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333 results on '"Thorns, Christoph"'

1. Localized pigmented villo-nodular synovitis of trochanteric bursa

Author

Bruns, Juergen, Rosenbaum, Benedikt, and Thorns, Christoph

Subjects
pigmented villo-nodular synovitis, pvns, tenosynovial giant cell tumors, tsgct, circumscribed, diffuse, bursa, bursa trochanterica, Surgery, RD1-811
Abstract

This is the first report on a localized pigmented villo-nodular synovitis (PVNS or TSGCT) occurring in the trochanteric bursa. Bursal involvement in PVNS is extremely rare. Most often PVNS occurs either as a localized or diffuse lesion in a major synovial joint, such as the knee, ankle joint or hip joint. In principle, all synovial structures can be involved. The case reported here is remarkable regarding the long period between the occurrence of the first symptoms and the final diagnosis as well as the age of the female patient (75 yrs).Therapeutically a complete resection was performed in order to avoid recurrence. More then three years later the patient did well and there has been no evidence of recurrence yet.

Published
2023
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3. Gene expression-based outcome prediction in advanced stage classical Hodgkin lymphoma treated with BEACOPP

Author

Jachimowicz, Ron D., Klapper, Wolfram, Glehr, Gunther, Müller, Horst, Haverkamp, Heinz, Thorns, Christoph, Hansmann, Martin Leo, Möller, Peter, Stein, Harald, Rehberg, Thorsten, von Tresckow, Bastian, Reinhardt, H. C., Borchmann, Peter, Chan, Fong Chun, Spang, Rainer, Scott, David W., Engert, Andreas, Steidl, Christian, Altenbuchinger, Michael, and Rosenwald, Andreas

Published
2021
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5. Prospective postmortem evaluation of 735 consecutive SARS-CoV-2-associated death cases

Author

Fitzek, Antonia, Schädler, Julia, Dietz, Eric, Ron, Alexandra, Gerling, Moritz, Kammal, Anna L., Lohner, Larissa, Falck, Carla, Möbius, Dustin, Goebels, Hanna, Gerberding, Anna-Lina, Schröder, Ann Sophie, Sperhake, Jan-Peter, Klein, Anke, Fröb, Daniela, Mushumba, Herbert, Wilmes, Sandra, Anders, Sven, Kniep, Inga, Heinrich, Fabian, Langenwalder, Felicia, Meißner, Kira, Lange, Philine, Zapf, Antonia, Püschel, Klaus, Heinemann, Axel, Glatzel, Markus, Matschke, Jakob, Aepfelbacher, Martin, Lütgehetmann, Marc, Steurer, Stefan, Thorns, Christoph, Edler, Carolin, and Ondruschka, Benjamin

Published
2021
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9. Molecular characteristics of diffuse large B-cell lymphoma in the Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin lymphomas (PETAL) trial: correlation with interim PET and outcome

Author

Richter, Julia, Hüttmann, Andreas, Rekowski, Jan, Schmitz, Christine, Gärtner, Selina, Rosenwald, Andreas, Hansmann, Martin-Leo, Hartmann, Sylvia, Möller, Peter, Wacker, Hans-Heinrich, Feller, Alfred, Thorns, Christoph, Müller, Stefan, Dührsen, Ulrich, and Klapper, Wolfram

Published
2019
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11. Single-Cell Genetic Analysis Reveals Insights into Clonal Development of Prostate Cancers and Indicates Loss of PTEN as a Marker of Poor Prognosis

Author

Heselmeyer-Haddad, Kerstin M., Berroa Garcia, Lissa Y., Bradley, Amanda, Hernandez, Leanora, Hu, Yue, Habermann, Jens K., Dumke, Christoph, Thorns, Christoph, Perner, Sven, Pestova, Ekaterina, Burke, Catherine, Chowdhury, Salim A., Schwartz, Russell, Schäffer, Alejandro A., Paris, Pamela L., and Ried, Thomas

Published
2014
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18. Prognostic significance of immunohistochemical biomarkers in diffuse large B-cell lymphoma: a study from the Lunenburg Lymphoma Biomarker Consortium

