112 results on '"Ronsivalle, V"'
Search Results
2. Asymmetry index for the photogrammetric assessment of facial asymmetry
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Blasi, A., Nucera, R., Ronsivalle, V., Candida, E., Grippaudo, C., Blasi A., Grippaudo C. (ORCID:0000-0002-9499-0556), Blasi, A., Nucera, R., Ronsivalle, V., Candida, E., Grippaudo, C., Blasi A., and Grippaudo C. (ORCID:0000-0002-9499-0556)
- Abstract
Introduction: Facial asymmetry is common and can be clinically related to dental malocclusion, facial bone development, muscular imbalance, and soft tissues thickness, which should be assessed during diagnosis to choose proper treatment options. This study aimed to quantify the amount of symmetry/asymmetry in previously defined symmetrical and asymmetrical subjects, analyzing full-face 3-dimensional images. Methods: Seventy-six orthodontic patients’ 3-dimensional face images were obtained with the 3dMD Trio-system (Atlanta, Ga) and processed with the Geomagic Control (64-bit; 3D Systems, Rock Hill, SC) software. Patients were divided into symmetrical and asymmetrical groups through a surface-based technique. Sixteen facial landmarks were positioned, an asymmetry index was calculated for each landmark, and an evaluation diagram of facial asymmetry was created through the asymmetry index mean and standard deviation of symmetrical and asymmetrical landmarks. Results: The asymmetry index mean varied from 0.05 to 1.51 in the symmetrical group and from 0.05 to 2.84 in the asymmetrical group. This study suggests that landmarks located in the lower third of the face have a greater asymmetry index than other landmarks. Conclusions: The landmark-based technique does not exhibit statistically significant differences among asymmetrical and symmetrical patients for some landmarks. This approach provides useful information about the localization and the extension of asymmetry, in which bilateral landmarks showed a higher amount of asymmetry than median landmarks.
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- 2022
3. The Evolution of the Cephalometric Superimposition Techniques from the Beginning to the Digital Era: A Brief Descriptive Review
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Lo Giudice, A., primary, Ronsivalle, V., additional, Zappalà, G., additional, Leonardi, R., additional, Campagna, P., additional, Isola, G., additional, and Palazzo, G., additional
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- 2021
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4. Assessment of orbital volume and morphological changes after rapid maxillary expansion performed with tooth-bone and bone-borne devices. A retrospective study using surface-to surface matching technique
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Nicotra, C, Ronsivalle, V, Casella, F, Di Grazia, C, Isola, G, and Lo Giudice, A
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- 2020
5. Effectiveness of ibuprofen and celecoxib on the management of pain and postsurgical inflammatory sequelae following third molar surgery: a randomized, controlled clinical trial
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Polizzi, A, Ronsivalle, V, Santonocito, S, Ramaglia, L, Leonardi, R, Ferlito, S, and Isola, G
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- 2020
6. Enhancing the diagnosis of maxillary transverse discrepancy through 3-D technology and surface-to-surface superimposition. Description of the digital workflow with a documented case report
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Lo Giudice, A, Nucera, R, Ronsivalle, V, Di Grazia, C, Rugeri, M, and Quinzi, V
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Palatal Expansion Technique ,Surface-to-surface superimposition ,Maxilla ,Humans ,Female ,Digital work-flow ,Maxillary transverse discrepancy ,3-D technology ,Child ,Workflow ,Malocclusion - Abstract
Maxillary transverse discrepancy is often diagnosed in childhood. The evaluation of morphological characteristics of the maxilla is crucial for appropriate treatment of this condition, however conventional diagnostic method is based on visual inspection and transversal linear parameters. In this paper, we described a user-friendly diagnostic digital workflow based on the surface-to-surface analysis. We also described a case report.A 6-year-old female patient presenting mild transversal maxillary deficiency associated with functional posterior crossbite was treated by using maxillary removable appliance. In this respect, the appliance was designed in accordance to the morphological characteristics of the maxilla obtained by using the diagnostic digital work-flow and the maxillary surface-to-surface analysis.The present user-friendly diagnostic digital workflow based on surface-to-surface analysis helps clinicians to detect specific morphological characteristics of the maxilla, such as shape and area of asymmetry, in order to reach a comprehensive diagnosis and choose the correct biomechanics for treating the condition.
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- 2020
7. Comparison between additive and subtractive cad-cam technique to produce orthognathic surgical splints: A personalized approach
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Palazzo, G., Ronsivalle, V., Oteri, G., Giudice, A. L., Toro, C., Campagna, P., Patini, Romeo, Bocchieri, S., Bianchi, A., Isola, G., Patini R. (ORCID:0000-0001-7358-8763), Palazzo, G., Ronsivalle, V., Oteri, G., Giudice, A. L., Toro, C., Campagna, P., Patini, Romeo, Bocchieri, S., Bianchi, A., Isola, G., and Patini R. (ORCID:0000-0001-7358-8763)
- Abstract
The present study aimed to evaluate the accuracy of digitally designed surgical splints generated with milling technology (material subtractive procedure) and with 3D printing technology (material additive procedure) through a customized approach in the planning of surgical orthognathic splints. Cone beam computed tomography (CBCT) examinations and scanned dental models of 10 subjects who had required surgical treatment of skeletal malocclusion were included. Simulation of the orthognathic surgery was performed according to dento-skeletal and aesthetic characteristics of the subjects and the visual treatment objective (VTO), using Dolphin3D software (Dolphin Imaging, version 11.0, Chatsworth, CA, USA). Afterward, the Appliance Designer software (3Shape A/S, Copenhagen, Denmark) was used to digitally design the surgical splints that were generated twice using laser stereolithography technology (DWS 0.29D, DWS, Vicenza, Italy) and milling technology (Sirona inLab MC X5). Finally, each physical splint was digitalized using a desktop scanner (D500 3D, 3Shape A/S, Copenhagen, Denmark) in order to perform deviation analysis using the original project as a reference. The relative percentage of matching (trueness) was calculated (Geomagic Control X software (3D Systems, version 2018.1.1, 3D Systems, Rock Hill, SC, USA). An Independent Student’s t-test was used to statistically analyze the data. The milled splints showed a lower value of root to mean square (RMS) relative to the original project (0.20 mm ± 0.018) compared to the prototyped splints (0.31 ± 0.021) (p < 0.001). According to the present findings, surgical splints generated with milling technology present higher trueness compared with 3D printing technology.
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- 2020
8. Assessment of the accuracy of imaging software for 3D rendering of the upper airway, usable in orthodontic and craniofacial clinical settings
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Antonino Lo Giudice, Vincenzo Ronsivalle, Giorgio Gastaldi, Rosalia Leonardi, Lo Giudice, A., Ronsivalle, V., Gastaldi, G., and Leonardi, R.
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Imaging, Three-Dimensional ,Upper airway ,Cone-beam computed tomography ,Humans ,Reproducibility of Results ,OSAS ,Orthodontics ,Nose ,3D rendering ,Software - Abstract
Background Several semi-automatic software are available for the three-dimensional reconstruction of the airway from DICOM files. The aim of this study was to evaluate the accuracy of the segmentation of the upper airway testing four free source and one commercially available semi-automatic software. A total of 20 cone-beam computed tomography (CBCT) were selected to perform semi-automatic segmentation of the upper airway. The software tested were Invesalius, ITK-Snap, Dolphin 3D, 3D Slicer and Seg3D. The same upper airway models were manually segmented (Mimics software) and set as the gold standard (GS) reference of the investigation. A specific 3D imaging technology was used to perform the superimposition between the upper airway model obtained with semi-automatic software and the GS model, and to perform the surface-to-surface matching analysis. The accuracy of semi-automatic segmentation was evaluated calculating the volumetric mean differences (mean bias and limits of agreement) and the percentage of matching of the upper airway models compared to the manual segmentation (GS). Qualitative assessments were performed using color-coded maps. All data were statistically analyzed for software comparisons. Results Statistically significant differences were found in the volumetric dimensions of the upper airway models and in the matching percentage among the tested software (p 3; matching = 90.05%) followed by ITK-Snap (mean bias = − 2.52 cm3; matching = 84.44%), Seg 3D (mean bias = 3.21 cm3, matching = 87.36%), 3D Slicer (mean bias = − 4.77 cm3; matching = 82.08%) and Dolphin 3D (difference mean = − 6.06 cm3; matching = 78.26%). According to the color-coded map, the dis-matched area was mainly located at the most anterior nasal region of the airway. Volumetric data showed excellent inter-software reliability (GS vs semi-automatic software), with coefficient values ranging from 0.904 to 0.993, confirming proportional equivalence with manual segmentation. Conclusion Despite the excellent inter-software reliability, different semi-automatic segmentation algorithms could generate different patterns of inaccuracy error (underestimation/overestimation) of the upper airway models. Thus, is unreasonable to expect volumetric agreement among different software packages for the 3D rendering of the upper airway anatomy.
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- 2022
9. Therapeutic and Metagenomic Potential of the Biomolecular Therapies against Periodontitis and the Oral Microbiome: Current Evidence and Future Perspectives
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Simona Santonocito, Salvatore Ferlito, Alessandro Polizzi, Vincenzo Ronsivalle, Rossana Sclafani, Alessandra Valletta, Antonino Lo Giudice, Raffaele Cavalcanti, Gianrico Spagnuolo, Gaetano Isola, Santonocito, S., Ferlito, S., Polizzi, A., Ronsivalle, V., Sclafani, R., Valletta, A., Lo Giudice, A., Cavalcanti, R., Spagnuolo, G., and Isola, G.
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Periodontium ,microbial ,immunomodulation ,Catalysis ,antimicrobials ,biofilm ,Inorganic Chemistry ,adjuvant ,Humans ,host response ,periodontiti ,genetics ,Physical and Theoretical Chemistry ,metagenomic ,Molecular Biology ,periodontitis ,Spectroscopy ,therapy ,Microbiota ,Organic Chemistry ,General Medicine ,Computer Science Applications ,adjuvants ,Metagenome ,Dysbiosis ,antimicrobial ,Metagenomics ,genetic - Abstract
The principles of periodontal therapy are based on the control of microbial pathogens and host factors that contribute to biofilm dysbiosis, with the aim of modulating the progression of periodontitis and periodontal tissue destruction. It is currently known how differently each individual responds to periodontal treatment, depending on both the bacterial subtypes that make up the dysbiotic biofilm and interindividual variations in the host inflammatory response. This has allowed the current variety of approaches for the management of periodontitis to be updated by defining the goals of target strategies, which consist of reducing the periodontopathogenic microbial flora and/or modulating the host-mediated response. Therefore, this review aims to update the current variety of approaches for the management of periodontitis based on recent target therapies. Recently, encouraging results have been obtained from several studies exploring the effects of some targeted therapies in the medium- and long-term. Among the most promising target therapies analyzed and explored in this review include: cell-based periodontal regeneration, mediators against bone resorption, emdogain (EMD), platelet-rich plasma, and growth factors. The reviewed evidence supports the hypothesis that the therapeutic combination of epigenetic modifications of periodontal tissues, interacting with the dysbiotic biofilm, is a key step in significantly reducing the development and progression of disease in periodontal patients and improving the therapeutic response of periodontal patients. However, although studies indicate promising results, these need to be further expanded and studied to truly realize the benefits that targeted therapies could bring in the treatment of periodontitis.
