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1. Report of the first seven agents in the I-SPY COVID trial: a phase 2, open label, adaptive platform randomised controlled trial

Author

Consortium, The I-SPY COVID, Files, D Clark, Aggarwal, Neil, Albertson, Timothy, Auld, Sara, Beitler, Jeremy R, Berger, Paul, Burnham, Ellen L, Calfee, Carolyn S, Cobb, Nathan, Crippa, Alessio, Discacciati, Andrea, Eklund, Martin, Esserman, Laura, Friedman, Eliot, Gandotra, Sheetal, Khan, Kashif, Koff, Jonathan, Kumar, Santhi, Liu, Kathleen D, Martin, Thomas R, Matthay, Michael A, Meyer, Nuala J, Obermiller, Timothy, Robinson, Philip, Russell, Derek, Thomas, Karl, Wong, Fum, Wunderink, Richard G, Wurfel, Mark M, Yen, Albert, Youssef, Fady A, Darmanian, Anita, Dzierba, Amy L, Garcia, Ivan, Gosek, Katarzyna, Madahar, Purnema, Mittel, Aaron M, Muir, Justin, Rosen, Amanda, Schicchi, John, Serra, Alexis L, Wahab, Romina, Gibbs, Kevin W, Landreth, Leigha, LaRose, Mary, Parks, Lisa, Wynn, Adina, Ittner, Caroline AG, Mangalmurti, Nilman S, Reilly, John P, Harris, Donna, Methukupally, Abhishek, Patel, Siddharth, Boerger, Lindsie, Kazianis, John, Higgins, Carrie, McKeehan, Jeff, Daniel, Brian, Fields, Scott, Hurst-Hopf, James, Jauregui, Alejandra, Swigart, Lamorna Brown, Blevins, Daniel, Nguyen, Catherine, Suarez, Alexis, Tanios, Maged A, Sarafian, Farjad, Shah, Usman, Adelman, Max, Creel-Bulos, Christina, Detelich, Joshua, Harris, Gavin, Nugent, Katherine, Spainhour, Christina, Yang, Philip, Haczku, Angela, Hardy, Erin, Harper, Richart, Morrissey, Brian, Sandrock, Christian, Budinger, GR Scott, Donnelly, Helen K, Singer, Benjamin D, Moskowitz, Ari, Coleman, Melissa, Levitt, Joseph, Lu, Ruixiao, Henderson, Paul, Asare, Adam, Dunn, Imogene, and Barragan, Alejandro Botello

Subjects
Health Services, Clinical Trials and Supportive Activities, Clinical Research, Good Health and Well Being, I-SPY COVID Consortium, Acute lung injury, Clinical trial, Respiratory insufficiency, SARS-CoV-2
Abstract

BackgroundAn urgent need exists to rapidly screen potential therapeutics for severe COVID-19 or other emerging pathogens associated with high morbidity and mortality.MethodsUsing an adaptive platform design created to rapidly evaluate investigational agents, hospitalised patients with severe COVID-19 requiring ≥6 L/min oxygen were randomised to either a backbone regimen of dexamethasone and remdesivir alone (controls) or backbone plus one open-label investigational agent. Patients were enrolled to the arms described between July 30, 2020 and June 11, 2021 in 20 medical centres in the United States. The platform contained up to four potentially available investigational agents and controls available for randomisation during a single time-period. The two primary endpoints were time-to-recovery (

Published
2023

2. I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations

Author

Files, Daniel Clark, Matthay, Michael A, Calfee, Carolyn S, Aggarwal, Neil R, Asare, Adam L, Beitler, Jeremy R, Berger, Paul A, Burnham, Ellen L, Cimino, George, Coleman, Melissa H, Crippa, Alessio, Discacciati, Andrea, Gandotra, Sheetal, Gibbs, Kevin W, Henderson, Paul T, Ittner, Caroline AG, Jauregui, Alejandra, Khan, Kashif T, Koff, Jonathan L, Lang, Julie, LaRose, Mary, Levitt, Joe, Lu, Ruixiao, McKeehan, Jeffrey D, Meyer, Nuala J, Russell, Derek W, Thomas, Karl W, Eklund, Martin, Esserman, Laura J, Liu, Kathleen D, Mittel, Aaron M, Yen, Albert F, Suarez, Alexis E, Serra, Alexis L, Amin, Alpesh N, Rosen, Amanda, Dzierba, Amy L, Haczku, Angela, Barker, Anna D, Weisman, Ariel R, Daniel, Brian M, Morrissey, Brian M, Jones, Chayse, Creel-Bulos, Christina, Angelucci, Christina M, Files, Daniel C, Ng, Diana, Youssef, Fady A, Chaparro-Rojas, Fredy, Harris, Gavin H, Barot, Harsh V, Su, Heny, Garcia, Ivan, Sutter, Jacqueline B, Dodin, Jamal, Lee, Jerry S, Kazianis, John, Reilly, John P, Detelich, Joshua F, Lang, Julie E, Muir, Justin, Gosek, Katarzyna, Nugent, Katherine L, Yee, Kimberly, Rodrigues, Laura G, Macias, Laura R, Orr, Lindsey A, Boerger, Lindsie L, Rosario-Remigio, Lissette, Kufa, Lucia, Huerta, Luis E, Tanios, Maged, Reyes, Maria B, Adelman, Max W, Juarez, Maya M, Jung, Michelle, Meyers, Michelle, Sternlieb, Mitchell P, Cobb, Nathan K, and Aggarwal, Neil

Subjects
Clinical Research, Clinical Trials and Supportive Activities, Good Health and Well Being, Bayes Theorem, COVID-19, Humans, Pandemics, Respiratory Distress Syndrome, Respiratory Insufficiency, SARS-CoV-2, Treatment Outcome, ISPY COVID Adaptive Platform Trial Network, undefined, adult intensive & critical care, clinical trials, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences
Abstract

IntroductionThe COVID-19 pandemic brought an urgent need to discover novel effective therapeutics for patients hospitalised with severe COVID-19. The Investigation of Serial studies to Predict Your Therapeutic Response with Imaging And moLecular Analysis (ISPY COVID-19 trial) was designed and implemented in early 2020 to evaluate investigational agents rapidly and simultaneously on a phase 2 adaptive platform. This manuscript outlines the design, rationale, implementation and challenges of the ISPY COVID-19 trial during the first phase of trial activity from April 2020 until December 2021.Methods and analysisThe ISPY COVID-19 Trial is a multicentre open-label phase 2 platform trial in the USA designed to evaluate therapeutics that may have a large effect on improving outcomes from severe COVID-19. The ISPY COVID-19 Trial network includes academic and community hospitals with significant geographical diversity across the country. Enrolled patients are randomised to receive one of up to four investigational agents or a control and are evaluated for a family of two primary outcomes-time to recovery and mortality. The statistical design uses a Bayesian model with 'stopping' and 'graduation' criteria designed to efficiently discard ineffective therapies and graduate promising agents for definitive efficacy trials. Each investigational agent arm enrols to a maximum of 125 patients per arm and is compared with concurrent controls. As of December 2021, 11 investigational agent arms had been activated, and 8 arms were complete. Enrolment and adaptation of the trial design are ongoing.Ethics and disseminationISPY COVID-19 operates under a central institutional review board via Wake Forest School of Medicine IRB00066805. Data generated from this trial will be reported in peer-reviewed medical journals.Trial registration numberNCT04488081.

Published
2022

3. α-Tocopherol Pharmacokinetics in Adults with Cystic Fibrosis: Benefits of Supplemental Vitamin C Administration

Author

Traber, Maret G, Leonard, Scott W, Vasu, Vihas T, Morrissey, Brian M, Lei, Huangshu, Atkinson, Jeffrey, and Cross, Carroll E

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Lung, Nutrition, Rare Diseases, Complementary and Integrative Health, Cystic Fibrosis, Clinical Trials and Supportive Activities, Clinical Research, Adult, Ascorbic Acid, Humans, Tocopherols, Vitamin E, Vitamins, alpha-Tocopherol, gamma-Tocopherol, vitamin E, carboxyethyl hydroxy chromanol, stable isotope-labeled vitamin E, Food Sciences, Clinical sciences, Nutrition and dietetics, Public health
Abstract

BackgroundNumerous abnormalities in cystic fibrosis (CF) could influence tocopherol absorption, transportation, storage, metabolism and excretion. We hypothesized that the oxidative distress due to inflammation in CF increases vitamin E utilization, which could be positively influenced by supplemental vitamin C administration.MethodsImmediately before and after receiving vitamin C (500 mg) twice daily for 3.5 weeks, adult CF patients (n = 6) with moderately advanced respiratory tract (RT) disease consumed a standardized breakfast with 30% fat and a capsule containing 50 mg each hexadeuterium (d6)-α- and dideuterium (d2)-γ-tocopheryl acetates. Blood samples were taken frequently up to 72 h; plasma tocopherol pharmacokinetics were determined. During both trials, d6-α- and d2-γ-tocopherols were similarly absorbed and reached similar maximal plasma concentrations ~18-20 h. As predicted, during vitamin C supplementation, the rates of plasma d6-α-tocopherol decline were significantly slower.ConclusionsThe vitamin C-induced decrease in the plasma disappearance rate of α-tocopherol suggests that vitamin C recycled α-tocopherol, thereby augmenting its concentrations. We conclude that some attention should be paid to plasma ascorbic acid concentrations in CF patients, particularly to those individuals with more advanced RT inflammatory disease and including those with severe exacerbations.

Published
2022

4. Report of the first seven agents in the I-SPY COVID trial: a phase 2, open label, adaptive platform randomised controlled trial

Author

Files, D. Clark, Aggarwal, Neil, Albertson, Timothy, Auld, Sara, Beitler, Jeremy R., Berger, Paul, Burnham, Ellen L., Calfee, Carolyn S., Cobb, Nathan, Crippa, Alessio, Discacciati, Andrea, Eklund, Martin, Esserman, Laura, Friedman, Eliot, Gandotra, Sheetal, Khan, Kashif, Koff, Jonathan, Kumar, Santhi, Liu, Kathleen D., Martin, Thomas R., Matthay, Michael A., Meyer, Nuala J., Obermiller, Timothy, Robinson, Philip, Russell, Derek, Thomas, Karl, Wong, Se Fum, Wunderink, Richard G., Wurfel, Mark M., Yen, Albert, Youssef, Fady A., Darmanian, Anita, Dzierba, Amy L., Garcia, Ivan, Gosek, Katarzyna, Madahar, Purnema, Mittel, Aaron M., Muir, Justin, Rosen, Amanda, Schicchi, John, Serra, Alexis L., Wahab, Romina, Gibbs, Kevin W., Landreth, Leigha, LaRose, Mary, Parks, Lisa, Wynn, Adina, Ittner, Caroline A.G., Mangalmurti, Nilman S., Reilly, John P., Harris, Donna, Methukupally, Abhishek, Patel, Siddharth, Boerger, Lindsie, Kazianis, John, Higgins, Carrie, McKeehan, Jeff, Daniel, Brian, Fields, Scott, Hurst-Hopf, James, Jauregui, Alejandra, Brown Swigart, Lamorna, Blevins, Daniel, Nguyen, Catherine, Suarez, Alexis, Tanios, Maged A., Sarafian, Farjad, Shah, Usman, Adelman, Max, Creel-Bulos, Christina, Detelich, Joshua, Harris, Gavin, Nugent, Katherine, Spainhour, Christina, Yang, Philip, Haczku, Angela, Hardy, Erin, Harper, Richart, Morrissey, Brian, Sandrock, Christian, Budinger, G. R. Scott, Donnelly, Helen K., Singer, Benjamin D., Moskowitz, Ari, Coleman, Melissa, Levitt, Joseph, Lu, Ruixiao, Henderson, Paul, Asare, Adam, Dunn, Imogene, and Botello Barragan, Alejandro

