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3. Outcomes and factors associated with relapse of vaccine-induced liver injury after SARS CoV-2 immunization: A nationwide study

Author

Barreira-Díaz, Ana, Riveiro-Barciela, Mar, Fernández-Bonilla, Eva María, Bernal, Vanesa, Castiella, Agustín, Casado-Martín, Marta, Delgado, Carolina, Londoño, María-Carlota, Díaz-González, Álvaro, Pérez-Medrano, Indhira, Conthe, Andrés, Sala, Margarita, Mateos, Beatriz, Gómez-Camarero, Judith, Antón-Conejero, Dolores, Pozo-Calzada, Carmen Del, Cuenca, Francisca, Villagrasa-Vilella, Ares, and Salcedo, Magdalena

Published
2024
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4. Assessing the impact of COVID-19 on liver cancer management (CERO-19)

Author

Muñoz-Martínez, Sergio, Sapena, Victor, Forner, Alejandro, Nault, Jean-Charles, Sapisochin, Gonzalo, Rimassa, Lorenza, Sangro, Bruno, Bruix, Jordi, Sanduzzi-Zamparelli, Marco, Hołówko, Wacław, El Kassas, Mohamed, Mocan, Tudor, Bouattour, Mohamed, Merle, Philippe, Hoogwater, Frederik J.H., Alqahtani, Saleh A., Reeves, Helen L., Pinato, David J., Giorgakis, Emmanouil, Meyer, Tim, Villadsen, Gerda Elisabeth, Wege, Henning, Salati, Massimiliano, Mínguez, Beatriz, Di Costanzo, Giovan Giuseppe, Roderburg, Christoph, Tacke, Frank, Varela, María, Galle, Peter R., Alvares-da-Silva, Mario Reis, Trojan, Jörg, Bridgewater, John, Cabibbo, Giuseppe, Toso, Christian, Lachenmayer, Anja, Casadei-Gardini, Andrea, Toyoda, Hidenori, Lüdde, Tom, Villani, Rosanna, Matilla Peña, Ana María, Guedes Leal, Cassia Regina, Ronzoni, Monica, Delgado, Manuel, Perelló, Christie, Pascual, Sonia, Lledó, José Luis, Argemi, Josepmaria, Basu, Bristi, da Fonseca, Leonardo, Acevedo, Juan, Siebenhüner, Alexander R., Braconi, Chiara, Meyers, Brandon M., Granito, Alessandro, Sala, Margarita, Rodríguez-Lope, Carlos, Blaise, Lorraine, Romero-Gómez, Manuel, Piñero, Federico, Gomez, Dhanny, Mello, Vivianne, Pinheiro Alves, Rogerio Camargo, França, Alex, Branco, Fernanda, Brandi, Giovanni, Pereira, Gustavo, Coll, Susanna, Guarino, Maria, Benítez, Carlos, Anders, Maria Margarita, Bandi, Juan C., Vergara, Mercedes, Calvo, Mariona, Peck-Radosavljevic, Markus, García-Juárez, Ignacio, Cardinale, Vincenzo, Lozano, Mar, Gambato, Martina, Okolicsanyi, Stefano, Morales-Arraez, Dalia, Elvevi, Alessandra, Muñoz, Alberto E., Lué, Alberto, Iavarone, Massimo, and Reig, Maria

Published
2021
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5. Translating self-persuasion into an adolescent HPV vaccine promotion intervention for parents attending safety-net clinics

Author

Baldwin, Austin S, Denman, Deanna C, Sala, Margarita, Marks, Emily G, Shay, L Aubree, Fuller, Sobha, Persaud, Donna, Lee, Simon Craddock, Skinner, Celette Sugg, Wiebe, Deborah J, and Tiro, Jasmin A

Subjects
Health Services and Systems, Health Sciences, Immunization, Vaccine Related, Pediatric, Clinical Trials and Supportive Activities, Cancer, Prevention, HPV and/or Cervical Cancer Vaccines, Adolescent Sexual Activity, Infectious Diseases, Sexually Transmitted Infections, Clinical Research, HIV/AIDS, Behavioral and Social Science, 3.4 Vaccines, Prevention of disease and conditions, and promotion of well-being, Adolescent, Adult, Feasibility Studies, Female, Health Knowledge, Attitudes, Practice, Health Promotion, Humans, Interviews as Topic, Male, Middle Aged, Papillomavirus Infections, Papillomavirus Vaccines, Parents, Patient Acceptance of Health Care, Persuasive Communication, Qualitative Research, Safety-net Providers, Vaccination, Medical and Health Sciences, Psychology and Cognitive Sciences, Public Health, Health services and systems
Abstract

ObjectiveSelf-persuasion is an effective behavior change strategy, but has not been translated for low-income, less educated, uninsured populations attending safety-net clinics or to promote human papillomavirus (HPV) vaccination. We developed a tablet-based application (in English and Spanish) to elicit parental self-persuasion for adolescent HPV vaccination and evaluated its feasibility in a safety-net population.MethodsParents (N=45) of age-eligible adolescents used the self-persuasion application. Then, during cognitive interviews, staff gathered quantitative and qualitative feedback on the self-persuasion tasks including parental decision stage.ResultsThe self-persuasion tasks were rated as easy to complete and helpful. We identified six question prompts rated as uniformly helpful, not difficult to answer, and generated non-redundant responses from participants. Among the 33 parents with unvaccinated adolescents, 27 (81.8%) reported deciding to get their adolescent vaccinated after completing the self-persuasion tasks.ConclusionsThe self-persuasion application was feasible and resulted in a change in parents' decision stage. Future studies can now test the efficacy of the tablet-based application on HPV vaccination.Practice implicationsThe self-persuasion application facilitates verbalization of reasons for HPV vaccination in low literacy, safety-net settings. This self-administered application has the potential to be more easily incorporated into clinical practice than other patient education approaches.

