Search

Your search keyword '"Feldman, A L"' showing total 5,782 results
Start Over Author "Feldman, A L"
5,782 results on '"Feldman, A L"'

1. Water-COLOR: Water-COnservation using a Learning-based Optimized Recommender

Author

Zhang, GuangXue, Feldman, David L, Lin, Yiming, Mehrotra, Sharad, Venkatasubramanian, Nalini, Drew, Thayer, Sentovich, Kim, and Veranth, Owen

Subjects
Information and Computing Sciences, Human-Centred Computing
Abstract

Efficient water use, particularly in the realm of irrigation, has emerged as a critical concern in regions suffering from persistent drought, such as California and Florida. With the advent of smart irrigation controllers encouraged by environmental policies, a new paradigm of water management is gaining traction. Among these, the Rachio smart controller has garnered significant attention. However, without direct feedback or actual water usage data, optimizing these irrigation systems for enhanced efficiency remains challenging. This paper introduces Water-COLOR, a novel recommendation system integrated within the Rachio smart controller's framework to address this challenge. The system leverages similar landscape profiles to suggest irrigation schedules that are both water-efficient and user-preferable. By analyzing manual user interactions with the controller, Water-COLOR infers user satisfaction, which, along with estimated water usage, informs the adaptation of irrigation plans. The system eschews the need for additional sensors, thereby reducing infrastructure requirements. Our evaluation demonstrates consistent performance across diverse climatic regions and indicates that the system's recommendations could significantly contribute to water conservation efforts. The results not only showcase the potential of Water-COLOR to enhance the efficiency of existing smart irrigation systems but also open avenues for deploying real-time, data-driven environmental solutions.

Published
2024

6. State-level regulation of disinfection byproducts in the United States

Author

Wang, Jie, McNally, Max G, Ulibarri, Nicola, Gim, Changdeok, Olson, Valerie A, and Feldman, David L

Subjects
Policy and Administration, Human Society, Prevention, Generic health relevance, Clean Water and Sanitation, Disinfection byproducts, Policy analysis, Policy instruments, Water quality regulation, Applied Economics, Environmental Engineering, Applied economics, Policy and administration
Abstract

ABSTRACT: Disinfection byproducts (DBPs), residual compounds formed from the chemical disinfection of drinking water, can cause a host of damaging public health and environmental impacts. This study evaluates the landscape of regulations designed to reduce the occurrence and/or impact of DBPs, focusing on regulations issued by the US states. Drawing on a systematic search of state administrative codes and agency websites, we first identify the presence, absence, and layering of DBP-related regulations. We then evaluate the number and types of policy tools – the specific approaches required by each regulation, such as monitoring requirements, economic incentives, and required treatment technologies – to identify how DBPs are being managed and how states cluster with relatively more and less robust regulatory frameworks. Finally, we evaluate the relationship between the regulatory approach and the frequency of drinking water quality violations for DBP compounds. While most states have at least one DBP-specific regulation, these vary substantially in their comprehensiveness. The most-used policy tools (monitoring, compliance schedules, and reporting) directly reflect federal regulations; few states have adopted innovative tools such as collaboration or financial incentives. We observe no relationship between regulatory efforts and water quality violations, suggesting that current policy implementation may not adequately address the complex risk of DBPs.

Published
2024

7. Multiomic analysis identifies a high-risk signature that predicts early clinical failure in DLBCL

Author

Wenzl, Kerstin, Stokes, Matthew E., Novak, Joseph P., Bock, Allison M., Khan, Sana, Hopper, Melissa A., Krull, Jordan E., Dropik, Abigail R., Walker, Janek S., Sarangi, Vivekananda, Mwangi, Raphael, Ortiz, Maria, Stong, Nicholas, Huang, C. Chris, Maurer, Matthew J., Rimsza, Lisa, Link, Brian K., Slager, Susan L., Asmann, Yan, Mondello, Patrizia, Morin, Ryan, Ansell, Stephen M., Habermann, Thomas M., Witzig, Thomas E., Feldman, Andrew L., King, Rebecca L., Nowakowski, Grzegorz, Cerhan, James R., Gandhi, Anita K., and Novak, Anne J.

