Author: "O. de Divitiis" - Searchworks@Jio Institute Digital Library Search Results

318 results on '"O. de Divitiis"'

1. Da specializzando a neurochirurgo: il percorso formativo in '3D' della Scuola di Neurochirurgia della Federico II di Napoli

Author: V. Meglio, G. Corazzelli, F. Esposito, F. Maiuri, O. De Divitiis, Società Italiana di Neurochirurgia, Meglio, V., Corazzelli, G., Esposito, F., Maiuri, F., and De Divitiis, O.
Published: 2021

2. Raro caso di una metastasi a distanza di un ependimoma mixopapillare spinale

Author: R. Tafuto, V. Meglio, T. Somma, F. Esposito, O. De Divitiis, Società Italiana di Neurochirurgia, Tafuto, R., Meglio, V., Somma, T., Esposito, F., and De Divitiis, O.
Published: 2021

3. Therapeutic and l Diagnostic Path as a tool for handling Cerebral neoplastic disease

Author: R Pacelli, O De Divitiis, G D'Onofrio, R Martello, R Egidio, Maria Triassi, A Marinelli, E Montella, F. Rubba, and R Alfano
Subjects: medicine.medical_specialty, business.industry, Path (graph theory), Public Health, Environmental and Occupational Health, medicine, Neoplastic disease, Radiology, business
Published: 2018
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4. Spinal meningiomas: Age-related features

Author: P. Vergara, O. de Divitiis, Francesco Maiuri, Giuseppe Mariniello, M.L. Del Basso De Caro, Maiuri, Francesco, DEL BASSO DE CARO, Marialaura, DE DIVITIIS, Oreste, P., Vergara, and Mariniello, Giuseppe
Subjects: Adult, Male, Aging, medicine.medical_specialty, Adolescent, Neurofibromatoses, Proliferation index, Gastroenterology, Thoracic Vertebrae, Meningioma, Young Adult, Internal medicine, Progesterone receptor, medicine, Humans, Neurofibromatosis, Rachis, Aged, Retrospective Studies, Aged, 80 and over, Sex Characteristics, Spinal Neoplasms, business.industry, Incidence (epidemiology), Spinal Meningiomas, Histology, General Medicine, Middle Aged, medicine.disease, Spine, Surgery, Causality, Ki-67 Antigen, Treatment Outcome, Receptors, Estrogen, Cervical Vertebrae, Female, Neurology (clinical), Neoplasm Recurrence, Local, Receptors, Progesterone, business
Abstract: Objectives: Spinal meningiomas mainly occur in old patients, with a remarkable female prevalence. This study investigates the different features between younger and older patients in an adult population (>18 years). Materials and methods: A surgical series of 120 adult patients operated on for spinal meningiomas at the Neurosurgical Clinic of the “Federico II” University of Naples is reviewed. In this series 117 patients with a sporadic spinal meningioma were divided in two groups: group I including 30 patients (25.6%) younger than 50 years of age, group II including 87 patients (74.4%) older than 50 years. 3 patients had a spinal meningioma and neurofibromatosis. Several parameters, including sex, predisposing factors, tumor location and growth, histology, recurrences, proliferation index Ki-67 LI, and outcome, are considered and compared in the two age groups. Results: Group I showed an incidence of high cervical spine (C1–C4) meningiomas higher than group II (23.3% vs 3.4%, p = 0.026) and lower rate of thoracic tumors (60% vs 82.7%, p = 0.04). No significant differences of histological type and Ki-67 LI were found. Group I had 2 cases of atypical meningiomas (6.6% vs 0%, ns). Recurrences occurred in 6.6% of group I and 2.6% of group II, with no significance. In recurrent meningiomas values of Ki-67 LI were significantly higher than values in not recurrent meningiomas (p = 0.0001), whereas no difference of estrogen and progesterone receptor expression was noted. Conclusions: Younger adult patients with spinal meningiomas show not rare occurrence of NF (9%) and significantly higher incidence of high cervical and lower incidence of thoracic localizations with respect to the older patients. On the other hand, there are not significant differences of histology, Ki-67 LI and recurrence rate, excepting for a slight difference for atypical meningiomas.
Published: 2011
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5. Trattamento endoscopico di una cisti sintomatica del setto pellucido

Author: Giovanni Grasso, F. M. Salpietro, Michelangelo Gangemi, O. de Divitiis, Francesco Tomasello, S. Lucerna, E. Cardia, and Concetta Alafaci
Subjects: Gynecology, medicine.medical_specialty, Radiological and Ultrasound Technology, business.industry, Medicine, Radiology, Nuclear Medicine and imaging, Neurology (clinical), business, Septum pellucidum
Abstract: Le cisti del setto pellucido sono rare malformazioni del Sistema Nervoso Centrale la cui incidenza nella popolazione adulta è del 15%. Sebbene esse siano generalmente reperti occasionali ed asintomatici poiché spesso comunicanti con il sistema ventricolare, le forme non comunicanti, quando raggiungono dimensioni tali da ostruire i forami di Monro ed il terzo ventricolo, determinano idrocefalo e si manifestano clinicamente con una sindrome da ipertensione endocranica. Gli autori descrivono il caso di un bambino di otto anni con una storia clinica di circa tre anni, caratterizzata da cefalea, labilità attentiva e saltuaria irrequietezza psicomotoria. Gli esami neuroradiologici cui il paziente è stato sottoposto hanno documentato la presenza di una cisti del setto pellucido e del cavum vergae. È stato effettuato un intervento di marsupializzazione della cisti, per via endoscopica, creando una comunicazione tra la cisti ed il sistema ventricolare. Si è ottenuto, così, un rapido miglioramento della sintomatologia clinica ed una riduzione volumetrica della cisti.
Published: 2000
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6. Le complexe nucléaire du nerf oculomoteur de l'homme. Microanatomie et importance clinique

Author: Slobodan Marinković, R. Donzelli, O. de Divitiis, L. Brigante, L. Nikodijecvic, and Francesco Maiuri
Subjects: business.industry, Medicine, Radiology, Nuclear Medicine and imaging, Surgery, Anatomy, business, Pathology and Forensic Medicine
Published: 1998
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7. Risonanza magnetica funzionale: Localizzazione dell'area motoria primaria in pazienti portatori di lesioni espansive cerebrali Risultati preliminari

Author: Roberto Villani, Ferruccio Fazio, M. Leonardi, Giustino Tomei, Lorenzo Bello, Andrea Righini, I. Apollonio, O. de Divitiis, A. Prinster, and Diego Spagnoli
Subjects: 03 medical and health sciences, 0302 clinical medicine, Radiological and Ultrasound Technology, Radiology, Nuclear Medicine and imaging, Neurology (clinical), 030217 neurology & neurosurgery, 030218 nuclear medicine & medical imaging
Abstract: La Risonanza Magnetica Funzionale (RMF) ha dimostrato di poter localizzare la sede di aree corticali funzionali in numerosi protocolli su volontari sani. La identificazione prechirurgica di aree corticali eloquenti è molto importante al fine della realizzazione di un intervento il meno lesivo possibile per la funzione. Il sowertimento più o meno grossolano della regione anatomica da parte di un processo espansivo rende spesso difficile la identificazione di determinati reperi anatomici. Ci siamo proposti di studiare con RMF, su tomografo convenzionale, pazienti affetti da neoplasie intra ed extrassiali che interessavano il lobo frontale posteriore o quello parietale. Sono stati studiati quindici pazienti, tutti destrimani, di età compresa tra i 15 ed i 64 anni. Sono state ottenute mappe di attivazione, che hanno evidenziato aree di significativo aumento del segnale in regione parieto-frontale posteriore. La morfologia delle aree di significativo aumento di segnale era il più delle volte di tipo serpiginoso. Quando l'effetto massa era netto, l'area attivata nell'emisfero patologico appariva dislocata rispetto a quella nell'emisfero controlaterale. Sino ad ora sono stati ripetuti gli esami di RMF dopo l'intervento chirurgico in tre pazienti che non presentavano deficit motori significativi all'arto superiore. Neoplasms compressing or infiltrating cerebral cortex often alter the normal anatomy in such a way that the neurosurgeon can not easily localize and spare functional areas. Moreover, the results of mass effect on brain functional anatomy have not been extensively investigated in vivo yet.
Published: 1995
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8. Cardiac abnormalities in young women with anorexia nervosa

Author: Luca Scalfi, Gian Francesco Mureddu, M. Garofalo, G. Di Biase, Aldo Celentano, Franco Contaldo, G. De Simone, Maurizio Galderisi, O. de Divitiis, P. Tammaro, DE SIMONE, Giovanni, Scalfi, Luca, Galderisi, Maurizio, Celentano, Aldo, DI BIASE, G., Tammaro, P., Garofalo, M., Mureddu, G. F., DE DIVITIIS, O., and Contaldo, Franco
Subjects: Adult, medicine.medical_specialty, Cardiac output, Cardiac index, Blood Pressure, Anorexia, Ventricular Function, Left, left ventricular function, Thinness, Heart Rate, Internal medicine, Mitral valve, medicine, Humans, Mitral valve prolapse, Heart Atria, Cardiac Output, body composition, Mitral Valve Prolapse, business.industry, Anorexia nervosa, medicine.disease, Echocardiography, Doppler, medicine.anatomical_structure, Blood pressure, Endocrinology, Anorexia nervosa (differential diagnoses), Cardiology, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Body mass index, Research Article
Abstract: OBJECTIVE: To identify the characteristics of cardiac involvement in the self-induced starvation phase of anorexia nervosa. METHODS: Doppler echocardiographic indices of left ventricular geometry,function, and filling were examined in 21 white women (mean (SD) 22 (5) years) with anorexia nervosa according to the DSMIII (Diagnostic and Statistical Manual of Mental Disorders) criteria, 19 women (23 (2) years) of normal weight, and 22 constitutionally thin women (21 (4) years) with body mass index < 20. RESULTS: 13 patients (62%) had abnormalities of mitral valve motion compared with one normal weight woman and two thin women (p < 0.001) v both control groups). Left ventricular chamber dimension and mass were significantly less in women with anorexia nervosa than in either the women of normal weight or the thin women, even after standardisation for body size or after controlling for blood pressure. There were no substantial changes in left ventricular shape. Midwall shortening as a percentage of the values predicted from end systolic stress was significantly lower in the starving patients than in women of normal weight: when endocardial shortening was used as the index this difference was overestimated. The cardiac index was also significantly reduced in anorexia nervosa because of a low stroke index and heart rate. The total peripheral resistance was significantly higher in starving patients than in both control groups. The left atrial dimension was significantly smaller in anorexia than in the women of normal weight and the thin women, independently of body size. The transmitral flow velocity E/A ratio was significantly higher in anorexia than in both the control groups because of the reduction of peak velocity A. When data from all three groups were pooled the flow velocity E/A ratio was inversely related to left atrial dimension (r = -0.43, p < 0.0001) and cardiac output (r = -0.64, p < 0.0001) independently of body size. CONCLUSIONS: Anorexia nervosa caused demonstrable abnormalities of mitral valve motion and reduced left ventricular mass and filling associated with systolic dysfunction.
Published: 1994
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9. Classical pterional compared to the extended skull base approach for the removal of clinoidal meningiomas

Author: Giuseppe Mariniello, O. de Divitiis, Francesco Maiuri, Vincenzo Seneca, Mariniello, Giuseppe, DE DIVITIIS, Oreste, Seneca, V., and Maiuri, Francesco
Subjects: Adult, Male, medicine.medical_specialty, genetic structures, Tumor resection, Clinoidal meningiomas, optic canal, skull base, surgical technique, visual outcome, Neurosurgical Procedures, Meningioma, Young Adult, Physiology (medical), medicine.artery, otorhinolaryngologic diseases, medicine, Meningeal Neoplasms, Humans, Aged, Retrospective Studies, Skull Base, Tumor size, Optic canal, business.industry, Pterional approach, General Medicine, Middle Aged, medicine.disease, Surgery, Skull, medicine.anatomical_structure, Neurology, Optic nerve, Female, sense organs, Neurology (clinical), Radiology, Internal carotid artery, business
Abstract: We reviewed a series of 46 consecutive, surgically treated patients with clinoidal meningioma to compare the classical pterional approach (32 patients) to an extended approach including extradural clinoidectomy and removal of the optic canal roof (14 patients). The tumor size and Al-Mefty type, the extension into the optic canal, the time to identification of the optic nerve and internal carotid artery, and the visual outcome were evaluated. Complete tumor resection was obtained in 81% of patients with the classic pterional approach compared to 93% of patients using an extended approach. The extended skull base approach should be used routinely in clinoidal meningiomas >2.5 cm in size, in ones of Al-Mefty type III, and in all patients with tumor extension into the optic canal.
Published: 2011

10. Cerebral blood flow velocity and systemic vascular resistance after acute reduction of low-density lipoprotein in familial hypercholesterolemia

Author: G. Nappi, N. Scarpato, F. Faccenda, Arcangelo Iannuzzi, O. de Divitiis, S. Di Somma, Alfredo Postiglione, Mario Mancini, Agostino Gnasso, Paolo Rubba, Rubba, PAOLO OSVALDO FEDERICO, Faccenda, F, Di Somma, S, Gnasso, A, Scarpato, Nicola, Iannuzzi, A, Nappi, G, Postiglione, Alfredo, De Divitiis, O, and Mancini, M.
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, Blood viscosity, Blood lipids, Hemodynamics, Familial hypercholesterolemia, Hyperlipoproteinemia Type II, chemistry.chemical_compound, Internal medicine, medicine, Humans, adolescent, adult, blood, blood component removal, blood flow velocity, blood viscosity, blood/physiopathology/therapy, cerebrovascular circulation, cholesterol, female, hemofiltration, humans, hypercholesterolemia, hyperlipoproteinemia type ii, ldl, lipoproteins, male, middle aged, vascular resistance, Advanced and Specialized Nursing, business.industry, Blood flow, Middle Aged, Blood Viscosity, medicine.disease, Lipoproteins, LDL, Cholesterol, medicine.anatomical_structure, Endocrinology, Apheresis, chemistry, Cerebrovascular Circulation, Low-density lipoprotein, Blood Component Removal, Vascular resistance, Cardiology, Female, Vascular Resistance, Neurology (clinical), Hemofiltration, Cardiology and Cardiovascular Medicine, business, Blood Flow Velocity
Abstract: Low-density lipoprotein apheresis is currently used for the treatment of familial hypercholesterolemia, an inherited disorder of metabolism associated with premature development of cardiovascular disease. We wanted to evaluate cerebral blood flow velocity, cardiac output, and systemic vascular resistance in patients with familial hypercholesterolemia before and after low-density lipoprotein apheresis. Ten patients (age range, 14 to 46 years; 4 males, 6 females) with familial hypercholesterolemia (8 homozygotes, 2 heterozygotes) and 10 healthy control subjects of comparable age and sex distribution participated in the study. Low-density lipoprotein apheresis by dextran sulfate was performed in 8 patients (7 homozygotes, 1 heterozygote). Six patients (4 homozygotes, 2 heterozygotes) underwent a procedure of extracorporeal erythrocyte filtration with the same extracorporeal volume as for low-density lipoprotein apheresis, but with the exclusion of the passage of plasma through the dextran sulfate column. Cerebral blood flow velocity (transcranial Doppler), cardiac output, and systemic vascular resistance (electric bioimpedance cardiography) were determined by noninvasive techniques before and 1 day and 7 days after low-density lipoprotein apheresis or extracorporeal erythrocyte filtration. Plasma and blood viscosities were measured at the same time. Before apheresis, mean and diastolic cerebral flow velocities were abnormally low in hypercholesterolemic patients (P < .01 and P < .02 vs healthy control subjects, respectively). After apheresis, low-density lipoprotein cholesterol was lowered by 40% to 60% from baseline, and cerebral blood flow velocities (mean, systolic, and diastolic velocities) were increased (P < .01). Cardiac output, systemic vascular resistance, and viscosity values were not significantly modified. Extracorporeal erythrocyte filtration (without passage of plasma through the dextran sulfate column) did not modify serum lipids, hemodynamic parameters, or viscosity values. Low-density lipoprotein apheresis produces potentially useful hemodynamic effects. They are not adequately explained by changes in blood viscosity alone and might reflect a restoration of endothelium-mediated vasodilation, which is inhibited by high concentrations of low-density lipoprotein.
Published: 1993
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11. Myocyte apoptosis and regeneration in the development of left ventricular pressure overload hypertrophy (LVH) in humans

