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2,703 results on '"Nishimura, Takashi"'

1. A characterization of the Legendre involution on the class of generic frontals

Author

Nishimura, Takashi

Subjects
Mathematics - Differential Geometry, 57R45, 58C25
Abstract

We show that, under an additional mild assumption, on the class of generic frontals, any involution whose fixed point set is exactly the same as the fixed point set of the Legendre involution must be the Legendre involution (Theorem 2 in \S 1). Moreover, its natural complexification (Corollary 1 in \S 3) is simultaneously shown., Comment: 9 pages, no figures

Published
2024

2. Adverse Events as Potential Predictive Factors of Activity in Patients with Advanced HCC Treated with Atezolizumab Plus Bevacizumab

Author

Persano, Mara, Rimini, Margherita, Tada, Toshifumi, Suda, Goki, Shimose, Shigeo, Kudo, Masatoshi, Rossari, Federico, Yoo, Changhoon, Cheon, Jaekyung, Finkelmeier, Fabian, Lim, Ho Yeong, Presa, José, Masi, Gianluca, Bergamo, Francesca, Amadeo, Elisabeth, Vitiello, Francesco, Kumada, Takashi, Sakamoto, Naoya, Iwamoto, Hideki, Aoki, Tomoko, Chon, Hong Jae, Himmelsbach, Vera, Iavarone, Massimo Alberto, Cabibbo, Giuseppe, Montes, Margarida, Foschi, Francesco Giuseppe, Vivaldi, Caterina, Soldà, Caterina, Sho, Takuya, Niizeki, Takashi, Nishida, Naoshi, Steup, Christoph, Bruccoleri, Mariangela, Hirooka, Masashi, Kariyama, Kazuya, Tani, Joji, Atsukawa, Masanori, Takaguchi, Koichi, Itobayashi, Ei, Fukunishi, Shinya, Tsuji, Kunihiko, Ishikawa, Toru, Tajiri, Kazuto, Ochi, Hironori, Yasuda, Satoshi, Toyoda, Hidenori, Ogawa, Chikara, Nishimura, Takashi, Hatanaka, Takeshi, Kakizaki, Satoru, Shimada, Noritomo, Kawata, Kazuhito, Hiraoka, Atsushi, Tada, Fujimasa, Ohama, Hideko, Nouso, Kazuhiro, Morishita, Asahiro, Tsutsui, Akemi, Nagano, Takuya, Itokawa, Norio, Okubo, Tomomi, Imai, Michitaka, Kosaka, Hisashi, Naganuma, Atsushi, Koizumi, Yohei, Nakamura, Shinichiro, Kaibori, Masaki, Iijima, Hiroko, Hiasa, Yoichi, Foti, Silvia, Camera, Silvia, Piscaglia, Fabio, Scartozzi, Mario, Cascinu, Stefano, and Casadei-Gardini, Andrea

Published
2024
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3. Quantitative measurements of M2BPGi depend on liver fibrosis and inflammation

Author

Uojima, Haruki, Yamasaki, Kazumi, Sugiyama, Masaya, Kage, Masayoshi, Ishii, Norihiro, Shirabe, Ken, Hidaka, Hisashi, Kusano, Chika, Murakawa, Miyako, Asahina, Yasuhiro, Nishimura, Takashi, Iijima, Hiroko, Sakamoto, Kazumasa, Ito, Kiyoaki, Amano, Keisuke, Kawaguchi, Takumi, Tamaki, Nobuharu, Kurosaki, Masayuki, Suzuki, Takanori, Matsuura, Kentaro, Taketomi, Akinobu, Joshita, Satoru, Umemura, Takeji, Nishina, Sohji, Hino, Keisuke, Toyoda, Hidenori, Yatsuhashi, Hiroshi, and Mizokami, Masashi

Published
2024
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4. On envelopes of circle families in the plane

Author

Wang, Yongqiao and Nishimura, Takashi

Subjects
Mathematics - Differential Geometry
Abstract

In this paper we investigate the relationships between envelopes of circle families and some special curves in the plane, such as evolutes, pedals, evolutoids and pedaloids.

Published
2023

5. Envelopes of straight line families in the plane

Author

Nishimura, Takashi

Subjects
Mathematics - Differential Geometry, 57R45, 58C25
Abstract

There is a widespread method to represent the envelope when a given hyperplane family creates an envelope. However, one sometimes encounters cases when the widespread method fails to represent the desired envelope precisely, and is confused. At the same time, one wants to find a correct method to draw the envelope precisely. In this article, focused on straight line families in the plane, an easy to understand explanation is given on the recently discovered correct method to represent the envelope precisely. Moreover, it is explained when and why the widespread method fails to represent the precise shape of envelope as well., Comment: Slightly modified version. To appear in Hokkaido Mathematical Journal

Published
2023

8. Envelopes created by circle families in the plane

Author

Wang, Yongqiao and Nishimura, Takashi

Subjects
Mathematics - Differential Geometry, 57R45, 58C25
Abstract

In this paper, on envelopes created by circle families in the plane, all four basic problems (existence problem, representation problem, problem on the number of envelopes, problem on relationships of definitions) are solved., Comment: some minor mistakes revisd