Published
2024
Full Text
View/download PDF

10. Cryo-EM structure of the human Sirtuin 6–nucleosome complex

Author

Chio, Un Seng, Rechiche, Othman, Bryll, Alysia R, Zhu, Jiang, Leith, Erik M, Feldman, Jessica L, Peterson, Craig L, Tan, Song, and Armache, Jean-Paul

Subjects
Biochemistry and Cell Biology, Physical Sciences, Biological Sciences, Genetics, 2.1 Biological and endogenous factors, Aetiology, Generic health relevance, Humans, Nucleosomes, Histones, Cryoelectron Microscopy, Chromatin, Sirtuins
Abstract

Sirtuin 6 (SIRT6) is a multifaceted protein deacetylase/deacylase and a major target for small-molecule modulators of longevity and cancer. In the context of chromatin, SIRT6 removes acetyl groups from histone H3 in nucleosomes, but the molecular basis for its nucleosomal substrate preference is unknown. Our cryo-electron microscopy structure of human SIRT6 in complex with the nucleosome shows that the catalytic domain of SIRT6 pries DNA from the nucleosomal entry-exit site and exposes the histone H3 N-terminal helix, while the SIRT6 zinc-binding domain binds to the histone acidic patch using an arginine anchor. In addition, SIRT6 forms an inhibitory interaction with the C-terminal tail of histone H2A. The structure provides insights into how SIRT6 can deacetylate both H3 K9 and H3 K56.

Published
2023

11. Transformation in marginal zone lymphoma: results from a prospective cohort and a meta-analysis of the literature

Author

Bommier, Côme, Link, Brian K., Gysbers, Brianna J., Maurer, Matthew J., Larson, Melissa C., Khurana, Arushi, Wang, Yucai, Thompson, Carrie A., Chihara, Dai, Alderuccio, Juan P., Koff, Jean L., Epperla, Narendranath, Conconi, Annarita, Lossos, Izidore S., Nowakowski, Grzegorz S., Feldman, Andrew L., Habermann, Thomas M., King, Rebecca L., and Cerhan, James R.

Published
2024
Full Text
View/download PDF

12. Advancing Genetic Testing in Kidney Diseases: Report From a National Kidney Foundation Working Group

Author

Ars, Elisabet, Reza Bekheirnia, Mir, Bier, Louise, Bleyer, Anthony J., Sr., Fuller, Lindsey J., Halbritter, Jan, Harris, Peter C., Kiryluk, Krzysztof, Knoers, Nine V.A.M., Kopp, Jeffrey B., Kramer, Holly, Lagas, Sharon S., Lieske, John C., Lu, Weining, Mannon, Roslyn B., Markowitz, Glen, Moe, Orson W., Nadkarni, Girish N., Nast, Cynthia C., Parekh, Rulan S., Pei, York, Reed, Katie, Rehm, Heidi L., Richards, Denay J., Roberts, Mary-Beth, Sabatello, Maya, Salant, David J., Sampson, Matthew G., Sanna-Cherchi, Simone, Santoriello, Dominick, Sedor, John R., Sneddon, Tam P., Watnick, Terry, Wilfond, Benjamin S., Williams, Winfred W., Wong, Craig S., Franceschini, Nora, Feldman, David L., Berg, Jonathan S., Besse, Whitney, Chang, Alexander R., Dahl, Neera K., Gbadegesin, Rasheed, Pollak, Martin R., Rasouly, Hila Milo, Smith, Richard J.H., Winkler, Cheryl A., and Gharavi, Ali G.

Published
2024
Full Text
View/download PDF

18. Breathing Rhythm and Pattern and Their Influence on Emotion

Author

Ashhad, Sufyan, Kam, Kaiwen, Del Negro, Christopher A, and Feldman, Jack L

Subjects
Medical Physiology, Biomedical and Clinical Sciences, Neurosciences, Behavioral and Social Science, Lung, Underpinning research, 1.1 Normal biological development and functioning, Neurological, Animals, Brain, Emotions, Mammals, Respiration, Respiratory Center, motor systems, central pattern generators, preBotzinger complex, synchrony, network dynamics, emotion, preBötzinger complex, Psychology, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

Breathing is a vital rhythmic motor behavior with a surprisingly broad influence on the brain and body. The apparent simplicity of breathing belies a complex neural control system, the breathing central pattern generator (bCPG), that exhibits diverse operational modes to regulate gas exchange and coordinate breathing with an array of behaviors. In this review, we focus on selected advances in our understanding of the bCPG. At the core of the bCPG is the preBötzinger complex (preBötC), which drives inspiratory rhythm via an unexpectedly sophisticated emergent mechanism. Synchronization dynamics underlying preBötC rhythmogenesis imbue the system with robustness and lability. These dynamics are modulated by inputs from throughout the brain and generate rhythmic, patterned activity that is widely distributed. The connectivity and an emerging literature support a link between breathing, emotion, and cognition that is becoming experimentally tractable. These advances bring great potential for elucidating function and dysfunction in breathing and other mammalian neural circuits.