Author: S. DI SOMMA, G. CUDEMO, G. SALVATORE, M. CAPUTO, M. DI BENEDETTO, F. NOVIELLO, C. MAIELLO, G. CAPUTO, M. COTRUFO, J. KAJSTURA, O. DE DIVITIIS, P. ANVERSA, MAROTTA, MARCELLO, S., DI SOMMA, G., Cudemo, G., Salvatore, M., Caputo, M., DI BENEDETTO, F., Noviello, Marotta, Marcello, C., Maiello, G., Caputo, M., Cotrufo, J., Kajstura, O., DE DIVITIIS, and P., Anversa
Published: 1999

12. Coronary vasoreactivity is not altered in young people with type 1 diabetes

Author: Gabriele Riccardi, Arcangelo D'Errico, Gabriella Nosso, Brunella Capaldo, A.A. Turco, Milena Sidiropulos, Maurizio Galderisi, O. de Divitiis, Capaldo, Brunella, Galderisi, Maurizio, Turco, Aa, D'Errico, A, Nosso, G, Sidiropulos, M, de Divitiis, O, and Riccardi, Gabriele
Subjects: Adult, Male, Cardiac function curve, medicine.medical_specialty, Diabetes mellitu, Coronary flow reserve, Endocrinology, Diabetes and Metabolism, Diastole, Medicine (miscellaneous), Blood Pressure, Anterior Descending Coronary Artery, Young Adult, Risk Factors, Coronary Circulation, Internal medicine, Diabetes mellitus, medicine, Humans, Analysis of Variance, Nutrition and Dietetics, business.industry, Microcirculation, Dipyridamole, Blood flow, medicine.disease, Coronary Vessels, Diabetes Mellitus, Type 1, Blood pressure, Cardiovascular Diseases, Case-Control Studies, Linear Models, Cardiology, Female, Coronary microcirculation, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract: Background and aim: Abnormal coronary microvascular circulation has been demonstrated in diabetes and is associated with increased rate of cardiovascular events. Our objective was to evaluate coronary vasoreactivity in young people with type 1 diabetes with and without microvascular complications. Methods and results: Twenty-five type 1 diabetic patients without microvascular complica- tions (DCe), 23 with microvascular complications (DCþ), and 18 control subjects (C) were studied. Coronary vasoreactivity was assessed by means of coronary flow reserve (CFR). Blood flow velocity in the left anterior descending coronary artery was measured at rest and after high-dose dipyridamole using transthoracic color-guided pulsed Doppler echocardiography. CFR was defined as the ratio of hyperaemic to resting diastolic peak flow velocities. The three groups had similar cardiac function parameters, and also systolic and diastolic blood pressure at rest, which remained unchanged during dipyridamole infusion. Resting coro- nary flow velocity was comparable in C, DCe ,a nd DC þ (p Zns). Dipyridamole infusion produced a threefold increase in coronary diastolic peak velocity, which reached similar values in C (0.69 � 0.16 m/s), DCe (0.69 � 0.18 m/s), and DCþ (0.66 � 0.11 m/s). Mean CFR ratio was similar in C (3.33 � 0.66), DCe (3.30 � 0.51), and DCþ (3.24 � 0.60). At multiple linear regres- sion analysis, no association was found between CFR and age, sex, HbA1c, duration of diabetes, and complications. Conclusion: Coronary vasodilatory function is preserved in young D patients, even those with early microvascular complications, suggesting that coronary vasoreactivity deteriorates at more advanced stages of microvascular complications and/or in the presence of other cardio- vascular risk factors.
Published: 2010

13. A comparative study of simvastatin versus pravastatin in patients with primary hypercholesterolaemia

Author: Bruno Trimarco, G. Rosiello, E. Strocchia, O. de Divitiis, Pier Luigi Malini, and S. Di Somma
Subjects: medicine.medical_specialty, business.industry, Cholesterol, Urology, nutritional and metabolic diseases, Placebo, Primary hypercholesterolaemia, chemistry.chemical_compound, Endocrinology, High-density lipoprotein, chemistry, Simvastatin, Low-density lipoprotein, Internal medicine, polycyclic compounds, Medicine, lipids (amino acids, peptides, and proteins), Cardiology and Cardiovascular Medicine, business, Adverse effect, Pravastatin, medicine.drug
Abstract: One hundred patients with primary hypercholesterolaemia (total plasma cholesterol ⩾ 6.2 mmol/l (240 mg/dl)) were enrolled in an open, randomized, parallel comparative study of simvastatin and pravastatin. Prior to entry into a 4-week placebo baseline period, all patients started or continued a standard lipid-lowering diet for at least 6 weeks. Patients were randomized to receive either simvastatin ( n = 50) or pravastatin ( n = 50), both at the recommended starting dose of 10 mg/day, for 6 weeks. With simvastatin, plasma total cholesterol (TC) decreased from 7.59 to 5.80 mmol/l, a reduction of 24%; TC dropped from 7.48 to 6.35 mmol/l during pravastatin therapy. Low density lipoprotein (LDL)-cholesterol was reduced by 33% and 22% with simvastatin and pravastatin and high density lipoprotein (HDL)-cholesterol was increased by 10% and 7%, respectively. The level of total plasma triglycerides (TG) was reduced by 12% with simvastatin and by 6% with pravastatin. All changes were significant ( P ⩽ 0.01) except for the change in TG with pravastatin. Both drugs were well tolerated and the range and the frequency of adverse events was similar for both treatment groups. No patients were withdrawn from the study due to adverse clinical events: insomnia in one patient (a 57-year-old woman) in the pravastatin group required a reduction in dose to 5 mg/day. It is concluded that at the recommended starting dose, simvastatin had a significantly greater lipid-lowering effect than pravastatin.
Published: 1992
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14. Left Ventricular Hypertrophy, Compliance and Ventricular Filling

Author: G. Mossetti, E. Gravina, P. Tammaro, Gian Francesco Mureddu, Maurizio Galderisi, O. de Divitiis, M. Garofalo, and Aldo Celentano
Subjects: Adult, Male, medicine.medical_specialty, Contraction (grammar), Heart disease, Diastole, Blood Pressure, Cardiomegaly, Radionuclide ventriculography, 030204 cardiovascular system & hematology, Left ventricular hypertrophy, Biochemistry, Ventricular Function, Left, Muscle hypertrophy, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Heart rate, medicine, Humans, cardiovascular diseases, Radionuclide Ventriculography, business.industry, Biochemistry (medical), Cell Biology, General Medicine, Middle Aged, medicine.disease, Echocardiography, Doppler, Blood pressure, 030220 oncology & carcinogenesis, Hypertension, Cardiology, Female, business
Abstract: A total of 20 untreated hypertensive patients were divided into two equal groups matched for sex, age and blood pressure but with [mean diastolic wall thickness (MDWT) > 1.2 cm] or without (MDWT > 1.2 cm) left ventricular hypertrophy (LVH). All patients underwent pulsed doppler echocardiography and 99Tc radionuclide ventriculography at rest to assess diastolic and systolic abnormalities. In hypertensives with LVH the interventricular wall thickness, posterior wall thickness and relative diastolic wall thickness were significantly ( P < 0.01) higher and peak filling rate was significantly ( P < 0.01) lower than in hypertensives without LVH. The indices of systolic function, however, were not significantly different in the two patient groups. In hypertensives without LVH peak filling rate directly correlated with heart rate, whereas in those with LVH peak filling rate directly correlated with heart rate and the ratio of peak velocity of early left ventricular filling: peak velocity of late left ventricular filling due to atrial contraction. It is concluded that diastolic parameters may be useful tools for assessing myocardial compliance and may be effective markers of diastolic dysfunction.
Published: 1991
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15. Extended endoscopic endonasal approach to the midline skull base: the evolving role of transsphenoidal surgery

Author: Paolo Cappabianca, O. de Divitiis, Andrea Messina, Luigi Maria Cavallo, Felice Esposito, E. de Divitiis, PICKARD J.D., AKALAN N., DI ROCCO C., DOLENC V.V., LOBO ANTUNES J., MOOIJ J.J.A., SCHRAMM J., SINDOU M., Cappabianca, Paolo, Cavallo, LUIGI MARIA, Esposito, F., DE DIVITIIS, Oreste, Messina, A., and DE DIVITIIS, Enrico
Subjects: Transsphenoidal surgery, medicine.medical_specialty, Endoscope, business.industry, medicine.medical_treatment, Skull, medicine.anatomical_structure, medicine, Radiology, Cranial fossa, business, Sinus cavity, Nose, Brain retraction
Abstract: The evolution of the endoscopic endonasal transsphenoidal technique, which was initially reserved only for sellar lesions through the sphenoid sinus cavity, has lead in the last decades to a progressive possibility to access the skull base from the nose. This route allows midline access and visibility to the suprasellar, retrosellar and parasellar space while obviating brain retraction, and makes possible to treat transsphenoidally a variety of relatively small midline skull base and parasellar lesions traditionally approached transcranially.
Published: 2008

16. Extended endoscopic endonasal transsphenoidal approach to supra-parasellar tumors

Author: O. de Divitiis, Felice Esposito, Luigi Maria Cavallo, E. de Divitiis, Paolo Cappabianca, Dolenc VV, de Divitiis, E., Esposito, F., Cappabianca, Paolo, Cavallo, LUIGI MARIA, and DE DIVITIIS, Oreste
Subjects: Nasal cavity, medicine.medical_specialty, business.industry, Neurovascular bundle, Transsphenoidal approach, Skull, medicine.anatomical_structure, Clivus, Cavernous sinus, Medicine, Radiology, business, Sinus (anatomy), Brain retraction
Abstract: The extended transsphenoidal route, a very versatile approach [13], affords the possibility of exposing the entire midline skull base from below, passing through a less noble structure (the nasal cavity) in order to reach a more noble one (the brain and its neurovascular structures). In contrast to standard skull base surgical approaches, the transsphenoidal technique offers a direct and minimally invasive approach which provides excellent midline access and visibility into the suprasellar, retrosellar and retroclival spaces, obviating brain retraction [9, 13, 14, 27, 34, 36, 37, 39, 42, 49, 52. Owing to its location, the cranial base extending from the posterior planum sphenoidale to the upper two-thirds of the clivus may be exposed through the sphenoid sinus so long as it is sufficiently pneumatized.
Published: 2008

17. Cytoskeleton Defects and Contractile Dysfunction of Myocytes in Hypertensive Patients following Cardiac Transplantation

Author: S. DI SOMMA, G: SALVATORE, F. DE VIVO, M. . MAROTTA, A. CAROTENUTO, C. MAIELLO, F. NOVIELLO, G. CUDEMO, G. C. UDA, M. COTRUFO, O. DE DIVITIIS, CAPUTO, GIUSEPPE, S., DI SOMMA, Caputo, Giuseppe, G:, Salvatore, F., DE VIVO, Marotta, M., A., Carotenuto, C., Maiello, F., Noviello, G., Cudemo, G. C., Uda, M., Cotrufo, and O., DE DIVITIIS
Published: 1997

18. Coronary flow riserve in patient with mild thyroid hormone deficiency'

Author: L. Pagano, M. Pulcrano, S. Ippolito, A. Rossi, A. D’Errico, M. Sidiropulos, GALDERISI, MAURIZIO, O. De Divitiis, G. Lombardi, BIONDI, BERNADETTE, L., Pagano, M., Pulcrano, S., Ippolito, A., Rossi, A., D’Errico, M., Sidiropulo, Galderisi, Maurizio, O., De Divitii, G., Lombardi, and Biondi, Bernadette
Published: 2007

19. Coronary flow riserve (CFR) in Patient with Subclinical Hypothyroidism'

Author: BIONDI, BERNADETTE, L. Pagano, M. Pulcrano, S. Ippolito, A. Rossi, A. D’Errico, M. Sidiropulos, GALDERISI, MAURIZIO, O. De Divitiis, G. Lombardi, Biondi, Bernadette, L., Pagano, M., Pulcrano, S., Ippolito, A., Rossi, A., D’Errico, M., Sidiropulo, Galderisi, Maurizio, O., De Divitii, and G., Lombardi
Published: 2007

