1. Docking in metal-organic frameworks
- Author
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Li, Qiaowei, Zhang, Wenyu, Miljanic, Ognjen S., Sue, Chi-Hau, Zhao, Yan-Li, Liu, Lihua, Knobler, Carolyn B., Stoddart, J. Fraser, and Yaghi, Omar M.
- Subjects
Organometallic compounds -- Usage ,Structural frames -- Research ,Science and technology - Abstract
The use of metal-organic frameworks (MOFs) so far has largely relied on nonspecific binding interactions to host small molecular guests. We used long organic struts (~2 nanometers) incorporating 34- and 36-membered macrocyclic polyethers as recognition modules in the construction of several crystalline primitive cubic frameworks that engage in specific binding in a way not observed in passive, open reticulated geometries. MOF-1001 is capable of docking paraquat dication ([PQT.sup.2+]) guests within the macrocycles in a stereoelectronically controlled fashion. This act of specific complexation yields quantitatively the corresponding MOF-1001 pseudorotaxanes, as confirmed by x-ray diffraction and by solid- and solution-state nuclear magnetic resonance spectroscopic studies performed on MOF-1001, its pseudorotaxanes, and their molecular strut precursors. A control experiment involving the attempted inclusion of [PQT.sup.2+] inside a framework (MOF-177) devoid of polyether struts showed negligible uptake of [PQT.sup.2+], indicating the importance of the macrocyclic polyether in [PQT.sup.2+] docking.
- Published
- 2009