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1. Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization.

Author

Canzian, Federico, Du, Mengmeng, Gallinger, Steven, Giles, Graham, Goodman, Phyllis, Haiman, Christopher, Kogevinas, Manolis, Kooperberg, Charles, LeMarchand, Loic, Neale, Rachel, Visvanathan, Kala, White, Emily, Albanes, Demetrius, Andreotti, Gabriella, Babic, Ana, Berndt, Sonja, Brais, Lauren, Brennan, Paul, Buring, Julie, Rabe, Kari, Bamlet, William, Chanock, Stephen, Fuchs, Charles, Gaziano, J, Giovannucci, Edward, Hackert, Thilo, Hassan, Manal, Katzke, Verena, Kurtz, Robert, Lee, I-Min, Malats, Núria, Murphy, Neil, Oberg, Ann, Orlow, Irene, Porta, Miquel, Real, Francisco, Rothman, Nathaniel, Sesso, Howard, Silverman, Debra, Thompson, Ian, Wactawski-Wende, Jean, Wang, Xiaoliang, Wentzensen, Nicolas, Yu, Herbert, Zeleniuch-Jacquotte, Anne, Yu, Kai, Wolpin, Brian, Duell, Eric, Li, Donghui, Hung, Rayjean, Perdomo, Sandra, McCullough, Marjorie, Freedman, Neal, Patel, Alpa, Peters, Ulrike, Riboli, Elio, Sund, Malin, Tjønneland, Anne, Zhong, Jun, Van Den Eeden, Stephen, Kraft, Peter, Risch, Harvey, Amundadottir, Laufey, Klein, Alison, Stolzenberg-Solomon, Rachael, Antwi, Samuel, King, Sontoria, Veliginti, Swathi, Brouwers, Martijn, Ren, Zhewen, Zheng, Wei, Setiawan, Veronica, Wilkens, Lynne, Shu, Xiao-Ou, Arslan, Alan, Beane Freeman, Laura, and Bracci, Paige

Subjects
Humans, Non-alcoholic Fatty Liver Disease, Genetic Predisposition to Disease, Genome-Wide Association Study, Mendelian Randomization Analysis, Pancreatic Neoplasms, Obesity, Polymorphism, Single Nucleotide
Abstract

BACKGROUND: There are conflicting data on whether nonalcoholic fatty liver disease (NAFLD) is associated with susceptibility to pancreatic cancer. Using Mendelian randomization (MR), we investigated the relationship between genetic predisposition to NAFLD and risk for pancreatic cancer. METHODS: Data from genome-wide association studies (GWAS) within the Pancreatic Cancer Cohort Consortium (PanScan; cases n = 5,090, controls n = 8,733) and the Pancreatic Cancer Case Control Consortium (PanC4; cases n = 4,163, controls n = 3,792) were analyzed. We used data on 68 genetic variants with four different MR methods [inverse variance weighting (IVW), MR-Egger, simple median, and penalized weighted median] separately to predict genetic heritability of NAFLD. We then assessed the relationship between each of the four MR methods and pancreatic cancer risk, using logistic regression to calculate ORs and 95% confidence intervals (CI), adjusting for PC risk factors, including obesity and diabetes. RESULTS: No association was found between genetically predicted NAFLD and pancreatic cancer risk in the PanScan or PanC4 samples [e.g., PanScan, IVW OR, 1.04; 95% confidence interval (CI), 0.88-1.22; MR-Egger OR, 0.89; 95% CI, 0.65-1.21; PanC4, IVW OR, 1.07; 95% CI, 0.90-1.27; MR-Egger OR, 0.93; 95% CI, 0.67-1.28]. None of the four MR methods indicated an association between genetically predicted NAFLD and pancreatic cancer risk in either sample. CONCLUSIONS: Genetic predisposition to NAFLD is not associated with pancreatic cancer risk. IMPACT: Given the close relationship between NAFLD and metabolic conditions, it is plausible that any association between NAFLD and pancreatic cancer might reflect host metabolic perturbations (e.g., obesity, diabetes, or metabolic syndrome) and does not necessarily reflect a causal relationship between NAFLD and pancreatic cancer.

Published
2023

2. Clinical outcomes and ctDNA correlates for CAPOX BETR: a phase II trial of capecitabine, oxaliplatin, bevacizumab, trastuzumab in previously untreated advanced HER2+ gastroesophageal adenocarcinoma

Author

Singh, Harshabad, Lowder, Kristen E., Kapner, Kevin, Kelly, Ronan J., Zheng, Hui, McCleary, Nadine Jackson, Abrams, Thomas A., Chan, Jennifer A., Regan, Eileen M., Klempner, Samuel J., Hannigan, Alison M., Remland, Joshua, Brais, Lauren K., Andrews, Elizabeth, Yurgelun, Matthew, Cleary, James M., Rubinson, Douglas A., Ritterhouse, Lauren L., Maron, Garrett, Aguirre, Andrew J., Meyerhardt, Jeffrey A., Gardecki, Emma, Lennerz, Jochen K., Wolpin, Brian M., and Enzinger, Peter C.

Published
2024
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3. Adipose tissue and skeletal muscle wasting precede clinical diagnosis of pancreatic cancer

Author

Babic, Ana, Rosenthal, Michael H., Sundaresan, Tilak K., Khalaf, Natalia, Lee, Valerie, Brais, Lauren K., Loftus, Maureen, Caplan, Leah, Denning, Sarah, Gurung, Anamol, Harrod, Joanna, Schawkat, Khoschy, Yuan, Chen, Wang, Qiao-Li, Lee, Alice A., Biller, Leah H., Yurgelun, Matthew B., Ng, Kimmie, Nowak, Jonathan A., Aguirre, Andrew J., Bhatia, Sangeeta N., Vander Heiden, Matthew G., Van Den Eeden, Stephen K., Caan, Bette J., and Wolpin, Brian M.

Published
2023
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4. Spatially organized multicellular immune hubs in human colorectal cancer.

