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Your search keyword '"Hulscher, Jan B. F."' showing total 291 results
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291 results on '"Hulscher, Jan B. F."'

6. High prevalence of non-accidental trauma among deceased children presenting at Level I trauma centers in the Netherlands

Author

Loos, Marie-Louise H. J., Bakx, Roel, Duijst, Wilma L. J. M., Aarts, Francee, de Blaauw, Ivo, Bloemers, Frank W., Ten Bosch, Jan A., Evers, Martina, Greeven, Alexander P. A., Hondius, Marie-Josée, van Hooren, Roland L. J. H., Huisman, Erik, Hulscher, Jan B. F., Keyzer-Dekker, Claudia M. G., Krug, Egbert, Menke, Jack, Naujocks, Tatjana, Reijnders, Udo J. L., de Ridder, Victor A., Spanjersberg, W. Richard, Teeuw, Arianne H., Theeuwes, Hilco P., Vervoort-Steenbakkers, Will, de Vries, Selena, de Wit, Ralph, and van Rijn, Rick R.

Published
2021
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18. Utility of liver and intestinal fatty acid-binding proteins in diagnosing intra-abdominal injury in adult trauma patients

Author

de Jong, Willem J. J., El Moumni, Mostafa, Wendt, Klaus W., Nijsten, Maarten W., Hulscher, Jan B. F., Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Microbes in Health and Disease (MHD), and Center for Liver, Digestive and Metabolic Diseases (CLDM)

Subjects
Adult, FABP, Liver, MARKERS, CONSENT, Humans, Surgery, COMPUTED-TOMOGRAPHY, Abdominal Injuries, Prospective Studies, Fatty Acid-Binding Proteins, Wounds, Nonpenetrating, ABDOMINAL INJURY
Published
2022

23. Additional file 3 of Development of an international core outcome set for treatment trials in necrotizing enterocolitis—a study protocol

Author

Klerk, Daphne H., van Varsseveld, Otis C., Offringa, Martin, Modi, Neena, Lacher, Martin, Zani, Augusto, Pakarinen, Mikko P., Koivusalo, Antti, Jester, Ingo, Spruce, Marie, Derikx, Joep P. M., Bakx, Roel, Ksia, Amine, Vermeulen, Marijn J., Kooi, Elisabeth M. W., and Hulscher, Jan B. F.

Abstract

Additional file 3.

Published
2023
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24. Additional file 1 of Development of an international core outcome set for treatment trials in necrotizing enterocolitis—a study protocol

Author

Klerk, Daphne H., van Varsseveld, Otis C., Offringa, Martin, Modi, Neena, Lacher, Martin, Zani, Augusto, Pakarinen, Mikko P., Koivusalo, Antti, Jester, Ingo, Spruce, Marie, Derikx, Joep P. M., Bakx, Roel, Ksia, Amine, Vermeulen, Marijn J., Kooi, Elisabeth M. W., and Hulscher, Jan B. F.

Abstract

Additional file 1. COS-STAP Checklist.

Published
2023
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25. Choledochal Malformation in Children: Lessons Learned from a Dutch National Study

Author

van den Eijnden, Maria. H. A., de Kleine, Ruben H. J., de Blaauw, Ivo, Peeters, Paul G. J. M., Koot, Bart P. G., Oomen, Matthijs W. N., Sloots, Cornelius E. J., van Gemert, W. G., van der Zee, David C., van Heurn, L. W. E., Verkade, Henkjan J., Wilde, Jim C. H., Hulscher, Jan B. F., and Nederlandse Studiegroep voor Choledochus Cysten/malformaties (NeSCHoC)

Published
2017
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36. Impact of Genotype, Serum Bile Acids, and Surgical Biliary Diversion on Native Liver Survival in FIC1 Deficiency

Author

van Wessel, Daan B. E. Thompson, Richard J. Gonzales, Emmanuel and Jankowska, Irena Shneider, Benjamin L. Sokal, Etienne and Grammatikopoulos, Tassos Kadaristiana, Agustina Jacquemin, Emmanuel Spraul, Anne Lipinski, Patryk Czubkowski, Piotr and Rock, Nathalie Shagrani, Mohammad Broering, Dieter Algoufi, Talal Mazhar, Nejat Nicastro, Emanuele Kelly, Deirdre and Nebbia, Gabriella Arnell, Henrik Fischler, Bjorn Hulscher, Jan B. F. Serranti, Daniele Arikan, Cigdem Debray, Dominique and Lacaille, Florence Goncalves, Cristina Hierro, Loreto and Bartolo, Gema Munoz Mozer-Glassberg, Yael Azaz, Amer and Brecelj, Jernej Dezsofi, Antal Calvo, Pier Luigi and Krebs-Schmitt, Dorothee Hartleif, Steffen van der Woerd, Wendy L. Wang, Jian-She Li, Li-Ting Durmaz, Ozlem Kerkar, Nanda Jorgensen, Marianne Horby Fischer, Ryan and Jimenez-Rivera, Carolina Alam, Seema Cananzi, Mara and Laverdure, Noemie Ferreira, Cristina Targa Ordonez, Felipe and Wang, Heng Sency, Valerie Kim, Kyung Mo Chen, Huey-Ling and Carvalho, Elisa Fabre, Alexandre Bernabeu, Jesus Quintero and Alonso, Estella M. Sokol, Ronald J. Suchy, Frederick J. and Loomes, Kathleen M. McKiernan, Patrick J. Rosenthal, Philip and Turmelle, Yumirle Rao, Girish S. Horslen, Simon Kamath, Binita M. Rogalidou, Maria Karnsakul, Wikrom W. Hansen, Bettina Verkade, Henkjan J. Nat Course Prognosis PFIC Effect B

