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535 results on '"Gilbert, Debra J."'

2. Angiopoietins 3 and 4: Diverging Gene Counterparts in Mice and Humans

Author

Valenzuela, David M., Griffiths, Jennifer A., Rojas, Jose, Aldrich, Thomas H., Jones, Pamela F., Zhou, Hao, McClain, Joyce, Copeland, Neal G., Gilbert, Debra J., Jenkins, Nancy A., Huang, Tammy, Papadopoulos, Nick, Maisonpierre, Peter C., Davis, Samuel, and Yancopoulos, George D.

Published
1999

10. T Cell–Mediated Antitumor Immunity Cooperatively Induced By TGFβR1 Antagonism and Gemcitabine Counteracts Reformation of the Stromal Barrier in Pancreatic Cancer

Author

Li, Dandan, primary, Schaub, Nicholas, additional, Guerin, Theresa M., additional, Bapiro, Tashinga E., additional, Richards, Frances M., additional, Chen, Vicky, additional, Talsania, Keyur, additional, Kumar, Parimal, additional, Gilbert, Debra J., additional, Schlomer, Jerome J., additional, Kim, Seong-Jin, additional, Sorber, Rebecca, additional, Teper, Yaroslav, additional, Bautista, Wendy, additional, Palena, Claudia, additional, Ock, Chan-Young, additional, Jodrell, Duncan I., additional, Pate, Nathan, additional, Mehta, Monika, additional, Zhao, Yongmei, additional, Kozlov, Serguei, additional, and Rudloff, Udo, additional

Published
2021
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22. The thrombospondin-4 gene

Author

Newton, Gail, Weremowicz, Stanislawa, Morton, Cynthia C., Jenkins, Nancy A., Gilbert, Debra J., Copeland, Neal G., and Lawler, Jack

Published
1999
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24. Expression and chromosomal localization of the Requiem gene

Author

Gabig, Theodore G., Crean, Colin D., Klenk, Alison, Long, Haiyan, Copeland, Neal G., Gilbert, Debra J., Jenkins, Nancy A., Quincey, Danielle, Parente, Fabienne, Lespinasse, Françoise, Carle, Georges F., Gaudray, Patrick, Zhang, Chang X., Calender, Alain, Hoeppener, Jo, Kas, Koen, Thakker, Rajesh V., Farnebo, Filip, Teh, Bin T., Larsson, Catharina, Piehl, Fredrik, Lagercrantz, Jacob, Khodaei, Shideh, Carson, Emma, and Weber, Günther

Published
1998
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30. Comparative mapping of the human 22q11 chromosomal region and the orthologous region in mice reveals complex changes in gene organization

Author

Puech, Anne, Saint-Jore, Bruno, Funke, Birgit, Gilbert, Debra J., Sirotkin, Howard, Copeland, Neal G., Jenkins, Nancy A., Kucherlapati, Raju, Morrow, Bernice, and Skoultchi, Arthur I.

Subjects
Chromosome mapping -- Research, Human chromosomes -- Research, Mice -- Genetic aspects, Science and technology
Abstract

The region of human chromosome 22q11 is prone to rearrangements. The resulting chromosomal abnormalities are involved in Velo-cardio-facial and DiGeorge syndromes (VCFS and DGS) (deletions), 'cat eye' syndrome (duplications), and certain types of tumors (translocations). As a prelude to the development of mouse models for VCFS/DGS by generating targeted deletions in the mouse genome, we examined the organization of genes from human chromosome 22q11 in the mouse. Using genetic linkage analysis and detailed physical mapping, we show that genes from a relatively small region of human 22q11 are distributed on three mouse chromosomes (MMU6, MMU10, and MMU16). Furthermore, although the region corresponding to about 2.5 megabases of the VCFS/DGS critical region is located on mouse chromosome 16, the relative organization of the region is quite different from that in humans. Our results show that the instability of the 22q11 region is not restricted to humans but may have been present throughout evolution. The results also underscore the importance of detailed comparative mapping of genes in mice and humans as a prerequisite for the development of mouse models of human diseases involving chromosomal rearrangements.

Published
1997

31. The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha 1-5, identification of heterotrimeric laminis 8-11, and cloning of a novel alpha 3 isoform

Author

Miner, Jeffrey H., Patton, Bruce L., Lentz, Stephen I., Gilbert, Debra J., Snider, William D., Jenkins, Nancy A., Copeland, Neal G., and Sanes, Joshua R.