Author

Pelka, Karin, Hofree, Matan, Chen, Jonathan, Sarkizova, Siranush, Pirl, Joshua, Jorgji, Vjola, Bejnood, Alborz, Dionne, Danielle, Ge, William, Xu, Katherine, Chao, Sherry, Zollinger, Daniel, Lieb, David, Reeves, Jason, Fuhrman, Christopher, Hoang, Margaret, Delorey, Toni, Nguyen, Lan, Waldman, Julia, Klapholz, Max, Wakiro, Isaac, Cohen, Ofir, Albers, Julian, Smillie, Christopher, Cuoco, Michael, Wu, Jingyi, Su, Mei-Ju, Yeung, Jason, Vijaykumar, Brinda, Magnuson, Angela, Asinovski, Natasha, Moll, Tabea, Goder-Reiser, Max, Applebaum, Anise, Brais, Lauren, DelloStritto, Laura, Denning, Sarah, Phillips, Susannah, Hill, Emma, Meehan, Julia, Frederick, Dennie, Sharova, Tatyana, Kanodia, Abhay, Todres, Ellen, Jané-Valbuena, Judit, Biton, Moshe, Izar, Benjamin, Lambden, Conner, Clancy, Thomas, Bleday, Ronald, Melnitchouk, Nelya, Irani, Jennifer, Kunitake, Hiroko, Berger, David, Srivastava, Amitabh, Hornick, Jason, Ogino, Shuji, Rotem, Asaf, Vigneau, Sébastien, Johnson, Bruce, Corcoran, Ryan, Sharpe, Arlene, Kuchroo, Vijay, Ng, Kimmie, Giannakis, Marios, Nieman, Linda, Boland, Genevieve, Aguirre, Andrew, Anderson, Ana, Rozenblatt-Rosen, Orit, Regev, Aviv, and Hacohen, Nir

Subjects
MSI, MSS, anti-tumor immunity, cell-cell interactions, colorectal cancer, mismatch repair-deficient, mismatch repair-proficient, scRNA-seq, spatial, tumor atlas, Bone Morphogenetic Proteins, Cancer-Associated Fibroblasts, Cell Compartmentation, Cell Line, Tumor, Chemokines, Cohort Studies, Colorectal Neoplasms, DNA Mismatch Repair, Endothelial Cells, Gene Expression Regulation, Neoplastic, Humans, Immunity, Inflammation, Monocytes, Myeloid Cells, Neutrophils, Stromal Cells, T-Lymphocytes, Transcription, Genetic
Abstract

Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To understand the rules governing these varied responses, we transcriptionally profiled 371,223 cells from colorectal tumors and adjacent normal tissues of 28 MMRp and 34 MMRd individuals. Analysis of 88 cell subsets and their 204 associated gene expression programs revealed extensive transcriptional and spatial remodeling across tumors. To discover hubs of interacting malignant and immune cells, we identified expression programs in different cell types that co-varied across tumors from affected individuals and used spatial profiling to localize coordinated programs. We discovered a myeloid cell-attracting hub at the tumor-luminal interface associated with tissue damage and an MMRd-enriched immune hub within the tumor, with activated T cells together with malignant and myeloid cells expressing T cell-attracting chemokines. By identifying interacting cellular programs, we reveal the logic underlying spatially organized immune-malignant cell networks.

Published
2021

5. A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories

Author

Placido, Davide, Yuan, Bo, Hjaltelin, Jessica X., Zheng, Chunlei, Haue, Amalie D., Chmura, Piotr J., Yuan, Chen, Kim, Jihye, Umeton, Renato, Antell, Gregory, Chowdhury, Alexander, Franz, Alexandra, Brais, Lauren, Andrews, Elizabeth, Marks, Debora S., Regev, Aviv, Ayandeh, Siamack, Brophy, Mary T., Do, Nhan V., Kraft, Peter, Wolpin, Brian M., Rosenthal, Michael H., Fillmore, Nathanael R., Brunak, Søren, and Sander, Chris

Published
2023
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6. A blood-based metabolomic signature predictive of risk for pancreatic cancer

Author

Irajizad, Ehsan, Kenney, Ana, Tang, Tiffany, Vykoukal, Jody, Wu, Ranran, Murage, Eunice, Dennison, Jennifer B., Sans, Marta, Long, James P., Loftus, Maureen, Chabot, John A., Kluger, Michael D., Kastrinos, Fay, Brais, Lauren, Babic, Ana, Jajoo, Kunal, Lee, Linda S., Clancy, Thomas E., Ng, Kimmie, Bullock, Andrea, Genkinger, Jeanine M., Maitra, Anirban, Do, Kim-Anh, Yu, Bin, Wolpin, Brian M., Hanash, Sam, and Fahrmann, Johannes F.

Published
2023
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7. Diagnostic TR-FRET assays for detection of antibodies in patient samples

Author

Yue, Hong, Nowak, Radosław P., Overwijn, Daan, Payne, N. Connor, Fischinger, Stephanie, Atyeo, Caroline, Lam, Evan C., St. Denis, Kerri, Brais, Lauren K., Konishi, Yoshinobu, Sklavenitis-Pistofidis, Romanos, Baden, Lindsey R., Nilles, Eric J., Karlson, Elizabeth W., Yu, Xu G., Li, Jonathan Z., Woolley, Ann E., Ghobrial, Irene M., Meyerhardt, Jeffrey A., Balazs, Alejandro B., Alter, Galit, Mazitschek, Ralph, and Fischer, Eric S.

Published
2023
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8. Fully-Automated Analysis of Body Composition from CT in Cancer Patients Using Convolutional Neural Networks

Author

Bridge, Christopher P., Rosenthal, Michael, Wright, Bradley, Kotecha, Gopal, Fintelmann, Florian, Troschel, Fabian, Miskin, Nityanand, Desai, Khanant, Wrobel, William, Babic, Ana, Khalaf, Natalia, Brais, Lauren, Welch, Marisa, Zellers, Caitlin, Tenenholtz, Neil, Michalski, Mark, Wolpin, Brian, and Andriole, Katherine

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

The amounts of muscle and fat in a person's body, known as body composition, are correlated with cancer risks, cancer survival, and cardiovascular risk. The current gold standard for measuring body composition requires time-consuming manual segmentation of CT images by an expert reader. In this work, we describe a two-step process to fully automate the analysis of CT body composition using a DenseNet to select the CT slice and U-Net to perform segmentation. We train and test our methods on independent cohorts. Our results show Dice scores (0.95-0.98) and correlation coefficients (R=0.99) that are favorable compared to human readers. These results suggest that fully automated body composition analysis is feasible, which could enable both clinical use and large-scale population studies.

Published
2018
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9. Highly Sensitive Circulating Tumor DNA Assay Aids Clinical Management of Radiographically Occult Isolated Peritoneal Metastases in Patients With GI Cancer

Author

Singh, Harshabad, Klempner, Samuel J., Melnitchouk, Nelya, Chander, Deepak P., Negrea, Ovidiu George, Patel, Anuj K., Schlechter, Benjamin L., Rubinson, Douglas A., Huffman, Brandon M., Nambiar, Chetan, Remland, Joshua, Andrews, Elizabeth, Leahy, Megan E., Brais, Lauren K., Enzinger, Peter C., Mamon, Harvey J., Giannakis, Marios, Meyerhardt, Jeffrey A., Ng, Kimmie, Perez, Kimberly J., Aguirre, Andrew J., Clark, Jeffrey W., Cleary, James M., and Wolpin, Brian M.