20. 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004

Author: S. Artigas, A V Dreval, Mark I. McCarthy, C Watson, Peter H. Bennett, M Quint, Y Ikeda, E Alpert, F Schiele, H Sekihara, Erik Gylfe, P Lowe, J Kuhlmann, Alain Golay, V Longo, Shahidul Alam Khan Akm., L G Mantovani, M Zawodniak-Szalapska, G Winkler, T Harrity, L Virág, U Johne, Kuo S-W., Linda C Tapsell, J Rodriguez, Michel Komajda, K Kankova, Carole A. Cull, M Sporna, E Estilles, U Ribel, M C Spruce, E Buzzigoli, T Prazak, J K McLaughlin, M K Lingohr, M Lim, F Calara, A Siebenhofer, G Meregalli, Roberto Anichini, A D Baron, R Kurashvili, P C Butler, G I Fantus, T. E. De Gooyer, Park Y-M., R. Walther, S Heinrich, Agnieszka Zawiejska, S Mukherjee, Nikolaos Papanas, G Wong, Ian D. Caterson, David M. Maahs, Shuichi Kaneko, Alexandra E. Butler, Francisco Javier Ampudia-Blasco, O N Kong, Attali J-R., C A Hedman, K Oshinyemi, Nicolle Müller, I C Cranston, N Okumus, M V Vlaiculescu, Balasubramanian Ravikumar, W W Cheatham, K Mukasa, K B Biswas, Annunziata Lapolla, Phil McEwan, G Mader, Gilles Chassot, Dragi Anevski, Werner A. Scherbaum, M Donath, C Hesselmann, R A Gandhi, David E. Moller, Ezio Bonifacio, C Garcia, V Ifandi, P Hornnes, Nieuwenhoven Fav., C Puech, S Pérez-Del-Pulgar, Kim S-R., G Hines, C Rubio Terrés, Michael Gaster, N. Hosszufalusi, A Scholze, Andrew A. Young, Stavros Liatis, F Hariri, S Tan, Paul Valensi, Allan E. Karlsen, J Kim, E. Moberg, J Kaiser, L Berman, G Nelson, A Altkrüger, P Kothare, D B Cook, S Doran, G. van Dijk, Shahnaz Shahinfar, Kim C-S., P Stahl, M Manousaki, S Sigrist, S K Lim, M. P. Stern, A Guberti, C Rezzani, J McKenney, Karl Thomaseth, Sofia Carlsson, M Julia, R Brillante, I Rubesova, T Darkow, E Matsumoto, Wendy M. Macfarlane, M Di Martino, G Bardini, Rossella Menghini, D Duhot, E Farcasiu, Annalisa Natalicchio, I Lindner, J Buvat, Christian L. Brand, Harry Dorchy, Iwona Pietrzak, Z T Luo, P Home, M Ekelund, Jesper Gromada, Kristine Færch, F Piarulli, H Kim, R Mentel, Zsuzsanna K. Zsengellér, Dullaart Rpf., Anton Luger, Thomas A. Pearson, V Manicardi, P Rösen, Feng Y-M., R Morganti, Lars Hansen, Demuth H-U., Haruo Kasai, A Shostak, Rudi Steffensen, G Taylor, Markolf Hanefeld, C Santini, E Hamaguchi, Roberto Miccoli, F Storms, M Cooper, Y Lee, Allison E. Aiello, P Smith, T Suehiro, K Treece, M Waluś, Timothy A Welborn, Simone Baltrusch, E Kontela, S Chai, J Crean, H Yokoyama, Johan G. Eriksson, Rafael Hernández Hernández, J Rodríguez-Saldaña, M P Tornero, G Formoso, D. Lovell, E Bingham, A Mylonakis, M Manteghetti, D Fedele, Antonio Martín-Duce, Ralph A. DeFronzo, D Salcedo, Kurt Højlund, Antonio Petrone, Sheu Whh., C Gutierrez, Flavia Pricci, S Kurita, Z G Abbas, M M Benedetti, Philippe A. Halban, Daniel J. Cox, O Ljungkvist, Justine Davies, J Palsgaard, Lars Sjöström, E Bosi, L Janin-Manificat, W. F. Kelly, M. Fernandez, E Colak, O V Mulyarchik, B Kronshage, F Lang, M Erfurth, Takashi Kadowaki, N Jendrike, U Walter, J Wishart, Y. Neye, D Kim, N Furuhashi, M Barsotti, D Florow, L Ke, L Borgquist, N C Jackson, Ffolliott M. Fisher, V Baskar, K Yoshioka, Bryan A. Wolf, G Chabrier, R Skoumal, Livio Luzi, H Kose, I Pharisien, B. Klein, H Winiarska, M C Johnson, L Griffiths, Nonna Kravchun, C Combe, Baptist Gallwitz, J Zdychova, L Skorda, Jorma Ilonen, W Gao, I N Steen, A Terrinoni, P D Ambery, W Kern, C M Kusminski, Cho M-H., Paolo Pozzilli, Louise G. Grunnet, E Schönle, David R Matthews, Robert W. Taylor, Y Cohen, Kim H-S., M P Eccles, N B Tutuncu, D McDowell, Richard M. Bergenstal, K Takamatsu, T Steiner, Jaan Palgi, Valdemar Grill, N Niculescu, G Federici, S Lehto, P. M. McKeigue, M Barone, Michael E. Trautmann, S Smirnov, J Mannion, M Eto, C Rousseau, M Conti, C S Ernest, Antonio Ceriello, D H Schweitzer, Jung E-D., Andreas Festa, Avijit Lahiri, A Shepelkevich, A Murro, A Kollmann, Jonathan R.S. Arch, R Landgraf, Son H-Y., I Engelsberger, E Agardh, S Rodríguez-Mulero, P J Kraml, K Lee, D. F. Du Toit, E Kim, G Fadini, Williams Ajk., Philip Home, M B Antcieferov, C Perlemoine, D Perrea, Song X-L., D Ruggieri, Krister Bokvist, Heidi Sørensen, Bilbao, G Yoshino, J P Taylor, Shen H-M., S M Furier, R Urquhart, J Wohlgelernter, Jianping Weng, T. Baba, Q Hong, C Silva, Castaigne J-P., M Felaco, X X Zhang, M Jaroň, Milla Rosengård-Bärlund, J G Papp, Toshio Miyata, Lervang H-H., Park M-K., I Kinalska, A Long, Oomen Phn., N Kogawa, Ippolita Patrizia Patera, S. Karadeniz, Dinesh Selvarajah, D S Chung, A Wensaas, Richard Imrich, M Recasens, J Ruxer, O Buchea, E Wilpart, S P Stepanenko, Le Ttd., H Ohgawara, Mariaconsuelo Valentini, A Mondok, M Peltonen, Marianne O. Larsen, K Chatzianagnostou, Agneta Ståhle, A L Ferrari, L Bordier, F Maingrette, A Matsuda, G Vukomanovic, Jakob D. Wikstrom, T Yamakita, E Gorostiaga, J Jin, B Gopalan, Heinz Drexel, S Hewitt, Rury R. Holman, C Dieterle, T L Ruchti, N Asatiani, M Sidira, A Iezzi, A J Sommerfield, D Châtenet, M L Olsen, R Bergemann, C Koehler, T L Kuraeva, B Balas, Christian Berne, E Santos-Mazo, G Smith, A Siejka, R Kožnarová, A Mattina, S Sheikh, A Adomeit, M Rasmussen, J. Fagerudd, N Busciantella Ricci, Nuria Vilarrasa, E Hammar, T L Thoms, L Aydın, Ron G. Rosenfeld, A Nikolajuk, R Gos, C L Morgan, H L Yu, D Dheelchand, S Ramrath, N Boudriga, Jerome I. Rotter, C Jahannault, W M Weston, Folke Lindgärde, M Hertlova, D Knight, A Monroy-Mayorga, E Pardini, A Chamson-Reig, B Franke, Janie McCluskey, Joseph Bryan, C Nikolopoulou, Christie M. Ballantyne, Fausto Santeusanio, L Pegoraro, M Lee, A Klimenko, S Jaiveer, K. Pettersson-Fernholm, Michael A. Nauck, A Ekbom-Schnell, G Deferrari, Riccardo Schiaffini, S. Pampanelli, Khan Aka., David Hopkins, Maija Wessman, M Kamarinos, Noh J-H., O Ebisui, K McCarroll, Jeppe Sturis, Peter Nowotny, N Gorbenko, Åke Sjöholm, David G. Maggs, A E Halseth, B Cresci, A A Ortiz-Gress, A Korakovouni, O Matejkova, C E Mogensen, C J Lin, Ramon Gomis, H Seaman, C Granier, Yang C-H., F Assah, O Sanchez, Fausto Machicao, Peter G. Morris, Alberto Ortiz, A Giardinelli, D Bracaglia, A Gonzalo, S Pavlatos, Andreas Lechner, F Canovic, L Sjolind, Allan Vaag, Birgitte Bruun Nielsen, David A. Ziegler, Vito Lampasona, R Gershoni-Baruch, A. Dei Cas, H Renz, E Mena, Matthew Waltham, Kim D-M., H Levanen, D D Mick, Valentina Alexandrovna Peterkova, E Meskhishvili, Sarah Nutland, R Bustani, John R. Lindsay, M Christoforidou, A Abicht, E Harno, K Cyganek, A Fitchet, S Neelotpol, P Nikishin, P Serradas, J Hinrichsen, M Halvorson, M Chovatia, B Voet, Jinny Willis, E Parretti, M Haslbeck, M Wellard, L Teng, Julio Wainstein, J S Fischer, K. Lalic, D Roggenland, I Gich, R Anwar, Maurizio Cassader, D Serota, X J Li, R J Schotzinger, Vilmundur Gudnason, Björn Zethelius, S A Wootton, W Andrzejewski, R Rezsohazy, R Gao, T Klimentova, T Mazurek, I Bruckner, C Dohrmann, R E James, G daSilva Xavier, Kim S-Y., A Dorca, Stuart J. Pocock, Terri J. Allen, I Giovos, P B Parab, N H Andersen, P Fotinakis, Miriam Cnop, H Lee, Norbert Tennagels, Omorodola I. Abatan, F Ailett, I. Lager, D Manzella, H Hut, Larry A. Distiller, G Lip, Lim S-K., Rong Zhang, T Tsuno, Steen Knudsen, M. Bajardi, Manuel Benito, Dai Sugimoto, Melvin J. Prince, D W Dunstan, D Rankins, K A Majali, G Ozansoy, Isabella Russo, S Uçak, G Annuzzi, R Talar-Wojnarowska, K Lange, S Neugebauer-Baba, Campbell H. Thompson, Eric Renard, P. D. Mountjoy, Z Morrison, Elizabeth A. Davis, Franco Cavallo, C Corvaja, R Antuña, Craig John Currie, H Linnebjerg, He Y-L., A J Palmer, Mariola R. Chacón, H Malinska, M. Jones, R Lichnovská, K Mandes, Paolo Tessari, T Mokhort, A Laina, H. L. Y. Chan, I Schmidt, R Banks, Richard G. IJzerman, L Ksinantova, G Setti, H Vaudry, A Gallo, V Spallone, Chen J-W., Thomas Danne, A Chong, M Hallschmid, S Aczel, S Hulme, N Islam, M Hosoi, P M Ternan, P Di Bartolo, N Bishara, T Shibasaki, Martin A. Osterhoff, Im S-S., M Jecht, T Hamaguchi, S Mattera, K Ways, Elizabeth Northam, U Rajala, Reinhard W. Holl, L Yang, S Panaiotopoulos, K Horvath, R Kluge, Thora B. Bodvarsdottir, Y Dong, Irene Alemanno, C McDougall, Reimar W. Thomsen, M Campbell, W Rabl, John Öhrvik, Yuichiro Yamada, Paola Ungaro, W Benzer, Mike Sampson, Roberto Trevisan, R G Radu, Aas A-M., P E Lobo, Ricardo Scott, S M Son, Josephine M. Forbes, T A Hillier, K L Wyne, Louis L. Nguyen, J Farmer, M H Tan, Kwon H-S., J Yang, L Sandvik, Franco Folli, A K Jenum, M Nguyen, W Pratipanawatr, A L Frederiksen, Rebecca Smith, Lee H-J., A Schäfer, C Manuelli, G S Denver, T Vukovich, B Maceira, K Matsumoto, K. Chokkalingam, Nurcan Üçeyler, P Modi, Timothy M. Morgan, S Mertens, B M Singh, Michaela Riedl, K Iso, C Cucurullo, G. F. Bottazzo, M Calvani, K Hur, J Wetzels, Kazuhiro Takahashi, Y Aso, H Stammer, M G Masding, Fitsum Guebre-Egziabher, J L González-Sánchez, L Armstrong, Alberto Maran, Peter G.F. Swift, S S Popovic, J Starczynski, E Vitacolonna, Luigi Laviola, R W Gelling, Marina Cardellini, D Barilla, Rosa de Diego Martínez, W H Landschulz, Anne Mette Rosenfalck, R K Wong, Kevin E. Schneider, K Peros, Giuseppe Nanni, F Zhang, I Rákóczi, T Iburi, M Nakhjavani, X Q Zhang, S Tournis, Per Lav Madsen, Graham A. Hitman, A. Tura, K Laubner, N D Kostic, Lawrence M. Dolan, R. Sinha Roy, J A Wagner, J. Tuomilehto, J Hauptman, M Abdel-Ghany, D Lacombe, Toralph Ruge, Johannes A Maassen, Triantafyllos Didangelos, K Sasaki, I Argüelles, Klaus Levin, C Popow, Emanuel Christ, R Chetty, L Baillet-Blanco, Jo-Ann Salmon, T Mine, James L. Trevaskis, I Franke, J Gorski, E A Andrianova, A Dayan, A Caballero, Aleksandra Gilis-Januszewska, M Yasujima, Z Kasalová, C.D.A. Stehouwer, F. K. Gorus, G A Nichols, A Glowania, David P. Strachan, P Fredlund, N. F. da Silva, P Reboldi, M Sausbier, K H Groenier, G Stuccio, N Guttman, K R Ahmed, A D Ristic, T Kapellen, J Coutcher, Aldo V. Greco, Oswald Wagner, A Zagayko, Maria Alevizaki, B B Zhang, W F Ferris, Jenny Fredriksson, Lois Jovanovic, J Hänninen, R De Giglio, Kazuo Yagui, O Potterat, P Hamliton, R E Scranton, B Mankovsky, A Stylianou, B Fellström, Abdel-Wahab Yha., M Kitagawa, Katherine L. Baldock, F R Johnson, F Baigts, S D'Addato, F J Sanz, A Mistry, S D Wise, T Pratipanawatr, U R Fölsch, James R.C. Parkinson, Claudia Sommer, C Park, F E Griffiths, M L Martí, R Demirtunc, S Taniguchi, J Lundkvist, T Siegmund, Juan Sztajzel, C Dienesch, F Baumgartner, L Scalone, T M Mckolanis, K Otake, Ullrik Pedersen-Bjergaard, T M Vriesendorp, Michael B. Wheeler, Henry Schmitt, Peter Hovind, S Lange, Stephane Roze, L. Van Gaal, B Klaproth, Anthony E. Civitarese, D Eckland, A Dagar, D F Hopkins, Kari Stefansson, C Gonzalez-Yanes, B Meyboom-de Jong, D. J. Betteridge, K Buhling, M Crepaldi, Ana M. Wägner, L Renna, L Volpe, R McBride, V Corbo, E O Brennesvik, R P Hayes, R Abdollahnia, G Viviani, C F Liew, Francisco Pérez-Bravo, Jeffrey Baron, Brian M. Frier, H