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2. Iconic CO2 time series at risk

Author

Houweling, S, Badawy, B, Baker, DF, Basu, S, Belikov, D, Bergamaschi, P, Bousquet, P, Broquet, G, Butler, T, Canadell, JG, Chen, J, Chevallier, F, Ciais, P, Collatz, JG, Denning, S, Engelen, R, Enting, IG, Fischer, ML, Fraser, A, Gerbig, C, Gloor, M, Jacobson, AR, Jones, DBA, Heimann, M, Khalil, A, Kaminski, T, Kasibhatla, PS, Krakauer, NY, Krol, M, Maki, T, Maksyutov, S, Manning, A, Meesters, A, Miller, JB, Palmer, PI, Patra, P, Peters, W, Peylin, P, Poussi, Z, Prather, MJ, Randerson, JT, Röckmann, T, Rödenbeck, C, Sarmiento, JL, Schimel, DS, Scholze, M, Schuh, A, Suntharalingam, P, Takahashi, T, Turnbull, J, Yurganov, L, and Vermeulen, A

Published
2012

7. Three participatory geographers: reflections on positionality and working with participants in researching religions, spiritualities, and faith.

Author

Denning, S., Scriven, R., and Slatter, R

Subjects
*GEOGRAPHERS, *PARTICIPANT observation, *HUMAN research subjects, *SPIRITUALITY, *FAITH
Abstract

This paper advances the geographies of religion, spirituality and faith's limited attention to positionality by discussing the critical issues raised when using participatory approaches. Reflecting on three cases of participatory research, we foreground the dynamics of being a researcher with faith when working with participants from faith communities. Advocating participatory approaches as valuable methodologies that should be used more extensively to explore beliefs, faith practices, and social justice, we argue that greater attention needs to be given to the positionality of researchers undertaking this sort of research. Our cases raise three themes for discussion. First, the variety of ways in which faith positionalities influence how research is developed, conducted and concluded. Second, the intersections between our faith and other positionalities and how they shape our roles and relationships with research participants. Third, the fluid and multifaceted nature of faith positionalities and how they are changed, emphasized, and softened through the dynamics and entanglements of fieldwork. In doing so, we reflect on the complexities of being a researcher with faith, argue that faith positionality is a helpful dimension of their research rather than a limitation, and that all cultural, social and historical geographical researchers should reflect on their faith positionality. [ABSTRACT FROM AUTHOR]

Published
2022
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8. Baseline characteristics of patients in the Reduction of Events with Darbepoetin alfa in Heart Failure trial (RED-HF)

Author

McMurray, John J.V., Anand, Inder S., Diaz, Rafael, Maggioni, Aldo P., OʼConnor, Christopher, Pfeffer, Marc A., Solomon, Scott D., Tendera, Michal, van Veldhuisen, Dirk J., Albizem, Moetaz, Cheng, Sunfa, Scarlata, Debra, Swedberg, Karl, Young, James B., Amuchastegui, M., Belziti, C., Bluguermann, J., Caccavo, M., Cartasegna, L., Colque, R., Cuneo, C., Fernandez, A., Gabito, A., Goicochea, R., Gonzalez, M., Gorosito, V., Grinfeld, L., Hominal, M., Kevorkian, R., Litvak Bruno, M., Llanos, J., Mackinnon, I., Manuale, O., Marzetti, E., Nul, D., Perna, E., Riccitelli, M., Sanchez, A., Santos, D., Schygiel, P., Toblli, J., Vogel, D., Aggarwal, A., Amerena, J., De Looze, F., Fletcher, P., Hare, D., Ireland, M., Krum, H., Lattimore, J., Marwick, T., Sindone, A., Thompson, P., Waites, J., Altenberger, J., Ebner, C., Lenz, K., Pacher, R., Poelzl, G., Charlier, F., de Ceuninck, M., De Keulenaer, G., Dendale, P., Maréchal, P., Mullens, W., Thoeng, J., Vanderheyden, M., Vanhaecke, J., Weytjens, C., Wollaert, B., Albuquerque, D., Almeida, D., Aspe y Rosas, J., Bocchi, E., Bordignon, S., Clausell, N., Kaiser, S., Leaes, P., Martins Alves, S., Montera, M., Moura, L., Pereira de Castro, R., Rassi, S., Reis, A., Saraiva, J., Simões, M., Souza Neto, J., Teixeira, M., Benov, H., Chompalova, B., Donova, T., Georgiev, P., Gotchev, D., Goudev, A., Grigorov, M., Guenova, D., Hergeldjieva, V., Ivanov, D., Kostova, E., Manolova, A., Marchev, S., Nikolov, F., Popov, A., Raev, D., Tzekova, M., Czarnecki, W., Giannetti, N., Haddad, H., Heath, J., Huynh, T., Lepage, S., Liu, P., Lonn, E., Ma, P., Manyari, D., Moe, G., Parker, J., Pesant, Y., Rajda, M., Ricci, J., Roth, S., Sestier, F., Sluzar, V., Sussex, B., Vizel, S., Antezana, G., Bugueno, C., Castro, P., Conejeros, C., Manriquez, L., Martinez, D., Potthoff, S., Stockins, B., Vukasovic, J., Gregor, P., Herold, M., Jerabek, O., Jirmar, R., Kuchar, R., Linhart, A., Podzemska, B., Soucek, M., Spac, J., Spacek, R., Vodnansky, P., Bronnum-Schou, J., Clemmensen, K., Egstrup, K., Jensen, G., Kjoller-Hansen, L., Kober, L., Markenvard, J., Rokkedal, J., Skagen, K., Torp-Pedersen, C., Tuxen, C., Videbak, L., Laks, T., Vahula, V., Harjola, V., Kettunen, R., Kotila, M., Bauer, F., Cohen Solal, A., Coisne, D., Davy, J., De Groote, P., Dos Santos, P., Funck, F., Galinier, M., Gibelin, P., Isnard, R., Neuder, Y., Roul, G., Sabatier, R., Trochu, J., Anker, S., Denny, S., Dreykluft, T., Flesch, M., Genth-Zotz, S., Hambrecht, R., Hein, J., Jeserich, M., John, M., Kreider-Stempfle, H., Laufs, U., Muellerleile, K., Natour, M., Sandri, M., Schäufele, T., von Hodenberg, E., Weyland, K., Winkelmann, B., Tse, H., Yan, B., Barsi, B., Csikasz, J., Dezsi, C., Edes, I., Forster, T., Karpati, P., Kerekes, C., Kis, E., Kosa, I., Lupkovics, G., Nagy, A., Preda, I., Ronaszeki, A., Tomcsanyi, J., Zamolyi, K., Agarwal, D., Bahl, V., Bordoloi, A., Chockalingam, K., Chopda, M., Chopra, V., Dugal, J., Ghaisas, N., Ghosh, S., Grant, P., Hiremath, S., Iyengar, S., Jagadeesa Subramania, B., Jain, P., Joshi, A., Khan, A., Mullasari, A., Naik, S., Oomman, A., Pai, V., Pareppally Gopal, R., Parikh, K., Patel, T., Prakash, V., Sastry, B., Sathe, S., Sinha, N., Srikanthan, V., Subburamakrishnan, P., Thacker, H., Wander, G., Admon, D., Katz, A., Klainman, E., Lewis, B., Marmor, A., Moriel, M., Mosseri, M., Shotan, A., Weinstein, J., Zimlichman, R., Agostoni, P., Albanese, M., Alunni, G., Bini, R., Boccanelli, A., Bolognese, L., Campana, C., Carbonieri, E., Carpino, C., Checco, L., Cosmi, F., DʼAngelo, G., De Cristofaro, M., Floresta, A., Fucili, A., Galvani, M., Ivleva, A., Marra, S., Musca, G., Peccerillo, N., Perrone Filardi, P., Picchio, E., Russo, T., Scelsi, L., Senni, M., Tavazzi, L., Erglis, A., Jasinkevica, I., Kakurina, N., Veze, I., Volans, E., Bagdonas, A., Berukstis, E., Celutkiene, J., Dambrauskaite, A., Jarasuniene, D., Luksiene, D., Rudys, A., Sakalyte, G., Sliaziene, S., Aguilar-Romero, R., Cardona-Muñoz, E., Castro-Jimenez, J., Chavez-Herrera, J., Chuquiure Valenzuela, E., De la Pena, G., Herrera, E., Leiva-Pons, J., Lopez Alvarado, A., Mendez Machado, G., Ramos-Lopez, G., Basart, D., Buijs, E., Cornel, J., de Leeuw, M., Dijkgraaf, R., Dunselman, P., Freericks, M., Hamraoui, K., Lenderlink, T., Linssen, G., Lodewick, P., Lodewijks, C., Lok, D., Nierop, P., Ronner, E., Somsen, A., van Dantzig, J., van der Burgh, P., van Kempen, L., van Vlies, B., Voors, A., Wardeh, A., Willems, F., Dickstein, K., Gundersen, T., Hole, T., Thalamus, J., Westheim, A., Dabrowski, M., Gorski, J., Korewicki, J., Kuc, K., Miekus, P., Musial, W., Niegowska, J., Piotrowski, W., Podolec, P., Polonski, L., Ponikowski, P., Rynkiewicz, A., Szelemej, R., Trusz-Gluza, M., Ujda, M., Wojciechowski, D, Wysokinski, A., Camacho, A., Fonseca, C., Monteiro, P., Apetrei, E., Bruckner, I., Carasca, E., Coman, I., Datcu, M., Dragulescu, S., Ionescu, P., Iordachescu-Petica, D., Manitiu, I., Popa, V., Pop-Moldovan, A., Radoi, M., Stamate, S., Tomescu, M., Vita, I., Aroutiounov, G., Ballyuzek, M., Bart, B., Churina, S., Glezer, M., Goloshchekin, B., Ivleva, A., Kobalava, Z., Kostenko, V., Lopatin, Y., Martynov, A., Orlov, V., Semernin, E., Shogenov, Z., Sidorenko, B., Skvortsov, A., Storzhakov, G., Sulimov, V., Talibov, O., Tereshenko, S., Tsyrline, V., Zadionchenko, V., Zateyshchikov, D., Dzupina, A., Hranai, M., Kmec, J., Micko, K., Murin, J., Pella, D., Sojka, G., Spisak, V., Vahala, P., Vinanska, D., Badat, A., Bayat, J., Dawood, S., Delport, E., Ellis, G., Garda, R., Klug, E., Mabin, T., Naidoo, D., Pretorius, M., Ranjith, N., Van Zyl, L., Weich, H., Anguita, M., Berrazueta, J., Bruguera i Cortada, J., de Teresa, E., Gómez Sánchez, M., González Juanatey, J., Gonzalez-Maqueda, I., Jordana, R., Lupon, J., Manzano, L., Pascual Figal, D., Pulpón, L., Recio, J., Ridocci Soriano, F., Rodríguez Lambert, J., Roig Minguell, E., Roig Minguell, E., Romero, J., Valdovinos, P., Klintberg, L., Kronvall, T., Lycksell, M., Morner, S., Rydberg, E., Swedberg, K., Timberg, I., Wikstrom, G., Moccetti, T.4, Ashok, J., Banerjee, P., Carr-White, G., Cleland, J., Connolly, E., Francis, M., Greenbaum, R., Kadr, H., Lindsay, S., McMurray, J., Megarry, S., Memon, A., Murdoch, D., Senior, R., Squire, I., Tan, L., Witte, K., Adams, K., Adamson, P., Adler, A., Altschul, L., Altschuller, A., Amirani, H., Anand, I., Andreou, C., Ansari, M., Antonishen, M., Banchs, H., Banerjee, S., Banish, D., Bank, A., Barbagelata, A., Barnard, D., Bellinger, R., Benn, A., Berk, M., Berry, B., Bethala, V., Bilazarian, S., Bisognano, J., Bleyer, F., Blum, M., Boehmer, J., Bouchard, A., Boyle, A., Bozkurt, B., Brown, C., Burlew, B., Burnham, K., Butler, J., Call, J., Cambier, P., Cappola, T., Carlson, R., Chandler, B., Chandra, R., Chandraratna, P., Chernick, R., Colan, D., Colfer, H., Colucci, W., Connelly, T., Costantini, O., Dadkhah, S., Dauber, I., Davis, J., Davis, S., Denning, S., Drazner, M., Dunlap, S., Egbujiobi, L., Elkayam, U., Elliott, J., El-Shahawy, M., Essandoh, L., Ewald, G., Fang, J., Farhoud, H., Felker, G., Fernandez, J., Festin, R., Fishbein, G., Florea, V., Flores, E., Floro, J., Gabris, M., Garg, M., Gatewood, R., Geller, M., Ghali, J., Ghumman, W., Gibbs, G., Gillespie, E., Gilmore, R., Gogia, H., Goldberg, L., Gradus-Pizlo, I., Grainger, T., Gudmundsson, G., Gunawardena, D., Gupta, D., Hack, T., Hall, S., Hamroff, G., Hankins, S., Hanna, M., Hargrove, J., Haught, W., Hauptman, P., Hazelrigg, M., Herzog, C., Heywood, J., Hill, T., Hilton, T., Hirsch, H., Hunter, J., Ibrahim, H., Imburgia, M., Iteld, B., Jackson, B., Jaffrani, N., Jain, D., Jain, A., James, M., Jimenez, J., Johnson, E., Kale, P., Kaneshige, A., Kapadia, S., Karia, D., Karlsberg, R., Katholi, R., Kerut, E., Khoury, W., Kipperman, R., Klapholz, M., Kosinski, E., Kozinn, M., Kraus, D., Krueger, S., Krum, H., Kumar, S., Lader, E., Lee, C., Levy, W., Lewis, E., Light-McGroary, K., Loh, I., Lombardi, W., Machado, C., Maislos, F., Mancini, D., Markus, T., Mather, P., McCants, K., McGrew, F., McLaurin, B., McMillan, E., McNamara, D., Meyer, T., Meymandi, S., Miller, A., Minami, E., Modi, M., Mody, F., Mohanty, P., Moscoso, R., Moskowitz, R., Moustafa, M., Mullen, M., Naz, T., Noonan, T., OʼBrien, T., Oellerich, W., Oren, R., Pamboukian, S., Pereira, N., Pitt, W., Porter, C., Prabhu, S., Promisloff, S., Ratkovec, R., Richardson, R., Ross, A., Saleh, N., Saltzberg, M., Sarkar, S., Schmedtje, J., Schneider, R., Schuyler, G., Shanes, J., Sharma, A., Siegel, C., Siegel, R., Silber, D., Singh, V., Singh, N., Singh, J., Sklar, J., Small, R., Smith, A., Smith, E., Smith, E., Smull, D., Sotolongo, R., Staniloae, C., Stapleton, D., Steele, P., Stehlik, J., Stein, M., Tang, W., Thadani, U., Torre-Amoine, G., Trichon, B., Tsai, C., Tummala, R., Van Bakel, A., Vicari, R., Vijay, N., Vijayaraghavan, K., Vittorio, T., Vossler, M., Wagoner, L., Wallis, D., Ward, N., Widmer, M., Wight, J., Wilkins, C., Williams, C., Williams, G., Winchester, M., Winkel, E., Wittmer, B., Wood, D., Wormer, D., Wright, R., Xu, Z., Yasin, M., and Zolty, R.