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- 2022
10. One step before 3D printing-evaluation of imaging software accuracy for 3-dimensional analysis of the mandible: A comparative study using a surface-to-surface matching technique
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Antonino Lo Giudice, Gaetano Isola, Alessandra Lucchese, Simone Muraglie, Vincenzo Ronsivalle, Manuel O. Lagravère, Cristina Grippaudo, Giudice, A. L., Ronsivalle, V., Grippaudo, C., Lucchese, A., Muraglie, S., Lagravere, M. O., and Isola, G.
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Cone beam computed tomography ,lcsh:Technology ,Dental 3D rendering ,0302 clinical medicine ,Software ,Segmentation ,Models ,General Materials Science ,Accuracy ,lcsh:QC120-168.85 ,Mathematics ,accuracy ,dentistry ,Mandible ,scanner ,dental 3D scanner ,printing ,030220 oncology & carcinogenesis ,Printing ,lcsh:TK1-9971 ,dental 3D rendering ,Matching (statistics) ,Scanner ,Article ,Settore MED/28 - MALATTIE ODONTOSTOMATOLOGICHE ,models ,03 medical and health sciences ,segmentation ,3D biomaterials ,manufacturing ,Linear regression ,lcsh:Microscopy ,Dental 3D scanner ,lcsh:QH201-278.5 ,lcsh:T ,business.industry ,Pattern recognition ,030206 dentistry ,Gold standard (test) ,Manufacturing ,lcsh:TA1-2040 ,Dentistry ,lcsh:Descriptive and experimental mechanics ,lcsh:Electrical engineering. Electronics. Nuclear engineering ,Artificial intelligence ,lcsh:Engineering (General). Civil engineering (General) ,business - Abstract
The accuracy of 3D reconstructions of the craniomaxillofacial region using cone beam computed tomography (CBCT) is important for the morphological evaluation of specific anatomical structures. Moreover, an accurate segmentation process is fundamental for the physical reconstruction of the anatomy (3D printing) when a preliminary simulation of the therapy is required. In this regard, the objective of this study is to evaluate the accuracy of four different types of software for the semiautomatic segmentation of the mandibular jaw compared to manual segmentation, used as a gold standard. Twenty cone beam computed tomography (CBCT) with a manual approach (Mimics) and a semi-automatic approach (Invesalius, ITK-Snap, Dolphin 3D, Slicer 3D) were selected for the segmentation of the mandible in the present study. The accuracy of semi-automatic segmentation was evaluated: (1) by comparing the mandibular volumes obtained with semi-automatic 3D rendering and manual segmentation and (2) by deviation analysis between the two mandibular models. An analysis of variance (ANOVA) was used to evaluate differences in mandibular volumetric recordings and for a deviation analysis among the different software types used. Linear regression was also performed between manual and semi-automatic methods. No significant differences were found in the total volumes among the obtained 3D mandibular models (Mimics = 40.85 cm3, ITK-Snap = 40.81 cm3, Invesalius = 40.04 cm3, Dolphin 3D = 42.03 cm3, Slicer 3D = 40.58 cm3). High correlations were found between the semi-automatic segmentation and manual segmentation approach, with R coefficients ranging from 0,960 to 0,992. According to the deviation analysis, the mandibular models obtained with ITK-Snap showed the highest matching percentage (Tolerance A = 88.44%, Tolerance B = 97.30%), while those obtained with Dolphin 3D showed the lowest matching percentage (Tolerance A = 60.01%, Tolerance B = 87.76%) (p <, 0.05). Colour-coded maps showed that the area of greatest mismatch between semi-automatic and manual segmentation was the condylar region and the region proximate to the dental roots. Despite the fact that the semi-automatic segmentation of the mandible showed, in general, high reliability and high correlation with the manual segmentation, caution should be taken when evaluating the morphological and dimensional characteristics of the condyles either on CBCT-derived digital models or physical models (3D printing).
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- 2020
11. In-silico immunoinformatic vaccine design for Treponema denticola ergothionase.
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Rexlin JP, Manickavasagam J, Yadalam PK, Shrivastava D, Srivastava KC, Ronsivalle V, Cicciù M, and Minervini G
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Background: Treponema denticola, a well-studied oral spirochete, adheres, invades, and damages periodontal tissues - gram-negative, anaerobic Treponema denticola. In previous research, sub-gingival spirochetes have correlated positively with dental plaque score, pocket, and clinical attachment level measurements. Hence, the study aims to design an immunoinformatic vaccine using a reverse vaccinology approach against Treponema denticola ergothionase., Methods: Protein Data Bank provided the FASTA amino acid sequence of Treponema denticola. Antigenicity, toxicity, and stability of discovered T-cell epitopes were evaluated to develop 6S7Q B and A multiepitope vaccination design. The Vaccine's dual major histocompatibility complex (MHC I and II) binding epitopes were also predicted. The designed Vaccine's identified epitope sequence and secondary structure were then predicted and validated. Protein-protein interactions involving ergothionase and human beta-defensins were investigated using molecular docking., Results: The designed Vaccine had high antigenicity, toxicity, and stability. The Vaccine's three-dimensional structure demonstrated a significant association with beta-defensin. Its low binding energy score of -827.6 kcal/mol indicates that the immune system will respond favorably to the antigen., Conclusions: In this research, we employed immunoinformatic techniques to create a reverse vaccination effort to develop an in-silico vaccine.
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- 2024
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12. Accuracy of imaging software usable in clinical settings for 3D rendering of tooth structures.
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Ronsivalle V, Venezia P, Migliorati M, Grippaudo C, Barbato E, Nucci L, Isola G, Leonardi R, and Lo Giudice A
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- Humans, Image Processing, Computer-Assisted methods, Models, Dental, Reproducibility of Results, Imaging, Three-Dimensional, Software, Cone-Beam Computed Tomography, Tooth diagnostic imaging, Tooth anatomy & histology
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Aim: The aim of the present study was to evaluate the segmentation accuracy of the dentition by testing four open-source semi-automatic software programs., Materials and Methods: Twenty CBCT scans were selected to perform semi-automatic segmentation of the maxillary and mandibular dentition. The software programs tested were InVesalius, ITK-SNAP, 3D Slicer, and Seg3D. In addition, each tooth model was manually segmented using Mimics software; this was set as the gold standard (GS) reference of the investigation. A specific 3D imaging technology was used to perform the superimposition between the tooth models obtained with the semi-automatic software and the GS model as well as to perform the surface-to-surface matching analysis. The accuracy of semi-automatic segmentation was evaluated, calculating the volumetric mean differences (mean bias and limits of agreement) and the percentage of matching of the tooth models compared with the manual segmentation (GS). Qualitative assessments were performed using color-coded maps. All data were statistically analyzed to perform comparisons between the investigated software programs., Results: Statistically significant differences were found in the volumetric and matching percentage data (P 0.05). InVesalius was the most accurate software program for 3D rendering of the dentition, with a volumetric bias (Mimics software) ranging from 4.59 to 85.79 mm3, while ITK-SNAP showed the highest volumetric bias, ranging from 30.22 to 319.83 mm3. The mismatched area was mainly located at the radicular tooth region. The volumetric data showed excellent inter-software reliability, with coefficient values ranging from 0.951 to 0.997., Conclusion: Different semi-automatic software algorithms could generate different patterns of inaccuracy error in the segmentation of teeth.
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- 2024
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13. Diagnosis of odontogenic keratocysts and non-keratocysts using edge attention convolution neural network.
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Yakolli N, Shivanna DB, Rao RS, Patil S, Ronsivalle V, Cicciù M, and Minervini G
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Background: The study's objective was to develop an automated method for a histopathology recognition model for odontogenic keratocysts (OKC) and non-keratocyst (Non-KC) in jaw cyst sections stained with hematoxylin (H) and eosin (E) on a tiny bit of incisional biopsy prior to surgery., Methods: This hastens the speed and precision of diagnosis to patients. Also, navigates the clinicians with the therapeutic doctrine. To build such a system and to increase the accuracy of the existing models, the edge attention CNN model with Keras functional API was implemented which efficiently analyzes the texture information of the images. Approximately 2861 microscopic images at a 40X magnification were taken from 54 OKC, 23 Dentigerous cysts (DC), and 20 Radicular cysts., Results: The model was trained using both RGB and canny edge-detected images. The model gave a good accuracy of 96.8%, which is suitable for real-time. Histopathological images are better analyzed through textural features. The proposed edge attention CNN highlights the edges, making texture analysis more precise., Conclusions: The suggested method will work for OKC and Non-KC diagnosis automation systems. The use of a whole slide imaging scanner has the potential to increase accuracy and remove human bias.
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- 2024
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14. Three-dimensional analysis of the potency of Cocos nucifera in demineralizing the artificial enamel carious lesion: a micro-CT study.
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Balakrishnan N, Subramanian AK, Eswaramoorthy R, Angappan M, Ronsivalle V, Marrapodi MM, Cicciù M, and Minervini G
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Background: Herbal based ingredients form a more sustainable and effective means for management of ailments related to the human body. Previously plant-based extracts of Cocos nucifera had effective remineralization potential. Hence to identify the changes in enamel mineral density and volume during the remineralization procedure, this study was done with an aim of three-dimensional micro-CT analysis to identify the potency of Cocos nucifera in remineralizing the artificial enamel carious lesion. The aim of the present study was a three-dimensional micro-CT analysis to identify of the potency of Cocos nucifera in remineralizing the artificial enamel carious lesion., Methods: This is an in-vitro study, performed in a laboratory setting. Tooth slabs (N.=35) measuring 3×3×1.5 mm were prepared from extracted molar tooth. The prepared slabs were allotted to their respective groups by block randomization. Demineralization of the tooth slabs were done for a period of 72 hours. Following this the samples were washed with deionized water and remineralization was carried out for a period of 14 days. The groups tested were: 1) only remineralization solution(control); 2) 1: 1 lyophilized coconut (2.5 g LC in 25 mL remineralization solution); 3) 2:1 Lyophilized coconut (5 g LC in 25 mL remineralization solution); 4) 1:1 coconut milk (2.5 g CM in 25 mL remineralization solution); and 5) 2:1 coconut milk (2:1 CM - 5 g CM in 25 mL remineralization solution). Micro-CT scanning and analysis of the samples was performed postdemineralization and postremineralization procedure to evaluate the changes in the enamel volume and enamel mineral density. Within each of the five-group tested, the changes in the enamel volume and density before and after remineralization procedure was statistically analyzed using Paired t-test. One way ANOVA and Post-hoc Tukey test were done to analyze the intergroup statistical significance between the various treatment groups postremineralization procedure., Results: The mean difference of the enamel volume indicates that the control group showed the highest differences (-4.57±0.347) this was seconded by the 1:1 coconut milk, 1:1 lyophilized coconut and the lowest was noted in the 2:1 coconut milk group. The mean differences of the changes in the enamel mineral density between the demineralized and remineralized enamel surface indicates that 2:1 Coconut milk showed highest changes in the surface enamel postdemineralization (-22.32±5.37) and 1:1 coconut milk showed the least of the changes in the surface of the enamel (4.00±3.42)., Conclusions: Coconut extracts obtained from various extraction procedures showed quantitative increase in remineralization of artificially created enamel carious lesion. Further in-vitro studies could be done to the clinical efficiency of the same in oral environment.