Published
2023
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6. Trend in Clinical Trial Participation During COVID-19: A Secondary Analysis of the I-SPY COVID Clinical Trial

Author

Yang, Philip, Dickert, Neal W., Haczku, Angela, Spainhour, Christine, Auld, Sara C., Aggarwal, Neil R., Albertson, Timothy, Auld, Sara, Beitler, Jeremy R., Berger, Paul, Burnham, Ellen L., Calfee, Carolyn S., Cobb, Nathan, Crippa, Alessio, Discacciati, Andrea, Eklund, Martin, Esserman, Laura, Files, D. Clark, Friedman, Eliot, Gandotra, Sheetal, Khan, Kashif, Koff, Jonathan, Kumar, Santhi, Liu, Kathleen D., Martin, Thomas R., Matthay, Michael A., Meyer, Nuala J., Obermiller, Timothy, Robinson, Philip, Russell, Derek, Thomas, Karl, Wong, Se Fum, Wunderink, Richard G., Wurfel, Mark M., Yen, Albert, Youssef, Fady A., Darmanian, Anita, Dzierba, Amy L., Garcia, Ivan, Gosek, Katarzyna, Madahar, Purnema, Mittel, Aaron M., Muir, Justin, Roden, Amanda, Schicchi, John, Serra, Alexis L., Wahab, Romina, Gibbs, Kevin W., Landreth, Leigha, LaRose, Mary, Parks, Lisa, Wynn, Adina, Ittner, Caroline A. G., Mangalmurti, Nilam S., Reilly, John P., Harris, Donna, Methukupally, Abhishek, Patel, Siddharth, Boerger, Lindsie, Kazianis, John, Higgins, Carrie, McKeehan, Jeff, Daniel, Brian, Fields, Scott, Hurst-Hopf, James, Jauregui, Alejandra, Swigart, Lamorna Brown, Belvins, Daniel, Nguyen, Catherine, Suarez, Alexis, Tanios, Maged A., Sarafian, Farjad, Shah, Usman, Adelman, Max, Creel-Bulos, Christina, Detelich, Joshua, Harris, Gavin, Nugent, Katherine, Spainhour, Christine, Yang, Philip, Haczku, Angela, Hardy, Erin, Harper, Richart, Morrissey, Brian, Sandrock, Christian, Budinger, G. R. Scott, Donnelly, Helen K., Singer, Benjamin D., Moskowitz, Ari, Coleman, Melissa, Levitt, Joseph, Lu, Ruixiao, Henderson, Paul, Asare, Adam, Dunn, Imogene, and Barragan, Alejandro Botello

Published
2023
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7. Worldwide Disparities in Recovery of Cardiac Testing 1 Year Into COVID-19