Published
2022

20. DEVELOPING THERAPIES FOR C3G: REPORT OF THE KIDNEY HEALTH INITIATIVE C3G TRIAL ENDPOINTS WORK GROUP

Author

Nester, Carla, Decker, Dima A., Meier, Matthias, Aslam, Shakil, Bomback, Andrew S., Caravaca-Fontán, Fernando, Cook, Terence H., Feldman, David L., Fremeaux-Bacchi, Veronique, Gale, Daniel P., Gooch, Ann, Johnson, Sally, Licht, Christoph, Mathur, Mohit, Pickering, Matthew C., Praga, Manuel, Remuzzi, Giuseppe, Selvarajah, Viknesh, Smith, Richard J., Tabriziani, Hossein, van de Kar, Nicole, Wang, Yaqin, Wong, Edwin, Mistry, Kirtida, Lim, Mark, Portillo, Cesia, Balogun, Seyi, Trachtman, Howard, and Thompson, Aliza

Published
2024
Full Text
View/download PDF

22. Motive and opportunity: MYC rearrangements in high-grade B-cell lymphoma with MYC and BCL2 rearrangements (an LLMPP study)

Author

Hilton, Laura K., Collinge, Brett, Ben-Neriah, Susana, Alduaij, Waleed, Shaalan, Haya, Weng, Andrew P., Cruz, Manuela, Slack, Graham W., Farinha, Pedro, Miyata-Takata, Tomoko, Boyle, Merrill, Meissner, Barbara, Cook, James R., Ondrejka, Sarah L., Ott, German, Rosenwald, Andreas, Campo, Elias, Amador, Catalina, Greiner, Timothy C., Raess, Philipp W., Song, Joo Y., Inghirami, Giorgio, Jaffe, Elaine S., Weisenburger, Dennis D., Chan, Wing C., Beiske, Klaus, Fu, Kai, Delabie, Jan, Pittaluga, Stefania, Iqbal, Javeed, Wright, George, Sehn, Laurie H., Savage, Kerry J., Mungall, Andrew J., Feldman, Andrew L., Staudt, Louis M., Steidl, Christian, Rimsza, Lisa M., Morin, Ryan D., and Scott, David W.

Published
2024
Full Text
View/download PDF

25. Marginal zone lymphoma international prognostic index: a unifying prognostic index for marginal zone lymphomas requiring systemic treatment

Author

Arcaini, Luca, Bommier, Côme, Alderuccio, Juan Pablo, Merli, Michele, Fabbri, Nicole, Nizzoli, Maria Elena, Maurer, Matthew J., Tarantino, Vittoria, Ferrero, Simone, Rattotti, Sara, Talami, Annalisa, Murru, Roberta, Khurana, Arushi, Mwangi, Raphael, Deodato, Marina, Cencini, Emanuele, Re, Francesca, Visco, Carlo, Feldman, Andrew L., Link, Brian K., Delamain, Marcia Torresan, Spina, Michele, Annibali, Ombretta, Pulsoni, Alessandro, Ferreri, Andrés J.M., Stelitano, Caterina Cecilia, Pennese, Elsa, Habermann, Thomas M., Marcheselli, Luigi, Han, Sunwoo, Reis, Isildinha M., Paulli, Marco, Lossos, Izidore S., Cerhan, James R., and Luminari, Stefano

Published
2024
Full Text
View/download PDF

26. Indirect effects of the COVID-19 pandemic on diagnosing, monitoring, and prescribing in people with diabetes and strategies for diabetes service recovery internationally

Author

Rutter, Martin K., Carr, Matthew J., Wright, Alison K., Kanumilli, Naresh, Milne, Nicola, Jones, Ewan, Elton, Peter, Ceriello, Antonio, Misra, Anoop, Del Prato, Stefano, Barron, Emma, Hambling, Clare, Sattar, Naveed, Khunti, Kamlesh, Valabhji, Jonathan, Feldman, Eva L., and Ashcroft, Darren M.