Published
2017

7. Development and initial testing of mindful journey: a digital mindfulness-based intervention for promoting recovery from Substance use disorder.

Author

Roos, Corey R., Kiluk, Brian, Carroll, Kathleen M., Bricker, Jonathan B., Chung Jung Mun, Sala, Margarita, Kirouac, Megan, Stein, Elena, John, Maya, Palmer, Robert, DeBenedictis, Andrew, Frisbie, Jena, Haeny, Angela M., Barry, Declan, Fucito, Lisa M., Bowen, Sarah, Witkiewitz, Katie, and Kober, Hedy

Subjects
MINDFULNESS, DIGITAL music, GROUP psychotherapy, SUBSTANCE abuse, MOBILE apps
Abstract

Background/Objectives: There is a great unmet need for accessible adjunctive interventions to promote long-term recovery from substance use disorder (SUD). This study aimed to iteratively develop and test the initial feasibility and acceptability of Mindful Journey, a novel digital mindfulness-based intervention for promoting recovery among individuals with SUD. Patients/Materials: Ten adults receiving outpatient treatment for SUD. Methods: Phase 1 (n=5) involved developing and testing a single introductory digital lesson. Phase 2 included a separate sample (n=5) and involved testing all 15 digital lessons (each 30- to 45-minutes) over a 6-week period, while also receiving weekly brief phone coaching for motivational/technical support. Results: Across both phases, quantitative ratings (rated on a 5-point scale) were all at or above a 4 (corresponding with 'agree') for key acceptability dimensions, such as usability, understandability, appeal of visual content, how engaging the content was, and helpfulness for recovery. Additionally, in both phases, qualitative feedback indicated that participants particularly appreciated the BOAT (Breath, Observe, Accept, Take a Moment) tool for breaking down mindfulness into steps. Qualitative feedback was used to iteratively refine the intervention. For example, based on feedback, we added a second core mindfulness tool, the SOAK (Stop, Observe, Appreciate, Keep Curious), and we added more example clients and group therapy videos. In Phase 2, 4 out of 5 participants completed all 15 lessons, providing initial evidence of feasibility. Participants reported that the phone coaching motivated them to use the app. The final version of Mindful Journey was a smartphone app with additional features, including brief on-the-go audio exercises and a library of mindfulness practices. Although, participants used these additional features infrequently. Conclusions: Based on promising initial findings, future acceptability and feasibility testing in a larger sample is warranted. Future versions might include push notifications to facilitate engagement in the additional app features. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Time association between hepatitis C therapy and hepatocellular carcinoma emergence in cirrhosis: Relevance of non-characterized nodules

Author

Mariño, Zoe, Darnell, Anna, Lens, Sabela, Sapena, Victor, Díaz, Alba, Belmonte, Ernest, Perelló, Christie, Calleja, Jose Luis, Varela, Maria, Rodriguez, Manuel, Rodriguez de Lope, Carlos, Llerena, Susana, Torras, Xavier, Gallego, Adolfo, Sala, Margarita, Morillas, Rosa María, Minguez, Beatriz, Llaneras, Jordi, Coll, Susana, Carrion, José Antonio, Iñarrairaegui, Mercedes, Sangro, Bruno, Vilana, Ramón, Sole, Manel, Ayuso, Carmen, Ríos, José, Forns, Xavier, Bruix, Jordi, and Reig, María

Published
2019
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17. Impact of the metabolic profile on the response to ursodeoxycholic acid in patients with primary biliary cholangitis: results of the ColHai registry

Author

Gonzalez, Alvaro Diaz, primary, Pascual, Andrea González, additional, Gómez-Camarero, Judith, additional, Domínguez, Elena Gómez, additional, Londoño, Maria Carlota, additional, Gómez, Mercedes Vergara, additional, Ampuero, Javier, additional, Martinez, Javier, additional, Horta, Diana, additional, Gallego, Adolgo, additional, Salmerón, Javier, additional, García-Retortillo, Montserrat, additional, Morillas, Rosa M., additional, Andrade, Raul J., additional, Turnes, Juan, additional, Diago, Moises, additional, El Hajra Martínez, Ismael, additional, Alemany, Merce Roget, additional, Guerra, Manuel Hernández, additional, Quintans, Nerea, additional, Sala, Margarita, additional, Dominguez, Nuria, additional, Almeida, Ana Arencibia, additional, Crespo, Javier, additional, Barreira, Ana, additional, Salcedo, Magdalena, additional, and Barciela, Mar Riveiro, additional

Published
2023
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20. Incidence, risk factors and clinical outcomes of multidrug-resistant microorganism infections among patients admitted for decompensated cirrhosis: A prospective study

Author

Masnou, Helena, primary, Aguilar, Ariadna, additional, Iborra, Ignacio, additional, Sala, Margarita, additional, Torner, Maria, additional, Clos-Parals, Ariadna, additional, Ardèvol, Alba, additional, Giménez, Montserrat, additional, Fortuny, Marta, additional, Sarrias, Maria Rosa, additional, Morillas, Rosa M., additional, and Domènech, Eugeni, additional

