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446 results on '"Saunamäki, Kari"'

1. The importance of nonobstructive plaque characteristics in symptomatic and asymptomatic coronary artery disease

Author

Kofoed, Klaus F., Nordestgaard, Børge, Køber, Lars V., Kühl, J. Tobias, Fuchs, Andreas, Sigvardsen, Per E., Sørgaard, Mathias, de Knegt, Martina C., Norsk, Jakob, Frestad, Daria, Mejdahl, Mads, Elming, Marie, Sørensen, Samuel Kiil, Hindsøe, Louise, Thomsen, Anna Foged, Udholm, Patricia Martens, Pihl, Christian, Nilsson, Julia, Byrne, Christina, Knudsen, Andreas Dehlbæk, Haugen, Morten, Windfeld-Mathiasen, Josefine, Laura Wiegandt, Yaffah Tamar, Pham, Michael H.C., Ballegaard, Christian, Arnaa, Kirsten, Møller, Christina, Thrysøe, Kirsten, Linde, Jesper J., Hove, Jens D., Jensen, Gorm B., Kelbæk, Henning, Nielsen, Walter, Trysøe, Kirsten, Bock-Pedersen, Tina, Hansen, Bettina, Kløvgaard, Lene, Holmvang, Lene, Engstrøm, Thomas, Helquist, Steffen, Jørgensen, Erik, Petersen, Frans, Saunamaki, Kari, Clemmensen, Peter, Høfsten, Dan E., Sadjadieh, Golnaz, Laursen, Peter Nørkjær, Petersen, Christian Torp, Hansen, Peter Riis, Gislason, Gunnar, Abildgaard, Ulrik, Jensen, Jan Skov, Galatius, Søren, Fritz-Hansen, Thomas, Bech, Jan, Wachtell, Christian, Madsen, Jan Kyst, Smedegaard, Lærke, Özcan, Cengiz, Heitmann, Merete, Svendsen, Ida Hastrup, Nielsen, Olav Wendelboe, Kristiansen, Ole, Bjerre, Andreas Fabricius, Dixen, Ulrik, Madsen, Johnny Koertz, Fornitz, Gitte Gleerup, Raymond, Ilan, Abdulla, Jawdat, Lyngbæk, Stig, Steffensen, Rolf, Jurlander, Birgit, Kragelund, Charlotte, Dominguez, Helena, Schou, Morten, Elming, Hanne, Therkelsen, Susette, Jensen, Andreas K., Hansen, Peter R., and Nordestgaard, Børge G.

Published
2024
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2. Long-term safety and feasibility of three-vessel multimodality intravascular imaging in patients with ST-elevation myocardial infarction: the IBIS-4 (integrated biomarker and imaging study) substudy

Author

Taniwaki, Masanori, Radu, Maria D., Garcia-Garcia, Hector M., Heg, Dik, Kelbæk, Henning, Holmvang, Lene, Moschovitis, Aris, Noble, Stephane, Pedrazzini, Giovanni, Saunamäki, Kari, Dijkstra, Jouke, Landmesser, Ulf, Wenaweser, Peter, Meier, Bernhard, Stefanini, Giulio G., Roffi, Marco, Lüscher, Thomas F., Windecker, Stephan, and Räber, Lorenz

Published
2015
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6. Prognostic Value of Coronary CT Angiography in Patients With Non–ST-Segment Elevation Acute Coronary Syndromes

Author

Kofoed, Klaus F., Engstrøm, Thomas, Sigvardsen, Per E., Linde, Jesper J., Torp-Pedersen, Christian, de Knegt, Martina, Hansen, Peter R., Fritz-Hansen, Thomas, Bech, Jan, Heitmann, Merete, Nielsen, Olav W., Høfsten, Dan, Kühl, Jørgen T., Raymond, Ilan E., Kristiansen, Ole P., Svendsen, Ida H., Domínguez Vall-Lamora, M. H., Kragelund, Charlotte, Hove, Jens D., Jørgensen, Tem, Fornitz, Gitte G., Steffensen, Rolf, Jurlander, Birgit, Abdulla, Jawdat, Lyngbæk, Stig, Elming, Hanne, Therkelsen, Susette K., Jørgensen, Erik, Kløvgaard, Lene, Bang, Lia E., Helqvist, Steffen, Galatius, Søren, Pedersen, Frants, Abildgaard, Ulrik, Clemmensen, Peter, Saunamäki, Kari, Holmvang, Lene, Gislason, Gunnar, Kelbæk, Henning, Køber, Lars V., Kofoed, Klaus F., Engstrøm, Thomas, Sigvardsen, Per E., Linde, Jesper J., Torp-Pedersen, Christian, de Knegt, Martina, Hansen, Peter R., Fritz-Hansen, Thomas, Bech, Jan, Heitmann, Merete, Nielsen, Olav W., Høfsten, Dan, Kühl, Jørgen T., Raymond, Ilan E., Kristiansen, Ole P., Svendsen, Ida H., Domínguez Vall-Lamora, M. H., Kragelund, Charlotte, Hove, Jens D., Jørgensen, Tem, Fornitz, Gitte G., Steffensen, Rolf, Jurlander, Birgit, Abdulla, Jawdat, Lyngbæk, Stig, Elming, Hanne, Therkelsen, Susette K., Jørgensen, Erik, Kløvgaard, Lene, Bang, Lia E., Helqvist, Steffen, Galatius, Søren, Pedersen, Frants, Abildgaard, Ulrik, Clemmensen, Peter, Saunamäki, Kari, Holmvang, Lene, Gislason, Gunnar, Kelbæk, Henning, and Køber, Lars V.

Abstract

Background: Severity and extent of coronary artery disease (CAD) assessed by invasive coronary angiography (ICA) guide treatment and may predict clinical outcome in patients with non–ST-segment elevation acute coronary syndrome (NSTEACS). Objectives: This study tested the hypothesis that coronary computed tomography angiography (CTA) is equivalent to ICA for risk assessment in patients with NSTEACS. Methods: The VERDICT (Very Early Versus Deferred Invasive Evaluation Using Computerized Tomography in Patients With Acute Coronary Syndromes) trial evaluated timing of treatment in relation to outcome in patients with NSTEACS and included a clinically blinded coronary CTA conducted prior to ICA. Severity of CAD was defined as obstructive (coronary stenosis ≥50%) or nonobstructive. Extent of CAD was defined as high risk (obstructive left main or proximal left anterior descending artery stenosis and/or multivessel disease) or non–high risk. The primary endpoint was a composite of all-cause death, nonfatal recurrent myocardial infarction, hospital admission for refractory myocardial ischemia, or heart failure. Results: Coronary CTA and ICA were conducted in 978 patients. During a median follow-up time of 4.2 years (interquartile range: 2.7 to 5.5 years), the primary endpoint occurred in 208 patients (21.3%). The rate of the primary endpoint was up to 1.7-fold higher in patients with obstructive CAD compared with in patients with nonobstructive CAD as defined by coronary CTA (hazard ratio [HR]: 1.74; 95% confidence interval [CI]: 1.22 to 2.49; p = 0.002) or ICA (HR: 1.54; 95% CI: 1.13 to 2.11; p = 0.007). In patients with high-risk CAD, the rate of the primary endpoint was 1.5-fold higher compared with the rate in those with non–high-risk CAD as defined by coronary CTA (HR: 1.56; 95% CI: 1.18 to 2.07; p = 0.002). A similar trend was noted for ICA (HR: 1.28; 95% CI: 0.98 to 1.69; p = 0.07). Conclusions: Coronary CTA is equivalent to ICA for the assessment of long-term risk

Published
2021

7. Long-term safety and feasibility of three-vessel multimodality intravascular imaging in patients with ST-elevation myocardial infarction: the IBIS-4 (integrated biomarker and imaging study) substudy

Author

Taniwaki, Masanori, Radu, Maria, Garcia-Garcia, Hector, Heg, Dik, Kelbæk, Henning, Holmvang, Lene, Moschovitis, Aris, Noble, Stephane, Pedrazzini, Giovanni, Saunamäki, Kari, Dijkstra, Jouke, Landmesser, Ulf, Wenaweser, Peter, Meier, Bernhard, Stefanini, Giulio, Roffi, Marco, Lüscher, Thomas, Windecker, Stephan, Räber, Lorenz, Taniwaki, Masanori, Radu, Maria, Garcia-Garcia, Hector, Heg, Dik, Kelbæk, Henning, Holmvang, Lene, Moschovitis, Aris, Noble, Stephane, Pedrazzini, Giovanni, Saunamäki, Kari, Dijkstra, Jouke, Landmesser, Ulf, Wenaweser, Peter, Meier, Bernhard, Stefanini, Giulio, Roffi, Marco, Lüscher, Thomas, Windecker, Stephan, and Räber, Lorenz