Author

Einstein, Andrew J., Paez, Diana, Dondi, Maurizio, Better, Nathan, Cerci, Rodrigo, Dorbala, Sharmila, Karthikeyan, Ganesan, Pascual, Thomas N.B., Shaw, Leslee J., Villines, Todd C., Vitola, Joao V., Williams, Michelle C., Pynda, Yaroslav, Hinterleitner, Gerd, Lu, Yao, Morozova, Olga, Xu, Zhuoran, Hirschfeld, Cole B., Cohen, Yosef, Erinne, Ikenna, Malkovskiy, Eli, Randazzo, Michael, Sewanan, Lorenzo, Shetty, Mrinali, Choi, Andrew, Lopez-Mattei, Juan, Parwani, Purvi, Goda, Artan, Shirka, Ervina, Bouyoucef, Salah, Chelghoum, Lydia, Mansouri, Farouk, Medjahedi, Abdelkader, Naili, Qais, Ridouh, Mokhtar, Alasia, Diego, Alberghina, Lucia, Aramayo, Natalia, Buchara, Diego, Busso, Franco Gabriel, Bustos Rivadero, Jose Javier, Camilletti, Jorge, Campanelli, Hugo, Campisi, Roxana, Castro, Ricardo Belisario, Daicz, Mariana, del Riego, Horacio, Dragonetti, Laura, Echazarreta, Diego, Erriest, Juan, Faccio, Fernando, Facello, Adolfo, Gallegos, Hugo, Geronazzo, Ricardo, Glait, Horacio, Hasbani, Victor, Jäger, Victor, Lewkowicz, Julio Manuel, Lotti, Jose, Maciel, Neiva, Masoli, Osvaldo, Mastrovito, Edgardo, Medus, Maria, Merani, Maria Fernanda, Molteni, Susana, Montecinos, Marcos, Parisi, Gustavo, Sueldo, Claudio Pereyra, Perez de Arenaza, Diego, Quintana, Luis, Radzinschi, Alejandro, Redruello, Marcela, Rodríguez, Marina, Rojas, Horacio, Acuña, Arturo Romero, Schere, Daniel, Traverso, Sonia, Vazquez, Gustavo, Zeffiro, Susana, Sakanyan, Mari, Beuzeville, Scott, Boktor, Raef, Crowley, Michael, Downie, D'Arne, Dwivedi, Girish, Elison, Barry, Farouque, Omar, Jasper, Kim, Joshi, Subodh, Lee, Joseph, Lee, Kenneth, Lui, Elaine, Mcconachie, Peter, Meaker, Joanne, Nandurkar, Dee, Neill, Johanne, O'Rourke, Edward, O'Sullivan, Patricia, Pandos, George, Premaratne, Manuja, Prior, David, Rutherford, Natalie, Saunders, Connor, Taubman, Kim, Tauro, Andrew, Taylor, Andrew, Theuerle, James, Thomas, Paul, Tow, Jonathan, Upton, Anthony, Vamadevan, Shankar, Wayne, Victor, Wegner, Eva Alina, Wong, David, Younger, John, Beitzke, Dietrich, Feuchtner, Gudrun, Sommer, Oliver, Weiss, Konrad, Maroz-Vadalazhskaya, Natallia, Tserakhau, Uladzimir, Homans, Filip, Van De Heyning, Caroline M., Araujo, Raúl, Soldat-Stankovic, Valentina, Stankovic, Sinisa, Almeida, Augusto, Anselmi, Carlos, Azevedo, Guilherme S.A., Bittencourt, Marcio Sommer, Pianta, Diego Bromfman, Cabeda, Estevan, Carreira, Lara, Coelho, Igor, de Amorim Fernandes, Fernando, de Lorenzo, Andrea, Delgado, Roberta, Erthal, Fernanda, Fernandes, Fabio, Fernandes, Juliano, Ferreira de Souza, Thiago, Foppa, Murilo, Matos Alves, Wilson Furlan, Gontijo, Cibele, Gottlieb, Ilan, Grossman, Gabriel, Albernaz Siqueira, Maria Helena, Nomura, Cesar Higa, Koga, Katia Hiromoto, Lima, Ronaldo, Lopes, Rafael, Marçal Filho, Hugo Humberto, Masiero, Paulo, Mastrocola, Luiz, Menezes de Siqueira, Maria Eduarda, Mesquita, Claudio, Naves, Danilo, Penna, Filipe, Pinto, Ibraim, Rocha, Thércio, Rocha, Juliana Leal, Rodrigues, Alfredo, Salioni, Leila, Sanches, Adelina, Santos, Marcelo, Da Silva, Leonardo Sara, Schvartzman, Paulo, Matushita, Cristina Sebastião, Senra, Tiago, Silva, Marcelo, Soares, Carlos Eduardo, Spiro, Bernardo, Suaide Silva, Carlos Eduardo, Torres, Rafael, Monte, Guilherme Urpia, Vilela, Andrea, Villa, Alexandre Volney, Vitola, Joao, Voss, Themissa, Waltrick, Roberto, Zapparoli, Marcello, Naseer, Hamid, Garcheva-Tsacheva, Marina, Ouattara, Tiémégna Florence, Thou, Sarameth, Varoeun, Soley, Abikhzer, Gad, Beanlands, Rob, Chetrit, Michael, Dabreo, Dominique, Dennie, Carole, Friedrich, Matthias, Hafez, Mohmmed Nassoh, Hanneman, Kate, Miller, Robert, Oikonomou, Anastasia, Roifman, Idan, Small, Gary, Tandon, Vikas, Trivedi, Adwait, White, James, Zukotynski, Katherine, Alay, Rita, Concha, Carmen, Massardo, Teresa, Abad, Pedro, Anzola, Kelly, Arturo, Harold, Benitez, Luis, Cadena, Alberto, Zamudio, Carlos Caicedo, Calderón, Antonio, Gutierrez Villamil, Claudia T., Jaimes, Claudia, Londono, Juan L., Lopez, Nelson, Merlano-Gaitan, Sonia, Murgieitio-Cabrera, Ramon, Valencia, Manuel, Vergel, Damiana, Santamaria, Alejandro Zuluaga, Solis, Felix, Batinic, Tonci, Franceschi, Maja, Paar, Maja Hrabak, Prpic, Marina, Felipe Batista, Cuba: Juan, Cabrera, Lazaro Omar, Peix, Amalia, Peña, Yamilé, Rochela Vázquez, Luis Manuel, Ntalas, Ioannis, Kaminek, Milan, Kincl, Vladimir, Lang, Otto, Abdulla, Jawdat, Bøttcher, Morten, Busk, Martin, Geisler, Uka, Gormsen, Lars C., Hansson, Nicolaj, Hess, Søren, Hove, Jens, Jensen, Lars Thorbjoern, Jensen, Magnus T., Kragholm, Kristian Hay, Nørgaard, Bjarne L., Øvrehus, Kristian, Rasmussen, Jan, Rønnow Sand, Niels Peter, Sondergaard, Hanne, Zaremba, Tomas, Speckter, Herwin, Amores, Nelson, Velez, Mayra Sanchez, Alrahman, Taghreed Abd, Elsamad, Sherif Abd, Abdelfattah, Alia, Allam, Adel, Elkaffas, Sameh, Hassan, Mona, Hussein, Elshaymaa, Ibrahim, Ahmed, Kandeel, Ahmed, Ali, Mohamed Mandour, Shaaban, Mahmoud, Flores, Camila, Gómez Leiva, Verónica Vanesa, Liiver, Anita, Larikka, Martti, Uusitalo, Valtteri, Agostini, Denis, Berger, Clothilde, Dietz, Matthieu, Hyafil, Fabien, Ohana, Mickaël, Prigent, Kevin, Regaieg, Hamza, Sarda-Mantel, Laure, H-Ici, Darach O., Ayetey, Harold, Angelidis, George, Fragkaki, Christina, Fragkiadaki, Chrysoula, Georgoulias, Panagiotis, Koutelou, Maria, Kyrozi, Elena, Lama, Niki, Prassopoulos, Vassilis, Spartalis, Michael, Zaglavara, Theodora, Gonzalez, Carla, Gutierrez, Goleat, Maldonado, Alejandro, Martinez, Yassine, Kovács, Attila, Szilveszter, Bálint, Banthia, Nilesh, Bhat, Vivek, Bhatia, Mona, Choudhury, Partha, Chowdekar, Vijay Sai, Christopher, Johann, Garg, Tushar, Goyal, Naresh Kumar, Gupta, Ripen Kumar, Gupta, Abhishek, Hephzibah, Julie, Jain, Shashank, Krupa, Jesu, Kumar, Parveen, Kumar, Sukriti, Lalchandani, Arati, Mishra, Animesh, Mishra, Vivaswan Dutt, Mohan, Parul, Ozair, Ahmad, Pandey, Shivani, Parameswaran, Ramanathapuram, Patel, Chetan, Patel, Tapan, Patel, Shivani, Vimala, Leena Robinson, Kumar Sarangi, Dr Pradosh, Sengupta, Shantanu, Sethi, Arvind, Sharma, Amit, Sharma, Awadhesh Kumar, Sharma, Punit, Shrigiriwar, Apurva, Singh, Santosh, Singh, Harpreet, Sood, Ashwani, Verma, Atul, Vyas, Ajay, Soeriadi, Erwin Affandi, Bun, Edison, Hutomo, Febby, Syawaluddin, Hilman, Yudistiro, Ryan, Albadr, Amjed, Assadi, Majid, Emami, Farshad, Emami-Ardekani, Alireza, Farzanehfar, Saeed, Jafari, Ramezan, Manafi-Farid, Reyhaneh, Tajik, Maryam, Arnson, Yoav, Fuchs, Shmuel, Goldkorn, Ronen, Kennedy, John, Leitman, Marina, Shalev, Aryeh, Acampa, Wanda, Albano, Domenico, Alongi, Pierpaolo, Arnone, Gaspare, Assante, Roberta, Baritussio, Anna, Bauckneht, Matteo, Bianco, Francesco, Bonfiglioli, Rachele, Bovenzi, Francesco, Bruno, Isabella, Bruno, Andrea, Busnardo, Elena, Califaretti, Elena, Casoni, Roberta, Censullo, Vittorio, Chierichetti, Franca, Chiocchi, Marcello, Cittanti, Corrado, Clemente, Alberto, Cuocolo, Alberto, De Rimini, Maria Luisa, De Vincentis, Giuseppe, Della Tommasina, Veronica, Dellegrottaglie, Santo, Erba, Paola Anna, Evangelista, Laura, Faggi, Lara, Faragasso, Evelina, Florimonte, Luigia, Frantellizzi, Viviana, Gatti, Marco, Gaudiano, Angela, Gelardi, Fabrizia, Gerali, Alberto, Gimelli, Alessia, Guglielmo, Marco, Leccisotti, Lucia, Liga, Riccardo, Liguori, Carlo, Longo, Giampiero, Maffione, Margherita, Marcassa, Claudio, Matassa, Giovanni, Mele, Donato, Milan, Elisa, Mircoli, Luca, Paccagnella, Andrea, Pacella, Sara, Padovano, Federica, Pellegrini, Dario, Pergola, Valeria, Pugliese, Luca, Quartuccio, Natale, Rampin, Lucia, Ricci, Fabrizio, Rubini, Giuseppe, Russo, Vincenzo, Sambuceti, Gianmario, Scatteia, Alessandra, Sciagrà, Roberto, Spidalieri, Gianluca, Stefanelli, Antonella, Tedeschi, Carlo, Ventroni, Guido, Baugh, Dainia, Madu, Ernest, Aikawa, Tadao, Asano, Hiroshi, Fujimoto, Shinichiro, Fujise, Koichiro, Fukushima, Yoshimitsu, Fukuyama, Kae, Ichikawa, Yasutaka, Ideguchi, Reiko, Iguchi, Nobuo, Imai, Masamichi, Ishimura, Hayato, Isobe, Satoshi, Ito, Kimiteru, Izawa, Yu, Kadokami, Toshiaki, Kasai, Tokuo, Kato, Takao, Kawamoto, Takashi, Kiryu, Shigeru, Kumita, Shinichiro, Manabe, Osamu, Maruno, Hirotaka, Matsumoto, Naoya, Miyagawa, Masao, Moroi, Masao, Nagamachi, Shigeki, Nakajima, Kenichi, Nakazato, Ryo, Nanasato, Mamoru, Naya, Masanao, Norikane, Takashi, Ohta, Yasutoshi, Otomi, Yoichi, Otsuka, Hideki, Oyama-Manabe, Noriko, Saito, Masaki, Sarai, Masayoshi, Sato, Junichi, Sato, Daisuke, Shiraishi, Shinya, Takanami, Kentaro, Takehana, Kazuya, Taniguchi, Yasuyo, Teragawa, Hiroki, Tomizawa, Nobuo, Umeji, Kyoko, Wakabayashi, Yasushi, Yamada, Shinichiro, Yamazaki, Shinya, Yoneyama, Tatsuya, Rawashdeh, Mohammad, Dautov, Tairkhan, Makhdomi, Khalid, Abass, Mostafa, Garashi, Masoud, Siraj, Qaisar, Kalnina, Marika, Haidar, Mohamad, Komiagiene, Renata, Kviecinskiene, Giedre, Vajauskas, Donatas, Karim, Noor Khairiah A., Doucoure, Mady, Reichmuth, Luise, Samuel, Anthony, Dieng, Mohamed Lemine, Naojee, Ambedhkar Shantaram, Hernandez, Estrella Aguilera, Alducin Tellez, Cesar Rene, Alexánderson-Rosas, Erick, Barragan, Erika, Cabada, Manuel, Calderón, Daniel, Carvajal-Juarez, Isabel, Esparza, José, Gama-Moreno, Manlio Gerardo, Quinto, Virginia Garcia, Gonzalez, Nelsy Coromoto, Herrera-Zarza, Mary Carmen, Meave, Aloha, Medina Verdugo, Jesus Gregorio, Melendez, Gabriela, Morales Murguia, Rafael Humberto, Navarro Quiroz, Carlos Salvador, Ornelas, Mario, Preciado-Anaya, Andres, Preciado-Gutiérrez, Oscar Ulises, Puente, Adriana, Salazar, Aristóteles Ramírez, Rosales Uvera, Sandra Graciela, Rosales-Uvera, Sandra, Serna Macias, Jose Antonio, Sierra-Galan, Lilia, Sierra-Galan, Lilia M., Tirado Alderete, Juan Carlos, Vallejo, Enrique, Faraggi, Marc, Sereegotov, Erdenechimeg, Ben Rais, Nouzha, Alaoui, Nadia Ismaili, Kyiphyu, Thiri, Oo, Su Thet, Win, Soe Myat, Zar, Htin, Ghimire, Ram, Neupane, Madhu, Glaudemans, Andor, Slart, Riemer, Verschure, Derk, Allen, Berry, Edmond, John, Mckenzie, Clare, Tie, Stuart, Van Pelt, Niels, Worthington, Kirsten, Young, Calum, Soli, Idrissa Adamou, Kana, Shehu, Onubogu, Uchenna, Sani, Mahmoud, Bråten, Anders Tjellaug, Jørgensen, Arve, Vassbotn, Hanne-Elin, Al Dhuhli, Humoud, Jawa, Zabah, Tag, Naima, Fatima, Shazia, Imran, Muhammad Babar, Younis, Muhammad Numair, Saadullah, Mohammad, Malo, Yariela Herrera, Lenturut-Katal, Dora, Castillo, Manuel, Ortellado, José, Akhter, Afroza, Cader, F. Aaysha, Hussain, Raihan, Khan, Saidur Rahman, Mandal, Tapati, Nasreen, Faria, An, Yunqiang, Cao, Dianbo, Gong, Lianggeng, Hou, Yang, Jia, Chongfu, Li, Tao, Li, Caiying, Liu, Hui, Liu, Wenya, Liu, Jinkang, Lu, Bin, Ng, Ming-Yen, Shi, Heshui, Tang, Chunxiang, Wang, Ximing, Wang, Zhaoqian, Wang, Yining, Wu, Jiang, Yi, Yan, Yuan, Li, Zhang, Tong, Zhang, Longjiang, Chavez, Edith, Cruz, Carlos, Llontop, Christian, Morales, Rosanna, Abrihan, Paz, Bustos-Barroso, Asela, Duldulao-Ogbac, Michele, Eduarte, Christopher, Obaldo, Jerry, Quinon, Alvin, San Juan, Belinda, San Juan, Carlo Joe, Sauler-Gomez, Marie Rhiamar, Uy, Mila, Kostkiewicz, Magdalena, Kunikowska, Jolanta, Teresinska, Anna, Urbanik, Tomasz, Bettencourt, Nuno, Fontes-Carvalho, Ricardo, Gavina, Cristina, Gonçalves, Lino, Macedo, Filipe, Moreno, Nuno, Sousa, Carla, Timoteo, Ana Teresa, Vidigal, Maria João, Al Heidous, Mahmoud, Ramanathan, Subramaniyan, Arnous, Samer, Aytani, Said, Byrne, Angela, Gleeson, Tadhg, Kerins, David, O'Brien, Julie, Bang, Ji-In, Bom, Henry, Cheon, Miju, Cheon, Gi Jeong, Cho, Sang-Geon, Hong, Chae Moon, Jeong, Yong Hyu, Kang, Won Jun, Kang, Yeon-Koo, Kim, Ji-Young, Oh, So Won, So, Young, Song, Ho-Chun, Won, Kyoung Sook, Yoo, Soo Woong, Mitevska, Irena, Vavlukis, Marija, Salobir, Barbara Gužic, Štalc, Monika, Benedek, Theodora, Pop, Marian, Stan, Claudiu, Ansheles, Alexey, Dariy, Olga, Gagarina, Nina, Itskovich, Irina, Karalkin, Anatoliy, Kokov, Alexander, Marina, Gulya, Migunova, Ekaterina, Pospelov, Viktor, Ryzhkova, Daria, Sayfullina, Guzaliya, Sergienko, Vladimir, Shurupova, Irina, Sinitsyn, Valentin, Vakhromeeva, Margarita, Valiullina, Nailia, Zavadovsky, Konstantin, Zhuravlev, Kirill, Abazid, Rami, Al Garni, Turki, Alasnag, Mirvat, Aljizeeri, Ahmed, Amer, Hamid, Amro, Ahmad, Hamdy, Hesham, Smettei, Osama, Saranovic, Dragana Sobic, Vlajkovic, Marina, Keng, Felix, See, Jason, Berecova, Zuzana, Mistinova, Jana Polakova, Evbuomwan, Osayande, Govender, Nerisha, Hack, Jonathan, Hadebe, Bawinile, Hlongwa, Khanyisile, Kaplan, Mitchell, Lakhi, Hoosen, Milos, Katarina, Modiselle, Moshe, More, Stuart, Muambadzi, Ntanganedzeni, Scholtz, Leonie, Barreiro-Perez, Manuel, Blanco, Isabel, Broncano, Jordi, Camarero, Alicia, Casáns-Tormo, Irene, De Haro, Javier, Flotats, Albert, García, Elia, Mendiguchia, Ceferino Gutierrez, Jimenez-Heffernan, Amelia, Leta, Ruben, Diaz, Javier Lopez, Vega, Luis Lumbreras, Manovel-Sánchez, Ana, Monzonis, Amparo Martinez, Patrut, Bianca, Pubul, Virginia, Perez, Ricardo Ruano, Zeidan, Nahla, Nanayakkara, Damayanthi, Suliman, Ahmed, Engblom, Henrik, Murtadha, Mustafa, Ostenfeld, Ellen, Simonsson, Magnus, Alkadhi, Hatem, Buechel, Ronny Ralf, Burger, Peter, Gräni, Christoph, Kamani, Christel, Kawel-Böhm, Nadine, Klaeser, Bernd, Manka, Robert, Prior, John, Kaewchur, Tawika, Khiewvan, Benjapa, Kositwattanarerk, Arpakorn, Namwongprom, Sirianong, Thientunyakit, Tanyaluck, Sayman, Haluk Burcak, Yüksel, Mahmut, Sebikali, Mugisha Julius, Okello, Emmy, Korol, Pavlo, Noverko, Iryna, Satyr, Maryna, Ahmad, Tahir, Alfakih, Khaled, Andrade, Ivo, Buckingham, Susan, Bularga, Anda, Carpenter, John-Paul, Cole, Graham, Cusack, David, David, Sarojini, Davis, Patrick, Fairbairn, Timothy, Ghosh, Arjun, Ramkumar, Prasad Guntur, Hamilton, Mark, Haque, Faisal, Hudson, Benjamin, Johnstone, Annette, Karthikeyan, V.J., Kay, Mike, Khan, Mohammad Ali, Kitt, Jamie, Low, Chen Sheng, Mcalindon, Elisa, Mccreavy, David, Morrissey, Brian, Motwani, Manish, Na, Dilip, Nicol, Edward, Patel, Dilip, Rodrigues, Jonathan, Rofe, Chris, Schofield, Rebecca, Semple, Thomas, Sheikh, Azeem, Sinha, Apurva, Subedi, Deepak, Topping, William, Tweed, Katherine, Underwood, Stephen Richard, Weir-Mccall, Jonathan, Zuhairy, Hamed, Abbasi, Taimur, Abohashem, Shady, Abramson, Sandra, Al-Mallah, Mouaz, Kumar, Mohan Ashok, Balmer-Swain, Mallory, Berman, Daniel, Bernheim, Adam, Bhatti, Sabha, Biederman, Robert, Bieging, Erik, Bingham, Scott, Bloom, Stephen, Blue, Sean, Borges, Andressa, Branch, Kelley, Bravo, Paco, Buddhe, Sujatha, Budoff, Matthew, Bullock-Palmer, Renée, Cahill, Michael, Candela, Candace, Cao, Jane, Chatterjee, Saurav, Chatzizisis, Yiannis, Chaudhuri, Nita Ray, Cheezum, Michael, Chelliah, Anjali, Chen, Tiffany, Chen, Marcus, Chen, Lu, Chokshi, Aalap, Chung, Jina, Danciu, Sorin, DeSisto, William, Dilorenzo, Michael, Doukky, Rami, Duvall, William, Ferencik, Maros, Foster, Cameron, Fuisz, Anthon, Gannon, Michael, German, David, Gerson, Myron, Geske, Jeffrey, Hage, Fadi, Haider, Agha, Haider, Sofia, Hamirani, Yasmin, Hassen, Karen, Hendel, Robert, Henkel, Jacqueline, Horgan, Stephen, Hyun, Mark, Janardhanan, Rajesh, Jerome, Scott, Kalra, Dinesh, Kassop, David, Kinkhabwala, Mona, Kinzfogl, George, Koch, Bernard, Koweek, Lynne, Krepp, Joseph, Kwon, Younghoon, Layer, Jay, Lesser, John, Leung, Steve, Lisske, Bernadette, Magurany, Kathleen, Markowitz, Jeremy, Mccullough, Brenda, Moalemi, Azita, Moffitt, Chanan, Montanez, Juan, Moore, Warren, Morayati, Shamil, Mossa-Basha, Mahmud, Mrsic, Zorana, Murthy, Venkatesh, Nagpal, Prashant, Nelson, Katarina, Nijjar, Prabhjot, O’Quinn, Rupal, Passen, Edward, Patel, Toral, Patil, Pravin, Pursnani, Amit, Quachang, Nancy, Rabbat, Mark, Ranjan, Pragya, Lozano, Patricia Rodriguez, Schemmer, Mary, Seifried, Rebecca, Shah, Nishant, Shah, Amee, Shanbhag, Sujata, Sharma, Gaurav, Skotnicki, Robert, Sobczak, Michael, Soman, Prem, Sorrell, Vincent, Srichai, Monvadi, Streeter, Jim, Strickland, Leah, Suliman, Suliman, Tebyanian, Naghmeh, Thomas, Dustin, Thompson, Randall, Uretsky, Seth, Vallurupalli, Srikanth, Vandyck-Acquah, Marian, Verma, Vikas, Villines, Todd, Weinstein, Joseph, Wolinsky, David, Zareba, Karolina, Zgaljardic, Michael, Beretta, Mario, Ferrando, Rodolfo, Kapitan, Miguel, Mut, Fernando, Djuraev, Omoa, Rozikhodjaeva, Gulnora, Vera, Luisa, Duc, Binh Duong, Nguyen, Xuan Canh, Hiep Nguyen, Phuoc Minh, Hirschfeld, Cole, Choi, Andrew D., Ansheles, Alexey A., Kudo, Takashi, Bucciarelli-Ducci, Chiara, Nørgaard, Bjarne Linde, Maurovich-Horvat, Pál, Louw, Lizette, Allam, Adel H., and Narula, Jagat

