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Recent advances in Artificial Intelligence (AI) have brought society closer to the long-held dream of creating machines to help with both common and complex tasks and functions. From recommending movies to detecting disease in its earliest stages, AI has become an aspect of daily life many people accept without scrutiny. Despite its functionality and promise, AI has inherent security risks that users should understand and programmers must be trained to address. The ICE (integrity, confidentiality, and equity) cybersecurity labs developed by a team of cybersecurity researchers addresses these vulnerabilities to AI models through a series of hands-on, inquiry-based labs. Through experimenting with and manipulating data models, students can experience firsthand how adversarial samples and bias can degrade the integrity, confidentiality, and equity of deep learning neural networks, as well as implement security measures to mitigate these vulnerabilities. This article addresses the pedagogical approach underpinning the ICE labs, and discusses both sample activities and technological considerations for teachers who want to implement these labs with their students.

Due to the collision-shift effect, helium permeation into the vapor cell causes a time-dependent frequency drift in rubidium atomic clock. To quantify this shift, a cylindrical vapor cell with dimensions of 1.8 cm in diameter, 1.6 cm in height, and 1 mm in thickness, operating at a temperature of 65 ℃, is selected for analysis. Numerical methods are employed to simulate the temporal variation of helium gas pressure within atomic vapor cells composed of Pyrex (Corning 7740) and low helium-permeable aluminosilicate (Corning 1720). The results of the calculations indicate that for Pyrex vapor cells, after 12 years of operation, the drift rate attributable to helium permeation decreases to less than 1.0×10-14/day. In contrast, the frequency drift rate due to helium permeation in aluminosilicate vapor cell rubidium atomical clocks remains below 3.0×10-17/day throughout their operational lifetime, rendering its contribution to the drift rate negligible. This computational approach is also applicable to the investigation of the permeation processes of other gaseous species in various glass materials.

[Objective] To compare the applicability of terrain change monitoring algorithms in the pisha sandstone areas of the loess plateau. [Methods] A branch gully Telagouagou Huangfuchuan was taken as the research object, including digital elevation model of difference (DoD), cloud to cloud (C2C), cloud to mesh (C2M), and multiscale model to model cloud comparison (M3C2). Point cloud data employed to operate the four algorithms were produced using the SfM technique based on images acquired by UAV between July 2022 and March 2023. The impact of point density changes in the accuracy of the employed algorithms was also investigated. [Results] (1) All four algorithms were capable of effectively monitoring large surface changes. Among them, the M3C2 algorithm performed the best with the highest accuracy (R2=0.953, p

Abstract Background Cognitive dysfunction is one of the leading causes of disability and dependence in older adults and is a major economic burden on the public health system. The aim of this study was to investigate the risk factors for cognitive dysfunction and their predictive value in older adults in Northwest China. Methods A cross-sectional study was conducted using a multistage sampling method. The questionnaires were distributed through the Elderly Disability Monitoring Platform to older adults aged 60 years and above in Northwest China, who were divided into cognitive dysfunction and normal cognitive function groups. In addition to univariate analyses, logistic regression and decision tree modelling were used to construct a model to identify factors that can predict the occurrence of cognitive dysfunction in older adults. Results A total of 12,494 valid questionnaires were collected, including 2617 from participants in the cognitive dysfunction group and 9877 from participants in the normal cognitive function group. Univariate analysis revealed that ethnicity, BMI, age, educational attainment, marital status, type of residence, residency status, current work status, main economic source, type of chronic disease, long-term use of medication, alcohol consumption, participation in social activities, exercise status, social support, total scores on the Balanced Test Assessment, total scores on the Gait Speed Assessment total score, and activities of daily living (ADL) were significantly different between the two groups (all P

Primulina serrulata is a valuable ornamental herb with rosette leaves and vibrant flowers. Some leaves of this species exhibit a bright and distinct white color along the upper veins, enhancing their ornamental value, while others are less white or entirely green. This variation is observed in adult leaves from natural habitats and among young leaves from seedlings grown in the laboratory. TMT-labeled proteomics technology was used to study the protein-level biogenesis of white-veined (WV) P. serrulata leaves. Our objective was to offer novel insight into the breeding of WV plants. Chlorophyll (Chl) content was significantly lower in the WV group than in the control group. Out of 6261 proteins identified, a mere 69 met the criteria for differentially expressed proteins (DEPs) after stringent screening for subsequent analyses. Among these DEPs, there were 44 proteins that exhibited downregulation and 25 that were upregulated in the WV plants. Some DEPs associated with chloroplasts and Chl biosynthesis were downregulated, leading to the absence of green coloration. Concurrently, Gene Ontology enrichment analysis further emphasized an insufficiency of magnesium, the key element in Chl biosynthesis. Many DEPs associated with abiotic or biotic stressors were downregulated, suggesting an overall weakening of stress resistance with certain compensatory mechanisms. Similarly, many DEPs related to modifying biomacromolecules were downregulated, possibly affected by the decrease in proteins involved in photosynthesis and stress resistance. Some DEPs containing iron were upregulated, indicating that iron is mainly used to synthesize heme and ferritin rather than Chl. Additionally, several DEPs related to sulfur or sulfate were upregulated, suggesting strengthened respiration. Expansin-A4 and pectinesterase were upregulated, coinciding with the emergence of a rough and bright surface in the white area of leaves, indicative of the elongation and gelation processes in the cell walls. These findings provide new insight for future studies to explore the mechanism of color formation in WV leaves.

