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4. Serous cystic neoplasm of the pancreas: a multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas)

Author

Jais, B, Rebours, V, Malleo, G, Salvia, R, Fontana, M, Maggino, L, Bassi, C, Manfredi, R, Moran, R, Lennon, A M, Zaheer, A, Wolfgang, C, Hruban, R, Marchegiani, G, Fernández Del Castillo, C, Brugge, W, Ha, Y, Kim, M H, Oh, D, Hirai, I, Kimura, W, Jang, J Y, Kim, S W, Jung, W, Kang, H, Song, S Y, Kang, C M, Lee, W J, Crippa, S, Falconi, M, Gomatos, I, Neoptolemos, J, Milanetto, A C, Sperti, C, Ricci, C, Casadei, R, Bissolati, M, Balzano, G, Frigerio, I, Girelli, R, Delhaye, M, Bernier, B, Wang, H, Jang, K T, Song, D H, Huggett, M T, Oppong, K W, Pererva, L, Kopchak, K V, Del Chiaro, M, Segersvard, R, Lee, L S, Conwell, D, Osvaldt, A, Campos, V, Aguero Garcete, G, Napoleon, B, Matsumoto, I, Shinzeki, M, Bolado, F, Fernandez, J M Urman, Keane, M G, Pereira, S P, Acuna, I Araujo, Vaquero, E C, Angiolini, M R, Zerbi, A, Tang, J, Leong, R W, Faccinetto, A, Morana, G, Petrone, M C, Arcidiacono, P G, Moon, J H, Choi, H J, Gill, R S, Pavey, D, Ouaïssi, M, Sastre, B, Spandre, M, De Angelis, C G, Rios-Vives, M A, Concepcion-Martin, M, Ikeura, T, Okazaki, K, Frulloni, L, Messina, O, and Lévy, P

Published
2016
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5. Development of a Microfluidic Cyst Fluid Assay to Identify Pancreatic Cystic Neoplasms that Require Surgical Resection

Author

Pollini, T., primary, Kone, L., additional, Brugge, W., additional, Fernandez-del Castillo, C., additional, Winter, J., additional, Yeo, C., additional, Hackert, T., additional, Buechler, M., additional, Roggin, K., additional, Schmidt, C.M., additional, Yip-Schneider, M., additional, Salvia, R., additional, Bassi, C., additional, Chlipala, G., additional, and Maker, A., additional

Published
2022
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8. Evolving trends in pancreatic cystic tumors: a 3-decade single-center experience with 1290 resections

Author

Roldan, J., primary, Harrison, J., additional, Qadan, M., additional, Bolm, L., additional, Baba, T., additional, Brugge, W., additional, Casey, B., additional, Krishnan, K., additional, Mino-Kenudson, M., additional, Pitman, M., additional, Kambadakone, A., additional, Ferrone, C., additional, Warshaw, A., additional, Lillemoe, K., additional, and Castillo, C Fernandez-del, additional

Published
2021
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9. A novel microfluidic-based assay to determine high-risk pancreatic cysts for surgery utilizing pancreatic cyst fluid: an international multicenter study

Author

Kone, L., primary, Pollini, T., additional, Brugge, W., additional, Castillo, C Fernandez-del, additional, Winter, J., additional, Yeo, C.J., additional, Hackert, T., additional, Buchler, M.W., additional, Roggin, K., additional, Schmidt, C.M., additional, Yip-Schnieder, M., additional, Salvia, R., additional, Bassi, C., additional, Chlipala, G., additional, and Maker, A.V., additional

Published
2021
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12. Pseudoephedrine-induced Ventricular Tachycardia

Author

Yang, J., Wang, D., Jin, Z., Pai, M., Zhang, X., Brugge, W. R., Habib, N., Kahaleh, M., Reddy, D. N., Lakhtakia, S., Senturk, H., and KAZANCIOĞLU, Rümeyza