Published
2013
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9. Global Estimates of PBL Depth from Space-Borne LIDAR

Author

McGrath-Spangler, Erica lynn, Denning, S, Molod, A, and Ott, L

Subjects
Geophysics
Abstract

The planetary boundary layer (PBL) is responsible for communicating the exchange of energy, moisture, momentum, pollutants, and aerosols between the surface and the free atmosphere and is therefore crucial to many studies of the atmosphere. Unfortunately, there have historically been few observations of this important layer due to the complexity involved in its measurement. However, with the advent of more advanced satellites, global measurements of the PBL are now becoming possible. The PBL is often characterized by a high concentration of aerosols within the layer and low level clouds capping it and these are observable from space. The Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO) satellite was launched in 2006 with the intention of observing aerosols and clouds and was the first space-based LIDAR optimized for this purpose. CALIPSO observations are therefore well suited to observing the depth of the PBL. Since it was launched, CALIPSO has been making nearly continuous measurements enabling a global picture of PBL depth. We plan to present a global PBL depth product and how it evolves throughout the year. The product is able to identify deeper PBL depths in the summer hemisphere over land and deeper depths along the northern hemisphere oceanic storm tracks in winter associated with cold air traveling over warm water. Large seasonal cycles are also evident in the subtropical desert locations among other features. In addition, comparisons will be made between several estimates of PBL depth based on turbulent intensity, meteorology profiles, and aerosol profiles from the GEOS5 model.

