74 results on '"Moccia D"'
Search Results
2. Dynamic Tests on a Steel Frame Equipped with Hysteretic and Visco-Re-Centring Energy Dissipating Bracing Systems
- Author
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Di Cesare, A., Ponzo, F.C., Nigro, D., and Moccia, D.
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- 2011
- Full Text
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3. Impacts of bottom trawling on benthic trophic status and meiofauna in a deep-sea sedimentary environment (Gulf of Castellammare, southwestern Mediterranean Sea)
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Pusceddu, Antonio, Paradis Vilar, Sarah, Moccia, D., Puig, Pere, Masqué, Pere, Russo, Tommaso, Meloni, Maria Carmela, Lo Iacono, Claudio, Pusceddu, Antonio, Paradis Vilar, Sarah, Moccia, D., Puig, Pere, Masqué, Pere, Russo, Tommaso, Meloni, Maria Carmela, and Lo Iacono, Claudio
- Abstract
The impacts of bottom trawling on the structure of benthic communities can be relatively nonselective, hitting biodiversity as a whole. This holds true also in the deep sea, where the impacts of trawling can be more severe and long-lasting than in shallow-waters, due to the reduced capacity for recovery and greater vulnerability of deep-sea organisms. For years, our knowledge of the impact of trawling on deep-water ecosystems has remained limited and has focused mainly on fish stocks and hard bottom systems. More recently, a number of studies have addressed the impacts of bottom trawling in the deep-sea sedimentary environments, and very few of them have focused on the impacts on meiofauna, though it is a key faunal component of deep-sea ecosystems. We investigated the impact of bottom trawling on the quantity, biochemical composition and nutritional value of sedimentary organic matter and meiofauna along the Sicilian Margin (Gulf of Castellammare, southwestern Mediterranean) at ca. 550 m depth, during the summer of 2016. Amount, biochemical composition and freshness of sedimentary OM, as well as the abundance and community composition of meiofauna were determined in sediment cores taken at both trawled and untrawled grounds. The continuous erosive processes in the trawled site have led, generally, to the depletion of OM contents (20-60% lower than those in the untrawled site), as well as to statistically significant differences from the untrawled site in its biochemical composition. Nevertheless, the upper 2 cm of the trawled site consisted of recently accumulated sediments, enriched in phytopigments, and bulk OM contents similar to those in the untrawled one, interpreted as a very recent input of fresh OM from the upper water column. The abundance of meiofauna in trawled grounds was significantly higher than that in untrawled ones, whereas no differences were observed between trawled and untrawled grounds deeper in the sediment. Differences in the meiofaunal commu
- Published
- 2020
4. Metastatic Small Cell Lung Cancer Presenting as Primary Adrenal Insufficiency
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Esperti, S., primary, Scibelli, N., additional, and Moccia, D., additional
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- 2020
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5. Organic matter contents and degradation in a highly trawled area during fresh particle inputs (Gulf of Castellammare, southwestern Mediterranean)
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Ministerio de Economía y Competitividad (España), European Commission, Generalitat de Catalunya, Australian Research Council, Ministerio de Educación, Cultura y Deporte (España), Paradis Vilar, Sarah, Pusceddu, Antonio, Masqué, Pere, Puig, Pere, Moccia, D., Russo, Tommaso, Lo Iacono, Claudio, Ministerio de Economía y Competitividad (España), European Commission, Generalitat de Catalunya, Australian Research Council, Ministerio de Educación, Cultura y Deporte (España), Paradis Vilar, Sarah, Pusceddu, Antonio, Masqué, Pere, Puig, Pere, Moccia, D., Russo, Tommaso, and Lo Iacono, Claudio
- Abstract
Bottom trawling in the deep sea is one of the main drivers of sediment resuspension, eroding the seafloor and altering the content and composition of sedimentary organic matter (OM). The physical and biogeochemical impacts of bottom trawling were studied on the continental slope of the Gulf of Castellammare, Sicily (southwestern Mediterranean), through the analysis of two triplicate sediment cores collected at trawled and untrawled sites (∼550 m water depth) during the summer of 2016. Geochemical and sedimentological parameters (excess 210Pb, excess 234Th, 137Cs, dry bulk density, and grain size), elemental (organic carbon and nitrogen) and biochemical composition of sedimentary OM (proteins, carbohydrates, lipids), as well as its freshness (phytopigments) and degradation rates were determined in both coring locations. The untrawled site had a sedimentation rate of 0.15 cm yr−1 and presented a 6 cm thick surface mixed layer that contained siltier sediment with low excess 210Pb concentrations, possibly resulting from the resuspension, posterior advection, and eventual deposition of coarser and older sediment from adjacent trawling grounds. In contrast, the trawled site was eroded and presented compacted century-old sediment highly depleted in OM components, which were between 20 % and 60 % lower than those in the untrawled site. However, the upper 2 cm of the trawled site consisted of recently accumulated sediments enriched in excess 234Th, excess 210Pb, and phytopigments, while OM contents were similar to those from the untrawled core. This fresh sediment supported protein turnover rates of 0.025 d−1, which doubled those quantified in surface sediments of the untrawled site. The enhancement of remineralization rates in surface sediment of the trawled site was associated with the arrival of fresh particles on a chronically trawled deep-sea region that is generally deprived of OM. We conclude that the detrimental effects of bottom trawling can be temporarily and parti
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- 2019
6. Surface sediment erosion and organic matter depletion induced by intense bottom trawling activities in the Gulf of Castellammare (Sicily)
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Pusceddu, Antonio, Paradis Vilar, Sarah, Masqué, Pere, Puig, Pere, Moccia, D., Cau, A., Russo, Tommaso, Lo Iacono, Claudio, and ISLAND Cruise Team
- Abstract
2018 Ocean Sciences Meeting, 11-16 February, in Portland, Oregon, Bottom trawling is a major driver of sedimentary dynamics in the deep sea, resuspending surface sediments and eroding the seafloor. Although the impacts of trawling on deep-sea sediment properties and the resulting impairment of the ecosystem functioning have been previously documented, its repercussions on the bioavailability of organic matter still need to be fully addressed. To provide insighits on this, biochemical composition of organic matter (proteins, lipids, carbohydrates, and phytopigments) along with sediment dry bulk density, grain size, and 210Pb concentrations were analyzed in triplicate sediment cores retrieved in trawled and untrawled sites from the Gulf of Castellammare, Sicily (Mediterranean Sea), during the EU Eurofleets-2 ISLAND (ExplorIng SiciLian CAnyoN Dynamics). The trawled site was severely eroded, as shown by the high dry bulk density and depleted excess 210Pb concentrations, whereas the excess 210Pb profile at the untrawled site revealed a 6 cm thick surface mixed layer derived from bioturbation overlaying softer sediments that had accumulated at an average rate of 0.15 cm yr-1. Overall, organic matter contents in the trawled site were 14-37% lower than those in the untrawled one. However, bioavailable organic matter (lipids, proteins, and phytopigments) concentrations in the uppermost layer were comparable in both trawled and untrawled sites, likely due to similar inputs of pelagic organic matter prior to the sampling period. Phytopigment concentrations decreased with depth along the cores at both sites, but at a ca. 20% higher rate in the trawled areas. This result suggests that persistent sediment resuspension and erosion due to trawling can modify food value of surficial sediments for the benthos more rapidly than biological consumption or sediment bioturbation. Then, we hypothesize that the biota in persistently trawled sediments may be more dependent upon the input from the overlaying water layers than that in untrawled sites
- Published
- 2018
7. Invasive crayfish (Procambarus clarkii, Girard, 1852) in a managed brackish wetland (Sardinia, Italy): Controlling factors and effects on sedimentary organic matter
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Palmas, F., primary, Podda, C., additional, Frau, G., additional, Cau, Al., additional, Moccia, D., additional, Peddio, S., additional, Solari, P., additional, Pusceddu, A., additional, and Sabatini, A., additional
- Published
- 2019
- Full Text
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8. Streptococcus Mitis Mediastinal Abscess in a Healthy 37 Year Old Woman
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Ohadugha, C., primary, Moccia, D., additional, Bostick, A.W., additional, and Nambudiri, V., additional
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- 2019
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9. Fragment quality and sediment organic loading regulate the survival of an invasive, clonal seaweed
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Bulleri, F, Tamburello, L, Pusceddu, A, Bonechi, L, Cau, A, Moccia, D, Gribben, PE, Bulleri, F, Tamburello, L, Pusceddu, A, Bonechi, L, Cau, A, Moccia, D, and Gribben, PE
- Abstract
Although propagule pressure is recognized as an important determinant of invasion dynamics, the role of propagule quality (i.e. the physical condition of a propagule) has received little attention. In particular, how the performance of vegetative propagules differing in quality varies across heterogeneous landscapes is yet to be explored. Caulerpa cylindracea is a clonal, invasive seaweed, widely distributed in the Mediterranean. By means of a laboratory experiment, we investigated how variation in the quality of seaweed fragments (intact vs. frond-removal vs. rhizoid-removal) influenced their survival on control versus sediments enriched with detritus from the native seagrass, Posidonia oceanica. The survival of seaweed fragments was low on non-enriched sediments, irrespective of their characteristics. On enriched sediments, survival was high in control and rhizoid-removal fragments, but low in frond-removal fragments. Our study shows that both fragment quality and sediment characteristics influence the survival of C. cylindracea propagules and, hence, long-term spreading dynamics of this seaweed. More generally, it brings novel evidence showing that the effects of propagule quality on invasion success are context-dependent.
