases ,Immunology ,Immunology and Allergy - Published
- 2022
3. Enhancing the Photocatalytic Hydrogen Evolution Performance of the CsPbI3/MoS2 Heterostructure with Interfacial Defect Engineering
- Author
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Chol-Hyok Ri, Hyon-U Han, Yun-Sim Kim, Un-Gi Jong, Yun-Hyok Kye, and Chol-Jun Yu
- Subjects
General Materials Science ,Physical and Theoretical Chemistry - Published
- 2022
4. Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF-α-induced inflammatory activation of synovial fibroblasts
- Author
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Ruby J, Siegel, Anil K, Singh, Paul M, Panipinto, Farheen S, Shaikh, Judy, Vinh, Sang U, Han, H Mark, Kenney, Edward M, Schwarz, Cynthia S, Crowson, Sadik A, Khuder, Basil S, Khuder, David A, Fox, and Salahuddin, Ahmed
- Subjects
Tumor Necrosis Factor-alpha ,Synovial Membrane ,JNK Mitogen-Activated Protein Kinases ,DNA ,Fibroblasts ,Ligands ,Receptors, Tumor Necrosis Factor ,Arthritis, Rheumatoid ,Transcription Factor AP-1 ,Mice ,Protein Kinase C-delta ,Animals ,Humans ,RNA, Small Interfering ,Sulfatases ,Cells, Cultured - Abstract
Extracellular sulfatase-2 (Sulf-2) influences receptor-ligand binding and subsequent signaling by chemokines and growth factors, yet Sulf-2 remains unexplored in inflammatory cytokine signaling in the context of rheumatoid arthritis (RA). In the present study, we characterized Sulf-2 expression in RA and investigated its potential role in TNF-α-induced synovial inflammation using primary human RA synovial fibroblasts (RASFs). Sulf-2 expression was significantly higher in serum and synovial tissues from patients with RA and in synovium and serum from hTNFtg mice. RNA sequencing analysis of TNF-α-stimulated RASFs showed that Sulf-2 siRNA modulated ~2500 genes compared to scrambled siRNA. Ingenuity Pathway Analysis of RNA sequencing data identified Sulf-2 as a primary target in fibroblasts and macrophages in RA. Western blot, ELISA, and qRT‒PCR analyses confirmed that Sulf-2 knockdown reduced the TNF-α-induced expression of ICAM1, VCAM1, CAD11, PDPN, CCL5, CX3CL1, CXCL10, and CXCL11. Signaling studies identified the protein kinase C-delta (PKCδ) and c-Jun N-terminal kinase (JNK) pathways as key in the TNF-α-mediated induction of proteins related to cellular adhesion and invasion. Knockdown of Sulf-2 abrogated TNF-α-induced RASF proliferation. Sulf-2 knockdown with siRNA and inhibition by OKN-007 suppressed the TNF-α-induced phosphorylation of PKCδ and JNK, thereby suppressing the nuclear translocation and DNA binding activity of the transcription factors AP-1 and NF-κBp65 in human RASFs. Interestingly, Sulf-2 expression positively correlated with the expression of TNF receptor 1, and coimmunoprecipitation assays demonstrated the binding of these two proteins, suggesting they exhibit crosstalk in TNF-α signaling. This study identified a novel role of Sulf-2 in TNF-α signaling and the activation of RA synoviocytes, providing the rationale for evaluating the therapeutic targeting of Sulf-2 in preclinical models of RA.
- Published
- 2021
5. Ab initio study of superoxide dismutase (SOD) and catalase activity of EUK-134
- Author
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Mun-Hyok Ri, Un-Son Ri, Hyon-U. Han, Son-Yong Ko, Nam-Hyok Kim, Kyong-Song Jang, Kyong-Il Kim, and Yun-Sop Sin
- Subjects
Inorganic Chemistry ,Computational Theory and Mathematics ,Superoxide Dismutase ,Superoxides ,Organic Chemistry ,Organometallic Compounds ,Hydrogen Peroxide ,Physical and Theoretical Chemistry ,Catalase ,Catalysis ,Antioxidants ,Salicylates ,Computer Science Applications - Abstract
Dismutation reaction of superoxide radical catalyzed by EUK-134 has lower activation energy than non-catalytic reaction, and therefore, EUK-134 catalyzes dismutation reaction of superoxide radical. For non-catalytic dismutation reaction of hydrogen peroxide, there are three possible reaction paths, among which MEP3 has the lowest activation energy, and therefore, is thought to be the most probable reaction path. Dismutation reaction of hydrogen peroxide catalyzed by EUK-134 occurs in two successive steps and has lower energy barrier than non-catalytic dismutation reaction, and therefore, EUK-134 is thought to catalyze the dismutation reaction of hydrogen peroxide. HOMO (highest occupied molecular orbital) and LUMO (lowest unoccupied molecular orbital) and ESP-fitted charge analysis of EUK-134 indicate that Mn atom plays an electron acceptor and donor for dismutation reactions of superoxide radical and hydrogen peroxide catalyzed by EUK-134, respectively.
- Published
- 2021
6. DNA barcodes and morphology reveal two new species of Monodiamesa Kieffer (Diptera: Chironomidae: Prodiamesinae) in Tibetan Plateau
- Author
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W U Han, Hongqu Tang, and Zhenyu Ni
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0106 biological sciences ,Male ,Insecta ,Arthropoda ,Ecology (disciplines) ,010607 zoology ,Zoology ,Morphology (biology) ,Tibet ,010603 evolutionary biology ,01 natural sciences ,DNA barcoding ,Chironomidae ,Animalia ,Animals ,DNA Barcoding, Taxonomic ,Ecology, Evolution, Behavior and Systematics ,Ecosystem ,Taxonomy ,geography ,Plateau ,geography.geographical_feature_category ,biology ,Diptera ,Prodiamesinae ,Biodiversity ,biology.organism_classification ,Habitat ,Animal Science and Zoology ,Female ,Monodiamesa - Abstract
Two Monodiamesa species collected in all stages and both sexes from the Tibetan Plateau are erected as M. secunditibetica Han and Tang, sp. n. and M. bonalpicola Han and Tang, sp. n. Molecular analysis of barcodes (COI-5P) for some related known species confirms the species validity and allows inference of internal relationships. Detailed description, habitat ecology and geographical information of two new species are provided. Additionally, brief comments on some known eastern Palaearctic species of Monodiamesa are made to give insights on further study.
- Published
- 2021
7. Assessment of the intrasinusidal volume before and after maxillary sinus augmentation using mri – a pilot study of eight patients
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K. Flick, R. Smeets, M. Gosau, L. Meyer, U. Hanning, A. A. Kyselyova, C. Scheifele, B. Höhmann, and A. Henningsen
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Magnetic resonance imaging ,Sinus floor augmentation ,Maxillary sinus graft ,Dental implants ,3 T ,MRI ,Dentistry ,RK1-715 - Abstract
Abstract Purpose The purpose of this study was to evaluate the suitability, accuracy, and reliability of a non-invasive 3-Tesla magnetic resonance imaging technique (3 T-MRI) for the visualization of maxillary sinus grafts in comparison to conventional, X-ray-based, established standard imaging techniques. Methods A total of eight patients with alveolar bone atrophy who required surgical sinus floor augmentation in the course of dental implantation were included in this pilot study. Alongside pre-operative cone-beam computed tomography (CBCT), 3 T-MRI was performed before and 6 months after sinus floor augmentation. Two investigators measured the maxillary sinus volume preoperatively and after bone augmentation. Results In all cases, MRI demonstrated accurately the volumes of the maxillary sinus grafts. Following surgery, the bony structures suitable for an implant placement increased at an average of 4.89 cm3, corresponding with the decrease of the intrasinusidal volumes. In general, interexaminer discrepancies were low and without statistical significance. Conclusion In this preliminary study, we could demonstrate the feasibility of MRI bone volume measurement as a radiation-free alternative with comparable accuracy to CT/CBCT before procedures like sinus floor augmentation. Nevertheless, costs and artifacts, also present in MRI, have to be taken into account. Larger studies will be necessary to justify the practicability of MRI bone volume evaluation.