Abstract

We assessed the feasibility and the procedural and long-term safety of intracoronary (i.c) imaging for documentary purposes with optical coherence tomography (OCT) and intravascular ultrasound (IVUS) in patients with acute ST-elevation myocardial infarction (STEMI) undergoing primary PCI in the setting of IBIS-4 study. IBIS4 (NCT00962416) is a prospective cohort study conducted at five European centers including 103 STEMI patients who underwent serial three-vessel coronary imaging during primary PCI and at 13months. The feasibility parameter was successful imaging, defined as the number of pullbacks suitable for analysis. Safety parameters included the frequency of peri-procedural complications, and major adverse cardiac events (MACE), a composite of cardiac death, myocardial infarction (MI) and any clinically-indicated revascularization at 2years. Clinical outcomes were compared with the results from a cohort of 485 STEMI patients undergoing primary PCI without additional imaging. Imaging of the infarct-related artery at baseline (and follow-up) was successful in 92.2% (96.6%) of patients using OCT and in 93.2% (95.5%) using IVUS. Imaging of the non-infarct-related vessels was successful in 88.7% (95.6%) using OCT and in 90.5% (93.3%) using IVUS. Periprocedural complications occurred <2.0% of OCT and none during IVUS. There were no differences throughout 2years between the imaging and control group in terms of MACE (16.7 vs. 13.3%, adjusted HR1.40, 95% CI 0.77-2.52, p=0.27). Multi-modality three-vessel i.c. imaging in STEMI patients undergoing primary PCI is consistent a high degree of success and can be performed safely without impact on cardiovascular events at long-term follow-up.

Published
2021

9. Coronary evaginations are associated with positive vessel remodelling and are nearly absent following implantation of newer-generation drug-eluting stents: an optical coherence tomography and intravascular ultrasound study

Author

Radu, Maria D., Räber, Lorenz, Kalesan, Bindu, Muramatsu, Takashi, Kelbæk, Henning, Heo, Jungho, Jørgensen, Erik, Helqvist, Steffen, Farooq, Vasim, Brugaletta, Salvatore, Garcia-Garcia, Hector M., Jüni, Peter, Saunamäki, Kari, Windecker, Stephan, and Serruys, Patrick W.

Published
2014
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10. Identification of vulnerable plaques and patients by intracoronary near-infrared spectroscopy and ultrasound (PROSPECT II): a prospective natural history study

Author

Erlinge, David, primary, Maehara, Akiko, additional, Ben-Yehuda, Ori, additional, Bøtker, Hans Erik, additional, Maeng, Michael, additional, Kjøller-Hansen, Lars, additional, Engstrøm, Thomas, additional, Matsumura, Mitsuaki, additional, Crowley, Aaron, additional, Dressler, Ovidiu, additional, Mintz, Gary S, additional, Fröbert, Ole, additional, Persson, Jonas, additional, Wiseth, Rune, additional, Larsen, Alf Inge, additional, Okkels Jensen, Lisette, additional, Nordrehaug, Jan Erik, additional, Bleie, Øyvind, additional, Omerovic, Elmir, additional, Held, Claes, additional, James, Stefan K, additional, Ali, Ziad A, additional, Muller, James E, additional, Stone, Gregg W, additional, Ahlehoff, Ole, additional, Amin, Azad, additional, Angerås, Oskar, additional, Appikonda, Praveen, additional, Balachandran, Saranya, additional, Barvik, Ståle, additional, Bendix, Kristoffer, additional, Bertilsson, Maria, additional, Boden, Ulrika, additional, Bogale, Nigussie, additional, Bonarjee, Vernon, additional, Calais, Fredrik, additional, Carlsson, Jörg, additional, Carstensen, Steen, additional, Christersson, Christina, additional, Christiansen, Evald Høj, additional, Corral, Maria, additional, De Backer, Ole, additional, Dhaha, Usama, additional, Dworeck, Christian, additional, Eggers, Kai, additional, Elfström, Charlotta, additional, Ellert, Julia, additional, Eriksen, Erlend, additional, Fallesen, Christian, additional, Forsman, Margareta, additional, Fransson, Helena, additional, Gaballa, Mohsen, additional, Gacki, Marek, additional, Götberg, Matthias, additional, Hagström, Lars, additional, Hallberg, Theresa, additional, Hambraeus, Kristina, additional, Haraldsson, Inger, additional, Harnek, Jan, additional, Havndrup, Ole, additional, Hegbom, Knut, additional, Heigert, Matthias, additional, Helqvist, Steffen, additional, Herstad, Jon, additional, Hijazi, Ziad, additional, Holmvang, Lene, additional, Ioanes, Dan, additional, Iqbal, Amjid, additional, Iversen, Allan, additional, Jacobson, Jaclyn, additional, Jakobsen, Lars, additional, Jankovic, Ivana, additional, Jensen, Ulf, additional, Jensevik, Karin, additional, Johnston, Nina, additional, Jonasson, Torfi Fjalar, additional, Jørgensen, Erik, additional, Joshi, Francis, additional, Kajermo, Ulf, additional, Kåver, Frida, additional, Kelbæk, Henning, additional, Kellerth, Thomas, additional, Kish, Mitra, additional, Koenig, Wolfgang, additional, Koul, Sasha, additional, Lagerqvist, Bo, additional, Larsson, Bertil, additional, Lassen, Jens Flensted, additional, Leiren, Olav, additional, Li, Zhe, additional, Lidell, Christer, additional, Linder, Rikard, additional, Lindstaedt, Michael, additional, Lindström, Gunilla, additional, Liu, Shen, additional, Løland, Kjetil Halvorsen, additional, Lønborg, Jacob, additional, Márton, László, additional, Mir-Akbari, Habib, additional, Mohamed, Shameema, additional, Odenstedt, Jacob, additional, Ogne, Christer, additional, Oldgren, Jonas, additional, Olivecrona, Göran, additional, Östlund-Papadogeorgos, Nikolas, additional, Ottesen, Michael, additional, Packer, Erik, additional, Palmquist, Åsa Michelgård, additional, Paracha, Quratulain, additional, Pedersen, Frans, additional, Petursson, Petur, additional, Råmunddal, Truls, additional, Rotevatn, Svein, additional, Sanchez, Raquel, additional, Sarno, Giovanna, additional, Saunamäki, Kari I, additional, Scherstén, Fredrik, additional, Serruys, Patrick W, additional, Sjögren, Iwar, additional, Sørensen, Rikke, additional, Srdanovic, Iva, additional, Subhani, Zuka, additional, Svensson, Eva, additional, Thuesen, Anne, additional, Tijssen, Jan, additional, Tilsted, Hans-Henrik, additional, Tödt, Tim, additional, Trovik, Thor, additional, Våga, Bjørn Inge, additional, Varenhorst, Christoph, additional, Veien, Karsten, additional, Vestman, Emma, additional, Völz, Sebastian, additional, Wallentin, Lars, additional, Wykrzykowska, Joanna, additional, Zagozdzon, Leszek, additional, Zamfir, Manuela, additional, Zedigh, Crister, additional, Zhong, Hang, additional, and Zhou, Zhipeng, additional

Published
2021
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11. Prognostic Value of Coronary CT Angiography in Patients With Non–ST-Segment Elevation Acute Coronary Syndromes

Author

Kofoed, Klaus F., primary, Engstrøm, Thomas, additional, Sigvardsen, Per E., additional, Linde, Jesper J., additional, Torp-Pedersen, Christian, additional, de Knegt, Martina, additional, Hansen, Peter R., additional, Fritz-Hansen, Thomas, additional, Bech, Jan, additional, Heitmann, Merete, additional, Nielsen, Olav W., additional, Høfsten, Dan, additional, Kühl, Jørgen T., additional, Raymond, Ilan E., additional, Kristiansen, Ole P., additional, Svendsen, Ida H., additional, Domínguez Vall-Lamora, M.H., additional, Kragelund, Charlotte, additional, Hove, Jens D., additional, Jørgensen, Tem, additional, Fornitz, Gitte G., additional, Steffensen, Rolf, additional, Jurlander, Birgit, additional, Abdulla, Jawdat, additional, Lyngbæk, Stig, additional, Elming, Hanne, additional, Therkelsen, Susette K., additional, Jørgensen, Erik, additional, Kløvgaard, Lene, additional, Bang, Lia E., additional, Helqvist, Steffen, additional, Galatius, Søren, additional, Pedersen, Frants, additional, Abildgaard, Ulrik, additional, Clemmensen, Peter, additional, Saunamäki, Kari, additional, Holmvang, Lene, additional, Gislason, Gunnar, additional, Kelbæk, Henning, additional, and Køber, Lars V., additional

Published
2021
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12. Soluble urokinase receptor as a predictor of non-cardiac mortality in patients with percutaneous coronary intervention treated ST-segment elevation myocardial infarction