- Published
- 2018
10. Potential impact of bottom trawling activities on sedimentary organic matter in the Gulf of Castellammare (Sicily)
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Paradis Vilar, Sarah, Pusceddu, Antonio, Masqué, Pere, Puig, Pere, Moccia, D., Cau, A., Russo, Tommaso, and Lo Iacono, Claudio
- Abstract
XXIII Congress of the Italian Association of Oceannography and Limnology, Functioning, alteration and restoration of aquatic ecosystems, 26-29 September 2017, Cagliari, Sardinia, Italy.-- XXIII Congresso della Associazione Italiana di Oceanologia e Limnologia - XXIII Congress of the Italian Association of Oceannography and Limnology, Funzionamento, alterazioni e recupero degli ecosistemi acquatici
- Published
- 2017
11. Multi-Body Approach to the Simulation of particular Drop Test for an Aircrsft Landing Gear
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DI LEO, ROMEO, DE FENZA, ANGELO, BARILE, MARCO, LECCE, LEONARDO, Moccia D., DI LEO, Romeo, DE FENZA, Angelo, Barile, Marco, Moccia, D., and Lecce, Leonardo
- Abstract
This work deals with the effectiveness of dynamic analysis for a fixed landing gear, performed through a multi-body software by providing evidence of consistency between numerical simulation and experimental drop test results for the aircraft AP.68 TP-300. After the realization of Digital Mock-up of the main components of landing gear in a C.A.D. 3D, we have imported them in ADAMS environment and we have virtually mounted them to reproduce the real constraints. In ADAMS the model of the test article has been realized too. The fuselage of aircraft and constitutive parts of landing gear have been modeled all as rigid body. Only the leaf spring and tire have been simulated as flexible body. An ADAMS Tire Model has been used in the simulation and information about the ground has been added in a Road Data file. Simulations to reproduce experimental drop test, characterized by defined weights of falling mass and height, have been developed. The results show a good correlation between numerical simulation and experimental test, which provides preliminary evidence of future possible cost reduction through a potential virtual certification of the landing gear new design development. Future development of the present activity will probably be an application of methodology to other cases for a more extensive validation of its predictive power and development of virtual certification procedure.
- Published
- 2013
12. Validation of a simplified AQUATOX model to assess quality status of a model river in Sardinia
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Salvadori Luca, Moccia Davide, Melis Laura, Folegnani Giulia, Pusceddu Antonio, Carucci Alessandra, and Ferrari Simone
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Physics ,QC1-999 - Abstract
In the framework of the periodic update of the Sardinian River Basin Management and Water Protection Plans (Italian Law 152/2006, transposition of the 2000/60/EC Directive), we investigated the AQUATOX model feasibility as a tool for assessing the relationships between Driving forces, Pressures, States, Impacts and Responses (DPSIR scheme). To do this, we applied the AQUATOX model to forecast the response of a Sardinian (Italy) river quality status to a set of different environmental perturbations, including nutrient load and water flow variations. The final aim of this work is to study a feasible model, based on a DPSIR scheme, for identifying the necessary and sustainable measures to tackle the criticalities resulting from a set of known environmental perturbations on Sardinian rivers.
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- 2022
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13. Using the AQUATOX model to forecast water bodies quality status response to environmental perturbations
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Salvadori Luca, Moccia Davide, Melis Laura, Folegnani Giulia, Pusceddu Antonio, Carucci Alessandra, and Ferrari Simone
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Physics ,QC1-999 - Abstract
In the last decades, the scientific community has developed many methods and approaches for the assessment of surface waters quality status and the relative impacts of anthropogenic pressures including, among the others, municipal and industrial wastewater treatment plants, agriculture, animal farming and many other land uses. According to the Water Framework Directive (WFD; 2000/60/EC), each EU Member State has been committed to identifying River Basin Districts, in which, ideally, every water body within European boundaries should have been included. As a contribution to the quality assessment of the Sardinian River Basin District, in the framework of the project “Hydraulic and environmental modelling for the gap analysis and the identification of programmes of measures aimed to satisfy the environmental quality objectives” funded by the Regione Sardegna, we applied a simplified version of the AQUATOX model, developed for investigating its feasibility and validity in case of missing or poor input data and information, on the river Cixerri case study.
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- 2022
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14. Supernormal contractility in primary hypertension without left ventricular hypertrophy.