Published
2022
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8. Extracorporeal Carbon Dioxide Removal to Avoid Invasive Ventilation During Exacerbations of Chronic Obstructive Pulmonary Disease: VENT-AVOID Trial – A Randomized Clinical Trial

Author

Duggal, Abhijit, primary, Conrad, Steven A., additional, Barrett, Nicholas A., additional, Saad, Mohamed, additional, Cheema, Tariq, additional, Pannu, Sonal, additional, Romero, Ramiro Saavedra, additional, Brochard, Laurent, additional, Nava, Stefano, additional, Ranieri, V. Marco, additional, May, Alexandra, additional, Brodie, Daniel, additional, Hill, Nicholas S., additional, Dumont, Tiffany, additional, Krishnan, Sudhir, additional, Exline, Matthew, additional, Paz, Francisco, additional, Huelster, Joshua, additional, Medarov, Boris, additional, Sanchez, Juan, additional, Benninghoff, Michael, additional, Barrett, Matthew, additional, Douglas, Ivor, additional, Mansoori, Jason, additional, Rackley, Craig, additional, MacIntyre, Neil, additional, Bermudez, Christian, additional, Schweickert, William, additional, King, Christopher, additional, Desai, Mehul, additional, Rovella, Jennifer, additional, Pechulis, Rita, additional, Keith Scott, L., additional, Muthiah, Muthiah P., additional, Agerstrand, Cara, additional, Abrams, Darryl, additional, Serra, Alexis, additional, Narasimham, Mangala, additional, Gottesman, Eric, additional, Levy, Mitchell, additional, Hussain, Sabiha, additional, Jagpal, Sugeet, additional, Tamae-Kakazu, Maximiliano, additional, Fitch, Stephen, additional, Criner, Gerald J., additional, Desai, Parag, additional, Faugno, Anthony, additional, Morrissey, Brian M., additional, Albertson, Timothy E., additional, Rackauskas, Mindaugas, additional, Doerschug, Kevin, additional, Sethi, Jigme, additional, Enfield, Kyle, additional, Kadl, Alexandra, additional, Akkanti, Bindu, additional, Dinh, Kha, additional, Saberi, Asif, additional, Mehta, Ashish, additional, Seethala, Raghu, additional, Blum, James, additional, Williams, Mark, additional, Buch, Ketan, additional, Pham, Si, additional, Walter, James, additional, Tillis, William, additional, Balk, Robert, additional, Jamkhana, Zafar, additional, Kaul, Pratibha, additional, Hite, Duncan, additional, Abu-Hijleh, Muhanned, additional, Siddiqui, Faisal, additional, Dill, Tracey, additional, Kinoshita, Yuki, additional, and Lund, Laura, additional

Published
2024
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9. Long-term safety and efficacy of tezacaftor–ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR (EXTEND): an open-label extension study

