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19. Modelling Complex Survey Data Using R, SAS, SPSS and Stata: A Comparison Using CLSA Datasets

Author

So, Hon Yiu, Oz, Urun Erbas, Griffith, Lauren, Kirkland, Susan, Ma, Jinhua, Raina, Parminder, Sohel, Nazmul, Thompson, Mary E., Wolfson, Christina, and Wu, Changbao

Subjects
Statistics - Computation, 62-04 (Primary), 62D05 (secondary)
Abstract

The R software has become popular among researchers due to its flexibility and open-source nature. However, researchers in the fields of public health and epidemiological studies are more customary to commercial statistical softwares such as SAS, SPSS and Stata. This paper provides a comprehensive comparison on analysis of health survey data using the R survey package, SAS, SPSS and Stata. We describe detailed R codes and procedures for other software packages on commonly encountered statistical analyses, such as estimation of population means and regression analysis, using datasets from the Canadian Longitudinal Study on Aging (CLSA). It is hoped that the paper stimulates interest among health science researchers to carry data analysis using R and also serves as a cookbook for statistical analysis using different software packages., Comment: There is a data usage issue with the paper and it is requested by the data owner (CLSA) to withdraw the paper at this time

Published
2020

26. COVID-19 and Interdisciplinary Research: What Are the Needs of Researchers on Aging?

Author

White, P. J., Alders, Gésine, Patocs, Audrey, and Raina, Parminder

Abstract

COVID-19 has had an extreme effect on older people. Now more than ever we need collaborative approaches to address complex issues within research on aging. However, the pandemic has dramatically changed the way we conduct, interact, and organize research within interdisciplinary groups. This paper describes a case study of how an interdisciplinary institute for research on aging has managed the process of change during COVID-19 restrictions. A design lead, researcher centered approach was used to understand the needs of researchers as they adapted across 6 months. Firstly, an online survey (n=51) was conducted to understand the scope of change and needs. The survey found broad themes ranging from assistance with finding additional funding to adjusting current research proposals. Following the survey, two Co-Design Sessions were conducted. The first session (n=53) diverged thinking to scope ideas from the survey and actionable themes were created. The second session (n=36) was conducted to converge thinking and focus on solutions based on one of these themes. The results revealed a diversity of ideas addressing the needs of interdisciplinary researchers in aging. These ideas spanned from exploring the capacity to do research remotely and creating virtual collaboration spaces to rethinking stakeholder engagement.

Published
2021
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27. Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases

Author

Chen, Yiheng, Lu, Tianyuan, Pettersson-Kymmer, Ulrika, Stewart, Isobel D., Butler-Laporte, Guillaume, Nakanishi, Tomoko, Cerani, Agustin, Liang, Kevin Y. H., Yoshiji, Satoshi, Willett, Julian Daniel Sunday, Su, Chen-Yang, Raina, Parminder, Greenwood, Celia M. T., Farjoun, Yossi, Forgetta, Vincenzo, Langenberg, Claudia, Zhou, Sirui, Ohlsson, Claes, and Richards, J. Brent

Published
2023
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40. The effect of preprandial versus postprandial physical activity on glycaemia: Meta-analysis of human intervention studies

Author

Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Slebe, Romy, Wenker, Eva, Schoonmade, Linda J., Bouman, Emma J., Blondin, Denis P., Campbell, David J.T., Carpentier, André C., Hoeks, Joris, Raina, Parminder, Schrauwen, Patrick, Serlie, Mireille J., Jan Stenvers, Dirk, de Mutsert, Renée, Beulens, Joline W.J., Rutters, Femke, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Slebe, Romy, Wenker, Eva, Schoonmade, Linda J., Bouman, Emma J., Blondin, Denis P., Campbell, David J.T., Carpentier, André C., Hoeks, Joris, Raina, Parminder, Schrauwen, Patrick, Serlie, Mireille J., Jan Stenvers, Dirk, de Mutsert, Renée, Beulens, Joline W.J., and Rutters, Femke

Published
2024

41. Association of Neighborhood Deprivation and Depressive Symptoms With Epigenetic Age Acceleration:Evidence From the Canadian Longitudinal Study on Aging

Author

Joshi, Divya, van Lenthe, Frank J., Huisman, Martijn, Sund, Erik R., Krokstad, Steinar, Avendano, Mauricio, Raina, Parminder, Joshi, Divya, van Lenthe, Frank J., Huisman, Martijn, Sund, Erik R., Krokstad, Steinar, Avendano, Mauricio, and Raina, Parminder