Subjects
medicine.medical_specialty, Side effect, Lidocaine, business.industry, medicine.medical_treatment, General Medicine, Emergency department, medicine.disease, Cardioversion, Pseudoephedrine, Ventricular tachycardia, Diabetes mellitus, Anesthesia, Internal medicine, cardiovascular system, medicine, Cardiology, Sinus rhythm, Tahmaz M., Kumbasar B., Ozturk S., KAZANCIOĞLU R., -Pseudoephedrine-induced Ventricular Tachycardia-, EUROPEAN JOURNAL OF GENERAL MEDICINE, cilt.10, ss.77-80, 2013, business, medicine.drug
Abstract

Here, we report an unusual cause of ventricular tachycardia which had developed following pseudoephedrine intake. A 55 year old male patient was admitted to the emergency department with complaints of sustained palpitation. Monitorization records revealed ventricular tachycardia of 214 beats per minute. He had been suffering upper respiratory tract symptoms for the last two days. Palpitation had started an hour later following the ingestion of cold remedy drug, which included pseudoephedrine, and serious dyspnea gradually occurred. He had ischemic heart disease and peripheral arterial disease but he did not have a history of arrhythmia, any palpitation, diabetes mellitus or hypertension. Initially, lidocaine and later amiodorone infusion was administered but medical cardioversion was not successful. Sinus rhythm was provided after electrical cardioversion with 200 joule. Thereafter the patient was stable.

Published
2013
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13. Endoscopic Ultrasound-Guided Radiofrequency Ablation for Pancreatic Neoplasms

Author

Clift, A., Pai, M., Habib, N., ŞENTÜRK, HAKAN, Laktakia, S., Reddy, N., Cicinnati, V, Kaba, I, Beckebaum, S., Drymousis, P., Kahaleh, M., Malczewska, A., Zanellato, A., Brugge, W., Frilling, A., and ŞENTÜRK, HAKAN

Subjects
Clift A., Pai M., Habib N., ŞENTÜRK H., Laktakia S., Reddy N., Cicinnati V., Kaba I., Beckebaum S., Drymousis P., et al., -Endoscopic Ultrasound-Guided Radiofrequency Ablation for Pancreatic Neoplasms-, 13th Annual ENETS Conference for the Diagnosis and Treatment of Neuroendocrine Tumor Disease, Barcelona, İspanya, 9 - 11 Mart 2016, cilt.103, ss.91
Published
2016

15. Ultrasound-mediated gastrointestinal drug delivery

Author

Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Department of Chemical Engineering, Massachusetts Institute of Technology. Department of Mechanical Engineering, Koch Institute for Integrative Cancer Research at MIT, Schoellhammer, Carl Magnus, Swiston Jr, Albert J., Zervas, Michael J., Traverso, Carlo Giovanni, Anderson, Daniel Griffith, Blankschtein, Edmundo D, Langer, Robert S, Maa, Ruby C., Schroeder, Avraham Dror, Barman, Ross, DiCiccio, Angela M, Brugge, W. R., Lauwers, Gregory Yves, Swiston, Albert J., Jr., Blankschtein, Daniel, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Department of Chemical Engineering, Massachusetts Institute of Technology. Department of Mechanical Engineering, Koch Institute for Integrative Cancer Research at MIT, Schoellhammer, Carl Magnus, Swiston Jr, Albert J., Zervas, Michael J., Traverso, Carlo Giovanni, Anderson, Daniel Griffith, Blankschtein, Edmundo D, Langer, Robert S, Maa, Ruby C., Schroeder, Avraham Dror, Barman, Ross, DiCiccio, Angela M, Brugge, W. R., Lauwers, Gregory Yves, Swiston, Albert J., Jr., and Blankschtein, Daniel