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- 2024
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15. Applications of robot-assisted UV disinfection in dentistry.
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Mehta V, Pandya VS, Mathur A, Obulareddy VT, Ronsivalle V, Cicciù M, and Minervini G
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Maintaining a microbial-free environment in healthcare facilities is more widely recognized as an essential component of therapies to minimize transmission of viruses associated with healthcare sector. The global spread of COVID-19 and recent outbreaks have presented humanity with previously unheard-of challenges. The development of autonomous disinfection robots seems to be necessary given the urgent need for constant sterilization in the face of a labor shortage. Due to their automated and perceived cost advantages by eliminating cleaning staff, these robots are being advertised more and more as an easy solution to immediately disinfect rooms and operating areas. The use of these services lowers the danger of infection, and expense of traditional cleaning and, most significantly, builds trust and security in medical facilities. Currently, routine (manual) cleaning is not replaced by disinfection robots; rather, they may support it. Additional hospital and device design alterations are necessary to address the overshadowing (visibility) issue allowing Ultraviolet disinfectant (UV-D) robots move freely in the medical environment. More technical developments and clinical studies in a variety of hospitals are needed to overcome the current challenges and find ways to integrate this unique technology into hospitals now and in the future. Thus, we present a review that includes detailing all elements required for it to function, as well as both its advantages and disadvantages. To the best of our knowledge, very limited studies have collected an in- depth data on the sterilization effect using a disinfection robot in the field of dentistry. We believe that this data will work as a foundation in more advanced uses at diverse sites that require disinfection and will highlight unsolved challenges and potential research avenues for UV robot operational concerns in dental hospitals. The goal of this work is to offer a comprehensive manual for UV-D robots covering pertinent information on traditional Ultraviolet germicidal irradiation (UVGI) system along with advancements in UV-D robots and thereby focusing on in-depth application in medical and dental facilities.
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- 2024
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16. Tobacco smoking and its impact on pain intensity of temporomandibular disorders: A systematic review and metanalysis.
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Shetty AA, Almalki SA, Al Jameel AH, Gowdar IM, Ronsivalle V, Cicciù M, and Minervini G
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Background: Temporomandibular disorders (TMDs) encompass a spectrum of orofacial conditions characterised by pain and dysfunction in the temporomandibular joint and surrounding structures. Tobacco smoking has been posited as a potential factor influencing the prevalence and intensity of TMD. However, the nature and extent of this relationship remain unclear due to variations in study outcomes. This systematic review aimed to consolidate existing research findings to elucidate the association between tobacco smoking and TMD pain intensity., Methods: A comprehensive search of electronic databases was conducted to identify relevant studies published up to June 2023. Studies investigating the relationship between tobacco smoking and TMD pain were included. Data extraction was conducted by two reviewers. Quality assessment was performed using the New Castle-Ottawa scale. Review Manager 5.4 was used to quantitatively analyse the results., Results: The review included four studies employing similar TMD assessment techniques. All studies reported elevated TMD pain intensity among tobacco users, with non-smokers exhibiting lower pain intensity. The quality of the included studies was good. Meta-analytic results showed that TMD pain intensity was higher in the smokers group compared to the non-smokers group, with a weighted mean difference (WMD) of 0.65 (BPM) (95% CI: [0.10, 1.19], p = .02)., Conclusion: This systematic review provides a comprehensive synthesis of the existing literature on tobacco smoking and TMD symptoms. The findings underscore the multifaceted nature of the relationship between smoking and TMD pain, highlighting its clinical relevance and the need for tailored interventions. Further research is warranted to elucidate underlying mechanisms and potential moderating factors, contributing to a more nuanced understanding of this complex association., (© 2024 The Author(s). Journal of Oral Rehabilitation published by John Wiley & Sons Ltd.)
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- 2024
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17. Microbiological aspects of cancer progression: A systematic review conducted according to the PRISMA 2020 guidelines and the Cochrane Handbook for Systematic Reviews of Interventions.
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Minervini G, Shivakumar S, Ronsivalle V, Franco R, Cicciù M, and Marrapodi MM
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- Humans, Disease Progression, Gastrointestinal Microbiome, Colorectal Neoplasms microbiology, Colorectal Neoplasms therapy
- Abstract
The complex interplay between the gut microbiota, cancer treatments and patient characteristics has emerged as a significant area of research. This study sought to examine these relationships in the context of colorectal cancer (CRC).A comprehensive search of relevant studies was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. The studies included a variety of treatment modalities and microbiological parameters. A data extraction form, designed specifically for this review, was used to assess a range of variables across all studies.The analysis revealed a multifaceted interaction between the gut microbiota, genetic factors and treatment outcomes. Elderly patients with CRC frequently received single-agent chemotherapy, with outcomes that were comparable to those of younger patients. The presence of tumorigenic bacteria, including Escherichia coli and Bacteroides fragilis, was associated with early colon neoplasia. Additionally, an abundance of Fusobacterium spp. was observed in colonic adenomas, contributing to a pro-inflammatory environment. Although the FcγRIIIa-158 V/V genotype was associated with higher cetuximab-mediated antibodydependent cellular cytotoxicity (ADCC), no direct influence of FcγR polymorphisms on treatment response was noted. Furthermore, the combination of programmed cell death protein-1 (PD-1), BRAF and MEK inhibition showed favorable response rates. The gut microbiome, especially the presence of Fusobacterium spp., had a notable influence on the therapeutic response in CRC.These findings underscore the role of the gut microbiota and genetic factors in cancer treatment outcomes, emphasizing the potential of a holistic approach to cancer management. Future research should exploit these findings in order to develop microbiota-modulating strategies and personalized medicine approaches for the purpose of improving the efficacy of cancer treatment.
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- 2024
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18. Efficacy of hyaluronic acid in temporomandibular disorders evaluated with diagnostic criteria for temporomandibular disorders (DC/TMD).
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Kukreja P, Kukreja BJ, Marrapodi MM, Ronsivalle V, Cicciù M, and Minervini G
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Background: The study aimed to retrospectively assess the efficacy of hyaluronic acid (HA) in managing temporomandibular disorders (TMD) using the diagnostic criteria for temporomandibular disorders (DC/TMD). There has been an ongoing debate regarding the effectiveness of HA as a treatment option for TMD, which necessitated a thorough evaluation., Methods: The review adhered to PRISMA guidelines conducted across eight different databases, including PubMed, Embase, Web of Science, Cochrane Library, Scopus, ScienceDirect, PsycINFO and CINAHL. The selection criteria included studies that evaluated the efficacy of HA in TMD patients, utilised DC/TMD, and were published in English. Data extraction and quality assessment were performed independently by two reviewers. ROB-2 tool was employed to assess methodological quality of the assessed studies., Results: A total of 10 studies met the inclusion criteria. They demonstrated that HA was effective in improving various symptoms of TMD, such as pain, mouth opening and joint sounds over control group. But on the other end, platelet-rich plasma (PRP) was found to be better than HA intervention in alleviation of TMD symptoms. However, the degree of improvement varied across the studies. Some studies reported adverse effects, but these were typically minor and transient. Risk of bias assessment was low in all the included studies., Conclusion: The findings suggest that HA can be an effective treatment for TMD when evaluated with DC/TMD. However, the variation in effectiveness across studies indicates the need for individualised treatment planning and careful monitoring of adverse effects. Further research is needed to refine the treatment protocols and understand the long-term effectiveness and safety of HA in TMD management., (© 2024 The Author(s). Journal of Oral Rehabilitation published by John Wiley & Sons Ltd.)
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- 2024
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19. Different Uses of Conscious Sedation for Managing Dental Anxiety During Third-Molar Extraction: Clinical Evidence and State of the Art.
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Rosa A, Ronsivalle V, Fiorillo L, and Arcuri C
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Dental anxiety, linked to avoiding dental treatment and heightened medical and surgical risks, prompted this systematic review. The objective is to synthesize existing evidence on conscious sedation techniques employed for managing dental anxiety in patients scheduled for third molar extraction surgery, aiming to identify optimal approaches and address knowledge gaps. This systematic review followed the "Preferred Reporting Items for Systematic Reviews and Meta-Analyses" checklist and the population, investigation, comparation, outcome framework. The protocol still needs to be registered. A thorough search was conducted, incorporating MEDLINE/PubMed, EMBASE, SCOPUS, clinicaltrials.gov, and the Cochrane Database of Systematic Reviews until February 2024. Only randomized controlled trials were considered, following "Preferred Reporting Items for Systematic Reviews and Meta-Analyses" guidelines. The risk of bias was evaluated following the Cochrane Handbook for Systematic Reviews of Interventions. Eighteen randomized controlled trials involving 2081 patients were included. Certain factors limited the feasibility of a meaningful meta-analysis, leading to a narrative synthesis. Conscious sedation with virtual reality showed an association with improved dental anxiety in 4 studies. One study reported reduced cortisol levels with midazolam compared with a placebo, whereas another noted significant variations in perioperative renin levels with remifentanil versus placebo. This review reveals inconclusive and conflicting findings regarding the role of conscious sedation in managing dental anxiety during third molar extraction surgery. Persistent uncertainties arise due to a need for consistent, standardized outcome measures. Addressing these limitations in study design is crucial for future research., Competing Interests: The authors report no conflicts of interest., (Copyright © 2024 by Mutaz B. Habal, MD.)
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- 2024
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20. Elucidating hematological profile and electrolyte balance in oral cancer patients.
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Sundaravadivelu I, Renu K, Kavitha S, Priya VV, Gayathri R, Ronsivalle V, Cicciù M, and Minervini G
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- Humans, Male, Female, Middle Aged, Water-Electrolyte Balance physiology, Electrolytes blood, Electrolytes metabolism, Aged, Adult, Mouth Neoplasms blood
- Abstract
Background: Oral cancer is a serious health issue in both the developing and developed worlds, and it is one of the most common forms of cancer of the head and neck. In accordance with the 2017 World Health Organization classification, oral cancer can affect any part of the mouth, including the buccal mucosa, the front two-thirds of the tongue, the lip, the palate, the vestibule, the alveolus, the floor of the mouth, and the gingivae. Hematology and electrolyte balance have been proposed as tumor indicators and paths into cancer's genesis. Examining the patient's blood count and electrolyte levels in order to better understand their oral cancer., Methods: Electrolyte abnormalities are common in cancer patients and may be caused by the disease itself or by treatment. Hyponatremia is the most frequent electrolyte problem in cancer patients, and it is typically caused by the syndrome of improper ADH secretion. Although electrolyte problems are associated with a worse prognosis for cancer patients, timely and effective therapy has the potential to enhance both short- and long-term results and quality of life. Hematological tests on patients with oral cancer, including differential cell count, white blood cell count, and hemoglobin level., Results: Compared to healthy controls, oral cancer patients show statistically significant differences in a number of biochemical parameters, including electrolytes (sodium, P<0.05; potassium, P=0.89; chloride, P<0.05); differential count (neutrophils, P<0.05; basophils, P<0.05). A significant risk factor for cancer patients is an electrolyte imbalance, which has been linked to inappropriate anti-diabetic hormone release., Conclusions: Clinicians will find these shifts in electrolytic level helpful in diagnosing and tracking oral cancer. Potentially malignant oral disorders and Oral squamous cell carcinoma may be better predicted using a combination of TLC, neutrophil, and lymphocyte counts, as shown in this study.
