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168 results on '"Saïdi H"'

9. Douze obstacles au diagnostic précoce de la BPCO en France : analyse qualitative d’entretiens de patients, médecins généralistes et pneumologues (étude ABCD, Analysis of Barriers in COPD Diagnosis)

Author

Roucoux, G., primary, Scanferla, E., additional, Correia Dos Santos, A., additional, Delorme, M., additional, Fraticelli, L., additional, Martin, C., additional, Nocent Ejnaini, C., additional, Ozier, A., additional, Patout, M., additional, Renou, B., additional, Saïdi, H., additional, Sail, L., additional, Silberschmidt, J., additional, Zonca, C., additional, Le Rouzic, O., additional, and Zysman, M., additional

Published
2024
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26. Male Condoms and Circumcision

Author

Shapiro, Roger L., Kapiga, Saidi H., Essex, Max, editor, Mboup, Souleymane, editor, Kanki, Phyllis J., editor, Marlink, Richard G., editor, Tlou, Sheila D., editor, and Holme, Molly, editor

Published
2002
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30. Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

Author

NISC Comparative Sequencing Program, Wu, Xueling, Zhou, Tongqing, Zhu, Jiang, Zhang, Baoshan, Georgiev, Ivelin, Wang, Charlene, Chen, Xuejun, Longo, Nancy S., Louder, Mark, McKee, Krisha, O'Dell, Sijy, Perfetto, Stephen, Schmidt, Stephen D., Shi, Wei, Wu, Lan, Yang, Yongping, Yang, Zhi-Yong, Yang, Zhongjia, Zhang, Zhenhai, Bonsignori, Mattia, Crump, John A., Kapiga, Saidi H., Sam, Noel E., Haynes, Barton F., Simek, Melissa, Burton, Dennis R., Koff, Wayne C., Doria-Rose, Nicole A., Connors, Mark, Mullikin, James C., Nabel, Gary J., Roederer, Mario, Shapiro, Lawrence, Kwong, Peter D., and Mascola, John R.

Published
2011
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41. Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activity

Author

Alan S. Futran, Tao Lu, Katherine Amberg-Johnson, Jiayi Xu, Xiaoxiao Yang, Saidi He, Sarah Boyce, Jeffrey A. Bell, Robert Pelletier, Takao Suzuki, Xianhai Huang, Heng Qian, Liping Fang, Li Xing, Zhaowu Xu, Stephen E. Kurtz, Jeffrey W. Tyner, Wayne Tang, Tao Guo, Karen Akinsanya, David Madge, and Kristian K. Jensen

Subjects
Biochemistry, Cell biology, Cancer, Science
Abstract

Summary: The USP7 deubiquitinase regulates proteins involved in the cell cycle, DNA repair, and epigenetics and has been implicated in cancer progression. USP7 inhibition has been pursued for the development of anti-cancer therapies. Here, we describe the discovery of potent and specific USP7 inhibitors exemplified by FX1-5303. FX1-5303 was used as a chemical probe to study the USP7-mediated regulation of p53 signaling in cells. It demonstrates mechanistic differences compared to MDM2 antagonists, a related class of anti-tumor agents that act along the same pathway. FX1-5303 synergizes with the clinically approved BCL2 inhibitor venetoclax in acute myeloid leukemia (AML) cell lines and ex vivo patient samples and leads to strong tumor growth inhibition in in vivo mouse xenograft models of multiple myeloma and AML. This work introduces new USP7 inhibitors, differentiates their mechanism of action from MDM2 inhibition, and identifies specific opportunities for their use in the treatment of AML.

Published
2024
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50. Hypertension among adolescents in sub-Saharan Africa: a systematic review

Author

Mussa K. Nsanya, Rachel Abramson, Godfrey A. Kisigo, Andy Hickner, Elias C. Nyanza, Robert N. Peck, and Saidi H. Kapiga

Subjects
hypertension, blood pressure, risk factors, adolescents, sub-Saharan Africa, cardiovascular complications, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

IntroductionHypertension (HTN) among adolescents is common in high-income countries, and leads to increased premature cardiovascular diseases (CVD). In sub-Saharan Africa (SSA), the prevalence of HTN among adolescents, associated risk factors and CVD complications are not well-described. Such data is needed for planning public health programs to prevent premature CVD in SSA.MethodsWe systematically searched 5 databases (MEDLINE, Embase, Google Scholar, Web of Science, and African Index Medicus) from their establishment to December 2021. Key search terms were: adolescent, arterial hypertension, and names of the 48 countries in SSA. We used Covidence® to manage the search results. The review was registered in the Open Science Framework (OSF) https://osf.io/p5sbt/.ResultsWe identified 4,008 articles out of which we screened 3,088 abstracts, and reviewed 583 full-text articles. We finally included 92 articles that were published between 1968 to December 2021. The majority were cross-sectional studies (80%) and conducted in school settings (78%). The risk of bias was low for 59 studies (64.1%), moderate for 29 studies (31.5%), and high for 4 studies (4.3%). Overall, the prevalence of HTN varied widely from 0.18% to 34.0% with a median (IQR) of 5.5% (3.1%, 11.1%). It was relatively higher in studies using automated blood pressure (BP) devices, and in studies defining HTN using thresholds based on percentile BP distribution for one's height, age, and sex. In addition, the prevalence of HTN was significantly higher in studies from Southern Africa region of SSA and positively correlated with the year of publication. Across studies, traditional risk factors such as age, sex, body mass index, and physical inactivity, were commonly found to be associated with HTN. In contrast, non-traditional risk factors related to poverty and tropical diseases were rarely assessed. Only three studies investigated the CVD complications related to HTN in the study population.ConclusionThe prevalence of HTN among adolescents in SSA is high indicating that this is a major health problem. Data on non-traditional risk factors and complications are scarce. Longitudinal studies are needed to clearly define the rates, causes, and complications of HTN.Systematic Review Registrationhttps://osf.io/p5sbt/, identifier (10.17605/OSF.IO/P5SBT).

Published
2023
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