Author

Sandø, Andreas, Schultz, Martin, Eugen-Olsen, Jesper, Køber, Lars, Engstrøm, Thomas, Kelbæk, Henning, Jørgensen, Erik, Saunamäki, Kari, Holmvang, Lene, Pedersen, Frants, Tilsted, Hans Henrik, Høfsten, Dan, Helqvist, Steffen, Clemmensen, Peter, Iversen, Kasper, Sandø, Andreas, Schultz, Martin, Eugen-Olsen, Jesper, Køber, Lars, Engstrøm, Thomas, Kelbæk, Henning, Jørgensen, Erik, Saunamäki, Kari, Holmvang, Lene, Pedersen, Frants, Tilsted, Hans Henrik, Høfsten, Dan, Helqvist, Steffen, Clemmensen, Peter, and Iversen, Kasper

Abstract

BACKGROUND: Identification of patients at high risk of non-cardiac mortality following ST-segment elevation myocardial infarction (STEMI) could guide clinicians to identify patients who require attention due to serious non-cardiac conditions after the acute phase of STEMI. The purpose of this study was to evaluate if the non-specific and prognostic biomarker of inflammation and comorbidity, soluble urokinase receptor (suPAR), could predict non-cardiac mortality in a cohort of STEMI patients.METHODS: SuPAR was measured in 1,190 STEMI patients who underwent primary percutaneous coronary intervention (pPCI). The primary endpoint was non-cardiac mortality, secondary endpoints were cardiac mortality, all-cause mortality, reinfarction and periprocedural acute kidney injury. Backwards elimination of potential confounders significantly associated with the respective outcome was used to adjust associations.RESULTS: Patients were followed for a median of 3.0 years (interquartile range 2.5- 3.6 years). Multivariate cox regression revealed that a plasma suPAR level above 3.70 ng mL-1 was associated with non-cardiac and cardiac mortality at hazard ratios 3.33 (95% confidence interval 1.67-6.63, p = 0.001, adjusted for age) and 0.99 (0.18-5.30, p = 0.98, adjusted for previous myocardial infarction and left ventricular ejection fraction), respectively.CONCLUSION: In patients with pPCI treated STEMI, suPAR was an independent prognostic biomarker of non-cardiac but not cardiac mortality and may identify patients with high risk of non-cardiac mortality.

Published
2020

13. Coronary CT Angiography in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome

Author

Linde, Jesper J, Kelbæk, Henning, Hansen, Thomas Fritz, Sigvardsen, Per E, Torp-Pedersen, Christian Tobias, Bech, Jan, Heitmann, Merete, Nielsen, Olav W, Høfsten, Dan, Kühl, Jørgen T, Raymond, Ilan E, Kristiansen, Ole P, Svendsen, Ida H, Vall-Lamora, Maria H D, Kragelund, Charlotte, de Knegt, Martina, Hove, Jens D, Jørgensen, Tem, Fornitz, Gitte G, Steffensen, Rolf, Jurlander, Birgit, Abdulla, Jawdat, Lyngbæk, Stig, Elming, Hanne, Therkelsen, Susette K, Jørgensen, Erik, Kløvgaard, Lene, Bang, Lia Evi, Hansen, Peter Riis, Helqvist, Steffen, Galatius, Søren, Pedersen, Frants, Abildgaard, Ulrik, Clemmensen, Peter, Saunamäki, Kari, Holmvang, Lene, Engstrøm, Thomas, Gislason, Gunnar, Køber, Lars V, Kofoed, Klaus F, Linde, Jesper J, Kelbæk, Henning, Hansen, Thomas Fritz, Sigvardsen, Per E, Torp-Pedersen, Christian Tobias, Bech, Jan, Heitmann, Merete, Nielsen, Olav W, Høfsten, Dan, Kühl, Jørgen T, Raymond, Ilan E, Kristiansen, Ole P, Svendsen, Ida H, Vall-Lamora, Maria H D, Kragelund, Charlotte, de Knegt, Martina, Hove, Jens D, Jørgensen, Tem, Fornitz, Gitte G, Steffensen, Rolf, Jurlander, Birgit, Abdulla, Jawdat, Lyngbæk, Stig, Elming, Hanne, Therkelsen, Susette K, Jørgensen, Erik, Kløvgaard, Lene, Bang, Lia Evi, Hansen, Peter Riis, Helqvist, Steffen, Galatius, Søren, Pedersen, Frants, Abildgaard, Ulrik, Clemmensen, Peter, Saunamäki, Kari, Holmvang, Lene, Engstrøm, Thomas, Gislason, Gunnar, Køber, Lars V, and Kofoed, Klaus F

Abstract

BACKGROUND: In patients with non-ST-segment elevation acute coronary syndrome (NSTEACS), coronary pathology may range from structurally normal vessels to severe coronary artery disease.OBJECTIVES: The purpose of this study was to test if coronary computed tomography angiography (CTA) may be used to exclude coronary artery stenosis ≥50% in patients with NSTEACS.METHODS: The VERDICT (Very Early Versus Deferred Invasive Evaluation Using Computerized Tomography in Patients With Acute Coronary Syndromes) trial (NCT02061891) evaluated the outcome of patients with confirmed NSTEACS randomized 1:1 to very early (within 12 h) or standard (48 to 72 h) invasive coronary angiography (ICA). As an observational component of the trial, a clinically blinded coronary CTA was conducted prior to ICA in both groups. The primary endpoint was the ability of coronary CTA to rule out coronary artery stenosis (≥50% stenosis) in the entire population, expressed as the negative predictive value (NPV), using ICA as the reference standard.RESULTS: Coronary CTA was conducted in 1,023 patients-very early, 2.5 h (interquartile range [IQR]: 1.8 to 4.2 h), n = 583; and standard, 59.9 h (IQR: 38.9 to 86.7 h); n = 440 after the diagnosis of NSTEACS was made. A coronary stenosis ≥50% was found by coronary CTA in 68.9% and by ICA in 67.4% of the patients. Per-patient NPV of coronary CTA was 90.9% (95% confidence interval [CI]: 86.8% to 94.1%) and the positive predictive value, sensitivity, and specificity were 87.9% (95% CI: 85.3% to 90.1%), 96.5% (95% CI: 94.9% to 97.8%) and 72.4% (95% CI: 67.2% to 77.1%), respectively. NPV was not influenced by patient characteristics or clinical risk profile and was similar in the very early and the standard strategy group.CONCLUSIONS: Coronary CTA has a high diagnostic accuracy to rule out clinically significant coronary artery disease in patients with NSTEACS.

Published
2020

15. Left atrial volume and function in patients following ST elevation myocardial infarction and the association with clinical outcome: a cardiovascular magnetic resonance study

Author

Lønborg, Jacob Thomsen, Engstrøm, Thomas, Møller, Jacob Eifer, Ahtarovski, Kiril A., Kelbæk, Henning, Holmvang, Lene, Jørgensen, Erik, Helqvist, Steffen, Saunamäki, Kari, Søholm, Helle, Andersen, Mads, Mathiasen, Anders B., Kühl, Jørgen Tobias, Clemmensen, Peter, Køber, Lars, and Vejlstrup, Niels

Published
2013
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22. Tissue coverage of a hydrophilic polymer-coated zotarolimus-eluting stent vs. a fluoropolymer-coated everolimus-eluting stent at 13-month follow-up: an optical coherence tomography substudy from the RESOLUTE All Comers trial

Author

Gutiérrez-Chico, Juan Luis, van Geuns, Robert Jan, Regar, Evelyn, van der Giessen, Willem J., Kelbæk, Henning, Saunamäki, Kari, Escaned, Javier, Gonzalo, Nieves, di Mario, Carlo, Borgia, Francesco, Nüesch, Eveline, García-García, Héctor M., Silber, Sigmund, Windecker, Stephan, and Serruys, Patrick W.