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DE SIMONE, GIOVANNI, DI LORENZO, LUIGI, COSTANTINO, GUIDO, MOCCIA, DOMENICO, BUONISSIMO, SALVATORE, DE Drvrnis, ORESTE, de Simone, G, Di Lorenzo, L, Costantino, G, Moccia, D, Buonissimo, S, and de Divitiis, O
- Published
- 1988
15. Hemodynamic hypertrophied left ventricular patterns in systemic hypertension
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Oreste de Divitiis, Buonissimo S, Giovanni de Simone, Luigi Di Lorenzo, Costantino G, and Moccia D
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Adult ,Male ,medicine.medical_specialty ,Heart Ventricles ,Cardiac index ,Diastole ,Hemodynamics ,Cardiomegaly ,Muscle hypertrophy ,Reference Values ,Internal medicine ,medicine ,Humans ,Mass index ,Cardiac Output ,business.industry ,Myocardium ,Middle Aged ,Control subjects ,medicine.anatomical_structure ,Blood pressure ,Ventricle ,Hypertension ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
The hemodynamic pattern of hypertrophied left ventricle in systemic hypertension was studied by M-mode echocardiography in 42 untreated hypertensive patients with left ventricular (LV) mass index greater than 2 standard deviations from the sex-specific mean of 114 normal subjects (normal values of our laboratory), and in 45 normotensive volunteers. Hypertensive patients showed cardiac dimensions, relative diastolic wall thickness, ratio of systolic pressure to end-systolic dimension, cardiac index and stroke index greater than normotensive control subjects (0.01 less than p less than 0.0001). Pressure/dimension ratio was correlated to relative wall thickness (p less than 0.005). End-systolic stress/volume ratio was normal as was systolic pressure to dimension ratio normalized for end-diastolic wall thickness. LV hypertrophy was concentric in 26% and eccentric in 74% of patients and suggested 2 different heart adaptations to overload: eccentric hypertrophy was associated with increased cardiac dimensions, high peak stress, normal systolic function and moderately increased LV contractility; concentric hypertrophy was associated with the highest blood pressure values, normal cardiac dimension, normal peak stress, normal systolic function and much increased LV contractility. Because stress/volume ratio and wall thickness-corrected systolic pressure/dimension ratio were normal in hypertensive patients, LV contractile capacity might be supported by the increase in myocardium available for contraction, rather than by increase in inotropic state.
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- 1987
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16. Echocardiographic indexes of left ventricular contractility. Effect of load manipulation in arterial hypertension
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Giovanni de Simone, Buonissimo S, Luigi Di Lorenzo, Moccia D, and Costantino G
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medicine.medical_specialty ,business.industry ,Left ventricular contractility ,Contractility ,Endocrinology ,Blood pressure ,Linear relationship ,Afterload ,Internal medicine ,Heart rate ,medicine ,Cardiology ,cardiovascular diseases ,Derivation ,Sodium nitroprusside ,Cardiology and Cardiovascular Medicine ,business ,circulatory and respiratory physiology ,medicine.drug - Abstract
Load changes were obtained in 7 females with untreated primary hypertension by means of controlled intravenous infusion of sodium nitroprusside (0.2mg/ml), in order to assess variations in the more usual indexes of left ventricular (LV) contractility to different loads and to verify that those indexes were independent of load. 2D-controlled M-mode echocardiograms were performed at baseline and when systolic blood pressure (SBP) had been reduced by 7, 16 and 23% for at least 5min. Heart rate did not change during the test; decrease in SBP was associated with either decreases in both end-systolic dimension (LVIDs) and end-systolic stress (ESS), or an increase in systolic function. SBP/LVIDs, SBP/end-systolic volume (ESV) and ESS/LVIDs ratios were examined and compared as indexes of contractile state. SBP/ESV and ESS/LVIDs ratios showed great variation at all stages as compared to baseline values, while the SBP/LVIDs ratio did not change. The percent variation between the baseline values and the last stage of the test was 51% for the ESS/LVIDs ratio, 37% for the SBP/ESV and 5% for the SBP/LVIDs ratio. Best-fitting regression showed that a linear relationship existed only between SBP and LVIDs. Echocardiographic two-dimensional (as ESS) or three-dimensional derivations (as ESV) should be carefully employed when the contractile state is studied, while the SBP/LVIDs ratio can be easily used as a baseline value, as it is insensitive to changes in load.
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- 1988
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17. Normal Left Ventricle
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Moccia D, Buonissimo S, O. de Divitiis, G. De Simone, L. Di Lorenzo, and Costantino G
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medicine.medical_specialty ,business.industry ,Hemodynamics ,General Medicine ,Anatomy ,medicine.anatomical_structure ,Ventricle ,Ventricule gauche ,Internal medicine ,Circulatory system ,Cardiology ,Medicine ,business ,Quantitative analysis (chemistry) - Published
- 1988
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18. Supernormal contractility in primary hypertension without left ventricular hypertrophy
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O. de Divitiis, Moccia D, Buonissimo S, L. Di Lorenzo, G. De Simone, Costantino G, DE SIMONE, Giovanni, Di Lorenzo, L, Costantino, G, Moccia, D, Buonissimo, S, and de Divitiis, O.
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Adult ,Male ,Inotrope ,medicine.medical_specialty ,Systole ,Cardiac Volume ,Heart Ventricles ,Cardiomegaly ,Left ventricular hypertrophy ,Contractility ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Peak systolic pressure ,business.industry ,Fractional shortening ,Middle Aged ,medicine.disease ,Myocardial Contraction ,Blood pressure ,Echocardiography ,Hypertension ,Cardiology ,Female ,business - Abstract
Forty-three subjects with uncomplicated primary hypertension and without echocardiographic left ventricular hypertrophy and 54 normotensive volunteers were studied by two-dimensional targeted M-mode echocardiography to evaluate systolic function and contractility before the development of compensatory hypertrophy. The ratio of peak systolic pressure to end-systolic dimension was used to assess left ventricular performance and was divided for either posterior wall thickness or cross-sectional area to generate hypertrophy-independent indices of inotropic state. Fractional shortening was normal in the hypertensive group, despite the increase in end-systolic stress. Systolic pressure/dimension ratio was higher in hypertensive subjects (p less than 0.001), as were hypertrophy-independent indices of inotropic state (p less than 0.005), which were inversely correlated to left ventricular mass (p less than 0.001). Values in 11 hypertensive subjects were above the upper confidence limit of the normal shortening/stress relation, which provides a load-independent measure of inotropic state. They showed high hypertrophy-independent indices of inotropic state (p less than 0.01), while the other hypertensive subjects did not. High fractional shortening, wall stress, and systolic pressure (p less than 0.01) were found in the subgroup with supernormal performance, while left ventricular mass was not different from that of other subgroups, depicting inadequate left ventricular hypertrophy. The duration of hypertension was the same in the subgroups. Supernormal inotropic state could be considered one form of primary adaptation to high wall stress that serves to maintain systolic ventricular performance.
- Published
- 1988
19. [Echocardiographic analysis of anatomical and functional changes in the left heart ventricle during antihypertensive treatment with nicardipine]
- Author
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Costantino G, Di Lorenzo L, Buonissimo S., Moccia D, Soro S, FERRARA, LIBERATO ALDO, DE SIMONE, GIOVANNI, Costantino, G, Di Lorenzo, L, Buonissimo, S., Moccia, D, Soro, S, Ferrara, LIBERATO ALDO, and DE SIMONE, Giovanni
- Subjects
Adult ,Male ,Systole ,Hemodynamics ,Blood Pressure ,Cardiomegaly ,Heart ,Middle Aged ,Nicardipine ,Echocardiography ,Hypertension ,Drug Evaluation ,Humans ,Female - Abstract
Changes in hemodynamic variables regulating systolic function were assessed by M-mode echocardiography, under 2D control, in 11 patients with primary uncomplicated hypertension treated with nicardipine (60 mg/daily). At the end of treatment (8 weeks) blood pressure and end-systolic stress were greatly reduced (p less than 0.001), and systolic fractional shortening was increase (p less than 0.02). The percentage increase in fractional shortening was correlated with a decreased in end-systolic stress (r = 0.67). The index of left ventricular performance (systolic pressure/end-systolic dimension ratio) was reduced: no variation was found in the hypertrophy-independent index of the inotropic state (systolic pressure/end-systolic dimension ratio normalized for posterior wall thickness). No change in the inotropic state was caused by a negligible sympathetic reflex outflow: heart rate also remained unchanged. The only index of left ventricular hypertrophy which was slightly reduced after two months of treatment was left ventricular mass (p less than 0.001). In conclusion, the short-term treatment with nicardipine, in hypertensive patients, showed powerful effects in the improvement of systolic function; the possible regression of left ventricular hypertrophy must be confirmed in long-term therapy.