Published
2023

10. Safety and Efficacy of Lenvatinib in Very Old Patients with Unresectable Hepatocellular Carcinoma

Author

Camera, Silvia, Rimini, Margherita, Rossari, Federico, Tada, Toshifumi, Suda, Goki, Shimose, Shigeo, Kudo, Masatoshi, Yoo, Changhoon, Cheon, Jaekyung, Finkelmeier, Fabian, Lim, Ho Yeong, Presa, José, Masi, Gianluca, Bergamo, Francesca, Salani, Francesca, Marseglia, Mariarosaria, Amadeo, Elisabeth, Vitiello, Francesco, Kumada, Takashi, Sakamoto, Naoya, Iwamoto, Hideki, Aoki, Tomoko, Chon, Hong Jae, Himmelsbach, Vera, Iavarone, Massimo, Cabibbo, Giuseppe, Montes, Margarida, Foschi, Francesco Giuseppe, Vivaldi, Caterina, Lonardi, Sara, Sho, Takuya, Niizeki, Takashi, Nishida, Naoshi, Steup, Christoph, Hirooka, Masashi, Kariyama, Kazuya, Tani, Joji, Atsukawa, Masanori, Takaguchi, Koichi, Itobayashi, Ei, Fukunishi, Shinya, Tsuji, Kunihiko, Ishikawa, Toru, Tajiri, Kazuto, Ochi, Hironori, Yasuda, Satoshi, Toyoda, Hidenori, Ogawa, Chikara, Nishimura, Takashi, Hatanaka, Takeshi, Kakizaki, Satoru, Shimada, Noritomo, Kawata, Kazuhito, Hiraoka, Atsushi, Tada, Fujimasa, Ohama, Hideko, Nouso, Kazuhiro, Morishita, Asahiro, Tsutsui, Akemi, Nagano, Takuya, Itokawa, Norio, Okubo, Tomomi, Imai, Michitaka, Kosaka, Hisashi, Naganuma, Atsushi, Koizumi, Yohei, Nakamura, Shinichiro, Kaibori, Masaki, Iijima, Hiroko, Hiasa, Yoichi, Persano, Mara, Foti, Silvia, Piscaglia, Fabio, Scartozzi, Mario, Cascinu, Stefano, and Casadei-Gardini, Andrea

Published
2024
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11. New chemiluminescent enzyme immunoassay for quantitative measurement of Mac-2 binding protein glycosylation isomer in chronic liver disease

Author

Uojima, Haruki, Nakabayashi, Kadzuki, Yamasaki, Kazumi, Sugiyama, Masaya, Ishii, Norihiro, Shirabe, Ken, Kyoutou, Takuya, Ueda, Koji, Takahama, Yoichi, Tamaki, Nobuharu, Kurosaki, Masayuki, Hidaka, Hisashi, Kusano, Chika, Amano, Keisuke, Kawaguchi, Takumi, Taketomi, Akinobu, Joshita, Satoru, Umemura, Takeji, Murakawa, Miyako, Asahina, Yasuhiro, Suzuki, Takanori, Matsuura, Kentaro, Nishimura, Takashi, Iijima, Hiroko, Sakamoto, Kazumasa, Ito, Kiyoaki, Nishina, Sohji, Hino, Keisuke, Toyoda, Hidenori, Yatsuhashi, Hiroshi, Kage, Masayoshi, and Mizokami, Masashi

Published
2023
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14. Efficacy and safety of atezolizumab plus bevacizumab treatment for unresectable hepatocellular carcinoma patients with esophageal–gastric varices

Author

Tada, Fujimasa, Hiraoka, Atsushi, Tada, Toshifumi, Hirooka, Masashi, Kariyama, Kazuya, Tani, Joji, Atsukawa, Masanori, Takaguchi, Koichi, Itobayashi, Ei, Fukunishi, Shinya, Tsuji, Kunihiko, Ishikawa, Toru, Tajiri, Kazuto, Ochi, Hironori, Toyoda, Hidenori, Ogawa, Chikara, Nishimura, Takashi, Hatanaka, Takeshi, Kakizaki, Satoru, Shimada, Noritomo, Kawata, Kazuhito, Naganuma, Atsushi, Kosaka, Hisashi, Matono, Tomomitsu, Kuroda, Hidekatsu, Yata, Yutaka, Ohama, Hideko, Nouso, Kazuhiro, Morishita, Asahiro, Tsutsui, Akemi, Nagano, Takuya, Itokawa, Norio, Okubo, Tomomi, Arai, Taeang, Yokohama, Keisuke, Nishikawa, Hiroki, Imai, Michitaka, Koizumi, Yohei, Nakamura, Shinichiro, Iijima, Hiroko, Kaibori, Masaki, Hiasa, Yoichi, and Kumada, Takashi

Published
2023
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15. Current Use and Impact of Pulmonary Artery Catheters on the Short-Term Outcomes in Patients With Cardiogenic Shock Treated With an Impella: Findings From the Japan Registry for Percutaneous Ventricular Assist Device (J-PVAD)

Author

Arai, Riku, Murata, Nobuhiro, Fukamachi, Daisuke, Okumura, Yasuo, Ako, Junya, Ono, Minoru, Kinugawa, Koichiro, Kobayashi, Yoshio, Sato, Naoki, Sawa, Yoshiki, Shiose, Akira, Shindo, Takahiro, Toda, Koichi, Nishimura, Takashi, and Takayama, Morimasa

Published
2024
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18. Survival outcomes from atezolizumab plus bevacizumab versus Lenvatinib in Child Pugh B unresectable hepatocellular carcinoma patients