Author

Salles, Gilles, de Jong, Daphne, Xie, Wanling, Rosenwald, Andreas, Chhanabhai, Mukesh, Gaulard, Philippe, Klapper, Wolfram, Calaminici, Maria, Sander, Birgitta, Thorns, Christoph, Campo, Elias, Molina, Thierry, Lee, Abigail, Pfreundschuh, Michael, Horning, Sandra, Lister, Andrew, Sehn, Laurie H., Raemaekers, John, Hagenbeek, Anton, Gascoyne, Randy D., and Weller, Edie

Published
2011
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21. Immunoblastic morphology but not the immunohistochemical GCB/nonGCB classifier predicts outcome in diffuse large B-cell lymphoma in the RICOVER-60 trial of the DSHNHL

Author

Ott, German, Ziepert, Marita, Klapper, Wolfram, Horn, Heike, Szczepanowski, Monika, Bernd, Heinz-Wolfram, Thorns, Christoph, Feller, Alfred C., Lenze, Dido, Hummel, Michael, Stein, Harald, Müller-Hermelink, Hans-Konrad, Frank, Matthias, Hansmann, Martin-Leo, Barth, Thomas F.E., Möller, Peter, Cogliatti, Sergio, Pfreundschuh, Michael, Schmitz, Norbert, Trümper, Lorenz, Loeffler, Markus, and Rosenwald, Andreas

Published
2010
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29. The “North German Tumor Bank of Colorectal Cancer”: status report after the first 2 years of support by the German Cancer Aid Foundation

Author

Oberländer, Martina, Linnebacher, Michael, König, Alexandra, Bogoevska, Valentina, Brodersen, Christiane, Kaatz, Regina, Krohn, Mathias, Hackmann, Michael, Ingenerf, Josef, Christoph, Jan, Mate, Sebastian, Prokosch, Hans-Ulrich, Yekebas, Emre F., Thorns, Christoph, Büning, Jürgen, Prall, Friedrich, Uhlig, Ria, Roblick, Uwe J., Izbicki, Jakob R., Klar, Ernst, Bruch, Hans-Peter, Vollmar, Brigitte, Habermann, Jens K., and On behalf of the ColoNet consortium

Published
2013
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30. Single Cell Genetic Profiling of Tumors of Breast Cancer Patients Aged 50 Years and Older Reveals Enormous Intratumor Heterogeneity Independent of Individual Prognosis

Author

Liegmann, Anna-Sophie, primary, Heselmeyer-Haddad, Kerstin, additional, Lischka, Annette, additional, Hirsch, Daniela, additional, Chen, Wei-Dong, additional, Torres, Irianna, additional, Gemoll, Timo, additional, Rody, Achim, additional, Thorns, Christoph, additional, Gertz, Edward Michael, additional, Alkemade, Hendrik, additional, Hu, Yue, additional, Habermann, Jens K., additional, and Ried, Thomas, additional

Published
2021
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31. Whole-slide image analysis of the tumor as a predictor of adverse outcome in patients with advanced-stage classical Hodgkin lymphoma treated with BEACOPP

Author

Jachimowicz, Ron Daniel, Pieper, Luise, Reinke, Sarah, Gontarewicz, Artur, Pluetschow, Annette, Haverkamp, Heinz, Frauenfeld, Leonie, Fend, Falko, Overkamp, Mathis, Jochims, Franziska, Thorns, Christoph, Hansmann, Martin Leo, Moller, Peter, Rosenwald, Andreas, Stein, Harald, Reinhardt, Hans Christian, Borchmann, Peter, von Tresckow, Bastian, Engert, Andreas, Klapper, Wolfram, Jachimowicz, Ron Daniel, Pieper, Luise, Reinke, Sarah, Gontarewicz, Artur, Pluetschow, Annette, Haverkamp, Heinz, Frauenfeld, Leonie, Fend, Falko, Overkamp, Mathis, Jochims, Franziska, Thorns, Christoph, Hansmann, Martin Leo, Moller, Peter, Rosenwald, Andreas, Stein, Harald, Reinhardt, Hans Christian, Borchmann, Peter, von Tresckow, Bastian, Engert, Andreas, and Klapper, Wolfram