Abstract

available in PMC 2016 April 08, There is a significant clinical need for rapid and efficient delivery of drugs directly to the site of diseased tissues for the treatment of gastrointestinal (GI) pathologies, in particular, Crohn’s and ulcerative colitis. However, complex therapeutic molecules cannot easily be delivered through the GI tract because of physiologic and structural barriers. We report the use of ultrasound as a modality for enhanced drug delivery to the GI tract, with an emphasis on rectal delivery. Ultrasound increased the absorption of model therapeutics inulin, hydrocortisone, and mesalamine two- to tenfold in ex vivo tissue, depending on location in the GI tract. In pigs, ultrasound induced transient cavitation with negligible heating, leading to an order of magnitude enhancement in the delivery of mesalamine, as well as successful systemic delivery of a macromolecule, insulin, with the expected hypoglycemic response. In a rodent model of chemically induced acute colitis, the addition of ultrasound to a daily mesalamine enema (compared to enema alone) resulted in superior clinical and histological scores of disease activity. In both animal models, ultrasound treatment was well tolerated and resulted in minimal tissue disruption, and in mice, there was no significant effect on histology, fecal score, or tissue inflammatory cytokine levels. The use of ultrasound to enhance GI drug delivery is safe in animals and could augment the efficacy of GI therapies and broaden the scope of agents that could be delivered locally and systemically through the GI tract for chronic conditions such as inflammatory bowel disease., United States. National Institutes of Health (EB-00351), United States. National Institutes of Health (EB-000244), United States. National Institutes of Health (CA014051), United States. National Institutes of Health (T32-DK007191-38-S1)

Published
2017

16. Serous cystic neoplasm of the pancreas: A multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas)

Author

Jais, B., Rebours, V., Malleo, G., Salvia, R., Fontana, Tecla Maria, Maggino, L., Bassi, C., Manfredi, Riccardo, Moran, R., Lennon, A. M., Zaheer, A., Wolfgang, C., Hruban, R., Marchegiani, G., Fernandez Del Castillo, C., Brugge, W., Ha, Y., Kim, M. H., Oh, D., Hirai, I., Kimura, W., Jang, J. Y., Kim, S. W., Jung, W., Kang, H., Song, S. Y., Kang, C. M., Lee, W. J., Crippa, S., Falconi, M., Gomatos, I., Neoptolemos, J., Milanetto, A. C., Sperti, C., Ricci, C., Casadei, R., Bissolati, M., Balzano, G., Frigerio, I., Girelli, R., Delhaye, M., Bernier, B., Wang, H., Jang, K. T., Song, D. H., Huggett, M. T., Oppong, K. W., Pererva, L., Kopchak, K. V., Del Chiaro, M., Segersvard, R., Lee, L. S., Conwell, D., Osvaldt, A., Campos, V., Aguero Garcete, G., Napoleon, B., Matsumoto, I., Shinzeki, M., Bolado, F., Urman Fernandez, J. M., Keane, M. G., Pereira, S. P., Araujo Acuna, I., Vaquero, E. C., Angiolini, M. R., Zerbi, A., Tang, J., Leong, R. W., Faccinetto, A., Morana, G., Petrone, M. C., Arcidiacono, P. G., Moon, J. H., Choi, H. J., Gill, R. S., Pavey, D., Ouaissi, M., Sastre, B., Spandre, M., De Angelis, C. G., Rios-Vives, M. A., Concepcion-Martin, M., Ikeura, T., Okazaki, K., Frulloni, L., Messina, O., Levy, P., Fontana M., Manfredi R. (ORCID:0000-0002-4972-9500), Jais, B., Rebours, V., Malleo, G., Salvia, R., Fontana, Tecla Maria, Maggino, L., Bassi, C., Manfredi, Riccardo, Moran, R., Lennon, A. M., Zaheer, A., Wolfgang, C., Hruban, R., Marchegiani, G., Fernandez Del Castillo, C., Brugge, W., Ha, Y., Kim, M. H., Oh, D., Hirai, I., Kimura, W., Jang, J. Y., Kim, S. W., Jung, W., Kang, H., Song, S. Y., Kang, C. M., Lee, W. J., Crippa, S., Falconi, M., Gomatos, I., Neoptolemos, J., Milanetto, A. C., Sperti, C., Ricci, C., Casadei, R., Bissolati, M., Balzano, G., Frigerio, I., Girelli, R., Delhaye, M., Bernier, B., Wang, H., Jang, K. T., Song, D. H., Huggett, M. T., Oppong, K. W., Pererva, L., Kopchak, K. V., Del Chiaro, M., Segersvard, R., Lee, L. S., Conwell, D., Osvaldt, A., Campos, V., Aguero Garcete, G., Napoleon, B., Matsumoto, I., Shinzeki, M., Bolado, F., Urman Fernandez, J. M., Keane, M. G., Pereira, S. P., Araujo Acuna, I., Vaquero, E. C., Angiolini, M. R., Zerbi, A., Tang, J., Leong, R. W., Faccinetto, A., Morana, G., Petrone, M. C., Arcidiacono, P. G., Moon, J. H., Choi, H. J., Gill, R. S., Pavey, D., Ouaissi, M., Sastre, B., Spandre, M., De Angelis, C. G., Rios-Vives, M. A., Concepcion-Martin, M., Ikeura, T., Okazaki, K., Frulloni, L., Messina, O., Levy, P., Fontana M., and Manfredi R. (ORCID:0000-0002-4972-9500)