H Samira, D Szentendrei, K. J. Schjoedt, W K Waldhäusl, D Gniuli, D Zou, G Tschank, V Urbančič, A L Nolan, Albertini J-P., J Malcomson, M Larbig, C Cheyssac, K Aurich, C M Kesson, S Heller, Maija E. Miettinen, R F Luco, Adrian J. Cameron, Luigi Mattiello, Z. Metelko, X E Zhang, M Parramón, I. G. Obrosova, J Fruchart, M Ilic, Björn Eliasson, Gilles Chatellier, M A Martín, D M Kendall, Holger Luthman, V F Varillas, D Maccubbin, Jang S-A., Amalia Gastaldelli, E Salzsieder, P. de Mol, A Yoshida, H D Lindner, D Gostiljac, M Just, Pan C-Y., J M Fujitaki, G Eiermann, K Bergenheim, A D Frick, A Agacdiken, K Varytimiadis, K Cseh, D A Jackson, S Calderari, Dena G. Hernandez, H M Liebich, K Min, F. de Zegher, Bernd Kulzer, K Han, Ulrich A. Müller, D Marrero, H Hatakeyama, René Koopman, Doo H-K., Petr Wohl, P. Sharp, P Forder, Thor Aspelund, N Meneveau, R M Schmülling, R Aubert, Thom Sam., H Youshikawa, M Ankelo, D Bowden, I Kelly, Frédéric Fumeron, M Sartini, Robert S. Sherwin, L Varadhan, A Criscimanna, John Betteridge, V Jelic, M Bartnik, N Lemke, B Ursø, A Bertoldo, A M Owona, H Okochi, L Pérez-Tamajó, S L Monfre, Daniel Brandhorst, K T Legg, Andries J. Smit, Veronica Sancho, Masashi Hirai, C Klein, Paul J. Thornalley, A Chaidaroglou, K Miura, B Zinman, O M Dvoynishnikova, J Plank, Jan Bolinder, C Lush, B Rubi, R Pozzilli, M Bashir, S A Shtandel, F Mosca, A Naskalska, Josef Vcelak, U Sausbier, P Cavaiani, T U Baehring, Michele Solimena, P Formisano, M Rastaldi, Bernard Thorens, J Ruzzin, E Arbit, M. Hori, Torkel B. Brismar, E Soltes Rak, A Filo, P Heinke, Matthew P. Coghlan, M Masotti, I Perevozskaya, K Ahn, I Moules, K Van Dyck, I Goldstein, Z Mathe, G Z Zhao, S Fajardo, J Taylor, S Chrul, J C Pareja, D Hadjidakis, A J Scheen, N Siddiqua, D C Cavan, R Grella, Krabbe S, H J Rochlitz, A E Hinkkanen, W Wilpshaar, Richard Stevens, M Dreyer, S Hara, X Wang, Melania Manco, D Gillen, Magalie A. Ravier, Olli Simell, John C. Lawrence, Kohnert K-D., Agardh C-D., A Berghold, L Kristensen, Grant Sfa., N Gursoy, Leif Groop, N Freemantle, Anja Schweizer, L Pala, Legros J-J., C. Di Pietro, N. Yamamoto, J Magyar, B Nikolovski, H Ikeda, D Lee, Bruce A. Buckingham, A O Wollitzer, I Kennedy, C Ernest, Neville H. McClenaghan, S Tanaka, Asimina Mitrakou, T Heinze, W Kerner, Moeenaldeen Al-Sayed, Charles Thivolet, L Klaff, A Miconi, Cristina Valeri, J. O. Christensen, K. Ekberg, A Jardine, T Endo, X Zhang, D F Child, A Kienitz, D K Seidel, H. Tada, Sylvie Abouna, Cyrus Cooper, Catherine R Chittleborough, Roberta Assaloni, S Corbi, A K Bose, K Ozawa, C Ahn, K A Deans, G Jackowski, Martin Gibson, Patrick McElduff, O A Mojiminiyi, Manuel Serrano-Ríos, O Dupuy, A L Davydov, Iwar Klimes, Sten-Anders Ivarsson, N Ichino, R Matsutomo, E R Smith, A Stefanovska, B Dehmel, K Koniavitou, E Agascioglu, M Hatazaki, J. M. Gibson, T Yada, P Ribaux, M Rupnik, K Fridell, G Scutaru, L Chugunova, Henrietta Mulnier, A Kendereski, H Lehnert, C Billi, M Sobczak, Francisco M-Mj., L K Archibald, S Sukumvanich, David B. Dunger, I. Benke, G Yillar, N Stingemore, J. M. Boavida, Y Shi, Jimmy D. Bell, L Bozzetto, Andrew J. Ahmann, E Jebens, J Keiding, Elena Henkel, Mark Fineman, J F McRae, Carol Forsblom, S Martemucci, Lourdes Ibáñez, P G Prieto, L Ringholm Nielsen, S Pratas, B von Stritzky, Julio Rosenstock, Lee K-W., J Stocks, L J Strow, I Samarguliani, L Wennekes, R Cheung, Abhishek Nag, Roberto Gambino, Y Suleymanoglu, E Murphy, T T Durck, M F Peyrot, Y Unno, Alexander Mayorov, Eleuterio Ferrannini, D. C. Rao, D Neely, H Karunajeewa, J Palmisano, Julia B. Lewis, M Ravid, G Pons, E Junca, P Vexiau, S Sailesh, D K Miloslavskiy, O N Bondarenko, U Smith, S Torri, Constantine Tsigos, Cesario Bianchi, Mattia Locatelli, D Jaquet, Virpi Lindi, M Moroi, M E Tushuizen, P Pelicci, R Scognamiglio, Pal Pacher, S M Thyssen, A Péterfalvi, Y Ho, S Guntram, L Romics, T Nakagami, Clive S. Cockram, Irina Kowalska, K Brodbeck, Gojka Roglic, J. Dörig, Lise Tarnow, Therese Tillin, A López-Alba, Martin Krššák, Moses Elisaf, S Hata, D P Snoeck, D Schmoll, O V Udovichenko, A Scaramuzza, J Paul, John H. Fuller, Nicholas Katsilambros, Michele Muggeo, Pia Ekbom, Piero Marchetti, V Melki, C Bailleau, H Stavrianos, A D'Errico, Geremia B. Bolli, Amabile Maier, Kelter A-R., Anders Green, Q J Morélis, Steffen Thiel, C Watkins, R C Cheung, A Clark, Elvira Fioriti, N Ari, Nam J-Y., Y Cottin, L G Krinelke, H Al Mohammedi, Simon C. Fleming, C Jones, Z Kerényi, Ahn Y-H., Meile M-J., P Nánási, M Graner, V Canonico, Gangnerau M-N., Hugh R. Taylor, Giovanni Sartore, A. Dejgaard, Carol Kelley, S. Ali, Stéphane Dalle, Jeffrey S. Gonzalez, Elena Šeböková, Alexander Beck, Ingo B. Leibiger, M Rosu, C Pencea, Werner Waldhäusl, Kaltenbacher M-C., R Butzer, S Thore, Adam G. Tabak, Angelo Avogaro, E Standi, Boris Kovatchev, O Bradescu, Patrizia Dentelli, A Fujita, C Verri, R Chlup, Prasad Ydm., S V Hörsten, van der Merwe M-T., D Hilliard, W Klein, D Worthley, M Udvardy, Berit R. Jensen, A D'Avanzo, J Monaghan, K P Yeo, Guivarch P-H., B Bauduceau, D Weghuber, P Tatti, J Ybarra, S Gwozdziewiczová, E Gasparini, B Saltin, Charlotte Granhall, Howard Leventhal, R Marin, M Tumiati, Cicero Afg., L Csémy, B Berger, S Mikros, D Dall'Asta, M Shahmanesh, Y G Vasiljev, F Potthoff, H S Randeva, G De Berardis, J O Logan, K Warncke, P Uitterlinden, E Rehring, K Gilmore, K Shankhdhar, V V Bojko, M Vahatalo, E A Korolyova, D Wiemann, P G Lankisch, D Hendrie, F Galtier, M Rybarczyk, Gisela Dahlquist, N N Rudovich, G Stein, A Liebl, F Tan, A Westerlund, S Gronemann, I Franklin, Jonathan A. Prince, Peter Arner, E Skliros, T. Sparre, M Vigas, Maddalena Trombetta, L. Bjerre Knudsen, A C Sima, I Dubroca, Alastair Gray, I Weets, R Ferraresi, Schauer Ujw., E. Leinonen, S Corazza, Jonathan Levy, P K Prakash, R Guzder, S. Barnhill, John Blangero, J Herreros, G. de Vries, Cheng Ptw., A Macías-Batista, K. Capito, R Thomas, G Thomas, G Boemi, Lotte Pietraszek, Pierre Fontaine, I Holme, J Smedegaard, C A Harrop, U Helwig, B Levy, A P Gribben, Hiroto Furuta, P Beckett, S Giannini, Ruth L. Coleman, Eva Fernqvist-Forbes, N Cugnardey, A Dumas, Jane Pinaire, S E Hofer, D Shimono, Erik H. Serné, Alain D. Baron, C Battista, M Tanen, M Klementova, V Adams, J Komorowski, Antonio Nicolucci, E. C. Burns, H Sydall, M G Fanara, M G Giovannitti, N Okabayashi, Magdalena Szurkowska, I A Eroshkin, M. I. J. Uusitupa, D Ma, C C Dieguez, J Sutcliffe-Goulden, A V Gaddi, Michał Arabski, Serge Halimi, Wendy C. Burns, S Seclén, H Sugano, A Vinterby, K Backx, L F Diaconu, Fernando Gomez-Peralta, O'Harte Fpm., G Lepeniotis, D Laune, H Kvasničková, N H Wallén, G Boner, G Cieślik, Robert Hermann, Paul Q. Thomas, Y Kumon, Maria Maiello, M Atkins, Kenneth A. Earle, Guowang Xu, H Y Bae, I Reynisdottir, D Perez, D E Cannon, P Fabietti, I Geronooz, J Østergaard, K J Jeitler, S Skourtis, A Zambanini, A Saemann, K Kuboki, Helen L. Lutgers, A C Thai, Arne Melander, D Pinkowski, S G Straub, S A Wolfe-Coote, A Totora, Hayley Dickinson, A Lindenmair, A Ginis, I Faturos, F Van Eylen, C Huard, F Fu, N Wang, B M Rasmussen, Angela Napoli, L Granato, Markus M. Lerch, M. Frandsen, A Lyras, Lawrence S. Phillips, J Mabley, R Goldschmeding, B K Kilhovd, W Liu, Greg Poffenberger, P Cipriano, Anna Maria Charlotte K Lindqvist, A Matsuzawa, J Wang, T Yu, M S Pepper, Lena M. Thorn, Y Sakamoto, Blanche Schwappach, Anna L. Gloyn, P Dupraz, A. M. Schmidt, M Psallas, V Tsirimbis, Carl D. Langefeld, D Sass, H E Scholtz, M. Cailleau, Lauren Julia Brown, K Phillips, M. Iezzi, C Jayawarna, Eleni Anastasiou, R Lobmann, R Lundershausen, H Fujiwara, H R Nan, I C Smith, I A Karpova, A Navazio, S Kang, T. Hansen, T Watanabe, Gang Hu, Malik Rja., T Kennedy-Martin, Ulla M Smidt, J.M. Dekker, A A Fisher, H Liu, R E Pratley, B Sun, C Fledelius, J F Raposo, R Langham, Ahn S-Y., B R Waterhouse, Shaoping Deng, W Ricart, S V Melnichenko, Henrike Sell, M. Tomalino, N Takeda, Paola Massucco, A Harlan, W Henrich, C D Byrne, R Junik, Khalid Hussain, D Pop Gorceva, Torben Hansen, C Ritterath, K Ogawa, D V Phan, Bradley S Metcalf, Robb E. Moses, Juan P. Frias, Hitoshi Ishii, C Brisard, P Wolkow, H H Maurer, Ingo Rustenbeck, Juris J. Meier, Octavian Savu, S D Lin, V B Bregovski, A Fox, S Cicala, M. Koenen, L Vignati, O de Divitiis, Constantin Ionescu-Tirgoviste, Kilian Rittig, J Song, Riccardo Candido, F Cohen-Boulakia, U Shankhdhar, P Jahan, Antonio Tiengo, E Liepinsh, C Álvarez, Sigurd Lenzen, James E. Foley, A. del Arco, M A Maitan, U Mollenhauer, M A Na, A Beha, B Aicher, Gabriele Meyer, E Sommariva, J Åman, B Gmeinhart, Theede A-M., Bjorn Bolinder, Giulio Ceolotto, S Sbrana, F Biarnes, Damini Dey, Barbara Thorand, H H Klein, Juliana C.N. Chan, L Piconi, S Gudbjornsdottir, E Bobbioni-Harsch, Joanna Polanska, Cristian Serafinceanu, S Gambardella, Olivier Huber, J D Brunzell, T Nagasawa, Loretta Vileikyte, A Szocs, H Löwel, Z Lin, Anders Juul, H Tsuneki, L Sauriol, G Siebert, Marit E. Jørgensen, K Matthies, Brian D. Green, P Jurowski, Z Gao, M Furuya, Silvia Manfrini, Efthymios Motakis, E Souvatzoglou, Qian Y-Z., Byun S-H., T Nguyen, M R Anwar, Geltrude Mingrone, B. Idzior-Walus, Mamas A. Mamas, G Scholl-Schilling, C Bittner, A E Raptis, L Laghi, Murray Stewart, M Orel, Janet M. 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D, Torjesen, P, Kilhovd, B, Berg, T, Sandvik, L, Hanssen, K, Mentink, C, Donchenko, G, Stepanenko, S, Maingrette, F, Deng, H, Lindenmair, A, Freudenthaler, A, Baumgartner parzer, S, Nizheradze, K, Khoruzhenko, A, Tronko, N, Sheu, W, Ou, H, Shen, H, Lin, T, Wu, H, Yang, C, Mogylnytska, L, Schmoelzer, I, Davies, J, Band, M, Struthers, A, Prázný, M, Škrha, J, Kasalová, Z, Neelotpol, S, Jahan, P, Kauschke, S, Harrop, C, Schäfer, A, Widder, J, Eigenthaler, M, Walter, U, Uchimura, I, Ikebukuro, M, Kaibara, M, Hirata, M, Helal, R, Pervin, F, Yang, X, Jansson, P, Nagaev, I, Jack, M, Carvalho, E, Sunnerhagen, K, Cam, M, Cushman, S, Smith, U, Creely, S, Farmer, J, Gustafson, B, Kusminski, C, Krusinova, E, Wohl, P, Klementova, M, Lanska, V, Mcdougall, C, Kelly, I, Abbas, Z, Lutale, J, Archibald, L, Karunajeewa, H, Stingemore, N, Stuccio, G, Mcgechie, D, Muller, L, Hak, E, Goudzwaard, W, Montorsi, F, Homering, M, Sprenger, K, Goldstein, I, Asnaghi, V, Ferrari, G, Rastaldi, M, Gabellini, D, Dell'Antonio, G, Maestroni, A, Ruggieri, D, Luzi, L, Piemonti, L, Zerbini, G, Anafaroglu, I, Tutuncu, N, Sultana, M, Siddiqua, N, Iwasaki, T, Nakajima, A, Yoneda, M, Mukasa, K, Tanaka, S, and Sekihara, H
Subjects: 0303 health sciences, medicine.medical_specialty, business.industry, EASD, Endocrinology, Diabetes and Metabolism, Human physiology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Family medicine, Internal Medicine, Medicine, business, 030217 neurology & neurosurgery, 030304 developmental biology
Published: 2004