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- 1988
20. Analisi ecocardiografica delle variazioni anatomiche e funzionali del ventricolo sinistro in corso di trattamento antiipertensivo con nicardipina
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COSTANTINO G, DI LORENZO L, BUONISSIMO SD, MOCCIA D, SORO S, DE SIMONE, GIOVANNI, FERRARA, LIBERATO ALDO, Costantino, G, DI LORENZO, L, Buonissimo, Sd, Moccia, D, Soro, S, Ferrara, LIBERATO ALDO, and DE SIMONE, Giovanni
- Published
- 1988
21. [Hypertrophy and left ventricular function in essential arterial hypertension]
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DE SIMONE, GIOVANNI, Moccia D, Buonissimo S, Di Lorenzo L, Costantino G., DE SIMONE, Giovanni, Moccia, D, Buonissimo, S, Di Lorenzo, L, and Costantino, G.
- Subjects
Adult ,Male ,Echocardiography ,Systole ,Heart Ventricles ,Hypertension ,Humans ,Cardiomegaly ,Female ,Middle Aged ,Myocardial Contraction - Published
- 1988
22. Effects of nicardipine on left ventricular hemodynamic patterns in systemic hypertension
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S. Soro, Moccia D, Buonissimo S, L. A. Ferrara, de Simone G, Di Lorenzo L, Costantino G, DE SIMONE, Giovanni, Costantino, G, Soro, S, DI LORENZO, L, Moccia, D, Buonissimo, S, Ferrara, LIBERATO ALDO, and Di Lorenzo, L
- Subjects
Adult ,Male ,medicine.medical_specialty ,Nicardipine ,Diastole ,Concentric hypertrophy ,Blood Pressure ,Cardiomegaly ,Left ventricular hypertrophy ,Muscle hypertrophy ,Double-Blind Method ,Afterload ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Systole ,business.industry ,Middle Aged ,medicine.disease ,Myocardial Contraction ,Preload ,Echocardiography ,Hypertension ,Cardiology ,Female ,business ,medicine.drug - Abstract
To assess left ventricular (LV) functional and structural changes associated with the reduction of blood pressure (BP) values during nicardipine administration (60 mg daily, for two months), 17 hypertensive patients were studied by M-mode echocardiography, according to a double-blind design (11 with nicardipine and six with placebo). Decrease in BP induced by nicardipine was associated with decrease in myocardial afterload (end-systolic stress) (P less than .002) and improvement of systolic function (fractional shortening) (P less than .02), without changes in inotropic state (assessed by systolic BP/end-systolic dimension/posterior wall thickness ratio). At the end of trial, a 5% reduction was found in LV mass (P less than .002), whereas relative wall thickness did not change. Diastolic phase (assessed by relaxation time index, and the slope of EF tract of the anterior mitral valve leaflet) was improved (.01 less than P less than .001). Patients with concentric and eccentric hypertrophy were separately considered. Relaxation time index and fractional shortening were significantly improved only in patients with concentric hypertrophy (P less than .01), whereas in the other ones the effect of treatment was variable. These differences were probably due to different effects on preload in the two LV hemodynamic patterns. Thus, nicardipine shows powerful effects on cardiac mechanics in systemic hypertension, but these effects are different according to LV anatomic pattern. Only in the presence of concentric hypertrophy is it possible to foresee the improvement of LV function; LV hypertrophy can be also reduced in concentric hypertrophy, but in the short term the reduction is too small to assume pathophysiologic significance.
23. Analysis of N-alkylphthalimides and N,N′-polymethylene-bisphthalimides in industrial dye carrier formulations by gas chromtography—mass spectrometry
- Author
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Kovar, J., primary, Lawrence, A.H., additional, and Moccia, D., additional
- Published
- 1983
- Full Text
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24. Particulate organic matter release below melting sea ice (Terra Nova Bay, Ross Sea, Antarctica): Possible relationships with zooplankton
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Letterio Guglielmo, Claudia Ennas, Olga Mangoni, Antonio Pusceddu, Antonia Granata, Alessandro Cau, Davide Moccia, Francesco Bolinesi, Kerrie M. Swadling, Maria Saggiomo, Cau, A., Ennas, C., Moccia, D., Mangoni, O., Bolinesi, F., Saggiomo, M., Granata, A., Guglielmo, L., Swadling, K. M., and Pusceddu, A.
- Subjects
0106 biological sciences ,Sea ice ,Antarctic sea ice ,Trophic webs ,Aquatic Science ,Oceanography ,010603 evolutionary biology ,01 natural sciences ,Zooplankton ,Terra Nova Bay ,Water column ,POM fluxes ,Phytoplankton ,14. Life underwater ,Clione limacina antarctica ,Limacina helicina antarctica ,Ecology, Evolution, Behavior and Systematics ,geography ,geography.geographical_feature_category ,biology ,010604 marine biology & hydrobiology ,Antarctica ,fungi ,Global warming ,Clione limacina ,biology.organism_classification ,13. Climate action ,Environmental science ,Bay ,POM fluxe - Abstract
Timing and rates of release of particulate organic matter (POM) beneath the Antarctic sea ice during the melting season are relatively unknown. To shed light on this topic, we investigated: i) quantity and biochemical composition of POM released below annual sea ice in Terra Nova Bay (TNB, Ross Sea, Antarctica) through sediment traps deployed at 10- and 30-m depth; ii) the abundance and taxonomic composition of phytoplankton; iii) the abundance and biochemical composition of two zooplankton species, namely the pteropods Clione limacina antarctica and Limacina helicina antarctica. Overall, our results show that in late spring-early summer in TNB the melting of annual sea ice determines a rapid release of particles into the underlying water column, and that those particles are transported downward at the rate of hours to days. POM fluxes were dominated by lipids, which probably resulted from zooplankton grazing activity on sea-ice algae and faecal pellets that were released into the water column. This, after the initial injection of particles, which were likely associated with sinking sympagic microalgal biomass derived from the sea ice melting, enhanced the nutritional value of POM. POM released beneath the sea ice, in turn, had a possible effect on the biochemical composition of the two pteropod species. Our results confirm that melting of sea ice in spring-summer each year in Antarctic coastal waters represents a fundamental step in the transfer of energy towards the higher trophic levels. Evidence of a decline in Antarctic sea ice over the last five years, plausibly as a consequence of global warming, underlines a conspicuous decline in habitat availability for sea-ice algae and, as a consequence, a drop in the availability of food for pteropods and the higher trophic levels of the coastal Antarctic Ocean.