Abstract

Objectives Serous cystic neoplasm (SCN) is a cystic neoplasm of the pancreas whose natural history is poorly known. The purpose of the study was to attempt to describe the natural history of SCN, including the specific mortality. Design Retrospective multinational study including SCN diagnosed between 1990 and 2014. Results 2622 patients were included. Seventy-four per cent were women, and median age at diagnosis was 58 years (16-99). Patients presented with non-specific abdominal pain (27%), pancreaticobiliary symptoms (9%), diabetes mellitus (5%), other symptoms (4%) and/or were asymptomatic (61%). Fifty-two per cent of patients were operated on during the first year after diagnosis (median size: 40 mm (2-200)), 9% had resection beyond 1 year of follow-up (3 years (1-20), size at diagnosis: 25 mm (4- 140)) and 39% had no surgery (3.6 years (1-23), 25.5 mm (1-200)). Surgical indications were (not exclusive) uncertain diagnosis (60%), symptoms (23%), size increase (12%), large size (6%) and adjacent organ compression (5%). In patients followed beyond 1 year (n=1271), size increased in 37% (growth rate: 4 mm/ year), was stable in 57% and decreased in 6%. Three serous cystadenocarcinomas were recorded. Postoperative mortality was 0.6% (n=10), and SCN's related mortality was 0.1% (n=1).

Published
2016

20. Serous cystic neoplasm of the pancreas: a multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas)

Author

Jais, B, primary, Rebours, V, additional, Malleo, G, additional, Salvia, R, additional, Fontana, M, additional, Maggino, L, additional, Bassi, C, additional, Manfredi, R, additional, Moran, R, additional, Lennon, A M, additional, Zaheer, A, additional, Wolfgang, C, additional, Hruban, R, additional, Marchegiani, G, additional, Fernández Del Castillo, C, additional, Brugge, W, additional, Ha, Y, additional, Kim, M H, additional, Oh, D, additional, Hirai, I, additional, Kimura, W, additional, Jang, J Y, additional, Kim, S W, additional, Jung, W, additional, Kang, H, additional, Song, S Y, additional, Kang, C M, additional, Lee, W J, additional, Crippa, S, additional, Falconi, M, additional, Gomatos, I, additional, Neoptolemos, J, additional, Milanetto, A C, additional, Sperti, C, additional, Ricci, C, additional, Casadei, R, additional, Bissolati, M, additional, Balzano, G, additional, Frigerio, I, additional, Girelli, R, additional, Delhaye, M, additional, Bernier, B, additional, Wang, H, additional, Jang, K T, additional, Song, D H, additional, Huggett, M T, additional, Oppong, K W, additional, Pererva, L, additional, Kopchak, K V, additional, Del Chiaro, M, additional, Segersvard, R, additional, Lee, L S, additional, Conwell, D, additional, Osvaldt, A, additional, Campos, V, additional, Aguero Garcete, G, additional, Napoleon, B, additional, Matsumoto, I, additional, Shinzeki, M, additional, Bolado, F, additional, Fernandez, J M Urman, additional, Keane, M G, additional, Pereira, S P, additional, Acuna, I Araujo, additional, Vaquero, E C, additional, Angiolini, M R, additional, Zerbi, A, additional, Tang, J, additional, Leong, R W, additional, Faccinetto, A, additional, Morana, G, additional, Petrone, M C, additional, Arcidiacono, P G, additional, Moon, J H, additional, Choi, H J, additional, Gill, R S, additional, Pavey, D, additional, Ouaïssi, M, additional, Sastre, B, additional, Spandre, M, additional, De Angelis, C G, additional, Rios-Vives, M A, additional, Concepcion-Martin, M, additional, Ikeura, T, additional, Okazaki, K, additional, Frulloni, L, additional, Messina, O, additional, and Lévy, P, additional