21. Desmin-free cardiomyocytes and myocardial dysfunction in end stage heart failure

Author: Salvatore Esposito, M Di Benedetto, P. La Dogana, F. Ferranti, L. De Santo, M.I. Scarano, S. Di Somma, Maurizio Cotrufo, O. de Divitiis, L. Agozzino, G. Caputo, Gaetano Salvatore, DI SOMMA, S, DI BENEDETTO, Mp, Salvatore, G, Agozzino, L, Ferranti, F, Esposito, S, LA DOGANA, P, Scarano, Mi, Caputo, G, Cotrufo, M, DE DIVITIIS, Oreste, Di Somma, S, Di Benedetto, Mp, La Dogana, P, DE SANTO, Luca Salvatore, and de Divitiis, O.
Subjects: Pathology, medicine.medical_treatment, Cardiomyopathy, heart failure, heart transplantation, cardiac, cardiomyopathy, complications/physiopathology, coronary angiography, cytology/metabolism/pathology, cytoskeleton, desmin, diagnosis/etiology/physiopathology, dilated, doppler, echocardiography, female, heart ventricles, humans, immunohistochemistry, ischaemic cardiomyopathy, male, metabolism, metabolism/pathology, microscopy, myocardial function, myocardial infarction, myocardium, myocardium cytology, myocytes, pathology/radiography/ultrasonography, physiology, polarization, severity of illness index, staining and labeling, stroke volume, treatment outcome, Myocytes, Cardiac, Myocardial infarction, Heart transplantation, Ejection fraction, Echocardiography, Doppler, Cardiology, Microscopy, Polarization, Cardiology and Cardiovascular Medicine, Cardiac function curve, Cardiomyopathy, Dilated, medicine.medical_specialty, Internal medicine, medicine, business.industry, medicine.disease, Heart failure, Myocardial infarction complications, Desmin, business
Abstract: Our aim was to evaluate the desmin content in the myocardial tissue of patients with end-stage heart failure of ischaemic origin and to assess its role on cardiac function. We studied 18 explanted hearts from patients transplanted for end-stage heart failure due to ischaemic cardiomyopathy (ICM). Control myocardial tissue was obtained from the cardiac biopsies of six women with breast cancer taken prior to commencing chemotherapy with anthracyclines, four male donors for heart transplantation and two autoptic hearts from patients who died due to non-cardiac events. Myocardial tissue, obtained from the left ventricle (remote zone from infarcted area), was analyzed by light and confocal immunochemistry (desmin) microscopy. The desmin content of myocardial tissue was obtained by real-time PCR. Cardiac function was evaluated by echocardiographic and right heart catheterization data, obtained before heart transplantation. Confocal microscopy evaluation showed a significant decrease in the number of desmin-positive myocytes (P
Published: 2003

22. Evolution of transsphenoidal surgery

Author: Paolo Cappabianca, O. de Divitiis, Francesco Maiuri, e Divitiis E., Cappabianca P., Cappabianca, Paolo, DE DIVITIIS, Oreste, and Maiuri, Francesco
Subjects: Transsphenoidal surgery, medicine.medical_specialty, Intracranial tumor, Pituitary disease, Endoscopic endonasal surgery, business.industry, medicine.medical_treatment, Functional endoscopic sinus surgery, medicine.disease, Transsphenoidal approach, Surgery, Pituitary adenoma, Medicine, Primary Brain Tumors, business
Abstract: The transsphenoidal route is the dominant approach to the pituitary and sellar area and is utilized for more than 95% of the surgical indications in this region. Pituitary adenomas represent the third most common primary intracranial tumor after gliomas and meningiomas, with a percentage of more than 15% in most series reported in the literature and are found in 20% of cases at routine autopsies for patients who do not die for pituitary disease. If we also consider the other lesions in this same area and the recently proposed extended transsphenoidal approaches [12, 24, 32, 33, 35, 36, 37, 40, 41, 43, 44, 48, 61], we should not be surprised by the figure reported by Jane Jr. et al. [30], indicating that 19% of primary brain tumors treated in academic centers in the United States are operated upon transsphenoidally.
Published: 2003

23. Extended endoscopic endonasal transphenoidal approaches to the suprasellar region, planum sphenoidale & clivus

Author: O. de Divitiis, Fabio Calbucci, E. Pasquini, Giorgio Frank, Paolo Cappabianca, DE DIVITIIS, CAPPABIANCA, Cappabianca, P., Frank, G., Pasquini, E., DE DIVITIIS, Oreste, and F. C. A. L. B. U. C. C. I.
Subjects: medicine.medical_specialty, medicine.anatomical_structure, Suprasellar region, Clivus, business.industry, Planum temporale, medicine, Radiology, business, Mucoperiosteal Flap, Transsphenoidal approach
Abstract: The standard unilateral endoscopic transsphenoidal approach has permitted a very wide vision around the sella, with the possibility of lreating lesions not confined to its strict limits. This possibility does not concern only anatomical studies [1, 2, 3, 4, 6] but dinical cases too, that have undergone surgery both within the suprasellar, and in the dival compartments, besides the parasellar area, that has already been treated above. Relevant series on these extended approach es by means of the endoscopic technique have not yet been presented in the main literature, but sporadic reports are now coming in and we will introduce the main guidelines of the procedure along with some illustrative cases.
Published: 2003

24. Right ventricular myocardial diastolic dysfunction in different kinds of cardiac hypertrophy: analysis by pulsed Doppler tissue imaging

Author: M, Galderisi, S, Severino, P, Caso, S, Cicala, A, Petrocelli, L, De Simone, N, Mininni, and O, de Divitiis
Subjects: Adult, Male, Hypertrophy, Right Ventricular, Heart Ventricles, Ventricular Dysfunction, Right, Cardiomyopathy, Hypertrophic, Middle Aged, Echocardiography, Doppler, Color, Predictive Value of Tests, Ultrasonography, Doppler, Pulsed, Heart Septum, Humans, Female, Hypertrophy, Left Ventricular, Blood Flow Velocity
Abstract: Right ventricular (RV) chamber involvement has been demonstrated in hypertrophic cardiomyopathy (HCM) as well as in hypertensive left ventricular hypertrophy (LVH) but little is known about RV myocardial dysfunction occurring in these two pathologies. The aim of this study was to compare Doppler tissue imaging (DTI) of the right ventricle in HCM and LVH in relation to DTI of the left ventricle and Doppler standard of the RV and left ventricular (LV) inflow.Thirty controls, 20 hypertensives with LVH, and 23 patients with HCM involving the interventricular septum underwent Doppler echocardiography and pulsed DTI of the LV lateral mitral annulus and the RV lateral tricuspid annulus.Patients with HCM had a higher blood pressure, septal thickness and LV mass in comparison with the other two groups. The RV wall thickness did not differ between HCM and LVH. The fractional shortening, but not the tricuspid annular plane excursion, was higher in HCM. After adjusting for the mean blood pressure, the Doppler-derived global LV and RV diastolic functions were more impaired in HCM than in LVH. Also the majority of DTI LV and RV diastolic measurements were altered more in HCM. At the RV tricuspid annulus, myocardial diastolic indexes were impaired in HCM and LVH in comparison with controls but the deceleration and relaxation times distinguished also HCM and LVH, being much longer in HCM (p0.0001). In the overall population, the RV myocardial relaxation time was positively related to the septal wall thickness and the RV wall thickness, even after adjusting for age, heart rate, diastolic blood pressure, fractional shortening and DTI mitral relaxation time.The impairment of RV myocardial relaxation is much more evident in HCM than in LVH, its degree being independently associated with the extent of both the septal and RV wall thickness. Pulsed DTI may be useful to distinguish the extent of RV myocardial dysfunction in different types of cardiac hypertrophy.
Published: 2002

25. endoscopic fenestration of symptomatic septum pellucidum cysts: three case reports with discussion on the approaches and technique

Author: E. de Divitiis, O. de Divitiis, Paolo Cappabianca, Francesco Maiuri, Michelangelo Gangemi, Concetta Alafaci, Francesco Tomasello, Gangemi, Michelangelo, Maiuri, F, Cappabianca, Paolo, Alafaci, C, DE DIVITIIS, Oreste, Tomasello, F, DE DIVITIIS, E., Maiuri, F., Alafaci, C., Tomasello, F., Gangemi, M., Maiuri, Francesco, de Divitiis, E., and Gangemi, M
Subjects: Adenoma, Adult, Male, Hemangioma, Cavernous, Central Nervous System, medicine.medical_specialty, Septum Pellucidum - Cyst - Endoscopy, medicine.medical_treatment, Angioma, Hemangioma, Lateral ventricles, Foramen, Humans, Medicine, Pituitary Neoplasms, Cyst, Child, Craniotomy, Septum pellucidum, medicine.diagnostic_test, Brain Neoplasms, Cysts, business.industry, Endoscopy, General Medicine, medicine.disease, Magnetic Resonance Imaging, Surgery, Treatment Outcome, Female, Septum Pellucidum, Neurology (clinical), business, Cerebral Ventricle Neoplasms
Abstract: Objectives We describe three patients with symptomatic septum pellucidum cysts treated by endoscopic fenestration and discuss the different endoscopic approaches to these cysts. Clinical presentation The patients are an 8-year-old boy, a 7-year-old boy and a 21-year-old woman; this last also had a right frontal cavernous angioma and a pituitary microadenoma. All patients presented with headache, associated with vomiting in two and behavioral changes in one. In all cases magnetic resonance showed a septum pellucidum cyst. Intervention Two patients were operated upon by posterior approach through a right occipital burr hole and underwent fenestration from the right occipital horn to the cyst, with a second fenestration from the cyst to the left lateral ventricle in one. Another patient underwent microsurgical removal of a right frontal cavernoma and endoscopic cyst fenestration with both lateral ventricles through a right frontal craniotomy. Postoperatively, headache and vomiting resolved in all cases and behaviour changes improved in one. Conclusions Endoscopic fenestration is the treatment of choice for septum pellucidum cysts, where it results in immediate relief of the mass effect of the cyst and in the remission of the associated symptoms. We suggest a posterior approach through a right occipital burr hole. It allows one to easily cannulate the occipital horn, which is usually larger than the frontal one, thus avoiding the risk of damaging the vascular and neural structures surrounding the foramen of Monro. Besides, the endoscopic trajectory is in our opinion more direct. The two-window technique, with fenestration of the cyst into both lateral ventricles, improves the chances of long-term patency.
Published: 2002

26. Right ventricular diastolic dysfunction in arterial systemic hypertension: analysis by pulsed tissue Doppler

Author: Maurizio Galderisi, O. de Divitiis, Pio Caso, S. Cicala, Raffaele Calabrò, A. Petrocelli, Arcangelo D'Errico, Cicala, S, Galderisi, Maurizio, Caso, P, Petrocelli, A, D'Errico, A, de Divitiis, O, Calabrò, R., Galderisi, M, DE DIVITIIS, O, and Calabro', Raffaele
Subjects: Adult, Male, medicine.medical_specialty, Systole, Heart Ventricles, Ventricular Dysfunction, Right, Population, Diastole, Doppler echocardiography, Heart Ventricle, Right ventricular hypertrophy, Internal medicine, Mitral valve, Medicine, Humans, Radiology, Nuclear Medicine and imaging, cardiovascular diseases, education, education.field_of_study, Tricuspid valve, medicine.diagnostic_test, business.industry, General Medicine, Middle Aged, medicine.disease, Echocardiography, Doppler, medicine.anatomical_structure, Ultrasonography, Doppler, Pulsed, Hypertension, cardiovascular system, Ventricular pressure, Cardiology, Ventricular Function, Right, Mitral Valve, Female, Tricuspid Valve, Cardiology and Cardiovascular Medicine, business, Human
Abstract: Aims: This study analyses right ventricular longitudinal function in arterial systemic hypertension by pulsed tissue Doppler. Methods and Results: Thirty normotensives and 30 hypertensives, free of cardiac drugs, underwent standard Doppler echocardiography and pulsed tissue Doppler of right ventricular lateral tricuspid annulus and left ventricular lateral mitral annulus. By tissue Doppler, systolic and diastolic measurements were obtained. Hypertensives had higher left ventricular mass and impaired Doppler diastolic indexes, without changes of global systolic function. Tissue Doppler showed reduction of right ventricular E/A ratio and prolongation of relaxation time in comparison with controls (both P
Published: 2002

27. Impact of myocardial diastolic dysfunction on coronary flow reserve in hypertensive patients with left ventricular hypertrophy

Author: M, Galderisi, S, Cicala, L, De Simone, P, Caso, A, Petrocelli, L, Pietropaolo, A, Celentano, N, Mininni, and O, de Divitiis
Subjects: Male, Dose-Response Relationship, Drug, Myocardium, Blood Pressure, Middle Aged, Echocardiography, Doppler, Color, Italy, Diastole, Heart Rate, Coronary Circulation, Dobutamine, Hypertension, Exercise Test, Ventricular Dysfunction, Humans, Female, Hypertrophy, Left Ventricular, Blood Flow Velocity
Abstract: The aim of the study was to assess the possible association, in hypertensive patients, between left ventricular myocardial diastolic dysfunction and coronary flow reserve (CFR) in relation to the presence of left ventricular hypertrophy (LVH).Twenty-eight untreated hypertensives (22 males, 6 females, mean age 53.1 years), free of coronary artery disease, were enrolled in the study. Standard Doppler echocardiography, color Doppler tissue imaging of the posterior septum during dobutamine stress and second harmonic Doppler of the distal left anterior descending coronary vessel, at baseline and after maximal hyperemia induced by dipyridamole, were performed. CFR was estimated as the ratio between hyperemic and baseline diastolic velocities. Hypertensives were divided into two groups according to the left ventricular mass index: 15 without LVH (left ventricular mass index51 g/m2.7) and 13 with LVH (left ventricular mass index51 g/m2.7). The two groups were comparable for sex prevalence, age, body mass index, baseline heart rate and blood pressure.Color Doppler tissue imaging did not show any significant difference of both the baseline and high-dobutamine septal systolic peak velocities between the two groups. The ratio between myocardial early and atrial peak velocities (Em/Am ratio) was lower in patients with LVH, either at baseline (p0.01) or at high-dose dobutamine (p0.0001). Also, CFR was lower in the presence of LVH (p0.01). After adjusting for age, body mass index, left ventricular mass index, diastolic blood pressure and high-dose dobutamine heart rate by a multiple linear regression analysis, the high-dose dobutamine Em/Am ratio was an independent contributor of CFR in the overall hypertensive population (beta = 0.65, p0.0001) (cumulative r2 = 0.38, p0.0001).The combined use of second harmonic Doppler and color Doppler tissue imaging identifies, in arterial hypertension, an association between myocardial diastolic properties and CFR, independent of the presence of LVH. In hypertensive patients free of coronary artery stenosis, left ventricular myocardial diastolic dysfunction may be a determinant in the impairment of the coronary microvessel vasodilation capacity or a marker of silent ischemia involving the microvascular circulation.
Published: 2001