- Published
- 2021
25. Concepire la governance urbana in ottica di servizio efficiente
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De Falco S, Ammaturo F, MOCCIA D., SEPE M., De Falco, S, and Ammaturo, F
- Published
- 2017
26. Le università nella geografia della competizione per l’innovazione territoriale
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De Falco S, MOCCIA D., SEPE M., and De Falco, S
- Published
- 2017
27. La Città Metropolitana di Palermo
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LO PICCOLO, Francesco, LOTTA, Francesca, SCHILLECI, Filippo, De Luca, G, Moccia, D, Lo Piccolo, F, Lotta, F, and Schilleci, F
- Subjects
Città Metropolitana ,Sicilia ,Settore ICAR/21 - Urbanistica ,Palermo - Abstract
L’attuale dibattito sul tema della Città Metropolitana in Italia, già vivo dagli anni sessanta in stretta relazione con i temi della città regione e della pianificazione regionale e in maniera istituzionale dagli anni novanta del XX secolo, trova un rinnovato interesse alla fine del 2013 quando si dibatte sull’opportunità di sopprimere l’istituto delle province e di riorganizzare la struttura amministrativa degli enti locali, ridefinendo compiti e responsabilità. Tutto ciò trova una sua codificazione circa un anno fa quando la L.n. 56/2014 converte il ddl Delrio dettando precise disposizioni legislative sulle città metropolitane, sulle province e sulle unioni e fusioni di comuni. Le conseguenze di tale legge sono state molto differenti secondo i contesti geografici e politici, in particolar modo in quelle regioni a statuto speciale che hanno potestà legislativa autonoma. La Sicilia, nello specifico, ha iniziato un iter di recepimento, e trasformazione in legge propria, dei contenuti della legge suddetta, senza peraltro a oggi essere arrivati a una definizione precisa e compiendo passi avanti e passi indietro, e talvolta anche laterali, quasi a volere compiere un percorso circolare per tornare al punto di partenza. Il contributo vuole offrire un quadro attuale dei processi che sono seguiti a tali disposizioni legislative, prendendo come caso studio la città di Palermo.
- Published
- 2017
28. Between Identity and New Tracks: the Project of the River Landscape
- Author
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Gioffre' Vincenzo, De Giacomo Nathalie, Petrocelli E. Moccia D., Gioffre', Vincenzo, and De Giacomo, Nathalie
- Published
- 2016
29. River landscape transformation in Campania Region: representative cases of the Sarno and the Volturno Rivers
- Author
-
Palmentieri, Stefania, Ronza, Maria, Delle Donne, Barbara, Petroncelli E., Moccia D., Palmentieri, Stefania, Ronza, Maria, and Delle Donne, Barbara
- Subjects
Paesaggio fluviale, inquinamento, sviluppo - Abstract
La particolare fragilità degli ecosistemi fluviali rispetto ai radicali processi di antropizzazione che hanno investito la Campania già a partire dalla metà del secolo scorso, rappresenta uno dei principali interessi di studio per i geografi che si occupano di rischio ambientale, pianificazione e paesaggio. Il contributo prende in esame i territori del fiume Sarno e del Volturno per individuare, anche attraverso la chiave di lettura del paesaggio, strategie di riqualificazione ambientale, pianificazione e contrasto del rischio e sviluppo sostenibile.
- Published
- 2016
30. Palermo
- Author
-
LOTTA, Francesca, Moccia, D, De Luca G., and Lotta, F.
- Subjects
città metropolitana ,confini ,riforme ,Settore ICAR/21 - Urbanistica - Abstract
“Immagini di territori metropolitani” rappresenta una raccolta che anticipa una riflessione più organica e interpretativa sulle 14 Città metropolitane italiane. Palermo è una di queste e il testo mette in evidenza l'intero e complesso processo che ha portato all'attuale asseto amministrativo del territorio metropolitano.
- Published
- 2015
31. Spazi di ‘soglia’ e diritto alla cittadinanza: esperienze e riflessioni per la riconquista dello spazio pubblico
- Author
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BONAFEDE, Giulia, LO PICCOLO, Francesco, Moccia, D, Bonafede, G, and Lo Piccolo, F
- Subjects
Spazio pubblico, cittadinanza, partecipazione, H. Arendt ,Spazio pubblico ,partecipazione ,H. Arendt ,Settore ICAR/21 - Urbanistica ,cittadinanza - Abstract
Nell’Europa contemporanea si registra un’ampia varietà di comunità culturali. Alcune di queste comunità possono, naturalmente, essere costruite su valori e modi di vita che sono così antisociali da renderli immeritevoli di supporto e tolleranza, ma – in ogni caso e come dato di fatto – la società contemporanea è divisa in un arcipelago frammentato di differenti minoranze e gruppi plurali. Riteniamo questi gruppi come socialmente costruiti – cioè come fenomeni sociali dinamici i cui confini si spostano nel tempo, e la cui rilevanza nella vita dei membri e in quella di coloro che non ne fanno parte varia nel tempo e nello spazio: questa visione è emersa all'interno del dibattito sui nuovi movimenti sociali, evidenziando il ruolo degli aspetti sociali e culturali nei cambiamenti collettivi (Melucci, 1989; Giddens, 1991). Con riferimento alla loro dimensione spaziale, questi gruppi possono essere comunità emarginate o segregate e, in alcuni casi, appaiono come “gated communities”. Confini materiali e immateriali creano la divisione spaziale, sociale e culturale tra i gruppi. Allo stesso tempo, i confini sono alla base della divisione tra sfera pubblica e privata che è anche una separazione tra spazi pubblici e privati. Tra la sfera pubblica e quella privata esiste (potenzialmente) una zona di “soglia” delle reti sociali e delle azioni comunitarie. Nuove forme di costruzione di “spazi comuni” (materiali e immateriali) aumentano nelle frange più marginali della città come pratiche innovative del vivere e lavorare insieme. Con questo contributo intendiamo esplorare la questione delle aree “soglia” nella sua doppia interpretazione: 1. come luoghi fisici, dove gruppi marginali o esclusi sono costretti a sperimentare azioni collettive per ottenere migliori condizioni di vita (urbane); 2. come metafora di un infra-spazio tra sfera pubblica e privata, che è anche precondizione per l'esistenza dello spazio pubblico della democrazia. In tale approccio, la sostanziale precondizione per qualsiasi forma di democrazia è l'esistenza di spazi politici come l’idea di Arendt di un "infra-spazio" tra pari che discutono e agiscono liberamente. Così, lo spazio pubblico della democrazia coincide con lo spazio politico della libertà. Dove lo spazio tangibile dell'Agorà e quello metaforico della democrazia non esistono, non c’è spazio politico (Arendt, 1958). In termini di pianificazione non esiste uno spazio (in termini anche di efficacia) per i processi di pianificazione partecipativa. Al fine di illustrare le nostre considerazioni su questo tema, useremo alcuni concetti sviluppati da Hannah Arendt (1958), applicandoli al discorso politico nella pianificazione di processi partecipativi. Questo ci porta a considerare e soppesare alcune ambiguità e retoriche che compongono il concetto di pratiche partecipative inclusive, e di individuare alcune precondizioni inevitabili al fine di costruire efficienti processi di pianificazione partecipativa, considerando che l'interesse pubblico e la costruzione del consenso ricevono bassa priorità politica. There is, in contemporary Europe, a wide variety of cultural communities. Some of these cultural communities may, of course, be built around values and ways of life, which are so anti-social as to make them unworthy of toleration or support, but – in any case and as a matter of fact – contemporary society is divided into a fragmented and diversified archipelago of minority and plural groups. We view these groups as socially constructed – i.e. as dynamic social phenomena whose boundaries shift over time, and whose salience in the lives of members and non-members varies over time and place: this view emerged within the debate on new social movements, highlighting the role of social and cultural elements in social changes (Melucci, 1989; Giddens, 1991). In reference to their spatial dimension, these groups can be marginalised or segregated communities, and in some cases they appear as ‘gated’ communities. Material and immaterial boundaries create the spatial, social and cultural division between groups. At the same time, boundaries are at the base of the division between private and public spheres that is also between public and private spaces. Between the private and the public sphere, a ‘threshold’ area of social networks’ and community actions does (potentially) exist. New forms of construction of (material and immaterial) ‘common spaces’ rise in the most marginal fringes of the city, as innovative practices of ‘work and live’ together. In this paper we would like to explore the issue of the ‘threshold areas’ in its double interpretation: 1. as physical places where marginal or excluded groups are forced to experiment collective actions in order to gain better (urban) life conditions; 2. as metaphor of an infra-space between private and public sphere, which is also as a pre-condition for the existence of the public space of democracy. In this approach, the substantial precondition for any form of democracy is the existence of political spaces such as the Arendt’s idea of a discursive and acting “infra-space” among equal individuals freely debating. Thus, the public space of democracy coincides with the political space of freedom. Where the tangible space of the agora and the metaphorical space of democracy do not exist, there is no political space (Arendt, 1958). In planning terms, there is no space (that is also efficacy) for participative planning processes. In order to illustrate our considerations on this issue, we will use some concepts as developed by Hannah Arendt (1958), applying them to the political discourse in planning participatory processes. This leads us to consider and weigh up some of the rhetoric and ambiguities making up the concept of inclusionary participative practices, as well as individuating some unavoidable preconditions in order to build up efficient participative planning processes, whereas public interest and consensus building receive low policy priority.