- Published
- 2024
- Full Text
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8. Phylogeny of marine Ainuyusurika tuberculata (Tokunaga) (Diptera: Chironomidae: Chironominae), with description of the immature stages
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Hongqu Tang and W U Han
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China ,Insecta ,Arthropoda ,Zoology ,Chironomidae ,Phylogenetics ,Genus ,Sasa ,Animals ,Animalia ,Ecology, Evolution, Behavior and Systematics ,Phylogeny ,Taxonomy ,Larva ,biology ,Diptera ,Pupa ,Polypedilum ,Bayes Theorem ,Biodiversity ,biology.organism_classification ,Chironominae ,Animal Science and Zoology - Abstract
The marine Chironomidae Ainuyusurika Sasa et Shirasaka, 1988, previously known from the adults only, is associated with its immature stages for the first time based on reared specimens from Oriental China. The larva resembles those of Sergentia Kieffer and Endochironomus Kieffer in the ventromental plate with an anteromedial projection and the 5-segmented antenna with opposite Lauterborn organs. The pupal thoracic horn has 12 branches at maximum and netted tergite spinulation which appears to be similar to those of Polypedilum Kieffer, Endotribelos Grodhaus, Phaenopsectra Kieffer and Sergentia. The phylogenetic relationship was furtherly explored through molecular analysis based on concatenation of five gene makers (18S, 28S, CAD1, CAD4 and COI-3P) using both mixed-model Bayesian and maximum likelihood inference methods. The result shows Ainuyusurika is nested with an assemblage of Endochironomus, Phaenopsectra and Endotribelos. We concluded that Ainuyusurika is a good independent genus showing affinity with Endochironomus-Phaenopsectra related genera.
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- 2019
9. Growth and Fruit Characteristics of Mini Watermelon in Different Cultivation Types and Plant Spacings
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Chong-U Han, Tae-Il Kim, Young-Sang Kim, Sol-Ji Noh, Ik-Jei Kim, Taek-Gu Jeong, and Seong-Taeg Hong
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Horticulture ,chemistry.chemical_compound ,chemistry ,General Medicine ,Biology ,Lycopene - Published
- 2018
10. Suppression of Powdery Mildew Using the Water Extract of Xylogone ganodermophthora and Aqueous Potassium Phosphonate Solution on Watermelon under Greenhouse Conditions
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Tae Il Kim, Chong U Han, Sang Young Nam, Young-Sang Kim, Hyo-Jung Kang, Ik-Jei Kim, and Taek Ku Jeong
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Aqueous solution ,Filter paper ,Spots ,Chemistry ,Potassium ,Fungicide ,chemistry.chemical_element ,Plant Science ,Biochemistry ,lcsh:S1-972 ,Conidium ,Horticulture ,Watermelon ,Powdery mildew ,Control ,Phytotoxicity ,lcsh:Agriculture (General) ,Agronomy and Crop Science ,Molecular Biology ,Biotechnology - Abstract
Xylogone ganodermophthora (Xg) is an ascomycetous fungus that causes yellow rot on cultivated Ganoderma lucidum. Previously, we reported in vitro antifungal activities of a Xg culture extract against several watermelon pathogens. In 2014, we conducted greenhouse experiments to evaluate the control efficacy of a water extract of cultured Xg on watermelon powdery mildew (WPM). The test material (stock solution, ca. 4,000 µg/ml) was prepared by an autoclaved Xg culture in water at a ratio of 800 g of culture per 6 liter of water, and then filtering it through filter paper. Six foliar applications of the solutions (diluted 100- and 1,000-fold) significantly suppressed the formation of conidiophores and conidia. The inhibitory effect of aqueous potassium phosphonate solution on the disease and its phytotoxicity was tested. Phytotoxicity on watermelon plants was observed at concentrations of 1,000 and 2,000 µg/ml as irregular brownish spots. The control efficacies against WPM were 91.9% at 2,000 µg/ml, 64.9% at 1,000 µg/ml, and 62.2% at 500 µg/ml.
- Published
- 2015
11. Characteristics of the Near-surface Atmospheric Electric Field over the Top of a Flat Mountain in Xilin Hot Volcano Geopark
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null U Han, null CHEN Tao, null LI Renkang, null HE Zhaohai, null ZHANG Huawei, null LUO Jing, null LUO Fushan, null WANG Naiquan, and null DONG Wei
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Complementary and alternative medicine ,Pharmaceutical Science ,Pharmacology (medical) - Published
- 2020
12. Mammographic and Ultrasonographic Findings of Different Breast Adenosis Lesions
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Emine Öztürk, G Seker, Baki Hekimoglu, Cüneyt Yücesoy, B Onal, and U Han
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lcsh:Medical physics. Medical radiology. Nuclear medicine ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,lcsh:R895-920 ,mammography ,Ultrasound ,ultrasonography ,Breast Adenosis ,adenosis ,Acoustic shadow ,Breast, adenosis, ultrasonography, mammography ,Pathognomonic ,Biopsy ,Medicine ,Mammography ,Original Article ,Breast ,Radiology ,Ultrasonography ,business ,Pathological - Abstract
Aim: To describe imaging features of different breast adenosis lesions. Materials and methods: Mammographic and ultrasonographic findings of patients with different types of adenosis were reviewed retrospectively Tissue samples were obtained either with US-guided core needle biopsy or localization with needle-wire system and surgical excision. Results: Forty-three adenosis lesions were diagnosed in 41 patients: 27 sclerosing adenosis, 13 blunt duct adenosis and 3 microglandular adenosis. Most frequent abnormal findings of sclerosing adenosis were masses with non-circumscribed margins and focal acoustic shadowing without mass configuration (54%) on ultrasonography. Mammography was normal in 54% of sclerosing adenosis, the most common abnormality was architectural distortion (21%). In blunt duct adenosis, usually circumscribed masses (46%) were detected on ultrasonography, clustered punctate microcalcifications (23%) and circumscribed masses (23%) were observed on mammography. All microglandular adenosis lesions were non-circumscribed masses. Premalignant components were detected only with surgical excisional biopsy in three patients that showed suspicious radiological findings and benign pathological result on core biopsy. Conclusion: The adenosis lesions have no pathognomonic characteristics on mammography and ultrasound. Total excision may be considered when suspicious radiological findings are present although core needle biopsy results are benign.
- Published
- 2015
13. Investigation of Chemical Properties of the Jujube Orchard Soils at Boeun Region in Chungbuk
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Gyeong-Ja Lee, Ik-Hwan Kim, Jong-U Han, Bo-Goo Kang, and Ki-Sik Kim
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chemistry.chemical_classification ,Soil test ,Nutrient management ,General Medicine ,engineering.material ,Phosphate ,chemistry.chemical_compound ,Horticulture ,Geography ,Nutrient ,Agronomy ,chemistry ,Soil water ,engineering ,Organic matter ,Fertilizer ,Orchard - Abstract
BACKGROUND: Recently, as the consumption of fresh jujube is increased, fertilizer in jujube cultivation is excessively used to supply nutrient for large fruit produce. This study was conducted to obtain the useful data related to optimum nutrient management technique for fresh jujube cultivation. METHODS AND RESULTS: Nutrient contents of the jujube orchard soils were investigated at 30 different jujube orchards in Boeun, Chungbuk. Soil samples were collected from the different orchards in June, both 2012 and 2013. Soil chemical properties such as pH, organic matter, available phosphate, and exchangeable potassium, calcium, and magnesium were analyzed. Soil available phosphates in optimum level for jujube cultivation were 7% and 13% of total samples in the 2011 and 2012 respectively, and 73% and 57% were higher than optimum level. In Exchangeable K, 37%, 30% were optimum level, 63%, 67% were higher in the year 2011 and 2012 respectively. CONCLUSION: These results showed that nutrient contents of soils were accumulated in jujube orchard of Boeun area. Especially, available phosphate and exchangeable potassium were greatly higher than their optimum level for jujube cultivation respectively.
- Published
- 2014
14. Investigation of Nutrient Contents in Jujube and Its Orchard Soils under Pesticide-Free Cultivation in Boeun Region
- Author
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Ik-Hwan Kim, Bo-Goo Kang, Jong-U Han, Gyeong-Ja Lee, Ki-Sik Kim, and Hyun-Zoo Kim
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chemistry.chemical_compound ,Horticulture ,Nutrient ,Geography ,Agronomy ,Nitrate ,chemistry ,Nutrient management ,Soil water ,Jujube Fruit ,Orchard ,Pesticide ,Ion content - Abstract
To obtain the useful data related to optimum nutrient management technique for pesticides-free jujube cultivation, nutrient contents of jujube leaves and fruits and the selected chemical properties of jujube orchard soils were investigated at 9 different orchards with pesticides-free cultivation in Boeun, Chungbuk, Korea. Soil and jujube leaf samples were collected from the different orchards in July and October, and jujube fruit samples were taken in October, 2012. Soil available P2O5 contents in the optimum level for jujube cultivation were 11% and 33% of total samples in July and October, respectively, but 56% of total samples was higher than the optimum level in both July and October. Exchangeable K and Ca ion contents were 44% and 67% of total samples, respectively, in both July and October, whereas exchangeable Mg ion content was 100% and 56% of total samples in July and October, respectively. Nutrient contents in jujube leaves were higher than those in fresh fruits. In addition, total nitrate, potassium and magnesium contents in the jujube leaves were higher in the samples collected in July than in October.
