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273 results on '"McNamara, Maria"'

14. The critical need to accelerate cerebral palsy research with consumer engagement, global networks, and adaptive designs.

Author

Thomas, Sruthi P., Novak, Iona, Ritterband-Rosenbaum, Anina, Lind, Karin, Webb, Annabel, Gross, Paul, and McNamara, Maria

Subjects
CEREBRAL palsy prevention, MIDDLE-income countries, PATIENTS, RESEARCH evaluation, MENTAL illness, CLINICAL medicine research, HOSPITAL emergency services, EMERGENCY medical services, GLOBAL burden of disease, NEUROLOGICAL disorders, EXPERIMENTAL design, MEDICAL research, PRIORITY (Philosophy), QUALITY of life, HEALTH information systems, MEDICAL needs assessment, PATIENT participation, LOW-income countries
Abstract

The prevalence of cerebral palsy (CP) varies globally, with higher rates and burden of disease in low- and middle-income countries. CP is a lifelong condition with no cure, presenting diverse challenges such as motor impairment, epilepsy, and mental health disorders. Research progress has been made but more is needed, especially given consumer demands for faster advancements and improvements in the scientific evidence base for interventions. This paper explores three strategies to accelerate CP research: consumer engagement, global clinical trial networks, and adaptive designs. Consumer engagement involving individuals with lived experience enhances research outcomes. Global clinical trial networks provide efficiency through larger and more diverse participant pools. Adaptive designs, unlike traditional randomized controlled trials, allow real-time modifications based on interim analyses, potentially answering complex questions more efficiently. The establishment of a CP Global Clinical Trials Network, integrating consumer engagement, global collaboration, and adaptive designs, marks a paradigm shift. The Network aims to address consumer-set research priorities. While challenges like ethical considerations and capacity building exist, the potential benefits for consumers, clinicians, researchers, and funding bodies are substantial. This paper underscores the urgency of transforming CP research methodologies for quicker translation of novel treatments into clinical practice to improve quality of life for those with CP. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Neurodevelopmental Therapy for Cerebral Palsy: A Meta-analysis

Author

te Velde, Anna, primary, Morgan, Catherine, additional, Finch-Edmondson, Megan, additional, McNamara, Lynda, additional, McNamara, Maria, additional, Paton, Madison Claire Badawy, additional, Stanton, Emma, additional, Webb, Annabel, additional, Badawi, Nadia, additional, and Novak, Iona, additional

Published
2022
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47. High-fidelity organic preservation of bone marrow in ca. 10 Ma amphibians

Author

McNamara, Maria E., Orr, Patrick J., Kearns, Stuart L., Alcala, Luis, Anadon, Pere, and Penalver-Molla, Enrique

Subjects
Fossils -- Research, Earth sciences
Abstract

Bone marrow in ca. 10 Ma frogs and salamanders from the Miocene of Libros, Spain, represents the first fossilized example of this extremely decay-prone tissue. The bone marrow, preserved in three dimensions as an organic residue, retains the original texture and red and yellow color of hematopoietic and fatty marrow, respectively; moldic osteoclasts and vascular structures are also present. We attribute exceptional preservation of the fossilized bone marrow to cryptic preservation: the bones of the amphibians formed protective microenvironments, and inhibited microbial infiltration. Specimens in which bone marrow is preserved vary in their completeness and articulation and in the extent to which the body outline is preserved as a thin film of organically preserved bacteria. Cryptic preservation of these labile tissues is thus to a large extent independent of, and cannot be predicted by, the taphonomic history of the remainder of the specimen. Keywords: taphonomy, organic preservation, bone marrow, Miocene, frogs, Spain.

Published
2006

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