Published
2023
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10. Supplementary Figures S1-S7 from Sotorasib Is a Pan-RASG12C Inhibitor Capable of Driving Clinical Response in NRASG12C Cancers

Author

Rubinson, Douglas A., primary, Tanaka, Noritaka, primary, Fece de la Cruz, Ferran, primary, Kapner, Kevin S., primary, Rosenthal, Michael H., primary, Norden, Bryanna L., primary, Barnes, Haley, primary, Ehnstrom, Sara, primary, Morales-Giron, Alvin A., primary, Brais, Lauren K., primary, Lemke, Christopher T., primary, Aguirre, Andrew J., primary, and Corcoran, Ryan B., primary

Published
2024
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11. Data from Sotorasib Is a Pan-RASG12C Inhibitor Capable of Driving Clinical Response in NRASG12C Cancers

Author

Rubinson, Douglas A., primary, Tanaka, Noritaka, primary, Fece de la Cruz, Ferran, primary, Kapner, Kevin S., primary, Rosenthal, Michael H., primary, Norden, Bryanna L., primary, Barnes, Haley, primary, Ehnstrom, Sara, primary, Morales-Giron, Alvin A., primary, Brais, Lauren K., primary, Lemke, Christopher T., primary, Aguirre, Andrew J., primary, and Corcoran, Ryan B., primary

Published
2024
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12. Supplementary Figure 1 from RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer

Author

Singh, Harshabad, primary, Sahgal, Pranshu, primary, Kapner, Kevin, primary, Corsello, Steven M., primary, Gupta, Hersh, primary, Gujrathi, Rahul, primary, Li, Yvonne Y., primary, Cherniack, Andrew D., primary, El Alam, Raquelle, primary, Kerfoot, Joseph, primary, Andrews, Elizabeth, primary, Lee, Annette, primary, Nambiar, Chetan, primary, Hannigan, Alison M., primary, Remland, Joshua, primary, Brais, Lauren, primary, Leahy, Meghan E., primary, Rubinson, Douglas A., primary, Schlechter, Benjamin L., primary, Meyerson, Matthew, primary, Kuang, Yanan, primary, Paweletz, Cloud P., primary, Lee, Jessica K., primary, Quintanilha, Julia C.F., primary, Aguirre, Andrew J., primary, Perez, Kimberly J., primary, Huffman, Brandon M., primary, Rossi, Humberto, primary, Abrams, Thomas A., primary, Kabraji, Sheheryar, primary, Trusolino, Livio, primary, Bertotti, Andrea, primary, Sicinska, Ewa T., primary, Parikh, Aparna R., primary, Wolpin, Brian M., primary, Schrock, Alexa B., primary, Giannakis, Marios, primary, Ng, Kimmie, primary, Meyerhardt, Jeffrey A., primary, Hornick, Jason L., primary, Sethi, Nilay S., primary, and Cleary, James M., primary

Published
2024
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13. Supplementary Table 1 from RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer

Author

Singh, Harshabad, primary, Sahgal, Pranshu, primary, Kapner, Kevin, primary, Corsello, Steven M., primary, Gupta, Hersh, primary, Gujrathi, Rahul, primary, Li, Yvonne Y., primary, Cherniack, Andrew D., primary, El Alam, Raquelle, primary, Kerfoot, Joseph, primary, Andrews, Elizabeth, primary, Lee, Annette, primary, Nambiar, Chetan, primary, Hannigan, Alison M., primary, Remland, Joshua, primary, Brais, Lauren, primary, Leahy, Meghan E., primary, Rubinson, Douglas A., primary, Schlechter, Benjamin L., primary, Meyerson, Matthew, primary, Kuang, Yanan, primary, Paweletz, Cloud P., primary, Lee, Jessica K., primary, Quintanilha, Julia C.F., primary, Aguirre, Andrew J., primary, Perez, Kimberly J., primary, Huffman, Brandon M., primary, Rossi, Humberto, primary, Abrams, Thomas A., primary, Kabraji, Sheheryar, primary, Trusolino, Livio, primary, Bertotti, Andrea, primary, Sicinska, Ewa T., primary, Parikh, Aparna R., primary, Wolpin, Brian M., primary, Schrock, Alexa B., primary, Giannakis, Marios, primary, Ng, Kimmie, primary, Meyerhardt, Jeffrey A., primary, Hornick, Jason L., primary, Sethi, Nilay S., primary, and Cleary, James M., primary

Published
2024
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14. Supplementary Table 8 from RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer

Author

Singh, Harshabad, primary, Sahgal, Pranshu, primary, Kapner, Kevin, primary, Corsello, Steven M., primary, Gupta, Hersh, primary, Gujrathi, Rahul, primary, Li, Yvonne Y., primary, Cherniack, Andrew D., primary, El Alam, Raquelle, primary, Kerfoot, Joseph, primary, Andrews, Elizabeth, primary, Lee, Annette, primary, Nambiar, Chetan, primary, Hannigan, Alison M., primary, Remland, Joshua, primary, Brais, Lauren, primary, Leahy, Meghan E., primary, Rubinson, Douglas A., primary, Schlechter, Benjamin L., primary, Meyerson, Matthew, primary, Kuang, Yanan, primary, Paweletz, Cloud P., primary, Lee, Jessica K., primary, Quintanilha, Julia C.F., primary, Aguirre, Andrew J., primary, Perez, Kimberly J., primary, Huffman, Brandon M., primary, Rossi, Humberto, primary, Abrams, Thomas A., primary, Kabraji, Sheheryar, primary, Trusolino, Livio, primary, Bertotti, Andrea, primary, Sicinska, Ewa T., primary, Parikh, Aparna R., primary, Wolpin, Brian M., primary, Schrock, Alexa B., primary, Giannakis, Marios, primary, Ng, Kimmie, primary, Meyerhardt, Jeffrey A., primary, Hornick, Jason L., primary, Sethi, Nilay S., primary, and Cleary, James M., primary

Published
2024
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15. Supplementary Table 5 from RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer

Author

Singh, Harshabad, primary, Sahgal, Pranshu, primary, Kapner, Kevin, primary, Corsello, Steven M., primary, Gupta, Hersh, primary, Gujrathi, Rahul, primary, Li, Yvonne Y., primary, Cherniack, Andrew D., primary, El Alam, Raquelle, primary, Kerfoot, Joseph, primary, Andrews, Elizabeth, primary, Lee, Annette, primary, Nambiar, Chetan, primary, Hannigan, Alison M., primary, Remland, Joshua, primary, Brais, Lauren, primary, Leahy, Meghan E., primary, Rubinson, Douglas A., primary, Schlechter, Benjamin L., primary, Meyerson, Matthew, primary, Kuang, Yanan, primary, Paweletz, Cloud P., primary, Lee, Jessica K., primary, Quintanilha, Julia C.F., primary, Aguirre, Andrew J., primary, Perez, Kimberly J., primary, Huffman, Brandon M., primary, Rossi, Humberto, primary, Abrams, Thomas A., primary, Kabraji, Sheheryar, primary, Trusolino, Livio, primary, Bertotti, Andrea, primary, Sicinska, Ewa T., primary, Parikh, Aparna R., primary, Wolpin, Brian M., primary, Schrock, Alexa B., primary, Giannakis, Marios, primary, Ng, Kimmie, primary, Meyerhardt, Jeffrey A., primary, Hornick, Jason L., primary, Sethi, Nilay S., primary, and Cleary, James M., primary

Published
2024
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16. Supplementary Figure 5 from RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer

Author

Singh, Harshabad, primary, Sahgal, Pranshu, primary, Kapner, Kevin, primary, Corsello, Steven M., primary, Gupta, Hersh, primary, Gujrathi, Rahul, primary, Li, Yvonne Y., primary, Cherniack, Andrew D., primary, El Alam, Raquelle, primary, Kerfoot, Joseph, primary, Andrews, Elizabeth, primary, Lee, Annette, primary, Nambiar, Chetan, primary, Hannigan, Alison M., primary, Remland, Joshua, primary, Brais, Lauren, primary, Leahy, Meghan E., primary, Rubinson, Douglas A., primary, Schlechter, Benjamin L., primary, Meyerson, Matthew, primary, Kuang, Yanan, primary, Paweletz, Cloud P., primary, Lee, Jessica K., primary, Quintanilha, Julia C.F., primary, Aguirre, Andrew J., primary, Perez, Kimberly J., primary, Huffman, Brandon M., primary, Rossi, Humberto, primary, Abrams, Thomas A., primary, Kabraji, Sheheryar, primary, Trusolino, Livio, primary, Bertotti, Andrea, primary, Sicinska, Ewa T., primary, Parikh, Aparna R., primary, Wolpin, Brian M., primary, Schrock, Alexa B., primary, Giannakis, Marios, primary, Ng, Kimmie, primary, Meyerhardt, Jeffrey A., primary, Hornick, Jason L., primary, Sethi, Nilay S., primary, and Cleary, James M., primary

Published
2024
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17. Supplementary Table 2 from RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer

Author

Singh, Harshabad, primary, Sahgal, Pranshu, primary, Kapner, Kevin, primary, Corsello, Steven M., primary, Gupta, Hersh, primary, Gujrathi, Rahul, primary, Li, Yvonne Y., primary, Cherniack, Andrew D., primary, El Alam, Raquelle, primary, Kerfoot, Joseph, primary, Andrews, Elizabeth, primary, Lee, Annette, primary, Nambiar, Chetan, primary, Hannigan, Alison M., primary, Remland, Joshua, primary, Brais, Lauren, primary, Leahy, Meghan E., primary, Rubinson, Douglas A., primary, Schlechter, Benjamin L., primary, Meyerson, Matthew, primary, Kuang, Yanan, primary, Paweletz, Cloud P., primary, Lee, Jessica K., primary, Quintanilha, Julia C.F., primary, Aguirre, Andrew J., primary, Perez, Kimberly J., primary, Huffman, Brandon M., primary, Rossi, Humberto, primary, Abrams, Thomas A., primary, Kabraji, Sheheryar, primary, Trusolino, Livio, primary, Bertotti, Andrea, primary, Sicinska, Ewa T., primary, Parikh, Aparna R., primary, Wolpin, Brian M., primary, Schrock, Alexa B., primary, Giannakis, Marios, primary, Ng, Kimmie, primary, Meyerhardt, Jeffrey A., primary, Hornick, Jason L., primary, Sethi, Nilay S., primary, and Cleary, James M., primary

Published
2024
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18. Supplementary Table 9 from RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer

Author

Singh, Harshabad, primary, Sahgal, Pranshu, primary, Kapner, Kevin, primary, Corsello, Steven M., primary, Gupta, Hersh, primary, Gujrathi, Rahul, primary, Li, Yvonne Y., primary, Cherniack, Andrew D., primary, El Alam, Raquelle, primary, Kerfoot, Joseph, primary, Andrews, Elizabeth, primary, Lee, Annette, primary, Nambiar, Chetan, primary, Hannigan, Alison M., primary, Remland, Joshua, primary, Brais, Lauren, primary, Leahy, Meghan E., primary, Rubinson, Douglas A., primary, Schlechter, Benjamin L., primary, Meyerson, Matthew, primary, Kuang, Yanan, primary, Paweletz, Cloud P., primary, Lee, Jessica K., primary, Quintanilha, Julia C.F., primary, Aguirre, Andrew J., primary, Perez, Kimberly J., primary, Huffman, Brandon M., primary, Rossi, Humberto, primary, Abrams, Thomas A., primary, Kabraji, Sheheryar, primary, Trusolino, Livio, primary, Bertotti, Andrea, primary, Sicinska, Ewa T., primary, Parikh, Aparna R., primary, Wolpin, Brian M., primary, Schrock, Alexa B., primary, Giannakis, Marios, primary, Ng, Kimmie, primary, Meyerhardt, Jeffrey A., primary, Hornick, Jason L., primary, Sethi, Nilay S., primary, and Cleary, James M., primary

Published
2024
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19. Supplementary Table 7 from RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer

Author

Singh, Harshabad, primary, Sahgal, Pranshu, primary, Kapner, Kevin, primary, Corsello, Steven M., primary, Gupta, Hersh, primary, Gujrathi, Rahul, primary, Li, Yvonne Y., primary, Cherniack, Andrew D., primary, El Alam, Raquelle, primary, Kerfoot, Joseph, primary, Andrews, Elizabeth, primary, Lee, Annette, primary, Nambiar, Chetan, primary, Hannigan, Alison M., primary, Remland, Joshua, primary, Brais, Lauren, primary, Leahy, Meghan E., primary, Rubinson, Douglas A., primary, Schlechter, Benjamin L., primary, Meyerson, Matthew, primary, Kuang, Yanan, primary, Paweletz, Cloud P., primary, Lee, Jessica K., primary, Quintanilha, Julia C.F., primary, Aguirre, Andrew J., primary, Perez, Kimberly J., primary, Huffman, Brandon M., primary, Rossi, Humberto, primary, Abrams, Thomas A., primary, Kabraji, Sheheryar, primary, Trusolino, Livio, primary, Bertotti, Andrea, primary, Sicinska, Ewa T., primary, Parikh, Aparna R., primary, Wolpin, Brian M., primary, Schrock, Alexa B., primary, Giannakis, Marios, primary, Ng, Kimmie, primary, Meyerhardt, Jeffrey A., primary, Hornick, Jason L., primary, Sethi, Nilay S., primary, and Cleary, James M., primary

