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1. Superconductivity Discovered in Niobium Polyhydride at High Pressures

Author

He, X., Zhang, C. L., Li, Z. W., Lu, K., Zhang, S. J., Min, B. S., Zhang, J., Shi, L. C., Feng, S. M., Liu, Q. Q., Song, J., Wang, X. C., Peng, Y., Wang, L. H., Prakapenka, V. B., Chariton, S., Liu, H. Z., and Jin, C. Q.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Materials Science, Condensed Matter - Strongly Correlated Electrons
Abstract

Niobium polyhydride was synthesized at high pressure and high temperature conditions by using diamond anvil cell combined with in situ high pressure laser heating techniques. High pressure electric transport experiments demonstrate that superconducting transition occurs with critical temperature(Tc) 42 K at 187 GPa. The shift of Tc as function of external applied magnetic field is in consistent to the nature of superconductivity while the upper critical field at zero temperature Hc2(0) is estimated to~16.8 Tesla while the GL coherent length ~57 angstrom is estimated. The structure investigation using synchrotron radiation implies that the observed superconductivity may come from Fm-3m phase of NbH3.

Published
2024
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2. Multi-band analyses of the bright GRB 230812B and the associated SN2023pel

Author

Hussenot-Desenonges, T., Wouters, T., Guessoum, N., Abdi, I., Abulwfa, A., Adami, C., Fernández, J. F. Agüí, Ahumada, T., Aivazyan, V., Akl, D., Anand, S., Andrade, C. M., Antier, S., Ata, S. A., D'Avanzo, P., Azzam, Y. A., Baransky, A., Basa, S., Blazek, M., Bendjoya, P., Beradze, S., Boumis, P., Bremer, M., Brivio, R., Buat, V., Bulla, M., Burkhonov, O., Burns, E., Cenko, S. B., Corradi, W., Coughlin, M. W., Daigne, F., Dietrich, T., Dornic, D., Ducoin, J. -G., Duverne, P. -A., Elhosseiny, E. G., Elnagahy, F. I., El-Sadek, M. A., Ferro, M., Floc'h, E. Le, Freeberg, M., Fynbo, J. P. U., Götz, D., Gurbanov, E., Hamed, G. M., Hasanov, E., Healy, B. F., Heintz, K. E., Hello, P., Inasaridze, R., Iskandar, A., Ismailov, N., Izzo, L., Jhawar, S., Laz, T. Jegou du, Kamel, T. M., Karpov, S., Klotz, A., Koulouridis, E., Kuin, N. P., Kochiashvili, N., Leonini, S., Lu, K. -X., Malesani, D. B., Masek, M., Mao, J., Melandri, A., Mihov, B. M., Natsvlishvili, R., Navarete, F., Nedora, V., Nicolas, J., Odeh, M., Palmerio, J., Pang, P. T. H., De Pasquale, M., Peng, H. W., Pormente, S., Peloton, J., Pradier, T., Pyshna, O., Rajabov, Y., Rakotondrainibe, N. A., Rivet, J. -P., Rousselot, L., Saccardi, A., Sasaki, N., Schneider, B., Serrau, M., Shokry, A., Slavcheva-Mihova, L., Simon, A., Sokoliuk, O., Srinivasaragavan, G., Strausbaugh, R., Tanvir, N. R., Takey, A., Thöne, C. C., Tillayev, Y., Melo, I. Tosta e, Turpin, D., Postigo, A. de Ugarte, Vasylenko, V., Vergani, S. D., Vidadi, Z., Xu, D., Wang, L. T., Wang, X. F., Winters, J. M., Zhang, X -L., and Zhu, Z.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

GRB~230812B is a bright and relatively nearby ($z =0.36$) long gamma-ray burst (GRB) that has generated significant interest in the community and has thus been observed over the entire electromagnetic spectrum. We report over 80 observations in X-ray, ultraviolet, optical, infrared, and sub-millimeter bands from the GRANDMA (Global Rapid Advanced Network for Multi-messenger Addicts) network of observatories and from observational partners. Adding complementary data from the literature, we then derive essential physical parameters associated with the ejecta and external properties (i.e. the geometry and environment) of the GRB and compare with other analyses of this event. We spectroscopically confirm the presence of an associated supernova, SN2023pel, and we derive a photospheric expansion velocity of v $\sim$ 17$\times10^3$ km s$^{-1}$. We analyze the photometric data first using empirical fits of the flux and then with full Bayesian Inference. We again strongly establish the presence of a supernova in the data, with a maximum (pseudo-)bolometric luminosity of $5.75 \times 10^{42}$ erg/s, at $15.76^{+0.81}_{-1.21}$ days (in the observer frame) after the trigger, with a half-max time width of 22.0 days. We compare these values with those of SN1998bw, SN2006aj, and SN2013dx. Our best-fit model favours a very low density environment ($\log_{10}({n_{\rm ISM}/{\rm cm}^{-3}}) = -2.38^{+1.45}_{-1.60}$) and small values for the jet's core angle $\theta_{\rm core} = 1.54^{+1.02}_{-0.81} \ \rm{deg}$ and viewing angle $\theta_{\rm obs} = 0.76^{+1.29}_{-0.76} \ \rm{deg}$. GRB 230812B is thus one of the best observed afterglows with a distinctive supernova bump.

Published
2023

3. Superconductivity with Tc 116K discovered in antimony polyhydrides

Author

Lu, K., He, X., Zhang, C. L., Li, Z. W., Zhang, S. J., Min, B. S., Zhang, J., Zhao, J. F., Shi, L. C., Peng, Y., Feng, S. M., Liu, Q. Q., Song, J., Yu, R. C., Wang, X. C., Wang, Y., Bykov, M., and Jin, C. Q.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Materials Science, Condensed Matter - Strongly Correlated Electrons
Abstract

Superconductivity (SC) was experimentally observed for the first time in antimony polyhydride. The diamond anvil cell combined with laser heating system was used to synthesize the antimony polyhydride sample at high pressure and high temperature conditions. In-situ high pressure transport measurements as function of temperature with applied magnet are performed to study the SC properties. It was found that the antimony polyhydride samples show superconducting transition with critical temperature Tc 116 K at 184 GPa. The investigation of SC at magnetic field revealed that the superconducting coherent length ~40 angstroms based on Ginzburg Landau (GL) equation. Antimony polyhydride superconductor has the second highest Tc in addition to sulfur hydride among the polyhydrides of elements from main group IIIA to VIIA in periodic table.

Published
2023
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4. Polydopamine-Based Targeted Nanosystem for Chemo/Photothermal Therapy of Retinoblastoma in a Mouse Orthotopic Model

Author

Jin B, Lu K, Gao W, Liu Y, Wang M, Zhang X, Chen H, Zheng L, and Zou M

Subjects
retinoblastoma, orthotopic model, nanoparticle, synergistic therapy, Medicine (General), R5-920
Abstract

