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471 results on '"Hibi, Hideharu"'

16. Ferroptosis induced by plasma‐activated Ringer's lactate solution prevents oral cancer progression.

Author

Sato, Kotaro, Yang, Ming, Nakamura, Kae, Tanaka, Hiromasa, Hori, Masaru, Nishio, Miki, Suzuki, Akira, Hibi, Hideharu, and Toyokuni, Shinya

Subjects
SQUAMOUS cell carcinoma, IRON, IRON in the body, FLOW cytometry, IN vitro studies, PHYSIOLOGIC salines, MOUTH tumors, CANCER invasiveness, RESEARCH funding, BONE growth, ELECTRON microscopy, IN vivo studies, DESCRIPTIVE statistics, CELL lines, MICE, KERATINOCYTES, FIBROBLASTS, GENE expression, CELL death, ANIMAL experimentation, OXIDOREDUCTASES, CELL survival, DISEASE progression, IMMUNOBLOTTING
Abstract

Objective: This study aimed to investigate the effect of plasma‐activated Ringer's lactate solution (PAL) on oral squamous cell carcinoma (OSCC) cells and carcinogenic processes with a particular focus on iron and collagenous matrix formation. Materials and Methods: We used three OSCC cell lines, one keratinocyte cell line, and two fibroblast lines, and cell viability assays, immunoblotting, flow cytometry, and transmission electron microscopy were performed to evaluate the effect and type of cell death. The effect of PAL treatment on lysyl oxidase (LOX) expression was investigated in vitro and in vivo. Tamoxifen‐inducible Mob1a/b double‐knockout mice were used for the in vivo experiment. Results: PAL killed OSCC cells more effectively than the control nontumorous cells and suppressed cell migration and invasion. Ferroptosis occurred and the protein level of LOX was downregulated in cancer cells in vitro and in vivo. Additionally, PAL improved the survival rate of mice and suppressed collagenous matrix formation. Conclusions: We demonstrated that PAL specifically kills OSCC cells and that ferroptosis occurs in vitro and in vivo. Furthermore, PAL can prevent carcinogenesis and improve the survival rate of oral cancer, especially tongue cancer, by changing collagenous matrix formation via LOX suppression. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Clinical course of liver injury induced by immune checkpoint inhibitors in patients with advanced malignancies

Author

Ito, Takanori, Ishigami, Masatoshi, Yamamoto, Takafumi, Mizuno, Kazuyuki, Yamamoto, Kenta, Imai, Norihiro, Ishizu, Yoji, Honda, Takashi, Kawashima, Hiroki, Yasuda, Satoshi, Toyoda, Hidenori, Yokota, Kenji, Hase, Tetsunari, Nishio, Naoki, Maeda, Osamu, Kato, Masashi, Hashimoto, Naozumi, Hibi, Hideharu, Kodera, Yasuhiro, Sone, Michihiko, Ando, Yuichi, Akiyama, Masashi, Shimoyama, Yoshie, and Fujishiro, Mitsuhiro

Published
2021
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19. Exposure of low-temperature plasma after vaccination in tongue promotes systemic IgM induction against spike protein of SARS-CoV-2

Author

Sato, Kotaro, Fujii, Kouki, Tanaka, Hiromasa, Hori, Masaru, Hibi, Hideharu, Toyokuni, Shinya, Sato, Kotaro, Fujii, Kouki, Tanaka, Hiromasa, Hori, Masaru, Hibi, Hideharu, and Toyokuni, Shinya

