1. Predicting stringent QuantiFERON-TB Gold Plus conversions in contacts of tuberculosis patients
- Author
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Pan, Sheng-Wei, Catanzaro, Donald G, Seifert, Marva, Syed, Rehan R, Hillery, Naomi, Ho, Mei-Lin, Crudu, Valeriu, Tudor, Elena, Ciobanu, Nelly, Codreanu, Alexandru, Catanzaro, Antonino, and Rodwell, Timothy C
- Subjects
Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Infectious Diseases ,Rare Diseases ,Lung ,Emerging Infectious Diseases ,Biodefense ,Tuberculosis ,Infection ,Good Health and Well Being ,Humans ,Latent Tuberculosis ,Interferon-gamma Release Tests ,Interferon-gamma ,Lung Diseases ,Mycobacterium tuberculosis ,Tuberculin Test ,Interferon-gamma release assay ,QuantiFERON-TB Gold plus ,Stringent conversion ,Tuberculosis contacts ,Immunology ,Medical Microbiology ,Microbiology ,Clinical sciences - Abstract
ObjectivesTo assess associations between disease severity in index TB patients and QuantiFERON-TB Gold Plus (QFT-Plus) results in contacts, and predictors for QFT-Plus conversion in contacts over 6-12 months.MethodsTB patients (n = 295) and the contacts (n = 1051) were enrolled during 2018-2021 with QFT-Plus performed at baseline and months 6 and 12. A strong CD8 response was defined as TB2 interferon gamma (IFN-γ) response minus TB1 >0.6 IU/ml and stringent conversion as change from QFT-plus negative to high-positive QFT-Plus (TB1 or TB2 IFN-γ responses >0.7 IU/ml).ResultsContacts with index TB patients with sputum smear >1+ was associated with positive QFT-Plus compared to those without (p
- Published
- 2023