Published
2024
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20. Supplementary Figure 6 from RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer

Author

Singh, Harshabad, primary, Sahgal, Pranshu, primary, Kapner, Kevin, primary, Corsello, Steven M., primary, Gupta, Hersh, primary, Gujrathi, Rahul, primary, Li, Yvonne Y., primary, Cherniack, Andrew D., primary, El Alam, Raquelle, primary, Kerfoot, Joseph, primary, Andrews, Elizabeth, primary, Lee, Annette, primary, Nambiar, Chetan, primary, Hannigan, Alison M., primary, Remland, Joshua, primary, Brais, Lauren, primary, Leahy, Meghan E., primary, Rubinson, Douglas A., primary, Schlechter, Benjamin L., primary, Meyerson, Matthew, primary, Kuang, Yanan, primary, Paweletz, Cloud P., primary, Lee, Jessica K., primary, Quintanilha, Julia C.F., primary, Aguirre, Andrew J., primary, Perez, Kimberly J., primary, Huffman, Brandon M., primary, Rossi, Humberto, primary, Abrams, Thomas A., primary, Kabraji, Sheheryar, primary, Trusolino, Livio, primary, Bertotti, Andrea, primary, Sicinska, Ewa T., primary, Parikh, Aparna R., primary, Wolpin, Brian M., primary, Schrock, Alexa B., primary, Giannakis, Marios, primary, Ng, Kimmie, primary, Meyerhardt, Jeffrey A., primary, Hornick, Jason L., primary, Sethi, Nilay S., primary, and Cleary, James M., primary

Published
2024
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21. Supplementary Table 3 from RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer

Author

Singh, Harshabad, primary, Sahgal, Pranshu, primary, Kapner, Kevin, primary, Corsello, Steven M., primary, Gupta, Hersh, primary, Gujrathi, Rahul, primary, Li, Yvonne Y., primary, Cherniack, Andrew D., primary, El Alam, Raquelle, primary, Kerfoot, Joseph, primary, Andrews, Elizabeth, primary, Lee, Annette, primary, Nambiar, Chetan, primary, Hannigan, Alison M., primary, Remland, Joshua, primary, Brais, Lauren, primary, Leahy, Meghan E., primary, Rubinson, Douglas A., primary, Schlechter, Benjamin L., primary, Meyerson, Matthew, primary, Kuang, Yanan, primary, Paweletz, Cloud P., primary, Lee, Jessica K., primary, Quintanilha, Julia C.F., primary, Aguirre, Andrew J., primary, Perez, Kimberly J., primary, Huffman, Brandon M., primary, Rossi, Humberto, primary, Abrams, Thomas A., primary, Kabraji, Sheheryar, primary, Trusolino, Livio, primary, Bertotti, Andrea, primary, Sicinska, Ewa T., primary, Parikh, Aparna R., primary, Wolpin, Brian M., primary, Schrock, Alexa B., primary, Giannakis, Marios, primary, Ng, Kimmie, primary, Meyerhardt, Jeffrey A., primary, Hornick, Jason L., primary, Sethi, Nilay S., primary, and Cleary, James M., primary

Published
2024
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22. Supplementary Methods 1 from RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer

Author

Singh, Harshabad, primary, Sahgal, Pranshu, primary, Kapner, Kevin, primary, Corsello, Steven M., primary, Gupta, Hersh, primary, Gujrathi, Rahul, primary, Li, Yvonne Y., primary, Cherniack, Andrew D., primary, El Alam, Raquelle, primary, Kerfoot, Joseph, primary, Andrews, Elizabeth, primary, Lee, Annette, primary, Nambiar, Chetan, primary, Hannigan, Alison M., primary, Remland, Joshua, primary, Brais, Lauren, primary, Leahy, Meghan E., primary, Rubinson, Douglas A., primary, Schlechter, Benjamin L., primary, Meyerson, Matthew, primary, Kuang, Yanan, primary, Paweletz, Cloud P., primary, Lee, Jessica K., primary, Quintanilha, Julia C.F., primary, Aguirre, Andrew J., primary, Perez, Kimberly J., primary, Huffman, Brandon M., primary, Rossi, Humberto, primary, Abrams, Thomas A., primary, Kabraji, Sheheryar, primary, Trusolino, Livio, primary, Bertotti, Andrea, primary, Sicinska, Ewa T., primary, Parikh, Aparna R., primary, Wolpin, Brian M., primary, Schrock, Alexa B., primary, Giannakis, Marios, primary, Ng, Kimmie, primary, Meyerhardt, Jeffrey A., primary, Hornick, Jason L., primary, Sethi, Nilay S., primary, and Cleary, James M., primary

Published
2024
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23. Supplementary Figure 3 from RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer

Author

Singh, Harshabad, primary, Sahgal, Pranshu, primary, Kapner, Kevin, primary, Corsello, Steven M., primary, Gupta, Hersh, primary, Gujrathi, Rahul, primary, Li, Yvonne Y., primary, Cherniack, Andrew D., primary, El Alam, Raquelle, primary, Kerfoot, Joseph, primary, Andrews, Elizabeth, primary, Lee, Annette, primary, Nambiar, Chetan, primary, Hannigan, Alison M., primary, Remland, Joshua, primary, Brais, Lauren, primary, Leahy, Meghan E., primary, Rubinson, Douglas A., primary, Schlechter, Benjamin L., primary, Meyerson, Matthew, primary, Kuang, Yanan, primary, Paweletz, Cloud P., primary, Lee, Jessica K., primary, Quintanilha, Julia C.F., primary, Aguirre, Andrew J., primary, Perez, Kimberly J., primary, Huffman, Brandon M., primary, Rossi, Humberto, primary, Abrams, Thomas A., primary, Kabraji, Sheheryar, primary, Trusolino, Livio, primary, Bertotti, Andrea, primary, Sicinska, Ewa T., primary, Parikh, Aparna R., primary, Wolpin, Brian M., primary, Schrock, Alexa B., primary, Giannakis, Marios, primary, Ng, Kimmie, primary, Meyerhardt, Jeffrey A., primary, Hornick, Jason L., primary, Sethi, Nilay S., primary, and Cleary, James M., primary

Published
2024
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24. Supplementary Table 6 from RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer