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- 2024
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21. Lessons to be learned when designing comprehensible patient-oriented online information about temporomandibular disorders.
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Uzunçıbuk H, Marrapodi MM, Ronsivalle V, Cicciù M, and Minervini G
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Background: Temporomandibular disorders (TMD) are a prevalent ailment with a global impact, affecting a substantial number of individuals. While some individuals are receiving treatment from orthodontists for TMD, a significant proportion of individuals obtain knowledge through websites., Objectives: Our purpose had been to evaluate, from a patient-oriented perspective, the readability of home pages of websites scored in the 10 most prominent devoted to TMD. We also determined what level of education would have been needed to get an overview of the information on the websites under scrutiny. This approach ensures that our findings are centred on the patient experience, providing insights into how accessible and understandable websites about TMD., Methods: We determined the top 10 patient-focused English language websites by searching for 'temporomandibular disorders' in the 'no country redirect' plugin of the Google Chrome browser (www.google.com/ncr). The readability of the texts was assessed using the Gunning fog index (GFI), Coleman Liau index (CLI), Automated readability index (ARI) Simple Measure of Gobbledygook (SMOG), Flesch Kincald grade level (FKGL), Flesh reasing ease (FRE) (https://readabilityformulas.com)., Results: The mean Flesch reading ease index score was determined to be 48.67, accompanied by a standard deviation of 15.04 and these websites require an average of 13.49 years of formal education (GFI), with a standard deviation of 2.62, for ease of understanding., Conclusion: Our research indicates that a significant proportion of websites related to TMD can be defined as a level of complexity that exceeds the ability to read comprehension of the general population., (© 2024 The Author(s). Journal of Oral Rehabilitation published by John Wiley & Sons Ltd.)
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- 2024
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22. Effectiveness of ultrasonography in the diagnosis of temporomandibular joint disorders: A systematic review and meta-analysis.
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Zaman MU, Alam MK, Alqhtani NR, Alqahtani M, Alsaadi MJ, Ronsivalle V, Cicciù M, and Minervini G
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Background: Temporomandibular disorders (TMDs) pose diagnostic challenges, and selecting appropriate imaging modalities is crucial for accurate assessment. This study aimed to compare the diagnostic accuracy and efficacy of ultrasonography (US) and magnetic resonance imaging (MRI) in identifying TMDs., Methods: A comprehensive meta-analysis was conducted, including studies that compared US and MRI for TMJ disorder assessments. Fixed-effects models were utilized to calculate pooled odds ratios (ORs) and relative risks (RRs) with 95% confidence intervals (CIs). Heterogeneity was assessed using the chi-squared test and I
2 statistic. Newcastle-Ottawa scale was used to assess the methodological quality of the studies included., Results: Six studies were included, involving a total of 281 participants. The meta-analysis demonstrated that MRI was statistically somewhat better than US in identifying TMJ disorders. The summary OR was 0.64 (95% CI: 0.46-0.90), and the summary RR was 0.80 (95% CI: 0.68-0.95). Heterogeneity among the studies was low (χ2 = 2.73, df = 5, p = .74; I2 = 0%). Demographic variables revealed variations in sample size, gender ratio and mean age across the studies., Conclusion: This meta-analysis provides evidence that MRI may be more effective than US in diagnosing TMDs. However, the study is limited by the small number of included studies and variations in demographic variables and study designs. Future research with larger samples and standardised protocols is essential to confirm and strengthen these findings. Understanding the diagnostic accuracy of MRI and US for TMJ disorders will aid clinicians in making informed decisions for effective TMJ disorder assessments and patient management., (© 2024 The Author(s). Journal of Oral Rehabilitation published by John Wiley & Sons Ltd.)- Published
- 2024
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23. Evaluation of lavender and rose aromatherapies on the success of inferior alveolar nerve block in symptomatic irreversible pulpitis: A randomized clinical trial.
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Mittal P, Jadhav GR, Kader M MA, Gaikwad AR, Shinde S, Di Blasio M, Ronsivalle V, Cicciù M, and Minervini G
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Trial Design: This is a prospective, block-randomized, blinded, multiple arm and parallel-group superiority clinical trial., Methods: Seventy-eight patients satisfying the recruitment standards, were randomly allocated into three groups as follows: Group I (n = 26) - Inferior alveolar nerve block (IANB) devoid of aromatherapy (AT); Group II (n = 26) - IANB with lavender AT and Group III - IANB with rose AT (n = 26) with the help of the ultrasonic aroma diffuser (with respective oils)for 20 min/2 h in operatories 1,2 and 3 respectively. For AT, 3-4 drops of lavender and rose-conditioned oils were added from a 100 ml solution containing 100 mg of these medicinal plants. The pre-operative (PRO) and access opening (AO) pain as well as the anxiety of patients were recorded using the Visual Analog Scale (VAS) and Modified Dental Anxiety Scale (MDAS) respectively. Data thus obtained was entered into the Excel sheet and subjected to statistical tests (analysis of variance and paired t -test). The p-value less than 0.05 was considered statistically significant., Results: Group I showed non-significant disparity between PRO and AO for both VAS as well as MDAS (p = 0.62, p = 0.71). However, group II (p = 0.04, p = 0.02) and group III (p = 0.03, p = 0.01) revealed significant differences between PO - AO VAS and MDAS. MDAS and VAS intergroup comparison revealed a significant difference among groups I and II (p = 0.03, p = 0.04), and groups I and III (p = 0.02, p = 0.03). However non-significant disparity was observed among groups II and III (p = 0.85, 0.34). Moreover, there was a statistically significant reduction in anxiety levels in females compared to males after rose AT (p = 0.02). Nevertheless, groups I and II did not show any gender predilection for anxiety as well as pain., Conclusion: Alleviation of dental anxiety as well as reduction in pain during AO of teeth with SIP can be achieved using Lavender and rose AT. In female patients, rose AT can be preferred over lavender AT., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors. Published by Elsevier Ltd.)
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- 2024
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24. Sensitivity of different part-mouth recording methods using a modified tooth wear index.
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Jain M, Jain V, Srivastava R, Jain S, Aggarwal A, Ronsivalle V, Cicciù M, and Minervini G
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Background: High prevalence of tooth wear (TW) worldwide makes it important to assess its level in different populations. In developing countries, a shift towards geriatric population makes the evaluation of this condition even more relevant. Most indices for tooth wear are full mouth indices, which make mass population screening challenging. The objective of this study was to establish whether part-mouth recordings using selective teeth can provide similar sensitivity of the modified tooth wear index., Methods: This cross-sectional study was carried out over 40 working days on 400 dentate individuals aged 14-70 years, having at least 16 scorable teeth. Firstly, full mouth tooth wear of study population was recorded and categorized into four groups based on severity and extent of tooth wear. Following this, group wise data extraction was done using the full mouth scores and six different types of part-mouth analyses was done to arrive at the system which provides the best sensitivity. These part-mouth recordings should be specific such that it can differentiate to the same groups of tooth wear in the reduced data as well. Data were analyzed by means of SPSS version 21.0 (P<0.05)., Results: In 83%, at least one tooth had the exposed dentine. Part-mouth recording using "12 anterior teeth" as index teeth showed a high level of sensitivity (87.8%) than others for measuring tooth wear data., Conclusions: The prevalence of tooth wear is high and "the part-mouth recording applied to the 12 anterior teeth" is a faster and reliable method in large population surveys for measuring tooth wear.
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- 2024
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25. The knowledge, attitude and perceived confidence in handling medical emergencies among dental students.
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Shenoy K M, Alkhelaiwi TM, Alasiri AH, Hejazi BR, Alkathiri KR, Ansari SH, Russo D, Ronsivalle V, Cicciù M, and Minervini G
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Background: According to Centers for Medicare and Medicaid Services HHS 2017, when a medical disease suddenly manifests itself with acute symptoms of sufficient intensity (including extreme pain) endangering the patient's health, seriously impairing body functions or bringing an organ or its portion to be seriously dysfunctional, a medical emergency has occurred. Therefore, this study aimed to assess the knowledge, attitude, and perceived confidence in handling medical emergencies among dental students by the means of conducting this investigation., Methods: This is a cross-sectional study conducted among the different hierarchies of dentists of Riyadh using an online survey; 387 dentists from varying clinical levels (9 to 12) were included in this study. The questionnaire used for this study consisted of questions related to demographic data followed by questions including knowledge, attitude, and confidence towards handling medical emergencies in clinics., Results: In this study, male participants represented 64.4% and female subjects represented 35.6% of the total population. Most of the undergraduates were in their 5
th year of dentistry school and accounted for 36.9%, followed by 6th year 36.2% and 4th year 26.8%. 67.1% of the undergraduates never encountered any medical emergency during their study, while 32.9% encountered an emergency. Furthermore, 58.4% of the analyzed subjects recorded medical history thoroughly, while priority in an emergency was adrenaline, with a percentage of 45%. For the patient suffering syncope the Trendelenburg position was chosen. Also, the first action choice with unresponsive patients was CPR., Conclusions: In the present study, the findings revealed that the majority of the population never encountered an emergency in their career, but their knowledge about drug priority and patient's position was good. Most of them do not measure vital signs routinely; specifically, females do not usually measure, while males measure when needed. About Basic Life Support (BLS), participants took BLS or were interested in taking it in the future; furthermore, in group population, both have taken it and are interested in further carrying it.- Published
- 2024
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26. Evaluation of the microleakage of new bioactive restorative materials: a comparative in-vitro study.
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Abdulsahib Najim B, Ghalib Abdulkhaliq A, Nahidh M, Ronsivalle V, Cicciù M, and Minervini G
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Background: This in-vitro study aimes to compare the microleakage of different restorative materials namely EQUIA Forte (GC, Japan), Tetric Evoceram (Ivoclar Vivadent, Liechtenstein), and Activa BioACTIVE., Methods: A standardized class V cavity has been created on the buccal surface of 40 sound premolar teeth. The cavity had the following measurements: 3 mm buccolingual height, 2 mm axial depth, and 4 mm mesiodistal width. The gingival margin was 1mm below the cementoenamel junction, whereas the coronal margin was on the enamel with cavosurface margins were butt joints all around. Four groups of teeth were restored according to the restorative materials. Under a stereomicroscope, the dye penetration test was used to measure the microleakage after thermocycling of the teeth. Data were compared using Kruskal-Wallis H and Mann-Whitney U tests., Results: Occlusal and gingival margins did not show statistically significant differences among the four groups, but an intragroup analysis revealed a significant difference., Conclusions: The type of restorative material did not appear to have a substantial impact on microleakage, according to the findings of the current investigation.
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- 2024
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27. Development, characterization, and biocompatibility and corrosion analyses of a silver-decorated graphene oxide and chitosan surface coating for titanium dental implants: A preliminary report.