Published
2015
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21. Community Sanctions and Measures and Probation Agencies

Author

Heiskanen, M. (ed.), Aebi, M.F. (ed.), van der Brugge, W. (ed.), Jehle, J.M. (ed.), Palmowski, N., Campistol, C., Jehle, J.M., van Kalmthout, A., Heiskanen, M. (ed.), Aebi, M.F. (ed.), van der Brugge, W. (ed.), Jehle, J.M. (ed.), Palmowski, N., Campistol, C., Jehle, J.M., and van Kalmthout, A.

Published
2014

23. Endoscopic ultrasound-guided fine-needle aspiration for diagnosis of solid pseudopapillary tumors of the pancreas: a multicenter experience.

Author

Jani N, Dewitt J, Eloubeidi M, Varadarajulu S, Appalaneni V, Hoffman B, Brugge W, Lee K, Khalid A, McGrath K, Jani, N, Dewitt, J, Eloubeidi, M, Varadarajulu, S, Appalaneni, V, Hoffman, B, Brugge, W, Lee, K, Khalid, A, and McGrath, K

Abstract

Background and Study Aims: Solid pseudopapillary tumors of the pancreas are rare, low-grade, epithelial neoplasms that are usually discovered incidentally in young women. Distinguishing solid pseudopapillary tumors from other pancreatic tumors, especially pancreatic endocrine tumors, can be challenging. The role of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in this context remains unclear. The purpose of this study was to describe the endoscopic ultrasound features of solid pseudopapillary tumors and the role of EUS-FNA in the preoperative diagnosis of these tumors. Patients and Methods: Patients from five tertiary referral centers with surgically confirmed solid pseudopapillary tumors who had undergone preoperative EUS-FNA were included. The endoscopic ultrasound findings, cytologic descriptions, immunostaining results, operative records, surgical pathology, and results of the most recent clinical follow-up were reviewed. Results: A total of 28 patients were identified (four men [14 %], 24 women [86 %], mean age +/- standard deviation [SD] 35 +/- 10 years). Solid pseudopapillary tumors had been found as incidental findings on cross-sectional imaging in 50 % of cases. The mean tumor size +/- SD was 42 +/- 19.5 mm and the majority were located in the pancreatic body and tail. The endoscopic ultrasound report described a well-defined, echo-poor mass in 86 %; the tumors were solid in 14 patients (50 %), mixed solid and cystic in 11 patients (39 %), and cystic in three patients (11 %). A preoperative diagnosis of solid pseudopapillary tumor was made in 21 patients (75 %) on the basis of EUS-FNA cytology. Surgical resection was performed in all cases. Laparoscopic resection was performed in eight of these patients (29 %). Conclusions: A solid pseudopapillary tumor should be included in the differential diagnosis of any well-demarcated, echo-poor, solid or mixed solid/cystic pancreatic lesion seen during endoscopic ultrasound, particularly in young women. The diagnostic accuracy of EUS-FNA for solid pseudopapillary tumors was 75 % in this study. A definitive preoperative diagnosis can guide the surgical approach in selected cases. [ABSTRACT FROM AUTHOR]

Published
2008
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26. Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes

Author

Mino-Kenudson, M., primary, Fernandez-del Castillo, C., additional, Baba, Y., additional, Valsangkar, N. P., additional, Liss, A. S., additional, Hsu, M., additional, Correa-Gallego, C., additional, Ingkakul, T., additional, Perez Johnston, R., additional, Turner, B. G., additional, Androutsopoulos, V., additional, Deshpande, V., additional, McGrath, D., additional, Sahani, D. V., additional, Brugge, W. R., additional, Ogino, S., additional, Pitman, M. B., additional, Warshaw, A. L., additional, and Thayer, S. P., additional

