2,730 results on '"Sissoko A"'
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2. O-11: AUTOMATED QUANTIFICATION OF POCKED RED BLOOD CELLS CORRELATES WITH SPLEEN SIZE IN SICKLE CELL DISEASE
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SISSOKO A., FRICOT A., ROUSSEL C., MANCEAU S., DUMAS L., CAPITO C., ALLALI S., YEKKACHE N., DUSSIOT M., NGUYEN Y., LEFORT A., AUSSILHOU B., TICHIT M., HARDY D., MAÎTRE B., MICHEL A., DE MONTALEMBERT M., CAVAZZANA M., JOSEPH L., and BUFFET P.
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2022
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3. Infection length and host environment influence on Plasmodium falciparum dry season reservoir
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Andrade, Carolina M, Carrasquilla, Manuela, Dabbas, Usama, Briggs, Jessica, van Dijk, Hannah, Sergeev, Nikolay, Sissoko, Awa, Niangaly, Moussa, Ntalla, Christina, LaVerriere, Emily, Skinner, Jeff, Golob, Klara, Richter, Jeremy, Cisse, Hamidou, Li, Shanping, Hendry, Jason A, Asghar, Muhammad, Doumtabe, Didier, Farnert, Anna, Ruppert, Thomas, Neafsey, Daniel E, Kayentao, Kassoum, Doumbo, Safiatou, Ongoiba, Aissata, Crompton, Peter D, Traore, Boubacar, Greenhouse, Bryan, and Portugal, Silvia
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- 2024
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4. Did It Get Better? The Realities of Queer and Trans Youth of Color in K-12 Schools
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Kevin L. Nadal, Wiston Rodriguez, Emerson Tejeda, D'Andrah Almanzar, Sheharyar Hussain, and D. R. Gina Sissoko
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The lived experiences of queer and trans people of color (QTPOC) youth are significantly influenced by the various environments they navigate -- including but not limited to their families, schools, neighborhoods, communities, and workplaces. QTPOC youth -- or queer and trans youth who identify as Asian American, Black/African American, Indigenous, Hispanic/Latinx, or/and multiracial -- are susceptible to multiple forms of oppression that are embedded in racism, sexism, transphobia, heterosexism, and more. This paper seeks to highlight perspectives of QTPOC youth -- particularly how intersectional identities, discrimination, and victimization influence school experiences and negative educational outcomes. We underscore three major areas that educators must be aware of when working with this subgroup: (a) common experiences for QTPOC youth; (b) QTPOC youth school experiences; and (c) psychosocial determinants affecting school violence. Furthermore, we provide recommendations to consider for working with QTPOC youth, specifically for teachers, school administrators, and families and communities.
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- 2024
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5. Prevalence of high-risk human papillomavirus genotypes in outpatient Malian women living with HIV: a pilot study
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Traore, Ban, Kassogue, Yaya, Diakite, Brehima, Diarra, Fousseyni, Cisse, Kadidiatou, Kassogue, Oumar, Diarra, Modibo, Coulibaly, Aissata, Coulibaly, Bourama, Diallo, Hama, Diarra, Zoumana, Ly, Madani, Maiga, Aminata, Sissoko, Sidi Boula, Sissoko, Adama Seydou, Traore, Cheick Bougadari, Kamate, Bakarou, Teguete, Ibrahima, Bah, Sekou, Dolo, Guimogo, Gursel, Demirkan Besim, Holl, Jane, Hou, Lifang, and Maiga, Mamoudou
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- 2024
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6. Towards clinically relevant dose ratios for Cabamiquine and Pyronaridine combination using P. falciparum field isolate data
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Mohamed Maiga, Laurent Dembele, Perrine Courlet, Akash Khandelwal, Antoine Dara, Fanta Sogore, Ousmaila Diakité, Fatoumata O. Maiga, François Dao, Sekou Sissoko, Yacouba Barre, Siaka Goita, Mahamadou Diakite, Seidina A. S. Diakite, Abdoulaye A. Djimde, Claude Oeuvray, Thomas Spangenberg, Sebastian G. Wicha, and Claudia Demarta-Gatsi
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Science - Abstract
Abstract The selection and combination of dose regimens for antimalarials involve complex considerations including pharmacokinetic and pharmacodynamic interactions. In this study, we use immediate ex vivo P. falciparum field isolates to evaluate the effect of cabamiquine and pyronaridine as standalone treatments and in combination therapy. We feed the data into a pharmacometrics model to generate an interaction map and simulate meaningful clinical dose ratios. We demonstrate that the pharmacometrics model of parasite growth and killing provides a detailed description of parasite kinetics against cabamiquine-susceptible and resistant parasites. Pyronaridine monotherapy provides suboptimal killing rates at doses as high as 720 mg. In contrast, the combination of a single dose of 330 mg cabamiquine and 360 mg pyronaridine provides over 90% parasite killing in most of the simulated patients. The described methodology that combines a rapid, 3R-compliant in vitro method and modelling to set meaningful doses for new antimalarials could contribute to clinical drug development.
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- 2024
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7. Prevalence of high-risk human papillomavirus genotypes in outpatient Malian women living with HIV: a pilot study
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Ban Traore, Yaya Kassogue, Brehima Diakite, Fousseyni Diarra, Kadidiatou Cisse, Oumar Kassogue, Modibo Diarra, Aissata Coulibaly, Bourama Coulibaly, Hama Diallo, Zoumana Diarra, Madani Ly, Aminata Maiga, Sidi Boula Sissoko, Adama Seydou Sissoko, Cheick Bougadari Traore, Bakarou Kamate, Ibrahima Teguete, Sekou Bah, Guimogo Dolo, Demirkan Besim Gursel, Jane Holl, Lifang Hou, and Mamoudou Maiga
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Self-sampling ,WLWHIV ,Hr-HPV ,Genotypes ,Mali ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Introduction Long-term exposure to high-risk human papillomavirus (Hr-HPV) is a well-known necessary condition for development of cervical cancer. The aim of this study is to screen for Hr-HPV using vaginal self-sampling, which is a more effective approach to improve women’s adherence and increase screening rates. Methods This pilot study included a total of 100 Women living with HIV (WLWHIV), recruited from the Center for Listening, Care, Animation, and Counseling of People Living with HIV in Bamako. Hr-HPV genotyping was performed on Self-collected samples using the Cepheid GeneXpert instrument. Results The median age of WLWHIV was 44 (interquartile range [IQR], 37–50) years. Approximately 92% of the study participants preferred self-sampling at the clinic, and 90% opted to receive result notifications via mobile phone contact. The overall prevalence of Hr-HPV among study participants was 42.6%, and the most frequent Hr-HPV sub-types observed were HPV18/45 (19.1%), HPV31/35/33/52/58 (13.8%), and HPV39/68/56/66 (12.8%), followed by HPV16 (5.3%), and HPV51/59 (5.3%). WLWHIV under 35 years of age had a higher frequency of Hr-HPV compared to their older counterparts, with rates of 30% versus 11.1% (p = 0.03). The duration of antiretroviral treatment showed an inverse association with Hr-HPV negativity, with patients on treatment for 15 (IQR, 10–18) years versus 12 (IQR = 7–14) years for Hr-HPV positive patients (95% CI [1.2–5.8], t = 3.04, p = 0.003). WLWHIV with baseline CD4 T-Cell counts below 200 exhibited a higher frequency of Hr-HPV compared to those with baseline CD4 T-Cell counts above 200 (17.9% versus 1.9%, p = 0.009). However, other demographics and clinical factors, such as marital status, age of sexual debut, parity, education, history of abortion, history of preeclampsia, and cesarean delivery, did not influence the distribution of Hr-HPV genotypes. Conclusion Our findings indicate that WLWHIV under the age of 35 years old exhibited the highest prevalence of Hr-HPV infection, with HPV18/45 being the most prevalent subtype. Additionally, WLWHIV with baseline CD4 T-Cell counts below 200 showed the highest infection rates.
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- 2024
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8. HIV testing among female sex workers and associated factors in Burkina Faso: findings from a respondent-driven sampling survey
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Cisse, Kadari, Ouedraogo, Henri Gautier, Ky-zerbo, Odette, Kambire, Dinanibè, Zida, Sylvie, Ki-toe, Célestine, Dioma, Solange, Dahourou, Désiré Lucien, Sissoko, Fatou, Yugbare, Alexandre, Ouedraogo, Abdoul Aziz, Ouedraogo, Abdoul Ibrahim, Ouedraogo, Smaila, and Kouanda, Seni
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- 2024
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9. Towards clinically relevant dose ratios for Cabamiquine and Pyronaridine combination using P. falciparum field isolate data
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Maiga, Mohamed, Dembele, Laurent, Courlet, Perrine, Khandelwal, Akash, Dara, Antoine, Sogore, Fanta, Diakité, Ousmaila, Maiga, Fatoumata O., Dao, François, Sissoko, Sekou, Barre, Yacouba, Goita, Siaka, Diakite, Mahamadou, Diakite, Seidina A. S., Djimde, Abdoulaye A., Oeuvray, Claude, Spangenberg, Thomas, Wicha, Sebastian G., and Demarta-Gatsi, Claudia
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- 2024
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10. The burden of headache and a health-care needs assessment in the adult population of Mali: a cross-sectional population-based study
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Maiga, Youssoufa, Diallo, Seybou H., Sangho, Oumar, Moskatel, Leon Samuel, Konipo, Fatoumata, Bocoum, Abdoulaye, Diallo, Salimata, Coulibaly, Awa, Daou, Mariam, Dolo, Housseini, Sangaré, Modibo, Albakaye, Mohamed, Traoré, Zoumana, Coulibaly, Thomas, Sissoko, Adama, Landouré, Guida, Guindo, Boubacar, Ahamadou, Mahamoudou, Toure, Mahamane Drahamane, Dembele, Abibatou, Sacko, Habib, Kadri Sao, Cheick Abdoul, Coulibaly, Diakalia, Dembele, Salimata, Coulibaly, Cheick Oumar, Sanogo, Mohamadou, Boiguilé, Sekou, Nizard, Julien, Cowan, Robert, Steiner, Timothy J., and Husøy, and Andreas
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- 2024
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11. Higher-order protein assembly controls kinetochore formation
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Sissoko, Gunter B., Tarasovetc, Ekaterina V., Marescal, Océane, Grishchuk, Ekaterina L., and Cheeseman, Iain M.