Subjects
Laminin -- Research, Membrane proteins -- Genetic aspects, Biological sciences
Abstract

The alpha chains of laminin trimers were studied. Alpha 1, 2, 3b, and 5 are full-sized chains while alpha 3A and 4 are truncated chains. All of the five alpha chains of laminin are expressed in both embryos and adults and form heterotrimers with beta and gamma chains. Alpha 5 was noted to be the most widely distributed chain in adult basal lamina, while alpha 1 was the most restricted. The main pattern of expression of the five chains are established embryonically, but individual basal laminae such as those of the kidney were noted to change in composition as they mature.

Published
1997

32. A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein

Author

Wang, Xin, Bornslaeger, Elayne A., Haub, Olivia, Tomihara-Newberger, Carol, Lonberg, Nils, Dinulos, Mary Beth, Disteche, Christine M., Copeland, Neal, Gilbert, Debra J., Jenkins, Nancy A., and Lacy, Elisabeth

Subjects
Gastrulation -- Genetic aspects, Mice -- Genetic aspects, Animal mutation -- Genetic aspects, Tumor necrosis factor -- Genetic aspects, Amnion -- Genetic aspects, Genetic transcription -- Research, Biological sciences
Abstract

We report the identification of a new recessive prenatal lethal insertional mutation, amnionless (amn). amn mutant embryos first appear abnormal during the Early Streak stage, between E6.5 and E7.0, when they initiate mesoderm production. Subsequently, the amn mutants become developmentally arrested between the Mid and Late Streak stages of gastrulation and they die and are resorbed between E9.5 and E10.5. While extraembryonic structures, including the chorion, yolk sac blood islands, and allantois appear to develop normally, the small embryonic ectoderm remains undifferentiated and generates no amnion. In addition, the embryonic mesoderm that is produced does not become organized into node, notochord, and somites and there is no morphological evidence of neural induction. Interspecific backcross and fluorescence in situ hybridization analyses map the transgene insertion, and thus the amn mutation, to the distal region of mouse chromosome 12, which has synteny with human chromosome 14q32. A gene encoding a 7.5-kb transcript has been identified at a junction between the integrated transgene and host chromosome 12 sequences that meets three criteria expected of a candidate amn gene. This gene maps to the site of transgene insertion; it is transcribed during gastrulation, and its expression is disrupted in amn mutant embryos. Nucleotide sequencing studies show that the 567 amino acid protein encoded by the 7.5-kb transcript is a member of the newly defined family of putative signal transducing proteins, TRAFs, that associate with the cytoplasmic domains of members of the tumor necrosis factor (TNF) receptor superfamily. Thus, we have named the gene encoding the 7.5-kb transcript TRAFamn. TRAFamn is identical to a recently reported protein (CD40bp, CAP-1, CRAF1, LAP1) that can bind the cytoplasmic domains of CD40 and the lymphotoxin [Beta] receptor (LT[Beta]R), both of which are known members of the TNF receptor superfamily. The implications of these findings regarding a possible role for the TNF receptor superfamily during gastrulation are discussed.

Published
1996

34. Mouse alpha N-catenin: two isoforms, specific expression in the nervous system, and chromosomal localization of the gene

Author

Uchida, Naoshiga, Shimamura, Kenji, Miyatani, Seiji, Copeland, Neal G., Gilbert, Debra J., Jenkins, Nancy A., and Takeichi, Masatoshi

Subjects
Circular DNA -- Genetic aspects, Gene expression -- Analysis, Nervous system -- Physiological aspects, Biological sciences
Abstract

Alpha N-catenin, a protein related with N-catenin in chicken, has two isoforms, alpha N-catenin I which is almost similar to chicken alpha N-catenin and alpha N-catenin II which is not identical as its C-terminal domain contains a 48-amino acid insertion. Alpha N-catenin is expressed only in the nervous system as revealed by in situ hybridization studies and immunostaining. Neural cell-cell interactions are also influenced by alpha N-catenin which is localized to chromosome 6.

Published
1994

37. A genetic linkage map of the mouse: current applications and future prospects

Author

Copeland, Neal G., Jenkins, Nancy A., Gilbert, Debra J., Eppig, Janan T., Maltais, Lois J., Miller, Joyce C., Dietrich, William F., Weaver, Alix, Lincoln, Stephen E., Steen, Robert G., Stein, Lincoln D., Nadeau, Joseph, and Lander, Eric S.

Subjects
Human genome -- Research, Chromosome mapping -- Research -- Genetic aspects, Mice -- Genetic aspects -- Research, Science and technology, Human genome -- Research
Abstract

Technological advances have made possible the development of high-resolution genetic linkage maps for the mouse. These maps in turn offer exciting prospects for understanding mammalian genome evolution through comparative mapping, for developing mouse models of human disease, and for identifying the function of all genes in the organism., Historically, the mouse has been the mammal of choice for genetic analysis primarily because of its short gestation period and large litter sizes, the availability of inbred strains, and the [...]

Published
1993

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