Published
2012

16. Treatment of Anemia with Darbepoetin Alfa in Systolic Heart Failure

Author

Karl Swedberg, James B. Young, Inder S. Anand, Sunfa Cheng, Akshay S. Desai, Rafael Diaz, Aldo P. Maggioni, John J. V. McMurray, Christopher O'Connor, Marc A. Pfeffer, Scott D. Solomon, Yan Sun, Michal Tendera, Dirk J. van Veldhuisen, Young J, Grinfeld L, Krum H, Vanhaecke J, Olivera Clausell N, Goudev A, Howlett J, Corbalan R, Hradec J, Kober L, Eha J, Cohen Solal A, Anker SD, Chopra V, Lewis B, Erglis A, Sakalyte G, Cardona Munoz E, Dunselman P, Dickstein K, Ponikowski P, Seabra Gomes R, Apetrei E, Mareev V, Murin J, Dalby A, Lopez Sendon J, Willenheimer R, Cleland J, Adams K, Anand I, Butler J, Dunlap M, Felker M, Ghali J, Levy W, Carson P, Cohn J, Drexler H, Pocock S, Ryden L, Poole Wilson P, Fishbane S, Ivanovich P, Nissenson A, Katz S, Barkoudah E, Campbell P, Desai A, Finn PV, Hartley L, Kasabov R, Odutayo KA, Rajesh V, Solomon S, Weinrauch LA, Albizem M, Cheng S, Chou W, Deegenaars M, Dougherty M, Fouqueray B, Froissart M, Froment A, Gadd S, Ghosh S, Grazette L, Guillet S, Gulabani D, Haddock B, Harris C, Jaffer A, Kerns C, Kim J, Knussel B, Law H, Mather R, Mix C, Moore L, Moyes R, Polu K, Rossert J, Scarlata D, Smirnakis K, Smith L, Snyder W, Sun Y, Trotman ML, Wasserman S, Watkins A, Wong M, Zhang Y, Amuchastegui M, Belziti C, Bluguermann J, Caccavo M, Cartasegna L, Colque R, Cuneo C, Fernandez A, Gabito A, Goicochea R, Gonzalez M, Gorosito V, Hominal M, Kevorkian R, Litvak Bruno M, Llanos J, Mackinnon I, Manuale O, Marzetti E, Nul D, Perna E, Riccitelli M, Sanchez A, Santos D, Schygiel P, Toblli J, Vogel D, Aggarwal A, Amerena J, De Looze F, Fletcher P, Hare D, Ireland M, Lattimore J, Marwick T, Sindone A, Thompson P, Waites J, Altenberger J, Ebner C, Lenz K, Pacher R, Poelzl G, Charlier F, de Ceuninck M, De Keulenaer G, Dendale P, Maréchal P, Mullens W, Thoeng J, Vanderheyden M, Weytjens C, Wollaert B, Albuquerque D, Almeida D, Aspe y. Rosas J, Bocchi E, Bordignon S, Clausell N, Kaiser S, Leaes P, Martins Alves S, Montera M, Moura L, Pereira de Castro R, Rassi S, Reis A, Saraiva J, Simões M, Souza Neto J, Teixeira M, Benov H, Chompalova B, Donova T, Georgiev P, Gotchev D, Grigorov M, Guenova D, Hergeldjieva V, Ivanov D, Kostova E, Manolova A, Marchev S, Nikolov F, Popov A, Raev D, Tzekova M, Czarnecki W, Giannetti N, Haddad H, Heath J, Huynh T, Lepage S, Liu P, Lonn E, Ma P, Manyari D, Moe G, Parker J, Pesant Y, Rajda M, Ricci J, Roth S, Sestier F, Sluzar V, Sussex B, Vizel S, Antezana G, Bugueno C, Castro P, Conejeros C, Manriquez L, Martinez D, Potthoff S, Stockins B, Vukasovic J, Gregor P, Herold M, Jerabek O, Jirmar R, Kuchar R, Linhart A, Podzemska B, Soucek M, Spac J, Spacek R, Vodnansky P, Bronnum Schou J, Clemmensen K, Egstrup K, Jensen G, Kjoller Hansen L, Markenvard J, Rokkedal J, Skagen K, Torp Pedersen C, Tuxen C, Videbak L, Laks T, Vahula V, Harjola V, Kettunen R, Kotila M, Bauer F, Coisne D, Davy J, De Groote P, Dos Santos P, Funck F, Galinier M, Gibelin P, Isnard R, Neuder Y, Roul G, Sabatier R, Trochu J, Denny S, Dreykluft T, Flesch M, Genth Zotz S, Hambrecht R, Hein J, Jeserich M, John M, Kreider Stempfle H, Laufs U, Muellerleile K, Natour M, Sandri M, Schäufele T, von Hodenberg E, Weyland K, Winkelmann B, Tse H, Yan B, Barsi B, Csikasz J, Dezsi C, Edes I, Forster T, Karpati P, Kerekes C, Kis E, Kosa I, Lupkovics G, Nagy A, Preda I, Ronaszeki A, Tomcsanyi J, Zamolyi K, Agarwal D, Bahl V, Bordoloi A, Chockalingam K, Chopda M, Dugal J, Ghaisas N, Grant P, Hiremath S, Iyengar S, Jagadeesa Subramania B, Jain P, Joshi A, Khan A, Mullasari A, Naik S, Oomman A, Pai V, Pareppally Gopal R, Parikh K, Patel T, Prakash V, Sastry B, Sathe S, Sinha N, Srikanthan V, Subburamakrishnan P, Thacker H, Wander G, Admon D, Katz A, Klainman E, Marmor A, Moriel M, Mosseri M, Shotan A, Weinstein J, Zimlichman R, Agostoni P, Albanese M, Alunni G, Bini R, Boccanelli A, Bolognese L, Campana C, Carbonieri E, Carpino C, Checco L, Cosmi F, Angelo GD, De Cristofaro M, Floresta A, Fucili A, Galvani M, Ivleva A, Marra S, Musca G, Peccerillo N, Picchio E, Russo T, Scelsi L, Senni M, Tavazzi L, Jasinkevica I, Kakurina N, Veze I, Volans E, Bagdonas A, Berukstis E, Celutkiene J, Dambrauskaite A, Jarasuniene D, Luksiene D, Rudys A, Sliaziene S, Aguilar Romero R, Cardona Muñoz E, Castro Jimenez J, Chavez Herrera J, Chuquiure Valenzuela E, De la Pena G, Herrera E, Leiva Pons J, Lopez Alvarado A, Mendez Machado G, Ramos Lopez G, Basart D, Buijs E, Cornel J, de Leeuw M, Dijkgraaf R, Freericks M, Hamraoui K, Lenderlink T, Linssen G, Lodewick P, Lodewijks C, Lok D, Nierop P, Ronner E, Somsen A, van Dantzig J, van der Burgh P, van Kempen L, van Vlies B, Voors A, Wardeh A, Willems F, Gundersen T, Hole T, Thalamus J, Westheim A, Dabrowski M, Gorski J, Korewicki J, Kuc K, Miekus P, Musial W, Niegowska J, Piotrowski W, Podolec P, Polonski L, Rynkiewicz A, Szelemej R, Trusz Gluza M, Ujda M, Wojciechowski D, Wysokinski A, Camacho A, Fonseca C, Monteiro P, Bruckner I, Carasca E, Coman I, Datcu M, Dragulescu S, Ionescu P, Iordachescu Petica D, Manitiu I, Popa V, Pop Moldovan A, Radoi M, Stamate S, Tomescu M, Vita I, Aroutiounov G, Ballyuzek M, Bart B, Churina S, Glezer M, Goloshchekin B, Kobalava Z, Kostenko V, Lopatin Y, Martynov A, Orlov V, Semernin E, Shogenov Z, Sidorenko B, Skvortsov A, Storzhakov G, Sulimov V, Talibov O, Tereshenko S, Tsyrline V, Zadionchenko V, Zateyshchikov D, Dzupina A, Hranai M, Kmec J, Micko K, Pella D, Sojka G, Spisak V, Vahala P, Vinanska D, Badat A, Bayat J, Dawood S, Delport E, Ellis G, Garda R, Klug E, Mabin T, Naidoo D, Pretorius M, Ranjith N, Van Zyl L, Weich H, Anguita M, Berrazueta J, Bruguera i. 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D, Davy, J, De Groote, P, Dos Santos, P, Funck, F, Galinier, M, Gibelin, P, Isnard, R, Neuder, Y, Roul, G, Sabatier, R, Trochu, J, Denny, S, Dreykluft, T, Flesch, M, Genth Zotz, S, Hambrecht, R, Hein, J, Jeserich, M, John, M, Kreider Stempfle, H, Laufs, U, Muellerleile, K, Natour, M, Sandri, M, Schäufele, T, von Hodenberg, E, Weyland, K, Winkelmann, B, Tse, H, Yan, B, Barsi, B, Csikasz, J, Dezsi, C, Edes, I, Forster, T, Karpati, P, Kerekes, C, Kis, E, Kosa, I, Lupkovics, G, Nagy, A, Preda, I, Ronaszeki, A, Tomcsanyi, J, Zamolyi, K, Agarwal, D, Bahl, V, Bordoloi, A, Chockalingam, K, Chopda, M, Dugal, J, Ghaisas, N, Grant, P, Hiremath, S, Iyengar, S, Jagadeesa Subramania, B, Jain, P, Joshi, A, Khan, A, Mullasari, A, Naik, S, Oomman, A, Pai, V, Pareppally Gopal, R, Parikh, K, Patel, T, Prakash, V, Sastry, B, Sathe, S, Sinha, N, Srikanthan, V, Subburamakrishnan, P, Thacker, H, Wander, G, Admon, D, Katz, A, Klainman, E, Marmor, A, Moriel, M, Mosseri, M, Shotan, A, Weinstein, J, Zimlichman, 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J, Westheim, A, Dabrowski, M, Gorski, J, Korewicki, J, Kuc, K, Miekus, P, Musial, W, Niegowska, J, Piotrowski, W, Podolec, P, Polonski, L, Rynkiewicz, A, Szelemej, R, Trusz Gluza, M, Ujda, M, Wojciechowski, D, Wysokinski, A, Camacho, A, Fonseca, C, Monteiro, P, Bruckner, I, Carasca, E, Coman, I, Datcu, M, Dragulescu, S, Ionescu, P, Iordachescu Petica, D, Manitiu, I, Popa, V, Pop Moldovan, A, Radoi, M, Stamate, S, Tomescu, M, Vita, I, Aroutiounov, G, Ballyuzek, M, Bart, B, Churina, S, Glezer, M, Goloshchekin, B, Kobalava, Z, Kostenko, V, Lopatin, Y, Martynov, A, Orlov, V, Semernin, E, Shogenov, Z, Sidorenko, B, Skvortsov, A, Storzhakov, G, Sulimov, V, Talibov, O, Tereshenko, S, Tsyrline, V, Zadionchenko, V, Zateyshchikov, D, Dzupina, A, Hranai, M, Kmec, J, Micko, K, Pella, D, Sojka, G, Spisak, V, Vahala, P, Vinanska, D, Badat, A, Bayat, J, Dawood, S, Delport, E, Ellis, G, Garda, R, Klug, E, Mabin, T, Naidoo, D, Pretorius, M, Ranjith, N, Van Zyl, L, Weich, H, Anguita, M, Berrazueta, J, Bruguera i., Cortada J, de Teresa, E, Gómez Sánchez, M, González Juanatey, J, Gonzalez Maqueda, I, Jordana, R, Lupon, J, Manzano, L, Pascual Figal, D, Pulpón, L, Recio, J, Ridocci Soriano, F, Rodríguez Lambert, J, Roig Minguell, E, Romero, J, Valdovinos, P, Klintberg, L, Kronvall, T, Lycksell, M, Morner, S, Rydberg, E, Swedberg, K, Timberg, I, Wikstrom, G, Moccetti, T, Ashok, J, Banerjee, P, Carr White, G, Connolly, E, Francis, M, Greenbaum, R, Kadr, H, Lindsay, S, Mcmurray, J, Megarry, S, Memon, A, Murdoch, D, Senior, R, Squire, I, Tan, L, Witte, K, Adamson, P, Adler, A, Altschul, L, Altschuller, A, Amirani, H, Andreou, C, Ansari, M, Antonishen, M, Banchs, H, Banerjee, S, Banish, D, Bank, A, Barbagelata, A, Barnard, D, Bellinger, R, Benn, A, Berk, M, Berry, B, Bethala, V, Bilazarian, S, Bisognano, J, Bleyer, F, Blum, M, Boehmer, J, Bouchard, A, Boyle, A, Bozkurt, B, Brown, C, Burlew, B, Burnham, K, Call, J, Cambier, P, Cappola, T, Carlson, R, Chandler, B, Chandra, R, Chandraratna, P, 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Light McGroary, K, Loh, I, Lombardi, W, Machado, C, Maislos, F, Mancini, D, Markus, T, Mather, P, Mccants, K, Mcgrew, F, Mclaurin, B, Mcmillan, E, Mcnamara, D, Meyer, T, Meymandi, S, Miller, A, Minami, E, Modi, M, Mody, F, Mohanty, P, Moscoso, R, Moskowitz, R, Moustafa, M, Mullen, M, Naz, T, Noonan, T, O., Brien T, Oellerich, W, Oren, R, Pamboukian, S, Pereira, N, Pitt, W, Porter, C, Prabhu, S, Promisloff, S, Ratkovec, R, Richardson, R, Ross, A, Saleh, N, Saltzberg, M, Sarkar, S, Schmedtje, J, Schneider, R, Schuyler, G, Shanes, J, Sharma, A, Siegel, C, Siegel, R, Silber, D, Singh, N, Singh, J, Singh, V, Sklar, J, Small, R, Smith, A, Smith, E, Smull, D, Sotolongo, R, Staniloae, C, Stapleton, D, Steele, P, Stehlik, J, Stein, M, Tang, W, Thadani, U, Torre Amoine, G, Trichon, B, Tsai, C, Tummala, R, Van Bakel, A, Vicari, R, Vijay, N, Vijayaraghavan, K, Vittorio, T, Vossler, M, Wagoner, L, Wallis, D, Ward, N, Widmer, M, Wight, J, Wilkins, C, Williams, C, Williams, G, Winchester, M, Winkel, E, Wittmer, B, Wood, D, Wormer, D, Wright, R, Xu, Z, Yasin, M, Zolty, R., Faculteit Medische Wetenschappen/UMCG, and Cardiovascular Centre (CVC)