- Published
- 2010
32. L’urbanistica della riqualificazione: il ruolo dei Sit
- Author
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ORLANDO, Marilena, MOCCIA D., and ORLANDO M
- Published
- 2008
33. Lazio: distretti alla prova
- Author
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CREMASCHI, Marco, ELISEI P, LUCCIARINI S., F. MOCCIA, D. DE LEO, Cremaschi, Marco, Elisei, P, and Lucciarini, S.
- Published
- 2007
34. Diffusione urbana e multietnicità al Sud. Strategie di integrazione e forme del progetto urbanistico
- Author
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Guida G, AA.VV., Moccia D, Sepe M, and Guida, G
- Published
- 2005
35. Introduzione. Immagini dello sviluppo e scenari del cambiamento regionale in Campania
- Author
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BELLI, ATTILIO, MOCCIA D., COPPOLA E., and Belli, Attilio
- Published
- 2005
36. Centri Storici: contesti in trasformazione tra tendenze e processi di riqualificazione
- Author
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PROCENTESE, FORTUNA, Moccia D., Procentese F., Toscano D. Sepe M., and Procentese, Fortuna
- Abstract
Il contributo riporta il lavoro di ricerca svolto nei centri storici di Caserta al fine di rilevare la percezione dei luoghi e la potenziale riqualificazione economica e sociale.
- Published
- 2005
37. LA COSTRUZIONE DEL PAESAGGIO E I NUOVI SOGGETTI DELLA PIANIFICAZIONE DI AREA VASTA
- Author
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VIGNOZZI, ALESSANDRO, F. D. Moccia, D. De Leo, and Vignozzi, Alessandro
- Subjects
processi decisionali ,metodi di pianificazione ,paesaggio urbano e rurale - Abstract
A partire dalle formulazioni della Convenzione Europea sul Paesaggio, se ne discute lo stato di avanzamento in termini di pratiche reali e le difficoltà di applicazione in relazione alla crescente complessità delle procedure e del quadro degli attori coinvolti.
- Published
- 2003
38. Microplastics impair extracellular enzymatic activities and organic matter cycling in oligotrophic sandy marine sediments.
- Author
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Cau A, Moccia D, Dessì C, Carugati L, Carreras-Colom E, Atzori F, Cadoni N, and Pusceddu A
- Subjects
- Environmental Monitoring, Ecosystem, Geologic Sediments chemistry, Water Pollutants, Chemical analysis, Microplastics
- Abstract
Microplastics (MPs) are ubiquitous and constantly accumulating in the marine environment, especially sediments. Yet, it is not well clarified if and how their carbon backbone could interact with surrounding sediments, eventually impairing key benthic processes. We assessed the effects of a 'pulse' contamination event of MPs on sedimentary organic matter (OM) quantity, quality and extracellular enzymatic activities (EEAs), which are well established descriptors of benthic ecosystem functioning. Marine sediments were exposed for 30 days to environmentally relevant concentrations (∼0.2 % in weight) of naturally weathered particles (size range 70-210 μm) of polyurethane, polyethylene, and a mixture of the most common polymers that are documented to accumulate in marine sediments. Despite the low concentration, contaminated sediments showed significantly different composition of OM, showing a decrease in lipid content and increase in protein. Moreover, we document a significant decrease (over 25 %) in quantity of biopolymeric C already after 15 days of exposure, compared to controls. Contaminated sediments showed lower C degradation rates (up to -40 %) and altered EEAs, with alkaline phosphatase being ∼50 % enhanced and aminopeptidase being reduced over 35 % compared to control treatments. Overall, the effects generated by the mixture of polymers were smaller than those exerted by the same amount of a single polymer. Our results provide insights on how that MPs can significantly alter marine sedimentary biogeochemistry through altered benthic processes, that could cumulatively impair whole benthic trophic webs by enhancing the accumulation and possible longer-term storage of recalcitrant organic C in the seabed., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
39. Comparative microplastic load in two decapod crustaceans Palinurus elephas (Fabricius, 1787) and Nephrops norvegicus (Linnaeus, 1758).
- Author
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Cau A, Gorule PA, Bellodi A, Carreras-Colom E, Moccia D, Pittura L, Regoli F, and Follesa MC
- Subjects
- Animals, Microplastics, Plastics, Nephropidae, Environmental Monitoring methods, Palinuridae, Water Pollutants, Chemical analysis
- Abstract
The present work compares microplastics (MPs) contamination in two charismatic crustaceans: European spiny lobster Palinurus elephas and langoustine Nephrops norvegicus. Samples (P. elephas n = 14; N. norvegicus n = 15) were collected between 76 and 592 m depth, from four sites in west Sardinia, Italy. An extraction protocol was applied on stomachs and intestines, separately, and over 500 particles were further characterized through μFT-IR. We document 100 % occurrence in specimens from both species, with P. elephas being significantly more contaminated (9.1 ± 1.75 vs. 3.2 ± 0.45 MPs individual
-1 ), ingesting larger MPs with different polymeric composition. The scavenging-based feeding strategy of both species could explain such exposure to MPs, mostly derived by single-use plastic. The overall results highlight that both species are clearly affected by plastic pollution, being valuable bioindicators and charismatic species that could thus represent excellent flagship species for raising awareness toward the global issue of plastic in the marine environment., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)- Published
- 2023
- Full Text
- View/download PDF
40. Effects of Field Simulated Marine Heatwaves on Sedimentary Organic Matter Quantity, Biochemical Composition, and Degradation Rates.