Author

Gibson, Ronald L., Jr., Rowe, Steven M., Lechtzin, Noah, Ahrens, Richard C., McCoy, Karen S., Aitken, Moira, Donaldson, Scott H., McBennett, Kimberly Ann, Pilewski, Joseph M., Billings, Joanne, Milla, Carlos, Rubenstein, Ronald, Rosenbluth, Daniel Brian, Linnemann, Rachel, Powers, Michael R., Fortner, Christopher, Frederick, Carla Anne, Liou, Theodore G., Black, Philip, Wang, Janice, Colombo, John L., Berdella, Maria, Indihar, Maria Veronica, Brown, Cynthia D., Anstead, Michael, Bilodeau, Lara, Sicilian, Leonard, Jain, Manu, Tolle, James Jerome, Moffett, Kathryn, Nasr, Samya, Taylor-Cousar, Jennifer, Barto, Tara Lynn, Antos, Nicholas, Rogers, John S., Quick, Bryon, Thompson, Henry R., Sawicki, Gregory, Barnett, Bruce, Zanni, Robert L., Smith, Thomas C., Schultz, Karen D., Keating, Claire, Flume, Patrick, Omlor, Gregory J., Ashare, Alix, Voter, Karen, Mehdi, Nighat, Ortiz, Maria Gabriela Tupayachi, Gardner, Tonia E., Boas, Steven R., Messore, Barbara, Zemanick, Edith, Jain, Raksha, McCarthy, Michael, Kissner, Dana G., Patel, Kapilkumar, McNamara, John, Philley, Julie, Berlinski, Ariel, Calimano, Francisco J., Chin, Terry, Conrad, Douglas, Daines, Cori, Raissy, Hengameh H., Keens, Thomas G., Lascano, Jorge E., McWilliams, Bennie, Morrissey, Brian, Reyes, Santiago, Chittivelu, Subramanyam, Hussain, Sabiha, Stone, Arvey, Wallace, James, Klingsberg, Ross, Biller, Julie A., Bui, Stephanie, Sommerburg, Olaf, Bignamini, Elisabetta, Collura, Mirella, Biner, Reta Fischer, Moller, Alexander, Salvatore, Donatello, Belleguic, Chantal, Bentur, Lea, Efrati, Ori, Kerem, Eitan, Prais, Dario, Gallego, Esther Quintana, Barry, Peter, Livnat-Levanon, Galit, Asensi, Jose Ramon Villa, Armstrong, David Stuart, de la Cruz, Oscar Asensio, Gilchrist, Francis, Tullis, Diana Elizabeth, Quon, Bradley, Lands, Larry C., Morrison, Nancy, Lavoie, Annick, Linnane, Barry, Elidemir, Okan, Ringshausen, Felix, Kappler, Matthias, Hebestreit, Helge, Mainz, Jochen, Kiefer, Alexander, Koerner-Rettberg, Cordula, Staab, Doris, Gleiber, Wolfgang, Pressler, Tacjana, Stehling, Florian, Hector, Andreas, Sutharsan, Sivagurunathan, Naehrlich, Lutz, Fischer, Rainald, Downey, Damian, Davies, Jane Carolyn, Ketchell, Robert Ian, Carroll, Mary Patricia, Doe, Simon, MacGregor, Gordon, Nash, Edward Fairbairn, Withers, Nicholas, Peckham, Daniel Gavin, Ledson, Martin James, Kansra, Sonal, Lee, Timothy William Rayner, Delaisi, Bertrand, Rault, Gilles, Le Bihan, Jean, Hubert, Dominique, Fajac, Isabelle, Sermet-Gaudelus, Isabelle, Bakker, Marleen, Arets, Bert, De Boeck, Christiane, Chiron, Raphael, Reix, Philippe, Mainguy, Catherine, van Braeckel, Eva, Malfroot, Anne, Durieu, Isabelle, Dufeu, Nadine Desmazes, Prevotat, Anne, van der Meer, Renske, Merkus, Petrus, Weersink, E.J.M., Gomez-Aguero, Isabel Barrio, Gartner, Silvia, Jover, Amparo Sole, Fernandez, Antonio Alvarez, Cox, Desmond William, McKone, Edward F., Plant, Barry James, Selvadurai, Hiranjan, Bowler, Simon David, Wainwright, Claire Elizabeth, Smith, Daniel, Middleton, Peter Gordon, Wilson, John William, Volpi, Sonia, Colombo, Carla, Fabrizzi, Benedetta, Lucidi, Vincenzina, Cresta, Federico, Cucchiara, Salvatore, Eber, Ernst, Ellemunter, Helmut, Huttegger, Isidor, Hjelte, Lena, Krantz, Christina, Gilljam, Marita, Flume, Patrick A, Downey, Damian G, Brown, Cynthia, De Boeck, Kris, Sawicki, Gregory S, Chang, Philip, Paz-Diaz, Hildegarde, Rubin, Jaime L, Yang, Yoojung, Hu, Xingdi, Pasta, David J, Millar, Stefanie J, Campbell, Daniel, Wang, Xin, Ahluwalia, Neil, Owen, Caroline A, and Wainwright, Claire E

Published
2021
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11. Acute exacerbation of idiopathic pulmonary fibrosis-a review of current and novel pharmacotherapies.

Author

Juarez, Maya M, Chan, Andrew L, Norris, Andrew G, Morrissey, Brian M, and Albertson, Timothy E

Subjects
Idiopathic pulmonary fibrosis, acute exacerbation, clinical trials, drug therapy, treatment, Autoimmune Disease, Orphan Drug, Lung, Rare Diseases, Prevention, Respiratory, Clinical Sciences
Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive form of lung disease of unknown etiology for which a paucity of therapies suggest benefit, and for which none have demonstrated improved survival. Acute exacerbation of IPF (AE-IPF) is defined as a sudden acceleration of the disease or an idiopathic acute injury superimposed on diseased lung that leads to a significant decline in lung function. An AE-IPF is associated with a mortality rate as high as 85% with mean survival periods of between 3 to 13 days. Under these circumstances, mechanical ventilation (MV) is controversial, unless used a as a bridge to lung transplantation. Judicious fluid management may be helpful. Pharmaceutical treatment regimens for AE-IPF include the use of high dose corticosteroids with or without immunosuppressive agents such as cyclosporine A (CsA), and broad spectrum antibiotics, despite the lack of convincing evidence demonstrating benefit. Newer research focuses on abnormal wound healing as a cause of fibrosis and preventing fibrosis itself through blocking growth factors and their downstream intra-cellular signaling pathways. Several novel pharmaceutical approaches are discussed.

Published
2015

14. Lutein, zeaxanthin, macular pigment, and visual function in adult cystic fibrosis patients

Author

Schupp, Christine, Olano-Martin, Estibaliz, Gerth, Christina, Morrissey, Brian M, Cross, Carroll E, and Werner, John S

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Eye Disease and Disorders of Vision, Cystic Fibrosis, Clinical Research, Rare Diseases, Lung, Macular Degeneration, Neurodegenerative, Eye, Adult, Case-Control Studies, Color Perception, Cross-Sectional Studies, Electroretinography, Female, Humans, Lutein, Male, Middle Aged, Retina, Xanthophylls, Zeaxanthins, beta Carotene, carotenoids, cystic fibrosis, lutein, zeaxanthin, macular pigment, color vision, contrast sensitivity, electroretinogram, Engineering, Medical and Health Sciences, Nutrition & Dietetics, Clinical sciences, Nutrition and dietetics
Abstract

BackgroundPancreatic insufficiency in cystic fibrosis (CF), even with replacement pancreatic enzyme therapy, is often associated with decreased carotenoid absorption. Because the macular pigment of the retina is largely derived from 2 carotenoids, lutein and zeaxanthin, the decreased serum concentrations seen in CF may have consequences for ocular and retinal healthObjectivesOur aims were to determine plasma carotenoid concentrations, determine absorption and distribution of macular pigment, and assess retinal health and visual function in CF patients.DesignIn 10 adult CF patients (ages 21-47 y) and 10 age- and sex-matched healthy control subjects, we measured macular pigment density in vivo, measured serum lutein and zeaxanthin concentrations, and comprehensively assessed visual performance (including contrast sensitivity, color discrimination, and retinal function) under conditions of daylight illumination.ResultsSerum lutein and zeaxanthin were significantly reduced (P < 0.005) in CF patients ( +/- SD: 87 +/- 36.1 and 27 +/- 15.8 nmol/L, respectively) compared with control subjects (190 +/- 72.1 and 75 +/- 23.6 nmol/L, respectively). Although macular pigment optical density was significantly lower (P < 0.0001) in the CF group (0.24 +/- 0.11) than in the control group (0.53 +/- 0.12), no significant differences in visual function were observed.ConclusionsAdults with CF have dramatically low serum and macular concentrations of carotenoids (lutein and zeaxanthin), but their ocular status and visual function are surprisingly good. The clinical implications of low plasma concentrations of carotenoids in CF are yet to be clarified.

Published
2004

15. Suppression of leukotriene B4 generation by ex-vivo neutrophils isolated from asthma patients on dietary supplementation with gammalinolenic acid-containing borage oil: possible implication in asthma.

Author

Ziboh, Vincent A, Naguwa, Stanley, Vang, Kao, Wineinger, Julie, Morrissey, Brian M, Watnik, Mitchell, and Gershwin, M Eric

Subjects
Neutrophils, Humans, Arthritis, Rheumatoid, Asthma, Hydroxyurea, Fatty Acids, Leukotriene B4, gamma-Linolenic Acid, Plant Oils, Lipoxygenase Inhibitors, Prospective Studies, Double-Blind Method, Dietary Supplements, Adult, Aged, Middle Aged, Female, Male, Arthritis, Rheumatoid, Immunology
Abstract

Dietary gammalinolenic acid (GLA), a potent inhibitor of 5-lipoxygenase (5-LOX) and suppressor of leukotriene B4 (LTB4), can attenuate the clinical course of rheumatoid arthritics, with negligible side effects. Since Zileuton, also an inhibitor of 5-LOX, attenuates asthma but with an undesirable side effect, we investigated whether dietary GLA would suppress biosynthesis of PMN-LTB4 isolated from asthma patients and attenuate asthma. Twenty-four mild-moderate asthma patients (16-75 years) were randomized to receive either 2.0 g daily GLA (borage oil) or corn oil (placebo) for 12 months. Blood drawn at 3 months intervals was used to prepare sera for fatty acid analysis, PMNs for determining phospholipid fatty acids and for LTB4 generation. Patients were monitored by daily asthma scores, pulmonary function, and exhaled NO. Ingestion of daily GLA (i) increased DGLA (GLA metabolite) in PMN-phospholipids; (ii) increased generation of PMN-15-HETrE (5-LOX metabolite of DGLA). Increased PMN-DGLA/15-HETrE paralleled the decreased PMN generation of proinflammatory LTB4. However, the suppression of PMN-LTB4 did not reveal statistically significant suppression of the asthma scores evaluated. Nonetheless, the study demonstrated dietary fatty acid modulation of endogenous inflammatory mediators without side effects and thus warrant further explorations into the roles of GLA at higher doses, leukotrienes and asthma.

Published
2004

16. Occupational Asthma

Author

Kenyon, Nicholas J., Morrissey, Brian M., Schivo, Michael, Albertson, Timothy E., Gershwin, M. Eric, editor, and Albertson, Timothy E., editor

Published
2012
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24. Organization of Outpatient Care After COVID-19 Hospitalization