Published
2011
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23. Soluble urokinase receptor as a predictor of non-cardiac mortality in patients with percutaneous coronary intervention treated ST-segment elevation myocardial infarction

Author

Sandø, Andreas, primary, Schultz, Martin, additional, Eugen-Olsen, Jesper, additional, Køber, Lars, additional, Engstrøm, Thomas, additional, Kelbæk, Henning, additional, Jørgensen, Erik, additional, Saunamäki, Kari, additional, Holmvang, Lene, additional, Pedersen, Frants, additional, Tilsted, Hans Henrik, additional, Høfsten, Dan, additional, Helqvist, Steffen, additional, Clemmensen, Peter, additional, and Iversen, Kasper, additional

Published
2020
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24. Correction: Acute kidney injury – A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction

Author

El-Ahmadi, Abdellatif, primary, Abassi, Mujahed Sebastian, additional, Andersson, Hedvig Bille, additional, Engstrøm, Thomas, additional, Clemmensen, Peter, additional, Helqvist, Steffen, additional, Jørgensen, Erik, additional, Kelbæk, Henning, additional, Pedersen, Frants, additional, Saunamäki, Kari, additional, Lønborg, Jacob, additional, and Holmvang, Lene, additional

Published
2020
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25. Coronary CT Angiography in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome

Author

Linde, Jesper J., primary, Kelbæk, Henning, additional, Hansen, Thomas F., additional, Sigvardsen, Per E., additional, Torp-Pedersen, Christian, additional, Bech, Jan, additional, Heitmann, Merete, additional, Nielsen, Olav W., additional, Høfsten, Dan, additional, Kühl, Jørgen T., additional, Raymond, Ilan E., additional, Kristiansen, Ole P., additional, Svendsen, Ida H., additional, Vall-Lamora, Maria H.D., additional, Kragelund, Charlotte, additional, de Knegt, Martina, additional, Hove, Jens D., additional, Jørgensen, Tem, additional, Fornitz, Gitte G., additional, Steffensen, Rolf, additional, Jurlander, Birgit, additional, Abdulla, Jawdat, additional, Lyngbæk, Stig, additional, Elming, Hanne, additional, Therkelsen, Susette K., additional, Jørgensen, Erik, additional, Kløvgaard, Lene, additional, Bang, Lia Evi, additional, Hansen, Peter Riis, additional, Helqvist, Steffen, additional, Galatius, Søren, additional, Pedersen, Frants, additional, Abildgaard, Ulrik, additional, Clemmensen, Peter, additional, Saunamäki, Kari, additional, Holmvang, Lene, additional, Engstrøm, Thomas, additional, Gislason, Gunnar, additional, Køber, Lars V., additional, and Kofoed, Klaus F., additional

Published
2020
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27. Acute kidney injury – A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction

Author

El-Ahmadi, Abdellatif, primary, Abassi, Mujahed Sebastian, additional, Andersson, Hedvig Bille, additional, Engstrøm, Thomas, additional, Clemmensen, Peter, additional, Helqvist, Steffen, additional, Jørgensen, Erik, additional, Kelbæk, Henning, additional, Pedersen, Frants, additional, Saunamäki, Kari, additional, Lønborg, Jacob, additional, and Holmvang, Lene, additional

Published
2019
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30. Comparison of Paclitaxel- and Sirolimus-Eluting Stents in Everyday Clinical Practice: The SORT OUT II Randomized Trial

Author

Galløe, Anders M., Thuesen, Leif, Kelbæk, Henning, Thayssen, Per, Rasmussen, Klaus, Hansen, Peter R., Bligaard, Niels, Saunamäki, Kari, Junker, Anders, Aarøe, Jens, Abildgaard, Ulrik, Ravkilde, Jan, Engstrøm, Thomas, Jensen, Jan S., Andersen, Henning R., Bøtker, Hans E., Galatius, Søren, Kristensen, Steen D., Madsen, Jan K., Krusell, Lars R., Abildstrøm, Steen Z., Stephansen, Ghita B., and Lassen, Jens F.

Published
2008

31. Complete Revascularization Versus Culprit Lesion Only in Patients With ST-Segment Elevation Myocardial Infarction and Multivessel Disease:A DANAMI-3–PRIMULTI Cardiac Magnetic Resonance Substudy

Author

Kyhl, Kasper, Ahtarovski, Kiril Aleksov, Nepper-Christensen, Lars, Ekström, Kathrine, Ghotbi, Adam Ali, Schoos, Mikkel, Göransson, Christoffer, Bertelsen, Litten, Helqvist, Steffen, Holmvang, Lene, Jørgensen, Erik, Pedersen, Frants, Saunamäki, Kari, Clemmensen, Peter, De Backer, Ole, Høfsten, Dan Eik, Køber, Lars, Kelbæk, Henning, Vejlstrup, Niels, Lønborg, Jacob, and Engstrøm, Thomas

Subjects
ST-segment elevation myocardial infarction, cardiovascular magnetic resonance, complete revascularization, acute myocardial infarction, cardiovascular diseases, cardiac function, cardiac remodeling, randomization, primary percutaneous coronary intervention, randomized study, culprit lesion
Abstract

Objectives: The aim of this study was to evaluate the effect of fractional flow reserve (FFR)–guided revascularization compared with culprit-only percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) on infarct size, left ventricular (LV), function, LV remodeling, and the presence of nonculprit infarctions. Background: Patients with STEMI with multivessel disease might have improved clinical outcomes after complete revascularization compared with PCI of the infarct-related artery only, but the impact on infarct size, LV function, and remodeling as well as the risk for periprocedural infarction are unknown. Methods: In this substudy of the DANAMI-3 (Third Danish Trial in Acute Myocardial Infarction)–PRIMULTI (Primary PCI in Patients With ST-Elevation Myocardial Infarction and Multivessel Disease: Treatment of Culprit Lesion Only or Complete Revascularization) randomized trial, patients with STEMI with multivessel disease were randomized to receive either complete FFR-guided revascularization or PCI of the culprit vessel only. The patients underwent cardiac magnetic resonance imaging during index admission and at 3-month follow-up. Results: A total of 280 patients (136 patients with infarct-related and 144 with complete FFR-guided revascularization) were included. There were no differences in final infarct size (median 12% [interquartile range: 5% to 19%] vs. 11% [interquartile range: 4% to 18%]; p = 0.62), myocardial salvage index (median 0.71 [interquartile range: 0.54 to 0.89] vs. 0.66 [interquartile range: 0.55 to 0.87]; p = 0.49), LV ejection fraction (mean 58 ± 9% vs. 59 ± 9%; p = 0.39), and LV end-systolic volume remodeling (mean 7 ± 22 ml vs. 7 ± 19 ml; p = 0.63). New nonculprit infarction occurring after the nonculprit intervention was numerically more frequent among patients treated with complete revascularization (6 [4.5%] vs. 1 [0.8%]; p = 0.12). Conclusions: Complete FFR-guided revascularization in patients with STEMI and multivessel disease did not affect final infarct size, LV function, or remodeling compared with culprit-only PCI.

Published
2019

32. Revascularization Compared to Medical Treatment in Patients with Silent vs. Symptomatic Residual Ischemia after Thrombolyzed Myocardial Infarction - The DANAMI Study

Author

Madsen, Jan K., Nielsen, Torsten T., Grande, Peer, Eriksen, Ulrik H., Saunamäki, Kari, Thayssen, Per, Kassis, Eli, Rasmussen, Klaus, Haunsø, Stig, Haghfelt, Torben, Fritz-Hansen, Per, Hjelms, Erik, Paulsen, Peter K., Alstrup, Poul, Arendrup, Henrik, Niebuhr-Jørgensen, Uffe, and Andersen, Lars I.

Published
2007
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38. Acute kidney injury:A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction

Author

El-Ahmadi, Abdellatif, Abassi, Mujahed Sebastian, Andersson, Hedvig Bille, Engstrøm, Thomas, Clemmensen, Peter, Helqvist, Steffen, Jørgensen, Erik, Kelbæk, Henning, Pedersen, Frants, Saunamäki, Kari, Lønborg, Jacob, Holmvang, Lene, El-Ahmadi, Abdellatif, Abassi, Mujahed Sebastian, Andersson, Hedvig Bille, Engstrøm, Thomas, Clemmensen, Peter, Helqvist, Steffen, Jørgensen, Erik, Kelbæk, Henning, Pedersen, Frants, Saunamäki, Kari, Lønborg, Jacob, and Holmvang, Lene

Abstract

Objectives The aim of the study was to investigate the incidence, risk factors and long-term prognosis of acute kidney injury (AKI) in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (primary PCI). Method A large-scale, retrospective cohort study based on procedure-related variables, biochemical and mortality data collected between 2009 and 2014 at Rigshospitalet, Copenhagen, Denmark. AKI was defined as an increase in serum creatinine of 25% during the first 72 hours after the index procedure. Results A total of 4239 patients were treated with primary PCI of whom 4002 had available creatinine measurements allowing for assessment of AKI and inclusion in this study. The mean creatinine value upon presentation for all patients was 84 μmol/l (standard deviation (SD) ±40) and 97 μmol/l (SD ±53) at peak. AKI occurred in a total of 765 (19.1%) patients. Independent risk factors for the occurrence of AKI were age, time from symptom onset to procedure, peak value of troponin-T, female sex and the contrast volume to eGFR ratio. In a multivariable adjusted analysis AKI was independently associated with a higher mortality rate at 5 years follow-up (hazard ratio 1.39 [95%-confidence interval 1.03–1.88]). Conclusion In STEMI patients treated with primary PCI one in five experiences acute kidney injury, which was associated with a substantial increase in both short- and long-term mortality.