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Biju D, Arumugam P, Kannan S, Yadalam PK, Ronsivalle V, Cicciù M, and Minervini G
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- Corrosion, Anti-Bacterial Agents pharmacology, Microscopy, Electron, Scanning, Humans, Graphite, Chitosan pharmacology, Chitosan chemistry, Titanium, Dental Implants, Silver pharmacology, Coated Materials, Biocompatible, Surface Properties, Materials Testing
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Background: Dental implants are increasingly favored as a therapeutic replacement option for edentulism. Titanium (Ti), due to its excellent biocompatibility and unique osseointegration properties, is commonly used in dental implants. Various surface modifications have been explored to improve osseointegration outcomes. Graphene oxide (GO) is a promising material with various applications. Chitosan, found in the exoskeleton of crustaceans and in marine algae, has several biomedical applications. Silver (Ag) is another promising antibacterial agent that increases permeability and damages the bacterial cell membrane upon binding., Objectives: The present study applied a novel implant surface coating of Ag-decorated GO and chitosan on Ti implants to promote bone formation. We further analyzed the physiochemical and antibacterial properties of this surface coating., Material and Methods: A solution was prepared by mixing 3 mL of 1% chitosan solution with 10 mg of Ag-GO nanoparticles (NPs). Titanium metal was heated to 70-80°C on a hotplate and the solution was applied onto Ti to obtain an adhesive surface coating. The coated implant was further analyzed for surface properties, using scanning electron microscopy (SEM), the energy dispersive X-ray (EDX) analysis, the attenuated total reflectance-Fourier transform infrared (ATR-FTIR) technique, and the biocompatibility and corrosion analyses., Results: The SEM analysis revealed a homogenously spread, rough, fibrillar and porous layer of coating on the metal surface. The EDX and ATR-FTIR analyses confirmed the successful coating of the implant surface with Ag-decorated GO and chitosan layers. The cell culture assay demonstrated excellent biocompatibility of the surface coating. The corrosion analysis showed improved corrosion resistance of the developed implant surface coating., Conclusions: The various analyses of the coating showed ideal properties for improved cell attachment, differentiation and proliferation while maintaining an antimicrobial environment on the implant surface.
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- 2024
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28. Evaluation of treatment outcomes with passive presurgical infant orthopaedics in patients with non-syndromic cleft lip and or palate: A systematic review conducted according to PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions.
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Bhatia N, Subramanian AK, Ramasamy N, Di Blasio M, Ronsivalle V, Cicciù M, and Minervini G
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Aim: The primary goal of the present comprehensive systematic review is to assess the treatment results attained through PSIO in individuals with NSCLP, as well as to explore its effectiveness. This will be accomplished by examining a range of existing published studies that focus on patient groups who have undergone PPIO., Materials: A comprehensive search strategy was devised by a single author for each database without language restrictions. The databases searched were PubMed, Cochrane library Google Scholar, Web of Science and Scopus. The search period was limited to the years 2001 to 2023. Duration and study design filter was used. Furthermore, conference proceedings, abstracts, and reference lists of relevant studies were sought to obtain additional records., Conclusion: The examined protocols for passive presurgical infant orthopaedics (PPIO) in individuals with CLP typically did not reveal notable treatment outcomes when compared to a lack of treatment across a range of domains. These domains encompass feeding patterns, facial aesthetics, maxillary dentoalveolar factors, cephalometric measurements, speech and language-related aspects, dental arch alignments, economic assessments, as well as occurrences of adverse effects or complications associated with applied appliances or procedures.
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- 2024
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29. Radiographic and diagnostic approaches for mandibular asymmetries in orthodontic practice: a narrative review.
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La Rosa S, Leonardi R, Ronsivalle V, Cicciù M, and Lo Giudice A
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- Humans, Radiography, Panoramic, Child, Imaging, Three-Dimensional methods, Orthodontics, Mandible diagnostic imaging, Facial Asymmetry diagnostic imaging, Facial Asymmetry diagnosis, Cone-Beam Computed Tomography methods
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Mandibular asymmetry refers to dimensional differences between the left and right sides of the mandible in terms of size, form and volume. This condition may result in problems with functionality as well as appearance. Early intervention is often deemed optimal for addressing mandibular asymmetry; however, there is a lack of consensus regarding the diagnostic approach and strategy for identifying asymmetries in developing individuals. The purpose of this narrative review (NR) is to provide a clinician-focused update on the radiographic techniques for identifying mandibular asymmetries in orthodontic patients. Selective database searches were conducted until November 2023 to assess the available literature on mandibular asymmetry diagnosis. A health-sciences librarian developed a search strategy utilizing appropriate terms associated with mandibular asymmetry diagnosis. The databases used were Web of Science, Embase, Scopus, Liliacs and PubMed. Fifty-two studies were included in this review and data regarding the evaluation of mandibular asymmetries were presented with a narrative approach delineating clinical indications based on retrieved findings. There is no unanimous consensus on the method for diagnosing mandibular asymmetries. Cone beam computed tomography emerges as the preferred examination method for diagnosing mandibular asymmetry, thanks to the assessment of a 3D structure with a 3D image. However, the use of only orthopantomography could be advisable as a first-line diagnostic tool in children due to less radiation exposure., Competing Interests: The authors declare no conflict of interest. Antonino Lo Giudice is serving as one of the Editorial Board members of this journal. We declare that Antonino Lo Giudice had no involvement in the peer review of this article and has no access to information regarding its peer review. Full responsibility for the editorial process for this article was delegated to NM., (©2024 The Author(s). Published by MRE Press.)
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- 2024
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30. Prevalence of obstructive sleep apnoea syndrome in oncological patients: A systematic review and meta-analysis.
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Kader MA, Sainudeen S, Khan AAG, Arora S, Ronsivalle V, Marrapodi MM, Cicciù M, and Minervini G
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- Humans, Prevalence, Risk Factors, Sleep Apnea, Obstructive epidemiology, Sleep Apnea, Obstructive complications, Neoplasms epidemiology, Neoplasms complications
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Background: Obstructive sleep apnoea syndrome (OSAS) has garnered increasing attention in recent years due to its potential association with cancer. This systematic review and meta-analysis aimed to assess the prevalence of OSAS in cancer patients through a comprehensive analysis of existing literature., Methods: This systematic review and meta-analysis, conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol, aimed to evaluate the prevalence of OSAS in cancer patients. A comprehensive search of electronic databases was performed to identify relevant studies published up to September 2021. Eligible studies reporting on the prevalence of OSAS in cancer patients, encompassing various study designs, were included in the analysis. Pooled estimates of the odds ratios (OR) with 95% confidence intervals (CIs) were calculated using a random effects model. Heterogeneity among the studies was assessed using the I
2 statistic., Results: Seventeen studies fulfilled the inclusion criteria and were subsequently included in the review. The prevalence of OSAS in cancer patients was estimated to have an overall OR of 0.80 (95% CI: 0.75-0.85). In comparison with non-cancer patients, cancer patients had a statistically significant greater risk of OSAS, as indicated by the total estimated RR for the prevalence of OSAS in cancer patients, which was 0.89 (95% CI: 0.86-0.92). Nonetheless, there was a significant amount of heterogeneity (I2 = 96%) among the studies., Conclusion: The overall data analysed in this review indicates that patients with cancer had far reduced likelihood of developing OSAS than individuals without cancer. However, the significant variation across the included studies highlights the need for additional investigation to fully clarify the complex association between OSAS and cancer incidence. These results emphasise how critical it is to identify OSAS as a possible comorbidity in cancer patients, one that should be taken into account for clinical management and ongoing research., (© 2024 John Wiley & Sons Ltd.)- Published
- 2024
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31. The Implications of Artificial Intelligence in Pedodontics: A Scoping Review of Evidence-Based Literature.
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La Rosa S, Quinzi V, Palazzo G, Ronsivalle V, and Lo Giudice A
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Background: Artificial intelligence (AI) has emerged as a revolutionary technology with several applications across different dental fields, including pedodontics. This systematic review has the objective to catalog and explore the various uses of artificial intelligence in pediatric dentistry., Methods: A thorough exploration of scientific databases was carried out to identify studies addressing the usage of AI in pediatric dentistry until December 2023 in the Embase, Scopus, PubMed, and Web of Science databases by two researchers, S.L.R. and A.L.G., Results: From a pool of 1301 articles, only 64 met the predefined criteria and were considered for inclusion in this review. From the data retrieved, it was possible to provide a narrative discussion of the potential implications of AI in the specialized area of pediatric dentistry. The use of AI algorithms and machine learning techniques has shown promising results in several applications of daily dental pediatric practice, including the following: (1) assisting the diagnostic and recognizing processes of early signs of dental pathologies, (2) enhancing orthodontic diagnosis by automating cephalometric tracing and estimating growth and development, (3) assisting and educating children to develop appropriate behavior for dental hygiene., Conclusion: AI holds significant potential in transforming clinical practice, improving patient outcomes, and elevating the standards of care in pediatric patients. Future directions may involve developing cloud-based platforms for data integration and sharing, leveraging large datasets for improved predictive results, and expanding AI applications for the pediatric population.
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- 2024
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32. Gingival health, plaque accumulation, and restoration outcomes in deciduous anterior teeth: evaluating zirconia crowns versus composite resin strip crowns.
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Vaddamanu SK, Veerabasavaiah BT, Alshadidi AA, Alhamoudi FH, Saini RS, Ronsivalle V, Cicciù M, and Minervini G
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Background: Zirconia crowns, resembling crystals and with enamel-like aesthetics, are recent entrants in pediatric restorative dentistry. Despite growing use, their empirical efficacy remains under-explored. The aim of this study is to compare resin composite strip crowns and premanufactured zirconia crowns on primary maxillary incisors., Methods: In the Pediatric Dental Clinics, 240 primary maxillary incisors (69 patients) were treated with either zirconia (120 teeth) or composite strip crowns (120 teeth). Evaluations of gingival health, plaque, secondary caries, restoration failure, and opposing teeth wear occurred at 3, 6, and 12-month intervals., Results: At 3 months, zirconia crowns showed less gum bleeding (P=0.006) and plaque. Through 6 and 12 months, zirconia crowns exhibited fewer failures but higher opposing teeth wear. Strip crowns indicated greater tooth material loss., Conclusions: Zirconia crowns demonstrated superior gingival health and durability over composite resin strip crowns but caused increased wear on opposing teeth.
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- 2024
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33. Comparative analysis of treatment outcomes between Bi-Maxillary Plates and Facemask for treating class III malocclusion in growing subjects. A retrospective study.
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Ronsivalle V, Quinzi V, Marzo G, Minervini G, Leonardi R, and Lo Giudice A
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- Humans, Retrospective Studies, Female, Child, Male, Treatment Outcome, Bone Plates, Follow-Up Studies, Mandible, Adolescent, Alveolar Process, Malocclusion, Angle Class III therapy, Extraoral Traction Appliances, Cephalometry, Maxilla, Orthodontic Appliance Design
- Abstract
Aim: To comparatively analyse the skeletal and dento-alveolar changes after treatment with Class III Bi-Maxillary Plates (BMPs) and FM appliances in growing patients with Class III skeletal malocclusion., Conclusion: BMPs with class III elastics provided a similar pattern of skeletal and dento-alveolar changes compared to FMs, however supported by slightly greater dentoalveolar effects that contribute to the correction of the class III malocclusion in growing subjects.
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- 2024
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34. Prediction of Interactomic HUB Genes in Periodontitis With Acute Myocardial Infarction.