Published
2023
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26. Incidence, risk factors and clinical outcomes of multidrug-resistant microorganism infections among patients admitted for decompensated cirrhosis: A prospective study

Author

Masnou, Helena, primary, Aguilar, Ariadna, additional, Iborra, Ignacio, additional, Sala, Margarita, additional, Torner, Maria, additional, Clos-Parals, Ariadna, additional, Ardèvol, Alba, additional, Giménez, Montserrat, additional, Fortuny, Marta, additional, Sarrias, Maria Rosa, additional, Morillas, Rosa M., additional, and Domènech, Eugeni, additional

Published
2022
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27. Abstract PO010: Molecular characterization of pediatric hepatocellular carcinoma: genomic, methylomic and transcriptomic analysis

Author

Carrillo-Reixach, Juan, primary, del Río-Álvarez, Álvaro, additional, Royo, Laura, additional, Domingo-Sàbat, Montserrat, additional, Alaggio, Rita, additional, de Krijger, Ronald, additional, Vokuhl, Christian, additional, Garrido, Marta, additional, Guerra, Laura, additional, Sábado, Constantino, additional, Hernández, Francisco, additional, López-Santamaría, Manuel, additional, Bajčiová, Viera, additional, Maibach, Rudolf, additional, Childs, Margaret, additional, Czauderna, Piotr, additional, Wheatley, Keith, additional, Kappler, Roland, additional, Cairo, Stefano, additional, Morland, Bruce, additional, Sala, Margarita, additional, Sarrias, Maria Rosa, additional, and Armengol, Carolina, additional

Published
2022
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28. Complete response under sorafenib in patients with hepatocellular carcinoma: Relationship with dermatologic adverse events

Author

Rimola, Jordi, Díaz‐González, Álvaro, Darnell, Anna, Varela, María, Pons, Fernando, Hernandez‐Guerra, Manuel, Delgado, Manuel, Castroagudin, Javier, Matilla, Ana, Sangro, Bruno, Rodriguez de Lope, Carlos, Sala, Margarita, Gonzalez, Carmen, Huertas, Carlos, Minguez, Beatriz, Ayuso, Carmen, Bruix, Jordi, and Reig, María

Published
2018
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30. Outcome of liver cancer patients with SARS‐CoV‐2 infection: an international, multicentre, cohort study

Author

Muñoz- Martínez, Sergio, Sapena, Victor, Forner, Alejandro, Bruix, Jordi, Sanduzzi-Zamparelli, Marco, Ríos, José, Bouattour, Mohamed, El Kassas, Mohamed, Guedes Leal, Cassia Regina, Mocan, Tudor, Nault, Jean-Charles, Camargo Pinheiro Alves, Rogerio, Reeves, Helen L., da Fonseca, Leonardo, García-Juárez, Ignacio, Pinato, David J., Varela, María, Alqahtani, Saleh A., Alvares-da-Silva, Mario Reis, Bandi, Juan C., Rimassa, Lorenza, Lozano, Mar, González Santiago, Jesús M., Tacke, Frank, Sala, Margarita, Anders, Maria Margarita, Lachenmayer, Anja, Piñero, Federico, França, Alex, Guarino, María, Elvevi, Alessandra, Cabibbo, Giuseppe, Peck-Radosavljevic, Markus, Rojas, Ángela, Vergara, Mercedes, Braconi, Chiara, Pascual, Sonia, Perelló, Christie, Mello, Vivianne, Rodríguez-Lope, Carlos, Acevedo, Juan, Villani, Rosanna, Hollande, Clemence, Vilgrain, Valérie, Tawheed, Ahmed, Ferguson Theodoro, Carmem, Sparchez, Zeno, Blaise, Lorraine, Viera-Alves, Daniele E., Watson, Robyn, Carrilho, Flair J., Moctezuma-Velázquez, Carlos, D'Alessio, Antonio, Iavarone, Massimo, Reig, María, Ministerio de Sanidad (España), European Association for the Study of the Liver, Cancer Treatment and Research Trust, Wellcome Trust, Cancer Research UK, Instituto de Salud Carlos III, Bristol Myers Squibb Foundation, Muñoz- Martínez, Sergio [0000-0003-0663-0575], Sapena, Victor [0000-0003-4379-6486], Forner, Alejandro [0000-0002-9014-4950], Ríos, José [0000-0002-0716-8784], González Santiago, Jesús M. [0000-0003-4667-4492], Rojas, Ángela [0000-0003-0853-4800], Hollande, Clemence [0000-0002-2287-0635], Muñoz- Martínez, Sergio, Sapena, Victor, Forner, Alejandro, Ríos, José, González Santiago, Jesús M., Rojas, Ángela, Hollande, Clemence, and Sergio Muñoz-Martínez, Victor Sapena, Alejandro Forner, Jordi Bruix, Marco Sanduzzi-Zamparelli, José Ríos, Mohamed Bouattour, Mohamed El-Kassas, Cassia R. G. Leal, Tudor Mocan, Jean-Charles Nault, Rogerio C. P. Alves, Helen L. Reeves, Leonardo da Fonseca, Ignacio García-Juárez, David J. Pinato, María Varela, Saleh A. Alqahtani, Mario R. Alvares-da-Silva, Juan C. Bandi, Lorenza Rimassa, Mar Lozano, Jesús M. González Santiago, Frank Tacke, Margarita Sala, María Anders, Anja Lachenmayer, Federico Piñero, Alex França, Maria Guarino, Alessandra Elvevi, Giuseppe Cabibbo, Markus Peck-Radosavljevic, Ángela Rojas, Mercedes Vergara, Chiara Braconi, Sonia Pascual, Christie Perelló, Vivianne Mello, Carlos Rodríguez-Lope, Juan Acevedo, Rosanna Villani, Clemence Hollande, Valérie Vilgrain, Ahmed Tawheed, Carmem Ferguson Theodoro, Zeno Sparchez, Lorraine Blaise, Daniele E. Viera-Alves, Robyn Watson, Flair J. Carrilho, Carlos Moctezuma-Velázquez, Antonio D'Alessio, Massimo Iavarone, Maria Reig