- Author
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Soru S, Stipcich P, Ceccherelli G, Ennas C, Moccia D, and Pusceddu A
- Abstract
Since rising temperature (T) will enhance biochemical reactions and coastal marine sediments are hotspots of carbon cycling, marine heatwaves' (MHWs') intensification caused by climate change will affect coastal biogeochemistry. We investigated the effects of MHWs on sediment organic matter (OM) in a nearshore locality (NW Sardinia, Mediterranean Sea) receiving an artificial warm water plume generating T anomalies of 1.5-5.0 °C. Sediments were collected before and after 3 and 11 weeks from the initial plume release. Both MHWs influenced sedimentary OM quantity, composition, and degradation rates, with major effects associated with the highest T anomaly after 3 weeks. Both MHWs enhanced sedimentary OM contents, with larger effects associated with the highest T anomaly. Phytopigment contents increased in the short term but dropped to initial levels after 11 weeks, suggesting the occurrence of thermal adaptation or stress of microphytobenthos. In the longer term we observed a decrease in the nutritional quality of OM and a slowdown of its turnover mediated by extracellular enzymes, suggestive of a decreased ecosystem functioning. We anticipate that intensification of MHWs will affect benthic communities not only through direct effects on species tolerance but also by altering benthic biogeochemistry and the efficiency of energy transfer towards higher trophic levels.
- Published
- 2022
- Full Text
- View/download PDF
41. Environmental Status and Geomorphological Characterisation of Seven Black Coral Forests on the Sardinian Continental Shelf (NW Mediterranean Sea).
- Author
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Moccia D, Carugati L, Follesa MC, Cannas R, Carbonara P, Pusceddu A, and Cau A
- Abstract
Marine animal forests are key mesophotic ecosystems that are under threat from increasing natural and human pressures. Despite the fact that various international agreements strive to preserve these fragile ecosystems, the environmental status of the majority of these animal-structured environments is unknown. Assessing their environmental status is the first step needed to monitor these essential habitats' health over time and include them within conservation and protection frameworks, such as the Marine Strategy Framework Directive. Based on Multibeam data and ROV footage, we characterized the geomorphological setting and evaluated the environmental status of seven black coral forests in the centre of the Western Mediterranean Sea, using the Mesophotic Assemblages Conservation Status (MACS) Index. The presence of two antipatharians, Antipathella subpinnata and Leiopathes glaberrima , characterized the seven investigated sites, dwelling on rocky substrate characterized by different environmental drivers (i.e., depth, slope of the substrate, terrain ruggedness, topographic positioning index, and aspect). From the combined evaluation of the associated benthic community status and the anthropogenic impacts affecting it, a "high" and "good" environmental status was assessed for five out of the seven studied black forests, with only two forests classified as having a "moderate" and "poor" status, respectively. Overall, our study showed a site-specific variability of mesophotic black coral forest status, explained by different biological community structures and environmental conditions mainly associated with morphological and anthropogenic factors.
- Published
- 2022
- Full Text
- View/download PDF
42. Deep-Dwelling Populations of Mediterranean Corallium rubrum and Eunicella cavolini : Distribution, Demography, and Co-Occurrence.
- Author
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Carugati L, Moccia D, Bramanti L, Cannas R, Follesa MC, Salvadori S, and Cau A
- Abstract
Corallium rubrum and Eunicella cavolini are two octocorals, reported as co-occurring species in the deep rocky habitats of the Mediterranean Sea with a high hydrodynamic and moderate eutrophication. Their spatial distribution and demography in the deep sea are mainly affected by temperature and direct and indirect anthropogenic activities; however, knowledge of the factors that potentially influence their co-existence is scarce. This paper provides novel data on the distribution and demography of these two species, at depths between 50 and 290 m in the Western Mediterranean Sea, providing insights on their co-occurrence. Both species exhibited the highest population density at deeper sites (>150 m), showing an inverse size-density relation. Density values ranged from 0.03 colonies m
-2 to 32 and 80 col. m-2 for yellow gorgonian and red coral, respectively. The two species co-occurred in 13% of the total frames examined, mostly dwelling between 120 and 160 m depth. Distance-based linear modeling (DistLM) emphasized that when co-occurring the variability of the two species' densities were significantly driven by the density-rather than the morphology (i.e., height)-of the other species. We stress the need for further studies to elucidate the possible mutual effects of suspension feeders and to test the role of different environmental factors potentially influencing inter-specific relationships.- Published
- 2022
- Full Text
- View/download PDF
43. Scattered accumulation hotspots of macro-litter on the seafloor: Insights for mitigation actions.
- Author
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Cau A, Franceschini S, Moccia D, Gorule PA, Agus B, Bellodi A, Cannas R, Carugati L, Cuccu D, Dessì C, Marongiu MF, Melis R, Mulas A, Porceddu R, Porcu C, Russo T, and Follesa MC
- Subjects
- Glass, Mediterranean Sea, Metals, Rubber, Waste Products analysis, Environmental Monitoring, Plastics
- Abstract
Marine litter is an ever-increasing problem that demands immediate reduction plans and mitigation actions that should act synergically to efficiently meet ambitious goals. Since the seafloor has been recognized as the major sink for marine debris, the study of litter accumulation dynamics represent a fundamental tool to evaluate possible removal actions. We analysed a 7 years (2013-2019) standardized data series collected along Sardinian fishing grounds through MEDiterranean International Trawl Survey, for which estimates of density and weight of seafloor macro-litter were calculated for over 707 hauls. Results show the absence of any temporal trend in seafloor macro-litter density and weight, but rather indicate a spatial and bathymetric segregation of different litter categories. Our data showed how different sources and physical features of macro-litter items (i.e., plastic and fishing gear, rubber, glass, metals, and cloth) led to spatially segregated accumulation hotspots. We also point out here how the identification of seafloor macro-litter hotspots using aggregated data that include plastic items could obscure the identification of other segregated but yet relevant hotspots of other macro-litter categories accumulated in the marine environment. These hotspots often occurred at shallower depths and closer to coastlines, thus representing potential spots where eventual future litter removal action could be prioritized., (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
44. An uncommon unilateral primary T cell adrenal lymphoma: A case report.
- Author
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Gosal K, Barr M, Moccia D, and Patel P
- Abstract
Primary adrenal lymphoma (PAL) is a rare disease with rapid progression. We present a case of PAL with T cell lymphoma in an 81-year-old male who initially presented with altered mental status and extreme weight loss. It is important to consider PAL in patients found to have adrenal masses to allow for prompt diagnosis and initiation of treatment., Competing Interests: The authors declare no conflict of interest., (© 2021 The Authors.)
- Published
- 2021
- Full Text
- View/download PDF
45. Scattered accumulation hotspots of macro-litter on the seafloor: Insights for mitigation actions.
- Author
-
Cau A, Franceschini S, Moccia D, Gorule PA, Agus B, Bellodi A, Cannas R, Carugati L, Cuccu D, Dessì C, Marongiu MF, Melis R, Mulas A, Porceddu R, Porcu C, Russo T, and Follesa MC
- Abstract
Marine litter is an ever-increasing problem that demands immediate reduction plans and mitigation actions that should act synergically to efficiently meet ambitious goals. Since the seafloor has been recognized as the major sink for marine debris, the study of litter accumulation dynamics represents a fundamental tool to evaluate future removal actions. We analysed a 7 years (2013-2019) standardized data series collected along Sardinian fishing grounds through MEDiterranean International Trawl Survey, for which estimates of density and weight of seafloor macro-litter were calculated over 707 hauls. Results show the absence of any temporal trend in seafloor macro-litter density and weight, but rather indicate a spatial and bathymetric segregation of different litter categories. Our data showed how different sources and physical features of macro-litter items (i.e., plastic and fishing gears, rubber, glass, metal and textile) led to spatially segregated accumulation hotspots. These hotspots often occurred at shallower depths and closer to coastlines, representing spots where future litter removal action could be prioritized. We also point out here how the identification of seafloor macro-litter hotspots using aggregated data that include plastic items could indeed hide the identification of hotspots of other less abundant but yet detrimental macro-litter categories accumulated in the marine environment., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021. Published by Elsevier Ltd.)