- Published
- 2013
15. Effect of local use of <scp>l</scp>-carnitine after myringotomy on myringosclerosis development in rats
- Author
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S Alicura Tokgöz, Ömer Beşalti, Istemihan Akin, U Han, Fulya Köybaşıoğlu, Gökçe Şimşek, Murat Çalişkan, and Erkan Vuralkan
- Subjects
Male ,Myringosclerosis ,business.industry ,Administration, Topical ,medicine.medical_treatment ,Membrane thickness ,General Medicine ,Middle Ear Ventilation ,Rats ,Myringotomy ,Otorhinolaryngology ,Tympanic Membranes ,Carnitine ,Anesthesia ,medicine ,Animals ,Thickening ,Rats, Wistar ,business ,After treatment ,medicine.drug - Abstract
Objectives:This study aimed to investigate the effect of local and intraperitoneal administration of l-carnitine on the prevention of experimentally induced myringosclerosis, and to compare treatment efficiency.Methods:Twenty-four Albino-Wistar rats (48 ears) were bilaterally myringotomised and divided randomly into four groups: group one received no treatment, group two received intraperitoneal l-carnitine, group three received local l-carnitine, and group four received both intraperitoneal and local l-carnitine. On the 15th day after treatment, tympanic membranes were harvested and evaluated histopathologically for myringosclerotic plaque formation, fibroblastic proliferation, tympanic membrane thickness and new vessel formation.Results:The group one tympanic membranes showed extensive thickness, and the incidence of myringosclerosis and fibroblast proliferation were greater than in groups two and four. There were statistically significant differences in tympanic membrane thickness between groups three and four, and in myringosclerosis incidence and fibroblast proliferation, comparing groups two, three and four.Conclusion:Myringosclerosis development was significantly reduced in rats receiving myringotomy plus intraperitoneal l-carnitine. Intraperitoneal l-carnitine administration prevented fibroblastic proliferation and tympanic membrane thickening (both of which cause further tympanic membrane destruction), thus reducing myringotomy-associated morbidity. Local l-carnitine administration had limited effectiveness in this experimental setting.
- Published
- 2013
16. IASGO World Congress
- Author
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C.L. Yong and S.-U. Han
- Published
- 2016
17. Damage Analysis and Establishment of Control Threshold for Phytophthora Blight of Hot Pepper (Capsicum annuum)
- Author
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Hyo-Jung Kang, Ki-Su Ahn, Yee-Gi Kim, Sang Hee Kim, Kyeong-Heon Jeong, and Chong-U Han
- Subjects
Capsicum annuum ,biology ,fungi ,Fresh weight ,Damage analysis ,food and beverages ,Control threshold ,Plant Science ,biology.organism_classification ,lcsh:S1-972 ,Biochemistry ,Horticulture ,Phytophthora capsici ,Agronomy ,Yield (wine) ,Pepper ,Blight ,lipids (amino acids, peptides, and proteins) ,Phytophthora ,lcsh:Agriculture (General) ,Agronomy and Crop Science ,Molecular Biology ,Biotechnology - Abstract
Incidence of Phytophthora blight of hot pepper (Capsicum annuum) and yield (fresh weight) of pepper fruits were investigated at four separate fields located in Cheongwon, Boeun, Eumsung, and Goesan, which are major pepper production areas in Chungcheongbuk-Do. In all of the experimental fields except the Goesan field, increased incidence of Phytophthora blight led to decreased yield of pepper fruits. The harvest time in which the yield of red pepper fruits was highly correlated with the incidence of Phytophthora blight was different between areas: it was highly correlated in the third harvest in Cheongwon (y=-11.0x+435.2, r2= 0.99), but in the second harvest in Boeun (y=-15.0x+944.6, r2=0.76). In contrast, there was a very low correlation between the pepper yield and the disease incidence in Goesan in which pepper seedlings grafted on resistant stocks were planted. The final disease incidence in the Cheongwon experimental field reached 100% more than 40 days later in 2007 compared with that in 2006. The control threshold of Phytophthora blight in the pepper fields where disease incidence had been lower than 5% was set as 0.8% disease incidence, which caused less than 5% yield loss
- Published
- 2011
18. Analysis of the Factors Involved in the Occurrence of Rice Stripe virus in Chungcheongbukdo in 2008 and 2009
- Author
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Ki-Su Ahn, Jeong-Soo Kim, See-Jung Park, Hyo-Jung Kang, Jae-Jun Ji, Chong-U Han, and Kyeong-Heon Jeong
- Subjects
education.field_of_study ,Veterinary medicine ,Population ,Adult population ,food and beverages ,Rice stripe virus ,Plant Science ,Biology ,biology.organism_classification ,Biochemistry ,Population density ,Virology ,Infection rate ,Paddy field ,Host plants ,education ,Agronomy and Crop Science ,Molecular Biology ,Biotechnology - Abstract
The occurrence factors of Rice stripe virus (RSV) in Chungcheongbukdo were analyzed by investigating the viruliferous insect rate (VIR) of overwintered small brown plant hopper (SBPH), the population density of SBPH, the infection rate of natural host plants, and the occurrence rate of RSV on rice paddy fields at the 3 areas of Cheongwon, Jincheon, and Boeun in 2008 and 2009. The average VIR of overwintered SBPH was 0.0% in 2008 and 1.1% in 2009. From SBPH collected on early June in 2009, VIR was higher as 1.4% at Jincheon and 4.2% at Boeun than those of overwintered SBPH, and this higher VIR might relate stronlgy with the adult population of SBPH immigrated from China. The populations of SBPH at Cheongwon, Jincheon and Boeun in 2008 were 3.8, 7.5 and 20.8 Head/, respectively. However, those of Cheongwon and Jincheon increased up to about two folds as 8.4 and 13.1 in 2009. No RSV was detected on the natural host plants including barley. The factors involved in RSV occurrence were affected negatively by the low VIR of overwintered SBPH, the low population of overwintered SBPH, the low infection rate of RSV on the natural host plants, and the clean cultivation environment in Chungcheongbukdo.
- Published
- 2010
19. Contents Vol. 43, 2009
- Author
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Frasko R, Chalbi Belkahia, E. Plouvier, F. Thuillier, V. Rumenjak, Xavier Forceville, Volker Huge, A. Combes, D. Ben Saîd, Michael Vogeser, R. Ben Ali, Manfred Thiel, Dražen Vnuk, Nadia Kourda, Alexander Choukèr, V. Mostert, A. Castagnoli, Emna Gaïes, M.T. Oruç, Fabio Davoli, P. Le Toumelin, Wieland Raue, U. Han, Anis Klouz, Patrizia Campolongo, Jens Hartmann, P. Maruna, Jury Brandolini, D. Vitoux, Josip Kos, Z. Krstonijević, Mohamed Lakhal, Benedetta Bedetti, Daniela Hauer, Ž. Rašić, F. Sellitri, Jaroslav Lindner, N. Elkadri, V. Nesek-Adam, Gustav Schelling, Giampiero Dolci, A. Bloch, Franco Stella, M.M. Özmen, A. Pierantoni, Charalambos Menenakos, Nikolaos Tsilimparis, Ines Kaufmann, and M. Dehoux
- Subjects
Traditional medicine ,business.industry ,Physiology ,Medicine ,Surgery ,business - Published
- 2009
20. Recovery of negative bias temperature instability induced degradation of p-MOSFETs with SiON gate dielectric
- Author
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Youn-Jang Kim, Bongkoo Kang, Hong Seok Kang, and S. U. Han
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Silicon oxynitride ,Negative-bias temperature instability ,Materials science ,Passivation ,business.industry ,Gate dielectric ,Electron ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,chemistry.chemical_compound ,chemistry ,Electron injection ,MOSFET ,Optoelectronics ,Degradation (geology) ,Electrical and Electronic Engineering ,business - Abstract
This paper investigates the recovery property of p-MOSFETs with an ultra-thin SiON gate dielectric which are degraded by negative bias temperature instability (NBTI). The experimental results indicate that the recovery of the NBTI degradation occurs through an electrical neutralization of the NBTI-induced positive charges at the SiON/Si interface and in the gate dielectric. The neutralization of interface charges was a fast process occurring just after the device returned to the recovery state. The neutralization of positive charges in the gate dielectric was a slow process associated with the electron injection into the gate dielectric. Below the gate voltage for strong accumulation, the amount of recovery increased with an increase of the gate voltage. A further increase of gate voltage did not affect the amount of recovery. These experimental results indicate that the major cause of the recovery is a neutralization of the NBTI-induced positive charges by electrons instead of a hydrogen passivation of the NBTI-induced defect sites.