Subjects
Settore MED/12 - Gastroenterologia, Carcinoma, Hepatocellular, Hepatology, Hepatocellular carcinoma, SARS-CoV-2, Liver Neoplasms, COVID-19, hepatocellular carcinoma, mortality, Cohort Studies, liver cancer, COVID-19 Testing, Cross-Sectional Studies, Humans, Mortality, Liver cancer, Retrospective Studies
Abstract

Background & Aims Information about the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients with liver cancer is lacking. This study characterizes the outcomes and mortality risk in this population. Methods Multicentre retrospective, cross-sectional, international study of liver cancer patients with SARS-CoV-2 infection registered between February and December 2020. Clinical data at SARS-CoV-2 diagnosis and outcomes were registered. Results Two hundred fifty patients from 38 centres were included, 218 with hepatocellular carcinoma (HCC) and 32 with intrahepatic cholangiocarcinoma (iCCA). The median age was 66.5 and 64.5 years, and 84.9% and 21.9% had cirrhosis in the HCC and iCCA cohorts respectively. Patients had advanced cancer stage at SARS-CoV-2 diagnosis in 39.0% of the HCC and 71.9% of the iCCA patients. After a median follow-up of 7.20 (IQR: 1.84–11.24) months, 100 (40%) patients have died, 48% of the deaths were SARS-CoV-2-related. Forty (18.4%) HCC patients died within 30-days. The death rate increase was significantly different according to the BCLC stage (6.10% [95% CI 2.24–12.74], 11.76% [95% CI 4.73–22.30], 20.69% [95% CI 11.35–31.96] and 34.52% [95% CI 17.03–52.78] for BCLC 0/A, B, C and D, respectively; p = .0017). The hazard ratio was 1.45 (95% CI 0.49–4.31; p = .5032) in BCLC-B versus 0/A, and 3.13 (95% CI 1.29–7.62; p = .0118) in BCLC-C versus 0/A in the competing risk Cox regression model. Nineteen out of 32 iCCA (59.4%) died, and 12 deaths were related to SARS-CoV-2 infection. Conclusions This is the largest cohort of liver cancer patients infected with SARS-CoV-2. It characterizes the 30-day mortality risk of SARS-CoV-2 infected patients with HCC during this period., Spanish Health Ministry; Ricerca Corrente, Grant/Award Number: RC2019/105-01, RC2018/105-01 and RC2017/105-01; European Association for the Study of the Liver (Andrew Burroughs Fellowship); Cancer Treatment and Research Trust (CTRT); Wellcome Trust Strategic Fund, Grant/Award Number: PS3416; Cancer Research UK (CR UK) centre, Grant/Award Number: C9380/A26813, C18342/A23390 and C9380/A18084; Instituto de Salud Carlos III, Grant/Award Number: PI18/0358, PI15/00145, CD18/00126, PI19/00819, FI19/00222, 16-0026, PI044031, PI18/00768, PI18/00542 and PI13/01229; Bristol Myers Squibb and Celgene; Cancer Research UK, Grant/Award Number: RCCPDB-Nov21/100008

Published
2022

31. Outcome of liver cancer patients with SARS-CoV-2 infection

Author

Muñoz-Martínez, Sergio, Sapena, Victor, Forner, Alejandro, Bruix, Jordi, Sanduzzi-Zamparelli, Marco, Ríos, José, Bouattour, Mohamed, El Kassas, Mohamed, Leal, Cassia Regina Guedes, Mocan, Tudor, Nault, Jean-Charles, Alves, Rogerio Camargo Pinheiro, Reeves, Helen L, da Fonseca, Leonardo, García-Juárez, Ignacio, Pinato, David J, Varela, María, Alqahtani, Saleh A, Alvares-da-Silva, Mario Reis, Bandi, Juan C, Rimassa, Lorenza, Lozano, Mar, González Santiago, Jesús Manuel, Tacke, Frank, Sala, Margarita, Anders, María, Lachenmayer, Anja, Piñero, Federico, França, Alex, Guarino, Maria, Elvevi, Alessandra, Cabibbo, Giuseppe, Peck-Radosavljevic, Markus, Rojas, Ángela, Vergara, Mercedes, Braconi, Chiara, Pascual, Sonia, Perelló, Christie, Mello, Vivianne, Rodríguez-Lope, Carlos, Acevedo, Juan, Villani, Rosanna, Hollande, Clemence, Vilgrain, Valérie, Tawheed, Ahmed, Ferguson Theodoro, Carmem, Sparchez, Zeno, Blaise, Lorraine, Viera-Alves, Daniele Evaristo, Watson, Robyn, Carrilho, Flair José, Moctezuma-Velázquez, Carlos, D'Alessio, Antonio, Iavarone, Massimo, and Reig, Maria

