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2. Integrated production and distribution planning for industrial gas supply chains

Author

Lee, Yena

Abstract

With globalisation, the need to have better coordination of production, inventory, and distribution decisions has become increasingly important for industrial gas companies in order to remain competitive in the marketplace. The consolidation of such decisions has an immense impact on the performance of their supply chains and overall profitability. In this thesis, mixed-integer linear programming (MILP) models are proposed to address integrated planning for industrial gas supply chains. The MILP models consider complicating features in the supply chains, e.g., production, inventory management under vendor managed inventory (VMI) system, supply contracts, and transportation schedule. Since solving the integrated problems with this high level of detail requires expensive computational costs when dealing with large-size problems, a hierarchical solution strategy is developed to obtain optimal solutions within reasonable computational times. Next, allocation of transportation resources (i.e., railcars and trucks) is also considered to improve the transportation efficiency and total operating cost simultaneously. Optimisation approaches are proposed based on mixed integer linear fractional programming (MILFP) and multi-objective optimisation (MOO) models. As a solution procedure to the MILFP model, Dinkelbach's algorithm and reformulation-linearisation method are adopted, whereas the ε-constraint method is used for the MOO model. The optimisation problem for the production and inventory routing planning during the COVID-19 pandemic is also addressed. Because the vehicle routing optimisation problem is NP-hard, tailored solution methods are developed based on column generation principles or metaheuristics to tackle larger problem instances. For each of these cases, the applicability of the developed models and solution techniques are tested using real-world case studies of CO2 supply chain planning in the US and O2 supply chain planning in the UK. Furthermore, the capability of models capturing all features mentioned is discussed with the effectiveness of the solution methods in the case studies.

Published
2022

3. Peripheral inflammatory biomarkers define biotypes of bipolar depression

Author

Lee, Yena, Mansur, Rodrigo B, Brietzke, Elisa, Kapogiannis, Dimitrios, Delgado-Peraza, Francheska, Boutilier, Justin J, Chan, Timothy CY, Carmona, Nicole E, Rosenblat, Joshua D, Lee, JungGoo, Maletic, Vladimir, Vinberg, Maj, Suppes, Trisha, Goldstein, Benjamin I, Ravindran, Arun V, Taylor, Valerie H, Chawla, Sahil, Nogueras-Ortiz, Carlos, Cosgrove, Victoria E, Kramer, Nicole E, Ho, Roger, Raison, Charles A, and McIntyre, Roger S

Subjects
Brain Disorders, Clinical Research, Neurosciences, Depression, Mental Health, Biomarkers, Bipolar Disorder, Humans, Infliximab, Insulin Receptor Substrate Proteins, MAP Kinase Signaling System, NF-kappa B, Tumor Necrosis Factor-alpha, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

We identified biologically relevant moderators of response to tumor necrosis factor (TNF)-α inhibitor, infliximab, among 60 individuals with bipolar depression. Data were derived from a 12-week, randomized, placebo-controlled clinical trial secondarily evaluating the efficacy of infliximab on a measure of anhedonia (i.e., Snaith-Hamilton Pleasure Scale). Three inflammatory biotypes were derived from peripheral cytokine measurements using an iterative, machine learning-based approach. Infliximab-randomized participants classified as biotype 3 exhibited lower baseline concentrations of pro- and anti-inflammatory cytokines and soluble TNF receptor-1 and reported greater pro-hedonic improvements, relative to those classified as biotype 1 or 2. Pretreatment biotypes also moderated changes in neuroinflammatory substrates relevant to infliximab's hypothesized mechanism of action. Neuronal origin-enriched extracellular vesicle (NEV) protein concentrations were reduced to two factors using principal axis factoring: phosphorylated nuclear factorκB (p-NFκB), Fas-associated death domain (p-FADD), and IκB kinase (p-IKKα/β) and TNF receptor-1 (TNFR1) comprised factor "NEV1," whereas phosphorylated insulin receptor substrate-1 (p-IRS1), p38 mitogen-activated protein kinase (p-p38), and c-Jun N-terminal kinase (p-JNK) constituted "NEV2". Among infliximab-randomized subjects classified as biotype 3, NEV1 scores were decreased at weeks 2 and 6 and increased at week 12, relative to baseline, and NEV2 scores increased over time. Decreases in NEV1 scores and increases in NEV2 scores were associated with greater reductions in anhedonic symptoms in our classification and regression tree model (r2 = 0.22, RMSE = 0.08). Our findings provide preliminary evidence supporting the hypothesis that the pro-hedonic effects of infliximab require modulation of multiple TNF-α signaling pathways, including NF-κB, IRS1, and MAPK.