Author

Rimini, Margherita, Persano, Mara, Tada, Toshifumi, Suda, Goki, Shimose, Shigeo, Kudo, Masatoshi, Cheon, Jaekyung, Finkelmeier, Fabian, Lim, Ho Yeong, Presa, José, Salani, Francesca, Lonardi, Sara, Piscaglia, Fabio, Kumada, Takashi, Sakamoto, Naoya, Iwamoto, Hideki, Aoki, Tomoko, Chon, Hong Jae, Himmelsbach, Vera, Schirripa, Marta, Montes, Margarida, Vivaldi, Caterina, Soldà, Caterina, Hiraoka, Atsushi, Sho, Takuya, Niizeki, Takashi, Nishida, Naoshi, Steup, Christoph, Hirooka, Masashi, Kariyama, Kazuya, Tani, Joji, Atsukawa, Masanori, Takaguchi, Koichi, Itobayashi, Ei, Fukunishi, Shinya, Tsuji, Kunihiko, Ishikawa, Toru, Tajiri, Kazuto, Ochi, Hironori, Yasuda, Satoshi, Toyoda, Hidenori, Ogawa, Chikara, Nishimura, Takashi, Hatanaka, Takeshi, Kakizaki, Satoru, Shimada, Noritomo, Kawata, Kazuhito, Tada, Fujimasa, Ohama, Hideko, Nouso, Kazuhiro, Morishita, Asahiro, Tsutsui, Akemi, Nagano, Takuya, Itokawa, Norio, Okubo, Tomomi, Arai, Taeang, Imai, Michitaka, Kosaka, Hisashi, Naganuma, Atsushi, Koizumi, Yohei, Nakamura, Shinichiro, Kaibori, Masaki, Iijima, Hiroko, Hiasa, Yoichi, Burgio, Valentina, Scartozzi, Mario, Cascinu, Stefano, and Casadei-Gardini, Andrea

Published
2023
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19. Clinical outcomes with atezolizumab plus bevacizumab or lenvatinib in patients with hepatocellular carcinoma: a multicenter real-world study

Author

Persano, Mara, Rimini, Margherita, Tada, Toshifumi, Suda, Goki, Shimose, Shigeo, Kudo, Masatoshi, Cheon, Jaekyung, Finkelmeier, Fabian, Lim, Ho Yeong, Rimassa, Lorenza, Presa, José, Masi, Gianluca, Yoo, Changhoon, Lonardi, Sara, Tovoli, Francesco, Kumada, Takashi, Sakamoto, Naoya, Iwamoto, Hideki, Aoki, Tomoko, Chon, Hong Jae, Himmelsbach, Vera, Pressiani, Tiziana, Kawaguchi, Takumi, Montes, Margarida, Vivaldi, Caterina, Soldà, Caterina, Piscaglia, Fabio, Hiraoka, Atsushi, Sho, Takuya, Niizeki, Takashi, Nishida, Naoshi, Steup, Christoph, Iavarone, Massimo, Di Costanzo, Giovanni, Marra, Fabio, Scartozzi, Mario, Tamburini, Emiliano, Cabibbo, Giuseppe, Foschi, Francesco Giuseppe, Silletta, Marianna, Hirooka, Masashi, Kariyama, Kazuya, Tani, Joji, Atsukawa, Masanori, Takaguchi, Koichi, Itobayashi, Ei, Fukunishi, Shinya, Tsuji, Kunihiko, Ishikawa, Toru, Tajiri, Kazuto, Ochi, Hironori, Yasuda, Satoshi, Toyoda, Hidenori, Ogawa, Chikara, Nishimura, Takashi, Hatanaka, Takeshi, Kakizaki, Satoru, Shimada, Noritomo, Kawata, Kazuhito, Tada, Fujimasa, Ohama, Hideko, Nouso, Kazuhiro, Morishita, Asahiro, Tsutsui, Akemi, Nagano, Takuya, Itokawa, Norio, Okubo, Tomomi, Arai, Taeang, Imai, Michitaka, Kosaka, Hisashi, Naganuma, Atsushi, Koizumi, Yohei, Nakamura, Shinichiro, Kaibori, Masaki, Iijima, Hiroko, Hiasa, Yoichi, Cammarota, Antonella, Burgio, Valentina, Cascinu, Stefano, and Casadei-Gardini, Andrea

Published
2023
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20. Hyperplane families creating envelopes

Author

Nishimura, Takashi

Subjects
Mathematics - Geometric Topology, Mathematics - Differential Geometry, 57R45, 58C25
Abstract

A simple geometric mechanism: "the locus of intersections of perpendicular bisectors and normal lines", often arises in many guises in Nonlinear Sciences. In this paper, a new application of this simple geometric mechanism is given. Namely, we show that this mechanism gives answers to all four basic problems on envelopes created by hyperplane families (existence problem, representation problem, equivalence problem of definitions, uniqueness problem) at once., Comment: Minor revision. 28 pages, 14 figures, to appear in Nonlinearity

Published
2021
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22. Randomized Phase II Trial of Amrubicin Plus Irinotecan Versus Cisplatin Plus Irinotecan in Chemo-naïve Patients With Extensive-Disease Small-Cell Lung Cancer: Results of the Japan Multinational Trial Organization (JMTO) LC 08-01

Author

Yoshioka, Hiroshige, Ishida, Tadashi, Atagi, Shinji, Tamiya, Akihiro, Nishimura, Takashi, Iwamoto, Yasuo, Kanehara, Masashi, Kim, Young Hak, Korogi, Yohei, Tomii, Keisuke, Katakami, Nobuyuki, Komuta, Kiyoshi, Nishikawa, Masanori, Gemma, Akihiko, Yamaki, Kenichi, Kawahara, Masaaki, Miyakoshi, Chisato, and Mio, Tadashi

Published
2024
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24. Real-World Data for Atezolizumab Plus Bevacizumab in Unresectable Hepatocellular Carcinoma: How Does Adherence to the IMbrave150 Trial Inclusion Criteria Impact Prognosis?