Published
2019

39. Complete Revascularization Versus Culprit Lesion Only in Patients With ST-Segment Elevation Myocardial Infarction and Multivessel Disease

Author

Kyhl, Kasper, Ahtarovski, Kiril Aleksov, Nepper-Christensen, Lars, Ekström, Kathrine, Ghotbi, Adam Ali, Schoos, Mikkel, Göransson, Christoffer, Bertelsen, Litten, Helqvist, Steffen, Holmvang, Lene, Jørgensen, Erik, Pedersen, Frants, Saunamäki, Kari, Clemmensen, Peter, De Backer, Ole, Høfsten, Dan Eik, Køber, Lars, Kelbæk, Henning, Vejlstrup, Niels, Lønborg, Jacob, Engstrøm, Thomas, Kyhl, Kasper, Ahtarovski, Kiril Aleksov, Nepper-Christensen, Lars, Ekström, Kathrine, Ghotbi, Adam Ali, Schoos, Mikkel, Göransson, Christoffer, Bertelsen, Litten, Helqvist, Steffen, Holmvang, Lene, Jørgensen, Erik, Pedersen, Frants, Saunamäki, Kari, Clemmensen, Peter, De Backer, Ole, Høfsten, Dan Eik, Køber, Lars, Kelbæk, Henning, Vejlstrup, Niels, Lønborg, Jacob, and Engstrøm, Thomas

Published
2019

40. Can acute stress be fatal? A systematic cross-disciplinary review

Author

Baltzer Nielsen, Solveig, Stanislaus, Sharleny, Saunamäki, Kari, Grøndahl, Carsten, Banner, Jytte, Jørgensen, Martin Balslev, Baltzer Nielsen, Solveig, Stanislaus, Sharleny, Saunamäki, Kari, Grøndahl, Carsten, Banner, Jytte, and Jørgensen, Martin Balslev

Abstract

In this review it is discussed if acute stress can be fatal. The review is based on literature searches on PubMed, PsycINFO as well as Web of Science. Literature concerning the conditions excited delirium syndrome (ExDS), malignant catatonia, takotsubo cardiomyopathy (TCM), and capture myopathy (CM) is reviewed and compared. The aim of the article is to identify and discuss a possible fatalness as well as a common pathophysiology behind these conditions. This includes a deregulated autonomic nervous system, neurocardiac reasons for myocardial damage, and rhabdomyolysis. We conclude that these conditions could be different manifestations of the same pathophysiological phenomenon. In addition, we suggest that it is possible to die from acute stress, but that it requires a prior sensitization, as seen in cocaine abusers and certain psychiatric patients, to render individuals disposed to an extreme autonomic nerve reaction. Lay summary This article compares different conditions in humans and in other animals, where it appears as if the human or animal dies with no other reason than being submitted to an extreme condition of mental stress. The conditions examined via a literature search are excited delirium syndrome, malignant catatonia and takotsubo cardiomyopathy in humans, and a capture myopathy in different mammals. The article theoretically suggests that one can die solely from acute stress, but that different forms sensitization probably goes ahead of such a fatal stress reaction. E.g. in cocaine addicts, some psychiatric patients, and in wild animals formerly subjected to stress an extreme sympathetic stress response might be immediately fatal. The article also theorizes that excited delirium syndrome, malignant catatonia, and capture myopathy could be more severe and acute variants of the temporary condition seen in takotsubo patients, also known as patients with broken heart syndrome.

