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6. Chrysin-Induced Regression of Angiogenesis via an Induction of DNA Damage Response and Oxidative Stress in In Vitro and In Vivo Models of Melanoma

Author

Sassi, Aicha, primary, Fredon, Maxime, additional, Cotte, Alexia K., additional, Fuselier, Camille, additional, Schneider, Christophe, additional, Martiny, Laurent, additional, Monchaud, David, additional, Chekir-Ghedira, Leila, additional, Aires, Virginie, additional, and Delmas, Dominique, additional

Published
2023
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7. Carob leaf polyphenols trigger intrinsic apoptotic pathway and induce cell cycle arrest in colon cancer cells

Author

Ghanemi, Fatima Zahra, Belarbi, Meriem, Fluckiger, Aurélie, Nani, Abdelhafid, Dumont, Adélie, De Rosny, Charlotte, Aboura, Ikram, Khan, Amira Sayed, Murtaza, Babar, Benammar, Chahid, Lahfa, Boucif Farid, Patoli, Danish, Delmas, Dominique, Rébé, Cédric, Apétoh, Lionel, Khan, Naim Akhtar, Ghringhelli, François, Rialland, Mickael, and Hichami, Aziz

Published
2017
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12. Supplementary Table 2: Human primer sequences used for RT-qPCR analysis from Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX–Bevacizumab Drug Treatment Regimen

Author

Limagne, Emeric, primary, Euvrard, Romain, primary, Thibaudin, Marion, primary, Rébé, Cédric, primary, Derangère, Valentin, primary, Chevriaux, Angélique, primary, Boidot, Romain, primary, Végran, Frédérique, primary, Bonnefoy, Nathalie, primary, Vincent, Julie, primary, Bengrine-Lefevre, Leila, primary, Ladoire, Sylvain, primary, Delmas, Dominique, primary, Apetoh, Lionel, primary, and Ghiringhelli, François, primary

Published
2023
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13. Supplementary Figure 6: mRNA relative expression of genes involved in immunosuppression from Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX–Bevacizumab Drug Treatment Regimen

Author

Limagne, Emeric, primary, Euvrard, Romain, primary, Thibaudin, Marion, primary, Rébé, Cédric, primary, Derangère, Valentin, primary, Chevriaux, Angélique, primary, Boidot, Romain, primary, Végran, Frédérique, primary, Bonnefoy, Nathalie, primary, Vincent, Julie, primary, Bengrine-Lefevre, Leila, primary, Ladoire, Sylvain, primary, Delmas, Dominique, primary, Apetoh, Lionel, primary, and Ghiringhelli, François, primary

Published
2023
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14. Supplementary Figure 4: IFN-γ and IL-17A secretion by CCR6 and CXCR3 expressing CD4 T cells from Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX–Bevacizumab Drug Treatment Regimen

Author

Limagne, Emeric, primary, Euvrard, Romain, primary, Thibaudin, Marion, primary, Rébé, Cédric, primary, Derangère, Valentin, primary, Chevriaux, Angélique, primary, Boidot, Romain, primary, Végran, Frédérique, primary, Bonnefoy, Nathalie, primary, Vincent, Julie, primary, Bengrine-Lefevre, Leila, primary, Ladoire, Sylvain, primary, Delmas, Dominique, primary, Apetoh, Lionel, primary, and Ghiringhelli, François, primary

Published
2023
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15. Supplementary Figure Legends from Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX–Bevacizumab Drug Treatment Regimen

Author

Limagne, Emeric, primary, Euvrard, Romain, primary, Thibaudin, Marion, primary, Rébé, Cédric, primary, Derangère, Valentin, primary, Chevriaux, Angélique, primary, Boidot, Romain, primary, Végran, Frédérique, primary, Bonnefoy, Nathalie, primary, Vincent, Julie, primary, Bengrine-Lefevre, Leila, primary, Ladoire, Sylvain, primary, Delmas, Dominique, primary, Apetoh, Lionel, primary, and Ghiringhelli, François, primary