Abstract

COVID-19 has been pandemic since 2020 with persistent generation of new variants. Cellular receptor for SARS-CoV-2 is angiotensin-converting enzyme 2 (ACE2), where transmembrane serine protease-2 (TMPRSS2) is essential for viral internalization. We recently reported abundant expression of ACE2 and TMPRSS2 in the oral cavity of humans and mice. Therefore, oral cavity may work for COVID-19 infection gates. Here we undertook to evaluate whether vaccination in the tongue harbors any merit in comparison to subcutaneous injection. Low-temperature plasma (LTP) is the fourth physical state of matters with ionization above gas but at body temperature. LTP provides complex chemistry, eventually supplying oxidative and/or nitrosative stress on the interface. LTP-associated cellular death has been reported to cause apoptosis and/or ferroptosis. However, there is few data available on immunogenicity retention after LTP exposure. We therefore studied the effect of LTP exposure after the injection of keyhole limpet hemocyanin (KLH) or spike 2 protein of SARS-CoV-2 to the tongue of six-week-old male BALB/c mice, compared to subcutaneous vaccination. Whereas LTP did not change the expression of ACE2 and TMPRSS2 in the tongue, repeated LTP exposure after tongue vaccination significantly promoted systemic and specific IgM production at day 11. In contrast, repeated LTP exposure after subcutaneous vaccination of KLH decreased systemic IgM production. Of note, tongue injection produced significantly higher titer of IgM and IgG in the case of KLH. In conclusion, LTP significantly reinforced humoral immunity by IgM after tongue injection. Vaccination to the tongue can be a novel strategy to acquire immediate immunity.

Published
2024

21. Real world data of liver injury induced by immune checkpoint inhibitors in Japanese patients with advanced malignancies

Author

Mizuno, Kazuyuki, Ito, Takanori, Ishigami, Masatoshi, Ishizu, Yoji, Kuzuya, Teiji, Honda, Takashi, Kawashima, Hiroki, Inukai, Yosuke, Toyoda, Hidenori, Yokota, Kenji, Hase, Tetsunari, Maeda, Osamu, Kiyoi, Hitoshi, Nagino, Masato, Hibi, Hideharu, Kodera, Yasuhiro, Fujimoto, Yasushi, Sone, Michihiko, Gotoh, Momokazu, Ando, Yuichi, Akiyama, Masashi, Hasegawa, Yoshinori, and Fujishiro, Mitsuhiro

Published
2020
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22. Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study

Author

Okada, Norio, Iwama, Shintaro, Okuji, Takayuki, Kobayashi, Tomoko, Yasuda, Yoshinori, Wada, Eri, Onoue, Takeshi, Goto, Motomitsu, Sugiyama, Mariko, Tsunekawa, Taku, Takagi, Hiroshi, Hagiwara, Daisuke, Ito, Yoshihiro, Suga, Hidetaka, Banno, Ryoichi, Hase, Tetsunari, Morise, Masahiro, Kanda, Mitsuro, Yokota, Kenji, Hashimoto, Naozumi, Ando, Masahiko, Fujimoto, Yasushi, Nagino, Masato, Kodera, Yasuhiro, Fujishiro, Mitsuhiro, Hibi, Hideharu, Sone, Michihiko, Kiyoi, Hitoshi, Gotoh, Momokazu, Ando, Yuichi, Akiyama, Masashi, Hasegawa, Yoshinori, and Arima, Hiroshi

Published
2020
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26. Positive impact of perioperative oral management on the risk of surgical site infections after abdominal surgery: Sixteen universities in Japan

Author

Shimane, Tetsu, primary, Koike, Kazuyuki, additional, Fujita, Shigeyuki, additional, Kurita, Hiroshi, additional, Isomura, Emiko Tanaka, additional, Chikazu, Daichi, additional, Kanno, Naomi, additional, Sasaki, Keiichi, additional, Hino, Satoshi, additional, Hibi, Hideharu, additional, Koyama, Takahiro, additional, Nakamura, Seiji, additional, Nomura, Takeshi, additional, Mori, Yoshiyuki, additional, Tojyo, Itaru, additional, Yamamoto, Toshiro, additional, Yamamori, Iku, additional, Aota, Keiko, additional, and Tanzawa, Hideki, additional

Published
2023
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29. 乳歯歯髄幹細胞培養上清は分泌型Frizzled関連タンパク1を介してマウス下顎頭軟骨細胞における炎症関連分子の発現を部分的に変化させる

Author

Xia, Linze, Kano, Fumiya, Hashimoto, Noboru, Ding, Cheng, Xu, Yang, Hibi, Hideharu, Iwasaki, Tomonori, Tanaka, Eiji, and Yamamoto, Akihito

Subjects
secretome, chondrocyte, SFRP1, Dental pulp stem cell, anti-inflammation
Abstract