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- 2024
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12. The burden of headache and a health-care needs assessment in the adult population of Mali: a cross-sectional population-based study
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Youssoufa Maiga, Seybou H. Diallo, Oumar Sangho, Leon Samuel Moskatel, Fatoumata Konipo, Abdoulaye Bocoum, Salimata Diallo, Awa Coulibaly, Mariam Daou, Housseini Dolo, Modibo Sangaré, Mohamed Albakaye, Zoumana Traoré, Thomas Coulibaly, Adama Sissoko, Guida Landouré, Boubacar Guindo, Mahamoudou Ahamadou, Mahamane Drahamane Toure, Abibatou Dembele, Habib Sacko, Cheick Abdoul Kadri Sao, Diakalia Coulibaly, Salimata Dembele, Cheick Oumar Coulibaly, Mohamadou Sanogo, Sekou Boiguilé, Julien Nizard, Robert Cowan, Timothy J. Steiner, and and Andreas Husøy
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Headache ,Medication-overuse headache ,Epidemiology ,Burden of disease ,Health policy ,Mali ,Medicine - Abstract
Abstract Background Our recent studies have shown headache disorders to be very common in the central and western sub-Saharan countries of Benin and Cameroon. Here we report headache in nearby Mali, a strife-torn country that differs topographically, culturally, politically and economically. The purposes were to estimate headache-attributed burden and need for headache care. Methods We used cluster-random sampling in seven of Mali’s eleven regions to obtain a nationally representative sample. During unannounced household visits by trained interviewers, one randomly selected adult member (18–65 years) from each household was interviewed using the structured HARDSHIP questionnaire, with enquiries into headache in the last year and, additionally, headache yesterday (HY). Headache on ≥ 15 days/month (H15+) was diagnosed as probable medication-overuse headache (pMOH) when associated with acute medication use on ≥ 15 days/month, and as “other H15+” when not. Episodic headache (on
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- 2024
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13. Assessing Learners' Needs for Practising Spoken Icelandic L2 with the Mobile App TALADU!
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Sissoko, Fanny and Bédi, Branislav
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This article presents results from a human-centred approach study to designing a mobile app TALAÐU!, which aims at assisting learners of Icelandic as a second language (L2) with spoken language practice. The main goal of the app would be to encourage learners to have real-life conversations with Icelandic speakers by accomplishing conversational missions. In the first stage of development, a qualitative deep-method needs study in the form of interviews was conducted with 19 migrants from 14 different countries, who permanently live in Iceland. Results indicated that learners have five core needs for practising spoken language: connection, confidence, clarity, growth, and convenience. Based on different learning styles and confidence in speaking rather than language ability, three main learner profiles were indicated: 'diving in', 'learning with caution' and 'dipping a toe'. Both the learners' needs and the profiles would drive the design of the learning app to personalise and maximise the learner experience with practising spoken L2. This human-centred study approach suggests an innovative strategy in designing a learning app for practising L2 in a specific language and culture environment. [For the complete volume, "CALL and Professionalisation: Short Papers from EUROCALL 2021 (29th, Online, August 26-27, 2021)," see ED616972.]
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- 2021
14. Les implications sociétales de l’éducation familiale au Mali face au développement durable
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Amadou TRAORE & Abdoulaye Habib SISSOKO
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Language and Literature - Abstract
Résumé : Ce travail porte sur les implications sociétales de la famille dans le cadre du développement durable et de la RSE. Il s’agit d’un travail théorique réalisé à travers l’usage des techniques d’entretien semi directif et des recherches documentaires. L’objectif principal de ce papier est de mettre en emphase les implications sociétales de la grande famille traditionnelle type au Mali face à la responsabilité sociétale. Il ressort des analyses que la famille peut contribuer au management des entreprises à travers la construction citoyenne et son modèle de fonctionnement, dont certains éléments pourront inspirer l’organisation des entreprises pour plus d’innovations et de responsabilité sociale et sociétale. Mots-clés : éducation familiale, implications sociétales, Mali, management, responsabilité
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- 2024
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15. Cross-country evidence of consumers’ perception of food from animals fed on insects in DR Congo, Mali, and Niger
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Paul-Martin Dontsop Nguezet, Dieu-Merci Akonkwa Nyamuhirwa, Feleke Shiferaw, Victor Manyong, Dioukou Sissoko, Bokar Moussa, Abel-Gautier Kouakou, Seydou Zakari, and Tahirou Abdoulaye
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Insects ,Black-solider fly larvae ,Animal feed ,Food products ,Consumers' perception ,Africa ,Agriculture (General) ,S1-972 ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Insects can represent a valuable and cost effective source of animal feed in Africa. Recently, the interest in incorporating black-soldier fly larvae (BSFL) in animal feed has increased tremendously. However, many factors, including food neophobia and social and cultural context may affect consumers' perception of insect-technologies-derived food products. This study shed light on consumers' perception of the usage of BSFL as animal feed and consumption, buying, and commercialization of food from animals fed on BSFL in DR Congo, Mali, and Niger. We used data from 1560 consumers that were analyzed applying parametric and non-parametric tests and the generalized ordered logit model. Our findings show that about 87 % of respondents consider that consuming food from animals fed on BSFL is acceptable and 34 % accept buying eggs, fish, and meat from animals fed on BSFL. However, about 40 % of consumers recommend the label differentiation of BSF-technologies-derived food products and they also expect a lower price than conventional animal feed products. The analysis of factors driving consumers' readiness to buy BSF-derived food products have revealed that effective market penetration of BSF-technologies-derived food products could be achieved with great awareness creation, targeting farming households, married and literate heads. Furthermore, strategic communication and intensive sensitization through farmers' associations will be crucial. Finally, credit access and income diversification are also necessary to support consumers’ choices toward sustainable food habits built on bio-circular economy.
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- 2024
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16. 3D‐printed neck phantoms with detailed anatomy for ultrasound‐guided procedure and device testing
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Aida M. Hasson, Rahul D. Patel, Cheick A. Sissoko, Laura Brattain, and Gregory R. Dion
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3D printing ,agar ,anatomical phantom ,cervical vertebrae ,device testing ,echogenicity ,Otorhinolaryngology ,RF1-547 ,Surgery ,RD1-811 - Abstract
Abstract Objectives With rapid advances in ultrasound‐guided procedures, there is an unmet need for echogenic phantoms with sufficient anatomical details for artificial intelligence and ultrasound‐guided device testing. We developed a method for creating neck phantoms for novel otolaryngology‐related device testing. To achieve accurate representation of the anatomy, we utilized CT scans and 3D printing technology to create customized agar molds, thus providing high‐fidelity yet cost‐effective tools. Methods Based on previous studies, the key components in our neck phantom include the cervical vertebrae, trachea, common carotid arteries, internal jugular veins, thyroid gland, and surrounding soft tissue. Open‐source image analysis software were employed to process CT data to generate high fidelity 3D models of the target structures. Resin molds were 3D printed and filled with various agar mixtures to mimic anatomical echogenicity. Results Following the method proposed, we successfully assembled the neck phantom which provided a detailed representation of the target structures. To evaluate the results, ultrasound data was collected on the phantom and living tissue and analyzed with ImageJ. We were able to demonstrate echogenicity comparable to that of living tissue. Conclusion The proposed method for building neck phantoms with detailed anatomical features offers a valuable, detailed, low‐cost tool for medical training and device testing in otolaryngology, particularly for novel devices that involve artificial intelligence (AI) guidance and robotic‐based needle insertion. Additional anatomical refinements and validation studies could further enhance the consistency and accuracy, thus paving the way for future advancements in ultrasound training and research, and ultimately benefiting patient care and safety.