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Thilagar SS, Yadalam PK, Ronsivalle V, Cicciù M, and Minervini G
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- Humans, Biomarkers metabolism, Gene Expression Profiling, Bayes Theorem, Transcriptome genetics, Myocardial Infarction genetics, Myocardial Infarction metabolism, Periodontitis genetics, Periodontitis metabolism, Machine Learning
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Background: Acute myocardial infarction (AMI) risk correlates with C-reactive protein (CRP) levels, suggesting systemic inflammation is present well before AMI. Studying different types of periodontal disease (PD), extremely common in individuals at risk for AMI, has been one important research topic. According to recent research, AMI and PD interact via the systemic production of certain proinflammatory and anti-inflammatory cytokines, small signal molecules, and enzymes that control the onset and development of both disorders' chronic inflammatory reactions. This study uses machine learning to identify the interactome hub biomarker genes in acute myocardial infarction and periodontitis., Methods: GSE208194 and GSE222883 were chosen for our research after a thorough search using keywords related to the study's goal from the gene expression omnibus (GEO) datasets. DEGs were identified from the GEOR tool, and the hub gene was identified using Cytoscape-cytohubba. Using expression values, Random Forest, Adaptive Boosting, and Naive Bayes, widgets-generated transcriptomics data, were labelled, and divided into 80/20 training and testing data with cross-validation. ROC curve, confusion matrix, and AUC were determined. In addition, Functional Enrichment Analysis of Differentially Expressed Gene analysis was performed., Results: Random Forest, AdaBoost, and Naive Bayes models with 99%, 100%, and 75% AUC, respectively. Compared to RF, AdaBoost, and NB classification models, AdaBoost had the highest AUC. Categorization algorithms may be better predictors than important biomarkers., Conclusions: Machine learning model predicts hub and non-hub genes from genomic datasets with periodontitis and acute myocardial infarction., Competing Interests: The authors report no conflicts of interest., (Copyright © 2024 by Mutaz B. Habal, MD.)
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- 2024
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35. The Effects of a Cool Saline Solution Irrigation on Mandibular Third Molar Extraction Site: A Postoperative Split-Mouth Evaluation.
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Ronsivalle V, Cicciù M, and Fiorillo L
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- Humans, Adult, Male, Female, Mandible surgery, Postoperative Complications prevention & control, Edema prevention & control, Edema etiology, Pain Measurement, Molar, Third surgery, Tooth Extraction, Saline Solution administration & dosage, Therapeutic Irrigation methods, Pain, Postoperative prevention & control, Tooth, Impacted surgery
- Abstract
Objective: This study aimed to evaluate the effects of sterile saline solution irrigation (lavage) performed after mandibular third molar extraction on postoperative complications, utilizing a split-mouth randomized clinical trial design., Methods: Seventeen healthy participants requiring bilateral mandibular third molar extraction were enrolled in this single-center study. In each participant, one impacted third molar was designated as the experimental group and subjected to saline lavage at 4 °C. In contrast, the control group was the other impacted third molar, undergoing saline lavage at 25 °C. Various parameters, including postoperative pain, mouth opening, and facial swelling, were assessed using standardized measures and three-dimensional facial scanning at multiple time points., Results: The average age of participants was 26.66 ± 4.1 years, with no postoperative complications observed in either group. The duration of surgery did not significantly differ between groups. Postoperative pain was significantly reduced in the experimental group during the immediate postoperative period compared with the control group, but this difference diminished over time. No significant differences were observed in mouth opening or facial swelling between groups at any time., Conclusion: In site 4 °C, sterile saline solution irrigation after mandibular third molar extraction may effectively reduce early postoperative complications, particularly pain, without prolonging surgical duration., Competing Interests: The authors report no conflicts of interest., (Copyright © 2024 by Mutaz B. Habal, MD.)
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- 2024
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36. Digital denture with mucostatic base and functional borders: A cast-free digital technique.
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Lo Russo L, Guida L, Ronsivalle V, and Ercoli C
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Digital complete dentures fabricated using a mucostatic impression, like intraoral scans, are desirable for their beneficial effect on long-term residual ridge stability but may have less retention than those fabricated with a mucocompressive impression. Border molding procedure may improve initial retention, thus favoring adaptation to new dentures, especially in cases where neuromuscular dysfunctions may diminish the patient's ability to cope with adapting to existing motor patterns or learn new ones. However, a mucocompressive impression may cause higher residual ridge resorption, thus resulting in a retention decrease over time. A desirable combination would be a digital denture with a mucostatic intaglio surface obtained from intraoral scans and functional borders. A cast-free digital workflow for that is demonstrated in this technical report., (© 2024 by the American College of Prosthodontists.)
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- 2024
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37. Medium-term effects of rapid maxillary expansion on nasal cavity and pharyngeal airway volumes considering age as a factor: A retrospective study.
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Ronsivalle V, Leonardi R, Lagravere M, Flores-Mir C, Grippaudo C, Alessandri Bonetti G, and Lo Giudice A
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- Humans, Retrospective Studies, Child, Male, Female, Adolescent, Age Factors, Nasopharynx diagnostic imaging, Nasopharynx anatomy & histology, Maxilla diagnostic imaging, Palatal Expansion Technique, Nasal Cavity diagnostic imaging, Nasal Cavity anatomy & histology, Pharynx diagnostic imaging, Pharynx anatomy & histology, Cone-Beam Computed Tomography
- Abstract
Objectives: The medium-term effects of rapid maxillary expansion (RME) on nasal cavity (NC) and upper airway (UA) dimensions based on chronological age are still unclear. This retrospective study evaluated the medium-term changes occurring in the NC and pharyngeal airways (PA) after RME in two distinct age-based cohorts of patients., Methods: This retrospective study included 48 subjects who underwent RME grouped in two cohorts: a 6-9-year-old group (EEG group: early expansion group - 25 subjects) and an 11-14-year-old group (LEG group: late expansion group - 23 subjects). NC and PA volumes were analyzed from CBCT imaging segmentation before RME (T0) and twelve months after RME (T1). The amount of maxillary expansion (PW) and minimal cross-sectional area (CSmin) were also considered., Results: All PAs' volumetric sub-regions, CSmin and PW showed a significant volumetric increment (p < 0.05). Inter-group comparisons showed significant differences (p < 0.05) for nasopharynx and CSmin parameters (p < 0.05), while no significant changes were recorded for the other UA's sub-regions and PW (p > 0.05). According to a deviation analysis, part of the UA increase (more marked for the nasopharynx area) may have occurred due to reduced adenotonsillar tissues, which were larger in the EEG group., Conclusions: Twelve months after treatment, clinicians should not expect changes in the UAs dimensions to be solely related to treatment effects of RME; instead, normal craniofacial growth changes and spontaneous regression of the adenotonsillar tissue could represent the most significant factors influencing UAs changes., Clinical Significance: From the clinical perspective, the results of the present study encourage caution when considering the therapeutic effects of RME on airways dimensions., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier Ltd.)
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- 2024
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38. Indications for Dental Specialists for Treating Obstructive Sleep Apnea with Mandibular Advancement Devices: A Narrative Review.
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Lo Giudice A, La Rosa S, Ronsivalle V, Isola G, Cicciù M, Alessandri-Bonetti G, and Leonardi R
- Abstract
Obstructive sleep apnea (OSA) syndrome is characterized by repeated airway collapse during sleep. It determines cardiovascular, pulmonary, and neurocognitive consequences and is associated with several daytime and nighttime symptoms that influence the patient's quality of life. The contribution of the dental specialist in the clinical management of OSA patients entails participating in the screening process as diagnostic sentinels and providing adequate treatment using mandibular advancement devices (MADs). Since the treatment of OSA requires a multidisciplinary approach, including different medical specialists, dentists should have a comprehensive understanding of medical and dental factors that influence the strategy and effectiveness of OSA treatment with MAD. Such expertise is crucial in determining the appropriate treatment indications and helps clinicians establish a consolidated position within the multidisciplinary OSA team. In this regard, this review summarizes the evidence of the clinical indications for MAD treatment and provides the dental specialist with helpful information about medical, functional, and other relevant factors that should be considered during diagnosis, treatment plan, and follow-up stages. Information retrieved was organized and discussed, generating specific domains/queries oriented to the clinical management of OSA patients from the clinical perspective of dental specialists., Competing Interests: The authors declare that there are no conflicts of interest regarding the publication of this paper., (Copyright © 2024 Antonino Lo Giudice et al.)
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- 2024
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39. Prediction of interactomic hub genes in PBMC cells in type 2 diabetes mellitus, dyslipidemia, and periodontitis.
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Yadalam PK, Arumuganainar D, Ronsivalle V, Di Blasio M, Badnjevic A, Marrapodi MM, Cervino G, and Minervini G
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- Humans, Leukocytes, Mononuclear, Algorithms, Computational Biology, Gene Expression Profiling, Diabetes Mellitus, Type 2, Chronic Periodontitis, Dyslipidemias
- Abstract
Background and Objective: In recent years, the complex interplay between systemic health and oral well-being has emerged as a focal point for researchers and healthcare practitioners. Among the several important connections, the convergence of Type 2 Diabetes Mellitus (T2DM), dyslipidemia, chronic periodontitis, and peripheral blood mononuclear cells (PBMCs) is a remarkable example. These components collectively contribute to a network of interactions that extends beyond their domains, underscoring the intricate nature of human health. In the current study, bioinformatics analysis was utilized to predict the interactomic hub genes involved in type 2 diabetes mellitus (T2DM), dyslipidemia, and periodontitis and their relationships to peripheral blood mononuclear cells (PBMC) by machine learning algorithms., Materials and Methods: Gene Expression Omnibus datasets were utilized to identify the genes linked to type 2 diabetes mellitus(T2DM), dyslipidemia, and Periodontitis (GSE156993).Gene Ontology (G.O.) Enrichr, Genemania, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were used for analysis for identification and functionalities of hub genes. The expression of hub D.E.G.s was confirmed, and an orange machine learning tool was used to predict the hub genes., Result: The decision tree, AdaBoost, and Random Forest had an A.U.C. of 0.982, 1.000, and 0.991 in the R.O.C. curve. The AdaBoost model showed an accuracy of (1.000). The findings imply that the AdaBoost model showed a good predictive value and may support the clinical evaluation and assist in accurately detecting periodontitis associated with T2DM and dyslipidemia. Moreover, the genes with p-value < 0.05 and A.U.C.>0.90, which showed excellent predictive value, were thus considered hub genes., Conclusion: The hub genes and the D.E.G.s identified in the present study contribute immensely to the fundamentals of the molecular mechanisms occurring in the PBMC associated with the progression of periodontitis in the presence of T2DM and dyslipidemia. They may be considered potential biomarkers and offer novel therapeutic strategies for chronic inflammatory diseases., (© 2024. The Author(s).)
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- 2024
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40. Evaluation and assessment of the survival of tooth implant supported prosthesis in tooth and implant supported rehabilitation cases with metal frameworks.