Abstract

BACKGROUND: Neighborhood deprivation and depression have been linked to epigenetic age acceleration. The next-generation epigenetic clocks including the DNA methylation (DNAm) GrimAge, and PhenoAge have incorporated clinical biomarkers of physiological dysregulation by selecting cytosine-phosphate-guanine sites that are associated with risk factors for disease, and have shown improved accuracy in predicting morbidity and time-to-mortality compared to the first-generation clocks. The aim of this study is to examine the association between neighborhood deprivation and DNAm GrimAge and PhenoAge acceleration in adults, and assess interaction with depressive symptoms. METHODS: The Canadian Longitudinal Study on Aging recruited 51 338 participants aged 45-85 years across provinces in Canada. This cross-sectional analysis is based on a subsample of 1 445 participants at baseline (2011-2015) for whom epigenetic data were available. Epigenetic age acceleration (years) was assessed using the DNAm GrimAge and PhenoAge, and measured as residuals from regression of the biological age on chronological age. RESULTS: A greater neighborhood material and/or social deprivation compared to lower deprivation (b = 0.66; 95% confidence interval [CI] = 0.21, 1.12) and depressive symptoms scores (b = 0.07; 95% CI = 0.01, 0.13) were associated with higher DNAm GrimAge acceleration. The regression estimates for these associations were higher but not statistically significant when epigenetic age acceleration was estimated using DNAm PhenoAge. There was no evidence of a statistical interaction between neighborhood deprivation and depressive symptoms. CONCLUSIONS: Depressive symptoms and neighborhood deprivation are independently associated with premature biological aging. Policies that improve neighborhood environments and address depression in older age may contribute to healthy aging among older adults living in p

Published
2024

45. Effect of Age-Friendly Communities Action Plan on Trajectories of Older Canadians’ Depressive Symptoms Between 2018 and 2020: Multilevel Results From the Canadian Longitudinal Study on Aging

Author

Levasseur, Mélanie, primary, Naud, Daniel, additional, Menec, Verena, additional, Dubois, Marie-France, additional, Wolfson, Christina, additional, Griffith, Lauren E., additional, Trottier, Lise, additional, McMillan, Jacqueline, additional, Généreux, Mélissa, additional, Roy, Mathieu, additional, Couturier, Yves, additional, and Raina, Parminder, additional

Published
2024
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46. The Effects of Cognitive Ability, Mental Health, and Self-Quarantining on Functional Ability of Older Adults During the COVID-19 Pandemic: Results From the Canadian Longitudinal Study on Aging.

Author

Gregory, Madeline A., Schaeffer, Morgan J., Reeves, Jennifer T. H., Griffith, Lauren E., Wolfson, Christina, Basta, Nicole E., McMillan, Jacqueline M., Kirkland, Susan, Raina, Parminder, and Paterson, Theone S. E.

Subjects
COVID-19 pandemic, ACTIVITIES of daily living, OLDER people, COGNITIVE ability, MENTAL health
Abstract

Objectives: Determine whether levels of anxiety and depression, cognitive ability, and self-quarantining during and prior to the pandemic predict decreases in perceived functional ability. Design and Setting: Longitudinal data collected from the Canadian Longitudinal Study on Aging (CLSA) COVID-19 Questionnaire Study (2020) and core CLSA study (Follow-Up 1; 2014-2018). Participants: 17 541 CLSA participants. Measurements: Self-quarantining behaviours from questionnaires administered at Baseline (April 2020), Monthly, and Exit (December 2020) time points of the CLSA COVID-19 Questionnaire Study, levels of anxiety and depression at Baseline, perceived change in functional ability at Exit, and performance on neuropsychological tests (Rey Auditory Verbal Learning Task, Mental Alternation Task, Animal Fluency Test) and functional ability (Older Americans Resources and Services [OARS] Multidimensional Assessment Questionnaire) from the core CLSA study. Results: Greater cognitive ability pre-pandemic (B = −.003, P <.01), higher levels of anxiety (B = −.024, P <.01) and depressive symptoms (B = −.110, P <.01) at Baseline, and higher frequency of engaging in self-quarantining throughout the COVID-19 survey period (B = −.098, P <.01) were associated with perceived loss in functional ability at Exit. Self-quarantining behaviour was associated with perceived loss in functional ability only at average and high levels of depressive symptoms (B = −.013, P <.01). Conclusions: Older adults with higher cognitive and lower functional ability prior to the pandemic were at greater risk of decreased perceived functional ability during the first year of the pandemic, as were those who experienced greater levels of anxiety and depressive symptoms during the pandemic. Strategies/interventions to preserve functional ability in older adults with cognitive independence prior to future pandemics are warranted. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Does urban greenness reduce loneliness and social isolation among Canadians? A cross-sectional study of middle-aged and older adults of the Canadian Longitudinal Study on Aging (CLSA)

Author

Villeneuve, Paul J., primary, Gill, Gagan K., additional, Cottagiri, Susanna A., additional, Dales, Robert, additional, Rainham, Daniel, additional, Ross, Nancy A., additional, Dogan, Habibe, additional, Griffith, Lauren E., additional, Raina, Parminder, additional, and Crouse, Dan L., additional

Published
2023
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