Subjects
Male, CHRONIC KIDNEY-DISEASE, Darbepoetin alfa, Ciencias de la Salud, Kaplan-Meier Estimate, law.invention, Hemoglobins, DOUBLE-BLIND, Randomized controlled trial, law, hemic and lymphatic diseases, Treatment Failure, Hazard ratio, Ética Médica, Anemia, General Medicine, Middle Aged, Shock, Septic, Stroke, purl.org/becyt/ford/3 [https], Female, medicine.drug, medicine.medical_specialty, CIENCIAS MÉDICAS Y DE LA SALUD, Placebo, CONTROLLED-TRIAL, purl.org/becyt/ford/3.3 [https], MORBIDITY, Double-Blind Method, Darbepoetin, Internal medicine, Thromboembolism, parasitic diseases, medicine, Humans, Adverse effect, Erythropoietin, Aged, Proportional Hazards Models, CITY CARDIOMYOPATHY QUESTIONNAIRE, business.industry, Proportional hazards model, MORTALITY, equipment and supplies, medicine.disease, Surgery, REDUCTION, EPOETIN, Heart failure, Hematinics, business, Systolic heart failure, Heart Failure, Systolic
Abstract

BACKGROUND: Patients with systolic heart failure and anemia have worse symptoms, functional capacity, and outcomes than those without anemia. We evaluated the effects of darbepoetin alfa on clinical outcomes in patients with systolic heart failure and anemia. METHODS: In this randomized, double-blind trial, we assigned 2278 patients with systolic heart failure and mild-to-moderate anemia (hemoglobin level, 9.0 to 12.0 g per deciliter) to receive either darbepoetin alfa (to achieve a hemoglobin target of 13 g per deciliter) or placebo. The primary outcome was a composite of death from any cause or hospitalization for worsening heart failure. RESULTS: The primary outcome occurred in 576 of 1136 patients (50.7%) in the darbepoetin alfa group and 565 of 1142 patients (49.5%) in the placebo group (hazard ratio in the darbepoetin alfa group, 1.01; 95% confidence interval, 0.90 to 1.13; P=0.87). There was no significant between-group difference in any of the secondary outcomes. The neutral effect of darbepoetin alfa was consistent across all prespecified subgroups. Fatal or nonfatal stroke occurred in 42 patients (3.7%) in the darbepoetin alfa group and 31 patients (2.7%) in the placebo group (P=0.23). Thromboembolic adverse events were reported in 153 patients (13.5%) in the darbepoetin alfa group and 114 patients (10.0%) in the placebo group (P=0.01). Cancer-related adverse events were similar in the two study groups. CONCLUSIONS: Treatment with darbepoetin alfa did not improve clinical outcomes in patients with systolic heart failure and mild-to-moderate anemia. Our findings do not support the use of darbepoetin alfa in these patients. (Funded by Amgen; RED-HF ClinicalTrials.gov number, NCT00358215.). Fil: Swedberg, Karl. University of Gothenburg; Suecia Fil: Young, James B.. Cleveland Clinic; Estados Unidos Fil: Anand, Inder S.. University of Minnesota; Estados Unidos Fil: Cheng, Sunfa. Amgen; Estados Unidos Fil: Desai, Akshay S.. Brigham and Women’s Hospital; Estados Unidos Fil: Diaz, Rafael. Estudios Clínicos Latinoamérica; Argentina Fil: Maggioni, Aldo P.. Italian Association of Hospital Cardiologists Research Center; Italia Fil: McMurray, John J.V.. University of Glasgow; Reino Unido Fil: O’Connor, Christopher. University of Duke; Estados Unidos Fil: Pfeffer, Marc A.. Brigham and Women’s Hospital; Estados Unidos Fil: Solomon, Scott D.. Brigham and Women’s Hospital; Estados Unidos Fil: Sun, Yan. Amgen; Estados Unidos Fil: Tendera, Michal. Medical University of Silesia; Polonia Fil: van Veldhuisen, Dirk J.. University of Groningen; Países Bajos Fil: Toblli, Jorge Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina

Published
2013

17. Grand Challenges for Biological and Environmental Research: A Long-Term Vision

Author

Arkin, A., primary, Baliga, N., additional, Braam, J., additional, Church, G., additional, Collins, J, additional, Cottingham, R., additional, Ecker, J., additional, Gerstein, M., additional, Gilna, P., additional, Greenberg, J., additional, Handelsman, J., additional, Hubbard, S., additional, Joachimiak, A., additional, Liao, J., additional, Looger, L., additional, Meyerowitz, E., additional, Mjolness, E., additional, Petsko, G., additional, Sayler, G., additional, Simpson, M., additional, Stacey, G., additional, Sussman, M., additional, Tiedje, J., additional, Bader, D., additional, Cessi, P., additional, Collins, W., additional, Denning, S., additional, Dickinson, R., additional, Easterling, D., additional, Edmonds, J., additional, Feddema, J., additional, Field, C., additional, Fridlind, A., additional, Fung, I., additional, Held, I., additional, Jackson, R., additional, Janetos, A., additional, Large, W., additional, Leinen, M., additional, Leung, R., additional, Long, S., additional, Mace, G., additional, Masiello, C., additional, Meehl, G., additional, Ort, D., additional, Otto-Bliesner, B., additional, Penner, J., additional, Prather, M., additional, Randall, D., additional, Rasch, P., additional, Schneider, E., additional, Shugart, H., additional, Thornton, P., additional, Washington, W., additional, Wildung, R., additional, Wiscombe, W., additional, Zak, D., additional, Zhang, M., additional, Bielicki, J., additional, Buford, M., additional, Cleland, E., additional, Dale, V., additional, Duke, C., additional, Ehleringer, J., additional, Hecht, A., additional, Kammen, D., additional, Marland, G., additional, Pataki, D., additional, and Riley, M. Robertson, P., additional