Subjects
610 Medicine & health
Abstract

BACKGROUND & AIMS Information about the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients with liver cancer is lacking. This study characterizes the outcomes and mortality risk in this population. METHODS Multicenter retrospective, cross-sectional, international study of liver cancer patients with SARS-CoV-2 infection registered between February-December 2020. Clinical data at SARS-CoV-2 diagnosis and outcomes were registered. RESULTS Two-hundred-fifty patients from 38 centers were included, 218 with hepatocellular carcinoma (HCC), 32 with intrahepatic cholangiocarcinoma (iCCA). Median age was 66.5 and 64.5 years, and 84.9% and 21.9% had cirrhosis in the HCC and iCCA cohorts, respectively. Patients had advanced cancer stage at SARS-CoV-2 diagnosis in 39.0% of the HCC and 71.9% of the iCCA patients. After a median follow-up of 7.20 [IQR:1.84-11.24] months, 100 (40%) patients have died,48% of the deaths were SARS-CoV-2-related. Forty (18.4%) HCC patients died within 30-days. The death rate increase was significantly different according to the BCLC stage [6.10%(95%CI 2.24-12.74), 11.76%(95%CI 4.73-22.30), 20.69%(95%CI 11.35-31.96), and 34.52%(95%CI 17.03-52.78) for BCLC 0/A, B, C and D respectively; p=0.0017]. The Hazard Ratio was 1.45 (95%CI 0.49-4.31; p=0.5032) in BCLC-B vs 0/A, and 3.13 (95%CI 1.29-7.62; p=0.0118) in BCLC-C vs 0/A in the Competing risk Cox regression model. Nineteen out of 32 iCCA (59.4%) died, 12 deaths related to SARS-CoV-2 infection. CONCLUSIONS This is the largest cohort of liver cancer patients infected with SARS-CoV-2. It characterizes the 30-day mortality risk of SARS-CoV-2 infected patients with HCC during this period.

Published
2022

33. A Description of Disordered Eating Behaviors in Latino Males

Author

Reyes-Rodriguez, Mae Lynn, Sala, Margarita, Von Holle, Ann, Unikel, Claudia, Bulik, Cynthia M., Camara-Fuentes, Luis, and Suarez-Torres, Alba

Abstract

Objective: To explore disordered eating and eating disorders (EDs) in Latino males. Participants: Participants are 722 male college students from a larger prevalence study conducted in the University of Puerto Rico system. Methods: Participants were selected from a list of sections of required courses for first-year students on each campus. Self-report instruments were used to explore ED symptoms (the Eating Attitudes Test [EAT-26] and the Bulimia Test-Revised [BULIT-26-R] and the Beck Depression Inventory depression (BDI). Results: Overall, 2.26% scored above the cut-off point on the BULIT-R and 5.08% score above the cut-off point on the EAT-26. Of the males, 4.43% reported sufficient frequency and severity to approximate DSM-IV criteria for bulimia nervosa. Depression symptomatology was found in those who scored above the cut-off point on both instruments of EDs. Conclusion: College health practitioners should be aware of disordered eating in Latino males and include them in efforts to detect disordered eating behaviors in college students. (Contains 3 tables.)

Published
2011
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34. Should we seek complete liver tests normalization in primary biliary cholangitis? Data from ColHai registry

Author

Díaz-González, Álvaro, primary, Rodriguez-Tajes, Sergio, additional, Gómez, Mercedes Vergara, additional, Fabrega, Emilio, additional, Gomez, Manuel Romero, additional, Albillos, Agustin, additional, Camarero, Judith Gómez-, additional, Horta, Diana, additional, Gallego, Adolgo, additional, Garcia-Retortillo, Montserrat, additional, Andrade, Raul J., additional, Diago, Moises, additional, Morillas, Rosa M, additional, Guerra, Manuel Hernández, additional, Aracil, Carlos Ferre, additional, Sala, Margarita, additional, Domínguez, Elena Gómez, additional, Berenguer, Marina, additional, and Londoño, Maria Carlota, additional

Published
2022
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35. Impact of sex and recurrence in the prognosis of alcoholic hepatitis

Author

Gratacós-Gines, Jordi, primary, Rodríguez, Manuel, additional, Giráldez-Gallego, Alvaro, additional, Cabezas, Joaquín, additional, Vázquez, Inmaculada Fernández, additional, Cots, Meritxell Ventura, additional, Horta, Diana, additional, Sánchez-Delgado, Jordi, additional, Acosta-López, Silvia, additional, Varasa, Tomás Artaza, additional, Marti-Aguado, David, additional, Monterde, Vanesa Bernal, additional, Martin-Mateos, Rosa, additional, Clemente, Ana, additional, Tejedor-Tejada, Javier, additional, Bandera, Jose Pinazo, additional, Sala, Margarita, additional, Badia-Aranda, Esther, additional, Sancho, Victoria Aguilera, additional, Tomé, Santiago, additional, Fernández-Rodríguez, Conrado, additional, Caballería, Joan, additional, and Pose, Elisa, additional

Published
2022
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37. Outcome of liver cancer patients with SARS-CoV-2 infection: An International, Multicentre, Cohort Study