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- 2024
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17. Clinicopathological discrepancies in the diagnoses of childhood causes of death in the CHAMPS network: An analysis of antemortem diagnostic inaccuracies
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Khatia Munguambe, Quique Bassat, Robert F Breiman, Mahbubur Rahman, Sibone Mocumbi, Cynthia G Whitney, Amy Wise, Shams El Arifeen, Meerjady Sabrina Flora, Soter Ameh, Emily S Gurley, Mustafizur Rahman, Ariel Nhacolo, Carla Carrilho, Cheick Bougadari Traore, Lucy Liu, Inacio Mandomando, Clara Menendez, Chris A Rees, Janet Agaya, Jane Juma, Tadesse Gure, George Aol, Hennie Lombaard, Ziyaad Dangor, Shabir Madhi, James Bunn, Samba O Sow, Dickson Gethi, Sanwarul Bari, Jeffrey P Koplan, Natalia Rakislova, Fabiola Fernandes, Tacilta Nhampossa, Maria Maixenchs, Mohammed Kamal, Nega Assefa, Joseph Oundo, Lola Madrid, Tahmina Shirin, Nelesh P Govender, Addisu Alemu, Hailemariam Legesse, Uma U Onwuchekwa, Awa Traore, Portia C Mutevedzi, Victor Akelo, Sammy Khagayi, Dickens Onyango, Richard Omore, Yasmin Adam, Peter Otieno, Margaret Mannah, Vicky Baillie, Karen L Kotloff, John Blevins, Milagritos D Tapia, Rima Koka, Mohammad Zahid Hossain, Dickens Kowuor, Tom Sesay, James Squire, Francis Moses, Haleluya Leulseged, Christine Bethencourt, Kitiezo Aggrey Igunza, Ikechukwu U Ogbuanu, Andrew Moseray, Ima-Abasi Bassey, Afruna Rahman, Muntasir Alam, Yasir Y Abdullahi, Nana Kourouma, Seydou Sissoko, Rosauro Varo, Sana Mahtab, Martin Hale, Jeanie du Toit, Zachary J Madewell, Dianna M Blau, Roosecelis B Martines, Fatima Solomon, Gillian Sorour, Jeannette Wadula, Karen Petersen, Peter J Swart, Sanjay G Lala, Sithembiso Velaphi, Richard Chawana, Ashleigh Fritz, Nellie Myburgh, Pedzisai Ndagurwa, Cleopas Hwinya, Shahana Parveen, ASM Nawshad Uddin Ahmed, Mahbubul Hoque, Saria Tasnim, Ferdousi Islam, Farida Ariuman, Mohammad Mosiur Rahman, Ferdousi Begum K Zaman, Dilruba Ahmed, Alexander M Ibrahim, Fikremelekot Temesgen, Melisachew Mulatu Yeshi, Mahlet Abayneh Gizaw, Stian MS Orlien, Solomon Ali, Peter Nyamthimba Onyango, Richard Oliech, Joyce Akinyi Were, Thomas Misore, Harun Owuor, Christopher Muga, Bernard Oluoch, Christine Ochola, Sharon M Tennant, Carol L Greene, Ashka Mehta, J Kristie Johnson, Brigitte Gaume, Adama Mamby Keita, Karen D Fairchild, Diakaridia Kone, Diakaridia Sidibe, Doh Sanogo, Kounandji Diarra, Tiéman Diarra, Kiranpreet Chawla, Zara Manhique, Fatmata Bintu Tarawally, Martin Seppeh, Ronald Mash, Julius Ojulong, Babatunde Duduyemi, Alim Swaray-Deen, Joseph Bangura Amara Jambai, Okokon Ita, Cornell Chukwuegbo, Sulaiman Sannoh, Princewill Nwajiobi, Erick Kaluma, Oluseyi Balogun, Carrie Jo Cain, Solomon Samura, Samuel Pratt, Joseph Kamanda Sesay, Osman Kaykay, Binyam Halu, Francis Smart, Sartie Kenneh, Jana Ritter, Tais Wilson, Jonas Winchell, Jakob Witherbee, Navit T Salzberg, Margaret Basket, Ashutosh Wadhwa, Kyu Han Lee, Roosecelis Martines, Shamta Warang, Maureen Diaz, Jessica Waller, Shailesh Nair, Courtney Bursuc, Kristin LaHatte, Sarah Raymer, Solveig Argeseanu, Kurt Vyas, and Manu Bhandari
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Pediatrics ,RJ1-570 - Abstract
Introduction Determining aetiology of severe illness can be difficult, especially in settings with limited diagnostic resources, yet critical for providing life-saving care. Our objective was to describe the accuracy of antemortem clinical diagnoses in young children in high-mortality settings, compared with results of specific postmortem diagnoses obtained from Child Health and Mortality Prevention Surveillance (CHAMPS).Methods We analysed data collected during 2016–2022 from seven sites in Africa and South Asia. We compared antemortem clinical diagnoses from clinical records to a reference standard of postmortem diagnoses determined by expert panels at each site who reviewed the results of histopathological and microbiological testing of tissue, blood, and cerebrospinal fluid. We calculated test characteristics and 95% CIs of antemortem clinical diagnostic accuracy for the 10 most common causes of death. We classified diagnostic discrepancies as major and minor, per Goldman criteria later modified by Battle.Results CHAMPS enrolled 1454 deceased young children aged 1–59 months during the study period; 881 had available clinical records and were analysed. The median age at death was 11 months (IQR 4–21 months) and 47.3% (n=417) were female. We identified a clinicopathological discrepancy in 39.5% (n=348) of deaths; 82.3% of diagnostic errors were major. The sensitivity of clinician antemortem diagnosis ranged from 26% (95% CI 14.6% to 40.3%) for non-infectious respiratory diseases (eg, aspiration pneumonia, interstitial lung disease, etc) to 82.2% (95% CI 72.7% to 89.5%) for diarrhoeal diseases. Antemortem clinical diagnostic specificity ranged from 75.2% (95% CI 72.1% to 78.2%) for diarrhoeal diseases to 99.0% (95% CI 98.1% to 99.6%) for HIV.Conclusions Antemortem clinical diagnostic errors were common for young children who died in areas with high childhood mortality rates. To further reduce childhood mortality in resource-limited settings, there is an urgent need to improve antemortem diagnostic capability through advances in the availability of diagnostic testing and clinical skills.
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- 2024
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18. Beyond grain: the potential of cowpea in local markets of Mali
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Sissoko, Mamadou, Theriault, Veronique, and Smale, Melinda
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- 2024
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19. Effects of two Ralstonia Solanacearum strains on Yield of Tomato (Lycopersicon esculentum Mills 1768) Genotypes Planted at Three Different Planting Seasons at the Sotuba Station, Sudano-Sahelian Area of Mali
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Sory Sissoko, Abdoulaye Youssouf Camara, Mamadou Oumar Diawara, Allihoun Diarra, Ibrehima Dembélé, Aminata Dolo, Seriba Ousmane Katile, and Kadiatou Toure
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tomato ,r. solanacearum ,yield ,period of growing ,mali ,Biochemistry ,QD415-436 - Abstract
The tomato, a genus of Lycopersicon, is cultivated worldwide for fruit. It is an important gastronomic ingredient and an important source of income for small farmers in Mali. However, its production faces a number of phytosanitary constraints that are still poorly understood. Among phytosanitary problems, bacterial wilt, caused by R. solanacearum, is proving to be the most dangerous and devastating of all tomato crops in Mali. The aim of this study is to contribute to the improvement of tomato production in Mali by identifying tomato varieties tolerant to R. solanacearum and adapted to the growing periods. To achieve this objective, trials under artificial and natural infestation conditions with 12 tomato genotypes during three periods were conducted at the Sotuba research station from December 2018 to December 2019. Analysis of variance revealed no significant difference between the two strains tested. Both strains were more severe, especially in period 2 of the experiment. The Caraïbo variety was the most susceptible to both strains, with an average severity rate of 2.8 (≈3) and the most stress-susceptibility index (0.69). The varieties Carioca and SF-83-61 were the most productive in both experimental conditions. With average yields ≥ 3.5 t/ha under artificial infestation conditions and ≥ 6 t/ha under natural conditions. In contrast, the Roma and Rossol varieties recorded the lowest yields. To minimize R. Solanacearum damage and improve field yields at all cropping periods, the SF-83-61 and Carioca varieties may be recommended for release in areas where R. Solanacearum, responsible for bacterial wilt, causes significant damage in tomato crops after confirmation tests.
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- 2024
20. Cross-country evidence of consumers’ perception of food from animals fed on insects in DR Congo, Mali, and Niger
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Dontsop Nguezet, Paul-Martin, Akonkwa Nyamuhirwa, Dieu-Merci, Shiferaw, Feleke, Manyong, Victor, Sissoko, Dioukou, Moussa, Bokar, Kouakou, Abel-Gautier, Zakari, Seydou, and Abdoulaye, Tahirou
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- 2024
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21. Safe drugs with high potential to block malaria transmission revealed by a spleen-mimetic screening
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Carucci, Mario, Duez, Julien, Tarning, Joel, García-Barbazán, Irene, Fricot-Monsinjon, Aurélie, Sissoko, Abdoulaye, Dumas, Lucie, Gamallo, Pablo, Beher, Babette, Amireault, Pascal, Dussiot, Michael, Dao, Ming, Hull, Mitchell V., McNamara, Case W., Roussel, Camille, Ndour, Papa Alioune, Sanz, Laura Maria, Gamo, Francisco Javier, and Buffet, Pierre
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- 2023
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22. La légitimité des membres des assemblées citoyennes : une fausse idée claire
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Marie Sissoko-Noblot
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conventions citoyennes ,démocratie participative ,démocratie délibérative ,délibération ,participation ,légitimité ,citizens’ conventions ,participatory democracy ,deliberative democracy ,deliberation, participation ,legitimacy ,Political science (General) ,JA1-92 ,Sociology (General) ,HM401-1281 - Abstract
La question de la légitimité des membres des assemblées citoyennes est un aspect peu étudié des exercices délibératifs et participatifs. Les membres des assemblées citoyennes, s’ils sont des acteurs clés des innovations institutionnelles, devraient disposer d’un statut juridique clairement défini afin de renforcer leur légitimité juridique. Si leur légitimité politique est forte, le vocable d’« assemblée citoyenne » contribue en partie à brouiller le cadre de leur légitimité. Une étude de la légitimité de celles-ci peut être nourrie par une analyse des deux dernières expériences françaises d’assemblée citoyenne que sont la Convention citoyenne pour le climat et la Convention citoyenne sur la fin de vie. L’utilisation du vocable d’« assemblée citoyenne » a un impact direct sur la légitimité des membres des exercices participatifs et contribue à en faire une fausse idée claire. La pérennisation des exercices délibératifs et participatifs au sein du système constitutionnel ne pourra s’opérer qu’au prix d’une clarification du statut des acteurs impliqués.