Abstract

BACKGROUND AND AIMS: Mutations in ATPase phospholipid transporting 8B1 (ATP8B1) can lead to familial intrahepatic cholestasis type 1 (FIC1) deficiency, or progressive familial intrahepatic cholestasis type 1. The rarity of FIC1 deficiency has largely prevented a detailed analysis of its natural history, effects of predicted protein truncating mutations (PPTMs), and possible associations of serum bile acid (sBA) concentrations and surgical biliary diversion (SBD) with long-term outcome. We aimed to provide insights by using the largest genetically defined cohort of patients with FIC1 deficiency to date. APPROACH AND RESULTS: This multicenter, combined retrospective and prospective study included 130 patients with compound heterozygous or homozygous predicted pathogenic ATP8B1 variants. Patients were categorized according to the number of PPTMs (i.e., splice site, frameshift due to deletion or insertion, nonsense, duplication), FIC1-A (n = 67; no PPTMs), FIC1-B (n = 29; one PPTM), or FIC1-C (n = 34; two PPTMs). Survival analysis showed an overall native liver survival (NLS) of 44% at age 18 years. NLS was comparable among FIC1-A, FIC1-B, and FIC1-C (% NLS at age 10 years: 67%, 41%, and 59%, respectively; P = 0.12), despite FIC1-C undergoing SBD less often (% SBD at age 10 years: 65%, 57%, and 45%, respectively; P = 0.03). sBAs at presentation were negatively associated with NLS (NLS at age 10 years, sBAs < 194 mu mol/L: 49% vs. sBAs >= 194 mu mol/L: 15%; P = 0.03). SBD decreased sBAs (230 [125-282] to 74 [11-177] mu mol/L; P = 0.005). SBD (HR 0.55, 95% CI 0.28-1.03, P = 0.06) and post-SBD sBA concentrations < 65 mu mol/L (P = 0.05) tended to be associated with improved NLS. CONCLUSIONS: Less than half of patients with FIC1 deficiency reach adulthood with native liver. The number of PPTMs did not associate with the natural history or prognosis of FIC1 deficiency. sBA concentrations at initial presentation and after SBD provide limited prognostic information on long-term NLS.

Published
2021

45. The Dutch Incidence of Infantile Hypertrophic Pyloric Stenosis and the Influence of Seasons

Author

van den Bunder, Fenne A. I. M., additional, Allema, Jan Hein, additional, Benninga, Marc A., additional, de Blaauw, Ivo, additional, van de Brug, Tim, additional, den Dulk, Marcel, additional, Hulscher, Jan B. F., additional, Keyzer-Dekker, Claudia M. G., additional, Witvliet, Marieke J., additional, van Heurn, Ernest L. W., additional, and Derikx, Joep P. M., additional

Published
2020
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47. In Vitro Evaluation of Pro- and Anticoagulant Drugs in Children with End-Stage Liver Disease Undergoing Liver Transplantation

Author

Werner, Maureen J. M., additional, Adelmeijer, Jelle, additional, de Meijer, Vincent E., additional, de Kleine, Ruben H. J., additional, Scheenstra, René, additional, Bontemps, Sander T. H., additional, Reyntjens, Koen M. E. M., additional, Hulscher, Jan B. F., additional, Porte, Robert J., additional, and Lisman, Ton, additional

Published
2020
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50. Intestinal Oxygenation and Survival After Surgery for Necrotizing Enterocolitis: An Observational Cohort Study.

Author

Kuik, Sara J., van der Heide, Martin, Bruggink, Janneke L. M., Bos, Arend F., Verhagen, A. A. Eduard, Kooi, Elisabeth M. W., and Hulscher, Jan B. F.

Abstract

Objective: To assess whether regional intestinal oxygen saturation (rintSO2) and regional cerebral oxygen saturation (rcSO2) measurements aid in estimating survival of preterm infants after surgery for NEC. Summary of Background Data: Predicting survival after surgery for NEC is difficult yet of the utmost importance for counseling parents. Methods: We retrospectively studied prospectively collected data of preterm infants with surgical NEC who had available rintSO2 and rcSO2 values measured via near-infrared spectroscopy 0–24 hours preoperatively. We calculated mean rintSO2 and rcSO2 for 60–120 minutes for each infant. We analyzed whether preoperative rintSO2 and rcSO2 differed between survivors and non-survivors, determined cut-off points, and assessed the added value to clinical variables. Results: We included 22 infants, median gestational age 26.9 weeks [interquartile range (IQR): 26.3–28.4], median birth weight 1088 g [IQR: 730–1178]. Eleven infants died postoperatively. Preoperative rintSO2, but not rcSO2, was higher in survivors than in non-survivors [median: 63% (IQR: 42–68) vs 29% (IQR: 21–43), P < 0.01), with odds ratio for survival 4.1 (95% confidence interval, 1.2–13.9, P = 0.02) per 10% higher rintSO2. All infants with rintSO2 values of >53% survived, whereas all infants with rintSO2 <35% died. Median C-reactive protein [138 mg/L (IQR: 83–179) vs 73 mg/L (IQR: 12–98), P < 0.01), lactate [1.1 mmol/L (IQR: 1.0–1.6) vs 4.6 mmol/L (IQR: 2.8–8.0), P < 0.01], and fraction of inspired oxygen [25% (IQR: 21–31) vs 42% (IQR: 30–80), P < 0.01] differed between survivors and non-survivors. Only rintSO2 remained significant in the multiple regression model. Conclusions: Measuring rintSO2, but not rcSO2, seems of added value to clinical variables in estimating survival of preterm infants after surgery for NEC. This may help clinicians in deciding whether surgery is feasible and to better counsel parents about their infants' chances of survival. [ABSTRACT FROM AUTHOR]

Published
2022
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