Author

Ministerio de Sanidad (España), European Association for the Study of the Liver, Cancer Treatment and Research Trust, Wellcome Trust, Cancer Research UK, Instituto de Salud Carlos III, Bristol Myers Squibb Foundation, Muñoz- Martínez, Sergio [0000-0003-0663-0575], Sapena, Victor [0000-0003-4379-6486], Forner, Alejandro [0000-0002-9014-4950], Ríos, José [0000-0002-0716-8784], González Santiago, Jesús M. [0000-0003-4667-4492], Rojas, Ángela [0000-0003-0853-4800], Hollande, Clemence [0000-0002-2287-0635], Muñoz- Martínez, Sergio, Sapena, Victor, Forner, Alejandro, Bruix, Jordi, Sanduzzi-Zamparelli, Marco, Ríos, José, Bouattour, Mohamed, El Kassas, Mohamed, Guedes Leal, Cassia Regina, Mocan, Tudor, Nault, Jean-Charles, Camargo Pinheiro Alves, Rogerio, Reeves, Helen L., da Fonseca, Leonardo, García-Juárez, Ignacio, Pinato, David J., Varela, María, Alqahtani, Saleh A., Alvares-da-Silva, Mario Reis, Bandi, Juan C., Rimassa, Lorenza, Lozano, Mar, González Santiago, Jesús M., Tacke, Frank, Sala, Margarita, Anders, Maria Margarita, Lachenmayer, Anja, Piñero, Federico, França, Alex, Guarino, María, Elvevi, Alessandra, Cabibbo, Giuseppe, Peck-Radosavljevic, Markus, Rojas, Ángela, Vergara, Mercedes, Braconi, Chiara, Pascual, Sonia, Perelló, Christie, Mello, Vivianne, Rodríguez-Lope, Carlos, Acevedo, Juan, Villani, Rosanna, Hollande, Clemence, Vilgrain, Valérie, Tawheed, Ahmed, Ferguson Theodoro, Carmem, Sparchez, Zeno, Blaise, Lorraine, Viera-Alves, Daniele E., Watson, Robyn, Carrilho, Flair J., Moctezuma-Velázquez, Carlos, D'Alessio, Antonio, Iavarone, Massimo, Reig, María, Ministerio de Sanidad (España), European Association for the Study of the Liver, Cancer Treatment and Research Trust, Wellcome Trust, Cancer Research UK, Instituto de Salud Carlos III, Bristol Myers Squibb Foundation, Muñoz- Martínez, Sergio [0000-0003-0663-0575], Sapena, Victor [0000-0003-4379-6486], Forner, Alejandro [0000-0002-9014-4950], Ríos, José [0000-0002-0716-8784], González Santiago, Jesús M. [0000-0003-4667-4492], Rojas, Ángela [0000-0003-0853-4800], Hollande, Clemence [0000-0002-2287-0635], Muñoz- Martínez, Sergio, Sapena, Victor, Forner, Alejandro, Bruix, Jordi, Sanduzzi-Zamparelli, Marco, Ríos, José, Bouattour, Mohamed, El Kassas, Mohamed, Guedes Leal, Cassia Regina, Mocan, Tudor, Nault, Jean-Charles, Camargo Pinheiro Alves, Rogerio, Reeves, Helen L., da Fonseca, Leonardo, García-Juárez, Ignacio, Pinato, David J., Varela, María, Alqahtani, Saleh A., Alvares-da-Silva, Mario Reis, Bandi, Juan C., Rimassa, Lorenza, Lozano, Mar, González Santiago, Jesús M., Tacke, Frank, Sala, Margarita, Anders, Maria Margarita, Lachenmayer, Anja, Piñero, Federico, França, Alex, Guarino, María, Elvevi, Alessandra, Cabibbo, Giuseppe, Peck-Radosavljevic, Markus, Rojas, Ángela, Vergara, Mercedes, Braconi, Chiara, Pascual, Sonia, Perelló, Christie, Mello, Vivianne, Rodríguez-Lope, Carlos, Acevedo, Juan, Villani, Rosanna, Hollande, Clemence, Vilgrain, Valérie, Tawheed, Ahmed, Ferguson Theodoro, Carmem, Sparchez, Zeno, Blaise, Lorraine, Viera-Alves, Daniele E., Watson, Robyn, Carrilho, Flair J., Moctezuma-Velázquez, Carlos, D'Alessio, Antonio, Iavarone, Massimo, and Reig, María

Abstract

Background & Aims Information about the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients with liver cancer is lacking. This study characterizes the outcomes and mortality risk in this population. Methods Multicentre retrospective, cross-sectional, international study of liver cancer patients with SARS-CoV-2 infection registered between February and December 2020. Clinical data at SARS-CoV-2 diagnosis and outcomes were registered. Results Two hundred fifty patients from 38 centres were included, 218 with hepatocellular carcinoma (HCC) and 32 with intrahepatic cholangiocarcinoma (iCCA). The median age was 66.5 and 64.5 years, and 84.9% and 21.9% had cirrhosis in the HCC and iCCA cohorts respectively. Patients had advanced cancer stage at SARS-CoV-2 diagnosis in 39.0% of the HCC and 71.9% of the iCCA patients. After a median follow-up of 7.20 (IQR: 1.84–11.24) months, 100 (40%) patients have died, 48% of the deaths were SARS-CoV-2-related. Forty (18.4%) HCC patients died within 30-days. The death rate increase was significantly different according to the BCLC stage (6.10% [95% CI 2.24–12.74], 11.76% [95% CI 4.73–22.30], 20.69% [95% CI 11.35–31.96] and 34.52% [95% CI 17.03–52.78] for BCLC 0/A, B, C and D, respectively; p = .0017). The hazard ratio was 1.45 (95% CI 0.49–4.31; p = .5032) in BCLC-B versus 0/A, and 3.13 (95% CI 1.29–7.62; p = .0118) in BCLC-C versus 0/A in the competing risk Cox regression model. Nineteen out of 32 iCCA (59.4%) died, and 12 deaths were related to SARS-CoV-2 infection. Conclusions This is the largest cohort of liver cancer patients infected with SARS-CoV-2. It characterizes the 30-day mortality risk of SARS-CoV-2 infected patients with HCC during this period.