Published
2019

44. Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial

Author

Hausenloy, Derek J, primary, Kharbanda, Rajesh K, additional, Møller, Ulla Kristine, additional, Ramlall, Manish, additional, Aarøe, Jens, additional, Butler, Robert, additional, Bulluck, Heerajnarain, additional, Clayton, Tim, additional, Dana, Ali, additional, Dodd, Matthew, additional, Engstrom, Thomas, additional, Evans, Richard, additional, Lassen, Jens Flensted, additional, Christensen, Erika Frischknecht, additional, Garcia-Ruiz, José Manuel, additional, Gorog, Diana A, additional, Hjort, Jakob, additional, Houghton, Richard F, additional, Ibanez, Borja, additional, Knight, Rosemary, additional, Lippert, Freddy K, additional, Lønborg, Jacob T, additional, Maeng, Michael, additional, Milasinovic, Dejan, additional, More, Ranjit, additional, Nicholas, Jennifer M, additional, Jensen, Lisette Okkels, additional, Perkins, Alexander, additional, Radovanovic, Nebojsa, additional, Rakhit, Roby D, additional, Ravkilde, Jan, additional, Ryding, Alisdair D, additional, Schmidt, Michael R, additional, Riddervold, Ingunn Skogstad, additional, Sørensen, Henrik Toft, additional, Stankovic, Goran, additional, Varma, Madhusudhan, additional, Webb, Ian, additional, Terkelsen, Christian Juhl, additional, Greenwood, John P, additional, Yellon, Derek M, additional, Bøtker, Hans Erik, additional, Junker, Anders, additional, Kaltoft, Anne, additional, Madsen, Morten, additional, Christiansen, Evald Høj, additional, Jakobsen, Lars, additional, Carstensen, Steen, additional, Kristensen, Steen Dalby, additional, Thim, Troels, additional, Pedersen, Karin Møller, additional, Korsgaard, Mette Tidemand, additional, Iversen, Allan, additional, Jørgensen, Erik, additional, Joshi, Francis, additional, Pedersen, Frants, additional, Tilsted, Hans Henrik, additional, Alzuhairi, Karam, additional, Saunamäki, Kari, additional, Holmvang, Lene, additional, Ahlehof, Ole, additional, Sørensen, Rikke, additional, Helqvist, Steffen, additional, Mark, Bettina Løjmand, additional, Villadsen, Anton Boel, additional, Raungaard, Bent, additional, Thuesen, Leif, additional, Christiansen, Martin Kirk, additional, Freeman, Philip, additional, Jensen, Svend Eggert, additional, Skov, Charlotte Schmidt, additional, Aziz, Ahmed, additional, Hansen, Henrik Steen, additional, Ellert, Julia, additional, Veien, Karsten, additional, Pedersen, Knud Erik, additional, Hansen, Knud Nørregård, additional, Ahlehoff, Ole, additional, Cappelen, Helle, additional, Wittrock, Daniel, additional, Hansen, Poul Anders, additional, Ankersen, Jens Peter, additional, Hedegaard, Kim Witting, additional, Kempel, John, additional, Kaus, Henning, additional, Erntgaard, Dennis, additional, Pedersen, Danny Mejsner, additional, Giebner, Matthias, additional, Hansen, Troels Martin Hansen, additional, Radosavljevic-Radovanovic, Mina, additional, Prodanovic, Maja, additional, Savic, Lidija, additional, Pejic, Marijana, additional, Matic, Dragan, additional, Uscumlic, Ana, additional, Subotic, Ida, additional, Lasica, Ratko, additional, Vukcevic, Vladan, additional, Suárez, Alfonso, additional, Samaniego, Beatriz, additional, Morís, César, additional, Segovia, Eduardo, additional, Hernández, Ernesto, additional, Lozano, Iñigo, additional, Pascual, Isaac, additional, Vegas-Valle, Jose M., additional, Rozado, José, additional, Rondán, Juan, additional, Avanzas, Pablo, additional, del Valle, Raquel, additional, Padrón, Remigio, additional, García-Castro, Alfonso, additional, Arango, Amalia, additional, Medina-Cameán, Ana B., additional, Fente, Ana I., additional, Muriel-Velasco, Ana, additional, Pomar-Amillo, Ángeles, additional, Roza, César L., additional, Martínez-Fernández, César M., additional, Buelga-Díaz, Covadonga, additional, Fernández-Gonzalo, David, additional, Fernández, Elena, additional, Díaz-González, Eloy, additional, Martinez-González, Eugenio, additional, Iglesias-Llaca, Fernando, additional, Viribay, Fernando M., additional, Fernández-Mallo, Francisco J., additional, Hermosa, Francisco J., additional, Martínez-Bastida, Ginés, additional, Goitia-Martín, Javier, additional, Vega-Fernández, José L., additional, Tresguerres, Jose M., additional, Rodil-Díaz, Juan A., additional, Villar-Fernández, Lara, additional, Alberdi, Lucía, additional, Abella-Ovalle, Luis, additional, de la Roz, Manuel, additional, Fernández-Carral, Marcos Fernández-Carral, additional, Naves, María C., additional, Peláez, María C., additional, Fuentes, María D., additional, García-Alonso, María, additional, Villanueva, María J., additional, Vinagrero, María S., additional, Vázquez-Suárez, María, additional, Martínez-Valle, Marta, additional, Nonide, Marta, additional, Pozo-López, Mónica, additional, Bernardo-Alba, Pablo, additional, Galván-Núñez, Pablo, additional, Martínez-Pérez, Polácido J., additional, Castro, Rafael, additional, Suárez-Coto, Raquel, additional, Suárez-Noriega, Raquel, additional, Guinea, Rocío, additional, Quintana, Rosa B., additional, de Cima, Sara, additional, Hedrera, Segundo A., additional, Laca, Sonia I., additional, Llorente-Álvarez, Susana, additional, Pascual, Susana, additional, Cimas, Teodorna, additional, Mathur, Anthony, additional, McFarlane-Henry, Eleanor, additional, Leonard, Gerry, additional, Veerapen, Jessry, additional, Westwood, Mark, additional, Colicchia, Martina, additional, Prossora, Mary, additional, Andiapen, Mervyn, additional, Mohiddin, Saidi, additional, Lenzi, Valentina, additional, Chong, Jun, additional, Francis, Rohin, additional, Pine, Amy, additional, Jamieson-Leadbitter, Caroline, additional, Neal, Debbie, additional, Din, J., additional, McLeod, Jane, additional, Roberts, Josh, additional, Polokova, Karin, additional, Longman, Kristel, additional, Penney, Lucy, additional, Lakeman, Nicki, additional, Wells, Nicki, additional, Hopper, Oliver, additional, Coward, Paul, additional, O'Kane, Peter, additional, Harkins, Ruth, additional, Guyatt, Samantha, additional, Kennard, Sarah, additional, Orr, Sarah, additional, Horler, Stephanie, additional, Morris, Steve, additional, Walvin, Tom, additional, Snow, Tom, additional, Cunnington, Michael, additional, Burd, Amanda, additional, Gowing, Anne, additional, Krishnamurthy, Arvindra, additional, Harland, Charlotte, additional, Norfolk, Derek, additional, Johnstone, Donna, additional, Newman, Hannah, additional, Reed, Helen, additional, O'Neill, James, additional, Greenwood, John, additional, Cuxton, Josephine, additional, Corrigan, Julie, additional, Somers, Kathryn, additional, Anderson, Michelle, additional, Burtonwood, Natalie, additional, Bijsterveld, Petra, additional, Brogan, Richard, additional, Ryan, Tony, additional, Kodoth, Vivek, additional, Khan, Arif, additional, Sebastian, Deepti, additional, Gorog, Diana, additional, Boyle, Georgina, additional, Shepherd, Lucy, additional, Hamid, Mahmood, additional, Farag, Mohamed, additional, Spinthakis, Nicholas, additional, Waitrak, Paulina, additional, De Sousa, Phillipa, additional, Bhatti, Rishma, additional, Oliver, Victoria, additional, Walshe, Siobhan, additional, Odedra, Toral, additional, Gue, Ying, additional, Kanji, Rahim, additional, Ryding, Alisdair, additional, Ratcliffe, Amanda, additional, Merrick, Angela, additional, Horwood, Carol, additional, Sarti, Charlotte, additional, Maart, Clint, additional, Moore, Donna, additional, Dockerty, Francesca, additional, Baucutt, Karen, additional, Pitcher, Louise, additional, Ilsley, Mary, additional, Clarke, Millie, additional, Germon, Rachel, additional, Gomes, Sara, additional, Clare, Thomas, additional, Nair, Sunil, additional, Staines, Jocasta, additional, Nicholson, Susan, additional, Watkinson, Oliver, additional, Gallagher, Ian, additional, Nelthorpe, Faye, additional, Musselwhite, Janine, additional, Grosser, Konrad, additional, Stimson, Leah, additional, Eaton, Michelle, additional, Heppell, Richard, additional, Turney, Sharon, additional, Horner, Victoria, additional, Schumacher, Natasha, additional, Moon, Angela, additional, Mota, Paula, additional, O'Donnell, Joshua, additional, Panicker, Abeesh Sadasiva, additional, Musa, Anntoniette, additional, Tapp, Luke, additional, Krishnamoorthy, Suresh, additional, Ansell, Valerie, additional, Ali, Danish, additional, Hyndman, Samantha, additional, Banerjee, Prithwish, additional, Been, Martin, additional, Mackenzie, Ailie, additional, McGregor, Andrew, additional, Hildick-Smith, David, additional, Champney, Felicity, additional, Ingoldby, Fiona, additional, Keate, Kirstie, additional, Bennett, Lorraine, additional, Skipper, Nicola, additional, Gregory, Sally, additional, Harfield, Scott, additional, Mudd, Alexandra, additional, Wragg, Christopher, additional, Barmby, David, additional, Grech, Ever, additional, Hall, Ian, additional, Middle, Janet, additional, Barker, Joann, additional, Fofie, Joyce, additional, Gunn, Julian, additional, Housley, Kay, additional, Cockayne, Laura, additional, Weatherlley, Louise, additional, Theodorou, Nana, additional, Wheeldon, Nigel, additional, Fati, Pene, additional, Storey, Robert F., additional, Richardson, James, additional, Iqbal,, Javid, additional, Adam, Zul, additional, Brett, Sarah, additional, Agyemang, Michael, additional, Tawiah, Cecilia, additional, Hogrefe, Kai, additional, Raju, Prashanth, additional, Braybrook, Christine, additional, Gracey, Jay, additional, Waldron, Molly, additional, Holloway, Rachael, additional, Burunsuzoglu, Senem, additional, Sidgwick, Sian, additional, Hetherington, Simon, additional, Beirnes, Charmaine, additional, Fernandez, Olga, additional, Lazar, Nicoleta, additional, Knighton, Abigail, additional, Rai, Amrit, additional, Hoare, Amy, additional, Breeze, Jonathan, additional, Martin, Katherine, additional, Andrews, Michelle, additional, Patale, Sheetal, additional, Bennett, Amy, additional, Smallwood, Andrew, additional, Radford, Elizabeth, additional, Cotton, James, additional, Martins, Joe, additional, Wallace, Lauren, additional, Milgate, Sarah, additional, Munir, Shahzad, additional, Metherell, Stella, additional, Cottam, Victoria, additional, Massey, Ian, additional, Copestick, Jane, additional, Delaney, Jane, additional, Wain, Jill, additional, Sandhu, Kully, additional, Emery, Lisa, additional, Hall, Charlotte, additional, Bucciarelli-Ducci, Chiara, additional, Besana, Rissa, additional, Hussein, Jodie, additional, Bell, Sheila, additional, Gill, Abby, additional, Bales, Emily, additional, Polwarth, Gary, additional, East, Clare, additional, Smith, Ian, additional, Oliveira, Joana, additional, Victor, Saji, additional, Woods, Sarah, additional, Hoole, Stephen, additional, Ramos, Angelo, additional, Sevillano, Annaliza, additional, Nicholson, Anne, additional, Solieri, Ashley, additional, Redman, Emily, additional, Byrne, Jean, additional, Joyce, Joan, additional, Riches, Joanne, additional, Davies, John, additional, Allen, Kezia, additional, Saclot, Louie, additional, Ocampo, Madelaine, additional, Vertue, Mark, additional, Christmas, Natasha, additional, Koothoor, Raiji, additional, Gamma, Reto, additional, Alvares, Wilson, additional, Pepper, Stacey, additional, Kobson, Barbara, additional, Reeve, Christy, additional, Malik, Iqbal, additional, Chester, Emma, additional, Saunders, Heidi, additional, Mojela, Idah, additional, Smee, Joanna, additional, Davies, Justin, additional, Davies, Nina, additional, Clifford, Piers, additional, Dias, Priyanthi, additional, Kaur, Ramandeep, additional, Moreira, Silvia, additional, Ahmad, Yousif, additional, Tomlinson, Lucy, additional, Pengelley, Clare, additional, Bidle, Amanda, additional, Spence, Sharon, additional, Al-Lamee, Rasha, additional, Phuyal, Urmila, additional, Abbass, Hakam, additional, Bose, Tuhina, additional, Elliott, Rebecca, additional, Foundun, Aboo, additional, Chung, Alan, additional, Freestone, Beth, additional, Lee, Dr Kaeng, additional, Elshiekh, Dr Mohamed, additional, Pulikal, George, additional, Bhatre, Gurbir, additional, Douglas, James, additional, Kaeng, Lee, additional, Pitt, Mike, additional, Watkins, Richard, additional, Gill, Simrat, additional, Hartley, Amy, additional, Lucking, Andrew, additional, Moreby, Berni, additional, Darby, Damaris, additional, Corps, Ellie, additional, Parsons, Georgina, additional, De Mance, Gianluigi, additional, Fahrai, Gregor, additional, Turner, Jenny, additional, Langrish, Jeremy, additional, Gaughran, Lisa, additional, Wolyrum, Mathias, additional, Azkhalil, Mohammed, additional, Bates, Rachel, additional, Given, Rachel, additional, Kharbanda, Rajesh, additional, Douthwaite, Rebecca, additional, Lloyd, Steph, additional, Neubauer, Stephen, additional, Barker, Deborah, additional, Suttling, Anne, additional, Turner, Charlotte, additional, Smith, Clare, additional, Longbottom, Colin, additional, Ross, David, additional, Cunliffe, Denise, additional, Cox, Emily, additional, Whitehead, Helena, additional, Hudson, Karen, additional, Jones, Leslie, additional, Drew, Martin, additional, Chant, Nicholas, additional, Haworth, Peter, additional, Capel, Robert, additional, Austin, Rosalynn, additional, Howe, Serena, additional, Smith, Trevor, additional, Hobson, Alex, additional, Strike, Philip, additional, Griffiths, Huw, additional, Anantharam, Brijesh, additional, Jack, Pearse, additional, Thornton, Emma, additional, Hodgson, Adrian, additional, Jennison, Alan, additional, McSkeane, Anna, additional, Smith, Bethany, additional, Shaw, Caroline, additional, Leathers, Chris, additional, Armstrong, Elissa, additional, Carruthers, Gayle, additional, Simpson, Holly, additional, Smith, Jan, additional, Hodierne, Jeremy, additional, Kelly, Julie, additional, Barclay, Justin, additional, Scott, Kerry, additional, Gregson, Lisa, additional, Buchanan, Louise, additional, McCormick, Louise, additional, Kelsall, Nicci, additional, Mcarthy, Rachel, additional, Taylor, Rebecca, additional, Thompson, Rebecca, additional, Shelton, Rhidian, additional, Moore, Roger, additional, Tomlinson, Sharon, additional, Thambi, Sunil, additional, Cooper, Theresa, additional, Oakes, Trevor, additional, Deen, Zakhira, additional, Relph, Chris, additional, prentice, Scott, additional, Hall, Lorna, additional, Dillon, Angela, additional, Meadows, Deborah, additional, Frank, Emma, additional, Markham-Jones, Helene, additional, Thomas, Isobel, additional, Gale, Joanne, additional, Denman, Joanne, additional, O'Connor, John, additional, Hindle, Julia, additional, Jackson-Lawrence, Karen, additional, Warner, Karen, additional, Lee, Kelvin, additional, Upton, Robert, additional, Elston, Ruth, additional, Lee, Sandra, additional, Venugopal, Vinod, additional, Finch, Amanda, additional, Fleming, Catherine, additional, Whiteside, Charlene, additional, Pemberton, Chris, additional, Wilkinson, Conor, additional, Sebastian, Deepa, additional, Riedel, Ella, additional, Giuffrida, Gaia, additional, Burnett, Gillian, additional, Spickett, Helen, additional, Glen, James, additional, Brown, Janette, additional, Thornborough, Lauren, additional, Pedley, Lauren, additional, Morgan, Maureen, additional, Waddington, Natalia, additional, Brennan, Oliver, additional, Brady, Rebecca, additional, Preston, Stephen, additional, Loder, Chris, additional, Vlad, Ionela, additional, Laurence, Julia, additional, Smit, Angelique, additional, Dimond, Kirsty, additional, Hayes, Michelle, additional, Paddy, Loveth, additional, Crause, Jacolene, additional, Amed, Nadifa, additional, Kaur-Babooa, Priya, additional, Rakhit, Roby, additional, Kotecha, Tushar, additional, Fayed, Hossam, additional, Pavlidis, Antonis, additional, Prendergast, Bernard, additional, Clapp, Brian, additional, Perara, Divaka, additional, Atkinson, Emma, additional, Ellis, Howard, additional, Wilson, Karen, additional, Gibson, Kirsty, additional, Smith, Megan, additional, Khawaja, Muhammed Zeeshan, additional, Sanchez-Vidal, Ruth, additional, Redwood, Simon, additional, Jones, Sophie, additional, Tipping, Aoife, additional, Oommen, Anu, additional, Hendry, Cara, additional, Fath-Orboubadi, DR Fazin, additional, Phillips, Hannah, additional, Kolakaluri, Laurel, additional, Sherwood, Martin, additional, Mackie, Sarah, additional, Aleti, Shilpa, additional, Charles, Thabitha, additional, Roy, Liby, additional, Henderson, Rob, additional, Stables, Rod, additional, Marber, Michael, additional, Berry, Alan, additional, Redington, Andrew, additional, Thygesen, Kristian, additional, Andersen, Henning Rud, additional, Berry, Colin, additional, Copas, Andrew, additional, Meade, Tom, additional, Kelbæk, Henning, additional, Bueno, Hector, additional, von Weitzel-Mudersbach, Paul, additional, Andersen, Grethe, additional, Ludman, Andrew, additional, Cruden, Nick, additional, Topic, Dragan, additional, Mehmedbegovic, Zlatko, additional, de la Hera Galarza, Jesus Maria, additional, Robertson, Steven, additional, Van Dyck, Laura, additional, Chu, Rebecca, additional, Astarci, Josenir, additional, Jamal, Zahra, additional, Hetherington, Daniel, additional, and Collier, Lucy, additional