Intravenous administration of conditioned medium from stem cells of human exfoliated deciduous teeth (SHED-CM) effectively restores mechanically injured osteochondral tissues in mouse temporomandibular joint osteoarthritis. However, the underlying therapeutic mechanisms remain elusive. Here, we investigated the direct therapeutic effects of SHED-CM on inflamed primary condylar chondrocytes in vitro. Immunofluorescence staining revealed that interleukin-1β-stimulated chondrocytes showed increased expression of the catabolic marker inducible nitric oxide synthase (iNOS) and reduced expression of the anabolic marker aggrecan (ACAN). We found that SHED-CM treatment, but not conditioned medium from bone marrow mesenchymal stem cells (BMSC-CM), effectively suppressed iNOS expression and elevated ACAN levels, indicating that SHED-CM converted the catabolic phenotype of inflamed chondrocytes to an anabolic phenotype. Liquid chromatography with tandem mass spectrometry analysis of SHED-CM and BMSC-CM identified eight proteins enriched in SHED-CM that are related to anti-inflammatory and/or chondrogenic processes. Of these proteins, the Wnt signal inhibitor secreted frizzled-related protein 1 (SFRP1) was the most abundantly enriched in SHED-CM. We found that treatment with the selective SFRP1 inhibitor WAY-316606 abolished the anti-catabolic and pro-anabolic effects of SHED-CM. Collectively, our study suggests that SHED-CM directly suppresses catabolism and promotes anabolic responses of inflamed primary condylar chondrocytes, which partially rely on SFRP1 function in SHED-CM. The direct action of SHED-CM may be useful to treat inflammatory cartilage diseases.

Published
2023

30. Comparison study of the Le Fort I osteotomy using 2- and 4-plate fixation

Author

Fujio, Masahito, Sayo, Akira, Ogisu, Kota, Chang, Qi, Tsuboi, Makoto, and Hibi, Hideharu

Subjects
Le Fort I osteotomy, relapse, orthognathic surgery, skeletal stability
Abstract

This study was conducted to evaluate the postsurgical stability of Le Fort I osteotomy using zygomatic buttress internal fixation alone with no piriform aperture internal fixation. Patients with maxillary retrognathia and mandibular prognathism underwent the Le Fort I osteotomy with a bilateral sagittal split ramus osteotomy. In group I, fixation was accomplished using titanium plate and screws placed at the piriform aperture and the zygomatic buttress (4 plates). In group II, fixation was accomplished using titanium plate and screws placed at the zygomatic buttress (2 plates). Lateral cephalometric radiographs were taken preoperatively (T1), immediately after surgery (T2), and at 6 months to 1 year (T3) to evaluate skeletal movement. In total, 32 patients were included in this study. None of the patients had wound infection, dehiscence, bone fragment instability, and long-term malocclusion. Regarding point A and the posterior nasal spine (PNS), vertical and horizontal relapse in groups I and II did not differ significantly. In most hospitals, the maxilla was fixed using four plates (piriform aperture and zygomatic buttress); however, within the limitations of the study, the choice of the number of plates for osteosynthesis following Le Fort I osteotomy and repositioning of the maxilla can be left to the discretion of the surgeon without putting the patients at risk for increased relapse by careful intraoperative management.

Published
2023

33. Efficacy of semi-solidification of enteral nutrients for postoperative nutritional management with a nasogastric tube

Author

Okabe, Kazuto, Kaneko, Ryuji, Kawai, Takamasa, Ohta, Yuya, Ohara, Go, and Hibi, Hideharu

Subjects
enteral nutrients, nutritional management, nasogastric tube, semi-solidification
Abstract

Postoperative nutritional management with a nasogastric tube is often used to prevent malnutrition after oral and maxillofacial surgery. However, enteral nutrients (EN) may cause various complications due to their liquid formulation. In this study, we retrospectively evaluated the efficacy of semi-solid EN with a xanthan gum thickener through a nasogastric tube and examined patients’ complications, nutritional status, and quality of life. We established two groups: an L group (n=20) to which we administered liquid EN, and an SS group (n=20) to which we administered semi-solidified EN. The primary outcome was the occurrence of gastrointestinal complications. The secondary outcome was a change in nutritional status based on body weight and controlling nutritional status. The other outcome was the improvement in the patients’ quality of life, assessed by the administration time. During nutritional management with a nasogastric tube, the median daily administration time in the L group was 9.0 hours, and 9 patients experienced diarrhea. In the SS group, the median daily feeding time was 2.3 hours, and only 2 patients experienced diarrhea. Both groups exhibited a decrease in body weight while controlling nutritional status scores were maintained. Semi-solidification of EN may be useful for postoperative nutritional management after oral and maxillofacial surgery by reducing complications, maintaining nutritional status, and shortening administration time.