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Narde J, Ahmed N, Marrapodi MM, Siurkel Y, Ronsivalle V, Cicciù M, and Minervini G
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- Humans, Male, Female, Follow-Up Studies, Dental Implantation, Endosseous methods, Dental Implantation, Dental Prosthesis, Implant-Supported, Dental Restoration Failure, Treatment Outcome, Dental Prosthesis Design, Dental Implants adverse effects, Immediate Dental Implant Loading, Alveolar Bone Loss etiology
- Abstract
Introduction: Over the years, implant therapy has been a commonly used treatment option for individuals who are partially or totally edentulous, with a long-term success rate of over 90%. With significant advancements in biomaterials and technology, implant dentistry can now conduct prosthetic rehabilitations in the majority of patients catering to all types of needs. However, in order to meet the demands of a patient base that is always growing, new trends in implantology are emerging in recent years that are focused on minimally invasive surgery and financial sustainability. In certain clinical scenarios, connecting teeth and implants to support fixed partial prosthesis (FPPs) may be a predictable and workable course of treatment., Materials and Methods: 22 patients were selected for this study who had tooth and implant supported prosthesis placed as a final restoration. Out of these 22 patients; 12 were male and 10 were female patients. Implants were placed following proper protocol and if grafting procedures were required they were carried out. A second stage surgical procedure was carried out and delayed loading protocols were followed. The statistical analysis was done using the IBM SPSS 24.0, Chicago, USA. The survival of the implants and teeth were measured by the Kaplan Meier survival scale. Bone loss was assessed at baseline(upon loading), 12 months and 24 months., Results: The implant survival rate was measured at 6 months, 12 months, 18 months and 24 months. At 24 months, one implant showed failure, so the survival rate of the implants were 95.4%. Bone loss of 1 mm was seen around one implant at 12 months. Bone loss of 1 and 2 mm was present around two implants and one implant respectively at 24 months., Conclusion: From the results of this study, we can conclude that tooth implant supported prosthesis show very good survival when used in rehabilitation cases., (© 2024. The Author(s).)
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- 2024
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41. Accuracy of temporomandibular disorders diagnosis evaluated through the diagnostic criteria for temporomandibular disorder (DC/TDM) Axis II compared to the Axis I evaluations: a systematic review and meta-analysis.
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Minervini G, Marrapodi MM, Siurkel Y, Cicciù M, and Ronsivalle V
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- Humans, Quality of Life, Temporomandibular Joint, Mandible, Facial Pain etiology, Temporomandibular Joint Disorders psychology
- Abstract
Background: The temporomandibular joint (TMJ) is a complex joint that facilitates mandibular movements during speech, chewing, and swallowing activities. The Axis I evaluation of the DC/TMD focuses on assessing physical diagnoses related to TMDs. It includes an assessment of pain and functional limitations, such as jaw opening range, joint sounds, and joint tenderness. The Axis II evaluation of the DC/TMD provides information on the patient's psychological status and quality of life. This Systematic Review with Meta-Analysis aimed to evaluate the accuracy of Temporomandibular Disorders diagnosis considered through the Diagnostic Criteria for Temporomandibular Disorder (DC/TDM) axis II compared to the Axis I evaluations., Methods: A search was made in PubMed, Web of Science and Lilacs for articles published from the inception until 20 January 2023. We applied the Population, Exposure, Comparator, and Outcomes (PECO) model [1] to assess document eligibility. Only studies that evaluated patients by DC/TMD Axis I and Axis II were considered. Review Manager version 5.2.8 (Cochrane Collaboration) was used for the pooled analysis. We measured the odds ratio (OR) between the two groups (Axis I and Axis II)., Results: Fifty-one articles were selected because of the search. Four papers were excluded before the screening: 2 pieces were not in English, and two were reviewed. The remaining 47 articles were selected for the title and abstract screening to evaluate whether they met the PECO criteria. Among these, four papers were established; the overall effect showed that there was no difference in TMD diagnosis between Axis I and Axis II (RR 1.17; 95% CI: 0.80- 1.71; Z:0.82; P = .41), suggesting that there is no difference between Axis I and Axis II., Conclusion: In conclusion, DC/TMD is an effective tool for the diagnosis of TMD. It improves the accuracy of TMD diagnosis, allows for the classification of subtypes, and assesses psychosocial factors that may impact the development or maintenance of TMD symptoms., (© 2024. The Author(s).)
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- 2024
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42. Prevalence of temporomandibular disorders in clear aligner patients using orthodontic intermaxillary elastics assessed with diagnostic criteria for temporomandibular disorders (DC/TMD) axis II evaluation: A cross-sectional study.
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Uzunçıbuk H, Marrapodi MM, Meto A, Ronsivalle V, Cicciù M, and Minervini G
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- Humans, Cross-Sectional Studies, Facial Pain etiology, Prevalence, Temporomandibular Joint Disorders diagnosis, Temporomandibular Joint Disorders epidemiology, Temporomandibular Joint Disorders etiology, Orthodontic Appliances, Removable adverse effects
- Abstract
Background: The objective of this investigation is to assess the relationship between the utilisation of orthodontic intermaxillary elastics and temporomandibular disorder (TMD) symptoms in clear aligner patients and to examine the correlation between the elastic usage time with the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD)-Axis II Evaluation Forms., Methods: This study was carried out on a total of 40 clear aligner patients using intermaxillary elastics in the experimental group and 30 clear aligner patients who did not use any intermaxillary elastics in the control group. The data were evaluated using the Mann-Whitney U, chi-square, Fisher's exact chi-square, and Fisher Freeman Halton exact chi-square tests., Results: The characteristic pain intensity, mastication, mobility, communication, global and PHQ-9 scores of the experimental group were significantly higher than those of the control group (p < .05). The characteristic pain intensity score, interference score and chronic pain grade score of patients using Class III elastics were statistically significantly higher than those of patients using Class II elastics (p < .05). Patients who used elastics for less than 6 months had statistically significantly higher PHQ-9 scores than those who used elastics for more than 6 months (p < .05)., Conclusions: Orthodontic treatment may affect occlusion, bite force and jaw movement, which may cause or worsen TMD symptoms, and the DC/TMD questionnaires can determine if orthodontic patients acquire TMD by assessing their psychosocial state and pain-related problems., (© 2023 The Authors. Journal of Oral Rehabilitation published by John Wiley & Sons Ltd.)
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- 2024
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43. Prevalence of temporomandibular disorders in juvenile idiopathic arthritis evaluated with diagnostic criteria for temporomandibular disorders: A systematic review with meta-analysis.
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Ronsivalle V, Marrapodi MM, Tirupathi S, Afnan L, Cicciù M, and Minervini G
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- Humans, Prevalence, Child, Adolescent, Temporomandibular Joint Disorders epidemiology, Temporomandibular Joint Disorders diagnosis, Arthritis, Juvenile complications, Arthritis, Juvenile epidemiology, Arthritis, Juvenile diagnosis
- Abstract
Background: Juvenile idiopathic arthritis (JIA) is a very common systemic inflammatory rheumatic disorder affecting the musculoskeletal system in children below 16 years of age. Joint inflammation and tissue destruction is the prime characteristic of the disease. Along with the systemic involvement in the long joints, several studies are mentioning the increased association of temporomandibular disorders (TMDs) in JIA. This current systematic review intends to find the prevalence rate of TMD in JIA-affected individuals as compared to healthy controls., Methods: We have searched in PubMed, Scopus and Ovid SP for articles published between the timeframe 1 January 1990 and 1 June 2023. All the searched articles were subjected to the Population, Exposure, Comparison, and Outcome model (PECO) based on which inclusion or exclusion is carried out. Participants (P) are children below 18 years of age, Exposure (E) is children or adolescents with a diagnosis of JIA, Comparator is age and gender-matched healthy controls who has no JIA or any systemic disorder, Outcome (O) is the prevalence of TMD. Only the studies that evaluated TMD using diagnostic criteria for evaluation of TMD (DC/TMD) were included in the analysis. We have set the exclusion to the following reasons- diagnostic sensitivity studies, case reports, and systematic reviews. The software Review Manager Version 5.4 (Cochrane Collaboration) was used to perform the pooled analysis. We measured the risk ratio (RR) between the two groups (JIA and no JIA) for the outcome TMD., Results: The pooled total included subjects were 366 in this review with an established diagnosis of JIA as evaluated by DC/TMD. The overall effect of the pooled data suggests that there is a significant difference in the TMD prevalence in the JIA group when compared to the control, results suggest that TMD is more prevalent in the JIA group RR 3.86; 95% CI [2.59, 5.76]., Conclusion: Overall, based on the data we can suggest a positive relationship between JIA and TMD, hence presence of JIA can be a risk factor for the development of TMD. The sensitivity of DC/TMD is low when compared to magnetic resonance imaging., (© 2023 The Authors. Journal of Oral Rehabilitation published by John Wiley & Sons Ltd.)
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- 2024
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44. Evaluation and assessment of the wettabilty and water contact angle of modified poly methyl methacrylate denture base materials against PEEK in cast partial denture framework: an in vitro study.
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Narde J, Ahmed N, Siurkel Y, Marrapodi MM, Ronsivalle V, Cicciù M, and Minervini G
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- Denture Bases, Denture, Partial, Ketones, Materials Testing, Methacrylates, Polyethylene Glycols, Water, Wettability, Acrylic Resins, Benzophenones, Polymers, Polymethyl Methacrylate
- Abstract
Introduction: The prevalence of adults with partially dental arches is expected to be more than imagined and patients requiring replacement of missing teeth are slowly increasing in number too. Removable partial dentures are known to provide for substantial replacement for the missing teeth with also added advantages when compared to fixed or implant prosthesis, mainly in elderly patients. Denture base material performance and durability are greatly influenced by wettability and water contact angle. In the case of dentures; adequate moisture distribution is necessary to ensure excellent wettability which has an influence on comfort and oral health. The purpose of conducting this study was to find out whether the advancements made using PEEK (Polyether ether ketone) would prove to be more beneficial than the current upgrades in the current material spectrum., Materials and Methods: This study was performed under in vitro conditions. All the fabrication and processing was done only by one operator. The materials used were divided into three groups each comprising 20 samples. Group A was modified polymethylmethacrylate (Bredent Polyan), Group B was polyoxymethylene acetal resin (Biodentaplast) and Group C was PEEK. An Ossila Goniometer was used to measure the contact angle. The three types of liquids used for the testing included distilled water, natural saliva and mouth wetting solution (Wet Mouth Liquid, ICPA India). Human saliva was collected from an individual with no medical conditions and normal salivary secretion., Results: The data was analyzed using One-way ANOVA test and a pairwise comparison using the Post Hoc Tukey's Honest Significant Difference. Table 1 consists of the mean water contact angles of the denture base materials and mean contact angles of various denture base materials. In saliva, mouth wetting solution and distilled water, the highest mean and least mean contact angle was seen in Polyan and Biodentaplast respectively. A signicant difference was seen between PEEK and Polyan and Biodentaplast and Polyan on further comparison., Conclusion: From the resources and the materials at our disposal, it could be concluded that Polyan, Biodentaplast and PEEK and could be used as viable options in cast partial denture framework., (© 2024. The Author(s).)
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- 2024
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45. Pregnancy related factors and temporomandibular disorders evaluated through the diagnostic criteria for temporomandibular disorders (DC/TMD) axis II: a cross sectional study.
