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13. Association of gallstone and polymorphisms of UGT1A1*27 and UGT1A1*28 in patients with hepatitis B virus-related liver failure

Author

Zhuo Haiyan, Fan Jinhai, Zhang Bifeng, Shi Yixian, Zheng Liqing, Chai Yihong, and Yao Lvfeng

Subjects
ugt1a1, gallstone, liver failure, hepatitis b virus, single-nucleotide polymorphism, Medicine
Abstract

Genetic variation in UDP-glucuronosyltransferase 1A1 gene (UGT1A1) is a lithogenic risk factor for gallstone formation. This study aimed to assess genotype and allele frequencies of common UGT1A1 variants in patients with gallstone and hepatitis B virus (HBV)-related hepatic failure. This study enrolled 113 healthy individuals (CTRL), 54 patients with HBV infection (HBV), 134 patients with gallstone-free hepatic failure and HBV infection, and 34 patients with gallstone-related hepatic failure and HBV infection (GRHF). Peripheral venous blood samples were collected for genomic DNA isolation. Polymerase chain reaction amplification was carried out for UGT1A1, followed by direct sequencing. Analysis for genotype and allele frequencies of UGT1A1 variants (UGT1A1*6, UGT1A1*27, UGT1A1*28, and UGT1A1*60) was performed. The allele distributions of the four groups did not deviate from Hardy–Weinberg equilibrium. Allele (A) and genotype (CA) frequency distributions of UGT1A1*27 were significantly different between GRHF and CTRL, or between GRHF and HBV. GRHF and CTRL exhibited significant differences in allele (A) and genotype (CA) frequency distributions of UGT1A1*28. Linkage disequilibrium analysis suggested that haplotype G-G-[TA]7-T may be associated with gallstone in HBV-related hepatic failure. Our data reveal that UGT1A1*27 and UGT1A1*28 variants are significantly observed in patients with GRHF compared to healthy individuals.

Published
2022
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20. Survival after radical cystectomy for bladder cancer: Multicenter comparison between minimally invasive and open approaches

Author

Xie, Weibin, Bi, Junming, Wei, Qiang, Han, Ping, Song, Dongkui, Shi, Lei, Ye, Dingwei, Shen, Yijun, Gou, Xin, He, Weiyang, Wang, Shaogang, Liu, Zheng, Fan, Jinhai, Wu, Kaijie, Chen, Zhiwen, Zhou, Xiaozhou, Kong, Chuize, Liu, Yang, Liu, Chunxiao, Xu, Abai, Jin, Baiye, Fu, Guanghou, Xue, Wei, Chen, Haige, Pan, Tiejun, Tu, Zhong, Lin, Tianxin, and Huang, Jian

Published
2020
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25. Table S1-S8 from Urinary Tumor DNA MRD Analysis to Identify Responders to Neoadjuvant Immunotherapy in Muscle-invasive Bladder Cancer

Author

Zhang, Ruiyun, primary, Zang, Jingyu, primary, Jin, Di, primary, Xie, Feng, primary, Shahatiaili, Akezhouli, primary, Wu, Guangyu, primary, Zhang, Lu, primary, Wang, Lu, primary, Zhang, Yue, primary, Zhao, Zhixin, primary, Du, Pan, primary, Jia, Shidong, primary, Fan, Jinhai, primary, Zhuang, Guanglei, primary, and Chen, Haige, primary

Published
2023
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26. Figure S1-S6 from Urinary Tumor DNA MRD Analysis to Identify Responders to Neoadjuvant Immunotherapy in Muscle-invasive Bladder Cancer

Author

Zhang, Ruiyun, primary, Zang, Jingyu, primary, Jin, Di, primary, Xie, Feng, primary, Shahatiaili, Akezhouli, primary, Wu, Guangyu, primary, Zhang, Lu, primary, Wang, Lu, primary, Zhang, Yue, primary, Zhao, Zhixin, primary, Du, Pan, primary, Jia, Shidong, primary, Fan, Jinhai, primary, Zhuang, Guanglei, primary, and Chen, Haige, primary

Published
2023
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27. Data from Urinary Tumor DNA MRD Analysis to Identify Responders to Neoadjuvant Immunotherapy in Muscle-invasive Bladder Cancer

Author

Zhang, Ruiyun, primary, Zang, Jingyu, primary, Jin, Di, primary, Xie, Feng, primary, Shahatiaili, Akezhouli, primary, Wu, Guangyu, primary, Zhang, Lu, primary, Wang, Lu, primary, Zhang, Yue, primary, Zhao, Zhixin, primary, Du, Pan, primary, Jia, Shidong, primary, Fan, Jinhai, primary, Zhuang, Guanglei, primary, and Chen, Haige, primary

Published
2023
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28. Supplementary Information 1 from Urinary Tumor DNA MRD Analysis to Identify Responders to Neoadjuvant Immunotherapy in Muscle-invasive Bladder Cancer