Author

Singh, Harshabad, primary, Sahgal, Pranshu, primary, Kapner, Kevin, primary, Corsello, Steven M., primary, Gupta, Hersh, primary, Gujrathi, Rahul, primary, Li, Yvonne Y., primary, Cherniack, Andrew D., primary, El Alam, Raquelle, primary, Kerfoot, Joseph, primary, Andrews, Elizabeth, primary, Lee, Annette, primary, Nambiar, Chetan, primary, Hannigan, Alison M., primary, Remland, Joshua, primary, Brais, Lauren, primary, Leahy, Meghan E., primary, Rubinson, Douglas A., primary, Schlechter, Benjamin L., primary, Meyerson, Matthew, primary, Kuang, Yanan, primary, Paweletz, Cloud P., primary, Lee, Jessica K., primary, Quintanilha, Julia C.F., primary, Aguirre, Andrew J., primary, Perez, Kimberly J., primary, Huffman, Brandon M., primary, Rossi, Humberto, primary, Abrams, Thomas A., primary, Kabraji, Sheheryar, primary, Trusolino, Livio, primary, Bertotti, Andrea, primary, Sicinska, Ewa T., primary, Parikh, Aparna R., primary, Wolpin, Brian M., primary, Schrock, Alexa B., primary, Giannakis, Marios, primary, Ng, Kimmie, primary, Meyerhardt, Jeffrey A., primary, Hornick, Jason L., primary, Sethi, Nilay S., primary, and Cleary, James M., primary

Published
2024
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25. Supplementary Figure 2 from RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer

Author

Singh, Harshabad, primary, Sahgal, Pranshu, primary, Kapner, Kevin, primary, Corsello, Steven M., primary, Gupta, Hersh, primary, Gujrathi, Rahul, primary, Li, Yvonne Y., primary, Cherniack, Andrew D., primary, El Alam, Raquelle, primary, Kerfoot, Joseph, primary, Andrews, Elizabeth, primary, Lee, Annette, primary, Nambiar, Chetan, primary, Hannigan, Alison M., primary, Remland, Joshua, primary, Brais, Lauren, primary, Leahy, Meghan E., primary, Rubinson, Douglas A., primary, Schlechter, Benjamin L., primary, Meyerson, Matthew, primary, Kuang, Yanan, primary, Paweletz, Cloud P., primary, Lee, Jessica K., primary, Quintanilha, Julia C.F., primary, Aguirre, Andrew J., primary, Perez, Kimberly J., primary, Huffman, Brandon M., primary, Rossi, Humberto, primary, Abrams, Thomas A., primary, Kabraji, Sheheryar, primary, Trusolino, Livio, primary, Bertotti, Andrea, primary, Sicinska, Ewa T., primary, Parikh, Aparna R., primary, Wolpin, Brian M., primary, Schrock, Alexa B., primary, Giannakis, Marios, primary, Ng, Kimmie, primary, Meyerhardt, Jeffrey A., primary, Hornick, Jason L., primary, Sethi, Nilay S., primary, and Cleary, James M., primary

Published
2024
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26. Supplementary Table 4 from RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer

Author

Singh, Harshabad, primary, Sahgal, Pranshu, primary, Kapner, Kevin, primary, Corsello, Steven M., primary, Gupta, Hersh, primary, Gujrathi, Rahul, primary, Li, Yvonne Y., primary, Cherniack, Andrew D., primary, El Alam, Raquelle, primary, Kerfoot, Joseph, primary, Andrews, Elizabeth, primary, Lee, Annette, primary, Nambiar, Chetan, primary, Hannigan, Alison M., primary, Remland, Joshua, primary, Brais, Lauren, primary, Leahy, Meghan E., primary, Rubinson, Douglas A., primary, Schlechter, Benjamin L., primary, Meyerson, Matthew, primary, Kuang, Yanan, primary, Paweletz, Cloud P., primary, Lee, Jessica K., primary, Quintanilha, Julia C.F., primary, Aguirre, Andrew J., primary, Perez, Kimberly J., primary, Huffman, Brandon M., primary, Rossi, Humberto, primary, Abrams, Thomas A., primary, Kabraji, Sheheryar, primary, Trusolino, Livio, primary, Bertotti, Andrea, primary, Sicinska, Ewa T., primary, Parikh, Aparna R., primary, Wolpin, Brian M., primary, Schrock, Alexa B., primary, Giannakis, Marios, primary, Ng, Kimmie, primary, Meyerhardt, Jeffrey A., primary, Hornick, Jason L., primary, Sethi, Nilay S., primary, and Cleary, James M., primary

Published
2024
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27. Supplementary Figure 4 from RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer

Author

Singh, Harshabad, primary, Sahgal, Pranshu, primary, Kapner, Kevin, primary, Corsello, Steven M., primary, Gupta, Hersh, primary, Gujrathi, Rahul, primary, Li, Yvonne Y., primary, Cherniack, Andrew D., primary, El Alam, Raquelle, primary, Kerfoot, Joseph, primary, Andrews, Elizabeth, primary, Lee, Annette, primary, Nambiar, Chetan, primary, Hannigan, Alison M., primary, Remland, Joshua, primary, Brais, Lauren, primary, Leahy, Meghan E., primary, Rubinson, Douglas A., primary, Schlechter, Benjamin L., primary, Meyerson, Matthew, primary, Kuang, Yanan, primary, Paweletz, Cloud P., primary, Lee, Jessica K., primary, Quintanilha, Julia C.F., primary, Aguirre, Andrew J., primary, Perez, Kimberly J., primary, Huffman, Brandon M., primary, Rossi, Humberto, primary, Abrams, Thomas A., primary, Kabraji, Sheheryar, primary, Trusolino, Livio, primary, Bertotti, Andrea, primary, Sicinska, Ewa T., primary, Parikh, Aparna R., primary, Wolpin, Brian M., primary, Schrock, Alexa B., primary, Giannakis, Marios, primary, Ng, Kimmie, primary, Meyerhardt, Jeffrey A., primary, Hornick, Jason L., primary, Sethi, Nilay S., primary, and Cleary, James M., primary

Published
2024
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28. Data from RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer