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Minervini G, Marrapodi MM, La Verde M, Meto A, Siurkel Y, Ronsivalle V, and Cicciù M
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- Pregnancy, Humans, Female, Cross-Sectional Studies, Facial Pain diagnosis, Estrogens, Medically Unexplained Symptoms, Temporomandibular Joint Disorders diagnosis
- Abstract
Introduction: Temporomandibular disorder (TMD) is a multifaceted condition impacting the chewing system, with its frequency varying across different age groups and showing a higher incidence in women. The involvement of estrogen in TMD has been examined due to the presence of estrogen receptors in the TMJ area. However, the exact effect of estrogen on TMD is complex. During pregnancy, marked by significant hormonal fluctuations, the impact on TMD has been hypothesized but remains unclear due to inconsistent results from various studies., Methods: In this cross-sectional study, we enrolled 32 pregnant women consecutively. We gathered information on demographics, TMD evaluations (using the Graded Chronic Pain Scale, Jaw Functional Limitation Scale-20, and Oral Behaviors Checklist), and mental health assessments (including Patient Health Questionnaire-9, Patient Health Questionnaire-15, and Generalized Anxiety Disorder-7). We employed descriptive statistics to summarize continuous and categorical data and used t-tests and chi-square tests for comparisons. We also conducted multivariate linear regression, adjusted for demographic factors, to investigate correlations., Results: The study group mainly consisted of women aged 30-35 (40.6%) and 25-30 (18.8%). Most participants had completed high school (50%) and were married (71.9%). A notable association was found between younger women (under 30) and higher levels of somatic symptoms (p = 0.008) and generalized anxiety (p = 0.015). Women in their second trimester showed lower severity of somatic symptoms (p = 0.04). A significant link was also observed between depression severity and somatic symptom severity (p = 0.01). However, we found no significant correlations with other TMD-related health aspects., Discussion: Our study identified significant associations between psychosomatic and psychological symptoms with variables like age and pregnancy trimester in pregnant women. However, it notably failed to establish a clear relationship between pregnancy-related factors and the severity of temporomandibular disorders (TMD). More comprehensive studies with larger participant pools are necessary to further validate and expand these findings., (© 2024. The Author(s).)
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- 2024
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46. A scanning electron microscopy investigation of the precision of three orthodontic bracket slot systems.
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Nahidh M, Yassir YA, Marrapodi MM, Di Blasio M, Ronsivalle V, Cicciù M, and Minervini G
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- Humans, Microscopy, Electron, Scanning, Orthodontic Wires, Materials Testing, Stainless Steel, Torque, Dental Stress Analysis, Orthodontic Appliance Design, Orthodontic Brackets
- Abstract
Objective: One of the most imprortant factors in achieving ideal teeth positions is the precision of the slot dimensions of orthodontic brackets into the archwires are inserted.This study aimed to assess the accuracy of the dimensions of orthodontic bracket slots and molar buccal tube apertures and to compare them with the specifications provided by the manufacturers., Method: A total of sixty brackets and ten molar buccal tubes with varying slot heights were examined using a scanning electron microscope from the mesial side. The dimensions and morphology of these bracket slots and buccal tubes apertures were assessed using the AutoCAD Software. A one-sample t-test was conducted to compare the measurements with the values provided by the manufacturer., Results: The findings of the present study indicated that the height of the measured bracket slots and buccal tube apertures dimensions were significantly larger than the actual dimensions and exhibiting divergent walls. On the other hand, the depth of the brackets slots showed significantly smaller values than the actual one., Conclusion: A need for careful consideration when selecting a commercially accessible brand for everyday use is essential as certain materials may not meet acceptable standards., (© 2024. The Author(s).)
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- 2024
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47. Prenatal incidence of cleft lip/palate and cocaine abuse in parents: a systematic review and meta-analysis.
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Alayyash A, Alam MK, Rashid ME, Mathew A, Di Blasio M, Ronsivalle V, Cicciù M, and Minervini G
- Abstract
Background: The study aimed to investigate the association between maternal cocaine abuse during pregnancy and the prevalence of cleft lip/palate (CL/P) in offspring, synthesizing existing evidence through a systematic review and meta-analysis. CL/P is a congenital craniofacial anomaly with complex etiology, and prior research has suggested potential links between maternal cocaine use and CL/P. However, these associations remain inconclusive., Methods: A comprehensive literature search was conducted to identify relevant studies published up to the study's cutoff date in September 2021. Several databases were systematically searched using predefined search terms. Inclusion criteria were set to encompass studies reporting on the prevalence of CL/P in infants born to mothers with a history of cocaine use during pregnancy, with a comparison group of non-cocaine-using mothers. Data were extracted, and a meta-analysis was performed using a random-effects model to calculate pooled odds ratios (OR) and relative risks (RR) with their respective 95% confidence intervals (CI)., Results: The review included data from 4 studies that met the inclusion criteria. The combined OR from two studies was 0.05 (95% CI: 0.00, 4.41), which does not suggest a statistically significant association between prenatal cocaine exposure and the incidence of CL/P due to the confidence interval crossing the null value. Additionally, the combined RR was 0.17 (95% CI: 0.04, 0.66), indicating a statistically significant decrease in the risk of CL/P associated with prenatal cocaine exposure. These results, with an OR that is not statistically significant and an RR suggesting decreased risk, should be interpreted with caution due to considerable heterogeneity and variability among the included studies' findings. Further research is needed to clarify these associations., Conclusion: The findings from this systematic review and meta-analysis suggest that maternal cocaine use during pregnancy is not a statistically significant independent risk factor for the development of CL/P in offspring. These results underscore the multifactorial nature of CL/P etiology and emphasize the importance of considering other genetic, environmental, and nutritional factors in understanding the condition's origins. While the study provides important insights, limitations such as data heterogeneity and potential confounders should be acknowledged. Future research should adopt rigorous study designs and explore a broader range of potential risk factors to comprehensively elucidate CL/P development., (© 2024. The Author(s).)
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- 2024
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48. Prevalence of temporomandibular disorders diagnosis in patients treated with Herbst appliance: a systematic review and meta-analysis.
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Minervini G, Di Blasio M, Franco R, Marrapodi MM, Vaienti B, Cicciù M, and Ronsivalle V
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- Humans, Prevalence, Cephalometry, Orthodontic Appliances, Functional, Malocclusion, Angle Class II therapy, Temporomandibular Joint Disorders epidemiology, Temporomandibular Joint Disorders therapy
- Abstract
Background: The Herbst appliance is an excellent therapy for treating class II malocclusions with increased overjet. Its mechanics involve propelling the mandibular bone using two pistons the patient cannot remove. The so-called bite-jumping keeps the mandible in a more anterior position for a variable period, usually at least 6 months. This appliance does not inhibit joint functions and movements, although there are scientific papers in the literature investigating whether this appliance can lead to temporomandibular disorders. This systematic review aims to evaluate whether Herbst's device can cause temporomandibular diseases by assessing the presence of TMD in patients before and after treatment., Methods: A literature search up to 3 May 2023 was carried out on three online databases: PubMed, Scopus and Web of Science. Only studies that evaluated patients with Helkimo scores and Manual functional analysis were considered, as studies that assessed the difference in TMD before and after Herbst therapy. Review Manager version 5.2.8 (Cochrane Collaboration) was used for the pooled analysis. We measured the odds ratio (OR) between the two groups (pre and post-Herbst)., Results: The included papers in this review were 60. Fifty-seven were excluded. In addition, a manual search was performed. After the search phase, four articles were considered in the study, one of which was found through a manual search. The overall effect showed that there was no difference in TMD prevalence between pre-Herbst and post-Herbst therapy (OR 0.74; 95% CI: 0.33-1.68)., Conclusion: Herbst appliance seems not to lead to an increase in the incidence of TMD in treated patients; on the contrary, it appears to decrease it. Further studies are needed to assess the possible influence of Herbst on TMDs., (© 2024. The Author(s).)
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- 2024
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49. Prevalence of Bruxism in alcohol abusers: a systematic review conducted according to PRISMA guidelines and the cochrane handbook for systematic reviews of interventions.
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Ronsivalle V, Marrapodi MM, Siurkel Y, Cicciù M, and Minervini G
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- Humans, Cross-Sectional Studies, Prevalence, Risk Factors, Systematic Reviews as Topic, Alcoholism complications, Alcoholism epidemiology, Sleep Bruxism epidemiology, Sleep Bruxism etiology
- Abstract
Background: Bruxism, a common oral parafunctional behavior characterized by the grinding or clenching of teeth, is a multifactorial condition with potentially detrimental effects on oral health and overall well-being. In recent years, there has been growing interest in understanding the relationship between bruxism and alcohol abuse, as both are prevalent issues that may share underlying factors and exacerbate each other. This systematic review, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, aims to evaluate the frequency of bruxism among individuals with alcohol abuse., Methods: A comprehensive search of electronic databases, including PubMed, Lilacs, Scopus and Web of Science, will be conducted to identify relevant studies published up to the knowledge cutoff date in January 2023. The search strategy will include keywords related to bruxism, alcohol abuse, and their synonyms. Inclusion criteria will encompass original research studies, such as observational, cross-sectional, cohort, and case-control studies, as well as clinical trials, that examine the relationship between bruxism and alcohol abuse. Two independent reviewers will perform the study selection, data extraction, and quality assessment, with discrepancies resolved by consensus., Results: The systematic review will present a summary of the identified studies, including the study design, characteristics of the study populations, and key findings related to the association between bruxism and alcohol abuse. The potential mechanisms underlying this relationship will also be explored. Subgroup analyses and the quality of evidence will be assessed. Finally, the implications of this association for clinical practice and further research will be discussed., Conclusions: This systematic review will contribute to a better understanding of the interplay between bruxism and alcohol abuse, shedding light on potential risk factors, mechanisms, and clinical implications. The findings may have significant implications for the prevention, management, and treatment of bruxism, particularly in individuals with a history of alcohol abuse., (© 2024. The Author(s).)
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- 2024
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50. Correlating estrogen replacement therapy and temporomandibular disorders: a comprehensive review following PRISMA principles and cochrane handbook for systematic reviews of interventions.
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Alam MK, Ibrahim MA, Almaslamani MJ, Saeed MH, Siurkel Y, Ronsivalle V, Cicciù M, and Minervini G
- Subjects
- Female, Humans, Educational Status, Pain etiology, Estrogen Replacement Therapy adverse effects, Temporomandibular Joint Disorders complications
- Abstract
Background: Estrogen replacement therapy (ERT) is a common hormonal treatment for postmenopausal women, aimed at alleviating menopausal symptoms and reducing the health risks associated with estrogen deficiency. However, the impact of ERT on temporomandibular disorders (TMDs) remains unclear. This systematic review aims to evaluate the relationship between ERT and TMDs, including TMD occurence, pain, and associated symptoms., Methods: A comprehensive search of seven electronic databases was conducted using predefined search terms and Boolean operators. Inclusion criteria encompassed studies examining the association between ERT and TMDs. Two independent reviewers screened the identified articles, extracted data, and assessed the risk of bias using the RoB -2 tool., Results: Search strategy identified a total of 3 articles which met the inclusion criteria. The included studies investigated the impact of ERT on TMD occurrence and its related symptoms. The analysis revealed no significant association between ERT and TMD occurrence. A significant dose relationship was noted in one of the studies while another mentioned the possible relationship of TMD with educational status. Risk of bias among the studies was low, and the overall quality of evidence was deemed to be high., Conclusion: This systematic review suggests that there is no conclusive evidence supporting an increased risk of TMDs among women receiving ERT. The findings indicate that ERT is unlikely to have a noticeable impact on TMDs. However, due to the limited number of studies available, further research is warranted to strengthen these conclusions and explore potential factors that may influence the relationship between ERT and TMDs., (© 2023. The Author(s).)
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- 2024
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