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- 2024
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23. Optimizing type, date, and dose of compost fertilization of organic cotton under climate change in Mali: A modeling study.
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Ginette Dembélé, Romain Loison, Amadou Traoré, Sidiki Gabriel Dembélé, and Fagaye Sissoko
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Medicine ,Science - Abstract
Adapting organic farming to climate change is a major issue. Cotton yields in Mali are declining due to deteriorating climatic conditions, soil fertility, and poor management. This study aimed to improve organic cotton yield in Mali in the future climate with the optimal choice of compost type, date, and dose of application. Experimental data collected in 2021 from the Sotuba research station in Mali was used for calibration and evaluation of the crop model DSSAT CSM-CROPGRO-Cotton model using phenology, leaf area index, and seed cotton yield. Climate data from the RCP4.5 and RCP8.5 scenarios of the GFDL-ESM2M model were used for future weather datasets for 2020-2039, 2040-2059, and 2060-2079. The model was able to simulate anthesis and maturity with excellent results, with nRMSE < 4%, and seed cotton yields moderately well, an nRMSE of 26% during calibration and 20.3% in evaluation. The scenario RCP8.5 from 2060 to 2079 gave the best seed cotton yields. Seed cotton yields with RCP4.5 and RCP8.5 were all better with the mid-May application period of small ruminant silo compost at 7.5 t/ha. In such conditions, more than 75% of the cases would produce more than 2000 kg/ha of seed cotton.
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- 2024
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24. Crowding in during the Seven Years’ War
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Nuno Palma and Carolyn Sissoko
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N13 ,N23 ,N43 ,Economics as a science ,HB71-74 - Abstract
We present a financial history of the Seven Years’ War (1756–1763) using a new dataset derived from the Bank of England minutes. We argue that the war and the associated actions of the Bank of England led to a transformation of the financial system. Additionally, while there was short-term crowding out of private investment when interest rates rose due to the issue of war-related government debt, in the long-run there was crowding in: government spending led to an increase in private sector investment.
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- 2024
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- View/download PDF
25. Genome-wide association study and functional validation implicates JADE1 in tauopathy
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Farrell, Kurt, Kim, SoongHo, Han, Natalia, Iida, Megan A, Gonzalez, Elias M, Otero-Garcia, Marcos, Walker, Jamie M, Richardson, Timothy E, Renton, Alan E, Andrews, Shea J, Fulton-Howard, Brian, Humphrey, Jack, Vialle, Ricardo A, Bowles, Kathryn R, de Paiva Lopes, Katia, Whitney, Kristen, Dangoor, Diana K, Walsh, Hadley, Marcora, Edoardo, Hefti, Marco M, Casella, Alicia, Sissoko, Cheick T, Kapoor, Manav, Novikova, Gloriia, Udine, Evan, Wong, Garrett, Tang, Weijing, Bhangale, Tushar, Hunkapiller, Julie, Ayalon, Gai, Graham, Robert R, Cherry, Jonathan D, Cortes, Etty P, Borukov, Valeriy Y, McKee, Ann C, Stein, Thor D, Vonsattel, Jean-Paul, Teich, Andy F, Gearing, Marla, Glass, Jonathan, Troncoso, Juan C, Frosch, Matthew P, Hyman, Bradley T, Dickson, Dennis W, Murray, Melissa E, Attems, Johannes, Flanagan, Margaret E, Mao, Qinwen, Mesulam, M-Marsel, Weintraub, Sandra, Woltjer, Randy L, Pham, Thao, Kofler, Julia, Schneider, Julie A, Yu, Lei, Purohit, Dushyant P, Haroutunian, Vahram, Hof, Patrick R, Gandy, Sam, Sano, Mary, Beach, Thomas G, Poon, Wayne, Kawas, Claudia H, Corrada, María M, Rissman, Robert A, Metcalf, Jeff, Shuldberg, Sara, Salehi, Bahar, Nelson, Peter T, Trojanowski, John Q, Lee, Edward B, Wolk, David A, McMillan, Corey T, Keene, C Dirk, Latimer, Caitlin S, Montine, Thomas J, Kovacs, Gabor G, Lutz, Mirjam I, Fischer, Peter, Perrin, Richard J, Cairns, Nigel J, Franklin, Erin E, Cohen, Herbert T, Raj, Towfique, Cobos, Inma, Frost, Bess, Goate, Alison, White III, Charles L, and Crary, John F
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Biomedical and Clinical Sciences ,Neurosciences ,Neurodegenerative ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Brain Disorders ,Genetics ,Dementia ,Acquired Cognitive Impairment ,Frontotemporal Dementia (FTD) ,Aging ,Alzheimer's Disease ,Aetiology ,2.1 Biological and endogenous factors ,Neurological ,Aged ,Aged ,80 and over ,Animals ,Cohort Studies ,Drosophila ,Female ,Genome-Wide Association Study ,Homeodomain Proteins ,Humans ,Male ,Middle Aged ,Polymorphism ,Single Nucleotide ,Tauopathies ,Tumor Suppressor Proteins ,Clinical Sciences ,Neurology & Neurosurgery - Abstract
Primary age-related tauopathy (PART) is a neurodegenerative pathology with features distinct from but also overlapping with Alzheimer disease (AD). While both exhibit Alzheimer-type temporal lobe neurofibrillary degeneration alongside amnestic cognitive impairment, PART develops independently of amyloid-β (Aβ) plaques. The pathogenesis of PART is not known, but evidence suggests an association with genes that promote tau pathology and others that protect from Aβ toxicity. Here, we performed a genetic association study in an autopsy cohort of individuals with PART (n = 647) using Braak neurofibrillary tangle stage as a quantitative trait. We found some significant associations with candidate loci associated with AD (SLC24A4, MS4A6A, HS3ST1) and progressive supranuclear palsy (MAPT and EIF2AK3). Genome-wide association analysis revealed a novel significant association with a single nucleotide polymorphism on chromosome 4 (rs56405341) in a locus containing three genes, including JADE1 which was significantly upregulated in tangle-bearing neurons by single-soma RNA-seq. Immunohistochemical studies using antisera targeting JADE1 protein revealed localization within tau aggregates in autopsy brains with four microtubule-binding domain repeats (4R) isoforms and mixed 3R/4R, but not with 3R exclusively. Co-immunoprecipitation in post-mortem human PART brain tissue revealed a specific binding of JADE1 protein to four repeat tau lacking N-terminal inserts (0N4R). Finally, knockdown of the Drosophila JADE1 homolog rhinoceros (rno) enhanced tau-induced toxicity and apoptosis in vivo in a humanized 0N4R mutant tau knock-in model, as quantified by rough eye phenotype and terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL) in the fly brain. Together, these findings indicate that PART has a genetic architecture that partially overlaps with AD and other tauopathies and suggests a novel role for JADE1 as a modifier of neurofibrillary degeneration.