Published
2010
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18. A genetic analysis of gemcitabine-induced high-grade neutropenia in pancreatic cancer patients

Author

Innocenti, F., primary, Jiang, C., additional, Sibley, A.B., additional, Denning, S., additional, Etheridge, A.S., additional, Watson, D., additional, Niedzwiecki, D., additional, Hatch, A.J., additional, Hurwitz, H., additional, Nixon, A., additional, Furukawa, Y., additional, Kubo, M., additional, Crona, D.J., additional, Kindler, H., additional, McLeod, H.L., additional, Ratain, M.J., additional, and Owzar, K., additional

Published
2018
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22. Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial

Author

Nicholls, Stephen J., Kastelein, John J. P., Schwartz, Gregory G., Bash, Dianna, Rosenson, Robert S., Cavender, Matthew A., Brennan, Danielle M., Koenig, Wolfgang, Jukema, J. Wouter, Nambi, Vijay, Wright, R. Scott, Menon, Venu, Lincoff, A. Michael, Nissen, Hennekens C, Steven E., Brown, Wv, Demets, D, Pfeffer, M, Roleau, J, Abraham, J, Gebel, J, Huff, C, Katzan, I, Shishehbor, M, Rassi, A, Uchino, K, Vest, A, Zishiri, E, Heckman, Mj, Balog, C, Dart, A, Amerena, J, Prasad, C, Farshid, A, Gunalingam, B, Thompson, P, Collins, N, Arstall, M, van Gaal, W, Aroney, C, Mahar, L, Youssef, G, Horowitz, J, Anand, D, Rodes-Cabau, J, Polasek, P, Lai, C, Huynh, T, Hubacek, J, Kokis, A, Paradis, Jm, Mukherjee, A, Senaratne, M, Constance, C, Gosselin, G, Lavi, S, Parker, J, Zadra, R, Abramson, B, Della-Siega, A, Spinar, J, Pudil, R, Motovska, Z, Maly, M, Hutyra, M, Pleva, L, Mayer, O, Semenka, J, Klimovic, T, Horak, D, Cervinka, P, Klimsa, Z, Hulinsky, V, Reichert, P, Monhart, Z, Rotterova, H, Kobulia, B, Shaburishvili, T, Mamatsashvili, M, Chapidze, G, Chumburidze, V, Megreladze, I, Khintibidze, I, Leithäuser, B, Voehringer, Hf, Wachter, R, Nogai, K, Lapp, H, Haltern, G, Gielen, S, Dorsel, T, Möllmann, H, Stellbrink, C, Hengstenberg, C, Dengler, T, Heuer, H, Kreuzer, J, Leschke, M, Mudra, H, Werner, N, Braun-Dullaeus, R, Rosenberg, M, Frey, N, Koenig, W, Strasser, R, Genth-Zotz, S, Kiss, R, Nagy, A, Kovacs, Z, Csapo, K, Edes, I, Sereg, M, Vertes, A, Ronaszeki, A, Kancz, S, Benczur, B, Polgar, P, Muller, G, Simonyi, G, Dezsi, C, Merkely, B, Dinnyes, J, Lupkovics, G, Kahali, D, Banker, D, Trivedi, S, Rajput, R, Premchand, R, Dani, S, Vadaganelli, P, Gupta, S, Chandra, S, Fulwani, M, Chawla, K, Parikh, K, Prati, F, Speciale, G, Valgimigli, M, Suriano, P, Sangiorgi, G, Fineschi, M, Merenda, R, Marenzi, G, Berti, S, Corrada, E, Cuccia, C, Testa, R, Moretti, L, Mennuni, M, Biasucci, Lm, Lioy, E, Auguadro, C, Magagnini, E, Fedele, F, Piscione, F, Azar, R, Trip, Md, Liem, A, den Hartoog, M, Lenderink, T, van de Wetering ML, Lok, D, Oei, F, Tans, Jg, Ilmer, B, Keijzers, M, Monraats, P, Kedhi, E, Breedveld, Rw, Herrman, J, van Wijk, L, Ronner, E, Nierop, P, Bosschaert, M, Hermans, W, Doevendans, P, Troquay, R, van der Heijden, R, Veen, G, Bokern, Mj, Bronzwaer, Pn, Kie, Sh, Den Hartog, F, Elliott, J, Wilkins, G, Hart, H, Devlin, G, Harding, S, Ponikowski, P, Madej, A, Kochmanski, M, Witkowski, A, Pluta, W, Bronisz, M, Kornacewicz-Jach, Z, Wysokinski, A, Ujda, M, Drozdz, J, Derlaga, B, Gessek, J, Dabrowski, M, Miekus, P, Kozlowski, A, Gniot, J, Musial, W, Dobrzycki, S, Rynkiewicz, A, Psuja, P, Rekosz, J, Drzewiecki, A, Kuznetsov, V, Gordeev, I, Goloshchekin, B, Markov, V, Barbarich, V, Belenky, D, Mikhin, V, Volkova, E, Timofeev, A, Ermoshkina, L, Barbarash, O, Klein, G, Libis, R, Vishnevsky, A, Linev, K, Khaisheva, L, Ruda, M, Dovgalevskiy, Y, Shvarts, Y, Zateyshchikov, D, Kostenko, V, Shalnev, V, Simanenkov, V, Arkhipov, M, Ovcharenko, E, Guseva, G, Akhunova, S, Ortiz, Ai, Navarro, Mj, Romero, Aj, Goya, Il, Peñaranda, As, Cendon, Aa, Rubio, Am, Zubiri, Jj, Soriano, Fr, Sanz, Rr, Genís, Ab, Lago, Vn, Fernández, Jd, Romo, Ai, Franco, Sn, Martin, Ih, Montero, Js, Martin Mde, M, González, Mj, Antolin, Jm, Areses, El, Miranda, Jm, Alonso-Pulpón, L, Esquivias, Gb, Jarne, Ef, Cortés, Jm, Pérez, Mb, Gormaz, Cl, Alegret, Jm, Nava, Js, Ingelmo, Jm, Urbano, Rh, Sanmartín, M, Katerenchuk, O, Vakaliuk, I, Karpenko, O, Prokhorov, O, Koval, O, Faynyk, A, Kopytsya, M, Karpenko, Y, Kraiz, I, Feskov, O, Rudenko, L, Kozhukhov, S, Goloborodko, B, Rivera, E, Broadwater, S, Crowley, S, Vijay, N, Goswami, R, Ferrier, L, Blanchard, A, Mccullum, K, Chernick, R, Bertolet, B, Battaglia, J, Richardson, J, Lochridge, S, Lieberman, S, Amkieh, A, Cavender, Jb, Denning, S, Treasure, C, Kmetzo, J, Stillabower, M, Brilakis, E, Schwartz, G, Acheatel, R, Kukuy, E, Ashchi, M, Skelding, K, Martin, L, Gillespie, E, French, W, Pollock, S, Polk, D, Black, R, Drenning, D, Anderson, J, Sanz, M, Korban, E, Wiley, M, Rezkalla, S, Minisi, A, Shah, A, Silverman, P, Amlani, M, Eaton, G, Brown, A, Jay, D, Loussararian, A, Lamas, G, Lauer, M, Williams, J, Asfour, A, Runquist, L, Robertson, R, Blonder, R, Davies, C, Downes, T, Chronos, N, Marso, S, Haldis, T, Eich, D, Ahmed, M, East, C, Macdonald, L, Seigel, P, White, M, Camp, A, Kleiman, N, Burtt, D, Strain, J, Go, B, Henry, P, Sultan, P, Delafontaine, P, Kashou, H, Lambert, C, Movahed, M, Saucedo, J, Thadani, U, Chandrashekhar, Y, Lu, D, Chandna, H, Mann, J, Ramaswamy, G, Browne, K, Janik, M, Cannon, K, Tolerico, P., Berni, Andrea, ACS - Amsterdam Cardiovascular Sciences, Vascular Medicine, and Cardiology

Subjects
Male, Indoles, Acetates, Acute Coronary Syndrome, Aged, Angina, Unstable, Atherosclerosis, Double-Blind Method, Early Termination of Clinical Trials, Female, Heptanoic Acids, Humans, Middle Aged, Phospholipases A, Phospholipases A2, Secretory, Pyrroles, Risk, Stroke, Survival Analysis, Treatment Outcome, Myocardial Infarction, law.invention, chemistry.chemical_compound, Randomized controlled trial, law, Atorvastatin, Clinical endpoint, Medicine (all), General Medicine, Angina, Keto Acids, medicine.medical_specialty, Acute coronary syndrome, Placebo, Unstable, Internal medicine, Multicenter trial, medicine, Atorvastatin Calcium, Unstable angina, business.industry, Secretory, medicine.disease, Interim analysis, Surgery, Phospholipases A2, chemistry, Varespladib, business
Abstract