Published
2022

38. Effect of rifaximin on infections, acute‐on‐chronic liver failure and mortality in alcoholic hepatitis: A pilot study (RIFA‐AH)

Author

Jiménez, César, primary, Ventura‐Cots, Meritxell, additional, Sala, Margarita, additional, Calafat, Margalida, additional, Garcia‐Retortillo, Montserrat, additional, Cirera, Isabel, additional, Cañete, Nuria, additional, Soriano, Germán, additional, Poca, María, additional, Simón‐Talero, Macarena, additional, Altamirano, José, additional, Lucey, Michael, additional, Garcia‐Tsao, Guadalupe, additional, Brown, Robert S., additional, Schwabe, Robert F., additional, Verna, Elizabeth C., additional, Schnabl, Bernd, additional, Bosques‐Padilla, Francisco, additional, Mathurin, Philippe, additional, Caballería, Juan, additional, Louvet, Alexandre, additional, Shawcross, Debbie L., additional, Abraldes, Juan G., additional, Genescà, Joan, additional, Bataller, Ramon, additional, and Vargas, Víctor, additional

Published
2022
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41. Obeticholic Acid and Fibrates in Primary Biliary Cholangitis: Comparative Effects in a Multicentric Observational Study

Author

Reig, Anna, primary, Álvarez-Navascués, Carmen, additional, Vergara, Mercedes, additional, Gómez-Domínguez, Elena, additional, Gallego-Moya, Adolfo, additional, Pérez-Medrano, Indhira M., additional, Fábrega, Emilio, additional, Hernández-Guerra, Manuel, additional, Berenguer, Marina, additional, Estevez, Pamela, additional, Arencibia, Ana, additional, Morillas, Rosa M., additional, Horta, Diana, additional, Albillos, Agustín, additional, Casado, Marta, additional, De la Cruz, Gema, additional, Fernandez-Bonilla, Eva, additional, Molina, Esther, additional, Hijona, Lander, additional, Diago, Moises, additional, Fernández-Rodriguez, Conrado M., additional, González-Santiago, Jesús M., additional, Sala, Margarita, additional, Gómez-Camarero, Judith, additional, Romero-Gomez, Manuel, additional, Suárez, Francisco, additional, Vargas, Victor, additional, Ferre-Aracil, Carlos, additional, Andrade, Raúl J., additional, Chahri, Nadia, additional, and Parés, Albert, additional

Published
2021
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42. Rebleeding prophylaxis improves outcomes in patients with hepatocellular carcinoma. A multicenter case-control study

Author

Ripoll, Cristina, Genescà, Joan, Araujo, Isis K., Graupera, Isabel, Augustin, Salvador, Tejedor, Marta, Cirera, Isabel, Aracil, Carles, Sala, Margarita, Hernandez-Guerra, Manuel, Llop, Elba, Escorsell, Angels, Catalina, Maria Vega, Cañete, Nuria, Albillos, Agustin, Villanueva, Càndid, Abraldes, Juan G., Bañares, Rafael, and Bosch, Jaime

Published
2013
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43. WED-264 - Impact of the metabolic profile on the response to ursodeoxycholic acid in patients with primary biliary cholangitis: results of the ColHai registry

Author

Gonzalez, Alvaro Diaz, Pascual, Andrea González, Gómez-Camarero, Judith, Domínguez, Elena Gómez, Londoño, Maria Carlota, Gómez, Mercedes Vergara, Ampuero, Javier, Martinez, Javier, Horta, Diana, Gallego, Adolgo, Salmerón, Javier, García-Retortillo, Montserrat, Morillas, Rosa M., Andrade, Raul J., Turnes, Juan, Diago, Moises, El Hajra Martínez, Ismael, Alemany, Merce Roget, Guerra, Manuel Hernández, Quintans, Nerea, Sala, Margarita, Dominguez, Nuria, Almeida, Ana Arencibia, Crespo, Javier, Barreira, Ana, Salcedo, Magdalena, and Barciela, Mar Riveiro

Published
2023
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44. Corrigendum to “Time association between hepatitis C therapy and hepatocellular carcinoma emergence in cirrhosis: Relevance of non-characterized nodules” [J Hepatol (2019) 874–884]

Author

Mariño, Zoe, primary, Darnell, Anna, additional, Lens, Sabela, additional, Sapena, Victor, additional, Díaz, Alba, additional, Belmonte, Ernest, additional, Perelló, Christie, additional, Calleja, Jose Luis, additional, Varela, Maria, additional, Rodriguez, Manuel, additional, Rodriguez de Lope, Carlos, additional, Llerena, Susana, additional, Torras, Xavier, additional, Gallego, Adolfo, additional, Sala, Margarita, additional, Morillas, Rosa María, additional, Minguez, Beatriz, additional, Llaneras, Jordi, additional, Coll, Susana, additional, Carrion, José Antonio, additional, Iñarrairaegui, Mercedes, additional, Sangro, Bruno, additional, Vilana, Ramón, additional, Sole, Manel, additional, Ayuso, Carmen, additional, Ríos, José, additional, Forns, Xavier, additional, Bruix, Jordi, additional, and Reig, María, additional