Published
2019
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45. Complete Revascularization Versus Culprit Lesion Only in Patients With ST-Segment Elevation Myocardial Infarction and Multivessel Disease

Author

Kyhl, Kasper, primary, Ahtarovski, Kiril Aleksov, additional, Nepper-Christensen, Lars, additional, Ekström, Kathrine, additional, Ghotbi, Adam Ali, additional, Schoos, Mikkel, additional, Göransson, Christoffer, additional, Bertelsen, Litten, additional, Helqvist, Steffen, additional, Holmvang, Lene, additional, Jørgensen, Erik, additional, Pedersen, Frants, additional, Saunamäki, Kari, additional, Clemmensen, Peter, additional, De Backer, Ole, additional, Høfsten, Dan Eik, additional, Køber, Lars, additional, Kelbæk, Henning, additional, Vejlstrup, Niels, additional, Lønborg, Jacob, additional, and Engstrøm, Thomas, additional

Published
2019
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47. Long-term survival and causes of death in patients with ST-elevation acute coronary syndrome without obstructive coronary artery disease

Author

Andersson, Hedvig Bille, Pedersen, Frants, Engstrøm, Thomas, Helqvist, Steffen, Jensen, Morten Kvistholm, Jørgensen, Erik, Kelbæk, Henning, Räder, Sune Bernd Emil Werner, Saunamäki, Kari, Bates, Eric, Grande, Peer, Holmvang, Lene, Clemmensen, Peter, Andersson, Hedvig Bille, Pedersen, Frants, Engstrøm, Thomas, Helqvist, Steffen, Jensen, Morten Kvistholm, Jørgensen, Erik, Kelbæk, Henning, Räder, Sune Bernd Emil Werner, Saunamäki, Kari, Bates, Eric, Grande, Peer, Holmvang, Lene, and Clemmensen, Peter

Abstract

Aims: We aimed to study survival and causes of death in patients with ST-elevation acute coronary syndrome (STE-ACS) with and without obstructive coronary artery disease (CAD).Methods and results: We included 4793 consecutive patients with STE-ACS triaged for acute coronary angiography at a large cardiac invasive centre (2009-2014). Of these, 88% had obstructive CAD (stenosis ≥50%), 6% had non-obstructive CAD (stenosis 1-49%), and 5% had normal coronary arteries. Patients without obstructive CAD were younger and more often female with fewer cardiovascular risk factors. Median follow-up time was 2.6 years. Compared with patients with obstructive CAD, the short-term hazard of death (≤30 days) was lower in both patients with non-obstructive CAD [hazard ratio (HR) 0.49, 95% confidence interval (CI) 0.27-0.89, P = 0.018] and normal coronary arteries (HR 0.31, 95% CI 0.11-0.83, P = 0.021). In contrast, the long-term hazard of death (>30 days) was similar in patients with non-obstructive CAD (HR 1.15, 95% CI 0.77-1.72, P = 0.487) and higher in patients with normal coronary arteries (HR 2.44, 95% CI 1.58-3.76, P < 0.001), regardless of troponin levels. Causes of death were cardiovascular in 70% of patients with obstructive CAD, 38% with non-obstructive CAD, and 32% with normal coronary arteries. Finally, patients without obstructive CAD had lower survival compared with an age and sex matched general population.Conclusions: STE-ACS patients without obstructive CAD had a long-term risk of death similar to or higher than patients with obstructive CAD. Causes of death were less often cardiovascular. This suggests that STE-ACS patients without obstructive CAD warrant medical attention and close follow-up.