Published
2023
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16. Data from Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX–Bevacizumab Drug Treatment Regimen

Author

Limagne, Emeric, primary, Euvrard, Romain, primary, Thibaudin, Marion, primary, Rébé, Cédric, primary, Derangère, Valentin, primary, Chevriaux, Angélique, primary, Boidot, Romain, primary, Végran, Frédérique, primary, Bonnefoy, Nathalie, primary, Vincent, Julie, primary, Bengrine-Lefevre, Leila, primary, Ladoire, Sylvain, primary, Delmas, Dominique, primary, Apetoh, Lionel, primary, and Ghiringhelli, François, primary

Published
2023
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17. Supplementary Figure 2: MDSC gating strategy and IL-4Rα expression analysis. from Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX–Bevacizumab Drug Treatment Regimen

Author

Limagne, Emeric, primary, Euvrard, Romain, primary, Thibaudin, Marion, primary, Rébé, Cédric, primary, Derangère, Valentin, primary, Chevriaux, Angélique, primary, Boidot, Romain, primary, Végran, Frédérique, primary, Bonnefoy, Nathalie, primary, Vincent, Julie, primary, Bengrine-Lefevre, Leila, primary, Ladoire, Sylvain, primary, Delmas, Dominique, primary, Apetoh, Lionel, primary, and Ghiringhelli, François, primary

Published
2023
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18. Supplementary Figure 3: Blood parameters in Healthy Volunteers versus mCRC patients from Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX–Bevacizumab Drug Treatment Regimen

Author

Limagne, Emeric, primary, Euvrard, Romain, primary, Thibaudin, Marion, primary, Rébé, Cédric, primary, Derangère, Valentin, primary, Chevriaux, Angélique, primary, Boidot, Romain, primary, Végran, Frédérique, primary, Bonnefoy, Nathalie, primary, Vincent, Julie, primary, Bengrine-Lefevre, Leila, primary, Ladoire, Sylvain, primary, Delmas, Dominique, primary, Apetoh, Lionel, primary, and Ghiringhelli, François, primary

Published
2023
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19. Supplementary Figure 1: THelper gating strategy from Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX–Bevacizumab Drug Treatment Regimen

Author

Limagne, Emeric, primary, Euvrard, Romain, primary, Thibaudin, Marion, primary, Rébé, Cédric, primary, Derangère, Valentin, primary, Chevriaux, Angélique, primary, Boidot, Romain, primary, Végran, Frédérique, primary, Bonnefoy, Nathalie, primary, Vincent, Julie, primary, Bengrine-Lefevre, Leila, primary, Ladoire, Sylvain, primary, Delmas, Dominique, primary, Apetoh, Lionel, primary, and Ghiringhelli, François, primary

Published
2023
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20. Supplementary Table 1: Patient and Healthy volunteer's characteristics from Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX–Bevacizumab Drug Treatment Regimen

Author

Limagne, Emeric, primary, Euvrard, Romain, primary, Thibaudin, Marion, primary, Rébé, Cédric, primary, Derangère, Valentin, primary, Chevriaux, Angélique, primary, Boidot, Romain, primary, Végran, Frédérique, primary, Bonnefoy, Nathalie, primary, Vincent, Julie, primary, Bengrine-Lefevre, Leila, primary, Ladoire, Sylvain, primary, Delmas, Dominique, primary, Apetoh, Lionel, primary, and Ghiringhelli, François, primary

Published
2023
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21. Supplementary Figure 5: Blood parameters in mCRC patients, D0 versus D15 from Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX–Bevacizumab Drug Treatment Regimen