Published
2021

21. Ketamine for psychotic depression: An overview of the glutamatergic system and ketamine's mechanisms associated with antidepressant and psychotomimetic effects

Author

Le, Tuyen T., Di Vincenzo, Joshua D., Teopiz, Kayla M., Lee, Yena, Cha, Danielle S., Lui, Leanna M.W., Rodrigues, Nelson B., Ho, Roger C., Cao, Bing, Lin, Kangguang, Nasri, Flora, Gill, Hartej, Lipsitz, Orly, Subramaniapillai, Mehala, Mansur, Rodrigo B., Rosenblat, Joshua D., and McIntyre, Roger S.

Published
2021
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27. The effect of intravenous ketamine on cognitive functions in adults with treatment-resistant major depressive or bipolar disorders: Results from the Canadian rapid treatment center of excellence (CRTCE)

Author

McIntyre, Roger S., Rosenblat, Joshua D., Rodrigues, Nelson B., Lipsitz, Orly, Chen-Li, David, Lee, Jung Goo, Nasri, Flora, Subramaniapillai, Mehala, Kratiuk, Kevin, Wang, Andrew, Gill, Hartej, Mansur, Rodrigo B., Ho, Roger, Lin, Kangguang, and Lee, Yena

Published
2021
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38. Early symptomatic improvements as a predictor of response to repeated-dose intravenous ketamine: Results from the Canadian Rapid Treatment Center of Excellence

Author

Lipsitz, Orly, McIntyre, Roger S., Rodrigues, Nelson B., Kaster, Tyler S., Cha, Danielle S., Brietzke, Elisa, Gill, Hartej, Nasri, Flora, Lin, Kangguang, Subramaniapillai, Mehala, Kratiuk, Kevin, Teopiz, Kayla, Lui, Leanna M.W., Lee, Yena, Ho, Roger, Shekotikhina, Margarita, Mansur, Rodrigo B., and Rosenblat, Joshua D.

Published
2021
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41. Insulin resistance is associated with deficits in hedonic, self-reported cognitive, and psychosocial functional response to antidepressant treatment in individuals with major depressive disorder

Author

Rashidian, Houman, Subramaniapillai, Mehala, Park, Caroline, Lipsitz, Orly, Zuckerman, Hannah, Teopiz, Kayla, Cao, Bing, Lee, Yena, Gill, Hartej, Ho, Roger, Lin, Kangguang, Rodrigues, Nelson B., Iacobucci, Michelle, Rosenblat, Joshua D., McIntyre, Roger S., and Mansur, Rodrigo B.

Published
2021
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45. The Meaningful Change Threshold as Measured by the 16-Item Quick Inventory of Depressive Symptomatology in Adults with Treatment-Resistant Major Depressive and Bipolar Disorder Receiving Intravenous Ketamine

Author

McIntyre, Roger S., Lipsitz, Orly, Lui, Leanna M.W., Rodrigues, Nelson B., Gill, Hartej, Nasri, Flora, Ling, Rui, Teopiz, Kayla M., Ho, Roger C., Subramaniapillai, Mehala, Kratiuk, Kevin, Mansur, Rodrigo B., Jones, Brett D.M., Lee, Yena, and Rosenblat, Joshua D.

Published
2021
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47. Exploring brain insulin resistance in adults with bipolar depression using extracellular vesicles of neuronal origin

Author

Mansur, Rodrigo B., Delgado-Peraza, Francheska, Subramaniapillai, Mehala, Lee, Yena, Iacobucci, Michelle, Nasri, Flora, Rodrigues, Nelson, Rosenblat, Joshua D., Brietzke, Elisa, Cosgrove, Victoria E., Kramer, Nicole E., Suppes, Trisha, Raison, Charles L., Fagiolini, Andrea, Rasgon, Natalie, Chawla, Sahil, Nogueras-Ortiz, Carlos, Kapogiannis, Dimitrios, and McIntyre, Roger S.

Published
2021
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