Bo Jin,1 Kexin Lu,2 Wenna Gao,1 Yixian Liu,3 Mengfei Wang,2 Xiaojun Zhang,3 Huiping Chen,3 Liyun Zheng,3 Min Zou3 1Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Hennan, 450052, People’s Republic of China; 2BGI College, Zhengzhou University, Zhengzhou, 450052, People’s Republic of China; 3Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450052, People’s Republic of ChinaCorrespondence: Min Zou; Liyun Zheng, Email Minzou1980@126.com; zhengliyun@zzu.edu.cnBackground: At present, the few photothermal/chemotherapy studies about retinoblastoma that have been reported are mainly restricted to ectopic models involving subcutaneous implantation. However, eyeball is unique physiological structure, the blood-retina barrier (BRB) hinders the absorption of drug molecules through the systemic route. Moreover, the abundant blood circulation in the fundus accelerates drug metabolism. To uphold the required drug concentration, patients must undergo frequent chemotherapy sessions.Purpose: To address these challenges above, we need to develop a secure and effective drug delivery system (FA-PEG-PDA-DOX) for the fundus.Methods: We offered superior therapeutic efficacy with minimal or no side effects and successfully established orthotopic mouse models. We evaluated cellular uptake performance and targeting efficiency of FA-PEG-PDA-DOX nanosystem and assessed its synergistic antitumor effects in vitro and vivo. Biodistribution assessments were performed to determine the retention time and targeting efficiency of the NPs in vivo. Additionally, safety assessments were conducted.Results: Cell endocytosis rates of the FA-PEG-PDA-DOX+Laser group became 5.23 times that of the DOX group and 2.28 times that of FA-PEG-PDA-DOX group without irradiation. The fluorescence signal of FA-PEG-PDA-DOX persisted for more than 120 hours at the tumor site. The number of tumor cells (17.2%) in the proliferative cycle decreased by 61.6% in the photothermal-chemotherapy group, in contrast to that of the saline control group (78.8%). FA-PEG-PDA-DOX nanoparticles(NPs) exhibited favorable biosafety and high biocompatibility.Conclusion: The dual functional targeted nanosystem, with the effects of DOX and mild-temperature elevation by irradiation, resulted in precise chemo/photothermal therapy in nude mice model.Keywords: retinoblastoma, orthotopic model, nanoparticle, synergistic therapy

Published
2024

5. Understanding the Anomalous Hall effect in Co$_{1/3}$NbS$_{2}$ from crystal and magnetic structures

Author

Lu, K., Murzabekova, A., Shim, S., Park, J., Kim, S., Kish, L., Wu, Y., DeBeer-Schmitt, L., Aczel, A. A., Schleife, A., Mason, N., Mahmood, F., and MacDougall, G. J.

Subjects
Condensed Matter - Materials Science
Abstract

A large anomalous Hall effect (AHE) has recently been observed in the intercalated transition metal dichalcogenide (TMDC) Co$_{1/3}$NbS$_{2}$ below a known magnetic phase transition at $T_N$ = 29 K. The spins in this material are widely believed to order in a highly symmetric collinear antiferromagnetic configuration, causing extensive debate about how reports of an AHE can be reconciled with such a state. In this article, we address this controversy by presenting new neutron diffraction data on single crystals of Co$_{1/3}$NbS$_{2}$ and an analysis that implies that moments in this material order into a non-collinear configuration, but one that maintains the same refelction symmetries as the collinear phase. We present new transport and magneto-optic Kerr measurements which show that AHE signatures persist below $T_N$ to temperatures as low as $T$ = 5 K and firmly associate them with the long-range antiferromagnetic order. Finally, we show that these AHE signatures can be quantitatively reproduced by density functional theory (DFT) calculations based on the lattice and spin state determined with neutron diffraction. These combined findings establishes the veracity of the 'crystal Hall effect' picture, which shows how such effects can emerge from the shape of magnetic orbitals in compounds containing chiral lattice symmetry regardless of the symmetry of the ordered spin configuration. These results illuminate a new path for the discovery of anomalous Hall materials and motivate a targeted study of the transport properties of intercalated TMDCs and other compounds containing antiferromagnetic order and chiral lattice symmetry., Comment: 13 pages, 7 figures

Published
2022

6. Superconductivity Observed in Tantalum Polyhydride at High Pressure

Author

He, X., Zhang, C. L., Li, Z. W., Zhang, S. J., Min, B. S., Zhang, J., Lu, K., Zhao, J. F., Shi, L. C., Peng, Y., Wang, X. C., Feng, S. M., Song, J., Wang, L. H., Prakapenka, V. B., Chariton, S., Liu, H. Z., and Jin, C. Q.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Materials Science
Abstract

We report experimental discovery of tantalum polyhydride superconductor. It was synthesized at high pressure and high temperature conditions using diamond anvil cell combined with in-situ high pressure laser heating techniques. The superconductivity was investigated via resistance measurements at pressures. The highest superconducting transition temperature Tc was found to be ~30 K at 197 GPa in the sample that was synthesized at the same pressure with ~2000 K heating. The transitions are shifted to low temperature upon applying magnetic fields that supports the superconductivity nature. The upper critical field at zero temperature {\mu}0Hc2(0) of the superconducting phase is estimated to be ~20 T that corresponds to GL coherent length ~40 angstroms. Our results suggest that the superconductivity may arise from I-43d phase of TaH3. It is, for the first time to our best knowledge, experimental realization of superconducting hydrides for the VB group of transitional metals., Comment: Published by CPL

Published
2022
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8. A Report of Two Cases of Meningoencephalitis Caused by Streptococcus intermedius

Author

Pan JL, Wu WJ, Zeng SY, Xu JH, and Lu K

Subjects
genome sequencing, meningoencephalitis, multiple cerebral abscesses streptococcus intermedius, Infectious and parasitic diseases, RC109-216
Abstract

Jun-Li Pan,1 Wen-Jun Wu,1 Shu-Yan Zeng,2 Jia-He Xu,1 Kui Lu1 1Department of Neurology, Zhongshan City People’s Hospital, Zhongshan, Guangdong province, 528403, People’s Republic of China; 2Department of MRI Room, Zhongshan City People’s Hospital, Zhongshan, Guangdong province, 528403, People’s Republic of ChinaCorrespondence: Kui Lu, Department of Neurology, Zhongshan City People’s Hospital, No. 2 of Sunwen East Road, Zhongshan City, Guangdong Province, 528403, People’s Republic of China, Tel +86 0760-89880211, Fax +86 0760-88841707, Email lukui_zs@163.comObjective: In this paper, we analyzed the clinical data of patients with meningoencephalitis caused by Streptococcus intermedius to understand better the clinical characteristics of the disease and recommend auxiliary diagnostic mode as well as treatment experience.Methods: We reviewed the clinical data of two patients admitted to our department in 2019 with meningoencephalitis caused by S. intermedius.Results: Two female patients were examined, one of whom had a history of radiotherapy for nasopharyngeal carcinoma while the other had no underlying disease. These two patients were admitted with symptoms of meningoencephalitis. Cerebrospinal fluid examinations revealed elevated levels of leukocytes and protein. After treatment with meropenem, the condition improved for a brief time, but then worsened with a decline in mental status and limb movement. Blood and cerebrospinal fluid cultures demonstrated the absence of pathogenic bacteria, while genome sequencing of cerebrospinal fluids revealed the presence of S. intermedius. Cranial magnetic resonance imaging revealed multiple cerebral abscesses (CAs). After coadministration of linezolid as an anti-infective, clinical symptoms gradually improved, and the CAs shrank on follow-up imaging. The condition exhibited a pattern of improvement-deterioration-improvement.Conclusion: Meningoencephalitis caused by S. intermedius is complex and prone to fluctuation and formation of multiple CAs. The definitive clinical diagnosis of this disease can be aided by genome sequencing technology, and early clarification of the etiology combined with the use of potent antibiotics is effective.Keywords: Genome sequencing, meningoencephalitis, multiple cerebral abscesses Streptococcus intermedius

Published
2024

9. Traditional and Non-Traditional Lipid Parameters in Relation to Parenchymal Hemorrhage Following Endovascular Treatment for Acute Ischemic Stroke in Anterior Circulation

Author

Sun J, Zhang J, Xin B, Ye Z, Cai Y, Lu K, Wang Y, Lei X, Zheng C, and Cai X

Subjects
endovascular treatment, hemorrhagic transformation, serum lipids, Geriatrics, RC952-954.6
Abstract