Published
2024
Full Text
View/download PDF

27. Lymphomatoid Papulosis With T-cell Receptor–Gamma Delta Expression: A Clinicopathologic Case-series of 26 Patients of an Underrecognized Immunophenotypic Variant of Lymphomatoid Papulosis

Author

Mark, Erica, Kempf, Werner, Guitart, Joan, Pulitzer, Melissa, Mitteldorf, Christina, Hristov, Alexandra, Torres-Cabala, Carlos, Marchi, Enrica, Cropley, Thomas, Rodriguez Pinilla, Socorro Maria, Griffin, Teresa, Fernandez, Rony, Pileri, Stefano, Pileri, Alessandro, Tabanelli, Valentina, Borretta, Lisa, Subtil, Antonio, Plaza, Jose Antonio, Piris, Jose A. Miguel Angel, Feldman, Andrew L., Cerroni, Lorenzo, and Gru, Alejandro A.

Published
2024
Full Text
View/download PDF

29. Breast Implant Associated Anaplastic Large Cell Lymphoma: Evidence-Based Consensus Conference Statement From The American Association of Plastic Surgeons

Author

Clemens, Mark W., Myckatyn, Terence, Di Napoli, Arianna, Feldman, Andrew L., Jaffe, Elaine S., Haymaker, Cara L., Horwitz, Steven M., Hunt, Kelly K., Kadin, Marshall E., McCarthy, Colleen M., Miranda, Roberto N., Prince, H. Miles, Santanelli di Pompeo, Fabio, Holmes, Sari D., and Phillips, Linda G.

Published
2024
Full Text
View/download PDF

31. Health and health care access in the US transgender population health (TransPop) survey

Author

Feldman, Jamie L, Luhur, Winston Ekaprasetia, Herman, Jody L, Poteat, Tonia, and Meyer, Ilan H

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Clinical Sciences, Behavioral and Social Science, Sexual and Gender Minorities (SGM/LGBT*), Basic Behavioral and Social Science, Health Services, Clinical Research, Mental Health, Generic health relevance, Good Health and Well Being, Adult, Behavioral Risk Factor Surveillance System, Female, Health Services Accessibility, Health Services for Transgender Persons, Humans, Logistic Models, Male, Population Health, Transgender Persons, Transsexualism, United States, access to care, health, nonbinary, probability sample, transgender, Genetics, Paediatrics and Reproductive Medicine, Clinical sciences, Reproductive medicine
Abstract

BackgroundProbability and nonprobability-based studies of US transgender persons identify different disparities in health and health care access.ObjectivesWe used TransPop, the first US national probability survey of transgender persons, to describe and compare measures of health and health access among transgender, nonbinary, and cisgender participants. We directly compared the results with 2015 US Transgender Survey (USTS) data and with previously published analyses from the Behavioral Risk Factor Surveillance System (BRFSS).MethodsAll participants were screened by Gallup Inc., which recruited a probability sample of US adults. Transgender people were identified using a two-step screening process. Eligible participants completed self-administered questionnaires (transgender n = 274, cisgender n = 1162). We obtained weighted proportions/means, then tested for differences between gender groups. Logistic regression was performed to evaluate associations. Bivariate analyses were conducted using the weighted USTS data set for shared variables in USTS and TransPop.ResultsTransgender participants were younger and more racially diverse compared to the cisgender group. Despite equally high insurance coverage, transgender people more often avoided care due to cost concerns. Nonbinary persons were less likely to access transgender-related health care providers/clinics than transgender men and women. Transgender respondents more often rated their health as fair/poor, with more frequently occuring poor physical and mental health days compared to cisgender participants. Health conditions including HIV, emphysema, and ulcer were higher among transgender people. TransPop and USTS, unlike BRFSS-based analyses, showed no differences in health or health access.DiscussionTransgender persons experience health access disparities centered on avoidance of care due to cost beyond insured status. Health disparities correspond with models of minority stress, with nonbinary persons having distinct health/health access patterns. Despite different sampling methods, USTS and TransPop appear more similar than BRFSS studies regarding health/health access.ConclusionFuture research should elucidate health care costs for transgender and nonbinary people, while addressing methodology in national studies of transgender health.