Importance Secretory phospholipase A 2 (sPLA 2 ) generates bioactive phospholipid products implicated in atherosclerosis. The sPLA 2 inhibitor varespladib has favorable effects on lipid and inflammatory markers; however, its effect on cardiovascular outcomes is unknown. Objective To determine the effects of sPLA 2 inhibition with varespladib on cardiovascular outcomes. Design, Setting, and Participants A double-blind, randomized, multicenter trial at 362 academic and community hospitals in Europe, Australia, New Zealand, India, and North America of 5145 patients randomized within 96 hours of presentation of an acute coronary syndrome (ACS) to either varespladib (n = 2572) or placebo (n = 2573) with enrollment between June 1, 2010, and March 7, 2012 (study termination on March 9, 2012). Interventions Participants were randomized to receive varespladib (500 mg) or placebo daily for 16 weeks, in addition to atorvastatin and other established therapies. Main Outcomes and Measures The primary efficacy measure was a composite of cardiovascular mortality, nonfatal myocardial infarction (MI), nonfatal stroke, or unstable angina with evidence of ischemia requiring hospitalization at 16 weeks. Six-month survival status was also evaluated. Results At a prespecified interim analysis, including 212 primary end point events, the independent data and safety monitoring board recommended termination of the trial for futility and possible harm. The primary end point occurred in 136 patients (6.1%) treated with varespladib compared with 109 patients (5.1%) treated with placebo (hazard ratio [HR], 1.25; 95% CI, 0.97-1.61; log-rank P = .08). Varespladib was associated with a greater risk of MI (78 [3.4%] vs 47 [2.2%]; HR, 1.66; 95% CI, 1.16-2.39; log-rank P = .005). The composite secondary end point of cardiovascular mortality, MI, and stroke was observed in 107 patients (4.6%) in the varespladib group and 79 patients (3.8%) in the placebo group (HR, 1.36; 95% CI, 1.02-1.82; P = .04). Conclusions and Relevance In patients with recent ACS, varespladib did not reduce the risk of recurrent cardiovascular events and significantly increased the risk of MI. The sPLA 2 inhibition with varespladib may be harmful and is not a useful strategy to reduce adverse cardiovascular outcomes after ACS. Trial Registration clinicaltrials.gov Identifier:NCT01130246

Published
2014

24. Biosphere model simulations of interannual variability in terrestrial C-13/C-12 exchange

Author

van der Velde, Ivar, Miller, J. B., Schaefer, K., Masarie, K. A., Denning, S., White, J. W. C., Tans, P. P., Krol, M. C., Peters, W., Isotope Research, and Energy and Sustainability Research Institute Groni

Subjects
CLIMATE, carbon isotopes, PHOTOSYNTHESIS, ASSIMILATION, carbon cycle, biogeochemical modeling, STOMATAL CONDUCTANCE, CYCLE, ATMOSPHERIC CO2, CARBON-ISOTOPE DISCRIMINATION, C-13 DISCRIMINATION, OCEAN CO2 SINK, FIRES
Abstract

[1] Previous studies suggest that a large part of the variability in the atmospheric ratio of 13CO2/12CO2originates from carbon exchange with the terrestrial biosphere rather than with the oceans. Since this variability is used to quantitatively partition the total carbon sink, we here investigate the contribution of interannual variability (IAV) in biospheric exchange to the observed atmospheric 13C variations. We use the Simple Biosphere ‐ Carnegie‐Ames‐Stanford Approach biogeochemical model, including a detailed isotopic fractionation scheme, separate 12C and 13C biogeochemical pools, and satellite‐observed fire disturbances. This model of 12CO2 and 13CO2 thus also produces return fluxes of 13CO2from its differently aged pools, contributing to the so‐called disequilibrium flux. Our simulated terrestrial 13C budget closely resembles previously published model results for plant discrimination and disequilibrium fluxes and similarly suggests that variations in C3 discrimination and year‐to‐year variations in C3and C4 productivity are the main drivers of their IAV. But the year‐to‐year variability in the isotopic disequilibrium flux is much lower (1σ=±1.5 PgC ‰ yr−1) than required (±12.5 PgC ‰ yr−1) to match atmospheric observations, under the common assumption of low variability in net ocean CO2 fluxes. This contrasts with earlier published results. It is currently unclear how to increase IAV in these drivers suggesting that SiBCASA still misses processes that enhance variability in plant discrimination and relative C3/C4productivity. Alternatively, 13C budget terms other than terrestrial disequilibrium fluxes, including possibly the atmospheric growth rate, must have significantly different IAV in order to close the atmospheric 13C budget on a year‐to‐year basis.

Published
2013

25. Biosphere model simulations of interannual variability in terrestrial 13C/12C exchange

Author

van der Velde, I. R., Miller, J. B., Schaefer, K., Masarie, K. A., Denning, S., White, J. W. C., Tans, P. P., Krol, M. C., and Peters, W.

Subjects
Meteorologie en Luchtkwaliteit, atmospheric co2, WIMEK, assimilation, photosynthesis, Meteorology and Air Quality, cycle, c-13 discrimination, fires, ocean co2 sink, stomatal conductance, climate, carbon-isotope discrimination
Abstract

Previous studies suggest that a large part of the variability in the atmospheric ratio of (CO2)-C-13/(12)CO(2)originates from carbon exchange with the terrestrial biosphere rather than with the oceans. Since this variability is used to quantitatively partition the total carbon sink, we here investigate the contribution of interannual variability (IAV) in biospheric exchange to the observed atmospheric C-13 variations. We use the Simple Biosphere - Carnegie-Ames-Stanford Approach biogeochemical model, including a detailed isotopic fractionation scheme, separate C-12 and C-13 biogeochemical pools, and satellite-observed fire disturbances. This model of (CO2)-C-12 and (CO2)-C-13 thus also produces return fluxes of (13)CO(2)from its differently aged pools, contributing to the so-called disequilibrium flux. Our simulated terrestrial C-13 budget closely resembles previously published model results for plant discrimination and disequilibrium fluxes and similarly suggests that variations in C-3 discrimination and year-to-year variations in C(3)and C-4 productivity are the main drivers of their IAV. But the year-to-year variability in the isotopic disequilibrium flux is much lower (1 sigma=1.5PgCyr(-1)) than required (12.5PgCyr(-1)) to match atmospheric observations, under the common assumption of low variability in net ocean CO2 fluxes. This contrasts with earlier published results. It is currently unclear how to increase IAV in these drivers suggesting that SiBCASA still misses processes that enhance variability in plant discrimination and relative C-3/C(4)productivity. Alternatively, C-13 budget terms other than terrestrial disequilibrium fluxes, including possibly the atmospheric growth rate, must have significantly different IAV in order to close the atmospheric C-13 budget on a year-to-year basis.

Published
2013

26. Letter tot the editor: Iconic CO2 Time Series at Risk

Author

Houweling, S., Badawy, B., Baker, D.F., Basu, S., Belikov, D., Bergamaschi, P., Bousquet, P., Broquet, G., Butler, T., Canadell, J.G., Chen, J., Chevallier, F., Ciais, P., Collatz, G.J., Denning, S., Engelen, R., Enting, I.G., Fischer, M.L., Fraser, A., Gerbig, C., Gloor, M., Jacobson, A.R., Jones, D.B.A., Heimann, M., Khalil, A., Kaminski, T., Kasibhatla, P.S., Krakauer, N.Y., Krol, M., Maki, T., Maksyutov, S., Manning, A., Meesters, A., Miller, J.B., Palmer, P.I., Patra, P., Peters, W., Peylin, P., Poussi, Z., Prather, M.J., Randerson, J.T., Rockmann, T., Rodenbeck, C., Sarmiento, J.L., Schimel, D.S., Scholze, M., Schuh, A., Suntharalingam, P., Takahashi, T., Turnbull, J., Yurganov, L., and Vermeulen, A.

Subjects
Meteorologie en Luchtkwaliteit, WIMEK, Meteorology and Air Quality, Life Science
Published
2012

27. Iconic CO2 Time Series at Risk

Author

Houweling, S., Badawy, B., Baker, D. F, Basu, S., Belikov, D., Bergamaschi, P., Bousquet, P., Broquet, G., Butler, T., Canadell, J. G, Chen, J., Chevallier, F., Ciais, P., Collatz, G. J, Denning, S., Engelen, R., Enting, I. G, Fischer, M. L, Fraser, A., Gerbig, C., Gloor, M., Jacobson, A. R, Jones, D. B. A, Heimann, M., Khalil, A., Kaminski, T., Kasibhatla, P. S, Krakauer, N. Y, Krol, M., Maki, T., Maksyutov, S., Manning, A., Meesters, A., Miller, J. B, Palmer, P. I, Patra, P., Peters, W., Peylin, P., Poussi, Z., Prather, M. J, Randerson, J. T, Rockmann, T., Rodenbeck, C., Sarmiento, J. L, Schimel, D. S, Scholze, M., Schuh, A., Suntharalingam, P., Takahashi, T., Turnbull, J., Yurganov, L., Vermeulen, A., Houweling, S., Badawy, B., Baker, D. F, Basu, S., Belikov, D., Bergamaschi, P., Bousquet, P., Broquet, G., Butler, T., Canadell, J. G, Chen, J., Chevallier, F., Ciais, P., Collatz, G. J, Denning, S., Engelen, R., Enting, I. G, Fischer, M. L, Fraser, A., Gerbig, C., Gloor, M., Jacobson, A. R, Jones, D. B. A, Heimann, M., Khalil, A., Kaminski, T., Kasibhatla, P. S, Krakauer, N. Y, Krol, M., Maki, T., Maksyutov, S., Manning, A., Meesters, A., Miller, J. B, Palmer, P. I, Patra, P., Peters, W., Peylin, P., Poussi, Z., Prather, M. J, Randerson, J. T, Rockmann, T., Rodenbeck, C., Sarmiento, J. L, Schimel, D. S, Scholze, M., Schuh, A., Suntharalingam, P., Takahashi, T., Turnbull, J., Yurganov, L., and Vermeulen, A.