- Published
- 2008
21. Time-dependent degradation due to negative bias temperature instability of p-MOSFET with an ultra-thin SiON gate dielectric
- Author
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Bongkoo Kang, H. S. Kang, and S. U. Han
- Subjects
Negative-bias temperature instability ,Silicon oxynitride ,Hydrogen ,Diffusion ,Gate dielectric ,Analytical chemistry ,chemistry.chemical_element ,Condensed Matter Physics ,Nitrogen ,Atomic and Molecular Physics, and Optics ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,chemistry.chemical_compound ,chemistry ,MOSFET ,Degradation (geology) ,Electrical and Electronic Engineering - Abstract
This paper presents the time-dependence of the negative bias temperature instability (NBTI) degradation of p-MOSFETs with an ultra-thin silicon oxynitride gate dielectric. The concentrations of nitrogen in the gate dielectric were approximately 3% and 10%. The device with 10% nitrogen concentration had unique time-dependent degradation characteristics due to the nitrogen enhanced NBTI effect. It degraded significantly just after application of an NBTI stress. After this initial degradation, a fast and slow degradation followed in sequence. The initial, fast, and slow degradations appear to be associated with the deep donor effect of nitrogen, the diffusion of ionic and neutral hydrogen combined with Si-H bond breaking, and the diffusion of neutral hydrogen combined with O-H bond breaking, respectively. Owing to the slow down of the NBTI degradation after the initial and fast degradations, the lifetime for the device with 10% nitrogen concentration was three times longer than that with 3% nitrogen concentration.
- Published
- 2006
22. Simultaneous Expression of the Protease Inhibitors in a Rice Blast-Resistant Mutant
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Jae Soon Cha, Chan Hui Lee, Seon-Woo Lee, Kwang Yun Cho, Jae Eul Choi, Jin-Cheol Kim, Gyung Ja Choi, Sang-Nag Ahn, and Chong U Han
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Genetics ,endocrine system ,Protease ,Inoculation ,medicine.medical_treatment ,Mutant ,Wild type ,virus diseases ,food and beverages ,biochemical phenomena, metabolism, and nutrition ,Biology ,Microbiology ,Serine ,hemic and lymphatic diseases ,medicine ,Cultivar ,Agronomy and Crop Science ,Gene ,Pathogen - Abstract
We have previously identified genes for four different protease inhibitors (PIs) that were induced upon rice blast infection in a rice blast resistant mutant SHM-11. Our expression analysis of the PIs indicated that induction of the PIs was the highest 24 hr after rice blast inoculation in the rice mutant SHM-11. Three PIs in the group of serine PIs were highly expressed while a cystein PI was weakly expressed upon rice blast inoculation. Four PIs were weakly induced 48 hr after pathogen inoculation in rice blast susceptible wild type rice plant. The simultaneous expression of three serine PIs was apparent from SHM-11 and two of them were induced in rice blast resistant Taebaegbyeo. One of them was induced in rice blast resistant Hwayeongbyeo while none of them were expressed in rice blast susceptible Nagdongbyeo and rice blast resistant Dongjinbyeo. Our results suggest that the expression of PI gene is rice cultivar specific and may be linked with the rice blast resistance in a specific rice mutant by the simultaneous expression of the PI genes.
- Published
- 2005
23. Promoting Physical Fitness for Young Children
- Author
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Hyeon Chae Jeong and Myeong U Han
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Gerontology ,business.industry ,Physical fitness ,Psychology ,business - Published
- 2003
24. Growth and Maturation of a Green Alga, Caulerpa okamurae Weber van Bosse
- Author
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Jeong-U Han, Eun-Gyeong Hwang, Won-Jun Sin, Chang-Geun Choe, Cheol-Hyeon Son, and Chan-Seon Park
- Subjects
Caulerpa okamurae ,Ecology ,Botany ,Sampling (statistics) ,Plant Science ,Maturation process ,Aquatic Science ,Biology ,Ecology, Evolution, Behavior and Systematics ,Scuba diving - Abstract
Seasonal growth and maturation process of Caulerpa okamurae were investigated in natural populations and in culture. Monthly sampling was carried out by SCUBA diving at Baekunpo, Busan, southeastern coast of Korea from November 1999 to October 2001. Growth of erect branches depended mainly on the wa...
- Published
- 2003
25. Long-term evaluation of mice model infected with Helicobacter pylori : focus on gastric pathology including gastric cancer
- Author
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D. H. Kim, S. U. Han, Hee Jae Joo, S. W. Cho, T. Y. Oh, Y. J. Song, Jin Hong Kim, S. W. Kim, Ki Baik Hahm, D. Y. Kim, Yong Kwan Cho, Myung Wook Kim, and Y. B. Kim
- Subjects
Hepatology ,biology ,business.industry ,Stomach ,Spirillaceae ,Mucin ,Gastroenterology ,Cancer ,Helicobacter pylori ,medicine.disease ,biology.organism_classification ,medicine.anatomical_structure ,Dysplasia ,Immunology ,medicine ,Carcinoma ,Pharmacology (medical) ,Gastritis ,medicine.symptom ,business - Abstract
Background: Long-term evaluation of gastric pathology after H. pylori infection is very important in order to reveal its clinical implications, since debate still exists on the gastric carcinogenesis provoked by H. pylori infection in animal models. Aim: Either to evaluate the long-term outcome of H. pylori infection or to determine how H. pylori could provoke gastric cancer in the mice model. Methods: Four-week-old specific pathogen free C57BL/6 mice (n = 115) were infected with SS1. the mouse-adapted H. pylori strain. After 4, 8, 16, 24, 36, 50 and 80 weeks of bacterial infection, the H. pylori-infected mice were sacrificed. Results: After 80 weeks of infection, almost all the H. pylori-infected mice developed hyperplastic gastritis. but did not show any evidence of gastric adenoma, dysplasia or carcinoma. PCNA positive cells were most abundant after 50 weeks and tended to decrease thereafter up to 80 weeks, whereas apoptosis began to be noted 8 weeks after H. pylori infection, showing 7-8 apoptotic cells/high power field, and tending to increase as time passed. Normally observed neutral mucin decreased during the experiment, showing the most marked decrease 50 weeks after H. pylori infection. In contrast, acidic mucin was noted from 50 weeks after infection. Conclusion: The SS1-infected mouse seems to be a suitable animal model for H. pylori-related research. and H. pylori itself does not induce gastric cancer in normal wild-type mouse model following long-term exposure, which could be explained by the balance that exists between cell proliferation and apoptosis.
- Published
- 2003
26. The Stressors and Coping Strategies of University Fin Swimmers
- Author
-
Myeong U Han
- Subjects
Stressor ,Psychology ,Clinical psychology - Published
- 2003
27. Raman spectra of samarium–fullerene intercalation compounds
- Author
-
Yufang Wang, Hyon U. Han, Guoxiang Lan, and Xuewei Cao
- Subjects
Lanthanide ,Fullerene ,Intercalation (chemistry) ,Analytical chemistry ,chemistry.chemical_element ,General Chemistry ,Condensed Matter Physics ,Amorphous solid ,Carbide ,Samarium ,symbols.namesake ,chemistry ,Phase (matter) ,symbols ,General Materials Science ,Raman spectroscopy - Abstract
Samarium–fullerene intercalation compounds of nominal composition Sm x C 60 ( x =1,2,…,6) have been synthesized by a solid-state reaction method. We obtain a Sm 2.75 C 60 superconducting phase with orthogonal structure and a Sm 6 C 60 phase with body-centered cubic structure. The broadening and weakening of Raman peaks of the Sm x C 60 compounds are due to the distortion of C 60 and electron–phonon interaction. The Raman measurements reveal that the distortion of C 60 decrease in Sm x C 60 ( x =3,4,5) exposed to air, although the fulleride solids have transformed into an amorphous state. The Raman results also show that the distortion of C 60 is still very large in the Sm 6 C 60 exposed to air, or the C 60 molecules have been destroyed and become some amorphous carbide.