Author

Valley, Thomas S., primary, Schutz, Amanda, additional, Peltan, Ithan D., additional, Vranas, Kelly C., additional, Mathews, Kusum S., additional, Jolley, Sarah E., additional, Palakshappa, Jessica A., additional, Hough, Catherine L., additional, Steingrub, Jay S., additional, Tidswell, Mark A., additional, Kozikowski, Lori-Ann, additional, Kardos, Cynthia, additional, DeSouza, Lesley, additional, Baron, Rebecca M., additional, Pinilla-Vera, Mayra, additional, Rubins, David M., additional, Arciniegas, Antonio, additional, Riker, Richard, additional, Lord, Christine, additional, Elie, Marie-Carmelle, additional, Talmor, Daniel, additional, Shapiro, Nathan, additional, Banner-Goodspeed, Valerie, additional, Hibbert, Kathryn A., additional, Brait, Kelsey, additional, Pulido, Natalie, additional, Jones, Alan, additional, Galbraith, James, additional, Nandi, Utsav, additional, Peacock, Rebekah, additional, Davis, Jenna, additional, Prekker, Matthew, additional, Puskarich, Michael, additional, Jones, Seth, additional, Roerhl, Anne, additional, Hendrickson, Audrey, additional, Matthay, Michael, additional, Kangelaris, Kirsten, additional, Liu, Kathleen, additional, Yee, Kimberly, additional, Zhuo, Hanjing, additional, Hendey, Gregory, additional, Chang, Steven, additional, Qadir, Nida, additional, Tam, Andrea, additional, Beutler, Rebecca, additional, Agarwal, Trisha, additional, Levitt, Joseph, additional, Wilson, Jennifer G., additional, Rogers, Angela, additional, Roque, Jonasel, additional, Vojnik, Rosemary, additional, Albertson, Timothy E., additional, Chenoweth, James A., additional, Adams, Jason Y., additional, Morrissey, Brian M., additional, Pearson, Skyler J., additional, Almasri, Eyad, additional, Hughes, Alyssa, additional, Moss, Marc, additional, Ginde, Adit, additional, McKeehan, Jeffrey, additional, Finck, Lani, additional, Howell, Michelle, additional, Higgins, Carrie, additional, Haukoos, Jason, additional, Gravitz, Stephanie, additional, Lyle, Carolynn, additional, Douglas, Ivor S., additional, Hiller, Terra, additional, Goold, Audrey, additional, Finigan, James, additional, Hyzy, Robert, additional, Park, Pauline, additional, Sjoding, Michael, additional, Kay, Stephen, additional, Nelson, Kristine, additional, McDonough, Kelli, additional, Jayaprakash, Namita, additional, Rivers, Emanuel P., additional, Swiderek, Jennifer, additional, Gill, Jasreen Kaur, additional, Day, Jacqueline, additional, Sherwin, Robert, additional, Wooden, James, additional, Mazzoco, Thomas, additional, Gong, Michelle Ng, additional, Aboodi, Michael, additional, Asghar, Ayesha, additional, Amosu, Omowunmi, additional, Tzehaie, Hiwet, additional, Hope, Aluko A., additional, Chen, Jen-Ting, additional, Nair, Rahul, additional, Lopez, Brenda, additional, Offor, Obiageli, additional, Mosier, Jarrod M., additional, Hypes, Cameron D., additional, Salvagio, Elizabeth, additional, Bime, Christian, additional, Cristan, Elaine, additional, Richardson, Lynne D., additional, Goel, Neha, additional, Maher, Patrick, additional, Acquah, Samuel, additional, Cardone, Donald, additional, Oldenburg, Gary, additional, Dunn, Andrew, additional, Hite, Duncan, additional, Hudock, Kristin, additional, Arroyo, Jose Gomez, additional, Roads, Tammy, additional, Duggal, Abhijit, additional, Mireles-Cabodevila, Eduardo, additional, Robinson, Bryce R.H., additional, Johnson, Nicholas J., additional, Gundel, Stephanie, additional, Evans, Laura, additional, O'Mahony, D. Shane, additional, Wallick, Julie A., additional, Pedraza, Isabel, additional, Khan, Akram, additional, Krol, Olivia, additional, Jouzestani, Milad Karami, additional, Vranas, Kelly, additional, Yealy, Donald M., additional, Angus, Derek C., additional, Weissman, Alexandra, additional, Huang, David T., additional, Boeltz-Skrtich, Aimee, additional, Moore, Steven, additional, Isenberg, Derek, additional, Files, D. Clark, additional, Miller, Chadwick, additional, Gibbs, Kevin, additional, Flores, Lori, additional, LaRose, Mary, additional, Koehler, Lauren, additional, Landreth, Leigha, additional, Morris, Peter, additional, Cassity, Evan, additional, Sturgill, Jamie, additional, Mayer, Kirby, additional, Montgomery-Yates, Ashley, additional, de Wit, Marjolein, additional, Mason, Jessica, additional, Goodwin, Andrew, additional, Grady, Abigail, additional, Burch, Patterson, additional, Enfield, Kyle B., additional, Sturek, Jeffrey M., additional, Marshall, Mary, additional, Bledsoe, Joseph R., additional, Brown, Samuel M., additional, Grissom, Colin K., additional, Armbruster, Brent, additional, Harris, Estelle, additional, Eppensteiner, John, additional, Hall, Bria Johnston, additional, Hall, Grace L., additional, McGowan, Lauren, additional, Bouffler, Andrew, additional, Walker, Erica, additional, Francis, Samuel, additional, Porter, Tedra, additional, deBoisblanc, Bennett P., additional, Lammi, Matthew R., additional, Janz, David R., additional, Lauto, Paula, additional, Romaine, Connie, additional, Sandi, Marie, additional, Rice, Todd W., additional, Self, Wesley H., additional, Ringwood, Nancy, additional, Nagrebetsky, Alexander, additional, Fitzgerald, Laura, additional, Brower, Roy G., additional, Reineck, Lora A., additional, Aggarwal, Neil R., additional, and Bienstock, Karen, additional

Published
2022
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25. Organization of Outpatient Care After COVID-19 Hospitalization

Author

Steingrub, Jay S., Tidswell, Mark A., Kozikowski, Lori-Ann, Kardos, Cynthia, DeSouza, Lesley, Baron, Rebecca M., Pinilla-Vera, Mayra, Rubins, David M., Arciniegas, Antonio, Riker, Richard, Lord, Christine, Elie, Marie-Carmelle, Talmor, Daniel, Shapiro, Nathan, Banner-Goodspeed, Valerie, Hibbert, Kathryn A., Brait, Kelsey, Pulido, Natalie, Jones, Alan, Galbraith, James, Nandi, Utsav, Peacock, Rebekah, Davis, Jenna, Prekker, Matthew, Puskarich, Michael, Jones, Seth, Roerhl, Anne, Hendrickson, Audrey, Matthay, Michael, Kangelaris, Kirsten, Liu, Kathleen, Yee, Kimberly, Zhuo, Hanjing, Hendey, Gregory, Chang, Steven, Qadir, Nida, Tam, Andrea, Beutler, Rebecca, Agarwal, Trisha, Levitt, Joseph, Wilson, Jennifer G., Rogers, Angela, Roque, Jonasel, Vojnik, Rosemary, Albertson, Timothy E., Chenoweth, James A., Adams, Jason Y., Morrissey, Brian M., Pearson, Skyler J., Almasri, Eyad, Hughes, Alyssa, Moss, Marc, Ginde, Adit, McKeehan, Jeffrey, Finck, Lani, Howell, Michelle, Higgins, Carrie, Haukoos, Jason, Gravitz, Stephanie, Lyle, Carolynn, Douglas, Ivor S., Hiller, Terra, Goold, Audrey, Finigan, James, Hyzy, Robert, Park, Pauline, Sjoding, Michael, Kay, Stephen, Nelson, Kristine, McDonough, Kelli, Jayaprakash, Namita, Rivers, Emanuel P., Swiderek, Jennifer, Gill, Jasreen Kaur, Day, Jacqueline, Sherwin, Robert, Wooden, James, Mazzoco, Thomas, Gong, Michelle Ng, Aboodi, Michael, Asghar, Ayesha, Amosu, Omowunmi, Tzehaie, Hiwet, Hope, Aluko A., Chen, Jen-Ting, Nair, Rahul, Lopez, Brenda, Offor, Obiageli, Mosier, Jarrod M., Hypes, Cameron D., Salvagio, Elizabeth, Bime, Christian, Cristan, Elaine, Richardson, Lynne D., Mathews, Kusum S., Goel, Neha, Maher, Patrick, Acquah, Samuel, Cardone, Donald, Oldenburg, Gary, Dunn, Andrew, Hite, Duncan, Hudock, Kristin, Arroyo, Jose Gomez, Roads, Tammy, Duggal, Abhijit, Mireles-Cabodevila, Eduardo, Robinson, Bryce R.H., Johnson, Nicholas J., Gundel, Stephanie, Evans, Laura, O'Mahony, D. Shane, Wallick, Julie A., Pedraza, Isabel, Hough, Catherine L., Khan, Akram, Krol, Olivia, Jouzestani, Milad Karami, Vranas, Kelly, Yealy, Donald M., Angus, Derek C., Weissman, Alexandra, Huang, David T., Boeltz-Skrtich, Aimee, Moore, Steven, Isenberg, Derek, Files, D. Clark, Miller, Chadwick, Gibbs, Kevin, Flores, Lori, LaRose, Mary, Koehler, Lauren, Landreth, Leigha, Morris, Peter, Cassity, Evan, Sturgill, Jamie, Mayer, Kirby, Montgomery-Yates, Ashley, de Wit, Marjolein, Mason, Jessica, Goodwin, Andrew, Grady, Abigail, Burch, Patterson, Enfield, Kyle B., Sturek, Jeffrey M., Marshall, Mary, Bledsoe, Joseph R., Brown, Samuel M., Peltan, Ithan D., Grissom, Colin K., Armbruster, Brent, Harris, Estelle, Eppensteiner, John, Hall, Bria Johnston, Hall, Grace L., McGowan, Lauren, Bouffler, Andrew, Walker, Erica, Francis, Samuel, Porter, Tedra, deBoisblanc, Bennett P., Lammi, Matthew R., Janz, David R., Lauto, Paula, Romaine, Connie, Sandi, Marie, Rice, Todd W., Self, Wesley H., Ringwood, Nancy, Nagrebetsky, Alexander, Fitzgerald, Laura, Brower, Roy G., Reineck, Lora A., Aggarwal, Neil R., Bienstock, Karen, Valley, Thomas S., Schutz, Amanda, Vranas, Kelly C., Jolley, Sarah E., and Palakshappa, Jessica A.

Published
2022
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26. A Randomized Clinical Trial of Antimicrobial Duration for Cystic Fibrosis Pulmonary Exacerbation Treatment

Author

Goss, Christopher H., primary, Heltshe, Sonya L., additional, West, Natalie E., additional, Skalland, Michelle, additional, Sanders, Don B., additional, Jain, Raksha, additional, Barto, Tara L., additional, Fogarty, Barbra, additional, Marshall, Bruce C., additional, VanDevanter, Donald R., additional, Flume, Patrick A., additional, Omlor, Gregory, additional, Bourne, Brenda, additional, Roberts, Dion, additional, Roberts, Vicki, additional, Nasr, Samya, additional, Kruse, Dawn, additional, Linnemann, Rachel, additional, Hailemichael, Tsion, additional, Forseen, Caralee, additional, Stapp, Heidi, additional, West, Natalie, additional, Patel, S., additional, Claudio, A., additional, Lysinger, Jerimiah, additional, Harmala, Amy, additional, Solomon, George, additional, Kersh, Latona, additional, Miller, Karen, additional, Durham, Dixie, additional, Uluer, Ahmet, additional, Fowler, Robert, additional, Frederick, Carla, additional, Caci, Nadine, additional, Teneback, Charlotte, additional, Sweet, Julie, additional, Parkins, Michael, additional, Smith, Clare, additional, Goralski, Jennifer, additional, Haywood, Kelsey, additional, Flume, Patrick, additional, Brailsford, Caroline, additional, Albon, Dana, additional, Aderholt, Christie, additional, McBennett, Kimberly, additional, Schaefer, Cindy, additional, Patel, Alpa, additional, Hunt, April, additional, Schumacher, Lauren, additional, Polenakovik, Hari, additional, Clark, Linda, additional, Nick, Jerry, additional, Poch, Katie, additional, Kissner, Dana, additional, Cahill, James, additional, Lascano, Jorge, additional, Silverman, Erin, additional, McArdle, John, additional, Champagne, Alison, additional, Vender, Robert, additional, Allwein, Lisa, additional, Cohen, Lance, additional, Barton, Norma (Jean), additional, Barto, Tara, additional, Patel, Ami, additional, Brown, Cynthia, additional, Vorhees, Nia, additional, Crosser, Michael, additional, Scott, Lawrence, additional, Ashare, Alix, additional, Rodgers, Barbara, additional, Zanni, Robert, additional, Koval, Lisa, additional, Braun, Andrew, additional, Stevens, Sophia Chiron, additional, Ortiz, Maria Tupayachi, additional, Graham, Patricia, additional, Biller, Julie, additional, Hubertz, Erin, additional, Moffett, Kathryn, additional, Clark, Tammy, additional, Griffith, Rebecca, additional, Martinez, Nancy, additional, Hussain, Sabiha, additional, Chen, Fei, additional, Egan, Marie, additional, Guzman, Catalina, additional, Wang, Janice, additional, Espinal, Aileen, additional, Walker, Patricia, additional, Kukral, Anne, additional, DiMango, Emily, additional, Francis, Sarah Fracasso, additional, Milla, Carlos, additional, Dunn, Colleen, additional, Chittivelu, Subramanyam, additional, Scott, Ashley, additional, Dorgan, Daniel, additional, Ng, Sharon, additional, Pilewski, Joseph, additional, Lanzo, Rose, additional, Chaudary, Nauman, additional, Hayden, Ryan, additional, Scofield, Steven, additional, Johnson, Barb, additional, Morrissey, Brian, additional, Robinson, Brandt, additional, Conrad, Douglas, additional, Mielke, Jenna, additional, Aitken, Moira, additional, Sanlors, Chami, additional, Nayak, Ravi, additional, Branch, Freda, additional, Rosenbluth, Daniel, additional, Siegel, Molly, additional, Ghimire, Anil, additional, Forell, Mary, additional, Daines, Cori, additional, Varela, Monica, additional, Couch, Leslie, additional, Hibbard, Rebekah, additional, Dozor, Allen, additional, Ramirez, Armando, additional, Ortega, Victor, additional, Kennedy, Kathryn, additional, Fish, David, additional, and Longtine, Karen, additional