Author

Zhang, Ruiyun, primary, Zang, Jingyu, primary, Jin, Di, primary, Xie, Feng, primary, Shahatiaili, Akezhouli, primary, Wu, Guangyu, primary, Zhang, Lu, primary, Wang, Lu, primary, Zhang, Yue, primary, Zhao, Zhixin, primary, Du, Pan, primary, Jia, Shidong, primary, Fan, Jinhai, primary, Zhuang, Guanglei, primary, and Chen, Haige, primary

Published
2023
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31. Urinary Tumor DNA MRD Analysis to Identify Responders to Neoadjuvant Immunotherapy in Muscle-invasive Bladder Cancer

Author

Zhang, Ruiyun, primary, Zang, Jingyu, additional, Jin, Di, additional, Xie, Feng, additional, Shahatiaili, Akezhouli, additional, Wu, Guangyu, additional, Zhang, Lu, additional, Wang, Lu, additional, Zhang, Yue, additional, Zhao, Zhixin, additional, Du, Pan, additional, Jia, Shidong, additional, Fan, Jinhai, additional, Zhuang, Guanglei, additional, and Chen, Haige, additional

Published
2023
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37. MP63-18 UriFIND ASSAY FACILITATES WHOLE COURSE MANAGEMENT OF UROTHELIAL CARCINOMA IN A LARGE MULTICENTRIC, PROSPECTIVE CHINA COHORT

Author

Chen, XU, primary, Liu, Zheng, additional, Zhou, Liqun, additional, Fan, Jinhai, additional, Ruan, Weimei, additional, Wang, Hong, additional, Lv, Qiang, additional, Wei, Qiang, additional, Chen, Haige, additional, Xu, Tao, additional, Li, Lei, additional, Wang, Shaogang, additional, Tan, Wanglong, additional, Xu, Abai, additional, Yang, Jin, additional, Liao, Hong, additional, Zhong, Jianmei, additional, Li, Xia, additional, Chen, Zhiwei, additional, Bibikova, Marina, additional, Fan, Jianbing, additional, Huang, Jian, additional, and Lin, Tianxin, additional

Published
2023
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38. Supplemental Figure 3 from Safety, Efficacy, and Biomarker Analysis of Toripalimab in Patients with Previously Treated Advanced Urothelial Carcinoma: Results from a Multicenter Phase II Trial POLARIS-03

Author

Sheng, Xinan, primary, Chen, Haige, primary, Hu, Bin, primary, Yao, Xudong, primary, Liu, Ziling, primary, Yao, Xin, primary, Guo, Hongqian, primary, Hu, Yi, primary, Ji, Zhigang, primary, Luo, Hong, primary, Shi, Benkang, primary, Liu, Jiyan, primary, Wu, Jin, primary, Zhou, FangJian, primary, He, Zhisong, primary, Fan, Jinhai, primary, Wang, Weifeng, primary, Feng, Hui, primary, Yao, Sheng, primary, Keegan, Patricia, primary, Huang, Yiran, primary, and Guo, Jun, primary

Published
2023
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39. Supplemental Figure 1 from Safety, Efficacy, and Biomarker Analysis of Toripalimab in Patients with Previously Treated Advanced Urothelial Carcinoma: Results from a Multicenter Phase II Trial POLARIS-03

Author

Sheng, Xinan, primary, Chen, Haige, primary, Hu, Bin, primary, Yao, Xudong, primary, Liu, Ziling, primary, Yao, Xin, primary, Guo, Hongqian, primary, Hu, Yi, primary, Ji, Zhigang, primary, Luo, Hong, primary, Shi, Benkang, primary, Liu, Jiyan, primary, Wu, Jin, primary, Zhou, FangJian, primary, He, Zhisong, primary, Fan, Jinhai, primary, Wang, Weifeng, primary, Feng, Hui, primary, Yao, Sheng, primary, Keegan, Patricia, primary, Huang, Yiran, primary, and Guo, Jun, primary

Published
2023
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40. Supplemental Table 1-3 from Safety, Efficacy, and Biomarker Analysis of Toripalimab in Patients with Previously Treated Advanced Urothelial Carcinoma: Results from a Multicenter Phase II Trial POLARIS-03

Author

Sheng, Xinan, primary, Chen, Haige, primary, Hu, Bin, primary, Yao, Xudong, primary, Liu, Ziling, primary, Yao, Xin, primary, Guo, Hongqian, primary, Hu, Yi, primary, Ji, Zhigang, primary, Luo, Hong, primary, Shi, Benkang, primary, Liu, Jiyan, primary, Wu, Jin, primary, Zhou, FangJian, primary, He, Zhisong, primary, Fan, Jinhai, primary, Wang, Weifeng, primary, Feng, Hui, primary, Yao, Sheng, primary, Keegan, Patricia, primary, Huang, Yiran, primary, and Guo, Jun, primary

