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7. Research progress on antibody-mediated pure red cell aplasia in chronic kidney disease

Author

You Xiaoe, Ma Hualin, Wang Zhen, Zhang Xinzhou, Guo Baochun

Subjects
erythropoietin, pure red cell aplasia, chronic kidney disease, roxadustat, Medicine
Abstract

Erythropoietin and its analogues are the most effective drugs for the treatment of anemia caused by chronic kidney disease （CKD），malignant tumors and chemotherapy，autoimmune disorders，and malnutrition，etc. However，partial patients，especially CKD patients，can generate neutralizing antibody after use of erythropoiesis-stimulating agents，thereby leading to pure red cell aplasia （PRCA） and severely affecting disease condition and clinical prognosis. Full understanding of antibody-induced PRCA contributes to delivering early diagnosis，appropriate examinations and effective treatment，and enhancing clinical prognosis of CKD patients. In this article，research progress upon antibody-induced PRCA in CKD patients was systematically reviewed.

Published
2023
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14. Microwave-assisted alcoholysis of silicone rubber waste with geraniol for effective elastomer damping

Author

Zou, Zhuanglei, An, Xinglong, Li, Li, Fan, Xiaopeng, Zhou, Yongyan, Wu, Siwu, and Guo, Baochun

Subjects
Crosslinked polymers -- Analysis, Silicones -- Identification and classification -- Mechanical properties, Monoterpenes -- Usage, Chemical reactions -- Methods -- Analysis, Rubber -- Identification and classification -- Mechanical properties, Engineering and manufacturing industries, Science and technology
Abstract

The first step in the mainstream end-of-life management of discarded siliconerubber-based composite insulators involves grinding and modification of them into fine silicone rubber powders (SRPs). However, significant knowledge gaps have prevented researchers from developing direct efficient surface treatments for SRPs that do not involve time-consuming and multi-step processes. Herein, we report a straightforward method for the efficient modification of discarded SRPs through a microwave-assisted alcoholysis process. Specifically, the siloxane moieties of the SRPs were cleaved using nucleophilic geraniol as a modifier, thereby facilitating the introduction of abundant alkoxysilyl groups on SRPs surface. During sulfur crosslinking, the intrachain vinyl functionalities of the modified SRPs co-crosslinked with the rubber matrix via sulfur bridges, thereby improving the dispersion state of the SRPs and the interfacial adhesion between the SRPs and the rubber matrix. Accordingly, even for a high SRP loading (200 phr, parts per hundreds of gum), the mechanical performance of the resulting systems, and in particular the tensile strength and extensibility were significantly higher than those of the rubber matrix. Moreover, the interfacial adhesion of the resulting systems was improved, and the resulting systems presented remarkable damping performance (tan [delta] [greater than or equal to] 0.3) over a broad temperature range ([greater than or equal to] 80[degrees]C). KEYWORDS damping performance, diene rubber, discarded silicone rubber, microwave-assisted alcoholysis, surface modification, 1 | INTRODUCTION Waste disposal management is an intractable issue in today's society. The use of waste materials as fillers is a practical and cost-saving method for polymer reinforcement and [...]

Published
2022
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47. PVA@tea tree oil‐emulsion core–shell microfiber membranes for extending the shelf life of fruits.

Author

Dai, Tianliang, Liu, Ya, Wang, Lina, Yao, Juming, Zhu, Guocheng, Guo, Baochun, Militk, Jiri, Kremenakova, Dana, and Zhang, Ming

Abstract

In this work, a temperature‐regulating and antimicrobial–antioxidant fiber membrane was fabricated using coaxial electrospinning technology. The tea tree oil (TTO) emulsion used as the core solution, polyvinyl alcohol (PVA) as the shell solution for coaxial electrospinning, has been demonstrated. Compared with the original PVA fibers, the average diameter of the fibers is increased after coaxial electrospinning, and the diameter increases with the core flow rate. The diameters corresponding to core flow rates of 0.05, 0.1, and 0.15 mL/h are 561, 597, and 849 nm, respectively. Via in vitro release experiment demonstrated that the quantity of TTO released from the composite membrane increased with the elevation of temperature. The inclusions TTO and polyethylene glycol give the film excellent antibacterial–antioxidant properties and a delayed thermal response. More intriguingly, core–shell fiber membranes containing TTO in the core part are effective in slowing down the formation of oxidation spots on the surface of banana compared with pure PVA membranes. Seven days after wrapping bananas with different membranes, the surface of banana in pure PVA film was full of oxidized spots, whereas banana in PVA core–shell fibers showed only one obvious spot. [ABSTRACT FROM AUTHOR]

Published
2024
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