Author

Rimini, Margherita, Persano, Mara, Tada, Toshifumi, Suda, Goki, Shimose, Shigeo, Kudo, Masatoshi, Cheon, Jaekyung, Finkelmeier, Fabian, Lim, Ho Yeong, Presa, José, Masi, Gianluca, Yoo, Changhoon, Lonardi, Sara, Piscaglia, Fabio, Kumada, Takashi, Sakamoto, Naoya, Iwamoto, Hideki, Aoki, Tomoko, Chon, Hong Jae, Himmelsbach, Vera, Pressiani, Tiziana, Montes, Margarida, Vivaldi, Caterina, Soldà, Caterina, Hiraoka, Atsushi, Sho, Takuya, Niizeki, Takashi, Nishida, Naoshi, Steup, Christoph, Hirooka, Masashi, Kariyama, Kazuya, Tani, Joji, Atsukawa, Masanori, Takaguchi, Koichi, Itobayashi, Ei, Fukunishi, Shinya, Tsuji, Kunihiko, Ishikawa, Toru, Tajiri, Kazuto, Ochi, Hironori, Yasuda, Satoshi, Toyoda, Hidenori, Ogawa, Chikara, Nishimura, Takashi, Hatanaka, Takeshi, Kakizaki, Satoru, Shimada, Noritomo, Kawata, Kazuhito, Tada, Fujimasa, Ohama, Hideko, Nouso, Kazuhiro, Morishita, Asahiro, Tsutsui, Akemi, Nagano, Takuya, Itokawa, Norio, Okubo, Tomomi, Arai, Taeang, Imai, Michitaka, Kosaka, Hisashi, Naganuma, Atsushi, Koizumi, Yohei, Nakamura, Shinichiro, Kaibori, Masaki, Iijima, Hiroko, Hiasa, Yoichi, Burgio, Valentina, Rimassa, Lorenza, Scartozzi, Mario, Cascinu, Stefano, and Casadei-Gardini, Andrea

Published
2023
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26. Spherical Separation Theorem

Author

Han, Huhe and Nishimura, Takashi

Subjects
Mathematics - Metric Geometry
Abstract

In this paper, it is shown that for any two non-empty closed (resp., open) and spherical convex subsets $\mathcal{W}_1, \mathcal{W}_2$ of $S^n$, the intersection $\mathcal{W}_1\cap \mathcal{W}_2$ is empty if and only if the subset $\{P\in S^n\; |\; P\cdot Q>0 \mbox{ for any } Q\in \mathcal{W}_1 \mbox{ and } P\cdot R<0 \mbox{ for any } R\in \mathcal{W}_2\}$ is non-empty, open (resp., closed) and spherical convex., Comment: 6 pages, 1 figure

Published
2020

27. Development and validation of a modified albumin–bilirubin grade and α-fetoprotein score (mALF score) for hepatocellular carcinoma patients receiving atezolizumab and bevacizumab

Author

Hatanaka, Takeshi, Kakizaki, Satoru, Hiraoka, Atsushi, Tada, Toshifumi, Hirooka, Masashi, Kariyama, Kazuya, Tani, Joji, Atsukawa, Masanori, Takaguchi, Koichi, Itobayashi, Ei, Fukunishi, Shinya, Tsuji, Kunihiko, Ishikawa, Toru, Tajiri, Kazuto, Ochi, Hironori, Yasuda, Satoshi, Toyoda, Hidenori, Ogawa, Chikara, Nishimura, Takashi, Shimada, Noritomo, Kawata, Kazuhito, Kosaka, Hisashi, Tanaka, Takaaki, Ohama, Hideko, Nouso, Kazuhiro, Morishita, Asahiro, Tsutsui, Akemi, Nagano, Takuya, Itokawa, Norio, Okubo, Tomomi, Arai, Taeang, Imai, Michitaka, Naganuma, Atsushi, Koizumi, Yohei, Nakamura, Shinichiro, Kaibori, Masaki, Iijima, Hiroko, Hiasa, Yoichi, and Kumada, Takashi

Published
2023
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29. Sequential therapies after atezolizumab plus bevacizumab or lenvatinib first-line treatments in hepatocellular carcinoma patients