Author

Singh, Harshabad, primary, Sahgal, Pranshu, primary, Kapner, Kevin, primary, Corsello, Steven M., primary, Gupta, Hersh, primary, Gujrathi, Rahul, primary, Li, Yvonne Y., primary, Cherniack, Andrew D., primary, El Alam, Raquelle, primary, Kerfoot, Joseph, primary, Andrews, Elizabeth, primary, Lee, Annette, primary, Nambiar, Chetan, primary, Hannigan, Alison M., primary, Remland, Joshua, primary, Brais, Lauren, primary, Leahy, Meghan E., primary, Rubinson, Douglas A., primary, Schlechter, Benjamin L., primary, Meyerson, Matthew, primary, Kuang, Yanan, primary, Paweletz, Cloud P., primary, Lee, Jessica K., primary, Quintanilha, Julia C.F., primary, Aguirre, Andrew J., primary, Perez, Kimberly J., primary, Huffman, Brandon M., primary, Rossi, Humberto, primary, Abrams, Thomas A., primary, Kabraji, Sheheryar, primary, Trusolino, Livio, primary, Bertotti, Andrea, primary, Sicinska, Ewa T., primary, Parikh, Aparna R., primary, Wolpin, Brian M., primary, Schrock, Alexa B., primary, Giannakis, Marios, primary, Ng, Kimmie, primary, Meyerhardt, Jeffrey A., primary, Hornick, Jason L., primary, Sethi, Nilay S., primary, and Cleary, James M., primary

Published
2024
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29. Programmatic Precision Oncology Decision Support for Patients With Gastrointestinal Cancer

Author

Keller, Rachel B., Mazor, Tali, Sholl, Lynette, Aguirre, Andrew J., Singh, Harshabad, Sethi, Nilay, Bass, Adam, Nagaraja, Ankur K., Brais, Lauren K., Hill, Emma, Hennessey, Connor, Cusick, Margaret, Del Vecchio Fitz, Catherine, Zwiesler, Zachary, Siegel, Ethan, Ovalle, Andrea, Trukhanov, Pavel, Hansel, Jason, Shapiro, Geoffrey I., Abrams, Thomas A., Biller, Leah H., Chan, Jennifer A., Cleary, James M., Corsello, Steven M., Enzinger, Andrea C., Enzinger, Peter C., Mayer, Robert J., McCleary, Nadine J., Meyerhardt, Jeffrey A., Ng, Kimmie, Patel, Anuj K., Perez, Kimberley J., Rahma, Osama E., Rubinson, Douglas A., Wisch, Jeffrey S., Yurgelun, Matthew B., Hassett, Michael J., MacConaill, Laura, Schrag, Deborah, Cerami, Ethan, Wolpin, Brian M., Nowak, Jonathan A., and Giannakis, Marios

Published
2023
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30. Lead-Time Trajectory of CA19-9 as an Anchor Marker for Pancreatic Cancer Early Detection

Author

Fahrmann, Johannes F., Schmidt, C. Max, Mao, Xiangying, Irajizad, Ehsan, Loftus, Maureen, Zhang, Jinming, Patel, Nikul, Vykoukal, Jody, Dennison, Jennifer B., Long, James P., Do, Kim-Anh, Zhang, Jianjun, Chabot, John A., Kluger, Michael D., Kastrinos, Fay, Brais, Lauren, Babic, Ana, Jajoo, Kunal, Lee, Linda S., Clancy, Thomas E., Ng, Kimmie, Bullock, Andrea, Genkinger, Jeanine, Yip-Schneider, Michele T., Maitra, Anirban, Wolpin, Brian M., and Hanash, Samir

Published
2021
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31. Sotorasib Is a Pan-RASG12C Inhibitor Capable of Driving Clinical Response in NRASG12C Cancers

Author

Rubinson, Douglas A., primary, Tanaka, Noritaka, additional, Fece de la Cruz, Ferran, additional, Kapner, Kevin S., additional, Rosenthal, Michael H., additional, Norden, Bryanna L., additional, Barnes, Haley, additional, Ehnstrom, Sara, additional, Morales-Giron, Alvin A., additional, Brais, Lauren K., additional, Lemke, Christopher T., additional, Aguirre, Andrew J., additional, and Corcoran, Ryan B., additional

Published
2024
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32. Protein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer

Author

Ben-Ami, Roni, primary, Wang, Qiao-Li, additional, Zhang, Jinming, additional, Supplee, Julianna G, additional, Fahrmann, Johannes F, additional, Lehmann-Werman, Roni, additional, Brais, Lauren K, additional, Nowak, Jonathan, additional, Yuan, Chen, additional, Loftus, Maureen, additional, Babic, Ana, additional, Irajizad, Ehsan, additional, Davidi, Tal, additional, Zick, Aviad, additional, Hubert, Ayala, additional, Neiman, Daniel, additional, Piyanzin, Sheina, additional, Gal-Rosenberg, Ofer, additional, Horn, Amit, additional, Shemer, Ruth, additional, Glaser, Benjamin, additional, Boos, Natalia, additional, Jajoo, Kunal, additional, Lee, Linda, additional, Clancy, Thomas E, additional, Rubinson, Douglas A, additional, Ng, Kimmie, additional, Chabot, John A, additional, Kastrinos, Fay, additional, Kluger, Michael, additional, Aguirre, Andrew J, additional, Jänne, Pasi A, additional, Bardeesy, Nabeel, additional, Stanger, Ben, additional, O'Hara, Mark H, additional, Till, Jacob, additional, Maitra, Anirban, additional, Carpenter, Erica L, additional, Bullock, Andrea J, additional, Genkinger, Jeanine, additional, Hanash, Samir M, additional, Paweletz, Cloud P, additional, Dor, Yuval, additional, and Wolpin, Brian M, additional

Published
2023
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35. Supplementary Figure S3 from Oncogenic Drivers and Therapeutic Vulnerabilities in KRAS Wild-Type Pancreatic Cancer

Author

Singh, Harshabad, primary, Keller, Rachel B., primary, Kapner, Kevin S., primary, Dilly, Julien, primary, Raghavan, Srivatsan, primary, Yuan, Chen, primary, Cohen, Elizabeth F., primary, Tolstorukov, Michael, primary, Andrews, Elizabeth, primary, Brais, Lauren K., primary, da Silva, Annacarolina, primary, Perez, Kimberly, primary, Rubinson, Douglas A., primary, Surana, Rishi, primary, Giannakis, Marios, primary, Ng, Kimmie, primary, Clancy, Thomas E., primary, Yurgelun, Matthew B., primary, Schlechter, Benjamin L., primary, Clark, Jeffrey W., primary, Shapiro, Geoffrey I., primary, Rosenthal, Michael H., primary, Hornick, Jason L., primary, Nardi, Valentina, primary, Li, Yvonne Y., primary, Gupta, Hersh, primary, Cherniack, Andrew D., primary, Meyerson, Matthew, primary, Cleary, James M., primary, Nowak, Jonathan A., primary, Wolpin, Brian M., primary, and Aguirre, Andrew J., primary

Published
2023
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36. Supplementary Table S8 from Oncogenic Drivers and Therapeutic Vulnerabilities in KRAS Wild-Type Pancreatic Cancer