- Published
- 2021
- Full Text
- View/download PDF
46. Foraging of the sea urchin Paracentrotus lividus (Lamarck, 1816) on invasive allochthonous and autochthonous algae.
- Author
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Pusceddu A, Mikhno M, Giglioli A, Secci M, Pasquini V, Moccia D, and Addis P
- Subjects
- Animals, Introduced Species, Caulerpa, Paracentrotus, Seaweed
- Abstract
Attempts to control marine invasive alien species (IAS) with native predators gained contrasting results, so far. To explore the feasibility of this approach to control the invasive marine alga Caulerpa cylindracea, we investigated the foraging behaviour of the sea urchin Paracentrotus lividus on three native macroalgae (Ulva sp., Penicillus capitatus and Cystoseira compressa) and on C. cylindracea. The consumption rate of C. cylindracea fresh biomass resulted larger than that of the other algae, when offered separately or in combination. C. cylindracea, however, was not the most attractive food item. The larger consumption rates of C. cylindracea can be explained by its specific caloric content (as assessed by its biochemical composition) that is lower than that of the other algae. Our results confirm that P. lividus can feed on C. cylindracea, but do not fully support its use to control C. cylindracea, unless in conditions where this alga is largely dominant because of other factors., (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
47. Acute Plasma Cell Leukemia Presenting as Primary Hyperammonemic Encephalopathy.
- Author
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Patel D, Mangano A, Moccia D, Esperti S, Udani K, Henderson J, and Balanchivadze N
- Abstract
Primary plasma cell leukemia (PPCL) is a rare form of multiple myeloma (MM) and is a rare aggressive disease with a median overall survival of 6 - 11 months. We present a case of acute hyperammonemic encephalopathy as the initial presentation of PPCL in a 78-year-old woman to highlight an atypical presentation of this disorder., Competing Interests: None to declare., (Copyright 2020, Patel et al.)
- Published
- 2020
- Full Text
- View/download PDF
48. Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding.
- Author
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McCloskey K, Sigel EA, Kearnes S, Xue L, Tian X, Moccia D, Gikunju D, Bazzaz S, Chan B, Clark MA, Cuozzo JW, Guié MA, Guilinger JP, Huguet C, Hupp CD, Keefe AD, Mulhern CJ, Zhang Y, and Riley P
- Subjects
- Epoxide Hydrolases antagonists & inhibitors, Estrogen Receptor alpha antagonists & inhibitors, Ligands, Protein Kinase Inhibitors chemistry, Proto-Oncogene Proteins c-kit antagonists & inhibitors, DNA chemistry, Drug Discovery methods, Neural Networks, Computer, Small Molecule Libraries chemistry
- Abstract
DNA-encoded small molecule libraries (DELs) have enabled discovery of novel inhibitors for many distinct protein targets of therapeutic value. We demonstrate a new approach applying machine learning to DEL selection data by identifying active molecules from large libraries of commercial and easily synthesizable compounds. We train models using only DEL selection data and apply automated or automatable filters to the predictions. We perform a large prospective study (∼2000 compounds) across three diverse protein targets: sEH (a hydrolase), ERα (a nuclear receptor), and c-KIT (a kinase). The approach is effective, with an overall hit rate of ∼30% at 30 μM and discovery of potent compounds (IC
50 < 10 nM) for every target. The system makes useful predictions even for molecules dissimilar to the original DEL, and the compounds identified are diverse, predominantly drug-like, and different from known ligands. This work demonstrates a powerful new approach to hit-finding.- Published
- 2020
- Full Text
- View/download PDF
49. Benthic Crustacean Digestion Can Modulate the Environmental Fate of Microplastics in the Deep Sea.
- Author
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Cau A, Avio CG, Dessì C, Moccia D, Pusceddu A, Regoli F, Cannas R, and Follesa MC
- Subjects
- Animals, Environmental Monitoring, Microplastics, Norway, Plastics, Water Pollutants, Chemical analysis
- Abstract
Microplastics (MPs) are ubiquitous contaminants of the marine environment, and the deep seafloor is their ultimate sink compartment. Manipulative and field experiments provided evidence of the ingestion of MPs by deep-sea fauna, but knowledge of MPs' fate once ingested still remains scant. We provide evidence of MP partial retention and fragmentation mediated by digestion activity of a Norwegian langoustine, a good bioindicator for MP contamination of the deep sea. We report here that MPs in the intestines were more abundant and significantly smaller (up to 1 order of magnitude in surface) than those in the stomachs. Our results show that the stomach can act as a size-bottleneck for ingested MPs, enhancing the retention of larger particles within the stomach and promoting fragmentation into smaller plastic debris, which is then released in the intestine. Our results provide evidence that the langoustine is responsible for the fragmentation of MPs already accumulated in sediments through its scavenging activity and digestion. These findings highlight the existence of a new peculiar kind of "secondary" MPs, introduced in the environment by biological activities, which could represent a significant pathway of plastic degradation in a secluded and stable environment such as the deep sea.
- Published
- 2020
- Full Text
- View/download PDF
50. Metastatic Small-Cell Lung Cancer Presenting as Primary Adrenal Insufficiency.
- Author
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Esperti S, Stoelting A, Scibelli N, Moccia D, Patel D, Haughton M, and Mangano A
- Abstract
A 40-year-old male smoker with HIV was admitted for cough, hypotension, and abdominal pain for 5 days. Chest radiography showed a right lower lobe consolidation. CT of the chest, abdomen, and pelvis revealed paratracheal adenopathy, a 5.8 × 4.5 cm mass invading the right bronchus intermedius, and dense bilateral adrenal masses, measuring 5.4 × 4.0 cm on the right and 4.8 × 2.0 cm on the left. Laboratory studies showed white blood cell count of 18.5 K/mm
3 , sodium of 131 mmol/L, creatinine of 1.6 mg/dL, and CD4 count of 567 cells/mm3 . The random morning cortisol level was 7.0 μ g/dL, the ACTH stimulation test yielded inappropriate response, and a random serum ACTH was elevated at 83.4 pg/mL. MRI brain revealed no pituitary adenoma confirming primary adrenal insufficiency. The adrenal CT washout study was consistent with solid mass content, concerning for metastasis. Bronchoscopy with endobronchial mass and paratracheal lymph node biopsy confirmed small-cell lung cancer (SCLC). Intravenous steroids, 100 mg hydrocortisone every 8 hours, improved his hypotension and abdominal pain. PET scan revealed metabolically active right paratracheal mass, right hilar mass, and bilateral adrenal masses. Treatment included palliative chemotherapy consisting of carboplatin/etoposide/atezolizumab and chest radiation. We present this novel case to demonstrate SCLC's ability to cause primary adrenal insufficiency, as well as evaluate clinical response to chemotherapeutics., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2020 Shawn Esperti et al.)- Published
- 2020
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