Published
2021
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47. Comparative effects of second-line therapy with obeticholic acid or fibrates in primary biliary cholangitis patients

Author

Reig, Anna, primary, Álvarez-Navascués, Carmen, additional, Gómez, Mercedes Vergara, additional, Domińguez, Elena Gómez, additional, Moya, Adolfo Gallego, additional, Pérez-Medrano, Indhira, additional, Fábrega, Emilio, additional, Guerra, Manuel Hernández, additional, Haym, Marina Berenguer, additional, Estevez, Pamela, additional, Almeida, Ana Arencibia, additional, Morillas, Rosa, additional, Horta, Diana, additional, Albillos, Agustin, additional, Casado, Marta, additional, De la Cruz, Gemma, additional, Bonilla, Eva Fernandez, additional, Molina, Esther, additional, Hijona, Lander, additional, Diago, Moises, additional, Fernandez Rodriguez, Conrado Manuel, additional, González-Santiago, Jesús M., additional, Sala, Margarita, additional, Gómez-Camarero, Judith, additional, Gomez, Manuel Romero, additional, Suárez, Francisco, additional, Vargas Blasco, Vićtor Manuel, additional, Aracil, Carlos Ferre, additional, Andrade, Raul J., additional, Chahri, Nadia, additional, and Pares, Albert, additional

Published
2020
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48. Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications

Author

Carrillo-Reixach, Juan, primary, Torrens, Laura, additional, Simon-Coma, Marina, additional, Royo, Laura, additional, Domingo-Sàbat, Montserrat, additional, Abril-Fornaguera, Jordi, additional, Akers, Nicholas, additional, Sala, Margarita, additional, Ragull, Sonia, additional, Arnal, Magdalena, additional, Villalmanzo, Núria, additional, Cairo, Stefano, additional, Villanueva, Alberto, additional, Kappler, Roland, additional, Garrido, Marta, additional, Guerra, Laura, additional, Sábado, Constantino, additional, Guillén, Gabriela, additional, Mallo, Mar, additional, Piñeyro, David, additional, Vázquez-Vitali, María, additional, Kuchuk, Olga, additional, Mateos, María Elena, additional, Ramírez, Gema, additional, Santamaría, Manuel López, additional, Mozo, Yasmina, additional, Soriano, Aroa, additional, Grotzer, Michael, additional, Branchereau, Sophie, additional, de Andoin, Nagore García, additional, López-Ibor, Blanca, additional, López-Almaraz, Ricardo, additional, Salinas, José Antonio, additional, Torres, Bárbara, additional, Hernández, Francisco, additional, Uriz, José Javier, additional, Fabre, Monique, additional, Blanco, Julià, additional, Paris, Claudia, additional, Bajčiová, Viera, additional, Laureys, Geneviève, additional, Masnou, Helena, additional, Clos, Ariadna, additional, Belendez, Cristina, additional, Guettier, Catherine, additional, Sumoy, Lauro, additional, Planas, Ramón, additional, Jordà, Mireia, additional, Nonell, Lara, additional, Czauderna, Piotr, additional, Morland, Bruce, additional, Sia, Daniela, additional, Losic, Bojan, additional, Buendia, Marie Annick, additional, Sarrias, Maria Rosa, additional, Llovet, Josep M., additional, and Armengol, Carolina, additional

Published
2020
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49. International and multicenter real‐world study of sorafenib‐treated patients with hepatocellular carcinoma under dialysis

Author

Díaz‐González, Álvaro, primary, Sanduzzi‐Zamparelli, Marco, additional, Fonseca, Leonardo G., additional, Di Costanzo, Giovan G., additional, Alves, Rogerio, additional, Iavarone, Massimo, additional, Leal, Cassia, additional, Sacco, Rodolfo, additional, Matilla, Ana M., additional, Hernández‐Guerra, Manuel, additional, Aballay Soteras, Gabriel, additional, Wörns, Marcus‐Alexander, additional, Pinter, Matthias, additional, Varela, María, additional, Ladekarl, Morten, additional, Chagas, Aline L., additional, Mínguez, Beatriz, additional, Arenas, Juan I., additional, Granito, Alessandro, additional, Sánchez‐Torrijos, Yolanda, additional, Rojas, Ángela, additional, Rodríguez de Lope, Carlos, additional, Alvares‐da‐Silva, Mario R., additional, Pascual, Sonia, additional, Rimassa, Lorenza, additional, Lledó, José L., additional, Huertas, Carlos, additional, Sangro, Bruno, additional, Giannini, Edoardo G., additional, Delgado, Manuel, additional, Vergara, Mercedes, additional, Perelló, Christie, additional, Lue, Alberto, additional, Sala, Margarita, additional, Gallego, Adolfo, additional, Coll, Susanna, additional, Hernáez, Tania, additional, Piñero, Federico, additional, Pereira, Gustavo, additional, França, Alex, additional, Marín, Juan, additional, Anders, Margarita, additional, Mello, Vivianne, additional, Lozano, Mar, additional, Nault, Jean C., additional, Menéndez, Josemaría, additional, García Juárez, Ignacio, additional, Bruix, Jordi, additional, and Reig, María, additional

Published
2020
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