Published
2022

39. Hyperthermia maintains death receptor expression and promotes TRAIL‐induced apoptosis.

Author

Ohara, Go, Okabe, Kazuto, Toyama, Naoto, Ohta, Yuya, Xinman, Song, Ichimura, Norihisa, Sato, Kotaro, Urata, Yusuke, and Hibi, Hideharu

Subjects
DEATH receptors, FEVER, TRAIL protein, APOPTOSIS, SQUAMOUS cell carcinoma
Abstract

Background: Tumor necrosis factor‐related apoptosis‐inducing ligand activates apoptotic pathways and could potentially be used in anticancer treatments. However, oral squamous cell carcinoma cells are known to be resistant to tumor necrosis factor‐related apoptosis‐inducing ligand‐induced cell death. It has been previously reported that hyperthermia upregulates tumor necrosis factor‐related apoptosis‐inducing ligand‐induced apoptosis in other cancers. As such, we evaluated whether hyperthermia upregulates tumor necrosis factor‐related apoptosis‐inducing ligand‐mediated apoptosis in a tumor necrosis factor‐related apoptosis‐inducing ligand‐resistant oral squamous cell carcinoma cell line. Methods: The oral squamous cell carcinoma cell line HSC3 was cultured and divided into hyperthermia and control groups. We investigated the antitumor effects of recombinant human tumor necrosis factor‐related apoptosis‐inducing ligand using cell proliferation and apoptosis assays. Additionally, we measured death receptor 4 and 5 levels, and determined death receptor ubiquitination status, as well as E3 ubiquitin ligase targeting of death receptor in both hyperthermia and control groups before recombinant human tumor necrosis factor‐related apoptosis‐inducing ligand administration. Results: Treatment with recombinant human tumor necrosis factor‐related apoptosis‐inducing ligand produced greater inhibitory effects in the hyperthermia group than in the control group. Moreover, death receptor protein expression in the hyperthermia group was upregulated on the cell surface (and overall), although death receptor mRNA was downregulated. The half‐life of death receptor was several hours longer in the hyperthermia group; concomitantly, E3 ubiquitin ligase expression and death receptor ubiquitination were downregulated in this group. Conclusion: Our findings suggested that hyperthermia enhances apoptotic signaling by tumor necrosis factor‐related apoptosis‐inducing ligand via the suppression of death receptor ubiquitination, which upregulates death receptor expression. These data suggest that the combination of hyperthermia and tumor necrosis factor‐related apoptosis‐inducing ligand has implications in developing a novel treatment strategy for oral squamous cell carcinoma. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Third molar pericoronitis in neutropenia

Author

Kano Fumiya, Ichimura Norihisa, Wakayama Yukiko, Okabe Kazuto, Sakakura Hiroki, and Hibi Hideharu

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

We report the case of a 40 year-old woman who presented third molar pericoronitis in neutropenia. she had undergone extraction of the right third mandibular molar. This may have been due to an infection in the extraction socket or part of the crown. There was no inflammation seen after transplant of umbilical cord blood. Keywords: Neutropenia, Pericoronitis, Oral infection

Published
2018
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45. Psychological impact on patients with oral cancer before undergoing resection and free flap reconstruction surgery

Author

Yamaguchi, Satoshi, primary, Kaminogo, Kento, additional, Tokura, Tatsuya, additional, Kimura, Hiroyuki, additional, Kishi, Shinichi, additional, Yamamoto, Noriyuki, additional, Ichimura, Norihisa, additional, Toyama, Naoto, additional, Koma, Yoshiro, additional, Kouyama, Naoka, additional, Ozaki, Norio, additional, and Hibi, Hideharu, additional

Published
2022
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