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- 2022
26. Additional material on the legend of Sundiata
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Sissoko, Habibou, primary
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- 2023
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27. Innovations and Resources
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Forrest, Jeffrey Yi-Lin, Baizakov, Sailau, Liu, Yong, Haile, Yohannes G., Golden, John, Gyan, Abel, Sissoko, Yaya, Li, Qiaoxing, Kijima, Kyoichi, Editor-in-Chief, Deguchi, Hiroshi, Editor-in-Chief, and Forrest, Jeffrey Yi-Lin
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- 2023
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28. Post-mortem investigation of deaths due to pneumonia in children aged 1–59 months in sub-Saharan Africa and South Asia from 2016 to 2022: an observational study
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Adam, Yasmin, Agaya, Janet, Ahmed, A.S.M. Nawshad Uddin, Ahmed, Dilruba, Alemu, Addisu, Ali, Solomon, Ameh, Soter, Aol, George, Argeseanu, Solveig, Ariuman, Farida, Balogun, Oluseyi, Bari, Sanwarul, Basket, Margaret, Begum, Ferdousi, Bhandari, Manu, Blevins, John, Bunn, James, Bursuc, Courtney, Cain, Carrie Jo, Chawana, Richard, Chawla, Kiranpreet, Chukwuegbo, Cornell, Diarra, Kounandji, Diarra, Tiéman, Diaz, Maureen, Duduyemi, Babatunde, Fairchild, Karen D., Flora, Meerjady Sabrina, Fritz, Ashleigh, Garel, Mischka, Gaume, Brigitte, Gizaw, Mahlet Abayneh, Govender, Nelesh P., Greene, Carol L., Gure, Tadesse, Halu, Binyam, Hoque, Mahbubul, Hwinya, Cleopas, Ibrahim, Alexander M., Igunza, Kitiezo Aggrey, Islam, Ferdousi, Ita, Okokon, Jambai, Amara, Johnson, J. Kristie, Juma, Jane, Kaluma, Erick, Kamal, Mohammed, Kaykay, Osman, Kenneh, Sartie, Khagayi, Sammy, Koka, Rima, Kone, Diakaridia, Koplan, Jeffrey P., Kourouma, Nana, Kowuor, Dickens, LaHatte, Kristin, Lala, Sanjay G., Lee, Kyu Han, Liu, Lucy, Lombaard, Hennie, Maixenchs, Maria, Manhique, Zara, Mannah, Margaret, Martines, Roosecelis, Mash, Ronald, Mehta, Ashka, Menéndez, Clara, Misore, Thomas, Mocumbi, Sibone, Moseray, Andrew, Moses, Francis, Muga, Christopher, Munguambe, Khátia, Myburgh, Nellie, Nair, Shailesh, Ndagurwa, Pedzisai, Nhacolo, Ariel, Nhampossa, Tacilta, Nwajiobi, Princewill, Ochola, Christine, Oliech, Richard, Oluoch, Bernard, Onwuchekwa, Uma U., Onyango, Peter Nyamthimba, Orlien, Stian MS, Otieno, Peter, Oundo, Joseph, Owuor, Harun, Parveen, Shahana, Petersen, Karen, Pratt, Samuel, Rahman, Mahbubur, Rahman, Mohammad Mosiur, Rahman, Mustafizur, Raymer, Sarah, Ritter, Jana, Salzberg, Navit T., Samura, Solomon, Sannoh, Sulaiman, Sanogo, Doh, Seppeh, Martin, Sesay, Tom, Sesay, Joseph Kamanda, Shirin, Tahmina, Sissoko, Seydou, Smart, Francis, Sorour, Gillian, Squire, James, Swaray-Deen, Alim, Swart, Peter J., Tarawally, Fatmata Bintu, Tasnim, Saria, Temesgen, Fikremelekot, Tennant, Sharon M., Traore, Cheick Bougadari, Traore, Awa, Velaphi, Sithembiso, Vyas, Kurt, Wadhwa, Ashutosh, Wadula, Jeannette, Waller, Jessica, Wanga, Valentine, Warang, Shamta, Were, Joyce Akinyi, Wilson, Tais, Winchell, Jonas, Wise, Amy, Witherbee, Jakob, Yeshi, Melisachew Mulatu, Zaman, K., Mahtab, Sana, Blau, Dianna M, Madewell, Zachary J, Ogbuanu, Ikechukwu, Ojulong, Julius, Lako, Sandra, Legesse, Hailemariam, Bangura, Joseph S, Bassat, Quique, Mandomando, Inacio, Xerinda, Elisio, Fernandes, Fabiola, Varo, Rosauro, Sow, Samba O, Kotloff, Karen L, Tapia, Milagritos D, Keita, Adama Mamby, Sidibe, Diakaridia, Onyango, Dickens, Akelo, Victor, Gethi, Dickson, Verani, Jennifer R, Revathi, Gunturu, Scott, J Anthony G, Assefa, Nega, Madrid, Lola, Bizuayehu, Hiwot, Tirfe, Tseyon Tesfaye, El Arifeen, Shams, Gurley, Emily S, Islam, Kazi Munisul, Alam, Muntasir, Zahid Hossain, Mohammad, Dangor, Ziyaad, Baillie, Vicky L, Hale, Martin, Mutevedzi, Portia, Breiman, Robert F, Whitney, Cynthia G, and Madhi, Shabir A
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- 2024
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29. Modeling clinical malaria episodes in different ecological settings in Mali, 2018-2022
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Kane, Fousseyni, Toure, Mahamoudou, Sogoba, Nafomon, Traore, Bourama, Keita, Moussa, Konate, Drissa, Diawara, Sory Ibrahim, Sanogo, Daouda, Keita, Soumba, Sanogo, Ibrahim, Doumbia, Cheick Oumar, Keïta, Bourama, Traoré, Amadou Sekou, Sissoko, Ibrahim, Coulibaly, Hamady, Thiam, Sidibé M'Baye, Barry, Alyssa, Shaffer, Jeffey G., Diakite, Mahamadou, and Doumbia, Seydou
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- 2024
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30. Crowding in during the Seven Years’ War
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Palma, Nuno and Sissoko, Carolyn
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- 2024
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31. Factors explaining the shortage and poor retention of qualified health workers in rural and remote areas of the Kayes, region of Mali: A qualitative study
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Ahmed, Mohamed Ali Ag, Diakite, Soumaila Laye, Sissoko, Koman, Gagnon, Marie-Pierre, and Charron, Sylvie
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- 2020
32. Genome-wide association study and functional validation implicates JADE1 in tauopathy
- Author
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Farrell, Kurt, Kim, SoongHo, Han, Natalia, Iida, Megan A, Gonzalez, Elias, Otero-Garcia, Marcos, Walker, Jamie, Richardson, Tim, Renton, Alan E, Andrews, Shea J, Fulton-Howard, Brian, Humphrey, Jack, Vialle, Ricardo A, Bowles, Kathryn R, Whitney, Kristen, Dangoor, Diana K, Marcora, Edoardo, Hefti, Marco M, Casella, Alicia, Sissoko, Cheick, Kapoor, Manav, Novikova, Gloriia, Udine, Evan, Wong, Garrett, Tang, Weijing, Bhangale, Tushar, Hunkapiller, Julie, Ayalon, Gai, Graham, Rob, Cherry, Jonathan D, Cortes, Etty, Borukov, Valeriy, McKee, Ann C, Stein, Thor D, Vonsattel, Jean-Paul, Teich, Andy F, Gearing, Marla, Glass, Jonathan, Troncoso, Juan C, Frosch, Matthew P, Hyman, Bradley T, Dickson, Dennis W, Murray, Melissa E, Attems, Johannes, Flanagan, Margaret E, Mao, Qinwen, Mesulam, M-Marsel, Weintraub, Sandra, Woltjer, Randy, Pham, Thao, Kofler, Julia, Schneider, Julie A, Yu, Lei, Purohit, Dushyant P, Haroutunian, Vahram, Hof, Patrick R, Gandy, Sam, Sano, Mary, Beach, Thomas G, Poon, Wayne, Kawas, Claudia, Corrada, María, Rissman, Robert A, Metcalf, Jeff, Shuldberg, Sara, Salehi, Bahar, Nelson, Peter T, Trojanowski, John Q, Lee, Edward B, Wolk, David A, McMillan, Corey T, Keene, Dirk C, Montine, Thomas J, Kovacs, Gabor G, Lutz, Mirjam I, Fischer, Peter, Perrin, Richard J, Cairns, Nigel, Franklin, Erin E, Cohen, Herbert T, Sillero, Maria Inmaculada Cobos, Frost, Bess, Raj, Towfique, Goate, Alison, White, Charles L, and Crary, John F
- Subjects
Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Genetics ,Dementia ,Alzheimer's Disease ,Frontotemporal Dementia (FTD) ,Brain Disorders ,Neurosciences ,Biotechnology ,Neurodegenerative ,Aging ,Acquired Cognitive Impairment ,Aetiology ,2.1 Biological and endogenous factors ,Neurological - Abstract
AbstractPrimary age-related tauopathy (PART) is a neurodegenerative tauopathy with features distinct from but also overlapping with Alzheimer disease (AD). While both exhibit Alzheimer-type temporal lobe neurofibrillary degeneration alongside amnestic cognitive impairment, PART develops independently of amyloid-β (Aβ) deposition in plaques. The pathogenesis of PART is unknown, but evidence suggests it is associated with genes that promote tau pathology as well as others that protect from Aβ toxicity. Here, we performed a genetic association study in an autopsy cohort of individuals with PART (n=647) using Braak neurofibrillary tangle stage as a quantitative trait adjusting for sex, age, genotyping platform, and principal components. We found significant associations with some candidate loci associated with AD and progressive supranuclear palsy, a primary tauopathy (SLC24A4, MS4A6A, HS3ST1, MAPT and EIF2AK3). Genome-wide association analysis revealed a novel significant association with a single nucleotide polymorphism on chromosome 4 (rs56405341) in a locus containing three genes, including JADE1 which was significantly upregulated in tangle-bearing neurons by single-soma RNA-seq. Immunohistochemical studies using antisera targeting JADE1 protein revealed localization within tau aggregates in autopsy brain from tauopathies containing isoforms with four microtubule-binding domain repeats (4R) and mixed 3R/4R, but not with 3R exclusively. Co-immunoprecipitation revealed a direct and specific binding of JADE1 protein to tau containing four (4R) and no N-terminal inserts (0N4R) in post-mortem human PART brain tissue. Finally, knockdown of the Drosophila JADE1 homolog rhinoceros (rno) enhanced tau-induced toxicity and apoptosis in vivo in a humanized 0N4R mutant tau knock-in model as quantified by rough eye phenotype and terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL) in the fly brain. Together, these findings indicate that PART has a genetic architecture that partially overlaps with AD and other tauopathies and suggests a novel role for JADE1 as a mediator of neurofibrillary degeneration.
- Published
- 2021
33. Safe drugs with high potential to block malaria transmission revealed by a spleen-mimetic screening
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Mario Carucci, Julien Duez, Joel Tarning, Irene García-Barbazán, Aurélie Fricot-Monsinjon, Abdoulaye Sissoko, Lucie Dumas, Pablo Gamallo, Babette Beher, Pascal Amireault, Michael Dussiot, Ming Dao, Mitchell V. Hull, Case W. McNamara, Camille Roussel, Papa Alioune Ndour, Laura Maria Sanz, Francisco Javier Gamo, and Pierre Buffet
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Science - Abstract
Authors propose their splenic mimetic filtration method, microsphiltration, and utilise this approach in a drug-screen, to identify compounds that induce a stiffening effect on Plasmodium falciparum-infected erythrocytes. They proceed to assess safety and tolerability of one identified compound in a phase I clinical trial.