Author

Persano, Mara, Rimini, Margherita, Tada, Toshifumi, Suda, Goki, Shimose, Shigeo, Kudo, Masatoshi, Cheon, Jaekyung, Finkelmeier, Fabian, Lim, Ho Yeong, Presa, José, Masi, Gianluca, Yoo, Changhoon, Lonardi, Sara, Tovoli, Francesco, Kumada, Takashi, Sakamoto, Naoya, Iwamoto, Hideki, Aoki, Tomoko, Chon, Hong Jae, Himmelsbach, Vera, Niizeki, Takashi, Montes, Margarida, Vivaldi, Caterina, Soldà, Caterina, Stefanini, Bernardo, Hiraoka, Atsushi, Sho, Takuya, Nishida, Naoshi, Steup, Christoph, Iavarone, Massimo, Di Costanzo, Giovanni, Marra, Fabio, Tamburini, Emiliano, Cabibbo, Giuseppe, Foschi, Francesco Giuseppe, Silletta, Marianna, Hirooka, Masashi, Kariyama, Kazuya, Tani, Joji, Atsukawa, Masanori, Takaguchi, Koichi, Itobayashi, Ei, Fukunishi, Shinya, Tsuji, Kunihiko, Ishikawa, Toru, Tajiri, Kazuto, Ochi, Hironori, Yasuda, Satoshi, Toyoda, Hidenori, Ogawa, Chikara, Nishimura, Takashi, Hatanaka, Takeshi, Kakizaki, Satoru, Shimada, Noritomo, Kawata, Kazuhito, Tada, Fujimasa, Ohama, Hideko, Nouso, Kazuhiro, Morishita, Asahiro, Tsutsui, Akemi, Nagano, Takuya, Itokawa, Norio, Okubo, Tomomi, Arai, Taeang, Imai, Michitaka, Kosaka, Hisashi, Naganuma, Atsushi, Koizumi, Yohei, Nakamura, Shinichiro, Kaibori, Masaki, Iijima, Hiroko, Hiasa, Yoichi, Campani, Claudia, Amadeo, Elisabeth, Rossari, Federico, Burgio, Valentina, Cascinu, Stefano, Scartozzi, Mario, and Casadei-Gardini, Andrea

Published
2023
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31. Anti-orthotomics of frontals and their applications

Author

Janeczko, Stanisław and Nishimura, Takashi

Subjects
Mathematics - Differential Geometry, Mathematical Physics, 57R45, 58C25, 53A40
Abstract

Let $f: N^n\to \mathbb{R}^{n+1}$ be a frontal with its Gauss mapping $\nu: N\to S^n$ and let $P\in \mathbb{R}^{n+1}$ be a point such that $(f(x)-P)\cdot \nu(x) \ne 0$ for any $x\in N$. In this paper, for the mapping $\widetilde{f}: N\to \mathbb{R}^{n+1}$ defined by $$ \widetilde{f}(x)=f(x)-\frac{||f(x)-P||^2}{2(f(x)-P) \cdot \nu(x)}\nu(x), $$ the following four are shown. (1) $\widetilde{f}$ is a frontal with its Gauss mapping $\widetilde{\nu}(x)=\frac{f(x)-P}{||f(x)-P||}$ at $\widetilde{f}(x)$. (2) $\widetilde{f}$ is the unique anti-orthotomic of $f$ relative to $P$. (3) The property $(\widetilde{f}(x)-P)\cdot \widetilde{\nu}(x)\ne 0 $ holds for any $x\in N$. (4) The equality $||\widetilde{f}(x)-P||=||\widetilde{f}(x)-f(x)||$ holds for any $x\in N$. Moreover, three applications of the main result are given. As the first application, a generalization of Cahn-Hoffman vector formula is given. The second application is to clarify an optical meaning of anti-orthotomics. The third application gives a criterion to be a front for a given frontal., Comment: 17 pages, 5 figures; explanations added for sections 1 and 3, e-mail address of 2nd author changed, results unchanged

Published
2019

32. Spherical orthotomic curve-germs

Author

Liu, Xihe and Nishimura, Takashi

Subjects
Mathematics - Geometric Topology, Mathematics - Differential Geometry, 57R45, 58C25, 53A40, 53A04
Abstract

In this paper, it is shown that for an $n$-dimensional spherical unit speed curve $\gamma: I\to S^n$, a given point $P \in S^n$ and a point $s_0$ of the open interval $I$, the spherical orthotomic curve-germ $ort_{\gamma, P}: (I, s_0)\to S^n$ of $\gamma$ relative to $P$ is $\mathcal{L}$-equivalent to the spherical pedal curve-germ $ped_{\gamma, P}: (I, s_0)\to S^n$ of $\gamma$ relative to $P$ (resp., the spherical dual curve-germ ${\bf u}_n: (I, s_0)\to S^n$ of $\gamma$) if and only if $P\ne \pm{\bf u}_n(s_0)$ (resp., if $P= \pm{\bf u}_n(s_0)$)., Comment: 10 pages, 2 figures

Published
2019

33. Prognostic impact of C-reactive protein and alpha-fetoprotein in immunotherapy score in hepatocellular carcinoma patients treated with atezolizumab plus bevacizumab: a multicenter retrospective study

Author

Hatanaka, Takeshi, Kakizaki, Satoru, Hiraoka, Atsushi, Tada, Toshifumi, Hirooka, Masashi, Kariyama, Kazuya, Tani, Joji, Atsukawa, Masanori, Takaguchi, Koichi, Itobayashi, Ei, Fukunishi, Shinya, Tsuji, Kunihiko, Ishikawa, Toru, Tajiri, Kazuto, Ochi, Hironori, Yasuda, Satoshi, Toyoda, Hidenori, Ogawa, Chikara, Nishimura, Takashi, Shimada, Noritomo, Kawata, Kazuhito, Kosaka, Hisashi, Tanaka, Takaaki, Ohama, Hideko, Nouso, Kazuhiro, Morishita, Asahiro, Tsutsui, Akemi, Nagano, Takuya, Itokawa, Norio, Okubo, Tomomi, Arai, Taeang, Imai, Michitaka, Naganuma, Atsushi, Koizumi, Yohei, Nakamura, Shinichiro, Joko, Kouji, Kaibori, Masaki, Iijima, Hiroko, Hiasa, Yoichi, and Kumada, Takashi