Author

Limagne, Emeric, primary, Euvrard, Romain, primary, Thibaudin, Marion, primary, Rébé, Cédric, primary, Derangère, Valentin, primary, Chevriaux, Angélique, primary, Boidot, Romain, primary, Végran, Frédérique, primary, Bonnefoy, Nathalie, primary, Vincent, Julie, primary, Bengrine-Lefevre, Leila, primary, Ladoire, Sylvain, primary, Delmas, Dominique, primary, Apetoh, Lionel, primary, and Ghiringhelli, François, primary

Published
2023
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28. Membres du comité d'organisation scientifique

Author

Adrian, Marielle, Bauer, Florian, Celito, Crivellaro, Gougeon, Régis D., Jeandet, Philippe, Moreno-Arribas, M. Victoria, Pasinetti, Giulio, Gavin, Sacks, Taillandier, Patricia, Alexandre, Hervé, Bely, Marina, Delmas, Dominique, Herderich, Markus, Jacquet, O., Marchand, Stéphanie, Parr, Wendy V., Schmitt-Kopplin, Philippe, da Silva Ferreira, António-César, Ugliano, Maurizio, Ballester, Jordi, Smith, Barry C., Fourcade, Marion, Humbert, Florian, López Plantey, Rodrigo, Rienth, Markus, Rousseaux, Sandrine, Cédric Saucier,, Maguire, Jennifer Smith, and EL Mjiyad, Noureddine

Subjects
[SDV] Life Sciences [q-bio]
Published
2022

34. Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3)

Author

Nury, Thomas, Zarrouk, Amira, Mackrill, John J., Samadi, Mohammad, Durand, Philippe, Riedinger, Jean-Marc, Doria, Margaux, Vejux, Anne, Limagne, Emeric, Delmas, Dominique, Prost, Michel, Moreau, Thibault, Hammami, Mohamed, Delage-Mourroux, Régis, OʼBrien, Nora M., and Lizard, Gérard

Published
2015
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36. An Oral FMT Capsule as Efficient as an Enema for Microbiota Reconstruction Following Disruption by Antibiotics, as Assessed in an In Vitro Human Gut Model

Author

Verdier Cécile, Denis Sylvain, Gasc Cyrielle, Boucinha Lilia, Uriot Ophélie, Delmas Dominique, Dore Joël, Le Camus Corentin, Schwintner Carole, Stephanie Blanquet-Doit, Microbiologie Environnement Digestif Santé (MEDIS), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), MaaT Pharma [Lyon], MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Maat Pharma company

Subjects
FMT, in vitro gut model, lcsh:Biology (General), gut microbiota, antibiotic, [SDV]Life Sciences [q-bio], enema, dysbiosis, oral capsule, lcsh:QH301-705.5, Article, 3. Good health
Abstract

Background Fecal microbiota transfer (FMT) is an innovative treatment already successfully used in recurrent Clostridioides difficile infections. Researchers and clinicians are exploring its potential for treating other digestive or extra-intestinal pathologies where gut microbial dysbiosis has been evidenced, such as inflammatory bowel disease, obesity or cancers. Oral capsules were recently developed to address gaps of traditional routes of FMT such as enema or colonoscopy. Clinical studies are obviously the gold standard to evaluate FMT efficiency but remain limited by regulatory, ethics and cost constraints. The aim of the study was to use the in vitro human Artificial Colon ARCOL to compare the efficiency of two enema dosage (10 and 30 g) and a new oral caecum-release capsule in restoring gut microbiota composition and activity after treatment with ciprofloxacin, an antibiotic used in leukemia patients. Results By integrating the main physicochemical parameters of the human colon (pH, retention time, nutrient supply and anaerobiosis), ARCOL was shown to capture microbial diversity and inter-individual variability of stools from three healthy donors. Treatment with ciprofloxacin led to a state of marked dysbiosis with a sharp decrease in fermentation activities (production of gases and short chain fatty acids), a loss of microbial diversity and a shift in bacterial populations. All FMT treatments were able to speed-up the restoration of microbial profiles and functions, by decreasing the number of dysbiotic days from 12 to 7–8 depending on the FMT modes. Of note, the bacterial load showed no major influence on enema performance, and oral capsule was almost as efficient as enema even if the amount of administered bacteria was 100 times lower. Conclusions This study provides the first example of using an in vitro human colon model for evaluating autologous FMT efficiency and highlights the potential of oral capsule compared to a traditional enema formulation. This new mode of FMT administration combines efficiency with convenient and minimally invasive mode of administration. In accordance to 3R rules, gut models like ARCOL can be advantageously used to test FMT in preclinical phases as an alternative to in vivo assays.

