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Background/Objectives: Radiculopathy leads to pain, consequently reducing patient's quality of life (QoL). Research indicates that certain nucleotides, such as cytidine and uridine, along with vitamins B1 and B12, may help alleviate pain and enhance QoL. This study assessed the impact of adding a supplement containing cytidine and uridine nucleotides and vitamins B1 and B12, alongside standard treatment, on radiculopathy-associated pain. Methods: A multicenter, prospective, two-cohort, randomized, open-label study was conducted. The control group received standard treatment, while the experimental group received standard treatment plus the supplement. The primary endpoint was pain reduction measured by a Visual Analog Scale (VAS). Secondary endpoints included functional improvement (Roland Morris questionnaire), clinical improvement (Clinical Global Impression [CGI] scale), and QoL improvement (EQ-5D-5L questionnaire). Results: A total of 122 patients were included from 17 centers across Spain. Both groups showed pain improvement, but the VAS reduction (control: 24.58 vs. experimental: 31.35) was not statistically significant. The Roland Morris score decreased significantly in the experimental group (estimate: −1.70, 95% CI −3.29 to −0.10; p = 0.038), and these patients were 5 times more likely to progress to a better CGI category (OR = 0.20, 95% CI 0.07 to 0.57; p = 0.003). No significant differences were observed in EQ-5D-5L scores or analgesic consumption. Conclusions: The addition of supplemental pyrimidine nucleotides and vitamins B1 and B12 to standard of care treatment improved radiculopathy functional and clinical outcomes. Regarding pain, however, although there was a numerical improvement, it did not reach statistical significance. [ABSTRACT FROM AUTHOR]

Presents a study which examined the temperature variation of energy gaps and deformation potentials in CuGa(S[subz]Se[sub1-z])[sub2] semiconductor alloys. Preparation of the samples; Results of the study; Information on deformation potentials.

The use of the p-tolylsulfinyl group as a chiral inductor in stereoselective [4+3] cycloaddition reactions has made possible the preparation of enantiopure polysubstituted 8-oxabicyclo[3.2.1]oct-6-en-3-one systems having up to five stereocenters. The presence in the furan diene of a susbtituent at the 3-position bearing an atom with lone-pair electrons propitiates the coordination of a metallic atom by the sulfoxide and the R3 'ligand' group. This chelation effect, together with the stereoelectronic demand of the R3 and sulfoxide groups, considerably decreases the degree of conformational freedom of the diene moiety in the cyclic transition state leading to the observed stereoselectivity. By choosing appropriate substituents in the furan ring, it is possible to obtain 100:0 cis- trans and 100:0 endo- exo diastereoselectivities. Up to 100 % π-facial diastereoselectivity (enantioselectivity after removal of the sulfoxide group) could be reached. Yields lie within the range of 50-80 %, depending on the furan substrate. However, if the furan diene is fitted with deactivating electron-withdrawing substituents, low conversions were observed under certain reaction conditions, but always with excellent-to-complete chemo- and stereoselectivities. The conversion and yield increase on introduction of an electron-donating substituent at the C-3 of the furan ring. [ABSTRACT FROM AUTHOR]

Copyright of La Revista Latinoamericana de Metalurgia y Materiales, RLMM is the property of Universidad Simon Bolivar, Departmento de Ciencia de los Materiales and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This paper reports the synthesis, structural and magnetic characterization of the alloy CuAl0.67Cr0.33S2. The sample was synthesized using the technique of direct fusion of the constituent elements. Chemical analysis (EDX) allowed establishing the stoichiometric ratios for this alloy. The powder diffraction pattern was indexed and the main phase crystallizes with tetragonal symmetry and unit cell parameters a = 5.3410(1) Å, c = 10.4154(2) Å. This material is isomorphic with the chalcopyrite structure which crystallizes in space group I d 42 . Measurements of magnetic susceptibility and electronic paramagnetic resonance, depending on temperature, were performed in a SQUID magnetometer and a Bruker EMX X- band, respectively. The alloy exhibits a ferrimagnetic ordering with Néel temperature ~ 40 K. The EPR linewidth shows a paramagnetic behavior between 100 and 600 K, while the resonance field and the g factor show a slight variation with temperature. [ABSTRACT FROM AUTHOR]

Copyright of La Revista Latinoamericana de Metalurgia y Materiales, RLMM is the property of Universidad Simon Bolivar, Departmento de Ciencia de los Materiales and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Deals with an experimental design to optimize the welding process which is a component in manufacturing trains. Objectives of the experiment; List of variables considered potentially important for the experiment; Preparatory tasks before running the experiments.