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- 2023
- Full Text
- View/download PDF
34. Socio-cultural representation of epilepsy at the teaching hospital of point G, Mali
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Th Coulibaly, O.A. Dicko, M. Sangaré, A.S. Sissoko, L. Cissé, G. Landouré, S.O. Djimdé, A. Yalcouyé, T. Coulibaly, M. Karambé, Y.M. Maiga, and C.O. Guinto
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Epilepsy ,Burden ,Limited resources setting ,Mali ,Africa ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Background: Epilepsy is a significant public health concern with psychosocial impacts, including fear, stigma, and misconceptions. These factors contribute to human rights violations and discrimination. The objective of this study was to describe the sociocultural representation of epilepsy in Mali. Materials and methods: This cross-sectional descriptive study was carried out from April 2015 to November 2016 at the University Hospital of Point G. Patients with epilepsy were identified prospectively, and a questionnaire was administered to each patient and their parents. Results: A total of 104 patients were enrolled with an average age of 35 years, ranging from 15 to 89 years. Males were slightly predominant, accounting for 53.85%, resulting in a sex ratio (M/F) of 1.17. In terms of occupation, workers comprised 68.27% of participants. Patients residing in urban areas represented 61.54%, and the most level of education was secondary (40.38%). The majority of patients (57.69%) and their relatives (69.23%) thought that epilepsy was caused by mystical causes. Stigma was reported by 66.35% of our patients. Conclusion: The sociocultural perception of epilepsy hinders evidence-based diagnosis and management in Africa. This study suggests a need to focus on raising awareness to change these misconceptions.
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- 2023
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35. Sporozoite immunization: Innovative Translational Science to Support the Fight against malaria
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Thomas L. Richie, L.W. Preston Church, Tooba Murshedkar, Peter F. Billingsley, Eric R. James, Mei-Chun Chen, Yonas Abebe, Natasha KC, Sumana Chakravarty, David Dolberg, Sara A. Healy, Halimatou Diawara, Mahamadou S. Sissoko, Issaka Sagara, David M. Cook, Judith E. Epstein, Benjamin Mordmüller, Melissa Kapulu, Andrea Kreidenweiss, Blandine Franke-Fayard, Selidji T. Agnandji, María-Silvia A. López Mikue, Matthew B.B. McCall, Laura Steinhardt, Martina Oneko, Ally Olotu, Ashley M. Vaughan, James G. Kublin, Sean C. Murphy, Said Jongo, Marcel Tanner, Sodiomon B. Sirima, Matthew B. Laurens, Claudia Daubenberger, Joana C. Silva, Kirsten E. Lyke, Chris J. Janse, Meta Roestenberg, Robert W. Sauerwein, Salim Abdulla, Alassane Dicko, Stefan H. I. Kappe, B. Kim Lee Sim, Patrick E. Duffy, Peter G. Kremsner, and Stephen L. Hoffman
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sporozoites ,vaccines ,pfspz ,pfspz vaccine ,pfspz-cvac ,pfspz-larc2 vaccine ,malaria vaccines ,live attenuated vaccines ,review ,direct venous inoculation ,Internal medicine ,RC31-1245 - Abstract
Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly effective vaccine is urgently needed, especially for Plasmodium falciparum (Pf), the deadliest human malaria parasite. Areas covered Sporozoites (SPZ), the parasite stage transmitted by Anopheles mosquitoes to humans, are the only vaccine immunogen achieving > 90% efficacy against Pf infection. This review describes > 30 clinical trials of PfSPZ vaccines in the U.S.A., Europe, Africa, and Asia, based on first-hand knowledge of the trials and PubMed searches of ‘sporozoites,’ ‘malaria,’ and ‘vaccines.’ Expert opinion First generation (radiation-attenuated) PfSPZ vaccines are safe, well tolerated, 80-100% efficacious against homologous controlled human malaria infection (CHMI) and provide 18-19 months protection without boosting in Africa. Second generation chemo-attenuated PfSPZ are more potent, 100% efficacious against stringent heterologous (variant strain) CHMI, but require a co-administered drug, raising safety concerns. Third generation, late liver stage-arresting, replication competent (LARC), genetically-attenuated PfSPZ are expected to be both safe and highly efficacious. Overall, PfSPZ vaccines meet safety, tolerability, and efficacy requirements for protecting pregnant women and travelers, with licensure for these populations possible within five years. Protecting children and mass vaccination programs to block transmission and eliminate malaria are long-term objectives.
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- 2023
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36. Immigrants’ health empowerment and access to health coverage in France: A stepped wedge randomised controlled trial
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Desgrées du Loû, Annabel, Derche, Nicolas, Gubert, Flore, Mbiribindi, Romain, Melchior, Maria, principal coordinators, Andrianirina, Ny Sata, Bousmah, Marwân-al-Qays, Carillon, Séverine, Comblon, Virginie, Coulibaly, Karna, Delbe, Angèle, Ebongue, Jacques, Notemi, Ruth Foundje, Gaywahali, Charles, Gosselin, Anne, Kohou, Veroska, Lert, France, Lusilu-Voza, Jean, Lutonadio, Belinda, Nyemeck, Yves, Mbiribindi, Patricia, Miatti, Thierry, Ngueya, Jean-Paul, Ravalihasy, Andrainolo, Ridde, Valéry, Senne, Jean-Noël, Sissoko, Oumar, Taéron, Corinne, Tess, Faya, and Zoumenou, Iris
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- 2023
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37. Socio-cultural representation of epilepsy at the teaching hospital of point G, Mali
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Coulibaly, Th, Dicko, O.A., Sangaré, M., Sissoko, A.S., Cissé, L., Landouré, G., Djimdé, S.O., Yalcouyé, A., Coulibaly, T., Karambé, M., Maiga, Y.M., and Guinto, C.O.
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- 2023
- Full Text
- View/download PDF
38. Malaria transmission-blocking vaccines Pfs230D1-EPA and Pfs25-EPA in Alhydrogel in healthy Malian adults; a phase 1, randomised, controlled trial
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Sagara, Issaka, Healy, Sara A, Assadou, Mahamadoun H, Kone, Mamady, Swihart, Bruce J, Kwan, Jennifer L, Fintzi, Jonathan, Sissoko, Kourane, Kamate, Bourama, Samake, Yacouba, Guindo, Merepen A, Doucoure, M'Bouye, Niaré, Karamoko, Dolo, Amagana, Diarra, Balla, Rausch, Kelly M, Narum, David L, Jones, David S, MacDonald, Nicholas J, Zhu, Daming, Gorres, J Patrick, Imeru, Alemush, Mohan, Rathy, Thera, Ismaila, Zaidi, Irfan, Salazar-Miralles, Fernando, Duan, Junhui, Neal, Jillian, Morrison, Robert D, Muratova, Olga, Sylla, Daman, O'Connell, Elise M, Wu, Yimin, Hume, Jen C C, Coulibaly, Mamadou B, Anderson, Charles F, Traore, Sekou F, Doumbo, Ogobara K, and Duffy, Patrick E
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- 2023
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39. Provider adherence to clinical care recommendations for infants and children who died in seven low- and middle-income countries in the Child Health and Mortality Prevention Surveillance (CHAMPS) network
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Solomon, Fatima, Sorour, Gillian, Lombaard, Hennie, Wadula, Jeannette, Petersen, Karen, Hale, Martin, Govender, Nelesh P., Swart, Peter J., Lala, Sanjay G., Velaphi, Sithembiso, Chawana, Richard, Adam, Yasmin, Wise, Amy, Fritz, Ashleigh, Myburgh, Nellie, Ndagurwa, Pedzisai, Hwinya, Cleopas, Bari, Sanwarul, Parveen, Shahana, Kamal, Mohammed, Uddin Ahmed, A.S.M. Nawshad, Hoque, Mahbubul, Tasnim, Saria, Islam, Ferdousi, Ariuman, Farida, Rahman, Mohammad Mosiur, Begum, Ferdousi, Zaman, K., Rahman, Mustafizur, Ahmed, Dilruba, Flora, Meerjady Sabrina, Shirin, Tahmina, Rahman, Mahbubur, Oundo, Joseph, Ibrahim, Alexander M., Temesgen, Fikremelekot, Gure, Tadesse, Alemu, Addisu, Yeshi, Melisachew Mulatu, Gizaw, Mahlet Abayneh, Orlien, Stian, Ali, Solomon, Otieno, Peter, Onyango, Peter Nyamthimba, Agaya, Janet, Oliech, Richard, Were, Joyce Akinyi, Gethi, Dickson, Khagayi, Sammy, Aol, George, Misore, Thomas, Owuor, Harun, Mugah, Christopher, Oluoch, Bernard, Ochola, Christine, Tennant, Sharon M., Greene, Carol L., Mehta, Ashka, Johnson, J. Kristie, Gaume, Brigitte, Koka, Rima, Fairchild, Karen D., Kone, Diakaridia, Sanogo, Doh, Onwuchekwa, Uma U., Kourouma, Nana, Sissoko, Seydou, Traore, Cheick Bougadari, Juma, Jane, Diarra, Kounandji, Traore, Awa, Diarra, Tiéman, Chawla, Kiranpreet, Nhampossa, Tacilta, Manhique, Zara, Mocumbi, Sibone, Menéndez, Clara, Munguambe, Khátia, Nhacolo, Ariel, Maixenchs, Maria, Moseray, Andrew, Tarawally, Fatmata Bintu, Seppeh, Martin, Mash, Ronald, Ojulong, Julius, Duduyemi, Babatunde, Bunn, James, Swaray-Deen, Alim, Bangura, Joseph, Jambai, Amara, Mannah, Margaret, Ita, Okokon, Chukwuegbo, Cornell, Sannoh, Sulaiman, Nwajiobi, Princewill, Kowuor, Dickens, Kaluma, Erick, Balogun, Oluseyi, Samura, Solomon, Pratt, Samuel, Moses, Francis, Sesay, Tom, Squire, James, Sesay, Joseph Kamanda, Kaykay, Osman, Halu, Binyam, Legesse, Hailemariam, Smart, Francis, Kenneh, Sartie, Ameh, Soter, Ritter, Jana, Wilson, Tais, Winchell, Jonas, Witherbee, Jakob, Salzberg, Navit T., Koplan, Jeffrey P., Basket, Margaret, Wadhwa, Ashutosh, Lee, Kyu Han, Wanga, Valentine, Martines, Roosecelis, Warang, Shamta, Diaz, Maureen, Waller, Jessica, Nair, Shailesh, Liu, Lucy, Bursuc, Courtney, LaHatte, Kristin, Raymer, Sarah, Blevins, John, Argeseanu, Solveig, Vyas, Kurt, Bhandari, Manu, Rees, Chris A., Igunza, Kitiezo Aggrey, Madewell, Zachary J., Akelo, Victor, Onyango, Dickens, El Arifeen, Shams, Gurley, Emily S., Hossain, Mohammad Zahid, Rahman, Afruna, Alam, Muntasir, Scott, J. Anthony G., Assefa, Nega, Madrid, Lola, Belachew, Anteneh, Leulseged, Haleluya, Kotloff, Karen L., Sow, Samba O., Tapia, Milagritos D., Keita, Adama Mamby, Sidibe, Diakaridia, Sitoe, Antonio, Varo, Rosauro, Ajanovic, Sara, Bassat, Quique, Mandomando, Inácio, Tippett Barr, Beth A., Ogbuanu, Ikechukwu, Cain, Carrie Jo, Bassey, Ima-Abasi, Luke, Ronita, Gassama, Khadija, Madhi, Shabir, Dangor, Ziyaad, Mahtab, Sana, du Toit, Jeanie, Mutevedzi, Portia C., Blau, Dianna M., Breiman, Robert F., and Whitney, Cynthia G.