Published
2021

33. Refining Diagnostic Subtypes of Peripheral T-Cell Lymphoma Using a Multiparameter Approach

Author

Amador, Catalina, Weisenburger, Dennis D., Gomez, Ana, Bouska, Alyssa, Alshomrani, Ahmad, Sharma, Sunandini, Shah, Rauf, Greiner, Timothy C., Vega, Francisco, Rosenwald, Andreas, Ott, German, Feldman, Andrew L., Jaffe, Elaine S., Ozkaya, Neval, Ondrejka, Sarah L., Cook, James R., Raess, Philipp W., Savage, Kerry J., Slack, Graham W., Song, Joo Y., Scott, David W., Campo, Elias, Rimsza, Lisa M., Khoury, Joseph D., Staudt, Louis M., Chan, Wing C., and Iqbal, Javeed

Published
2024
Full Text
View/download PDF

36. Microcircuit synchronization and heavy tailed synaptic weight distribution in preB\'otzinger Complex contribute to generation of breathing rhythm

Author

Slepukhin, Valentin M., Ashhad, Sufyan, Feldman, Jack L., and Levine, Alex J.

Subjects
Quantitative Biology - Neurons and Cognition, Condensed Matter - Disordered Systems and Neural Networks, Nonlinear Sciences - Adaptation and Self-Organizing Systems
Abstract

The preB\"otzinger Complex, the mammalian inspiratory rhythm generator, encodes inspiratory time as motor pattern. Spike synchronization throughout this sparsely connected network generates inspiratory bursts albeit with variable latencies after preinspiratory activity onset in each breathing cycle. Using preB\"otC rhythmogenic microcircuit minimal models, we examined the variability in probability and latency to burst, mimicking experiments. Among various physiologically plausible graphs of 1000 point neurons with experimentally determined neuronal and synaptic parameters, directed Erd\H{o}s-R\'enyi graphs best captured the experimentally observed dynamics. Mechanistically, preB\"otC (de)synchronization and oscillatory dynamics are regulated by the efferent connectivity of spiking neurons that gates the amplification of modest preinspiratory activity through input convergence. Furthermore, to replicate experiments, a lognormal distribution of synaptic weights was necessary to augment the efficacy of convergent coincident inputs. These mechanisms enable exceptionally robust yet flexible preB\"otC attractor dynamics that, we postulate, represent universal temporal-processing and decision-making computational motifs throughout the brain., Comment: 47 pages, 10 figures

Published
2020

37. Variable selection with multiply-imputed datasets: choosing between stacked and grouped methods

Author

Du, Jiacong, Boss, Jonathan, Han, Peisong, Beesley, Lauren J, Goutman, Stephen A, Batterman, Stuart, Feldman, Eva L, and Mukherjee, Bhramar

Subjects
Statistics - Methodology, Statistics - Applications, Statistics - Computation
Abstract

Penalized regression methods, such as lasso and elastic net, are used in many biomedical applications when simultaneous regression coefficient estimation and variable selection is desired. However, missing data complicates the implementation of these methods, particularly when missingness is handled using multiple imputation. Applying a variable selection algorithm on each imputed dataset will likely lead to different sets of selected predictors, making it difficult to ascertain a final active set without resorting to ad hoc combination rules. In this paper we consider a general class of penalized objective functions which, by construction, force selection of the same variables across multiply-imputed datasets. By pooling objective functions across imputations, optimization is then performed jointly over all imputed datasets rather than separately for each dataset. We consider two objective function formulations that exist in the literature, which we will refer to as "stacked" and "grouped" objective functions. Building on existing work, we (a) derive and implement efficient cyclic coordinate descent and majorization-minimization optimization algorithms for both continuous and binary outcome data, (b) incorporate adaptive shrinkage penalties, (c) compare these methods through simulation, and (d) develop an R package miselect for easy implementation. Simulations demonstrate that the "stacked" objective function approaches tend to be more computationally efficient and have better estimation and selection properties. We apply these methods to data from the University of Michigan ALS Patients Repository (UMAPR) which aims to identify the association between persistent organic pollutants and ALS risk., Comment: 23 pages, 6 figures. This paper has been submitted to Statistics in Medicine

Published
2020

41. Environmental Attitudes and Knowledge: Do They Matter for Support and Investment in Local Stormwater Infrastructure?

Author

Pierce, Gregory, Gmoser-Daskalakis, Kyra, Rippy, Megan A, Holden, Patricia A, Grant, Stanley B, Feldman, David L, and Ambrose, Richard F