Published
2022
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34. ABC: a novel algorithm to stratify decompensation risk in patients with compensated advanced chronic liver disease (CHESS2108): an international, multicenter cohort study

Author

Liu, Chuan, Li, Jia, Wong, Yu Jun, Xie, Qing, Hirooka, Masashi, Enomoto, Hirayuki, Kim, Tae Hyung, Hanafy, Amr Shaaban, He, Ruiling, Koizumi, Yohei, Hiasa, Yoichi, Nishimura, Takashi, Iijima, Hiroko, Jung, Young Kul, Yim, Hyung Joon, Ma, Jianzhong, Zeng, Qing-Lei, Sarin, Shiv Kumar, and Qi, Xiaolong

Published
2022
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36. Correction to: Development and validation of a modified albumin–bilirubin grade and α-fetoprotein score (mALF score) for hepatocellular carcinoma patients receiving atezolizumab and bevacizumab

Author

Hatanaka, Takeshi, Kakizaki, Satoru, Hiraoka, Atsushi, Tada, Toshifumi, Hirooka, Masashi, Kariyama, Kazuya, Tani, Joji, Atsukawa, Masanori, Takaguchi, Koichi, Itobayashi, Ei, Fukunishi, Shinya, Tsuji, Kunihiko, Ishikawa, Toru, Tajiri, Kazuto, Ochi, Hironori, Yasuda, Satoshi, Toyoda, Hidenori, Ogawa, Chikara, Nishimura, Takashi, Shimada, Noritomo, Kawata, Kazuhito, Kosaka, Hisashi, Tanaka, Takaaki, Ohama, Hideko, Nouso, Kazuhiro, Morishita, Asahiro, Tsutsui, Akemi, Nagano, Takuya, Itokawa, Norio, Okubo, Tomomi, Arai, Taeang, Imai, Michitaka, Naganuma, Atsushi, Koizumi, Yohei, Nakamura, Shinichiro, Kaibori, Masaki, Iijima, Hiroko, Hiasa, Yoichi, and Kumada, Takashi

Published
2023
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37. Atezolizumab plus bevacizumab versus lenvatinib for unresectable hepatocellular carcinoma: a large real-life worldwide population

Author

Casadei-Gardini, Andrea, Rimini, Margherita, Tada, Toshifumi, Suda, Goki, Shimose, Shigeo, Kudo, Masatoshi, Cheon, Jaekyung, Finkelmeier, Fabian, Lim, Ho Yeong, Rimassa, Lorenza, Presa, José, Masi, Gianluca, Yoo, Changhoon, Lonardi, Sara, Tovoli, Francesco, Kumada, Takashi, Sakamoto, Naoya, Iwamoto, Hideki, Aoki, Tomoko, Chon, Hong Jae, Himmelsbach, Vera, Pressiani, Tiziana, Montes, Margarida, Vivaldi, Caterina, Soldà, Caterina, Piscaglia, Fabio, Hiraoka, Atsushi, Sho, Takuya, Niizeki, Takashi, Nishida, Naoshi, Steup, Christoph, Iavarone, Massimo, Di Costanzo, Giovanni, Marra, Fabio, Scartozzi, Mario, Tamburini, Emiliano, Cabibbo, Giuseppe, Foschi, Francesco Giuseppe, Silletta, Marianna, Hirooka, Masashi, Kariyama, Kazuya, Tani, Joji, Atsukawa, Masanori, Takaguchi, Koichi, Itobayashi, Ei, Fukunishi, Shinya, Tsuji, Kunihiko, Ishikawa, Toru, Tajiri, Kazuto, Ochi, Hironori, Yasuda, Satoshi, Toyoda, Hidenori, Ogawa, Chikara, Nishimura, Takashi, Hatanaka, Takeshi, Kakizaki, Satoru, Shimada, Noritomo, Kawata, Kazuhito, Tada, Fujimasa, Ohama, Hideko, Nouso, Kazuhiro, Morishita, Asahiro, Tsutsui, Akemi, Nagano, Takuya, Itokawa, Norio, Okubo, Tomomi, Arai, Taeang, Imai, Michitaka, Kosaka, Hisashi, Naganuma, Atsushi, Koizumi, Yohei, Nakamura, Shinichiro, Kaibori, Masaki, Iijima, Hiroko, Hiasa, Yoichi, Burgio, Valentina, Persano, Mara, Della Corte, Angelo, Ratti, Francesca, De Cobelli, Francesco, Aldrighetti, Luca, Cascinu, Stefano, and Cucchetti, Alessandro

Published
2023
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39. 5-Fluorouracil plus L-leucovorin and oxaliplatin treatment for esophageal squamous cell carcinoma: A multicenter retrospective study

Author

Shiraishi, Kazuhiro, primary, Okada, Mao, additional, Yamamoto, Shun, additional, Matsubara, Yuki, additional, Masuishi, Toshiki, additional, Shimozaki, Keitaro, additional, Yamamoto, Yoshiyuki, additional, Hirose, Suguru, additional, Sugiyama, Keiji, additional, Furuta, Mitsuhiro, additional, Machida, Nozomu, additional, Takahashi, Naoki, additional, Yoshii, Takako, additional, Kito, Yosuke, additional, Tsuzuki, Takao, additional, Boku, Shogen, additional, Tsuchihashi, Kenji, additional, Akinori, Sugaya, additional, Takayama, Toshizo, additional, Komori, Azusa, additional, Mitani, Seiichiro, additional, Matsumoto, Toshihiko, additional, Hirata, Kenro, additional, and Nishimura, Takashi, additional