- Published
- 2002
28. Non-Contact Damage Detection of Rotating Shafts by Using the Magnetostrictive Effect
- Author
-
Ho-Cheol Lee, Sun-U Han, and Yun-Yeong Kim
- Subjects
Damage detection ,Engineering ,business.industry ,Mechanical Engineering ,Magnetostriction ,Structural engineering ,business - Published
- 2002
29. Treatment Characteristics of Rapid filtration Process treating Secondary Clarifier Effluent for Wastewater Reuse
- Author
-
Dong-U Han
- Subjects
Wastewater reuse ,law ,Scientific method ,Environmental science ,Pulp and paper industry ,Effluent ,Treatment characteristics ,Clarifier ,Filtration ,law.invention - Published
- 2002
30. Conditional loss of TGF-β signalling leads to increased susceptibility to gastrointestinal carcinogenesis in mice
- Author
-
Green J, Oh Ty, Y. B. Kim, Kim Sj, Kee Myung Lee, S. U. Han, Ahn Bo, Lee Mh, Ki Baik Hahm, Myung Wook Kim, Lee Wh, and Hong Ws
- Subjects
Gastrointestinal tract ,Hepatology ,Azoxymethane ,Kinase ,Gastroenterology ,Biology ,medicine.disease_cause ,chemistry.chemical_compound ,chemistry ,Downregulation and upregulation ,TGF beta signaling pathway ,Immunology ,medicine ,Cancer research ,Pharmacology (medical) ,Carcinogenesis ,Receptor ,Aberrant crypt foci - Abstract
Background: Downregulation of TGF-β receptors is implicated in colon cancer development. Inactivation of either of the two transmembrane serine/threonine kinases, TGF-β1 types I/II receptors, is now implicated in carcinogenesis, especially gastrointestinal carcinogenesis. Methods: We generated transgenic mice, called pS2–dnRII or ITF–dnRII, of which the dominant negative mutant of the TGF-β type II receptor was expressed under the control of tissue-specific promoters, the pS2 promoter for stomach and ITF for intestine. They were either infected with H.pylori (ATCC 43504 strain, CagA+ and VacA+) or administered with azoxymethane to determine the significance of loss of TGF-β signalling in gastrointestinal carcinogenesis. Results: Gastric adenocarcinoma developed in pS2–dnRII mice, whereas only chronic active gastritis was noted in wild-type littermates after 36 weeks of H.pylori infection. Mice lacking in TGF-β signalling specifically in the stomach showed a significantly higher proliferation cell nuclear antigen-labelling index when infected with H.pylori than wild-type littermates (P
- Published
- 2002
31. A proposal for blind signature scheme based on the elliptic curves suitable for wireless PKI
- Author
-
Jae-U Han, Jae-Cheol Ryu, Dae-Wan Han, and Lee-Jung Yun
- Subjects
Elliptic curve ,Theoretical computer science ,EdDSA ,Computer science ,Blind signature ,Elliptic Curve Digital Signature Algorithm ,ElGamal signature scheme ,Weil pairing ,Algorithm ,Computer Science::Databases ,Signature (logic) ,Schnorr signature - Abstract
In this paper we propose the efficient blind signature scheme based on Gap problem. We can find the short signature schemes for Weil pairing as the example of signature schemes based on Gap problem. Since short signature scheme is based on elliptic curve, our proposed signature scheme can be used in wireless PKI environment.
- Published
- 2002
32. Analysis of New Air Control System in Clean Stocker
- Author
-
Chang-U Han, Gi-Han Choe, and Sang-Ryong Lee
- Subjects
Engineering ,Mechanical vibration ,business.industry ,Filter (video) ,Mechanical Engineering ,Control system ,Airflow ,Electrical engineering ,Static pressure ,Work in process ,business ,Automotive engineering - Abstract
Clean stockers are being used by semiconductor and TFT-LCD manufacturers to store and buffer work in process. The only way to keep the stored product clean is to provide constant clean airflow the product and through stocker. Up to now, stockers typically have been configured to receive their laminar airflow from fan filter units that are located on the side of the stocker. This type of stocker may have such problems as complexity of structure, increment of temperature, mechanical vibration, initial investment and running cost. In this study, in order to solve the above mentioned problems, new air control system in stocker is proposed, which is to control open ratios of exits that are located on the side of the stocker without fan filter units. In this study, static pressure regain was used for the analysis of the open ratios of exits theoretically and experiment was also conducted using actual clean stocker for TFT-LCD manufacturers and CFDesign, was used for simulating airflow in stocker. As a result, open ratios of exits can be obtained by the analysis of static pressure regain and was verified by experiment and simulation results. Therefore, new air control system in stocker can be used by the semiconductor and TFT-LCD manufacturers.
- Published
- 2002
33. An Empirical Evaluation of Organizational Media Use in Singapore
- Author
-
Laku Chidambaram, Hock Chuan Chan, Kyung-U Han, and John Lim
- Subjects
Media management ,Matching (statistics) ,Information Systems and Management ,Portfolio ,Organizational communication ,Media relations ,Business ,Media richness theory ,Marketing ,Information Systems ,Variety (cybernetics) ,Task (project management) - Abstract
This paper reports on the organizational and individual determinants of media use in Singaporean organizations. While past research on media use has focused on matching a particular medium with a particular type of task, the current study proposes a "media coexistence" approach. This approach suggests that different media have, at the same time, both unique attributes (which allow them to exist as complements in a portfolio of choices) and similarities (which allow users to substitute one medium for another when needed). Data was collected using a survey from 151 respondents — comprised of managers and professionals — working in a variety of organizations located in Singapore. The results suggest that media use is multidimensional and not nearly as dichotomous as media richness theory suggests. For example, the same medium, telephones, can play a dual role depending on the circumstances: as a substitute for face-to-face communication and as a complement to other media such as e-mail or written com...
- Published
- 2001
34. A Study on Contact Resistance Failure Between Al-Ti-TiN Multi-Layer and W-Via Caused by Hillock Formation
- Author
-
S. J. Kim, Y. H. Kim, S. H. Kim, J. H. Kim, J. U. Han, S. J. Byun, and I. Chung
- Published
- 2013
35. A study of beta ratio improvement for solving the SRAM disturbance issue
- Author
-
S. J. Kim, J. U. Han, S. H. Kim, M. H. Hong, and I. Chung
- Subjects
Materials science ,Display driver ,business.industry ,Transistor ,Integrated circuit ,law.invention ,Ion ,law ,Electronic engineering ,Degradation (geology) ,Optoelectronics ,Undercut ,Static random-access memory ,Beta (finance) ,business - Abstract
We analyzed that how gate-poly-undercuts caused the disturbance failure in static random access memory (SRAM) bit-cells embedded in display driver integrated circuit (DDI) products. The beta ratio (ION of the pull-down transistor / ION of the pass-gate transistor) degradation induced by gate-poly undercuts was the main factor of the disturbance failure. Regarding the relation of undercuts and beta ratio, the hypothesis is as following: When the undercuts exist, dopants implanted with the halo process reach below the channel area more closely and it makes well concentration more high. Hence, the performance of the transistor (TR) with undercut becomes slower than normal TR. As the gate length of the pull-down (PD) TR is smaller than that of the pass-gate (PS) TR, the performance of the PD TR becomes more degraded than that of the PS TR. Consequently, the beta ratio decreases. To enhance beta ratio, we changed the thickness of photo-mask materials for the gate-poly layer and reduced the gate-poly etch time. Thanks to those actions, beta ratio was improved and we could completely overcome the disturbance failure issue.
- Published
- 2013
36. Genotypic Prevalence of the Adhesin Involved in Diffuse Adherence in Escherichia coli Isolates in Pre-weaned Pigs with Diarrhoea in Korea
- Author
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D. U. Han, S.-K. Ha, J. Kim, Y. Ha, S.-D. Lee, Chan Hee Chae, K. Jung, C. Choi, and S.-H. Kim
- Subjects
Diarrhea ,Genotype ,Swine ,Fimbria ,Virulence ,Enterotoxin ,medicine.disease_cause ,Polymerase Chain Reaction ,Virulence factor ,Microbiology ,law.invention ,law ,Escherichia coli ,Prevalence ,medicine ,Animals ,Escherichia coli Infections ,Polymerase chain reaction ,Swine Diseases ,Adhesins, Escherichia coli ,Korea ,biology ,Shiga toxin ,General Medicine ,Virology ,Bacterial adhesin ,Animals, Newborn ,biology.protein - Abstract
A total of 1002 Escherichia coli strains isolated from pre-weaned pigs with diarrhoea on 1114 swine farms were screened for the presence of the adhesin involved in diffuse adherence (AIDA) gene by polymerase chain reaction (PCR). Escherichia coli isolates that carried AIDA genes were also tested by PCR for the detection of five fimbriae (F4, F5, F6, F18 and F41), heat-stable (STa, STb) and heat-labile (LT) enterotoxin, enteroaggregative E. coli heat-stable enterotoxin 1 (EAST1), and Shiga toxin 2 oedema disease (Stx2e) genes. Twenty-three (2.3%) of the 1002 E. coli isolates carried the gene for AIDA. Among 23 isolates shown to carry genes for AIDA, three carried the AIDA gene as the only shown virulence factor. Other isolates carried other virulence factor genes in addition to AIDA. Four isolates carried genes for at least one of the fimbrial adhesins and enterotoxins. Sixteen isolates carried genes for enterotoxins only. The AIDA may represent an additional virulence determinant in pre-weaned pigs with diarrhoea.