Abstract

The steady rise in atmospheric long-lived greenhouse gas concentrations is the main driver of contemporary climate change. The Mauna Loa CO2time series (1,2), started by C. D. Keeling in 1958 and maintained today by the Scripps Institution of Oceanography and the Earth System Research Laboratory (ESRL) of NOAA, is iconic evidence of the effect of human-caused fossil fuel and land-use change emissions on the atmospheric increase of CO2. The continuity of such records depends critically on having stable funding, which is challenging to maintain in the context of 3- to 4-year research grant funding cycles (3), and is currently threatened by the financial crisis. The ESRL Global Monitoring Division maintains a network of about 100 surface and aircraft sites worldwide at which whole air samples are collected approximately every week for analysis of CO2, CH4, CO, halocarbons, and many other chemical species (4). This is complemented by high-frequency measurements at the Mauna Loa, Barrow, American Samoa, and South Pole observatories, and about 10 North American tall towers. The success of the NOAA program has inspired similar efforts in Europe (5), China (6), India (7), and Brazil (8), with the United Nations World Meteorological Organization providing guidance and precision requirements through the Global Atmosphere Watch program (9), but no funding. The data collected by NOAA and its worldwide partners have been used not only to demonstrate the unassailable rise of atmospheric greenhouse gas concentrations, but also to infer the magnitudes, locations, and times of surface-atmosphere exchange of those gases based on small concentration gradients between sites (10). Important findings from analysis of these records include the detection of a significant terrestrial carbon sink at northern mid-latitudes (11) and subsequent research aimed at identifying the mechanisms by which that sink must operate. Long-term, high-quality, atmospheric measurements are crucial for quanti

Published
2012

28. Corrigendum to “Incorporation of crop phenology in Simple Biosphere Model (SiBcrop) to improve land-atmosphere carbon exchanges from croplands” published in Biogeosciences, 6, 969–986, 2009

Author

Lokupitiya, Erandathie, Denning, S., Paustian, K., Baker, I., Schaefer, K., Verma, Shashi B., Meyers, T., Bernacchi, C. J., Suyker, Andrew E., Fischer, M. L., Lokupitiya, Erandathie, Denning, S., Paustian, K., Baker, I., Schaefer, K., Verma, Shashi B., Meyers, T., Bernacchi, C. J., Suyker, Andrew E., and Fischer, M. L.

Abstract

In the above mentioned manuscript a mistake in Fig. 11 occured. The corrected version of the figure is as follows.

Published
2009

29. Incorporation of crop phenology in Simple Biosphere Model (SiBcrop) to improve land-atmosphere carbon exchanges from croplands

Author

Lokupitiya, Erandathie, Denning, S., Paustian, K., Baker, I., Schaefer, K., Verma, Shashi B., Meyers, T., Bernacchi, C. J., Suyker, Andrew E., Fischer, M. L., Lokupitiya, Erandathie, Denning, S., Paustian, K., Baker, I., Schaefer, K., Verma, Shashi B., Meyers, T., Bernacchi, C. J., Suyker, Andrew E., and Fischer, M. L.

Abstract

Croplands are man-made ecosystems that have high net primary productivity during the growing season of crops, thus impacting carbon and other exchanges with the atmosphere. These exchanges play a major role in nutrient cycling and climate change related issues. An accurate representation of crop phenology and physiology is important in land-atmosphere carbon models being used to predict these exchanges. To better estimate time-varying exchanges of carbon, water, and energy of croplands using the Simple Biosphere (SiB) model, we developed crop-specific phenology models and coupled them to SiB. The coupled SiBphenology model (SiBcrop) replaces remotely-sensed NDVI information, on which SiB originally relied for deriving Leaf Area Index (LAI) and the fraction of Photosynthetically Active Radiation (fPAR) for estimating carbon dynamics. The use of the new phenology scheme within SiB substantially improved the prediction of LAI and carbon fluxes for maize, soybean, and wheat crops, as compared with the observed data at several AmeriFlux eddy covariance flux tower sites in the US mid continent region. SiBcrop better predicted the onset and end of the growing season, harvest, interannual variability associated with crop rotation, day time carbon uptake (especially for maize) and day to day variability in carbon exchange. Biomass predicted by SiBcrop had good agreement with the observed biomass at field sites. In the future, we will predict fine resolution regional scale carbon and other exchanges by coupling SiBcrop with RAMS (the Regional Atmospheric Modeling System). A Corrigendum is attached (below).

Published
2009

31. Corrigendum to "Incorporation of crop phenology in Simple Biosphere Model (SiBcrop) to improve land-atmosphere carbon exchanges from croplands" published in Biogeosciences, 6, 969–986, 2009

Author

Lokupitiya, E., primary, Denning, S., additional, Paustian, K., additional, Baker, I., additional, Schaefer, K., additional, Verma, S., additional, Meyers, T., additional, Bernacchi, C. J., additional, Suyker, A., additional, and Fischer, M., additional

Published
2009
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33. The Vulcan Project: Methods, results, and evaluation

Author

Gurnev, Kevin, primary, Mendoza, D, additional, Miller, C, additional, Fischer, M, additional, Corbin, K, additional, Ojima, D, additional, Knox, S, additional, Denning, S, additional, Can, S de la Rue du, additional, Geethakumar, S, additional, and Ilyushchenko, S, additional

Published
2009
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37. Development of a novel walk-through fly trap for the control of horn flies and other pests on pastured dairy cows.

Author

Denning, S. S., Washburn, S. P., and Watson, D. W.

Subjects
*HORN fly, *FACE fly, *STABLE fly, *CATTLE, *DAIRY farm management
Abstract

A prototype walk-through fly vacuum system, designed to remove horn flies Haematobia irritans (L.) (Diptera: Muscidae) from cattle, was developed and tested for efficacy. The study was conducted during 4 fly seasons over 17 consecutive weeks each year within the months of May through September at 1 dairy research herd in the coastal plain of North Carolina. Additional data on horn flies, as well as face flies (Musca autumnalis) and stable flies (Stomoxys calcitrans), were collected during 1 yr from 7 commercial pasture-based and organic dairy farms in the piedmont region of North Carolina. The number of flies observed on animals in the pasture was compared with the number of flies collected in the trap. Studies were initiated after horn fly densities had met or exceeded a threshold of 200 flies per animal. The vacuum trap removed between 1.3 and 2.5 million flies annually from the research station cattle. Most fly removal occurred during the first few weeks of operation and maintained densities below threshold thereafter. Cattle using the fly trap at the research farm had only about 28% the number of horn flies as untreated cattle, and reductions ranged from 67.5 to 74.5% across the 4-yr study. In addition to large numbers of horn flies, traps placed on commercial dairies during 1 yr collected stable flies, face flies, and house flies, all species with differing behavior and larger in size than horn flies. The estimated cost of running the trap is $72 per season at commercial rates of $0.12 per hour and an expected 4 h of daily operation during the time of milking. Use of a vacuum system as described herein has potential as a cost-effective method in reducing populations of parasitic flies in pasture-based dairy production systems without the use of insecticides. [ABSTRACT FROM AUTHOR]

Published
2014
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38. Biosphere model simulations of interannual variability in terrestrial 13C/12C exchange.

Author

van der Velde, I. R., Miller, J. B., Schaefer, K., Masarie, K. A., Denning, S., White, J. W. C., Tans, P. P., Krol, M. C., and Peters, W.

Subjects
BIOSPHERE, LIGHT elements, GAIA hypothesis, ATMOSPHERE, LIFE (Biology)
Abstract

Previous studies suggest that a large part of the variability in the atmospheric ratio of 13CO2/12CO2originates from carbon exchange with the terrestrial biosphere rather than with the oceans. Since this variability is used to quantitatively partition the total carbon sink, we here investigate the contribution of interannual variability (IAV) in biospheric exchange to the observed atmospheric 13C variations. We use the Simple Biosphere - Carnegie-Ames-Stanford Approach biogeochemical model, including a detailed isotopic fractionation scheme, separate 12C and 13C biogeochemical pools, and satellite-observed fire disturbances. This model of 12CO2 and 13CO2 thus also produces return fluxes of 13CO2from its differently aged pools, contributing to the so-called disequilibrium flux. Our simulated terrestrial 13C budget closely resembles previously published model results for plant discrimination and disequilibrium fluxes and similarly suggests that variations in C3 discrimination and year-to-year variations in C3and C4 productivity are the main drivers of their IAV. But the year-to-year variability in the isotopic disequilibrium flux is much lower (1 σ=±1.5 PgC ‰ yr−1) than required (±12.5 PgC ‰ yr−1) to match atmospheric observations, under the common assumption of low variability in net ocean CO2 fluxes. This contrasts with earlier published results. It is currently unclear how to increase IAV in these drivers suggesting that SiBCASA still misses processes that enhance variability in plant discrimination and relative C3/C4productivity. Alternatively, 13C budget terms other than terrestrial disequilibrium fluxes, including possibly the atmospheric growth rate, must have significantly different IAV in order to close the atmospheric 13C budget on a year-to-year basis. [ABSTRACT FROM AUTHOR]

Published
2013
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40. Evidence for susceptibility of intrathymic T-cell precursors and their progeny carrying T-cell antigen receptor phenotypes TCR alpha beta + and TCR gamma delta + to human immunodeficiency virus infection: a mechanism for CD4+ (T4) lymphocyte depletion.