Jingping Sun,1,2,* Jun Zhang,3,* Bailong Xin,1 Zekang Ye,1,2 Yaozhuo Cai,2 Ke Lu,2 Yuzhen Wang,2 Xueyao Lei,2 Chanjuan Zheng,2 Xueli Cai3 1Department of Neurology, the Municipal Central Hospital of Lishui, Fifth Affiliated Hospital of Wenzhou Medical College, Lishui, Zhejiang, People’s Republic of China; 2Lishui Clinical Research Center for Neurological Diseases, Lishui, Zhejiang, People’s Republic of China; 3Zhejiang University, School of Medicine, Hangzhou, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xueli Cai, Department of Neurology, the Municipal Central Hospital of Lishui, Fifth Affiliated Hospital of Wenzhou Medical College, Lishui, Zhejiang, People’s Republic of China, Email xueli_cai_official@126.comPurpose: Lipid-lowering therapy is integral in acute ischemic stroke (AIS), yet the connection between lipid parameters and parenchymal hemorrhage (PH) after endovascular treatment (EVT) for AIS is not well-defined. This research aims to assess the association between various lipid parameters and the PH risk following EVT.Patients and Methods: We examined a database of patients who underwent EVT for AIS between September 2021 and May 2023 retrospectively. Traditional and non-traditional lipid parameters were documented. PH was identified on dual energy computed tomography images within 48 h. We employed logistic regression analysis and restricted cubic splines to examine the association between various lipid parameters and the risk of PH. The predictive capacity of the lipid parameters for PH was evaluated by comparing the area under the curve.Results: The study included 384 patients, 65 of whom (17.7%) developed PH. After adjusting for potential confounders, only triglyceride was associated with PH among the traditional lipid parameters, while all non-traditional lipid parameters were related to PH. Based on ROC curve, the ratio of remnant cholesterol to high-density lipoprotein cholesterol (RC/HDL-C) exhibited the highest predictive capability for PH. Furthermore, our analysis revealed a significant nonlinear correlation between triglyceride, non-high-density lipoprotein cholesterol, RC, RC/HDL-C and PH risk.Conclusion: In assessing the risk of PH after EVT, non-traditional lipid parameters are often superior to traditional lipid parameters. It is recommended that routine evaluation of non-traditional lipid parameters could also be conducted in clinical practice as well.Keywords: endovascular treatment, hemorrhagic transformation, serum lipids

Published
2024

10. Superconductivity above 80 K in polyhydrides of hafnium

Author

Zhang, C. L., He, X., Li, Z. W., Zhang, S. J., Min, B. S., Zhang, J., Lu, K., Zhao, J. F., Shi, L. C., Peng, Y., Wang, X. C., Feng, S. M., Yu, R. C., Wang, L. H., Prakapenka, V. B., Chariton, S., Liu, H. Z., and Jin, C. Q.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Materials Science
Abstract

Studies on polyhydrides are attracting growing attentions recently due to their potential high temperature superconductivity (SC). We here report the discovery of SC in hafnium polyhydrides at high pressures. The hafnium superhydrides are synthesized at high pressure and high temperature conditions using diamond anvil cell in combination with in-situ high pressure laser heating technique. The SC was investigated by in-situ high pressure resistance measurements in applied magnetic fields. A superconducting transition with onset Tc ~83 K was observed at 243 GPa. The upper critical field Hc2(0) was estimated to be 24 Tesla by GL theory and the consequent superconducting coherent length to be ~37 angstrom. Our results suggest that the superconducting phase is from C2/m-HfH14. This is the first 5d transition metal polyhydride superconductor with Tc above the liquid nitrogen temperature., Comment: Accepted by the journal of Material Today Physics (2022)

Published
2022

12. Sleep Duration and Kidney Function – Does Weekend Sleep Matter?

Author

Wu CC, Yang PL, Kao LT, Liu YC, Zheng CM, Chu P, Lu K, Chu CM, and Chang YT

Subjects
weekend sleep duration, kidney function, national health and nutrition examination survey, estimated glomerular filtration rate, egfr, chronic kidney disease, ckd, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Chia-Chao Wu,1,2 Pei-Lin Yang,3 Li-Ting Kao,4– 6 Yi-Chun Liu,7,8 Cai-Mei Zheng,9 Pauling Chu,1 Kuo‐Cheng Lu,10 Chi-Ming Chu,7,11– 13 Yu-Tien Chang7 1Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; 2Department and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan; 3School of Nursing, National Defense Medical Center, Taipei City, Taiwan; 4School of Pharmacy, National Defense Medical Center, Taipei, Taiwan; 5Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan; 6Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan; 7School of Public Health, National Defense Medical Center, Taipei City, Taiwan; 8Institute of Medical Sciences, National Defense Medical Center, Taipei City, Taiwan; 9Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan; 10Division of Nephrology, Fu-Jen Catholic Hospital, Fu-Jen Catholic University, Taipei, Taiwan; 11Department of Surgery, Songshan Branch of Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taiwan; 12Division of Biostatistics and Informatics, Department of Epidemiology, School of Public Health, National Defense Medical Center, Taipei, Taiwan; 13Department of Public Health, China Medical University, Taichung City, TaiwanCorrespondence: Yu-Tien Chang, School of Public Health, National Defense Medical Center, No. 161, Sec. 6, Minquan E. Road, Neihu Dist, Taipei City, 11490, Taiwan, Tel +886-2-87923100#18454, Email greengarden720925@gmail.comObjective: Weekend sleep duration is linked to health issues, including mortality. However, how weekend sleep duration can impact chronic kidney disease (CKD) still needs to be understood. Therefore, we aimed to analyze how weekend sleep duration is associated with kidney function.Methods: This is a cross-sectional study. Data were obtained from the 2017– 2018 National Health and Nutrition Examination Survey. We included 5362 study participants and categorized them into nine subgroups by sleep duration (short: ≤ 6 hours, normal: 6– 9 hours, and long: ≥ 9 hours) on weekdays and weekends and analyzed for the respective association with renal function using stratified multivariable linear regression.Results: Weekend sleep duration for 9 hours or more was associated with decreasing estimated glomerular filtration rate (eGFR) levels by 2.8 to 6.4 mL/min/1.73 m2 among people with long to short weekday sleep duration compared with short weekday and weekend sleep durations (control group) after adjusting for demographic characteristics, body measurement, sleep quality, smoking, and comorbidities. The study population with short weekday sleep duration (sWK) and long weekend sleep duration (lWD) had the most significant decline in eGFR. For the study population with sWK, eGFR level significantly decreased by 1.1 mL/min/1.73 m2 as sleep duration on weekends increased by one hour.Conclusion: The underlying mediators of lWD and CKD could be the dysregulation of human behaviors, metabolism, or biological functions. Longer weekend sleep duration was linked to a decrease in eGFR levels. It warrants further study to clarify the mediators. Keywords: weekend sleep duration, kidney function, national health and nutrition examination survey, estimated glomerular filtration rate, eGFR, chronic kidney disease, CKD

Published
2024

15. Record High Tc Element Superconductivity Achieved In Titanium

Author

Zhang, C. L., He, X., Liu, C., Li, Z. W., Lu, K., Zhang, S. J., Feng, S. M., Wang, X. C., Peng, Y., Long, Y. W., Yu, R. C., Wang, L. H., Prakapenka, V. B., Chariton, S., Li, Q., Liu, H. Z., Chen, C. F., and Jin, C. Q.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Materials Science
Abstract

It is challenging to search for high Tc superconductivity (SC) in transition metal elements wherein d electrons are usually not favored by conventional BCS theory. Here we report discovery of surprising SC up to 310 GPa with Tc above 20 K in wide pressure range from 108 GPa to 240 GPa in titanium. The maximum Tc^onset above 26 K and zero resistance Tc^zero of 21 K are record high values hitherto achieved among element superconductors. The Hc2(0) is estimated to be about 32 Tesla with coherence length 32 angstrom. The results show strong s-d transfer and d-band dominance, indicating correlation driven contributions to high Tc SC in dense titanium. This finding is in sharp contrast to the theoretical predications based on pristine electron-phonon coupling scenario. The study opens a fresh promising avenue for rational design and discovery of high Tc superconductors among simple materials via pressure tuned unconventional mechanism.