- Published
- 2004
37. Anti-microbial Susceptibility for east1+Escherichia coli Isolated from Diarrheic Pigs in Korea
- Author
-
S.-K. Ha, D. U. Han, J. Kim, K. Jung, Chan Hee Chae, C. Choi, H.‐K. Chung, and W.-S. Cho
- Subjects
Diarrhea ,Veterinary medicine ,Swine ,Tetracycline ,Microbial Sensitivity Tests ,Weaning ,Biology ,medicine.disease_cause ,Microbiology ,Agar dilution ,Minimum inhibitory concentration ,Escherichia coli ,medicine ,Animals ,Escherichia coli Infections ,Volume concentration ,Swine Diseases ,Korea ,Drug Resistance, Microbial ,General Medicine ,Antimicrobial ,Anti-Bacterial Agents ,Colistin ,Ceftiofur ,medicine.drug - Abstract
The in vitro susceptibilities of 128 isolates of east1 + Escherichia coli from pre-weaned and post-weaned pigs with diarrhoea were tested with nine commonly used anti-microbial agents by an agar dilution minimal inhibitory concentration (MIC) procedure according to National Committee for Clinical Laboratory Standards guidelines. For the isolates from preweaned and post-weaned pigs, most of them were susceptible to low concentrations (MIC90) of tetracycline (4 and 2 microg/ml), ceftiofur (2 and 2 microg/ml), and colistin (4 and 2 microg/ml). Marked resistance was found in others.
- Published
- 2002
38. A new technique for inducing and releasing obstructive jaundice in rats
- Author
-
M.M. Özmen, M.T. Oruç, and U. Han
- Subjects
Male ,medicine.medical_specialty ,Kupffer Cells ,medicine.medical_treatment ,Rat model ,digestive system ,Gastroenterology ,Sham group ,Laparotomy ,Internal medicine ,medicine ,Animals ,Rats, Wistar ,Ligation ,Common Bile Duct ,Common bile duct ,business.industry ,Bilirubin ,Jaundice ,Alkaline Phosphatase ,digestive system diseases ,Rats ,Disease Models, Animal ,Jaundice, Obstructive ,surgical procedures, operative ,medicine.anatomical_structure ,Liver ,Surgery ,Obstructive jaundice ,medicine.symptom ,business ,Liver pathology - Abstract
Aim: It was the aim of this study to develop a simple, effective and reversible model of obstructive jaundice in rats. Material and Method: Totally, 24 rats were divided into 3 groups: the sham group including sham-operated control rats who underwent laparotomy only (n = 8), the common bile duct standard ligation technique (CBD-SL) group including rats with CBD ligation using silk (n = 8), and the CBD new ligation technique (CBD-NL) group consisting of rats with CBD ligation by a new technique (n = 8). After release of the ligations, the CBD-SL group continued as the CBD-SL releasing group, and the CBD-NL group as the CBD-NL releasing group. Results: It was observed that all the CBD ligated rats were both clinically and biochemically jaundiced but they were relieved after reversing the procedure. Conclusion: We present a simple, effective and reliable rat model which is suitable for studies which require a reversal of obstructive jaundice in rats.
- Published
- 2009
39. Effect of erythropoietin on oxidative stress and liver injury in experimental obstructive jaundice
- Author
-
U. Han, Mehmet Tahir Oruç, E. Dilektasli, E. Dikicier, M. Moran, H.T. Besler, and M. Mahir Ozmen
- Subjects
Male ,medicine.medical_specialty ,medicine.disease_cause ,Nitric Oxide ,Nitric oxide ,chemistry.chemical_compound ,hemic and lymphatic diseases ,Internal medicine ,Malondialdehyde ,Medicine ,Animals ,Rats, Wistar ,Erythropoietin ,Liver injury ,business.industry ,Bilirubin ,Glutathione ,Jaundice ,medicine.disease ,Alkaline Phosphatase ,Pathophysiology ,Recombinant Proteins ,Rats ,Disease Models, Animal ,Jaundice, Obstructive ,Oxidative Stress ,Endocrinology ,chemistry ,Liver ,Surgery ,medicine.symptom ,business ,Oxidative stress ,medicine.drug - Abstract
Background: To evaluate the time-dependent effects and pathophysiological mechanism of erythropoietin (Epo) on oxidative stress and liver injury resulting from obstructive jaundice in common bile duct-ligated rats. Methods: Wistar Albino rats were divided into 5 groups, each including 8 rats. The sham group underwent laparotomy only, while the Non-Epo-3 and Non-Epo-7 groups underwent common bile duct ligation and were sacrificed 3 and 7 days, respectively, after the operation. The Epo-3 and Epo-7 groups underwent common bile duct ligation and Epo treatment and were sacrificed 3 and 7 days, respectively, after the operation. Blood and tissue samples were collected from all groups for the determination of oxidative injury and hepatocellular damage. Serum total and direct bilirubin levels, alkaline phosphatase, reduced glutathione (GSH), nitric oxide (NO), malondialdehyde (MDA) and white blood cell counts were measured. Results: Significantly higher NO and MDA levels were found in Non-Epo groups than Epo groups. Significantly lower GSH levels were found in the Non-Epo-7 group than the Epo-7 and sham groups. Hepatocellular damage was also found to be reduced in Epo groups. Conclusions: In the present model, while common bile duct ligation increased oxidative injury and hepatocellular damage, treatment with Epo attenuated oxidative injury and hepatocellular damage by decreasing NO and increasing GSH.
- Published
- 2008
40. W-plasty technique in tracheal reconstruction: a new technique? An experimental study
- Author
-
S, Han, U, Han, C, Atinkaya, T, Cavusoglu, G, Osmanoglu, and E, Dikmen
- Subjects
Male ,Trachea ,Anastomosis, Surgical ,Suture Techniques ,Animals ,Rabbits ,Plastic Surgery Procedures - Abstract
Tracheal stenosis and dehiscence of anastomosis due to excessive tension are well-known problems after long-segment tracheal resections. The aim of this study was to evaluate the efficacy of the W-plasty technique to prevent these two complications.Animals were divided into a study and a control group. Each group consisted of 6 animals. In the control group, we performed a 5-cm tracheal segment resection, and then reconstruction was performed with an interrupted technique with 6/0 Prolene sutures. In the study group, we used the W-plasty technique with 6/0 Prolene interrupted sutures. The animals were sacrificed on the 30th day postoperatively and tracheal resection including the entire anastomosis site was performed. The traction and pullout test was applied to each specimen and all the specimens were analysed histopathologically. The intraluminal diameter and the thickness of the tracheal wall at the level of anastomoses were measured by using a micrometer. The pattern of the reaction and localization were recorded.The traction and pullout test results were 131.6 +/- 4.3 g and 187.5 +/- 6.4 g in the control and the study group, respectively, which was a significant difference (p = 0.004). The intraluminal diameters were 3.3 +/- 1.2 mm and 4.3 +/- 0.9 mm in the control and study group, respectively (p = 0.134). In contrast to the control group, early inflammatory and late fibroblastic reactions were negative in the study group.Considering the outcomes of this study, we think that the W-plasty technique has much more advantages than the standard techniques in terms of anastomosis durability and development of stenosis.
- Published
- 2008
41. Expressions of p53, VEGF C, p21: could they be used in preoperative evaluation of lymph node metastasis of esophageal squamous cell carcinoma?