Published
2021
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27. Upregulation of nitric oxide synthase in mice with severe hypoxia-induced pulmonary hypertension

Author

Hoedt-Miller Marloes, Morris Kenneth G, Harral Julie, Sato Koichi, Fouty Brian W, Morrissey Brian, Fagan Karen A, Vidmar Shanda, McMurtry Ivan F, and Rodman David M

Subjects
hypoxia, mice, nitric oxide (NO), nitric oxide synthase (NOS), pulmonary hypertension, Diseases of the respiratory system, RC705-779
Abstract

Abstract Background The importance of nitric oxide (NO) in hypoxic pulmonary hypertension has been demonstrated using nitric oxide synthase (NOS) knockout mice. In that model NO from endothelial NOS (eNOS) plays a central role in modulating pulmonary vascular tone and attenuating hypoxic pulmonary hypertension. However, the normal regulation of NOS expression in mice following hypoxia is uncertain. Because genetically engineered mice are often utilized in studies of NO, we conducted the present study to determine how hypoxia alters NOS expression in wild-type mice. Method Mice were exposed to sea level, ambient conditions (5280 feet) or severe altitude (17,000 feet) for 6 weeks from birth, and hemodynamics and lung NOS expression were assessed. Results Hypoxic mice developed severe pulmonary hypertension (right ventricular systolic pressure [RVsP] 60 mmHg) as compared with normoxic mice (27 mmHg). Using quantitative reverse-transcription PCR, it was found that expressions of eNOS and inducible NOS (iNOS) increased 1.5-fold and 3.5-fold, respectively, in the lung. In addition, the level of lung eNOS protein was increased, neuronal NOS (nNOS) protein was unchanged, and iNOS was below the limit of detection. Immunohistochemistry demonstrated no change in lung iNOS or nNOS staining in either central or peripheral areas, but suggested increased eNOS in the periphery following hypoxia. Conclusion In mice, hypoxia is associated with increases in lung eNOS, possibly in iNOS, but not in nNOS; this suggests that the pattern of lung NOS expression following hypoxia must be considered in studies using genetically engineered mice.

Published
2001
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29. Human Proteomics

Author

Morrissey, Brian, primary, Staunton, Lisa, additional, and Pennington, Stephen R., additional

Published
2014
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30. Long-term safety and efficacy of tezacaftor–ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR (EXTEND): an open-label extension study

Author

Flume, Patrick A, primary, Biner, Reta Fischer, additional, Downey, Damian G, additional, Brown, Cynthia, additional, Jain, Manu, additional, Fischer, Rainald, additional, De Boeck, Kris, additional, Sawicki, Gregory S, additional, Chang, Philip, additional, Paz-Diaz, Hildegarde, additional, Rubin, Jaime L, additional, Yang, Yoojung, additional, Hu, Xingdi, additional, Pasta, David J, additional, Millar, Stefanie J, additional, Campbell, Daniel, additional, Wang, Xin, additional, Ahluwalia, Neil, additional, Owen, Caroline A, additional, Wainwright, Claire E, additional, Gibson, Ronald L., additional, Rowe, Steven M., additional, Lechtzin, Noah, additional, Ahrens, Richard C., additional, McCoy, Karen S., additional, Aitken, Moira, additional, Donaldson, Scott H., additional, McBennett, Kimberly Ann, additional, Pilewski, Joseph M., additional, Billings, Joanne, additional, Milla, Carlos, additional, Rubenstein, Ronald, additional, Rosenbluth, Daniel Brian, additional, Linnemann, Rachel, additional, Powers, Michael R., additional, Fortner, Christopher, additional, Frederick, Carla Anne, additional, Liou, Theodore G., additional, Black, Philip, additional, Wang, Janice, additional, Colombo, John L., additional, Berdella, Maria, additional, Indihar, Maria Veronica, additional, Brown, Cynthia D., additional, Anstead, Michael, additional, Bilodeau, Lara, additional, Sicilian, Leonard, additional, Tolle, James Jerome, additional, Moffett, Kathryn, additional, Nasr, Samya, additional, Taylor-Cousar, Jennifer, additional, Barto, Tara Lynn, additional, Antos, Nicholas, additional, Rogers, John S., additional, Quick, Bryon, additional, Thompson, Henry R., additional, Sawicki, Gregory, additional, Barnett, Bruce, additional, Zanni, Robert L., additional, Smith, Thomas C., additional, Schultz, Karen D., additional, Keating, Claire, additional, Flume, Patrick, additional, Omlor, Gregory J., additional, Ashare, Alix, additional, Voter, Karen, additional, Mehdi, Nighat, additional, Ortiz, Maria Gabriela Tupayachi, additional, Gardner, Tonia E., additional, Boas, Steven R., additional, Messore, Barbara, additional, Zemanick, Edith, additional, Jain, Raksha, additional, McCarthy, Michael, additional, Kissner, Dana G., additional, Patel, Kapilkumar, additional, McNamara, John, additional, Philley, Julie, additional, Berlinski, Ariel, additional, Calimano, Francisco J., additional, Chin, Terry, additional, Conrad, Douglas, additional, Daines, Cori, additional, Raissy, Hengameh H., additional, Keens, Thomas G., additional, Lascano, Jorge E., additional, McWilliams, Bennie, additional, Morrissey, Brian, additional, Reyes, Santiago, additional, Chittivelu, Subramanyam, additional, Hussain, Sabiha, additional, Stone, Arvey, additional, Wallace, James, additional, Klingsberg, Ross, additional, Biller, Julie A., additional, Bui, Stephanie, additional, Sommerburg, Olaf, additional, Bignamini, Elisabetta, additional, Collura, Mirella, additional, Moller, Alexander, additional, Salvatore, Donatello, additional, Belleguic, Chantal, additional, Bentur, Lea, additional, Efrati, Ori, additional, Kerem, Eitan, additional, Prais, Dario, additional, Gallego, Esther Quintana, additional, Barry, Peter, additional, Livnat-Levanon, Galit, additional, Asensi, Jose Ramon Villa, additional, Armstrong, David Stuart, additional, de la Cruz, Oscar Asensio, additional, Gilchrist, Francis, additional, Tullis, Diana Elizabeth, additional, Quon, Bradley, additional, Lands, Larry C., additional, Morrison, Nancy, additional, Lavoie, Annick, additional, Linnane, Barry, additional, Elidemir, Okan, additional, Ringshausen, Felix, additional, Kappler, Matthias, additional, Hebestreit, Helge, additional, Mainz, Jochen, additional, Kiefer, Alexander, additional, Koerner-Rettberg, Cordula, additional, Staab, Doris, additional, Gleiber, Wolfgang, additional, Pressler, Tacjana, additional, Stehling, Florian, additional, Hector, Andreas, additional, Sutharsan, Sivagurunathan, additional, Naehrlich, Lutz, additional, Downey, Damian, additional, Davies, Jane Carolyn, additional, Ketchell, Robert Ian, additional, Carroll, Mary Patricia, additional, Doe, Simon, additional, MacGregor, Gordon, additional, Nash, Edward Fairbairn, additional, Withers, Nicholas, additional, Peckham, Daniel Gavin, additional, Ledson, Martin James, additional, Kansra, Sonal, additional, Lee, Timothy William Rayner, additional, Delaisi, Bertrand, additional, Rault, Gilles, additional, Le Bihan, Jean, additional, Hubert, Dominique, additional, Fajac, Isabelle, additional, Sermet-Gaudelus, Isabelle, additional, Bakker, Marleen, additional, Arets, Bert, additional, De Boeck, Christiane, additional, Chiron, Raphael, additional, Reix, Philippe, additional, Mainguy, Catherine, additional, van Braeckel, Eva, additional, Malfroot, Anne, additional, Durieu, Isabelle, additional, Dufeu, Nadine Desmazes, additional, Prevotat, Anne, additional, van der Meer, Renske, additional, Merkus, Petrus, additional, Weersink, E.J.M., additional, Gomez-Aguero, Isabel Barrio, additional, Gartner, Silvia, additional, Jover, Amparo Sole, additional, Fernandez, Antonio Alvarez, additional, Cox, Desmond William, additional, McKone, Edward F., additional, Plant, Barry James, additional, Selvadurai, Hiranjan, additional, Bowler, Simon David, additional, Wainwright, Claire Elizabeth, additional, Smith, Daniel, additional, Middleton, Peter Gordon, additional, Wilson, John William, additional, Volpi, Sonia, additional, Colombo, Carla, additional, Fabrizzi, Benedetta, additional, Lucidi, Vincenzina, additional, Cresta, Federico, additional, Cucchiara, Salvatore, additional, Eber, Ernst, additional, Ellemunter, Helmut, additional, Huttegger, Isidor, additional, Hjelte, Lena, additional, Krantz, Christina, additional, and Gilljam, Marita, additional

Published
2021
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31. sj-pdf-1-msc-10.1177_09691413211001405 - Supplemental material for Screening participants’ attitudes to the introduction of artificial intelligence in breast screening

Author

Vries, Clarisse F De, Morrissey, Brian E, Duggan, Donna, Staff, Roger T, and Lip, Gerald

Subjects
111708 Health and Community Services, FOS: Clinical medicine, 111402 Obstetrics and Gynaecology, FOS: Health sciences
Abstract

Supplemental material, sj-pdf-1-msc-10.1177_09691413211001405 for Screening participants’ attitudes to the introduction of artificial intelligence in breast screening by Clarisse F de Vries, Brian E Morrissey, Donna Duggan, Roger T Staff and Gerald Lip in Journal of Medical Screening

Published
2021
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32. iCAIRD – a Safe Haven model for NHS, Academia, and Industry partnership in AI

Author

Morrissey, Brian

Subjects
Computer Applications-Detection, diagnosis, Artificial Intelligence, eHealth, Technology assessment, Technical aspects, Cancer, Mammography
Abstract

Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References, Learning objectives: A shortage of breast screening radiologists is increasingly putting breast screening in the United Kingdom under significant strain [1]. The latest UK Royal College of Radiologists members census demonstrated an ongoing trend of more breast...