Author

Schnittman, S M, primary, Denning, S M, additional, Greenhouse, J J, additional, Justement, J S, additional, Baseler, M, additional, Kurtzberg, J, additional, Haynes, B F, additional, and Fauci, A S, additional

Published
1990
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44. Human thymic epithelial cells directly induce activation of autologous immature thymocytes.

Author

Denning, S M, Kurtzberg, J, Le, P T, Tuck, D T, Singer, K H, and Haynes, B F

Abstract

To study the role that epithelial cells of the thymic microenvironment play in promoting activation of immature CD7+, CD2+, CD4-, CD8- (double-negative) human thymocytes, we have isolated thymocyte subsets from normal postnatal thymus and have cocultured autologous double-negative thymocytes with pure populations of thymic epithelial (TE) cells. We report that TE cells directly activate double-negative thymocytes to proliferate and that TE cells enhance the ability of double-negative thymocytes to proliferate in response to stimulation with exogenous interleukin 2. Activated double-negative thymocytes that proliferated in vitro in the presence of TE cells and interleukin 2 remained double-negative after 23 days in culture. Moreover, TE-cell culture supernatants in the absence of intact TE cells contain interleukin 1, interleukin 3, and granulocyte/macrophage-colony-stimulating factor activity for human bone marrow cells and can activate double-negative thymocytes to proliferate. Antibodies against interleukin 1 and against granulocyte/macrophage-colony-stimulating factor inhibited TE-cell-induced thymocyte activation. These data indicate that one role of TE cells in vivo may be to activate double-negative thymocytes to proliferate.

Published
1988
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45. Immature human thymocytes can be driven to differentiate into nonlymphoid lineages by cytokines from thymic epithelial cells.

Author

Kurtzberg, J, Denning, S M, Nycum, L M, Singer, K H, and Haynes, B F

Abstract

The signals and cellular interactions required for hematopoietic stem-cell commitment to the T lineage are unknown, yet are central to understanding the early stages of normal T-cell development. To study the differentiative capacity of T-cell precursors, we isolated CD4-, CD8-, surface(s) CD3- thymocytes from postnatal human thymuses and determined their capacity to differentiate into lymphoid and nonlymphoid lineages in vitro. We found that CD4-, CD8-, sCD3- thymocytes, which differentiated in the presence of T-cell conditioned medium plus interleukin 2 into T cells expressing the gamma delta receptor for antigen, were capable of differentiating into myeloid or erythroid lineages in the presence of either 5637 bladder carcinoma cell line conditioned medium plus recombinant human erythropoietin or human thymic epithelial cell conditioned medium. Thymic epithelial cell conditioned medium was as effective as 5637 supernatant plus erythropoietin in inducing myeloerythroid differentiation in the CD4-, CD8-, sCD3- thymocytes. Sixty-eight +/- 14% of CD4-, CD8-, sCD3- thymocytes underwent nonlymphoid differentiation within 4 days in culture with 5637 supernatant plus erythropoietin. Twenty-six +/- 4% of freshly isolated CD4-, CD8-, sCD3- cells were CD34+, and clonal granulocyte/macrophage, granulocyte/erythrocyte/monocyte/megakaryocyte, and T-cell progenitors were found in both CD34+ and CD34- subsets of CD4-, CD8-, sCD3- thymocytes. Thus, cells within the human CD4-, CD8-, sCD3- thymocyte subset can give rise to gamma delta+ T cells as well as to cells of myeloerythroid lineages. Moreover, CD34+, CD4-, CD8-, sCD3- cells can give rise to clonal T-cell progenitors as well as to clonal myeloid progenitors.

Published
1989
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46. The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif.

Author

Begley, C G, Aplan, P D, Denning, S M, Haynes, B F, Waldmann, T A, and Kirsch, I R

Abstract

We have identified the human gene, SCL. We discovered this gene because of its involvement in a chromosomal translocation associated with the occurrence of a stem cell leukemia manifesting myeloid and lymphoid differentiation capabilities. Here we report the sequence of a cDNA for the normal SCL transcript, as well as for an aberrant fusion transcript produced in the leukemic cells. Although different at their 3' untranslated regions, both cDNAs predict a protein with primary amino acid sequence homology to the previously described amphipathic helix-loop-helix DNA binding and dimerization motif of the Ly1-1, myc, MyoD, immunoglobulin enhancer binding, daughterless, and achaete-scute families of genes. For these cDNAs, at least two different 5' ends are predicted, both of which retain this putative DNA binding domain and predict proteins in the range of 20-30 kDa. SCL mRNA is observed in "early" hematopoietic tissues. Taken together, these studies lead to the speculation that SCL plays a role in differentiation and/or commitment events during hematopoiesis.

Published
1989
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47. Human thymocytes bind to autologous and allogeneic thymic epithelial cells in vitro.

Author

Singer, K H, Wolf, L S, Lobach, D F, Denning, S M, Tuck, D T, Robertson, A L, and Haynes, B F

Abstract

The thymus plays a critical role in the generation of immunocompetent T lymphocytes. In the thymus, lymphocytes are in close contact with epithelial cells, and this contact is necessary for T-cell maturation. Using cultured human thymic epithelial (TE) cells, we have found that human thymocytes bind to human TE cells in vitro. Thymocytes bound to both allogeneic and autologous TE cells and to the epidermoid carcinoma cell line A431 but did not bind to epidermal keratinocytes or to thymic fibroblasts. Thymocyte binding to TE cells was trypsin- and cytochalasin B-sensitive. Indirect immunofluorescence assays showed that both mature (T6-, T3+) and immature (T6+, T3-) thymocytes bound TE cells. In our system, TE-thymocyte binding was not inhibited by antibodies to class I or class II major histocompatibility antigens. In vitro binding of thymocytes to TE cells may represent a correlate of in vivo TE-thymocyte interactions and provides a model system for the study of human intrathymic T-lymphocyte maturation and activation.

Published
1986
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48. A novel activation pathway for mature thymocytes. Costimulation of CD2 (T,p50) and CD28 (T,p44) induces autocrine interleukin 2/interleukin 2 receptor-mediated cell proliferation.

Author

Yang, S Y, Denning, S M, Mizuno, S, Dupont, B, and Haynes, B F

Abstract

Prior studies have shown that thymocytes, unlike peripheral T cells, do not proliferate in response to mitogenic combinations of anti-CD2 mAbs. The present study demonstrated that stimulation by a mitogenic anti-CD2 combination (9-1 plus 9.6) with anti-CD28 induced vigorous thymocyte proliferation in the absence of exogenous IL-2. This thymocyte proliferation was IL-2 dependent as shown by the complete inhibition using anti-IL-2-R mAbs. Induction of IL-2-R transcripts was detected in thymocytes stimulated by the anti-CD2 antibody combination alone or the anti-CD2 combination plus anti-CD28 antibody. However, induction of IL-2 transcripts was observed only in thymocytes triggered jointly by the anti-CD2 combination plus anti-CD28 antibodies. The double-negative (CD4-8-) or CD1+ thymocytes isolated by sorting or by panning were unresponsive to CD2/CD28 triggering. The same mitogenic signal could induce vigorous proliferation of thymocytes with a mature phenotype, i.e., CD3+CD4+ or CD3+CD8+ thymocytes. Immunofluorescence studies demonstrated that the majority of CD3+ thymocytes were CD28+, and most of the CD28+ cells were located in the medullary compartment of thymus. These results indicated that the T cell lineage surface molecules CD28 and CD2 are involved in the regulation of expansion and further differentiation of mature thymocytes.

Published
1988
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49. EPA reporting systems: design in-house for high-quality data

Author

Powell, Denning S. and Gastler, John H.

Subjects
United States. Environmental Protection Agency, Electric power-plants -- Environmental aspects, Government paperwork -- Methods, Business, Engineering and manufacturing industries
Published
1984

50. Enhancement of Research and Development Output Utilization Efficiencies. Linker Concept Methodology in the Technology Transfer Process

Author

NAVAL POSTGRADUATE SCHOOL MONTEREY CA, Creighton, J. W., Jolly, J. A., Denning, S. A., NAVAL POSTGRADUATE SCHOOL MONTEREY CA, Creighton, J. W., Jolly, J. A., and Denning, S. A.

Abstract

It was hypothesized that there is a relationship between the output efficiency utilization of research and development and the behavioral characteristics of the individuals in the user organization. Concepts and models are discussed leading to this hypothesis. A linker type of performance is defined and a methodology for identifying such an individual is formed into a measuring instrument. Results from using the instrument in a census situation are presented. The instrument discrimination is subjected to validity tests and the results are reported.

Published
1972

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