Abstract

A subset of patients with advanced-stage classical Hodgkin lymphoma (cHL) relapse or progress following standard treatment. Given their dismal prognosis, identifying this group of patients upfront represents an important medical need. While prior research has identified characteristics of the tumor microenvironment, which are associated with cHL outcomes, biomarkers that are developed and validated in this high-risk group are still lacking. Here, we applied whole-slide image analysis (WSI), a quantitative, large-scale assessment of tumor composition that utilizes conventional histopathology slides. We conducted WSI on pre-treatment biopsies from 340 patients with advanced-stage cHL enrolled in the HD12 and HD15 trials of the German Hodgkin Study Group (GHSG), and tested our results in a validation cohort of 147 advanced-stage cHL patients within the GHSG HD18 trial. All patients were treated with BEACOPP-based regimens. By quantifying T cells, B cells, Hodgkin and Reed-Sternberg cells and macrophages with WSI, 80% of all cells in the tumor tissue were identified. Crucially, low B-cell count was associated with significantly reduced progression-free survival and overall survival, while the content of T cells, macrophages and Hodgkin and Reed-Sternberg cells was not associated with the risk of progression or relapse in the study cohort. We further validated low B-cell content as a prognostic factor for progression-free survival and overall survival in the validation cohort and demonstrated the good inter-observer agreement of WSI. WSI may represent a key tool for risk stratification of advanced-stage cHL and can easily be added to the standard diagnostic histopathology work-up.

Published
2021

38. Tumor budding as a prognostic factor in pancreatic ductal adenocarcinoma

Author

Petrova, Ekaterina, primary, Zielinski, Verena, additional, Bolm, Louisa, additional, Schreiber, Cleopatra, additional, Knief, Juliana, additional, Thorns, Christoph, additional, Bronsert, Peter, additional, Timme-Bronsert, Sylvia, additional, Bausch, Dirk, additional, Perner, Sven, additional, Keck, Tobias, additional, and Wellner, Ulrich, additional

Published
2019
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40. Additional file 1: of Spatial UBE2N protein expression indicates genomic instability in colorectal cancers

Author

Gemoll, Timo, Miroll, Elena, Klein, Oliver, Lischka, Annette, Eravci, Murat, Thorns, Christoph, and Habermann, Jens

Abstract

Figure S1. MALDI imaging intensity box plots of identified peptides for UBE2N (m/z 1043.635 & m/z 1203.593; top) and SPTBN1 (m/z 959.513 & m/z 1203.593 bottom). Intensity plots of the two identified peptides UBE2N and SPTBN1 detected differentially regulated by MALDI imaging. Figure S2. Tissue-microarray-based immunohistochemical evaluation of UBE2N by means of image scope comparing normal mucosa vs. CRC and euploid vs. aneuploid CRCs after combining data of the training and validation TMA set. Bar plots and ROC curve of immunhistochemical data of UBE2N after combining data of the training and validation TMA set. Figure S3. Exemplary immunohistochemical UBE2N stainings of the TMA validation set. Images are presented as an overview (A) as well as an image section (B). Overview of exemplary immuohistochemical images of UBE2N. The images present results from the TMA validation set. Figure S4. Tissue-microarray-based immunohistochemical evaluation of SPTBN1 by means of image scope comparing normal mucosa vs. CRC and euploid vs. aneuploid CRCs in the training and validation set. Bar plots of immunhistochemical data of SPTBN1. The images present results from the TMA validation set. (DOCX 21654 kb)

Published
2019
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41. Density of CD8-positive tumor-infiltrating T-lymphocytes is an independent prognostic factor in adenocarcinoma of the esophagogastric junction

Author

Knief, Juliana, Lazar Karsten, Pamela, Wellner, Ulrich, Humme, Richard, and Thorns, Christoph

Subjects
Esophagogastric junctio, 6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología [CDU], CD103, CD8, Adenocarcinoma, Tumor-infiltrating lymphocytes
Abstract