28. Immunohistochemical TRF1 expression in human primary intracranial tumors

Author: M, Aragona, O, De Divitiis, D, La Torre, S, Panetta, D, D'Avella, A, Pontoriero, M, Morelli, I, La Torre, and F, Tomasello
Subjects: DNA-Binding Proteins, Ki-67 Antigen, Brain Neoplasms, Feasibility Studies, Humans, Telomeric Repeat Binding Protein 1, Meningioma, Immunohistochemistry
Abstract: The telomeric-repeat binding factor (TRF1) participates in a physiological homeostatic mechanism controlling telomere shortening by inhibiting telomerase activity: down-regulation of TRF1 expression results in telomere elongation and may be involved in cell immortalization.To determine the TRF1 expression by immunohistochemistry (IHC) in human brain tumors, a cohort of 20 consecutive flash-frozen surgical specimens (14 meningiomas and 6 anaplastic astrocytomas (AA)) were collected.Variable levels of TRF1 expression in 12 out of the 14 (87.5%) meningioma samples were observed. By contrast, no expression of TRF1 in tissue samples from AA (p = 0.008) was detected. Positive TRF1 cells were usually more differentiated (less atypical features) and Ki67 negative (inverse statistical association, chi2 = p0.001).We demonstrated, for the first time, that routine IHC techniques are capable of identifying TRF1 expression in intracranial tumors, which is heterogeneously expressed in meningiomas, but absent in AA. Although these preliminary observations need confirmation from larger studies, the TRF1 status in intracranial tumors might become of prognostic value.
Published: 2001

29. Inverse correlation of TRF1 expression and cell proliferation in human primary intracranial tumors

Author: O, De Divitiis and D, La Torre
Subjects: Brain Neoplasms, Astrocytoma, Telomere, Immunohistochemistry, Antibodies, Cohort Studies, DNA-Binding Proteins, Ki-67 Antigen, Biomarkers, Tumor, Humans, Telomeric Repeat Binding Protein 1, Meningioma, Telomerase, Cell Division
Abstract: The telomeric-repeat binding factor (TRF1) participates in a physiological homeostatic mechanism controlling cellular proliferative potential. TRF1 is involved in a negative feedback mechanism that allows telomere shortening by inhibiting the activity of telomerase. Down-regulation of TRF1 expression results in telomere elongation and may be involved in cell immortalization. The goal of the present study was to determine whether routine immunohistochemical (IHC) techniques can characterize TRF1 expression in different human brain tumor specimens and whether it correlates with other indices of brain tumor's proliferative potential.A cohort of 20 flash-frozen surgical specimens [14 meningiomas and 6 anaplastic astrocytomas (AA)] were evaluated for TRF1 expression. Results of parallel investigations of tumor's proliferative indices as assessed by Ki67 labeling index (LI) determinations were cross-correlated with TRF1 expression results and histotype.We demonstrated variable levels of TRF1 expression in 12 out of 14 (87.5%) meningioma samples. By contrast, we detected no expression of TRF1 in tissue samples from AA (p=0.008). The Ki67 LI was higher in AA than in meningioma samples (15.21+/-9.34 vs 26.6+/-13.89, p=0.044). Statistical analysis revealed a significant inverse correlation between TRF1 expression, histotype, and LI (c2=14.1; p=0.0008).We demonstrated for the first time that routine IHC techniques are capable to identifying TRF1 expression in intracranial tumors. The results suggest that TRF1 is heterogeneously expressed in meningiomas, and absent in AA. The TRF1 status in intracranial tumors might be of prognostic value and possibly represent a potential application for biologically targeted therapeutic strategies.
Published: 2001

30. [Venous thromboembolism. Introduction]

Author: O, de Divitiis
Subjects: Venous Thrombosis, Time Factors, Fibrinolytic Agents, Heparin, Thromboembolism, Anticoagulants, Humans, Ultrasonography, Doppler, Plethysmography, Impedance, Heparin, Low-Molecular-Weight, Thrombophlebitis, Pulmonary Embolism
Abstract: The main aim of the treatment of deep venous thrombosis (DVT) is to prevent the onset of the main complications: embolism (acute) and post-phlebothrombotic syndrome-PPS--(late complication). If not treated, during the acute phase DVT presents extension and/or embolism in 60% of cases and pulmonary embolism is potentially fatal in 5-10%. PPS is the most frequent complication (up to 70% of cases). The treatment of acute DVT has been based for over thirty years on heparin and oral anticoagulants: thrombolytic agents and low molecular weight (LMWH) heparins have been introduced more recently. Anticoagulants treatment is continued for 3-6 months (or longer in the event of recidivation or thrombophilia). LMWH have proved more effective and easier to manage than non-fractioned heparin. The association of thrombolytic and heparin presents no advantages compared to the use of heparin alone. It is currently reserved for cases of venous gangrene and acute massive pulmonary embolism. The possibility of surgical embolectomy or the use of catheters should only be considered in treatment is ineffective or contraindicated. The aim of this paper is to analyse the treatment of DVT and the diagnostic, clinical, laboratory and instrumental procedures used, and to describe the most up-to-date indications for its diagnosis and treatment.
Published: 2001

31. Changes in myocardial cytoskeletal intermediate filaments and myocyte contractile dysfunction in dilated cardiomyopathy: an in vivo study in humans

Author: Giovanni Cuda, S Di Somma, G Caputo, F. De Vivo, M P Di Benedetto, F Ciaramella, G. Cudemo, M Marotta, G Salvatore, O. De Divitiis, DI SOMMA, S., Marotta, Marcello, Salvatore, G., Cudemo, G., Cuda, G., DE VIVO, F., DI BENEDETTO, M. P., Ciaramella, F., Caputo, G., DE DIVITIIS, O., Di Somma, S., Marotta, M., DI BENEDETTO, M., Ciaramella, S., Caputo, Giuseppe, and DE DIVITIIS, O. .
Subjects: Adult, Cardiomyopathy, Dilated, Male, medicine.medical_specialty, Pathology, Biopsy, Cardiomyopathy, desmin, Vimentin, Radionuclide ventriculography, macromolecular substances, In Vitro Techniques, Myosins, Immunoenzyme Techniques, cardiac biopsy, vimentin, Intermediate Filament Proteins, Internal medicine, dilated cardiomyopathy, desmin, vimentin, cardiac biopsy, actin-myosin, actin-myosin, Humans, Medicine, Intermediate filament, Cytoskeleton, Aged, Ejection fraction, biology, business.industry, Myocardium, Dilated cardiomyopathy, Middle Aged, medicine.disease, Actins, dilated cardiomyopathy, Cytoskeletal Proteins, Basic Research, Heart failure, biology.protein, Cardiology, Female, Desmin, Cardiology and Cardiovascular Medicine, business
Abstract: AIM—To investigate in vivo the intermediate cytoskeletal filaments desmin and vimentin in myocardial tissues from patients with dilated cardiomyopathy, and to determine whether alterations in these proteins are associated with impaired contractility. METHODS—Endomyocardial biopsies were performed in 12 patients with dilated cardiomyopathy and in 12 controls (six women with breast cancer before anthracycline chemotherapy and six male donors for heart transplantation). Biopsy specimens were analysed by light microscopy and immunochemistry (desmin, vimentin). Myocyte contractile protein function was evaluated by the actin-myosin in vitro motility assay. Left ventricular ejection fraction was assessed by echocardiography and radionuclide ventriculography. RESULTS—Patients with dilated cardiomyopathy had a greater cardiomyocyte diameter than controls (p
Published: 2000

32. Plasma leptin level is associated with myocardial wall thickness in hypertensive insulin-resistant men

Author: Maurizio Galderisi, Guido Antonio Zito, Giuseppe Paolisso, O. de Divitiis, Maria Tagliamonte, A. Petrocelli, Michele Varricchio, Carlo Carella, Paolisso, G, Tagliamonte, M. R, Galderisi, Maurizio, Zito, G. A, Petrocelli, A, Carella, C, de Divitiis, O, Varricchio, M., Paolisso, Giuseppe, Tagliamonte, Mr, Galderisi, M, Zito, Ga, and DE DIVITIIS, O
Subjects: Adult, Leptin, Male, medicine.medical_specialty, medicine.medical_treatment, Left ventricular hypertrophy, Body Mass Index, Insulin resistance, Internal medicine, Hyperinsulinism, Blood plasma, Heart rate, Internal Medicine, medicine, Humans, business.industry, Insulin, Middle Aged, medicine.disease, Blood pressure, Endocrinology, Echocardiography, Hypertension, Hypertrophy, Left Ventricular, Insulin Resistance, business, Body mass index, Human
Abstract: Abstract —Leptin, the product of the ob gene, has been shown to increase heart rate and blood pressure through a stimulation of cardiac sympathetic nervous system activity, a phenomenon also involved in the pathogenesis of left ventricular hypertrophy in hypertensives. Thus, we hypothesize that plasma leptin concentration is associated with left ventricular hypertrophy. Forty hypertensive males and 15 healthy male subjects underwent anthropometric and echocardiographic evaluations, assessment of insulin sensitivity through euglycemic glucose clamp combined with indirect calorimetry, and determination of fasting plasma leptin concentration. Fasting plasma leptin levels were higher in hypertensives than in controls (6.48±2.9 versus 4.62±1.5 ng/mL, P P r =0.46, P r =0.50, P r =−0.27, P r =0.34, P r =0.38, P r =0.68, P + concentration, whole-body glucose disposal, and diastolic blood pressure explained 68% of the variability of the sum of wall thicknesses with fasting plasma leptin concentration ( P P P
Published: 1999

33. Provision of a neuroendoscopy service. The Southampton experience

Author: O, De Divitiis
Subjects: Adult, Aged, 80 and over, Endoscopes, Male, Reoperation, Brain Diseases, Adolescent, Brain Neoplasms, Infant, Newborn, Teratoma, Infant, Endoscopy, Middle Aged, Surgical Instruments, Magnetic Resonance Imaging, Pineal Gland, Cerebrospinal Fluid Shunts, Cerebral Ventricles, Postoperative Complications, Humans, Equipment Failure, Female, Child, Aged, Hydrocephalus
Abstract: A series of 21 patients (aged 1 week to 80 years) underwent a total of 22 neuroendoscopic procedures in our Unit in the period July 1993 to January 1996.The procedures were performed by one surgeon familiar with the technique using the Stortz rigid neuroendoscope system. The most common indication for neuroendoscopy was obstructive hydrocephalus. The most frequently performed procedure was third ventriculostomy and tumor biopsy. The intended surgical procedure was successfully performed in all but two of the cases (attempted septostomy and internal cyst drainage) were both abandoned due to unrecognisable anatomy.Of the 19 patients treated by fenestration or ventriculostomy to relieve hydrocephalus, 5 eventually required definitive shunting procedures.Complications relating directly to the neuroendoscopy occurred in 2 patients (bleeding requiring temporary external ventricular drain) and there were no surgical deaths.
Published: 1999

34. Anomalous meningeal branches of the ophthalmic artery feeding meningiomas of the brain convexity

Author: Francesco Maiuri, Francesco Briganti, O. de Divitiis, Mario Fusco, R. Donzelli, Maiuri, Francesco, Donzelli, Renato, DE DIVITIIS, Oreste, Fusco, M., Briganti, Francesco, F., Maiuri, R., Donzelli, M., Fusco, and F., Briganti
Subjects: Adult, Male, medicine.medical_specialty, Accessory meningeal artery, Middle meningeal artery, medicine.medical_treatment, Carotid angiography, Pathology and Forensic Medicine, Meningioma, Ophthalmic Artery, medicine.artery, medicine, Meningeal Neoplasms, Humans, Radiology, Nuclear Medicine and imaging, Embolization, business.industry, Maxillary artery, Anatomy, Middle Aged, medicine.disease, Meningeal Arteries, Cerebral Angiography, Close relationship, Ophthalmic artery, Surgery, Female, Radiology, business
Abstract: Many anomalies may involve the ophthalmic and middle meningeal arteries, because of the close relationship of their development. The system of the ophthalmic artery may supply the dural convexity by the middle meningeal artery of ophthalmic origin, the anterior branch of the middle meningeal artery or an accessory meningeal artery. The development and the anatomic arrangement of these anomalous vessels are discussed. Three cases of meningiomas of the brain convexity supplied by anomalous meningeal arteries arising from the ophthalmic artery are described. In one case internal carotid angiography showed an anomalous anterior branch of the middle meningeal artery arising from the ophthalmic artery, whereas the maxillary artery provided only the posterior branch of the middle meningeal artery. In two cases the middle meningeal artery system was normal, but the ophthalmic artery provided an accessory meningeal artery supplying the meningioma. Whereas an ophthalmic origin of the middle meningeal artery is rather common, the angiographic finding of an accessory meningeal artery or an anterior branch of the middle meningeal artery arising from the ophthalmic arterial system is exceptional. The preoperative embolization of dural lesions supplied by anomalous meningeal vessels of ophthalmic origin is dangerous because of the risk of embolization into the ophthalmic circle.
Published: 1998

35. [The influence of left systolic ventricular function on right ventricular function after an acute myocardial infarct]