- Author
-
B. Kayhan, B. U. Onal, O. I. Can, U. Han, and S. Han
- Subjects
squamous cell carcinoma ,p53 ,Cyclin-Dependent Kinase Inhibitor p21 ,Male ,Pathology ,medicine.medical_specialty ,Esophageal Neoplasms ,Pathological staging ,Biopsy ,Vascular Endothelial Growth Factor C ,Sensitivity and Specificity ,Antibodies ,Esophagus ,Predictive Value of Tests ,Preoperative Care ,Carcinoma ,medicine ,Humans ,Stage (cooking) ,Retrospective Studies ,lymph node metastasis ,p21 ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,General Medicine ,medicine.disease ,Genes, p53 ,Immunohistochemistry ,medicine.anatomical_structure ,Vascular endothelial growth factor C ,Lymphatic Metastasis ,Carcinoma, Squamous Cell ,Female ,Lymph ,business ,VEGF C - Abstract
WOS: 000248997700003 PubMed: 17760650 The prognosis of esophageal squamous cell carcinoma is primarily determined by staging. Although radiological methods have revealed lymph node metastasis preoperatively, these radiological findings cannot be correlated with pathological staging. The aim of this study was to compare the expressions of p53, vascular endothelial growth factor C (VEGF C) and p21 with lymph node metastasis in preoperative endoscopic biopsy and postoperative resection material. Tissue samples were taken from 40 patients who had undergone endoscopic biopsies and radical esophagectomies. The expressions of p53, VEGF C and p21 proteins in these sections were immunohistochemically examined. The expression of each antibody was characterized as a negative or positive reaction according to the pattern and intensity of semiquantitative immunostaining. The staining pattern of antibodies was divided into three groups: < 10% cancer cells were accepted to be (-), 10-50% were (+), heterogenous and > 50% were (+ +), homogenous. For each antibody, statistical correlation with conventional prognostic parameters such as localization, microscopic grade, stage, pathological lymph node metastasis and survival, were investigated. p53 expression was observed in 65.5% (19/29) of lymph node positive cases, whereas p53 was in 50% (20/40) of cases. VEGF C was in 65% (26/40) and p21 was in 15% (6/40) of cases. p53 has the specificity of 90.9% and sensitivity rate of 65.5% in detecting lymph node metastasis and positive predictive value was 95%. Expression of p53 was significantly correlated with stage and lymph node metastasis (P = 0.02 and P = 0.03, respectively). Prediction of lymph node metastasis by p53 was correlated independently and in coexpression with VEGF C (P < 0.01). There was no relation detected between p21 and other parameters. In esophageal squamous cell carcinoma (SCC), p53 and VEGF C expressions were correlated with pathologically positive lymph nodes. When preoperative staging has been insufficient in esophageal carcinoma cases, immunohistochemical analysis of p53 and VEGF C staining in tissues could be an aid to clinicians regarding lymph node metastasis.
- Published
- 2007
42. Identification of rice genes induced in a rice blast-resistant mutant
- Author
-
Chong U, Han, Chan Hui, Lee, Kyoung Soo, Jang, Gyung Ja, Choi, He Kyoung, Lim, Jin-Cheol, Kim, Sang-Nag, Ahn, Jae Eul, Choi, Jae Soon, Cha, Heung Tae, Kim, Kwang Yun, Cho, and Seon-Woo, Lee
- Subjects
Magnaporthe ,DNA, Complementary ,Arabidopsis Proteins ,Gene Expression Regulation, Plant ,Peptide Initiation Factors ,Gene Expression Profiling ,Mutation ,RNA-Binding Proteins ,Oryza ,Receptors, Cell Surface ,Protein Serine-Threonine Kinases ,Genes, Plant ,Plant Proteins - Abstract
To clarify mechanisms of rice blast resistance in rice plants we used suppression subtractive hybridization (SSH) to isolate genes induced upon rice blast inoculation in a rice blast-resistant mutant. A total of 26 rice cDNAs were isolated and found to have elevated expression upon rice blast infection in a rice blast-resistant derivative, SHM-11, of the rice cultivar, Sanghaehyanghyella. Sequencing of the cDNAs revealed that many of the proteins they encoded had been previously described as involved in plant responses against pathogen attack. Two interesting groups of the defense-related proteins consisted of three different PR5 homologues and four different protease inhibitors, all highly expressed in the rice blast mutant. Genes encoding proteins involved in signal transduction and regulation were also identified, including translation initiation factor eIF5A, C2 domain DNA binding protein, putative rice EDS and putative receptor like kinase. Most of the identified cDNAs were highly expressed 24 h after blast inoculation. Our results suggest that a pathway regulating defense gene expression may be altered in the mutant, resulting in early induction of the defense genes upon fungal infection.
- Published
- 2004
43. Antiviral effect of Saccharomyces cerevisiae beta-glucan to swine influenza virus by increased production of interferon-gamma and nitric oxide
- Author
-
W. K. Moon, S.-K. Ha, Chan Hee Chae, D.-W. Kim, K. Jung, D. U. Han, and Y. Ha
- Subjects
Swine ,animal diseases ,Administration, Oral ,Saccharomyces cerevisiae ,Biology ,medicine.disease_cause ,Nitric Oxide ,Antiviral Agents ,Virus ,Nitric oxide ,Microbiology ,chemistry.chemical_compound ,Tissue culture ,Interferon-gamma ,Orthomyxoviridae Infections ,Influenza A virus ,medicine ,Animals ,Interferon gamma ,Glucans ,Lung ,Swine Diseases ,Vaccines ,medicine.diagnostic_test ,virus diseases ,General Medicine ,Virology ,Bronchoalveolar lavage ,medicine.anatomical_structure ,chemistry ,Viral replication ,Animals, Newborn ,medicine.drug - Abstract
The aim of these experiments was to investigate the potential antiviral effect of Saccharomyces cerevisiae beta-glucan on the pneumonia induced by swine influenza virus (SIV). Forty colostrum-deprived 5-day-old piglets were randomly divided into four groups of 10. The 20 pigs in groups 1 and 2 were administered Saccharomyces cerevisiae beta-glucan orally (50 mg/day/pig; En-Bio Technology Co., Ltd) for 3 days before SIV infection and those in groups 3 and 4 were given culture medium/diluent alone. Groups 1 and 3 were inoculated intranasally with 3 ml of tissue culture fluid containing 2 x 10(6) tissue culture infective doses 50% (TCID(50))/ml of SIV and those in groups 2 and 4 were exposed in the same manner to uninfected cell culture supernatant. The microscopic lung lesions induced by SIV infection (group 1 pigs) were significantly more severe than those induced by infection in animals pre-administered beta-glucan (group 3) (P < 0.05). Significantly more SIV nucleic acid was detected in the lungs of pigs experimentally infected with SIV only (group 1) at 5, 7 and 10 days post-inoculation (dpi) compared with lungs from pigs pre-administered beta-glucan and infected with SIV (group 3) (P < 0.05). The concentrations of interferon-gamma (IFN-gamma) and nitric oxide (NO) in bronchoalveolar lavage fluid from pigs pre-administered beta-glucan and infected with SIV (group 3) were significantly higher than for any other group at 7 and 10 dpi for IFN-gamma, and at 5, 7 and 10 dpi for NO (P < 0.05). Saccharomyces cerevisiae beta-glucan reduced the pulmonary lesion score and viral replication rate in SIV-infected pigs. These findings support the potential application of beta-glucan as prophylactic/treatment agent in influenza virus infection.
- Published
- 2004
44. Conditional loss of TGF-beta signalling leads to increased susceptibility to gastrointestinal carcinogenesis in mice
- Author
-
K-B, Hahm, K M, Lee, Y B, Kim, W S, Hong, W H, Lee, S U, Han, M W, Kim, B O, Ahn, T Y, Oh, M H, Lee, J, Green, and S J, Kim
- Subjects
Helicobacter pylori ,Carcinoma ,Azoxymethane ,Mice, Transgenic ,Helicobacter Infections ,Mice ,Stomach Neoplasms ,Transforming Growth Factor beta ,Gastritis ,Colonic Neoplasms ,Carcinogens ,Animals ,Disease Susceptibility ,Receptors, Transforming Growth Factor beta ,Signal Transduction - Abstract
Downregulation of TGF-beta receptors is implicated in colon cancer development. Inactivation of either of the two transmembrane serine/threonine kinases, TGF-beta1 types I/II receptors, is now implicated in carcinogenesis, especially gastrointestinal carcinogenesis.We generated transgenic mice, called pS2-dnRII or ITF-dnRII, of which the dominant negative mutant of the TGF-beta type II receptor was expressed under the control of tissue-specific promoters, the pS2 promoter for stomach and ITF for intestine. They were either infected with H.pylori (ATCC 43504 strain, CagA+ and VacA+) or administered with azoxymethane to determine the significance of loss of TGF-beta signalling in gastrointestinal carcinogenesis.Gastric adenocarcinoma developed in pS2-dnRII mice, whereas only chronic active gastritis was noted in wild-type littermates after 36 weeks of H.pylori infection. Mice lacking in TGF-beta signalling specifically in the stomach showed a significantly higher proliferation cell nuclear antigen-labelling index when infected with H.pylori than wild-type littermates (P0.01). Development of colonic aberrant crypt foci was provoked in mice by intraperitoneal injections of azoxymethane, and ITF-dnRII mice showed significantly higher incidences of ACF and colon cancers than wild-type littermates.Maintaining normal TGF-beta signalling in the gastrointestinal tract seems to be important either for preventing abnormal mucosal proliferation, or for suppressing or retarding carcinogenesis.