Published
2021
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16. Triaxially strained suspended graphene for large-area pseudo-magnetic fields

Author

Luo, M., Sun, H., Qi, Z., Lu, K., Chen, M., Kang, D., Kim, Y., Burt, D., Yu, X., Wang, C., Kim, Y. D., Wang, H., Wang, Q. -J., and Nam, D.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Strain-engineered graphene has garnered much attention recently owing to the possibilities of creating substantial energy gaps enabled by pseudo-magnetic fields. While theoretical works proposed the possibility of creating large-area pseudo-magnetic fields by straining monolayer graphene along three crystallographic directions, clear experimental demonstration of such promising devices remains elusive. Herein, we experimentally demonstrate a triaxially strained suspended graphene structure that has the potential to possess large-scale and quasi-uniform pseudo-magnetic fields. Our structure employs uniquely designed metal electrodes that function both as stressors and metal contacts for current injection. Raman characterization and tight-binding simulations suggest the possibility of achieving pseudo-magnetic fields over a micrometer-scale area. Current-voltage measurements confirm an efficient current injection into graphene, showing the potential of our devices for a new class of optoelectronic applications. We also theoretically propose a photonic crystal-based laser structure that obtains strongly localized optical fields overlapping with the spatial area under uniform pseudo-magnetic fields, thus presenting a practical route towards the realization of graphene lasers.

Published
2021
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18. Superconductivity above 200 K Observed in Superhydrides of Calcium

Author

Li, Z., He, X., Zhang, C. L., Wang, X. C., Zhang, S. J., Jia, Y. T., Feng, S. M., Lu, K., Zhao, J. F., Zhang, J., Min, B. S., Long, Y. W., Yu, R. C., Wang, L. H., Ye, M. Y., Zhang, Z. S., Prakapenka, V., Chariton, S., Ginsberg, P. A., Bass, J., Yuan, S. H., Liu, H. Z., and Jin, C. Q.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Materials Science, Condensed Matter - Strongly Correlated Electrons
Abstract

Searching for superconductivity with Tc near room temperature is of great interest both for fundamental science & many potential applications. Here we report the experimental discovery of superconductivity with maximum critical temperature (Tc) above 210 K in calcium superhydrides, the new alkali earth hydrides experimentally showing superconductivity above 200 K in addition to sulfur hydride & rare-earth hydride system. The materials are synthesized at the synergetic conditions of 160~190 GPa and ~2000 K using diamond anvil cell combined with in-situ laser heating technique. The superconductivity was studied through in-situ high pressure electric conductance measurements in an applied magnetic field for the sample quenched from high temperature while maintained at high pressures. The upper critical field Hc(0) was estimated to be ~268 T while the GL coherent length is ~11 angstrom. The in-situ synchrotron X-ray diffraction measurements suggest that the synthesized calcium hydrides are primarily composed of CaH6 while there may also exist other calcium hydrides with different hydrogen contents.

Published
2021
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20. Development of a Clinical-Radiomics Nomogram That Used Contrast-Enhanced Ultrasound Images to Anticipate the Occurrence of Preoperative Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma Patients

Author

Wei T, Wei W, Ma Q, Shen Z, Lu K, and Zhu X

Subjects
lymph node metastasis, radiomics, papillary thyroid carcinoma, contrast-enhanced ultrasound, b-mode ultrasound., Medicine (General), R5-920
Abstract

Tianjun Wei,1,2 Wei Wei,2 Qiang Ma,2 Zhongbing Shen,2 Kebing Lu,2 Xiangming Zhu1,2 1School of Continuing Education, Anhui Medical University, Hefei, 230032, People’s Republic of China; 2Department of Ultrasound, The First Affiliated Hospital of Wannan Medical College, Wuhu, 241001, People’s Republic of ChinaCorrespondence: Xiangming Zhu, School of Continuing Education, Anhui Medical University, NO. 81 Meishan Road, Shushan District, Hefei City, Anhui Province, 230032, People’s Republic of China, Tel +86 553-5739808, Email xiangmingzhudr@yeah.netBackground and Objectives: Papillary thyroid carcinoma (PTC) is a prevalent histological type of thyroid cancer; however, noninvasive assessment of cervical lymph node metastasis (LNM) poses a challenge. This study aims to develop a novel clinical-radiomics nomogram that utilizes ultrasound (US) images to predict the presence of cervical LNM metastasis in patients with PTC.Methods: A total of 423 patients with PTC were recruited to participate in this study between January 2020 and December 2022, of which 282 were classified into the training group and 141 patients were classified into the validation set. Contrast-enhanced ultrasound (CEUS) and B-mode ultrasound (BMUS) images were subjected to radiomic analysis, leading to the extraction of 912 radiomic features. Thereafter, a radiomics score (Radscore) was developed to effectively integrate the information derived from BMUS and CEUS modalities. Univariate and multivariate backward stepwise logistic regression analysis techniques were used to construct the clinical and clinical-radiomics models, respectively.Results: The findings revealed that the clinical-radiomics nomogram incorporated age, sex, CEUS Radscore, and US-reported LNM as risk factors. The nomogram demonstrated good performance using data from the training (AUC = 0.891) and validation (AUC = 0.870) sets. The decision curve analysis implied that this nomogram exhibited good clinical utility, which was further supported by the results of the calibration curves and Hosmer-Lemeshow test.Conclusion: The CEUS Radscore-based clinical radiomics nomogram could serve as a valuable tool for predicting cervical LNM metastasis in patients with PTC, thereby tailoring individualized treatment strategies for them.Keywords: lymph node metastasis, radiomics, papillary thyroid carcinoma, contrast-enhanced ultrasound, B-mode ultrasound

Published
2023

21. Structural, electronic, and magnetic properties of nearly-ideal $J_{\rm eff}$ $=$ 1/2 iridium halides

Author

Reig-i-Plessis, D., Johnson, T. A., Lu, K., Chen, Q., Ruff, J. P. C., Upton, M. H., Williams, T. J., Calder, S., Zhou, H. D., Clancy, J. P., Aczel, A. A., and MacDougall, G. J.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

Heavy transition metal magnets with $J_{\rm eff}$ $=$ 1/2 electronic ground states have attracted recent interest due to their penchant for hosting new classes of quantum spin liquids and superconductors. Unfortunately, model systems with ideal $J_{\rm eff}$ $=$ 1/2 states are scarce due to the importance of non-cubic local distortions in most candidate materials. In this work, we identify a family of iridium halide systems [i.e. K$_2$IrCl$_6$, K$_2$IrBr$_6$, (NH$_4$)$_2$IrCl$_6$, and Na$_2$IrCl$_6 \cdotp $ 6(H$_2$O)] with Ir$^{4+}$ electronic ground states in extremely close proximity to the ideal $J_{\rm eff}$ $=$ 1/2 limit, despite a variation in the low-temperature global crystal structures. We also find ordered magnetic ground states for the three anhydrous systems, with single crystal neutron diffraction on K$_2$IrBr$_6$ revealing Type-I antiferromagnetism. This spin configuration is consistent with expectations for significant Kitaev exchange in a face-centered-cubic magnet., Comment: 14 pages, 9 figures

Published
2020
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22. Spectroscopic Monitoring of Blazar S5 0716+714: Brightness-Dependent Spectral Behavior

Author

Feng, Hai-Cheng, Yang, Sen., Yang, Zi-Xu., Liu, H. T., Bai, J. M., Li, Sha-Sha., Zhao, X. H., Zhang, Jin., Li, Y. B., Xiao, M., Xin, Y. X., Xing, L. F., Lu, K. X., Xu, L., Wang, J. G., Wang, C. J., Zhang, X. L., Zhang, J. J., Lun, B. L., and He, S. S.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies
Abstract