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- 2023
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40. Neural tube defects as a cause of death among stillbirths, infants, and children younger than 5 years in sub-Saharan Africa and southeast Asia: an analysis of the CHAMPS network
- Author
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Nawshad Uddin Ahmed, A.S.M., Hoque, Mahbubul, Kamal, Mohammed, Mosiur, Mohammad, Begum, Ferdousi, Tasnim, Saria, Flora, Meerjady Sabrina, Arjuman, Farida, Khan, Iqbal Ansary, Shirin, Tahmina, Rahman, Mahbubur, Bari, Sanwarul, Parveen, Shahana, Islam, Farzana, Hossain, Mohammad Zahid, Islam, Kazi Munisul, Ahmed, Mohammad Sabbir, Zaman, K, Rahman, Mustafizur, Ahmed, Dilruba, Chowdhury, Md Atique Iqbal, Alam, Muntasir, Lee, Kyu Han, Islam, Ferdousi, Oundo, Joseph O, Temesgen, Fikremelekot, Yeshi, Melisachew Mulatu, Ibrahim, Alexander M, Gure, Tadesse, Edris, Yunus, Alemu, Addisu, Marami, Dadi, Lemma, Ephrem, Mekonnen, Ayantu, Wale, Henok, Tesfaye, Tseyon, Leulseged, Haleluya, Dufera, Tadesse, Belachew, Anteneh, Getnet, Fentabil, Fentaw, Surafel, Acham, Yenework, Orlien, Stian MS, Abayneh Gizaw, Mahlet, Rogena, Emily, Murila, Florence, Revathi, Gunturu, Mitei, Paul K, Kuria, Magdalene, Verani, Jennifer R, Igunza, Aggrey, Nyamthimba, Peter, Oele, Elizabeth, Fairchild, Karen D, Greene, Carol L, Koka, Rima, Mehta, Ashka, Tennant, Sharon M, Johnson, J Kristie, Keita, Tatiana, Keita, Adama Mamby, Kourouma, Nana, Onwuchekwa, Uma U, Traore, Awa, Sanogo, Doh, Sidibe, Diakaridia, Sissoko, Seydou, Kone, Diakaridia, Kindcardett, Milton, Munguambe, Khátia, Nhacolo, Ariel, Nhampossa, Tacilta, Vitorino, Pio, Xerinda, Elisio, Bramugy, Justina, Monjane, Celso, Nhachungue, Sheila, Hurtado, Juan Carlos, Maixenchs, Maria, Menéndez, Clara, Ordi, Jaume, Rakislova, Natalia, Valente, Marta, Manhique, Zara, Chitungo, Dercio, Mocumbi, Sibone, Carrilho, Carla, Fernandes, Fabiola, Pass Philipsborn, Rebecca, Koplan, Jeffrey P, Garel, Mischka, Dewey, Betsy, Nair, Shailesh, Salzberg, Navit T, Liu, Lucy, Alkis-Ramirez, Rebecca, Ritter, Jana M, Zaki, Sherif R, Gary, Joy, Winchell, Jonas M, Witherbee, Jacob, Waller, Jessica L, Fayorsey, Ruby, Luke, Ronita, Bassey, Ima-Abasi, Kowuor, Dickens, Sesay, Foday, Kosia, Baindu, Pratt, Samuel, Cain, Carrie-Jo, Samura, Solomon, Solomon, Fatima, Fritz, Ashleigh, Dludlu, Noluthando, Ntuli, Constance, Chawana, Richard, Petersen, Karen, Lala, Sanjay G, Velaphi, Sithembiso, Wadula, Jeannette, Hale, Martin, Swart, Peter J, Lombaard, Hennie, Moosa, Rahima, Sorour, Gillian, Madrid, Lola, Vyas, Kartavya J, Kancherla, Vijaya, Suchdev, Parminder S, Bassat, Quique, Sow, Samba O, El Arifeen, Shams, Madhi, Shabir A, Onyango, Dickens, Ogbuanu, Ikechukwu, Scott, J Anthony G, Blau, Dianna, Mandomando, Inacio, Keita, Adama M, Gurley, Emily S, Mahtab, Sana, Akelo, Victor, Sannoh, Sulaiman, Tilahun, Yenenesh, Varo, Rosauro, Onwuchekwa, Uma, Rahman, Afruna, Adam, Yasmin, Omore, Richard, Lako, Sandra, Wise, Amy, Tippet-Barr, Beth A, Kaluma, Erick, Ajanovic, Sara, Kotloff, Karen L, Mutevedzi, Portia, Tapia, Milagritos D, Moses, Francis, Whitney, Cynthia G, and Assefa, Nega
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- 2023
- Full Text
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41. Safety and efficacy of a three-dose regimen of Plasmodium falciparum sporozoite vaccine in adults during an intense malaria transmission season in Mali: a randomised, controlled phase 1 trial
- Author
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Sissoko, Mahamadou S, Healy, Sara A, Katile, Abdoulaye, Zaidi, Irfan, Hu, Zonghui, Kamate, Bourama, Samake, Yacouba, Sissoko, Kourane, Mwakingwe-Omari, Agnes, Lane, Jacquelyn, Imeru, Alemush, Mohan, Rathy, Thera, Ismaila, Guindo, Cheick Oumar, Dolo, Amagana, Niare, Karamoko, Koïta, Fanta, Niangaly, Amadou, Rausch, Kelly M, Zeguime, Amatigue, Guindo, Merepen A, Bah, Aissatou, Abebe, Yonas, James, Eric R, Manoj, Anita, Murshedkar, Tooba, KC, Natasha, Sim, B Kim Lee, Billingsley, Peter F, Richie, Thomas L, Hoffman, Stephen L, Doumbo, Ogobara, and Duffy, Patrick E
- Published
- 2022
- Full Text
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42. Père Josef Stamer: Itinéraire d'un connaisseur de l'islam et d'un ami des musulmans
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Etienne Fakaba Sissoko and Etienne Fakaba Sissoko
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- 2023
43. Des auxiliaires Ançar de Médine, aux Ançar Dine de Ousmane Cherif Madani Haidara au Mali : Doctrine et liens historiques
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Etienne Fakaba Sissoko and Etienne Fakaba Sissoko
- Published
- 2023
44. Propagande, Agitation, Harcèlement : La communication gouvernementale pendant la transition au Mali
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Etienne Fakaba Sissoko and Etienne Fakaba Sissoko
- Published
- 2023
45. Si j'étais Président de la République du Mali...: Laissez-nous choisir nos Présidents
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Ahmed Bamba Famoussa Sissoko and Ahmed Bamba Famoussa Sissoko
- Published
- 2023
46. Mali, les obstacles sociopolitiques à la décentralisation (1991-2021): Panorama d'une réforme ambitieuse
- Author
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M'baha moussa Sissoko and M'baha moussa Sissoko
- Published
- 2023
47. L'efficacité économique de la gouvernance de l'État par le droit en Afrique francophone
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Mariam Maiga, Diomansy I. Sissoko and Mariam Maiga, Diomansy I. Sissoko
- Published
- 2023
48. Provider adherence to clinical care recommendations for infants and children who died in seven low- and middle-income countries in the Child Health and Mortality Prevention Surveillance (CHAMPS) networkResearch in context
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Chris A. Rees, Kitiezo Aggrey Igunza, Zachary J. Madewell, Victor Akelo, Dickens Onyango, Shams El Arifeen, Emily S. Gurley, Mohammad Zahid Hossain, Afruna Rahman, Muntasir Alam, J. Anthony G. Scott, Nega Assefa, Lola Madrid, Anteneh Belachew, Haleluya Leulseged, Karen L. Kotloff, Samba O. Sow, Milagritos D. Tapia, Adama Mamby Keita, Diakaridia Sidibe, Antonio Sitoe, Rosauro Varo, Sara Ajanovic, Quique Bassat, Inácio Mandomando, Beth A. Tippett Barr, Ikechukwu Ogbuanu, Carrie Jo Cain, Ima-Abasi Bassey, Ronita Luke, Khadija Gassama, Shabir Madhi, Ziyaad Dangor, Sana Mahtab, Sithembiso Velaphi, Jeanie du Toit, Portia C. Mutevedzi, Dianna M. Blau, Robert F. Breiman, Cynthia G. Whitney, Fatima Solomon, Gillian Sorour, Hennie Lombaard, Jeannette Wadula, Karen Petersen, Martin Hale, Nelesh P. Govender, Peter J. Swart, Sanjay G. Lala, Richard Chawana, Yasmin Adam, Amy Wise, Ashleigh Fritz, Nellie Myburgh, Pedzisai Ndagurwa, Cleopas Hwinya, Sanwarul Bari, Shahana Parveen, Mohammed Kamal, A.S.M. Nawshad Uddin Ahmed, Mahbubul