【Objective】 Pumping groundwater for irrigation over the past 40 years in most regions in northern China has resulted in groundwater table falling. To alleviate the continued deterioration of groundwater-induced ecosystems, most regions have started to reduce groundwater extraction for irrigation by slightly compromising some crop yields. The purpose of this paper is to analyze its efficacy. 【Method】 Our analysis was based on Shijiazhuang plain in Hebei province. We established a groundwater flow model using the GMS. The schemes for groundwater-limited irrigation of winter wheat, with the associated yield reduction not dropping by more than 20%, were optimized by the simulation model under different precipitations. Meanwhile, the selected schemes for groundwater-limited irrigation were also simulated and predicted. 【Result】 The average shallow groundwater table in most regions begins to rise after the groundwater-limited irrigation was implemented, and the average annual rise in regional shallow groundwater table is 0.17 m. However, the table of deep groundwater continued to drop. In addition, the groundwater storage in the region has changed from decrease to increase, with the total storage in the shallow and deep aquifers increasing from 2019 to 2028 at a rate of 1×108 m3/a. The groundwater storage and average shallow groundwater table are increased by 2.1 and 2 times respectively after implementing the limited-groundwater irrigation, compared to simply reducing groundwater exploitation. 【Conclusion】 Liming groundwater-irrigation is effective for groundwater recovery; our results provide a baseline for sustainable utilization of groundwater for agricultural production.

Abstract Nuclear transfer embryonic stem cells (ntESCs) hold enormous promise for individual-specific regenerative medicine. However, the chromatin states of ntESCs remain poorly characterized. In this study, we employed ATAC-seq and Hi-C techniques to explore the chromatin accessibility and three-dimensional (3D) genome organization of ntESCs. The results show that the chromatin accessibility and genome structures of somatic cells are re-arranged to ESC-like states overall in ntESCs, including compartments, topologically associating domains (TADs) and chromatin loops. However, compared to fertilized ESCs (fESCs), ntESCs show some abnormal openness and structures that have not been reprogrammed completely, which impair the differentiation potential of ntESCs. The histone modification H3K9me3 may be involved in abnormal structures in ntESCs, including incorrect compartment switches and incomplete TAD rebuilding. Moreover, ntESCs and iPSCs show high similarity in 3D genome structures, while a few differences are detected due to different somatic cell origins and reprogramming mechanisms. Through systematic analyses, our study provides a global view of chromatin accessibility and 3D genome organization in ntESCs, which can further facilitate the understanding of the similarities and differences between ntESCs and fESCs.

The newly discovered Paraphlomis youyangensis, native to southeastern Chongqing, China, is introduced to the scientific community. This species exhibits similarities in floral structure to P. kuankuoshuiensis but is distinguishable by several discrete features, such as less pronounced rhizomes (<0.5 vs. 2-4 cm), elongated stolons (present vs. absent), smaller leaf blades (1.8-5.5 x 1.2-3.1 vs. 10-37 x 3-8 cm), leaf margins (shallowly repand and mucronulate vs. serrulate), and shorter bracteoles (1.2-4 vs. ca. 5 mm). Phylogenetic assessments based on two nuclear genes and three chloroplast genes indicated that P. youyangensis has a closer evolutionary relationship with P. yingdeensis but is differentiated from the latter by long stolons, smaller leaf blades (vs. 6.2-16.5 x 4-11.5 cm), leaf margins (vs. crenate-serrate), and notably shorter bracteoles (vs. 7-8 mm). [ABSTRACT FROM AUTHOR]

Background • Lupus nephritis (LN), caused by Systemic lupus erythematosus, is a chronic autoimmune renal disease and a key risk factor for morbidity and fatality involving 50% damage to the kidney. LN is associated with aberrant functioning of the immune system, characterized by increased systemic inflammation, altered lymphocyte count, perivascular infiltration of inflammatory cells, and declined organ functioning. Current Therapies and Limitations • Conventional therapies to LN include high-dose glucocorticoids, immunosuppressants, calcineurin inhibitors, immune boosters, and targeted medicines that improve kidney functioning. However, these drugs triggered severe adverse side effects, and their prolonged usage resulted in drug resistance, accentuating LN complications. TCM in LN Treatment • Hence, safe and functional Traditional Chinese Medicines (TCM), with supporting clinical trials and observational studies, received significant recognition worldwide for the Treatment of LN. In the form of herbal extracts and preparations, TCM proved effective in treating immunodeficient disorders, including LN. Additionally, acupuncture as a TCM appeared promising in reducing LN-induced inflammation and joint pain. Mechanisms and Benefits • The therapeutic mechanisms included reduced antibody generation, pro-inflammatory cytokine release, immune complex formation, complement activation, extracellular matrix damage and proteinuria levels that played vital roles in chronic kidney diseases. They generated immunosuppressive effects by modulating apoptosis, oxidative stress, and inflammatory signaling pathways, such as JAK/STAT, NF-κB, AP-1 and MAPK and their cross-talk in LN and associated renal injury. These therapies improved blood circulation, alleviated renal pathological changes, restored glomerular capillary functioning, and regenerated renal tissues. However, an essential requisite for these therapies for LN included reduced side effects and improved hepatoprotection and detoxification. Clinical studies suggest that TCM formulations may demonstrate therapeutic benefits in alleviating the symptoms of LN, suggesting prospects of combined applications with Western medicine to enhance treatment efficiencies. Overall, TCM is beneficial for treating LN, and may serve as a potential alternative to conventional medicines. [ABSTRACT FROM AUTHOR]