- Published
- 2002
45. Prevalence of Brachyspira pilosicoli in Korean pigs, determined using a nested PCR
- Author
-
W-S. Cho, Changsun Choi, H-K. Chung, J. Kim, B. S. Yoon, Chan Hee Chae, D. U. Han, and T. Jung
- Subjects
Swine Diseases ,Korea ,General Veterinary ,biology ,Swine ,Brachyspira pilosicoli ,Spirochaeta ,General Medicine ,Spirochaetales Infections ,biology.organism_classification ,Virology ,Polymerase Chain Reaction ,Prevalence ,Animals ,Nested polymerase chain reaction - Published
- 2002
46. On giant shoulders: how a seamount affects the microbial community composition of seawater and sponges
- Author
-
K. Busch, U. Hanz, F. Mienis, B. Mueller, A. Franke, E. M. Roberts, H. T. Rapp, and U. Hentschel
- Subjects
Ecology ,QH540-549.5 ,Life ,QH501-531 ,Geology ,QE1-996.5 - Abstract
Seamounts represent ideal systems to study the influence and interdependency of environmental gradients at a single geographic location. These topographic features represent a prominent habitat for various forms of life, including microbiota and macrobiota, spanning benthic as well as pelagic organisms. While it is known that seamounts are globally abundant structures, it still remains unclear how and to which extent the complexity of the sea floor is intertwined with the local oceanographic mosaic, biogeochemistry, and microbiology of a seamount ecosystem. Along these lines, the present study aimed to explore whether and to what extent seamounts can have an imprint on the microbial community composition of seawater and of sessile benthic invertebrates, sponges. For our high-resolution sampling approach of microbial diversity (16S rRNA gene amplicon sequencing) along with measurements of inorganic nutrients and other biogeochemical parameters, we focused on the Schulz Bank seamount ecosystem, a sponge ground ecosystem which is located on the Arctic Mid-Ocean Ridge. Seawater samples were collected at two sampling depths (mid-water, MW, and near-bed water, BW) from a total of 19 sampling sites. With a clustering approach we defined microbial microhabitats within the pelagic realm at Schulz Bank, which were mapped onto the seamount's topography and related to various environmental parameters (such as suspended particulate matter, SPM; dissolved inorganic carbon, DIC; silicate, SiO4-; phosphate, PO43-; ammonia, NH4+; nitrate, NO32-; nitrite, NO2-; depth; and dissolved oxygen, O2). The results of our study reveal a “seamount effect” (sensu stricto) on the microbial mid-water pelagic community at least 200 m above the sea floor. Further, we observed a strong spatial heterogeneity in the pelagic microbial landscape across the seamount, with planktonic microbial communities reflecting oscillatory and circulatory water movements, as well as processes of bentho-pelagic coupling. Depth, NO32-, SiO4-, and O2 concentrations differed significantly between the determined pelagic microbial clusters close to the sea floor (BW), suggesting that these parameters were presumably linked to changes in microbial community structures. Secondly, we assessed the associated microbial community compositions of three sponge species along a depth gradient of the seamount. While sponge-associated microbial communities were found to be mainly species-specific, we also detected significant intra-specific differences between individuals, depending on the pelagic near-bed cluster they originated from. The variable microbial phyla (i.e. phyla which showed significant differences across varying depth, NO32-, SiO4-, O2 concentrations, and different from local seawater communities) were distinct for every sponge species when considering average abundances per species. Variable microbial phyla included representatives of both those taxa traditionally counted for the variable community fraction and taxa counted traditionally for the core community fraction. Microbial co-occurrence patterns for the three examined sponge species Geodia hentscheli, Lissodendoryx complicata, and Schaudinnia rosea were distinct from each other. Over all, this study shows that topographic structures such as the Schulz Bank seamount can have an imprint (seamount effect sensu lato) on both the microbial community composition of seawater and sessile benthic invertebrates such as sponges by an interplay between the geology, physical oceanography, biogeochemistry, and microbiology of seamounts.
- Published
- 2020
- Full Text
- View/download PDF
47. Ultrasonography and MRI findings of cutaneous B-cell lymphoma, leg type
- Author
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Alper Dilli, Baki Hekimoglu, Emine Öztürk, S Sipahioglu, Cüneyt Yücesoy, and U Han
- Subjects
lcsh:Medical physics. Medical radiology. Nuclear medicine ,Pathology ,medicine.medical_specialty ,Fatal outcome ,medicine.diagnostic_test ,business.industry ,lcsh:R895-920 ,Cutaneous B-cell lymphoma ,Cancer ,Magnetic resonance imaging ,Leg type ,medicine.disease ,Lymphoma ,hemic and lymphatic diseases ,Medicine ,Ultrasonography ,business ,Mri findings - Abstract
We read the case report about imaging findings of cutaneous B-cell lymphoma in JBR-BTR with great interest (1). We would like to share ultrasonographic and magnetic resonance imaging (MRI) findings of our case with primary cutaneous B-cell lymphoma, leg type.
- Published
- 2011
48. Detection of Respiratory Viruses and Atypical Bacterial Pathogens in Infants with Acute Respiratory Infections Using Multiplex PCR
- Author
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Bo Moon Shin, Jeong U Han, and Soo Jin Yoo
- Subjects
Mycoplasma pneumoniae ,Bordetella pertussis ,Atypical bacteria ,biology ,business.industry ,viruses ,Respiratory infection ,General Medicine ,respiratory system ,medicine.disease_cause ,biology.organism_classification ,Virology ,Virus ,respiratory tract diseases ,Microbiology ,Human metapneumovirus ,Multiplex polymerase chain reaction ,medicine ,Rhinovirus ,business - Abstract
Multiplex PCR of nasopharyngeal aspirates detected viruses and atypical bacteria in 75.3% (219/291) of infants with acute respiratory infections from July 2010 to June 2013. Frequent viruses were human rhinovirus (29.9%), parainfluenza virus (21.7%), respiratory syncytial virus (17.9%), and human metapneumovirus (10.3%). Mycoplasma pneumoniae and Bordetella pertussis were detected in 3.4% and 0.3%, respectively. (Ann Clin Microbiol 2014;17:86-90)
- Published
- 2014
49. Methylation of O(6)-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma
- Author
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T J, Park, S U, Han, Y K, Cho, W K, Paik, Y B, Kim, and I K, Lim
- Subjects
Adult ,Aged, 80 and over ,Male ,Carcinogenicity Tests ,Adenocarcinoma ,DNA Methylation ,Middle Aged ,Disease-Free Survival ,O(6)-Methylguanine-DNA Methyltransferase ,Genes, ras ,Stomach Neoplasms ,Lymphatic Metastasis ,Mutation ,Humans ,Female ,Promoter Regions, Genetic ,Aged ,Neoplasm Staging - Abstract
O(6)-methylguanine-DNA methyltransferase (MGMT) can remove O(6)alkylG DNA adducts. If they are not removed, then the adducts mispair with T during DNA replication, resulting in G-to-A mutation. Interrelations between MGMT gene inactivation by promoter methylation, K-ras mutation, and clinicopathologic features in patients with gastric carcinoma were studied.Surgically removed tumor tissues from 79 patients were analyzed with MGMT methylation by genomic DNA modification and methylation specific polymerase chain reaction analysis, K-ras mutation by mutant allele specific amplification, TNM classification according to the International Union Against Cancer system, and MGMT protein expression by immunohistochemistry.MGMT-promoter methylation was found in 18 of 79 tumors. Among those 18 tumors, K-ras mutations were found in 33% and 11% of tumors at codons 12 and 13, respectively, corresponding to 20 times and 7 times greater rates of mutation compared with unmethylated tumors. MGMT methylation was associated significantly with lymph node invasion (P0.01), tumor stage (P0.03) and 5-year disease free survival (P0.02). MGMT protein expression was detected in intestinal metaplasia and adenocarcinoma samples, whereas no expression was detected in normal foveolar cells.MGMT-promoter methylation in patients with gastric carcinoma was associated significantly with point mutations of K-ras at codons 12 and 13, lymph node invasion, tumor stage, and disease free survival. These associations indicate a significant role of MGMT methylation during gastric carcinogenesis.
- Published
- 2001
50. Simultaneous detection of porcine circovirus type 2 and porcine parvovirus in pigs with PMWS by multiplex PCR
- Author
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J. Kim, D. U. Han, C. Choi, and C. Chae
- Subjects
Circovirus ,Swine Diseases ,Porcine parvovirus ,General Veterinary ,Swine ,Wasting Syndrome ,General Medicine ,Biology ,Parvovirus, Porcine ,biology.organism_classification ,Virology ,Polymerase Chain Reaction ,Parvoviridae Infections ,Porcine circovirus ,Multiplex polymerase chain reaction ,DNA, Viral ,Animals ,Lymph Nodes - Published
- 2001
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