Published
2023
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42. Supplemental Figure 2 from Safety, Efficacy, and Biomarker Analysis of Toripalimab in Patients with Previously Treated Advanced Urothelial Carcinoma: Results from a Multicenter Phase II Trial POLARIS-03

Author

Sheng, Xinan, primary, Chen, Haige, primary, Hu, Bin, primary, Yao, Xudong, primary, Liu, Ziling, primary, Yao, Xin, primary, Guo, Hongqian, primary, Hu, Yi, primary, Ji, Zhigang, primary, Luo, Hong, primary, Shi, Benkang, primary, Liu, Jiyan, primary, Wu, Jin, primary, Zhou, FangJian, primary, He, Zhisong, primary, Fan, Jinhai, primary, Wang, Weifeng, primary, Feng, Hui, primary, Yao, Sheng, primary, Keegan, Patricia, primary, Huang, Yiran, primary, and Guo, Jun, primary

Published
2023
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44. Efficacy and safety of a novel 450 nm blue diode laser versus plasmakinetic electrocautery for the transurethral resection of non-muscle invasive bladder cancer: The protocol and result of a multicenter randomized controlled trial

Author

Wu, Kaijie, primary, Jiang, Dali, additional, Zhang, Lianhua, additional, Jiang, Shuai, additional, Lin, Tianhai, additional, Luo, Yi, additional, Fan, Jinhai, additional, Yang, Tao, additional, Chen, Haige, additional, Zhang, Peng, additional, Wang, Xinghuan, additional, Wei, Qiang, additional, Guo, Jianming, additional, Huang, Yiran, additional, and He, Dalin, additional

Published
2023
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48. Identification of a six-gene prognostic signature for bladder cancer associated macrophage

Author

Jiang, Yunzhong, Qu, Xiaowei, Zhang, Mengzhao, Zhang, Lu, Yang, Tao, Ma, Minghai, Jing, Minxuan, Zhang, Nan, Song, Rundong, Zhang, Yuanquan, Yang, Zezhong, Zhang, Yaodong, Pu, Yuanchun, and Fan, Jinhai

Subjects
Gene Expression Regulation, Neoplastic, Urinary Bladder Neoplasms, Gene Expression Profiling, Macrophages, Immunology, Biomarkers, Tumor, Tumor Microenvironment, Humans, Immunology and Allergy, Folate Receptor 2, Prognosis, Adaptor Proteins, Signal Transducing
Abstract

As major components of the tumor microenvironment (TME), tumor-associated macrophages (TAMs) play an exceedingly complicated role in tumor progression and tumorigenesis. However, few studies have reported the specific TAM gene signature in bladder cancer. Herein, this study focused on developing a TAM-related prognostic model in bladder cancer patients based on The Cancer Genome Atlas (TCGA) data. Weighted Gene Co-Expression Network Analysis (WGCNA) was used to identify key genes related to TAM (M2 macrophage). Gene ontology (GO) enrichment and the Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway analysis showed the functional categories of the key genes. Simultaneously, we used the Least Absolute Shrinkage and Selection Operator (LASSO) and univariate and multivariate Cox regressions to establish a TMA-related prognostic model containing six key genes: TBXAS1, GYPC, HPGDS, GAB3, ADORA3, and FOLR2. Subsequently, single-cell sequencing data downloaded from Gene Expression Omnibus (GEO) suggested that the six genes in the prognostic model were expressed in TAM specifically and may be involved in TAM polarization. In summary, our research uncovered six-TAM related genes that may have an effect on risk stratification in bladder cancer patients and could be regarded as potential TAM-related biomarkers.

Published
2022

49. Potential Mechanisms of Osthole against Bladder Cancer Based on Network Pharmacology, Molecular Docking, and Experimental Validation

Author

Jiang, Yunzhong, primary, Zhang, Mengzhao, additional, Wang, Lu, additional, Zhang, Lu, additional, Ma, Minghai, additional, Jing, Minxuan, additional, Li, Jianpeng, additional, Song, Rundong, additional, Zhang, Yuanquan, additional, Yang, Zezhong, additional, Zhang, Yaodong, additional, Pu, Yuanchun, additional, Qu, Xiaowei, additional, and Fan, Jinhai, additional

Published
2022
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50. Identification of Biomarkers Related to Tumor Associated Macrophages in Clear Cell Renal Cell Carcinoma with Weighted gene co-expression network analysis

Author

Jiang, Yunzhong, primary, Zhang, Mengzhao, additional, Zhang, Lu, additional, Wang, Lu, additional, Ma, Minghai, additional, Jing, Minxuan, additional, Li, Jianpeng, additional, Song, Rundong, additional, Zhang, Yuanquan, additional, Yang, Zezhong, additional, Zhang, Yaodong, additional, Pu, Yuanchun, additional, and Fan, Jinhai, additional

Published
2022
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