Tumor-infiltrating lymphocytes (TILs) have commonly been associated with markedly improved prognosis in a variety of human cancers, including carcinomas of the upper and lower gastrointestinal tract. Especially the presence of T-cells (cytotoxic as well as helper cells) seems to define a subgroup of patients with prolonged overall and event-free survival. The density of TILs was assessed via immunohistochemistry for CD8 and CD103 in a population of 228 adenocarcinomas of the esophagogastric junction. Density of CD8+ Tlymphocytes was inversely correlated with depth of tumor infiltration (p=0.013) while no correlation with any of the analyzed clinicopathologic factors could be established for CD103-density. High density of CD8- positive T-cells additionally showed significantly longer overall survival (OS) with a p-value of 0.024 while density of CD103+ cells was associated with prolonged tumor free survival (p-value 0.011). Independence could be demonstrated applying Cox proportional hazard analysis (Hazard Ratio 0.742; 95%-Confidence Interval 0.579-0.951; p=0.019). High density of CD8-positive Tlymphocytes identifies a patient subgroup with significantly prolonged overall survival, is correlated with tumor stage and might open up new therapeutic possibilities via immunomodulating drugs.

Published
2019

42. MALDI-imaging: Identification of protein signatures of genomic instability in colorectal cancers

Author

Gemoll, Timo, Klein, Oliver, Miroll, Elena, Thorns, Christoph, and Habermann, Jens

Abstract

Background: Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) has improved over the years and is increasingly being used for biomarker discovery directly from human tissue. Since DNA aneuploidy has been identified as a prognostic factor for epithelial malignancies, we compared diploid and aneuploid colon cancer tissues of the colorectum by IMS. Material and Methods: DNA image cytometry determined the ploidy status of tissue samples that were subsequently subjected to MALDI-IMS. After obtaining protein and peptide profiles through direct analysis of both, fresh frozen and FFPE tissue sections, a discovery and a validation set were used to predict ploidy and disease status by applying proteomic classification algorithms. Identification of m/z values were performed by using nUPLC mass spectrometry from an adjacent tissue section. Clinical target validations were performed by immunohistochemistry using in-house compiled tissue microarrays (TMA). Results: Classification algorithms categorized normal mucosa and colon carcinoma as well as diploid and aneuploid colon cancers correctly. Proteins could be identified to be differentially expressed between diploid and aneuploid samples that showed expression differences also in clinical samples using a tissue microarray of normal mucosa, diploid and aneuploid colorectal carcinomas. Conclusion: Our data underscore the potential of MALDI-IMS proteomic algorithms for individualized medicine to reveal significant molecular details from distinct tumor subtypes such as different ploidy types., Proceedings on Cancer-Immuno-Oncology, Vol 1 No 1 (2018)

Published
2018
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49. Molecular Characteristics of Diffuse Large B-Cell Lymphoma and Correlation with Baseline Metabolic Tumor Volume (MTV), Interim Positron Emission Tomography (iPET) and Outcome in the PETAL Trial

Author

Richter, Julia, primary, Hüttmann, Andreas, additional, Rekowski, Jan, additional, Schmitz, Christine, additional, Gärtner, Selina, additional, Ose, Claudia, additional, Rosenwald, Andreas, additional, Hansmann, Martin-Leo, additional, Hartmann, Sylvia, additional, Moeller, Peter, additional, Wacker, Hans-Heinrich, additional, Feller, Alfred, additional, Thorns, Christoph, additional, Müller, Stefan P., additional, Duehrsen, Ulrich, additional, and Klapper, Wolfram, additional

Published
2018
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50. Loko-regionär dominante Erdheim Chester Disease (ECD)

Author

Özden, Filiz, Schinke, Susanne, Thorns, Christoph, Eckey, Thomas, Dalhoff, Klaus, Humrich, Jens, Riemekasten, Gabriela, and Lamprecht, Peter

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Vier Patienten mit unterschiedlich organzentrierten Symptomen kamen zur stationären Aufnahme: Bei Patientin 1 bestanden neurologische Symptome, bei Patientin 2 eine rezidivierende globale kardiale Dekompensation und bei Patient 3 und Patientin 4 rezidivierende Schwellungen im Orbita-[zum vollständigen Text gelangen Sie über die oben angegebene URL], 45. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 31. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 27. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2017

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