Published
2024
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40. Jacobian-squared function-germs

Author

Nishimura, Takashi

Subjects
Mathematics - Classical Analysis and ODEs, 57R45, 58K05
Abstract

In this paper, it is shown that, for any equidimensional $C^\infty$ map-germ $f: (\mathbb{R}^n,0)\to (\mathbb{R}^n,0)$, the map-germ $F: (\mathbb{R}^n, 0) \to \mathbb{R}^n\times\mathbb{R}^{\ell}$ defined by $F(x)=\left(f(x), \mu_1(x){|Jf|^2(x)}, \cdots, \mu_\ell(x){|Jf|^2(x)}\right)$ is always a frontal; where $\mu_i$ is a $C^\infty$ function-germ and $|Jf|$ is the Jacobian-determinant of $f$. Moreover, it is also shown that when the multiplicity of $f$ is less than or equal to $3$, any frontal constructed from $f$ must be $\mathcal{A}$-equivalent to a frontal $F$ of the above form., Comment: 13 pages

Published
2018

42. Generic singularities of spherical orthotomic curves associated with spherical pedal curves

Author

Liu, Xihe and Nishimura, Takashi

Subjects
Mathematics - Differential Geometry
Abstract

For the n-dimensional spherical pedal curve $ped_{\gamma,P}$ with respect to an n-dimensional spherical unit speed curve $\gamma$ and a given point $P \in S^n$, we define the spherical orthotomic curve of $\gamma$ relative to the point $P$, and classify singularities of spherical orthotomic curves., Comment: This paper has been withdrawn by the author due to important improvements to be done

Published
2018

44. Artificial intelligence (AI) models for the ultrasonographic diagnosis of liver tumors and comparison of diagnostic accuracies between AI and human experts

Author

Nishida, Naoshi, Yamakawa, Makoto, Shiina, Tsuyoshi, Mekada, Yoshito, Nishida, Mutsumi, Sakamoto, Naoya, Nishimura, Takashi, Iijima, Hiroko, Hirai, Toshiko, Takahashi, Ken, Sato, Masaya, Tateishi, Ryosuke, Ogawa, Masahiro, Mori, Hideaki, Kitano, Masayuki, Toyoda, Hidenori, Ogawa, Chikara, and Kudo, Masatoshi

Published
2022
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46. Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti

Author

Inaba, Kazue, Ebihara, Kana, Senda, Miki, Yoshino, Ryunosuke, Sakuma, Chisako, Koiwai, Kotaro, Takaya, Daisuke, Watanabe, Chiduru, Watanabe, Akira, Kawashima, Yusuke, Fukuzawa, Kaori, Imamura, Riyo, Kojima, Hirotatsu, Okabe, Takayoshi, Uemura, Nozomi, Kasai, Shinji, Kanuka, Hirotaka, Nishimura, Takashi, Watanabe, Kodai, Inoue, Hideshi, Fujikawa, Yuuta, Honma, Teruki, Hirokawa, Takatsugu, Senda, Toshiya, and Niwa, Ryusuke

Published
2022
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47. Simultaneous smoothness and simultaneous stability of a $C^\infty$ strictly convex integrand and its dual

Author

Batista, Erica Boizan, Han, Huhe, and Nishimura, Takashi

Subjects
Mathematics - Geometric Topology, 52A05, 52A55, 58K05, 58K30
Abstract

In this paper, we investigate simultaneous properties of a convex integrand $\gamma$ and its dual $\delta$. The main results are the following three. (1) For a $C^\infty$ convex integrand $\gamma: S^n\to \mathbb{R}_+$, its dual convex integrand $\delta: S^n\to \mathbb{R}_+$ is of class $C^\infty$ if and only if $\gamma$ is a strictly convex integrand. (2) Let $\gamma: S^n\to \mathbb{R}_+$ be a $C^\infty$ strictly convex integrand. Then, $\gamma$ is stable if and only if its dual convex integrand $\delta: S^n\to \mathbb{R}_+$ is stable. (3) Let $\gamma: S^n\to \mathbb{R}_+$ be a $C^\infty$ strictly convex integrand. Suppose that $\gamma$ is stable. Then, for any $i$ $(0\le i\le n)$, a point $\theta_0\in S^n$ is a non-degenerate critical point of $\gamma$ with Morse index $i$ if and only if its antipodal point $-\theta_0\in S^n$ is a non-degenerate critical point of the dual convex integrand $\delta$ with Morse index $(n-i)$., Comment: 19 pages, 3 figures

Published
2017

48. Predictive factors and survival outcome of conversion therapy for unresectable hepatocellular carcinoma patients receiving atezolizumab and bevacizumab: Comparative analysis of conversion, partial response and complete response patients.