Hoque, Saria Tasnim, Ferdousi Islam, Farida Ariuman, Mohammad Mosiur Rahman, Ferdousi Begum, K. Zaman, Mustafizur Rahman, Dilruba Ahmed, Meerjady Sabrina Flora, Tahmina Shirin, Mahbubur Rahman, Joseph Oundo, Alexander M. Ibrahim, Fikremelekot Temesgen, Tadesse Gure, Addisu Alemu, Melisachew Mulatu Yeshi, Mahlet Abayneh Gizaw, Stian Orlien, Solomon Ali, Peter Otieno, Peter Nyamthimba Onyango, Janet Agaya, Richard Oliech, Joyce Akinyi Were, Dickson Gethi, Sammy Khagayi, George Aol, Thomas Misore, Harun Owuor, Christopher Mugah, Bernard Oluoch, Christine Ochola, Sharon M. Tennant, Carol L. Greene, Ashka Mehta, J. Kristie Johnson, Brigitte Gaume, Rima Koka, Karen D. Fairchild, Diakaridia Kone, Doh Sanogo, Uma U. Onwuchekwa, Nana Kourouma, Seydou Sissoko, Cheick Bougadari Traore, Jane Juma, Kounandji Diarra, Awa Traore, Tiéman Diarra, Kiranpreet Chawla, Tacilta Nhampossa, Zara Manhique, Sibone Mocumbi, Clara Menéndez, Khátia Munguambe, Ariel Nhacolo, Maria Maixenchs, Andrew Moseray, Fatmata Bintu Tarawally, Martin Seppeh, Ronald Mash, Julius Ojulong, Babatunde Duduyemi, James Bunn, Alim Swaray-Deen, Joseph Bangura, Amara Jambai, Margaret Mannah, Okokon Ita, Cornell Chukwuegbo, Sulaiman Sannoh, Princewill Nwajiobi, Dickens Kowuor, Erick Kaluma, Oluseyi Balogun, Solomon Samura, Samuel Pratt, Francis Moses, Tom Sesay, James Squire, Joseph Kamanda Sesay, Osman Kaykay, Binyam Halu, Hailemariam Legesse, Francis Smart, Sartie Kenneh, Soter Ameh, Jana Ritter, Tais Wilson, Jonas Winchell, Jakob Witherbee, Navit T. Salzberg, Jeffrey P. Koplan, Margaret Basket, Ashutosh Wadhwa, Kyu Han Lee, Valentine Wanga, Roosecelis Martines, Shamta Warang, Maureen Diaz, Jessica Waller, Shailesh Nair, Lucy Liu, Courtney Bursuc, Kristin LaHatte, Sarah Raymer, John Blevins, Solveig Argeseanu, Kurt Vyas, and Manu Bhandari
- Subjects
Childhood ,Mortality ,Clinical care ,Guideline adherence ,Medicine (General) ,R5-920 - Abstract
Summary: Background: Most childhood deaths globally are considered preventable through high-quality clinical care, which includes adherence to clinical care recommendations. Our objective was to describe adherence to World Health Organization recommendations for the management of leading causes of death among children. Methods: We conducted a retrospective, descriptive study examining clinical data for children aged 1–59 months who were hospitalized and died in a Child Health and Mortality Prevention Surveillance (CHAMPS) catchment, December 2016–June 2021. Catchment areas included: Baliakandi and Faridpur, Bangladesh; Kersa, Haramaya, and Harar, Ethiopia; Kisumu and Siaya, Kenya; Bamako, Mali; Manhiça and Quelimane, Mozambique; Makeni, Sierra Leone; Soweto, South Africa. We reviewed medical records of those who died from lower respiratory tract infections, sepsis, malnutrition, malaria, and diarrheal diseases to determine the proportion who received recommended treatments and compared adherence by hospitalization duration. Findings: CHAMPS enrolled 460 hospitalized children who died from the leading causes (median age 12 months, 53.0% male). Median hospital admission was 31 h. There were 51.0% (n = 127/249) of children who died from lower respiratory tract infections received supplemental oxygen. Administration of intravenous fluids for sepsis (15.9%, n = 36/226) and supplemental feeds for malnutrition (14.0%, n = 18/129) were uncommon. There were 51.4% (n = 55/107) of those who died from malaria received antimalarials. Of the 80 children who died from diarrheal diseases, 76.2% received intravenous fluids. Those admitted for ≥24 h more commonly received antibiotics for lower respiratory tract infections and sepsis, supplemental feeds for malnutrition, and intravenous fluids for sepsis than those admitted
- Published
- 2023
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49. Stratigraphy and paleobiology of the Upper Cretaceous-Lower Paleogene sediments from the Trans-Saharan Seaway in Mali /
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O'Leary, Maureen A., Bouaré, Mohamed L., Claeson, Kerin M., Heilbronn, Kelly, Hill, Robert V., McCartney, Jacob A., Sessa, Jocelyn A., Sissoko, Famory, Tapanila, Leif, Wheeler, E. A., Roberts, Eric M., American Museum of Natural History Library, O'Leary, Maureen A., Bouaré, Mohamed L., Claeson, Kerin M., Heilbronn, Kelly, Hill, Robert V., McCartney, Jacob A., Sessa, Jocelyn A., Sissoko, Famory, Tapanila, Leif, Wheeler, E. A., and Roberts, Eric M.
- Subjects
Cretaceous ,Cretaceous-Paleogene boundary ,Geology ,Geology, Stratigraphic ,Mali ,Paleobiology ,Paleoecology ,Paleogene ,Paleontology ,Paleontology, Stratigraphic ,Stratigraphic correlation - Published
- 2019
50. Lack of Association of C677T Methylenetetrahydrofolate Reductase Polymorphism with Breast Cancer Risk in Mali
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Brehima Diakite, Yaya Kassogue, Mamoudou Maiga, Guimogo Dolo, Oumar Kassogue, Jane L. Holl, Brian Joyce, Jun Wang, Kadidiatou Cisse, Fousseyni Diarra, Mamadou L. Keita, Cheick B. Traore, Bakarou Kamate, Sidi B. Sissoko, Bourama Coulibaly, Adama S. Sissoko, Drissa Traore, Fatoumata M. Sidibe, Sekou Bah, Ibrahim Teguete, Madani Ly, Sellama Nadifi, Hind Dehbi, Kyeezu Kim, Robert Murphy, and Lifang Hou
- Subjects
Genetics ,QH426-470 - Abstract
Methylenetetrahydrofolate reductase (MTHFR) plays a major role in the metabolism of folates and homocysteine, which in turn can affect gene expression and ultimately promote the development of breast cancer. Thus, mutations in the MTHFR gene could influence homocysteine, methionine, and S-adenosylmethionine levels and, indirectly, nucleotide levels. Imbalance in methionine and S-adenosylmethionine synthesis affects protein synthesis and methylation. These changes, which affect gene expression, may ultimately promote the development of breast cancer. We therefore hypothesized that such mutations could also play an important role in the occurrence and pathogenesis of breast cancer in a Malian population. In this study, we used the PCR-RFLP technique to identify the different genotypic profiles of the C677T MTHFR polymorphism in 127 breast cancer women and 160 healthy controls. The genotypic distribution of the C677T polymorphism in breast cancer cases was 88.2% for CC, 11.0% for CT, and 0.8% for TT. Healthy controls showed a similar distribution with 90.6% for CC, 8.8% for CT, and 0.6% for TT. We found no statistical association between the C677T polymorphism and breast cancer risk for the codominant models CT and TT p>0.05. The same trend was observed when the analysis was extended to other genetic models, including dominant (p = 0.50), recessive (p = 0.87), and additive (p = 0.50) models. The C677T polymorphism of MTHFR gene did not influence the risk of breast cancer in the Malian samples.
- Published
- 2023
- Full Text
- View/download PDF
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