Published
2011
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28. A randomized trial comparing uncovered and partially covered self- expandable metal stents in the palliation of distal malignant biliary obstruction

Author

J., Telford J, additional, L., Carr-Locke D, additional, H., Baron T, additional, M., Poneros J, additional, C., Bounds B, additional, B., Kelsey P, additional, H., Schapiro R, additional, S., Huang C, additional, R., Lichtenstein D, additional, C., Jacobson B, additional, R., Saltzman J, additional, C., Thompson C, additional, G., Forcione D, additional, J., Gostout C, additional, and R., Brugge W, additional

Published
2011
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31. INCIDENTALLY DISCOVERED PANCREATIC CYSTS

Author

Correa-Gallego, C., primary, Ferrone, C., additional, Sahani, D., additional, Forcione, D., additional, Brugge, W., additional, Thayer, S. P., additional, Warshaw, A. L., additional, and Fernandez-del Castillo, C., additional

Published
2008
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46. Pseudocyst of the pancreas: the role of cytology and special stains for mucin.

Author

Gonzalez Obeso E, Murphy E, Brugge W, Deshpande V, Gonzalez Obeso, Elvira, Murphy, Erin, Brugge, William, and Deshpande, Vikram

Abstract

Background: Currently, the preoperative diagnosis of a pancreatic cyst is based on clinical and imaging findings, frequently in conjunction with chemical analysis of cyst fluid and cytologic evaluation. The purpose of these diagnostic tests is to distinguish benign from malignant cysts of the pancreas. Accordingly, it is imperative to distinguish pancreatic pseudocysts from their mimics. In this study, the authors explored the cytomorphologic features of pseudocyst of the pancreas and evaluated the role of Alcian blue and mucicarmine stains in the cytologic evaluation of pancreatic cysts. Methods: Forty-two patients were identified who had an eventual diagnosis of pancreatic pseudocyst and had an endoscopic ultrasound-guided fine-needle aspirate available. Clinical and imaging findings and chemical analyses of cyst fluid were recorded. The cytologic preparations were evaluated for gastrointestinal contamination, inflammatory cells, mucin, and pigmented material. The cytomorphologic features of 110 neoplastic mucinous cysts (intraductal papillary-mucinous neoplasms/mucinous cystic neoplasms of the pancreas) were evaluated and compared with the pseudocysts. Results: The majority of patients (95%) had a prior episode of pancreatitis. On imaging, the pseudocysts were unilocular (92%). In 69% of cases, the endosonographic diagnosis was that of a pseudocyst. The mean carcinoembryonic antigen level was 41 ng/mL. In contrast, the cytopathologist rendered a definitive diagnosis of pseudocyst in only 10% of cases. The majority of smears (75%) revealed neutrophils and/or histiocytes. Atypical epithelial clusters were identified in 3 cases, 1 of which was diagnosed as suspicious for carcinoma. Yellow pigmented material, which was identified in 13 pseudocysts (31%), was not observed in neoplastic mucinous cysts. Alcian blue- and mucicarmine-positive material was identified in 64% and 40% of pseudocysts, respectively, and in 57% and 38% of neoplastic mucinous cysts, respectively. Conclusions: The diagnosis of a pseudocyst depended primarily on clinical and imaging findings and on chemical analysis of cyst fluid. The cytologic features frequently were nonspecific. The presence of yellow pigmented material served as a surrogate marker of a pseudocyst. Special stains for mucin did not distinguish pseudocysts from neoplastic mucinous cysts. [ABSTRACT FROM AUTHOR]

Published
2011
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50. Guidelines for credentialing and granting privileges for endoscopic ultrasound

Author

Eisen, G. M., Jason Dominitz, Faigel, D. O., Goldstein, J. A., Petersen, B. T., Raddawi, H. M., Ryan, M. E., Vargo Nd, J. J., Young, H. S., Wheeler-Harbaugh, J., Hawes, R. H., Brugge, W. R., Carrougher, J. G., Chak, A., Kochman, M. L., Savides, T. J., Wallace, M. B., Wiersema, M. J., and Erickson, R. A.

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