In this paper, we report the new results of spectroscopic observations of $\gamma$-ray blazar S5 0716+714 from 2019 September to 2020 March with the 2.4 m optical telescope at Lijiang Observatory of Yunnan Observatories. The median cadence of observations is $\sim$ 1 day. During the second observation period (Epoch2), the observational data reveal an extremely bright state and a bluer-when-brighter (BWB) chromatism. The BWB trend of Epoch2 differs significantly from that of the first observation period (Epoch1). A significantly brightness-dependent BWB chromatism emerges in the total data of Epoch1 and Epoch2. The BWB trend becomes weaker towards the brighter states, and likely becomes saturated at the highest state. Based on a log-parabolic function, a power-law of synchrotron peak flux and frequency $\nu_{\rm{p}}$, and a power-law of the curvature of synchrotron spectrum and its $\nu_{\rm{p}}$, simulation well reproduces the brightness-dependent BWB trend of S5 0716+714. The BWB trend is seemingly controlled by the shift of $\nu_{\rm{p}}$ with respect to the observational window, and effectively may be dominated by the variations of electron average energy and magnetic field in emitting region., Comment: 16 pages, 5 figures, Accepted for publication in ApJ

Published
2020
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25. Diagnosis and management of isolated serous tubal intraepithelial carcinoma: A qualitative focus group study

Author

Negri, S, Fisch, C, de Hullu, J, van Bommel, M, Simons, M, Bogaerts, J, Apperloo, M, Baiocchi, G, Bakker, J, Bart, J, van Beekhuizen, H, Bernardini, M, Boere, I, Bulten, J, Chen, L, Chrzan, A, Dorum, A, Ewing-Graham, P, Ferrero, A, Floter Radestad, A, Fruscio, R, Gaarenstroom, K, Garcia, C, Harter, P, Hoogstad-van Evert, J, de Iaco, P, Klooster, A, Kooreman, L, Jacobsen, M, Kruse, A, Kwon, J, Lawson, B, Lax, S, van Lonkhuijzen, L, Lu, K, Manchanda, R, Marchetti, C, Mccluggage, W, Mcnally, O, Mourits, M, Nicum, S, Norquist, B, Perrone, A, Piek, J, Polastro, L, Polee, M, Rabban, J, Reesink, N, de los Reyes Oliver Perez, M, Roes, E, Rychlik, A, Shih, I, Soong, T, Speiser, P, Stone, R, Tamussino, K, Tognon, G, Tuninetti, V, Valabrega, G, Vos, M, Welz, J, Zizioli, V, Hermens, R, Steenbeek, M, Negri S., Fisch C., de Hullu J. A., van Bommel M., Simons M., Bogaerts J., Apperloo M. J. A., Baiocchi G., Bakker J. L., Bart J., van Beekhuizen H. J., Bernardini M. Q., Boere I., Bulten J., Chen L. -M., Chrzan A., Dorum A., Ewing-Graham P. C., Ferrero A., Floter Radestad A., Fruscio R., Gaarenstroom K. N., Garcia C., Harter P., Hoogstad-van Evert J. S., de Iaco P., Klooster A., Kooreman L. F. S., Jacobsen M., Kruse A. -J., Kwon J. S., Lawson B. C., Lax S. F., van Lonkhuijzen L. R. C. W., Lu K. H., Manchanda R., Marchetti C., McCluggage W. G., McNally O. M., Mourits M. J. E., Nicum S., Norquist B. M., Perrone A. M., Piek J. M. J., Polastro L., Polee M. B., Rabban J. T., Reesink N., de los Reyes Oliver Perez M., Roes E. -M., Rychlik A., Shih I. -M., Soong T. R., Speiser P., Stone R. L., Tamussino K., Tognon G., Tuninetti V., Valabrega G., Vos M. C., Welz J., Zizioli V., Hermens R. P. M. G., Steenbeek M. P., Negri, S, Fisch, C, de Hullu, J, van Bommel, M, Simons, M, Bogaerts, J, Apperloo, M, Baiocchi, G, Bakker, J, Bart, J, van Beekhuizen, H, Bernardini, M, Boere, I, Bulten, J, Chen, L, Chrzan, A, Dorum, A, Ewing-Graham, P, Ferrero, A, Floter Radestad, A, Fruscio, R, Gaarenstroom, K, Garcia, C, Harter, P, Hoogstad-van Evert, J, de Iaco, P, Klooster, A, Kooreman, L, Jacobsen, M, Kruse, A, Kwon, J, Lawson, B, Lax, S, van Lonkhuijzen, L, Lu, K, Manchanda, R, Marchetti, C, Mccluggage, W, Mcnally, O, Mourits, M, Nicum, S, Norquist, B, Perrone, A, Piek, J, Polastro, L, Polee, M, Rabban, J, Reesink, N, de los Reyes Oliver Perez, M, Roes, E, Rychlik, A, Shih, I, Soong, T, Speiser, P, Stone, R, Tamussino, K, Tognon, G, Tuninetti, V, Valabrega, G, Vos, M, Welz, J, Zizioli, V, Hermens, R, Steenbeek, M, Negri S., Fisch C., de Hullu J. A., van Bommel M., Simons M., Bogaerts J., Apperloo M. J. A., Baiocchi G., Bakker J. L., Bart J., van Beekhuizen H. J., Bernardini M. Q., Boere I., Bulten J., Chen L. -M., Chrzan A., Dorum A., Ewing-Graham P. C., Ferrero A., Floter Radestad A., Fruscio R., Gaarenstroom K. N., Garcia C., Harter P., Hoogstad-van Evert J. S., de Iaco P., Klooster A., Kooreman L. F. S., Jacobsen M., Kruse A. -J., Kwon J. S., Lawson B. C., Lax S. F., van Lonkhuijzen L. R. C. W., Lu K. H., Manchanda R., Marchetti C., McCluggage W. G., McNally O. M., Mourits M. J. E., Nicum S., Norquist B. M., Perrone A. M., Piek J. M. J., Polastro L., Polee M. B., Rabban J. T., Reesink N., de los Reyes Oliver Perez M., Roes E. -M., Rychlik A., Shih I. -M., Soong T. R., Speiser P., Stone R. L., Tamussino K., Tognon G., Tuninetti V., Valabrega G., Vos M. C., Welz J., Zizioli V., Hermens R. P. M. G., and Steenbeek M. P.

Abstract

Objective: A Serous Tubal Intraepithelial Carcinoma (STIC) without concomitant invasive carcinoma is occasionally identified and associated with a high risk of subsequent peritoneal carcinomatosis. Management needs optimisation. This study explores professionals' opinions and clinical practices regarding the diagnosis, counselling, treatment and follow-up of isolated STIC to facilitate clinical decision making and optimise the direction of future research. A secondary aim is to assess international clinical guidelines. Design: Focus group study. Setting: Four online sessions. Population: International panel (n = 12 countries) of gynaecologists, gynaecologic oncologists, pathologists and medical oncologists (n = 49). Methods: A semi-structured interview guide was used. Two independent researchers analysed transcripts by open and axial coding. Results were organised in domains. Relevant (inter)national guidelines were screened for recommendations regarding isolated STIC. Main Outcome Measures: Professionals' opinions and clinical practices regarding isolated STIC management. Results: Regarding pathology, most professionals identified the SEE-FIM protocol as standard of care for high-risk patients, whereas variation exists in the histopathological examination of fallopian tubes in the general population. Confirmation of STIC diagnosis by a specialised pathologist was recommended. Regarding work-up and follow-up after STIC diagnosis, there was variety and discordance. Data on outcomes is limited. As for treatment, chemotherapy and PARP inhibitors were not recommended by most. Eleven guidelines provided limited recommendations. Conclusions: We identified recommendations and highlighted knowledge gaps in the diagnosis and management of isolated STIC. Moreover, recommendations in clinical guidelines are limited. There is an agreed need for international collaboration for the prospective registration of isolated STIC.