Author

Hatanaka, Takeshi, Kakizaki, Satoru, Hiraoka, Atsushi, Tada, Toshifumi, Hirooka, Masashi, Kariyama, Kazuya, Tani, Joji, Atsukawa, Masanori, Takaguchi, Koichi, Itobayashi, Ei, Fukunishi, Shinya, Tsuji, Kunihiko, Ishikawa, Toru, Tajiri, Kazuto, Toyoda, Hidenori, Ogawa, Chikara, Nishikawa, Hiroki, Nishimura, Takashi, Kawata, Kazuhito, and Kosaka, Hisashi

Subjects
CONVERSION therapy, NEUTROPHIL lymphocyte ratio, OVERALL survival, HEPATOCELLULAR carcinoma, SURVIVAL rate, BEVACIZUMAB
Abstract

Summary: Aim: This study aims to investigate the predictive factors for conversion therapy in patients with unresectable hepatocellular carcinoma (uHCC) and to evaluate the prognosis of conversion cases by comparing them with partial response (PR) and complete response (CR) cases. Methods: In this retrospective multicentre study, we included a total of 946 uHCC patients treated with atezolizumab and bevacizumab (Atez/Bev) from September 2020 to September 2023. Results: Out of the patients, 43 (4.5%) received conversion therapy following Atez/Bev treatment. The overall response rate was 65.1% and 23.7% in the conversion and non‐conversion group, respectively, with a statistical significance (p < 0.001). Multivariate analyses identified that BCLC stage B or an earlier stage (p = 0.045), absence of macrovascular invasion and extrahepatic spread (p = 0.045), and a low value of neutrophil to lymphocyte ratio (p = 0.04) were significantly favourable predictive factors associated with conversion therapy. The conversion group showed significantly better survival compared to the non‐conversion group (p < 0.001). In the landmark analysis at 6, 12 and 18 months, the conversion group exhibited better survival compared to PR patients in the non‐conversion group (p = 0.04, 0.01 and 0.03, respectively) and there were no significant differences in the overall survival (OS) between the conversion group and patients who achieved a CR (p = 0.7, 1.0 and 0.3, respectively). Conclusions: Patients with low tumour burden and low value of NLR were more likely to undergo conversion therapy. The OS of patients undergoing conversion therapy showed better survival compared to those achieving PR and was comparable to those with CR patients. Conversion therapy could be considered if feasible. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Feasibility of Double-Deployment Small-Diameter Covered Metallic Stent for Malignant Distal Biliary Obstruction (with Video).

Author

Nakano, Ryota, Shiomi, Hideyuki, Okamoto, Mamiko, Kawase, Yuta, Yoshihara, Kohei, Yoshioka, Ryota, Kawata, Shoki, Yuri, Yukihisa, Takashima, Tomoyuki, Aizawa, Nobuhiro, Ikeda, Naoto, Nishimura, Takashi, Fukunishi, Shinya, and Enomoto, Hirayuki

Subjects
PANCREATIC duct, BILE ducts, MEDICAL drainage, UNIVERSITY hospitals, CHOLECYSTITIS
Abstract

Background/Objectives: Covered self-expandable metallic stents (CSEMS) are commonly used to treat malignant distal biliary obstructions. A 10-mm CSEMS carries the risk of obstructing the pancreatic and cystic duct orifices by adhering to the bile duct; therefore, postoperative pancreatitis and cholecystitis are reported to occur at a certain frequency. We have adopted a new drainage technique for malignant distal biliary obstruction called "double-slim SEMS stenting" (DSS), where two small-diameter CSEMS are placed side-by-side. We aimed to compare the efficacy and safety of biliary drainage using DSS with those of conventional CSEMS. Methods: In total, 50 patients who underwent endoscopic biliary drainage for malignant distal biliary obstructions between April 2019 and March 2022 at Hyogo Medical University Hospital were enrolled. Patients were divided into DSS and Conventional groups, and the technical success rate, clinical success rate, adverse events, success rate for reintervention, recurrent biliary obstruction (RBO) rate, and time to RBO (TRBO) were evaluated. Results: There were no significant differences in patient characteristics between the DSS (n = 20) and Conventional groups (n = 30). The technical and clinical success rates were 100% in the DSS group. The incidence of adverse events was not significantly different between the two groups (DSS/Conventional: 10.0% [2/20]/20.0% [6/30]) (p = 0.34). No acute cholecystitis was observed in the DSS group. The incidence rates of RBO were 30% (6/20) and 43% (13/30) in the DSS and Conventional groups, respectively (p = 0.92). The median TRBO in the DSS group was 378 days, while the TRBO in the Conventional group was 195 days (p = 0.03), resulting in significantly longer TRBO in the DSS group. Conclusions: DSS emerges as a viable and safe approach for biliary drainage in malignant distal biliary obstruction, demonstrating a lower incidence of adverse events and longer TRBO compared to conventional CSEMS. [ABSTRACT FROM AUTHOR]

Published
2024
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50. JCS/JSCVS/JCC/CVIT 2023 guideline focused update on indication and operation of PCPS/ECMO/IMPELLA.

Author

Nishimura, Takashi, Hirata, Yasutaka, Ise, Takayuki, Iwano, Hiroyuki, Izutani, Hironori, Kinugawa, Koichiro, Kitai, Takeshi, Ohno, Takayuki, Ohtani, Tomohito, Okumura, Takahiro, Ono, Minoru, Satomi, Kazuhiro, Shiose, Akira, Toda, Koichi, Tsukamoto, Yasumasa, Yamaguchi, Osamu, Fujino, Takeo, Hashimoto, Toru, Higashi, Haruhiko, and Higashino, Akihiro

Published
2024
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