Published
2018

48. Bleeding Events After ST-segment Elevation Myocardial Infarction in Patients Randomized to an All-comer Clinical Trial Compared With Unselected Patients

Author

Sadjadieh, Golnaz, Engstrøm, Thomas, Høfsten, Dan Eik, Helqvist, Steffen, Køber, Lars, Pedersen, Frants, Laursen, Peter Nørkjær, Andersson, Hedvig Bille, Nepper-Christensen, Lars, Clemmensen, Peter, Sørensen, Rikke, Jørgensen, Erik, Saunamäki, Kari, Tilsted, Hans-Henrik, Kelbæk, Henning, Holmvang, Lene, Sadjadieh, Golnaz, Engstrøm, Thomas, Høfsten, Dan Eik, Helqvist, Steffen, Køber, Lars, Pedersen, Frants, Laursen, Peter Nørkjær, Andersson, Hedvig Bille, Nepper-Christensen, Lars, Clemmensen, Peter, Sørensen, Rikke, Jørgensen, Erik, Saunamäki, Kari, Tilsted, Hans-Henrik, Kelbæk, Henning, and Holmvang, Lene

Abstract

Most studies reporting bleedings in patients with ST-segment elevation myocardial infarction (STEMI) are reports from clinical trials, which may be unrepresentative of incidences in real-life. In this study, we investigated 1-year bleeding and mortality incidences in an unselected STEMI population, and compared participants with nonparticipants of a randomized all-comer clinical trial (The Third DANish Study of Optimal Acute Treatment of Patients with STEMI (DANAMI-3)). Hospital charts were read and bleedings classified according to thrombolysis in myocardial infarction (TIMI) and Bleeding Academic Research Consortium (BARC) criteria in 2,490 consecutive STEMI patients who underwent primary percutaneous coronary intervention in a single, large, and tertiary heart center. Thrombolysis in myocardial infarction minor and/or major bleeding (TMMB) occurred in 4.4% day 0 to 30 and 2.1% day 31 to 365. DANAMI-3 nonparticipants (n = 887) had significantly higher 30-day bleeding rates than DANAMI-3-participants (n = 1,603) (7.2% vs 2.9%, p <0.0001), but not thereafter (p = 0.8). DANAMI-3 nonparticipation was significantly associated with 30-day TMMB (hazard ratio, 1.8, 95% confidence interval, 1.2 to 2.8, p = 0.007), but this did not persist after adjusting for resuscitated cardiac arrest, Killip-class>2 and anemia. Patients with cardiac arrest, Killip-class>2, and anemia accounted for 70.0% of 30-day TMMBs, and the majority of these patients were DANAMI-3 nonparticipants. TMMB day 0 to 30 was associated with increased 30-day mortality (hazard ratio 3.1, 95% confidence interval 1.9 to 5.2, p <0.0001) but not thereafter (p = 0.9). In conclusion, we found that clinical trial (DANAMI-3) nonparticipants had significantly more TMMBs within 30 days than participants. Patients with resuscitated cardiac arrest, anemia, and Killip-class>2 were accountable for a high rate of TMMBs. Bleeding incidences from clinical trials cannot be translated to an unselected STEMI po

Published
2018

49. Relation of Bleeding Events to Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated by Percutaneous Coronary Intervention (a DANAMI-3 Substudy)

Author

Sadjadieh, Golnaz, Engstrøm, Thomas, Helqvist, Steffen, Høfsten, Dan Eik, Køber, Lars, Pedersen, Frants, Laursen, Peter Nørkjær, Nepper-Christensen, Lars, Clemmensen, Peter, Møller-Helgestad, Ole Kristian, Sørensen, Rikke, Ravkilde, Jan, Terkelsen, Christian Juhl, Jørgensen, Erik, Saunamäki, Kari, Tilsted, Hans-Henrik, Kelbæk, Henning, Holmvang, Lene, Sadjadieh, Golnaz, Engstrøm, Thomas, Helqvist, Steffen, Høfsten, Dan Eik, Køber, Lars, Pedersen, Frants, Laursen, Peter Nørkjær, Nepper-Christensen, Lars, Clemmensen, Peter, Møller-Helgestad, Ole Kristian, Sørensen, Rikke, Ravkilde, Jan, Terkelsen, Christian Juhl, Jørgensen, Erik, Saunamäki, Kari, Tilsted, Hans-Henrik, Kelbæk, Henning, and Holmvang, Lene

Abstract

Bleeding events in relation to treatment of ST-segment elevation myocardial infarction (STEMI) have previously been associated with mortality. In this study, we investigated the incidence and prognosis of, and variables associated with serious bleedings within 30 days after primary percutaneous coronary intervention in patients from The Third Danish Study of Optimal Acute Treatment of Patients with ST-Segment Elevation Myocardial Infarction (DANAMI-3) (n = 2,217). Hospital charts were read within 30 days postadmission to assess bleeding events using thrombolysis in myocardial infarction (TIMI) and Bleeding Academic Research Consortium criteria. TIMI minor/major bleeding (TMMB) occurred in 59 patients (2.7%). Variables associated with TMMB were female gender (hazard ratio [HR] 3.9, 95% confidence interval [CI] 2.2 to 6.7, p <0.0001), symptom-to-catheterization time >3 hours (HR 1.9, 95% CI 1.1 to 3.3, p = 0.02), use of glycoprotein IIb/IIIa inhibitor (HR 2.1, 95% CI 1.2 to 3.7, p = 0.01), and increasing S-creatinine (HR 1.1, 95% CI 1.0 to 1.2, p = 0.001). Undergoing 2 in-hospital procedures were not associated with increased risk of TMMB. TMMB was strongly associated with 30-day mortality in multivariable analysis (HR 4.8, 95% CI 2.2 to 10.4, p <0.0001) but not with mortality days 31 to 365. When excluding fatal bleedings from the analysis, a TMMB was no longer associated with 30-day mortality. In conclusion, we found that in a contemporary STEMI-population, the incidence of 30-day TMMB was low. A TMMB was strongly associated with 30-day mortality but not with mortality days 31 to 365. If patients survived a serious bleeding, their short- and long-term prognoses were not affected.

Published
2018

50. MR-proADM as a Prognostic Marker in Patients With ST-Segment-Elevation Myocardial Infarction - DANAMI-3 (a Danish Study of Optimal Acute Treatment of Patients With STEMI) Substudy

Author

Falkentoft, Alexander C, Rørth, Rasmus, Iversen, Kasper, Høfsten, Dan E, Kelbæk, Henning, Holmvang, Lene, Frydland, Martin, Schoos, Mikkel M, Helqvist, Steffen, Axelsson, Anna, Clemmensen, Peter, Jørgensen, Erik, Saunamäki, Kari, Tilsted, Hans-Henrik, Pedersen, Frants, Torp-Pedersen, Christian, Kofoed, Klaus F., Goetze, Jens P., Engstrøm, Thomas, Køber, Lars, Falkentoft, Alexander C, Rørth, Rasmus, Iversen, Kasper, Høfsten, Dan E, Kelbæk, Henning, Holmvang, Lene, Frydland, Martin, Schoos, Mikkel M, Helqvist, Steffen, Axelsson, Anna, Clemmensen, Peter, Jørgensen, Erik, Saunamäki, Kari, Tilsted, Hans-Henrik, Pedersen, Frants, Torp-Pedersen, Christian, Kofoed, Klaus F., Goetze, Jens P., Engstrøm, Thomas, and Køber, Lars

Abstract

BACKGROUND: Midregional proadrenomedullin (MR-proADM) has demonstrated prognostic potential after myocardial infarction (MI). Yet, the prognostic value of MR-proADM at admission has not been examined in patients with ST-segment-elevation MI (STEMI).METHODS AND RESULTS: The aim of this substudy, DANAMI-3 (The Danish Study of Optimal Acute Treatment of Patients with ST-segment-elevation myocardial infarction), was to examine the associations of admission concentrations of MR-proADM with short- and long-term mortality and hospital admission for heart failure in patients with ST-segment-elevation myocardial infarction. Outcomes were assessed using Cox proportional hazard models and area under the curve using receiver operating characteristics. In total, 1122 patients were included. The median concentration of MR-proADM was 0.64 nmol/L (25th-75th percentiles, 0.53-0.79). Within 30 days 23 patients (2.0%) died and during a 3-year follow-up 80 (7.1%) died and 38 (3.4%) were admitted for heart failure. A doubling of MR-proADM was, in adjusted models, associated with an increased risk of 30-day mortality (hazard ratio, 2.67; 95% confidence interval, 1.01-7.11; P=0.049), long-term mortality (hazard ratio, 3.23; 95% confidence interval, 1.97-5.29; P<0.0001), and heart failure (hazard ratio, 2.71; 95% confidence interval, 1.32-5.58; P=0.007). For 30-day and 3-year mortality, the area under the curve for MR-proADM was 0.77 and 0.78, respectively. For 3-year mortality, area under the curve (0.84) of the adjusted model marginally changed (0.85; P=0.02) after addition of MR-proADM.CONCLUSIONS: Elevation of admission MR-proADM was associated with long-term mortality and heart failure, whereas the association with short-term mortality was borderline significant. MR-proADM may be a marker of prognosis after ST-segment-elevation myocardial infarction but does not seem to add substantial prognostic information to established clinical models.CLINICAL TRIAL REGI

Published
2018

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