Subjects
Economics, Applied Economics, Industry, Innovation and Infrastructure, Campus sustainability, environmental knowledge, green infrastructure, New Ecological Paradigm (NEP) scale, stormwater management, willingness to pay and public support, Ecology
Abstract

Stormwater infrastructure substantially impacts water quality and supply. In the U.S., local agency investments rely on public support from taxes or fees. Assessing individuals’ knowledge and willingness to pay helps inform potential pathways to funding and green infrastructure implementation. Using a 2018–2019 survey of 868 University of California students and staff, we analyze stormwater knowledge and willingness to pay or support public fund allocation for green infrastructure, especially natural treatment systems (NTS). Results of three separate regression models, each with a one-campus random sample and an all-campus convenience sample, show the majority of respondents supported allocating personal and campus funds for NTS. Preexisting environmental attitudes (on the New Ecological Paradigm scale) were the most common driver in nearly all models, but with inconsistent results and low explanatory power across models. Harnessing public support to increase stormwater investment may require tailored benefit messaging or other motivational frameworks, particularly in semiarid environments.

Published
2021

45. Research Priorities for Patients with Heart Failure and Central Sleep Apnea. An Official American Thoracic Society Research Statement

Author

Orr, Jeremy E, Ayappa, Indu, Eckert, Danny J, Feldman, Jack L, Jackson, Chandra L, Javaheri, Shahrokh, Khayat, Rami N, Martin, Jennifer L, Mehra, Reena, Naughton, Matthew T, Randerath, Winfried J, Sands, Scott A, Somers, Virend K, and Badr, M Safwan

Subjects
Sleep Research, Lung, Clinical Research, Cardiovascular, Good Health and Well Being, Adult, Aged, Aged, 80 and over, Biomedical Research, Female, Forecasting, Heart Failure, Humans, Male, Middle Aged, Research Design, Sleep Apnea, Central, Societies, Medical, United States, sleep apnea, heart failure, respiration, Medical and Health Sciences, Respiratory System
Abstract

Background: Central sleep apnea (CSA) is common among patients with heart failure and has been strongly linked to adverse outcomes. However, progress toward improving outcomes for such patients has been limited. The purpose of this official statement from the American Thoracic Society is to identify key areas to prioritize for future research regarding CSA in heart failure.Methods: An international multidisciplinary group with expertise in sleep medicine, pulmonary medicine, heart failure, clinical research, and health outcomes was convened. The group met at the American Thoracic Society 2019 International Conference to determine research priority areas. A statement summarizing the findings of the group was subsequently authored using input from all members.Results: The workgroup identified 11 specific research priorities in several key areas: 1) control of breathing and pathophysiology leading to CSA, 2) variability across individuals and over time, 3) techniques to examine CSA pathogenesis and outcomes, 4) impact of device and pharmacological treatment, and 5) implementing CSA treatment for all individualsConclusions: Advancing care for patients with CSA in the context of heart failure will require progress in the arenas of translational (basic through clinical), epidemiological, and patient-centered outcome research. Given the increasing prevalence of heart failure and its associated substantial burden to individuals, society, and the healthcare system, targeted research to improve knowledge of CSA pathogenesis and treatment is a priority.

Published
2021

46. Silent hypoxaemia in COVID-19 patients.

Author

Simonson, Tatum S, Baker, Tracy L, Banzett, Robert B, Bishop, Tammie, Dempsey, Jerome A, Feldman, Jack L, Guyenet, Patrice G, Hodson, Emma J, Mitchell, Gordon S, Moya, Esteban A, Nokes, Brandon T, Orr, Jeremy E, Owens, Robert L, Poulin, Marc, Rawling, Jean M, Schmickl, Christopher N, Watters, Jyoti J, Younes, Magdy, and Malhotra, Atul

Subjects
Humans, Dyspnea, Hypoxia, COVID-19, SARS-CoV-2, dyspnoea, happy hypoxia, silent hypoxaemia, Biological Sciences, Medical and Health Sciences, Physiology
Abstract

The clinical presentation of COVID-19 due to infection with SARS-CoV-2 is highly variable with the majority of patients having mild symptoms while others develop severe respiratory failure. The reason for this variability is unclear but is in critical need of investigation. Some COVID-19 patients have been labelled with 'happy hypoxia', in which patient complaints of dyspnoea and observable signs of respiratory distress are reported to be absent. Based on ongoing debate, we highlight key respiratory and neurological components that could underlie variation in the presentation of silent hypoxaemia and define priorities for subsequent investigation.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results