Published
2024

26. Effects of General Anesthesia on Changes of Serum Hepatitis B Virus-DNA Levels in Infected Patients Underwent Non-Hepatobiliary Minimally Invasive Surgery: A Pilot Observational Study

Author

Quan J, Chen X, Tang X, Liu X, Li J, Yi B, Li P, Lu K, and Gu J

Subjects
general anesthesia, hepatitis b virus deoxyribonucleic acid, lymphocyte subsets, immune function., Infectious and parasitic diseases, RC109-216
Abstract

Junxian Quan1 &ast;, Xingtong Chen1 &ast;, Xi Tang,1 Xianzhe Liu,1 Jieyu Li,1 Bin Yi,1 Peng Li,2 Kaizhi Lu,1 Jianteng Gu1 1Department of Anesthesiology, The First Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, People’s Republic of China; 2Department of Pharmacognosy and Traditional Chinese Medicine, Third Military Medical University (Army Medical University), Chongqing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jianteng Gu; Kaizhi Lu, Department of Anesthesiology, The First Affiliated Hospital, Third Military Medical University (Army Medical University), 30 Gao Tanyan Street, Chongqing, 400038, People’s Republic of China, Tel +86 23 68766122, Fax +86 23 65463270, Email jiantenggu@hotmail.com; Lukaizhi@163.netObjective: To investigate the effects of different general anesthesia methods on the changes of serum hepatitis B virus deoxyribonucleic acid (HBV-DNA) levels in the hepatitis B virus (HBV) infected patients.Methods: This pilot prospective observational study was carried out from March 2021 to January 2022. Forty patients infected by HBV, who underwent non-hepatobiliary minimally invasive surgery, were allocated into an intravenous anesthesia group maintained with propofol (Group P, n = 20) and an inhalation anesthesia group maintained with sevoflurane (Group S, n = 20) by a random envelope method. Patient’s blood was drawn before operation (Tbaseline), at 24 hours (Tpost 24hrs) and 48 hours (Tpost 48hrs) after operation to detect the serum HBV-DNA levels and analyze the subset levels of T, B lymphocytes and NK cells (TBNK) in two groups. The serum HBV-DNA level was used as the major outcome, and it was analyzed by repeated-measures analysis of variance after natural logarithm transformation.Results: In Group P and Group S, compared with the baseline, the serum HBV-DNA levels decreased significantly at Tpost 24hrs and Tpost 48hrs, P< 0.05. The total ratio of CD4+T cells and the ratio of CD4+T to CD8+T cells (CD4+/CD8+) were lower at Tpost 24hrs, P< 0.05, and the total ratio of B cells was significantly increased at Tpost 24hrs, P< 0.05. Compared with the values at Tpost 24hrs, the total ratio of CD4+ T cells, CD4+/CD8+ T cells, and the total ratio of B cells were significantly increased at Tpost 48hrs in both groups, P< 0.05. However, there were no statistical differences between Group P and Group S.Conclusion: The levels of serum HBV-DNA decreased within 48 hours after general anesthesia. There were no significant differences between the effects of intravenous and inhalation anesthesia on the serum HBV-DNA levels.Trial Registration: This study has been prospectively registered in the Clinical Trials Registry (NCT02038088, 1/28/2015).Keywords: general anesthesia, hepatitis B virus deoxyribonucleic acid, lymphocyte subsets, immune function

Published
2022

34. Evaluating Sarcopenia by Using the Bioelectrical Impedance Analysis in Patients with Acute Myeloid Leukemia After Chemotherapy

Author

Qin Z, Lu K, Jiang T, Wang M, Weng Y, Tang X, and Zhao Y

Subjects
acute myeloid leukemia, sarcopenia, bioelectrical impedance analysis, mid-arm muscle circumference., Medicine (General), R5-920
Abstract

Zheng Qin,1 Kai Lu,2 Tiantian Jiang,3 Mei Wang,3 Yue Weng,3 Xiaoqiong Tang,3 Yu Zhao1 1Department of Vascular Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 2Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 3Department of hematopathology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of ChinaCorrespondence: Xiaoqiong TangDepartment of Hematopathology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong, Chongqing, 400016, People’s Republic of China, Email tlscqmu@126.comYu ZhaoDepartment of Vascular Surgery, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong, Chongqing, 400016, People’s Republic of China, Email zhaoyucqmu@126.comBackground: We aimed to explore the potential association of body composition parameters measured by bioelectrical impedance analysis (BIA) with the incidence of sarcopenia in patients with acute myeloid leukemia (AML) (non-M3) after chemotherapy.Patients and Methods: This was a single-center observational study. Sixty-nine patients with newly diagnosed AML underwent BIA at the time of initial diagnosis and after completion of three chemotherapy sessions. Pre- and post-chemotherapy BIA parameters were compared. Sarcopenia was defined as low skeletal muscle mass plus low muscle strength according to the Asian Working Group for Sarcopenia (AWGS). Association of sarcopenia with mid-arm muscle circumference (MAMC) and intracellular water (ICW) was assessed by multivariate logistic regression.Results: There was a significant increase in the prevalence of sarcopenia after chemotherapy (39.1% vs 14.5%, P< 0.001). Skeletal muscle mass (SMM), fat-free mass (FFM), and soft lean mass (SLM) showed a significant decrease after chemotherapy (P< 0.05). MAMC, ICW, and total body water (TBW) significantly decreased after chemotherapy (P< 0.05). BIA indices including appendicular skeletal muscle mass (ASM) (r=0.889, P< 0.001), ICW (r=0.869, P< 0.001), MAMC (r=0.849, P< 0.001) showed a positive correlation with SMI. Moreover, ASM (r=− 0.453 P=0.001), ICW (r=− 0.322, P< 0.05), and MAMC (r=− 0.352, P< 0.05) showed a negative correlation with sarcopenia. On multivariate logistic regression analysis, increased ICW was associated with decreased risk of sarcopenia [odds ratio (OR): 0.50; 95% confidence interval (CI) 0.30– 0.82]. Each additional unit of MAMC after chemotherapy was associated with 71% lower risk of sarcopenia (OR: 0.29; 95% CI 0.13– 0.66).Conclusion: The incidence of sarcopenia was associated with chemotherapy of patients with AML (non-M3) as reflected by body composition changes.Keywords: acute myeloid leukemia, sarcopenia, bioelectrical impedance analysis, mid-arm muscle circumference

Published
2022

35. Male Breast Carcinoma Metastatic to the Choroid: A Case Report and Opinions of Management

Author

Fu W, Zheng S, Zhou J, Lu K, Lu Y, and Guo G

Subjects
choroidal metastasis, male breast cancer, systemic therapy, cdk4/6 inhibitor, case report, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Weida Fu,&ast; Shurong Zheng,&ast; Jieyu Zhou, Kangkang Lu, Yiqiao Lu, Guilong Guo Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Guilong Guo, Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China, Tel/Fax +86-13867709361, Email guoguilong@sina.comAbstract: Male breast carcinoma metastatic to the choroid is very rare and often related to poor prognosis. Herein, we report the findings in a Chinese male breast cancer patient who developed choroidal metastasis, and give opinions on systemic treatments. A 45-year-old Chinese male represented with difficulty breathing and visual impairment in the left eye 6 years after his breast cancer surgery and postoperative adjuvant treatment. PET/CT revealed multi-organs metastasis of the patient. The IHC indicated the lung lesion to be originated from the breast (ER+/PR+/HER2-). Eye examination provided evidence for breast cancer choroidal metastasis. Two cycles of TX (docetaxel + capecitabine) followed by two courses of GP (gemcitabine + cis-platinum) were applied as salvage chemotherapy. Metastases in his lung and bone remained stable. As for choroidal metastasis, a regimen of CDK4/6 inhibitor (Palbociclib) plus fulvestrant was recommended to the patient, which led to a good response. Notably, CDK4/6 inhibitor combined with endocrine therapy may be considered as an effective treatment for hormonal receptor-positive breast cancer patients with choroidal metastasis. We recommend that eye examination should not be neglected in breast cancer patients.Keywords: choroidal metastasis, male breast cancer, systemic therapy, CDK4/6 inhibitor, case report