Author: A, Izzo, M, Galderisi, and O, de Divitiis
Subjects: Male, Analysis of Variance, Electrocardiography, Systole, Linear Models, Myocardial Infarction, Ventricular Function, Right, Humans, Female, Clinical Enzyme Tests, Middle Aged, Echocardiography, Doppler, Ventricular Function, Left
Abstract: The aim of this study was to assess the interaction between left ventricular and right ventricular systolic function after acute myocardial infarction (AMI). The study population comprises 27 normal subjects and 71 patients assessed at predischarge (12 +/- 7 days) after AMI and divided into two subgroups, 24 with inferior AMI and 47 with non inferior AMI. The three groups were comparable for sex, age, heart rate and blood pressure. Right ventricular function was evaluated by two-dimensional assessment of tricuspid annular plane systolic excursion (TAPSE) and by Doppler analysis of right ventricular outflow tract. Left ventricular systolic function was evaluated by two-dimensional determination of ejection fraction and wall motion score index, and by Doppler analysis of left ventricular outflow tract. The overall AMI population showed reduced TAPSE, velocity-time integral (both p0.05) and peak velocity (p0.005) of right ventricular outflow tract, prolongation of Q-S2 interval and increase of pre-ejection period/acceleration time ratio (both p0.05) in comparison with normals. These alterations were accompanied by a decrease of left ventricular ejection fraction and increase of wall motion score index. (p0.0001) The changes of right ventricular indexes were confirmed in patients with inferior AMI who had also lower left ventricular ejection fraction (46 +/- 9%). Functional parameters of the right ventricle were not significantly modified in patients with non inferior AMI who had greater left ventricular ejection fraction (53 +/- 8.6%). In the overall AMI population, and in particular in inferior AMI, we found univariate relations between time-velocity integrals of left ventricular and right ventricular outflow tract and between left ventricular ejection fraction and TAPSE. Only in inferior AMI creatinkinase peak was related to time-velocity integral of right ventricular outflow tract (r = -0.59, p0.01). In conclusion, the magnitude of right ventricular systolic impairment developing after left ventricular AMI depends on the degree of left ventricular dysfunction, likewise by changes of hemodynamic load imposed to the right ventricle. AMI location and, only in inferior AMI, infarct extension participate in determining this dysfunction.
Published: 1998

36. The oculomotor nuclear complex in humans. Microanatomy and clinical significance

Author: O. de Divitiis, R. Donzelli, Francesco Maiuri, L. Brigante, Ivana Nikodijević, Slobodan Marinković, R., Donzelli, S., Marinkovic, L., Briganti, I., Nikodijevic, F., Maiuri, DE DIVITIIS, Oreste, Donzelli, Renato, Marinkovic, S., Brigante, L., Nikodijevic, I., and Maiuri, Francesco
Subjects: Adult, Oculomotor Nuclear Complex, genetic structures, Somatic cell, Neurologic Signs, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Oculomotor Nerve, Mesencephalon, Cadaver, Humans, Medicine, Clinical significance, Radiology, Nuclear Medicine and imaging, Interstitial nucleus, 030304 developmental biology, Motor Neurons, 0303 health sciences, business.industry, Oculomotor nerve, Edinger–Westphal nucleus, Anatomy, medicine.anatomical_structure, nervous system, Periaqueductal gray matter, Surgery, business, Nucleus, 030217 neurology & neurosurgery
Abstract: This study has been performed to define better the anatomical structure of the oculomotor nuclear complex and its neuronal components. The oculomotor nuclear complex was examined in fixed and serially sectioned midbrains from 12 adult subjects free from neurological diseases. The complex included the somatic portion, (formed by multipolar motor neurons), and the parasympathetic portion, (formed by oval or fusiform preganglionic cells), on each side of the median raphe. The somatic portion consisted of the lateral somatic cell column and the caudal central nucleus. The somatic column measured from 0.2 x 0.1 mm to 3.4 x 1.4 mm (X = 2.4 x 1.2 mm) in transverse section. It was divided into the principal, intrafascicular and extrafascicular parts. The principal part was subdivided into the dorsal, intermediate and ventral portions. Isolated multipolar neurons were also found in the periaqueductal gray matter, the interstitial nucleus of Cajal, the Edinger-Westphal nucleus and the fibre bundles of the oculomotor nerve. These cells most likely represent the displaced motor neurons of the oculomotor nerve. The caudal central nucleus was 0.8 x 0.6 mm in size. The Edinger-Westphal nucleus consisted of the rostral, ventral and dorsal parts; the longest rostrocaudal diameter of this nucleus measured 7.1 mm. The anatomical data of our study are relevant clinically and allow explanation of the neurologic signs following complete or partial lesions of the oculomotor nuclear complex.
Published: 1998

37. Neuropsychological outcome of operated cerebral aneurysms: prognostic factors on 148 patients

Author: Marcella Laiacona, A. De Santis, M.M. Migliore, O. de Divitiis, Riccardo Barbarotto, Erminio Capitani, DE SANTIS, A, Laiacona, M, Barbarotto, R, DE DIVITIIS, Oreste, Migliore, M, and Capitani, E.
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, Low education, Neuropsychological Tests, Central nervous system disease, Aneurysm, medicine, Humans, In patient, Aged, Retrospective Studies, Aged, 80 and over, Analysis of Variance, medicine.diagnostic_test, Vascular disease, business.industry, Neuropsychology, Age Factors, Intracranial Aneurysm, General Medicine, Neuropsychological test, Middle Aged, medicine.disease, Prognosis, Surgery, medicine.anatomical_structure, Neurology, Disease Progression, Educational Status, Female, Neurology (clinical), business, Cognition Disorders, Artery
Abstract: Objectives - To analyse prognostic factors in patients operated upon for cerebral aneurysms. A previous investigation by our group showed that patients operated later than 10 days after bleeding have a worse neuropsychological prognosis, but the number of patients operated upon within 3 days was not sufficient. Here, a new sample of patients with early surgery is included in the analyses. Material and methods - Patients numbered 148 (65 with ACoA, 39 with MCA, and 44 with PCoA aneurysms): 56 were operated within 3 days, 44 within 4-10 days, and 48 after at least 10 days from bleeding. A standardized battery of 13 neuropsychological tests was adopted: we considered both the number of defective scores and the average performance. Results - Patients operated later than 10 days after bleeding had a worse prognosis than the 2 groups with early and intermediate surgery, which were not different. Aneurysm site was not relevant. Old age and low education were associated with a worse prognosis. Hunt and Hess scores at operation and post operation were also predictivc of the outcome. Conclusion - On the whole, patients operated upon later than 10 days after bleeding have a less favourable prognosis than those with earlier operation timing.
Published: 1998

38. Territories of the perforating (lenticulostriate) branches of the middle cerebral artery

Author: Slobodan Marinković, Ivana Nikodijević, Francesco Maiuri, L. Brigante, O. de Divitiis, R. Donzelli, Claudio Schonauer, Donzelli, Renato, Marinkovic, S., Brigante, L., DE DIVITIIS, Oreste, Nikodijevic, I., Schonauer, C., and Maiuri, Francesco
Subjects: Adult, Male, Internal capsule, Caudate nucleus, 030218 nuclear medicine & medical imaging, Pathology and Forensic Medicine, 03 medical and health sciences, Anterolateral central arteries, 0302 clinical medicine, medicine.artery, Cadaver, medicine, Humans, Radiology, Nuclear Medicine and imaging, 030304 developmental biology, Aged, 0303 health sciences, Basal forebrain, business.industry, Putamen, Brain, Anatomy, Cerebral Arteries, Middle Aged, medicine.anatomical_structure, Globus pallidus, nervous system, Cerebral cortex, 030220 oncology & carcinogenesis, Middle cerebral artery, Female, Surgery, business, 030217 neurology & neurosurgery
Abstract: The territories of the central branches of the middle cerebral artery (MCA) were examined in 21 injected human brains. It was noted that these central arteries supplied: the caudate nucleus (dorsolateral half of the rostral part of its head; the entire caudal part of the head; the body and rostral portion of the tail in some cases), the putamen (dorsolateral part of its rostral portion, the remainder of the putamen, except the most caudal part occasionally), the globus pallidus (the entire lateral segment, except the ventrorostral and, sometimes, the most caudal part), the basal forebrain (lateral parts of the basal nucleus of Meynert and the nucleus of the diagonal band, as well as fiber bundles in this region), the internal capsule (dorsal and ventrocaudal part of the anterior limb, dorsal part of the genu, dorsal and ventrorostral part of the posterior limb), the corona radiata (a narrow strip close to the internal capsule) and the cerebral cortex (the caudal orbitofrontal cortex occasionally). The presented data may have certain neuroradiologic, neurologic and neurosurgical significance.
Published: 1998

39. The Neurosurgical Point of View on Spinal Cord Tumors

Author: Roberto Villani, O. de Divitiis, Villani, R, and DE DIVITIIS, Oreste
Subjects: medicine.medical_specialty, medicine.anatomical_structure, Radiological and Ultrasound Technology, business.industry, medicine, Radiology, Nuclear Medicine and imaging, Neurology (clinical), Neurosurgery, Anatomy, business, Spinal cord
Published: 1998

40. 1076 Determinants of impaired coronary flow reserve in patients with type 2 diabetes mellitus without epicardial coronary artery stenosis

Author: O. de Divitiis, Arcangelo D'Errico, Pasquale Innelli, Pasquale Guarini, L. A. Ferrara, Milena Sidiropulos, and M. Galderisi
Subjects: medicine.medical_specialty, business.industry, Epicardial coronary artery, Coronary arteriosclerosis, Type 2 Diabetes Mellitus, Coronary flow reserve, General Medicine, medicine.disease, Stenosis, Internal medicine, medicine, Cardiology, Radiology, Nuclear Medicine and imaging, In patient, Cardiology and Cardiovascular Medicine, business
Published: 2006
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41. Regional diastolic function in normotensive versus hypertensive subjects: comparison using Doppler myocardial imaging

Author: P, Caso, M, Galderisi, C, Cioppa, S, Severino, L, De Simone, A, Izzo, C, Liberato, O, de Divitiis, and N, Mininni
Subjects: Echocardiography, Doppler, Pulsed, Male, Analysis of Variance, Diastole, Heart Rate, Systole, Data Interpretation, Statistical, Hypertension, Humans, Ventricular Function, Blood Pressure, Middle Aged
Abstract: Pulsed Doppler myocardial imaging (DMI) is a new technique that makes it possible to obtain an on-line quantitative assessment of wall motion in different myocardial segments through sample-volume placement. Therefore, this tool is suitable for identifying changes in regional diastolic function in uncomplicated arterial hypertension. In this study, we examined standard Doppler-derived indexes of global left ventricular diastolic function and regional diastolic parameters obtained by pulse-wave DMI in a population of hypertensive patients, comparing them with the indexes found in a control group of normotensive subjects.Thirty-six patients with uncomplicated hypertension and 10 normotensive subjects (all males) underwent a complete Doppler echocardiographic examination and a pulsed DMI assessment of 4 different myocardial segments: basal and middle septum, basal and middle lateral wall.The 2 groups were comparable in age and heart rate, but body mass index, systolic and diastolic blood pressure and left ventricular mass index were higher in hypertensives. All of the transmitral diastolic measurements were impaired in hypertensives, without any difference in the Doppler indexes of global systolic function. While there were no changes in the regional systolic measurements, most of the DMI parameters for diastolic function changed significantly in all 4 of the segments examined, with a greater statistical difference at the basal and middle septum. We found a relationship between the number of segments involved in the diastolic dysfunction (ie with peak velocity E/A1) and the degree of impairment of the transmitral E/A ratio solely in the hypertensive population.DMI is a useful tool for distinguishing left ventricular diastolic function in hypertensive patients and it provides information about the extent and degree of diastolic impairment in different myocardial segments. The basal and middle septum present more evident diastolic alterations. Minor but significant changes can be identified at the basal and middle lateral walls. The higher the prevalence of the myocardial segments involved in diastolic dysfunction, the greater the impairment of the global diastolic function of the left ventricle will be.
Published: 1997

42. The Role of Intraoperative Sonography in Reducing Invasiveness During Surgery for Spinal Tumors

Author: Giorgio Iaconetta, Francesco Maiuri, O. de Divitiis, F., Maiuri, G., Iaconetta, DE DIVITIIS, Oreste, Maiuri, Francesco, and Iaconetta, Giorgio
Subjects: Adult, Male, medicine.medical_specialty, Cord, Adolescent, medicine.medical_treatment, surgery/ultrasonography, methods, law.invention, Intramedullary rod, Central nervous system disease, Intraoperative Period, law, Minimally Invasive, medicine, Humans, Minimally Invasive Surgical Procedures, Neoplasm Invasiveness, Spinal Cord Neoplasms, Preschool, Child, Aged, Ultrasonography, Surgical Procedures, Spinal Neoplasms, business.industry, Adolescent, Adult, Aged, Child, Child, Preschool, Female, Humans, Intraoperative Period, Laminectomy, methods, Male, Middle Aged, Neoplasm Invasiveness, Spinal Cord Neoplasms, surgery/ultrasonography, Spinal Neoplasms, surgery/ultrasonography, Surgical Procedures, methods, Syringomyelia, ultrasonography, Treatment Outcome, Ultrasound, Laminectomy, General Medicine, Middle Aged, medicine.disease, Spinal cord, Spinal surgery, Syringomyelia, Surgery, medicine.anatomical_structure, Treatment Outcome, Child, Preschool, Female, Neurology (clinical), business, Bone structure
Abstract: The authors describe the ultrasound-guided surgical approach to 20 spinal tumors (13 extramedullary and 7 intramedullary). Intraoperative sonography (IOS) is important to reduce the extent of the laminectomy and dural opening, thus avoiding useless removal of bone structures. In cases of intramedullary tumors, IOS defines the extent of the posterior myelotomy, the presence of syringomyelic cavities caudal and/or cranial to the tumor and the deep extension of the tumor to the anterior cord surface. For these reasons, the routine use of IOS during surgery for spinal tumors reduces the surgical invasivity of this approach. The advantages and limits of the ultrasound-guided spinal surgery and the operative ultrasonographic findings of different spinal neoplasms are discussed.
Published: 1997