Published
2021

39. Essential Oils, Pituranthos chloranthus and Teucrium ramosissimum, Chemosensitize Resistant Human Uterine Sarcoma MES-SA/Dx5 Cells to Doxorubicin by Inducing Apoptosis and Targeting P-Glycoprotein

Author

Lahmar, Aida, primary, Mathey, Aline, additional, Aires, Virginie, additional, Elgueder, Dorra, additional, Vejux, Anne, additional, Khlifi, Rihab, additional, Sioud, Fairouz, additional, Chekir-Ghedira, Leila, additional, and Delmas, Dominique, additional

Published
2021
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40. Interaction of dietary polyphenols and gut microbiota: Microbial metabolism of polyphenols, influence on the gut microbiota, and implications on host health

Author

Catalkaya, Gizem, Venema, Koen, Lucini, Luigi, Rocchetti, Gabriele, Delmas, Dominique, Daglia, Maria, De Filippis, Anna, Xiao, Hang, Quiles, José L., Xiao, Jianbo, Capanoglu, Esra, Lucini, Luigi (ORCID:0000-0002-5133-9464), Rocchetti, Gabriele (ORCID:0000-0003-3488-4513), Catalkaya, Gizem, Venema, Koen, Lucini, Luigi, Rocchetti, Gabriele, Delmas, Dominique, Daglia, Maria, De Filippis, Anna, Xiao, Hang, Quiles, José L., Xiao, Jianbo, Capanoglu, Esra, Lucini, Luigi (ORCID:0000-0002-5133-9464), and Rocchetti, Gabriele (ORCID:0000-0003-3488-4513)

Abstract

The human gastrointestinal tract is inhabited by a vast number ofmicroorganisms that are called as the microbiota. Each individual harbors a unique gut microbial composition, this composition evolves throughout the host’s lifetime and it is easily affected by internal or external changes. It has been shown that gut microbiota plays a crucial role in host’s health and as this complex community has the ability to interact with each other and with the host’s immune system, the presence or absence of some major species can affect the homeostasis. Diet can be considered as one of the pivotal factors in modulating the functionality, integrity, and composition of the gut microbiota as the gastrointestinal tract is the first organ exposed to components of the diet. In this review,we have focused on the effects of polyphenols, key compounds of a healthy diet with several biological activities, on the gut microbial composition, their biotransformation by the gut microbiota, and the effect of their reciprocal interactions in human health and disease.

Published
2020

43. Litchi (Litchi chinensis Sonn.): a comprehensive review of phytochemistry, medicinal properties, and product development

Author

Yao, Peifen, primary, Gao, Yan, additional, Simal-Gandara, Jesus, additional, Farag, Mohamed A., additional, Chen, Weijie, additional, Yao, Dongning, additional, Delmas, Dominique, additional, Chen, Zhejie, additional, Liu, Kunmeng, additional, Hu, Hao, additional, Xiao, Jianbo, additional, Rong, Xianglu, additional, Wang, Shengpeng, additional, Hu, Yuanjia, additional, and Wang, Yitao, additional

Published
2021
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48. Resveratrol against Major Pathologies

Author

Latruffe, Norbert, primary, Delmas, Dominique, additional, Lizard, Gérard, additional, Tringali, Corrado, additional, Spatafora, Carmela, additional, Vervandier-Fasseur, Dominique, additional, and Meunier, Philippe, additional

Published
2011
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