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13. Rapha Summer Sale - 10 of the best MTB deals you can't miss

Author

Brett, Paul

Subjects
Cycling, Company pricing policy
Abstract

Byline: Paul Brett These Rapha discounts on its off-road cycling kit have up to 50% off with final reductions just added Rapha has its Summer Sale running and the iconic [...]

Published
2024

45. Investigating the relationship between diabetes and frozen shoulder : longitudinal analysis of primary care medical records

Author

Dyer, Brett Paul and Bucknall, M.

Subjects
R Medicine (General)
Abstract

Introduction Frozen shoulder, a condition that can cause prolonged pain and disability, has previously been found to be common amongst people with diabetes. This thesis aimed to improve the understanding of the nature of the relationship between diabetes and frozen shoulder. Methods Evidence from existing longitudinal observational studies was summarised to assess whether diabetes is a risk factor for the onset of frozen shoulder, as well as whether it is a prognostic factor for poor outcomes of frozen shoulder. A series of cohort studies based on data from Clinical Practice Research Datalink (CPRD) were subsequently undertaken to establish these relationships more accurately and comprehensively, and to investigate whether the effect of diabetes on the risk of developing frozen shoulder is mediated through metabolic health. The association between newly diagnosed frozen shoulder and a subsequent diabetes diagnosis was also estimated. Results Most of the relevant studies identified in the literature search were at high risk of bias. Causal mediation analysis of 87,954 patients from CPRD suggested that diabetes does affect the development of frozen shoulder, but the effect is unlikely to be mediated by metabolic health. Following the 15.8-year follow-up, the probability for the frozen shoulder group to be diagnosed with diabetes was 5% versus 0.28% in those without frozen shoulder. Diabetes was a predictor of surgery in 40,644 patients with frozen shoulder. Conclusion Evidence suggests that diabetes is a potential cause of frozen shoulder, although our results did not support the hypothesis that metabolic health mediates the effect of diabetes on the development of frozen shoulder. People with frozen shoulder are more likely to have a subsequent diagnosis of diabetes; future research is required to determine whether testing all patients with frozen shoulder is an effective strategy to detect diabetes early in its course and reduce the likelihood of complications.

Published
2022

47. A1: A Distributed In-Memory Graph Database

Author

Buragohain, Chiranjeeb, Risvik, Knut Magne, Brett, Paul, Castro, Miguel, Cho, Wonhee, Cowhig, Joshua, Gloy, Nikolas, Kalyanaraman, Karthik, Khanna, Richendra, Pao, John, Renzelmann, Matthew, Shamis, Alex, Tan, Timothy, and Zheng, Shuheng

Subjects
Computer Science - Databases, Computer Science - Distributed, Parallel, and Cluster Computing
Abstract

A1 is an in-memory distributed database used by the Bing search engine to support complex queries over structured data. The key enablers for A1 are availability of cheap DRAM and high speed RDMA (Remote Direct Memory Access) networking in commodity hardware. A1 uses FaRM as its underlying storage layer and builds the graph abstraction and query engine on top. The combination of in-memory storage and RDMA access requires rethinking how data is allocated, organized and queried in a large distributed system. A single A1 cluster can store tens of billions of vertices and edges and support a throughput of 350+ million of vertex reads per second with end to end query latency in single digit milliseconds. In this paper we describe the A1 data model, RDMA optimized data structures and query execution.

Published
2020
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