43. Functional MRI: primary motor cortex localization in patients with brain tumors

Author: A. Prinster, O. de Divitiis, Roberto Villani, Andrea Righini, Ildebrando Appollonio, Paola Scifo, Ferruccio Fazio, Diego Spagnoli, Lorenzo Bello, Giustino Tomei, M. Leonardi, Righini, A, de Divitiis, O, Prinster, A, Spagnoli, D, Appollonio, I, Bello, L, Scifo, P, Tomei, G, Villani, R, Fazio, F, and Leonardi, M
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, Movement, Brain Neoplasm, Central nervous system disease, Cortex (anatomy), Parietal Lobe, medicine, Humans, Radiology, Nuclear Medicine and imaging, In patient, Aged, MED/26 - NEUROLOGIA, medicine.diagnostic_test, business.industry, Brain Neoplasms, MED/37 - NEURORADIOLOGIA, Motor Cortex, Precentral gyrus, Magnetic resonance imaging, Anatomy, MED/27 - NEUROCHIRURGIA, Middle Aged, medicine.disease, Hand, Magnetic Resonance Imaging, Surgery, Frontal Lobe, medicine.anatomical_structure, Upper limb, Female, MED/09 - MEDICINA INTERNA, Primary motor cortex, business, Human, Motor cortex
Abstract: Purpose : Our goal was (a) to test the ability of functional MRI (fMRI) to localize the hand primary motor cortex in patients with brain neoplasms using a conventional scanner and (b) to compare within the same subject the location and morphology of the activated motor areas in the affected hemisphere with the contralateral ones. Method : Seventeen right-handed patients with frontoparietal intra- and extraaxial tumors were studied. Hand motor performance ranged from normal to slight impairment of finger dexterity. The fMRI study was based on a series of FLASH images. Two or three contiguous slices parallel to the bicommissural plane were acquired through the level of frontoparietal cortex. Each patient was requested to perform with each hand a finger-tapping task or a simpler repetitive flexion-extension of the last four fingers. Pseudo-color activation maps were then calculated by a Z-score method and superimposed on high resolution images. Results : Five patients were excluded because of gross motion artifacts. In all other patients, areas of significant signal increase were detected on the precentral gyrus. They had a spot-like appearance, and no substantial side-to-side differences in shape or extension could be observed. In the presence of severe compression of the gyri, a displacement of the activated areas in the affected hemisphere with respect to the contralateral ones was noticeable. Conclusion : fMRI localization of the primary motor area using a conventional scanner can be obtained also in patients with brain tumors, although with a lower success rate than in normal volunteer studies, mainly because of subject compliance problems. Areas of significantly increased signal are detectable even in cortex where normal anatomical patterns are lost.
Published: 1996

44. [Absence of an association of the D allele of the ACE gene with arterial pressure in mild-moderate essential arterial hypertension]

Author: A, Celentano, F P, Mancini, M, Crivaro, V, Palmieri, P, Tammaro, V, De Stefano, M, Oliviero, N, Di Palma Esposito, I, Pietropaolo, A, Tufano, G, Di Minno, O, de Divitiis, Celentano, A, Mancini, Fp, Crivaro, M, Palmieri, V, Tammaro, P, De Stefano, V, Oliviero, M, Di Palma Esposito, N, Pietropaolo, I, Tufano, A, DI MINNO, Giovanni, and de Divitiis, O.
Subjects: Adult, Male, Polymorphism, Genetic, Genotype, Hypertension, Humans, Blood Pressure, Female, Blood Pressure Monitoring, Ambulatory, Middle Aged, Peptidyl-Dipeptidase A, Alleles, Aged
Abstract: To assess the relationship between the angiotensin converting enzyme (ACE) gene I/D polymorphism, blood pressure (BP) and family history of hypertension, 133 hypertensive subjects (mean age 50 +/- 9 years, 78 males, 55 females) were selected according to both casual supine BP140/90 mmHg and ambulatory BP134/88 mmHg. Drug treatment was discontinued 2 weeks before entering the study. Subjects with myocardial ischemia, as well as those with "white coat" hypertension, were excluded. The study population was subclassified according to ageor = 50 years. Polymerase chain reaction was used to detect the I/D polymorphism of the ACE gene, and the DD genotype was analysed twice. The frequencies of the I and D allele were 42 and 58%, and the distribution of the ID+ II and DD genotypes were 69 and 31% respectively. No significant relation was found among ACE genotypes (DD vs ID+ II) and casual systolic or diastolic BP as well as ambulatory BP, both in the whole study population and in the subpopulation50 years old. No difference was found also in the distribution of dippers and no dippers, as well as in the distribution of subjects with a positive family history in the whole sample and hypertensives50 years old.
Published: 1996

45. Anti-hypertensive effect of manidipine: 24 hours monitoring evaluation and Doppler-echocardiographic remarks

Author: A, Celentano, M, Crivaro, F, Perticone, V, Palmieri, M, Oliviero, P, Tammaro, I, Pietropaolo, N, Di Palma Esposito, C, Cloro, C, Cosco, P L, Mattioli, and O, De Divitiis
Subjects: Adult, Male, Dihydropyridines, Blood Pressure, Ultrasonography, Doppler, Blood Pressure Monitoring, Ambulatory, Middle Aged, Calcium Channel Blockers, Piperazines, Hypertension, Humans, Female, Nitrobenzenes, Aged
Abstract: In order to evaluate the antihypertensive effects of manidipine, at the dosage of 10 or 20 mg once daily, we studied 36 patients (12 males and 24 females, mean age 54.3 years) with mild hypertension. After a wash-out period of 2 weeks and another 2 week run-in period with placebo, all the patients were assigned to a treatment with manidipine 10 mg/ day. After 2 weeks of treatment, the non-normalized (diastolic BP90 mmHg) and the non-responders (BP fall10 mmHg) received an increase in dosage to 20 mg/day. The drug effects were assessed by casual blood pressure (BP) measurement at baseline and after 4, 8, 12, 24, 36 and 52 weeks. At baseline and after 1 year of treatment a 24-h BP monitoring and a Doppler echocardiogram were performed. Routine laboratory tests were performed at baseline, after 6 months and after 1 year of treatment. At the end of the observation period, both casual systolic (p0.01) and diastolic (p0.001) BP were significantly reduced; 24-h BP monitoring showed a significant decrease in systolic (p0.05) and diastolic (p0.01) pressure, systolic and diastolic (p0.001) daytime and night-time measurements. The peak to through ratio was 67%. No difference was found in heart rate. Reduced interventricular septum thickness (p0.05), increased fractional shortening (p0.02), reduced end-systolic stress (p0.005) and systemic vascular resistances (p0.001), and lower values of atrial filling fraction (AFF) (p0.001) after 1 year of treatment have been shown at the Doppler-Echo evaluation. A multilinear regression analysis showed a relation between delta %AFF and delta %24-h systolic BP (R = 0.74; F = 7.5: p0.05) and with delta % daytime systolic BP (R = 0.77; F = 9.2; p0.02). No abnormal changes were observed in laboratory tests. Three non-responder patients and three patients with adverse effects (1 flushing and 2 ankle oedema) dropped out and were excluded from the final analysis. In conclusion, manidipine at an individualized dose of 10 or 20 mg. was effective and safe in the management of arterial hypertension. Hemodynamic evaluations after 1 year of treatment confirmed an improvement of systolic and diastolic function, with an evident reduction of afterload.
Published: 1996

46. Localization of Primary Motor Cortex in Patients with Frontal-parietal Neoplasms: an fMRI Study

Author: A. Prinster, Roberto Villani, Paola Scifo, Diego Spagnoli, Giustino Tomei, M. Leonardi, Ildebrando Appollonio, Lorenzo Bello, O. de Divitiis, Ferruccio Fazio, and Andrea Righini
Subjects: medicine.diagnostic_test, business.industry, Blood oxygenation level dependent, medicine, Precentral gyrus, Magnetic resonance imaging, In patient, Primary motor cortex, Functional magnetic resonance imaging, business, Neuroscience, Signal, Microcirculation
Abstract: Functional magnetic resonance imaging (fMRI), which uses BOLD (blood oxygenation level dependent contrast) technique, allows the identification of physiologically activated brain areas by means of a local and transient magnetic resonance (MR) signal increase [l]. The physical and physiological bases of the observed signal changes are not totally understood. The most accepted theory associates a local decrease in deoxyhemoglobin concentration within the venous microcirculation with the MR signal increase detected during brain activation [2].
Published: 1996
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47. ALTERED HEMODYNAMIC RESONSE TO A SALT AND VOLUME LOAD IN HYPERTENSIVE PATIENTS WITH DIASTOLIC DYSFUNCTION

Author: L DʼElia, Antonio Barbato, Maurizio Galderisi, O. de Divitiis, Roberto Boero, Ferruccio Galletti, Pasquale Strazzullo, and I. Ferrara
Subjects: Volume load, medicine.medical_specialty, Physiology, business.industry, Internal medicine, Internal Medicine, Cardiology, medicine, Diastole, Hemodynamics, Cardiology and Cardiovascular Medicine, business
Published: 2004
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48. [Atrial filling fraction predicts left ventricular systolic function after myocardial infarction: pre-discharge echocardiographic evaluation]

Author: M, Galderisi, A, Fakher, A, Petrocelli, A, Alfieri, M, Garofalo, and O, de Divitiis
Subjects: Male, Predictive Value of Tests, Systole, Case-Control Studies, Linear Models, Myocardial Infarction, Humans, Female, Atrial Function, Right, Middle Aged, Echocardiography, Doppler, Patient Discharge, Ventricular Function, Left
Abstract: Aim of the study was to examine the relation between Doppler-derived indices of left ventricular diastolic and systolic function early after myocardial infarction. Fifty-three patients (31 males, 22 females) recovering from acute myocardial infarction underwent predischarge Doppler echocardiographic examination. Patients with age70 years, previous myocardial infarction, more than mild mitral and aortic regurgitation, mitral and aortic stenosis were excluded. Twenty-two healthy subjects (13 males; 9 females) free of coronary risk factors were selected as the control group. Both end-diastolic and end-systolic volumes and ejection fraction were measured by two-dimensional echocardiography. Pulsed Doppler was used to evaluate mitral inflow and left ventricular outflow velocity patterns. The following indices were measured: peak velocity of early (E) and late (A) flows, ratio of E/A peak velocities, ratio of early to late time velocity integrals, atrial filling fraction (time velocity integral A / time velocity integral of flow during total diastole) and deceleration time of E wave for mitral inflow; peak and time-velocity integral for left ventricular outflow. Stroke volume and cardiac output were obtained by pulsed Doppler using the left ventricular outflow method. The two groups were comparable for age, with blood pressure (p0.05) and heart rate (p0.01) reduced in myocardial infarction patients. Both end-diastolic and end-systolic volumes were significantly higher (both p0.0001) and ejection fraction (p0.0001) lower after myocardial infarction. Also stroke volume and cardiac output (both p0.0001) were reduced in myocardial infarction patients. No significant difference in Doppler indices of diastolic function was observed between the two groups, except for shortened deceleration time (p0.0001) in myocardial infarction patients. Multilinear regression analyses were performed separately into the two groups to identify determinants of left ventricular systolic function. After adjusting for age, heart rate, systolic blood pressure and both end-diastolic and end-systolic volumes, atrial filling fraction was an independent predictor of stroke volume, with a direct relation (beta coefficient = 0.53, p0.001), in myocardial infarction patients but not in health subjects. In conclusion, our study confirms the pseudonormalization of diastolic pattern after myocardial infarction. The direct relation between atrial filling fraction and stroke volume indicates the importance of atrial contribution to maintain an adequate systolic performance in patients with myocardial infarction.
Published: 1995

49. Comparative evaluation of the antihypertensive efficacy of once-daily sustained-release isradipine and lacidipine using 24-hour ambulatory blood-pressure monitoring

Author: M. Garofalo, Maurizio Galderisi, O. de Divitiis, A Alfieri, Aldo Celentano, A. Petrocelli, Galderisi, Maurizio, Petrocelli, A, Garofalo, M, Celentano, Aldo, Alfieri, A, and de Divitiis, O.
Subjects: Male, Dihydropyridines, Ambulatory blood pressure, Diastole, Blood Pressure, 030204 cardiovascular system & hematology, Placebo, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Dihydropyridine, Heart Rate, Heart rate, Delayed-Action Preparation, medicine, Humans, Single-Blind Method, Antihypertensive Agents, Isradipine, Cross-Over Studies, business.industry, Biochemistry (medical), Cell Biology, General Medicine, Cross-Over Studie, Middle Aged, Antihypertensive Agent, Blood pressure, Lacidipine, 030220 oncology & carcinogenesis, Anesthesia, Delayed-Action Preparations, Ambulatory, Hypertension, Female, business, medicine.drug, Human
Abstract: In this single-blind crossover study the antihypertensive efficacies of two dihydropyridine calcium antagonists, sustained-release isradipine and lacidipine, were compared using clinic and ambulatory blood-pressure measurements. After a 2-week placebo wash-out, 34 patients (19 men, 15 women, mean age 49 years) with mild to moderate hypertension (diastolic blood pressure range 95 – 110 mmHg) were treated with 5 mg sustained-release isradipine for 4 weeks and 4 mg lacidipine for 4 weeks in a random order. Medications were taken once daily at 08.00 h. Clinic and ambulatory blood pressures were recorded at the end of each placebo or treatment period. Two patients stopped isradipine and six lacidipine because of severe adverse effects. Clinic systolic and diastolic blood pressures decreased by an average of 17/14 mmHg with isradipine and 17/13 mmHg with lacidipine, compared with placebo ( P < 0.01 in both cases), without a change in heart rate. Mean ambulatory 24-h and daytime systolic and diastolic blood pressure were significantly reduced by sustained-release isradipine and lacidipine ( P < 0.05 and P < 0.01, respectively). At night systolic blood pressure fell compared with placebo ( P < 0.05 with both drugs) whereas the reduction in diastolic blood pressure was not statistically significant. Mean 24-h heart rate remained unchanged. Blood-pressure variability did not differ significantly between the two drugs or between either drug and the placebo. The antihypertensive effects of sustained-release isradipine and lacidipine were similar, but the tolerability of isradipine appears to be greater since it caused fewer withdrawals.
Published: 1995

50. [The SINTESI Project: software in cardiovascular prevention]

Author: A, Celentano, V, Palmieri, P, Tammaro, M, Crivaro, M, Oliviero, I, Pietropaolo, V, Pasquarelli, A, Gaddi, and O, de Divitiis
Subjects: Adult, Male, User-Computer Interface, Databases, Factual, Italy, Cardiovascular Diseases, Risk Factors, Humans, Female, Software
Abstract: Coronary heart disease is the most important cause of mortality in adults. New approaches may reduce the cardiovascular risk in population. "SINTESI" is an original data base designed in collaboration with the Italian Group for the Study of Metabolism Disease and Atherosclerosis to improve the evaluation of the major risk factors in the population and to create a data bank for medical research. It runs in Windows. The software includes the following electronics archives: Demographics; History; Follow-up; ECG; Laboratory; Doppler-echocardiography; Stress test-ECT; Ambulatory blood pressure monitoring; Holter-ECG; Nuclear imaging; Vascular echo-Doppler; Hemodynamics; Radiology. We named the most important file "Main Working Area" (MWA). This displays all the most important information on the clinical status of the patients and represents the "console" for using the software. In fact, in MWA "buttons" are displayed to enter all the electronic archives. The software displays graphics and the flow-chart of clinical history. We implemented "routines" for automatic evaluation of several variables. We also simplify the statistical use of the data implementing functions for "query" that permit the management of data bank. The use of this software may facilitate the correct evaluation and stratification of the cardiovascular risk. In conclusion, "Progetto SINTESI" is an easy, synthetic organization of patient's clinical data and a complete data bank. It is our opinion that the use of this software may promote a standard way of collecting a large number of data to improve the stratification of cardiovascular risk.
Published: 1995

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