Published
2022

38. Multi-band analyses of the bright GRB 230812B and the associated SN2023pel

Author

Hussenot-Desenonges, T, primary, Wouters, T, additional, Guessoum, N, additional, Abdi, I, additional, Abulwfa, A, additional, Adami, C, additional, Fernández, J F Agüí, additional, Ahumada, T, additional, Aivazyan, V, additional, Akl, D, additional, Anand, S, additional, Andrade, C M, additional, Antier, S, additional, Ata, S A, additional, D’Avanzo, P, additional, Azzam, Y A, additional, Baransky, A, additional, Basa, S, additional, Blazek, M, additional, Bendjoya, P, additional, Beradze, S, additional, Boumis, P, additional, Bremer, M, additional, Brivio, R, additional, Buat, V, additional, Bulla, M, additional, Burkhonov, O, additional, Burns, E, additional, Cenko, S B, additional, Coughlin, M W, additional, Corradi, W, additional, Daigne, F, additional, Dietrich, T, additional, Dornic, D, additional, Ducoin, J-G, additional, Duverne, P-A, additional, Elhosseiny, E G, additional, Elnagahy, F I, additional, El-Sadek, M A, additional, Ferro, M, additional, Le Floc’h, E, additional, Freeberg, M, additional, Fynbo, J P U, additional, Götz, D, additional, Gurbanov, E, additional, Hamed, G M, additional, Hasanov, E, additional, Healy, B F, additional, Heintz, K E, additional, Hello, P, additional, Inasaridze, R, additional, Iskandar, A, additional, Ismailov, N, additional, Izzo, L, additional, Jhawar, S, additional, du Laz, T Jegou, additional, Kamel, T M, additional, Karpov, S, additional, Klotz, A, additional, Koulouridis, E, additional, Kuin, N P, additional, Kochiashvili, N, additional, Leonini, S, additional, Lu, K-X, additional, Malesani, D B, additional, Mašek, M, additional, Mao, J, additional, Melandri, A, additional, Mihov, B M, additional, Natsvlishvili, R, additional, Navarete, F, additional, Nedora, V, additional, Nicolas, J, additional, Odeh, M, additional, Palmerio, J, additional, Pang, P T H, additional, De Pasquale, M, additional, Peng, H W, additional, Pormente, S, additional, Peloton, J, additional, Pradier, T, additional, Pyshna, O, additional, Rajabov, Y, additional, Rakotondrainibe, N A, additional, Rivet, J-P, additional, Rousselot, L, additional, Saccardi, A, additional, Sasaki, N, additional, Schneider, B, additional, Serrau, M, additional, Shokry, A, additional, Slavcheva-Mihova, L, additional, Simon, A, additional, Sokoliuk, O, additional, Srinivasaragavan, G, additional, Strausbaugh, R, additional, Takey, A, additional, Tanvir, N R, additional, Thöne, C C, additional, Tillayev, Y, additional, Melo, I Tosta e, additional, Turpin, D, additional, de Ugarte Postigo, A, additional, Vasylenko, V, additional, Vergani, S D, additional, Vidadi, Z, additional, Xu, D, additional, Wang, L T, additional, Wang, X F, additional, Winters, J M, additional, Zhang, X-L, additional, and Zhu, Z, additional

Published
2024
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40. Intraoperative Hypotension and Related Risk Factors for Postoperative Mortality After Noncardiac Surgery in Elderly Patients: A Retrospective Analysis Report

Author

Zhao B, Chen X, Chen Q, Li G, Chen Z, Yang Z, Gu L, Xiao X, Wang Z, Ning J, Yi B, Lu K, Zhang H, and Gu J

Subjects
intraoperative hypotension, geriatric patients, copd, postoperative mortality, non-cardiac surgery, Geriatrics, RC952-954.6
Abstract

Benhui Zhao,1,&ast; Xingtong Chen,1,&ast; Qian Chen,1,2 Gaoming Li,3 Zhe Chen,4 Ziheng Yang,1 Li Gu,1 Xudong Xiao,5 Zhen Wang,6 Jiaolin Ning,1 Bin Yi,1 Kaizhi Lu,1 Hongyan Zhang,7 Jianteng Gu1 1Department of Anesthesiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, People’s Republic of China; 2Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London, UK; 3Department of Health Statistics, Third Military Medical University (Army Medical University), Chongqing, People’s Republic of China; 4Quality Management and Control Department, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, People’s Republic of China; 5Department of Anesthesiology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, People’s Republic of China; 6Department of Anesthesiology; 7Hospital Office, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jianteng Gu; Hongyan Zhang Email jiantenggu@hotmail.com; etengyan@163.comBackground: Blood pressure fluctuation is very common during non-cardiac surgery in elderly. This retrospective study was to analyse whether intraoperative hypotension in elderly and other risk factors relate to the postoperative mortality.Methods: A total of 118 cases (Observational group), who underwent noncardiac surgery in three medical centers between September 2014 and March 2017, and died in the hospital after the noncardiac surgery. With 1:2 ratio of propensity matching, 236 survival cases (Control group) were selected for comparison analyses with the death cases. Intraoperative blood pressure and perioperative parameters from both groups were collected from electronic anaesthesia charts. Data were analysed with univariate logistic regression analysis where variables with p values less than 0.05 were analysed with multivariate logistic regression analysis. The receiver operating characteristic (ROC) curve was constructed.Results: There are five risk factors related to postoperative death in elderly patients: ASA grade, COPD, emergency surgery, general anesthesia, 60 < MAP ≤ 65mmHg (OR > 1), and one factor may reduce the risk of postoperative mortality, which is PACU therapy (OR < 1). Compared with the Control group, the Observational group had a higher proportion of cerebral hernia, kidney injury and trauma (p < 0.001). The intraoperative blood transfusion volume and intraoperative blood loss volume were higher in the Observational group than the Control group (p < 0.001). The proportion of using vasoactive drugs was higher in the Observational group (p < 0.001), and there was more urine output during the operation in the Observational group (p = 0.005).Conclusion: The intraoperative MAP of geriatric patients lower than 65mmHg is highly related to the postoperative mortality. Elderly patients with emergency surgery, high ASA grade and a history of COPD have an increased risk of postoperative mortality. General anesthesia is a risk factor for postoperative death in elderly patients, and the PACU therapy is a protective factor to avoid postoperative death.Trial Registration: This study has been retrospectively registered in the Chinese Clinical Trials Registry (ChiCTR2000038912, 10/10/2020).Keywords: intraoperative hypotension, geriatric patients, COPD, postoperative mortality, non-cardiac surgery

Published
2021

45. The role of ceramic and glass science research in meeting societal challenges: Report from an NSF-sponsored workshop

Author

Faber, KT, Asefa, T, Backhaus-Ricoult, M, Brow, R, Chan, JY, Dillon, S, Fahrenholtz, WG, Finnis, MW, Garay, JE, García, RE, Gogotsi, Y, Haile, SM, Halloran, J, Hu, J, Huang, L, Jacobsen, SD, Lara-Curzio, E, LeBeau, J, Lee, WE, Levi, CG, Levin, I, Lewis, JA, Lipkin, DM, Lu, K, Luo, J, Maria, JP, Martin, LW, Martin, S, Messing, G, Navrotsky, A, Padture, NP, Randall, C, Rohrer, GS, Rosenflanz, A, Schaedler, TA, Schlom, DG, Sehirlioglu, A, Stevenson, AJ, Tani, T, Tikare, V, Trolier-McKinstry, S, Wang, H, and Yildiz, B

Subjects
defects, glass, layered ceramics, processing, ultrahigh-temperature ceramics, Materials, Materials Engineering, Mechanical Engineering
Abstract

Under the sponsorship of the U.S. National Science Foundation, a workshop on emerging research opportunities in ceramic and glass science was held in September 2016. Reported here are proceedings of the workshop. The report details eight challenges identified through workshop discussions: Ceramic processing: Programmable design and assembly; The defect genome: Understanding, characterizing, and predicting defects across time and length scales; Functionalizing defects for unprecedented properties; Ceramic flatlands: Defining structure-property relations in free-standing, supported, and confined two-dimensional ceramics; Ceramics in the extreme: Discovery and design strategies; Ceramics in the extreme: Behavior of multimaterial systems; Understanding and exploiting glasses and melts under extreme conditions; and Rational design of functional glasses guided by predictive modeling. It is anticipated that these challenges, once met, will promote basic understanding and ultimately enable advancements within multiple sectors, including energy, environment, manufacturing, security, and health care.

