Search

Your search keyword '"Tarone R"' showing total 390 results
Start Over Author "Tarone R"
390 results on '"Tarone R"'

15. The false-positive to false-negative ratio in epidemiologic studies

Author

Ioannidis, J. P., Tarone, R., and McLaughlin, J. K.

Subjects
Molecular Epidemiology/methods/statistics & numerical data, Data Interpretation, Statistical, Epidemiologic Research Design, Humans, False Positive Reactions, Genome-Wide Association Study/methods/statistics & numerical data, False Negative Reactions
Abstract

The ratio of false-positive to false-negative findings (FP:FN ratio) is an informative metric that warrants further evaluation. The FP:FN ratio varies greatly across different epidemiologic areas. In genetic epidemiology, it has varied from very high values (possibly even >100:1) for associations reported in candidate-gene studies to very low values (1:100 or lower) for associations with genome-wide significance. The substantial reduction over time in the FP:FN ratio in human genome epidemiology has corresponded to the routine adoption of stringent inferential criteria and comprehensive, agnostic reporting of all analyses. Most traditional fields of epidemiologic research more closely follow the practices of past candidate gene epidemiology, and thus have high FP:FN ratios. Further, FP and FN results do not necessarily entail the same consequences, and their relative importance may vary in different settings. This ultimately has implications for what is the acceptable FP:FN ratio and for how the results of published epidemiologic studies should be presented and interpreted. Epidemiology

Published
2011

18. Prostate cancer (PC)-management of 669 cases in Ghana West Africa

Author

Yeboah, E.D., primary, Hsing, A.W., additional, Biritwum, R.B., additional, Tettey, Y., additional, Mante, S., additional, Mensah, J.E., additional, Kyei, Y.M., additional, Yarney, J., additional, Vanderpuije, V., additional, Beechem, K., additional, Asante, K., additional, Ampadu, K., additional, Adusei, B., additional, Attee, S.G., additional, Klufio, G.O., additional, Lamptey, E., additional, Owoo, C., additional, Marzo, A., additional, Netto, G., additional, Yu, K., additional, Li, V., additional, Chokkalingham, A., additional, Chia, D., additional, Jaddalah, S., additional, Partin, A., additional, Thompson, I.M., additional, Quaraishi, S.M., additional, Addo-Ayensu, G., additional, Niwa, S., additional, Tarone, R., additional, and Hoover, R.N., additional

Published
2014
Full Text
View/download PDF

19. Authors' Response

Author

Mclaughlin, J. K., Lipworth, L., Tarone, R. E., Vecchia, C. L., Blot, W. J., Boffetta, P., Mclaughlin, J.K., Lipworth, L., Tarone, R.E., Vecchia, C.L., Blot, W.J., and Boffetta, P.

Subjects
Epidemiology, Response, General Medicine, Author
Abstract

Authors’ Response From JOSEPH K MCLAUGHLIN,1,2 LOREN LIPWORTH,1,2 ROBERT E TARONE,1,2 CARLO LA VECCHIA,3,4 WILLIAM J BLOT1,2 and PAOLO BOFFETTA5

Published
2009
Full Text
View/download PDF

20. Comparison of three management strategies for patients with atypical squamous cells of undetermined significance: baseline results from a randomized trial.

Author

Solomon D, Schiffman M, Tarone R, ALTS Group, Solomon, D, Schiffman, M, Tarone, R, and ALTS Study group

Abstract

Background: More than 2 million U.S. women receive an equivocal cervical cytologic diagnosis (atypical squamous cells of undetermined significance [ASCUS]) each year. Effective colposcopy triage strategies are needed to identify the minority of women who have clinically significant disease while avoiding excessive follow-up evaluation for others.Methods: The ASCUS/LSIL (i.e., low-grade squamous intraepithelial lesion) Triage Study (ALTS) is a multicenter, randomized trial comparing the sensitivity and specificity of the following three management strategies to detect cervical intraepithelial neoplasia grade 3 (CIN3): 1) immediate colposcopy (considered to be the reference standard), 2) triage to colposcopy based on human papillomavirus (HPV) results from Hybrid Capture 2(TM) (HC 2) and thin-layer cytology results, or 3) triage based on cytology results alone. This article summarizes the cross-sectional enrollment results for 3488 women with a referral diagnosis of ASCUS. All statistical tests are two-sided.Results: Among participants with ASCUS, the underlying prevalence of histologically confirmed CIN3 was 5.1%. Sensitivity to detect CIN3 or above by testing for cancer-associated HPV DNA was 96.3% (95% confidence interval [CI] = 91.6% to 98.8%), with 56.1% of women referred to colposcopy. Sensitivity of a single repeat cytology specimen with a triage threshold of HSIL or above was 44.1% (95% CI = 35.6% to 52.9%), with 6.9% referred. Sensitivity of a lower cytology triage threshold of ASCUS or above was 85.3% (95% CI = 78.2% to 90.8%), with 58.6% referred.Conclusions: HC 2 testing for cancer-associated HPV DNA is a viable option in the management of women with ASCUS. It has greater sensitivity to detect CIN3 or above and specificity comparable to a single additional cytologic test indicating ASCUS or above. [ABSTRACT FROM AUTHOR]

Published
2001
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results