Published
2021
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36. Speech and taxes: balancing freedom of conscience and government speech after Johanns v. Livestock Marketing Association.

Author

Morrissey, Brian P. Jr.

Subjects
Commercial speech doctrine -- Laws, regulations and rules, Tax collection -- Laws, regulations and rules, Government information -- Laws, regulations and rules, Johanns v. Livestock Marketing Ass'n (125 S. Ct. 2055 (2005)), Government regulation, United States Constitution (U.S. Const. amend. 1), Beef Promotion and Research Act of 1985
Published
2006

43. Occupational Asthma

Author

Kenyon, Nicholas J., primary, Morrissey, Brian M., additional, Schivo, Michael, additional, and Albertson, Timothy E., additional

Published
2011
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48. Effect of Zephyr Endobronchial Valves on Dyspnea, Activity Levels, and Quality of Life at One Year. Results from a Randomized Clinical Trial

Author

Dransfield, Mark T., primary, Garner, Justin L., additional, Bhatt, Surya P., additional, Slebos, Dirk-Jan, additional, Klooster, Karin, additional, Sciurba, Frank C., additional, Shah, Pallav L., additional, Marchetti, Nathaniel T., additional, Sue, Richard D., additional, Wright, Shawn, additional, Rivas-Perez, Hiram, additional, Wiese, Tanya A., additional, Wahidi, Momen M., additional, Goulart de Oliveira, Hugo, additional, Armstrong, Brian, additional, Radhakrishnan, Sri, additional, Shargill, Narinder S., additional, Criner, Gerard J., additional, Katz, Lewis, additional, Cordova, Francis, additional, Desai, Parag, additional, Marchetti, Nathaniel, additional, Kim, Victor, additional, Shenoy, Kartik, additional, Travaline, John, additional, Thomas, Jiji, additional, Criner, Lii-Yoong H., additional, Sue, Richard, additional, Thornburg, Aaron, additional, Thomas, Terry, additional, Dransfield, Mark, additional, Bhatt, Surya, additional, Wells, James Michael, additional, Seabron-Harris, Necole, additional, Gauhar, Umair, additional, Despirito, Crissie, additional, Sciurba, Frank, additional, Bon Field, Jessica, additional, Chandra, Divay, additional, Leader, Joseph, additional, Semaan, Roy, additional, Ledezma, Christina, additional, Shah, Pallav, additional, Kemp, Samuel, additional, Garner, Justin, additional, Aboelhassan, Arafa, additional, Srikanthan, Karthi, additional, Tenda, Eric, additional, Abraham, Anita, additional, Sim, Cai, additional, Wahidi, Momen, additional, Mahmood, Kamran, additional, Shofer, Scott, additional, Coles, Kathleen, additional, de Oliveira, Hugo Goulart, additional, Oliveira, Guilherme Augusto, additional, Machado, Betina, additional, Benedetto, Igor, additional, Svartman, Fabio, additional, de Macedo Neto, Amarilio, additional, Schreiner, Leonardo, additional, Vieira, Taiane, additional, Morrissey, Brian, additional, Yoneda, Ken, additional, Tham, Tina, additional, Tompkins, Daniel, additional, Guerreiro Cardoso, Paulo F., additional, Athanazio, Rodrigo, additional, Nominando, Felipe, additional, Rached, Samia, additional, Cassimiro, Luciana, additional, Hays, Steven, additional, Seeley, Eric, additional, Shrestha, Pavan, additional, Dincheva, Gabriela R., additional, Majid, Adnan, additional, Alape-Moya, Daniel, additional, Parikh, Mihir, additional, Paton, Alichia, additional, Agnew, Alexis, additional, Pastis, Nicholas, additional, Strange, Charlie, additional, Beiko, Tatsiana, additional, Woodford, Danielle, additional, Blanton, Mary, additional, Kopas, Lisa, additional, Connolly, Timothy, additional, Santacruz, Jose Fernando, additional, Shah, Bhavin, additional, Vollenweider, Mark, additional, Herrera, Luis, additional, Khan, Rumi, additional, Sernulka, Kristine, additional, McFadden, P. Michael, additional, Barbers, Richard, additional, Hernandez, Michelle, additional, Machuzak, Michael, additional, Almeida, Francisco, additional, Cicenia, Joseph, additional, Gildea, Thomas, additional, Mehta, Atul, additional, Sethi, Sonali, additional, Meli, Yvonne, additional, Hsia, David, additional, Casaburi, Richard, additional, Stringer, William, additional, Diaz, Leticia, additional, Sung, Arthur, additional, Ramsey, Meghan, additional, Van Wert, Ryan, additional, Morris, Karen, additional, Jarad, Nabil, additional, Batchelor, Tim, additional, Sequeiros, Iara, additional, Tucker, Katy, additional, Kornaszweska, Malgorzata, additional, Fallouh, Hazem, additional, Sabit, Ramsey, additional, Naase, Hatam, additional, George, Joseph, additional, Salimian, Azin, additional, Dyer, Helen, additional, Hazelrigg, Stephen, additional, Adams, Kristal, additional, Bade, Karen, additional, Krishna, Ganesh, additional, Benn, Bryan S., additional, Canfield, Michelle, additional, Vetri Villalan, Sharmila, additional, Stewart, Travis, additional, n Slebos, Dirk-Ja, additional, ten Hacken, Nick H. T., additional, Hartman, Jorine, additional, and Augustijn, Sonja, additional

Published
2020
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50. CONTRIBUTORS

Author

Aaron, Cynthia K., primary, Akhtar, Jawaid, additional, Aks, Steven E., additional, Albertson, Timothy E., additional, Aleguas, Alfred, additional, Allison, Linda G., additional, Anderson, Angela C., additional, Arias, Juan C., additional, Baer, Alexander B., additional, Baud, Frèdèric J., additional, Baum, Carl R., additional, Belson, Martin, additional, Benitez, John G., additional, Benowitz, Neal L., additional, Betten, David P., additional, Betts, Brian Christopher, additional, Betts, Lawrence Stilwell, additional, Beuhler, Michael, additional, Bird, Steven B., additional, Blume-Odom, Carolyn M., additional, Borron, Stephen W., additional, Boyer, Edward W., additional, Bradberry, Sally M., additional, Brent, Jeffrey, additional, Brush, D. Eric, additional, Burns, Michael J., additional, Caldera, Javier R., additional, Caraccio, Thomas R., additional, Cetaruk, Edward W., additional, Chan, Andrew, additional, Chase, Peter B., additional, Cisek, James, additional, Clark, Richard F., additional, Cumpston, Kirk L., additional, Curry, Steven C., additional, Dargan,, Paul I., additional, Daubert, G. Patrick, additional, Delgado, João, additional, Dobiesz, Valerie A., additional, Donovan, J. Ward, additional, Dowsett, Robert P., additional, Dueñas-Laita, Antonio, additional, Eisenberg, Judith M., additional, Erickson, Timothy B., additional, Burns Ewald, Michele, additional, Farrell, Susan, additional, Fatovich, Tania M., additional, Fernàndez, Miguel C., additional, Fijen, J.W., additional, Foley, Chris, additional, Furbee, R. Brent, additional, Geib, Ann-Jeannette, additional, Geller, Robert J., additional, Germann, Carl A., additional, Givens, Melissa L., additional, Goans, Ronald E., additional, Goldschlager, Nora, additional, Graudins, Andis, additional, Greenberg, Michael I., additional, Guidotti, Tee L., additional, Hall, Alan H., additional, Haller, Christine A., additional, Handel, Daniel A., additional, Hantson, Philippe, additional, Hedge, Matthew W., additional, Henretig, Fred M., additional, Holland, Michael G., additional, Hovda, Knut Erik, additional, Jacobsen, Dag, additional, Jones, Alison L., additional, Juurlink, David N., additional, Kazzi, Ziad N., additional, Kenyon, Nicholas J., additional, Kerr, Fergus, additional, Keyes, Daniel C., additional, Kilbourne, Edwin M., additional, Kingston, Richard, additional, Kirk, Mark A., additional, Klein, Laura J., additional, Kleinschmidt, Kurt C., additional, Klein-Schwartz, Wendy, additional, Krenzelok, Edward P., additional, Lai, Melisa W., additional, Lapostolle, Frèdèric, additional, Lavonas, Eric J., additional, Levine, Michael, additional, Lewander, William J., additional, Liang, Ivan E., additional, Liebelt, Erica L., additional, Linakis, James G., additional, Linden, Christopher H., additional, Lynton, Richard, additional, Mannix, Rebekah C., additional, Maypole, Jack, additional, McFee, R.B., additional, McKay, Charles, additional, McNally, Jude, additional, Mégarbane, Bruno, additional, Meulenbelt, J., additional, Mirkin, Dana B., additional, Morgan, Brent W., additional, Morrissey, Brian, additional, Muller, Allison A., additional, Murphy, Nancy G., additional, Nañagas, Kristine A., additional, Nemhauser, Jeffrey B., additional, Nikkanen, Heikki Erik, additional, Olson, Kent R., additional, Osterloh, John D., additional, Palatnick, Wesley, additional, Palmer, Robert B., additional, Perez, Alberto, additional, Perry, Holly E., additional, Phillips, Scott D., additional, Pigott, David C., additional, Pinkert, Heidi, additional, Proudfoot, Alex T., additional, Prueitt, Rouhollah, additional, Quang, Lawrence S., additional, Rhee, James W., additional, Richardson, William H., additional, Rittenberger, Jon C., additional, Salhanick, Steven D., additional, Scalzo, Anthony J., additional, Schuller, Heather K., additional, Schwartz, Michael D., additional, Seger, Donna, additional, Shannon, Michael W., additional, Shrestha, Mahesh, additional, Sioris, Leo J., additional, Sivilotti, Marco L., additional, Skarbek-Borowska, Sara, additional, Smolinske, Susan C., additional, Snook, Curtis P., additional, Spoerke, David G., additional, Suchard, Jeffrey R., additional, Sue, Young-Jin, additional, Sztajnkrycer, Matthew D., additional, Ternullo, Sharon, additional, Thai, Dung, additional, Tharratt, R. Steven, additional, Thomas, Jerry D., additional, Thomas, Karen E., additional, Thundiyil, Josef G., additional, Tomassoni, Anthony J., additional, Traub, Stephen J., additional, Trestrail III, John Harris, additional, Vale, J. Allister, additional, Vena, Jason, additional, Walter, Frank G., additional, Wang, Richard Y., additional, Warfield, Sharita E., additional, Wax, Paul M., additional, White, Suzanne R., additional, Wiley, James F., additional, Williams, Saralyn R., additional, Woolf, Alan David, additional, Yarema, Mark, additional, and Yip, Luke, additional

Published
2007
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