Published
2017

49. INX-315, a Selective CDK2 Inhibitor, Induces Cell Cycle Arrest and Senescence in Solid Tumors

Author

Dietrich, C, Trub, A, Ahn, A, Taylor, M, Ambani, K, Chan, KT, Lu, K-H, Mahendra, CA, Blyth, C, Coulson, R, Ramm, S, Watt, AC, Matsa, SK, Bisi, J, Strum, J, Roberts, P, Goel, S, Dietrich, C, Trub, A, Ahn, A, Taylor, M, Ambani, K, Chan, KT, Lu, K-H, Mahendra, CA, Blyth, C, Coulson, R, Ramm, S, Watt, AC, Matsa, SK, Bisi, J, Strum, J, Roberts, P, and Goel, S

Abstract

Cyclin-dependent kinase 2 (CDK2) is thought to play an important role in driving proliferation of certain cancers, including those harboring CCNE1 amplification and breast cancers that have acquired resistance to CDK4/6 inhibitors (CDK4/6i). The precise impact of pharmacologic inhibition of CDK2 is not known due to the lack of selective CDK2 inhibitors. Here we describe INX-315, a novel and potent CDK2 inhibitor with high selectivity over other CDK family members. Using cell-based assays, patient-derived xenografts (PDX), and transgenic mouse models, we show that INX-315 (i) promotes retinoblastoma protein hypophosphorylation and therapy-induced senescence (TIS) in CCNE1-amplified tumors, leading to durable control of tumor growth; (ii) overcomes breast cancer resistance to CDK4/6i, restoring cell cycle control while reinstating the chromatin architecture of CDK4/6i-induced TIS; and (iii) delays the onset of CDK4/6i resistance in breast cancer by driving deeper suppression of E2F targets. Our results support the clinical development of selective CDK2 inhibitors.

Published
2024

50. Multiband analyses of the bright GRB 230812B and the associated SN2023pel

Author

Sub GRASP, Gravitational and Subatomic Physics (GRASP), Hussenot-Desenonges, T., Wouters, T., Guessoum, N., Abdi, I., Abulwfa, A., Adami, C., Agüí Fernández, J. F., Ahumada, T., Aivazyan, V., Akl, D., Anand, S., Andrade, C. M., Antier, S., Ata, S. A., D'Avanzo, P., Azzam, Y. A., Baransky, A., Basa, S., Blazek, M., Bendjoya, P., Beradze, S., Boumis, P., Bremer, M., Brivio, R., Buat, V., Bulla, M., Burkhonov, O., Burns, E., Cenko, S. B., Coughlin, M. W., Corradi, W., Daigne, F., Dietrich, T., Dornic, D., Ducoin, J. G., Duverne, P. A., Elhosseiny, E. G., Elnagahy, F. I., El-Sadek, M. A., Ferro, M., Le Floc'H, E., Freeberg, M., Fynbo, J. P.U., Götz, D., Gurbanov, E., Hamed, G. M., Hasanov, E., Healy, B. F., Heintz, K. E., Hello, P., Inasaridze, R., Iskandar, A., Ismailov, N., Izzo, L., Jhawar, S., Jegou du Laz, T., Kamel, T. M., Karpov, S., Klotz, A., Koulouridis, E., Kuin, N. P., Kochiashvili, N., Leonini, S., Lu, K. X., Malesani, D. B., Mašek, M., Mao, J., Melandri, A., Mihov, B. M., Natsvlishvili, R., Navarete, F., Nedora, V., Nicolas, J., Odeh, M., Palmerio, J., Pang, P. T.H., De Pasquale, M., Peng, H. W., Pormente, S., Peloton, J., Pradier, T., Pyshna, O., Rajabov, Y., Rakotondrainibe, N. A., Rivet, J. P., Rousselot, L., Saccardi, A., Sasaki, N., Schneider, B., Serrau, M., Shokry, A., Slavcheva-Mihova, L., Simon, A., Sokoliuk, O., Srinivasaragavan, G., Strausbaugh, R., Takey, A., Tanvir, N. R., Thöne, C. C., Tillayev, Y., Tosta e Melo, I., Turpin, D., de Ugarte Postigo, A., Vasylenko, V., Vergani, S. D., Vidadi, Z., Xu, D., Wang, L. T., Wang, X. F., Winters, J. M., Zhang, X. L., Zhu, Z., Sub GRASP, Gravitational and Subatomic Physics (GRASP), Hussenot-Desenonges, T., Wouters, T., Guessoum, N., Abdi, I., Abulwfa, A., Adami, C., Agüí Fernández, J. F., Ahumada, T., Aivazyan, V., Akl, D., Anand, S., Andrade, C. M., Antier, S., Ata, S. A., D'Avanzo, P., Azzam, Y. A., Baransky, A., Basa, S., Blazek, M., Bendjoya, P., Beradze, S., Boumis, P., Bremer, M., Brivio, R., Buat, V., Bulla, M., Burkhonov, O., Burns, E., Cenko, S. B., Coughlin, M. W., Corradi, W., Daigne, F., Dietrich, T., Dornic, D., Ducoin, J. G., Duverne, P. A., Elhosseiny, E. G., Elnagahy, F. I., El-Sadek, M. A., Ferro, M., Le Floc'H, E., Freeberg, M., Fynbo, J. P.U., Götz, D., Gurbanov, E., Hamed, G. M., Hasanov, E., Healy, B. F., Heintz, K. E., Hello, P., Inasaridze, R., Iskandar, A., Ismailov, N., Izzo, L., Jhawar, S., Jegou du Laz, T., Kamel, T. M., Karpov, S., Klotz, A., Koulouridis, E., Kuin, N. P., Kochiashvili, N., Leonini, S., Lu, K. X., Malesani, D. B., Mašek, M., Mao, J., Melandri, A., Mihov, B. M., Natsvlishvili, R., Navarete, F., Nedora, V., Nicolas, J., Odeh, M., Palmerio, J., Pang, P. T.H., De Pasquale, M., Peng, H. W., Pormente, S., Peloton, J., Pradier, T., Pyshna, O., Rajabov, Y., Rakotondrainibe, N. A., Rivet, J. P., Rousselot, L., Saccardi, A., Sasaki, N., Schneider, B., Serrau, M., Shokry, A., Slavcheva-Mihova, L., Simon, A., Sokoliuk, O., Srinivasaragavan, G., Strausbaugh, R., Takey, A., Tanvir, N. R., Thöne, C. C., Tillayev, Y., Tosta e Melo, I., Turpin, D., de Ugarte Postigo, A., Vasylenko, V., Vergani, S. D., Vidadi, Z., Xu, D., Wang, L. T., Wang, X. F., Winters, J. M., Zhang, X. L., and Zhu, Z.

Published
2024

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