Author

Singh, Harshabad, primary, Keller, Rachel B., primary, Kapner, Kevin S., primary, Dilly, Julien, primary, Raghavan, Srivatsan, primary, Yuan, Chen, primary, Cohen, Elizabeth F., primary, Tolstorukov, Michael, primary, Andrews, Elizabeth, primary, Brais, Lauren K., primary, da Silva, Annacarolina, primary, Perez, Kimberly, primary, Rubinson, Douglas A., primary, Surana, Rishi, primary, Giannakis, Marios, primary, Ng, Kimmie, primary, Clancy, Thomas E., primary, Yurgelun, Matthew B., primary, Schlechter, Benjamin L., primary, Clark, Jeffrey W., primary, Shapiro, Geoffrey I., primary, Rosenthal, Michael H., primary, Hornick, Jason L., primary, Nardi, Valentina, primary, Li, Yvonne Y., primary, Gupta, Hersh, primary, Cherniack, Andrew D., primary, Meyerson, Matthew, primary, Cleary, James M., primary, Nowak, Jonathan A., primary, Wolpin, Brian M., primary, and Aguirre, Andrew J., primary

Published
2023
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37. Data from Oncogenic Drivers and Therapeutic Vulnerabilities in KRAS Wild-Type Pancreatic Cancer

Author

Singh, Harshabad, primary, Keller, Rachel B., primary, Kapner, Kevin S., primary, Dilly, Julien, primary, Raghavan, Srivatsan, primary, Yuan, Chen, primary, Cohen, Elizabeth F., primary, Tolstorukov, Michael, primary, Andrews, Elizabeth, primary, Brais, Lauren K., primary, da Silva, Annacarolina, primary, Perez, Kimberly, primary, Rubinson, Douglas A., primary, Surana, Rishi, primary, Giannakis, Marios, primary, Ng, Kimmie, primary, Clancy, Thomas E., primary, Yurgelun, Matthew B., primary, Schlechter, Benjamin L., primary, Clark, Jeffrey W., primary, Shapiro, Geoffrey I., primary, Rosenthal, Michael H., primary, Hornick, Jason L., primary, Nardi, Valentina, primary, Li, Yvonne Y., primary, Gupta, Hersh, primary, Cherniack, Andrew D., primary, Meyerson, Matthew, primary, Cleary, James M., primary, Nowak, Jonathan A., primary, Wolpin, Brian M., primary, and Aguirre, Andrew J., primary

Published
2023
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38. Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors

Author

Hoffman, Samantha E., primary, Dowrey, Todd W., additional, Villacorta Martin, Carlos, additional, Bi, Kevin, additional, Titchen, Breanna, additional, Johri, Shreya, additional, DelloStritto, Laura, additional, Patel, Miraj, additional, Mackichan, Colin, additional, Inga, Stephanie, additional, Chen, Judy, additional, Grimaldi, Grace, additional, Napolitano, Sara, additional, Wakiro, Isaac, additional, Wu, Jingyi, additional, Yeung, Jason, additional, Rotem, Asaf, additional, Sicinska, Ewa, additional, Shannon, Erin, additional, Clancy, Thomas, additional, Wang, Jiping, additional, Denning, Sarah, additional, Brais, Lauren, additional, Besson, Naomi R., additional, Pfaff, Kathleen L., additional, Huang, Ying, additional, Kao, Katrina Z., additional, Rodig, Scott, additional, Hornick, Jason L., additional, Vigneau, Sebastien, additional, Park, Jihye, additional, Kulke, Matthew H., additional, Chan, Jennifer, additional, Van Allen, Eliezer M., additional, and Murphy, George J., additional

Published
2023
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39. Supplementary Figure S2 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization

Author

King, Sontoria D., primary, Veliginti, Swathi, primary, Brouwers, Martijn C.G.J., primary, Ren, Zhewen, primary, Zheng, Wei, primary, Setiawan, Veronica W., primary, Wilkens, Lynne R., primary, Shu, Xiao-Ou, primary, Arslan, Alan A., primary, Beane Freeman, Laura E., primary, Bracci, Paige M., primary, Canzian, Federico, primary, Du, Mengmeng, primary, Gallinger, Steven J., primary, Giles, Graham G., primary, Goodman, Phyllis J., primary, Haiman, Christopher A., primary, Kogevinas, Manolis, primary, Kooperberg, Charles, primary, LeMarchand, Loic, primary, Neale, Rachel E., primary, Visvanathan, Kala, primary, White, Emily, primary, Albanes, Demetrius, primary, Andreotti, Gabriella, primary, Babic, Ana, primary, Berndt, Sonja I., primary, Brais, Lauren K., primary, Brennan, Paul, primary, Buring, Julie E., primary, Rabe, Kari G., primary, Bamlet, William R., primary, Chanock, Stephen J., primary, Fuchs, Charles S., primary, Gaziano, J. Michael, primary, Giovannucci, Edward L., primary, Hackert, Thilo, primary, Hassan, Manal M., primary, Katzke, Verena, primary, Kurtz, Robert C., primary, Lee, I.-Min, primary, Malats, Núria, primary, Murphy, Neil, primary, Oberg, Ann L., primary, Orlow, Irene, primary, Porta, Miquel, primary, Real, Francisco X., primary, Rothman, Nathaniel, primary, Sesso, Howard D., primary, Silverman, Debra T., primary, Thompson, Ian M., primary, Wactawski-Wende, Jean, primary, Wang, Xiaoliang, primary, Wentzensen, Nicolas, primary, Yu, Herbert, primary, Zeleniuch-Jacquotte, Anne, primary, Yu, Kai, primary, Wolpin, Brian M., primary, Duell, Eric J., primary, Li, Donghui, primary, Hung, Rayjean J., primary, Perdomo, Sandra, primary, McCullough, Marjorie L., primary, Freedman, Neal D., primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Riboli, Elio, primary, Sund, Malin, primary, Tjønneland, Anne, primary, Zhong, Jun, primary, Van Den Eeden, Stephen K., primary, Kraft, Peter, primary, Risch, Harvey A., primary, Amundadottir, Laufey T., primary, Klein, Alison P., primary, Stolzenberg-Solomon, Rachael Z., primary, and Antwi, Samuel O., primary

Published
2023
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40. Supplementary Table S6 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization

Author

King, Sontoria D., primary, Veliginti, Swathi, primary, Brouwers, Martijn C.G.J., primary, Ren, Zhewen, primary, Zheng, Wei, primary, Setiawan, Veronica W., primary, Wilkens, Lynne R., primary, Shu, Xiao-Ou, primary, Arslan, Alan A., primary, Beane Freeman, Laura E., primary, Bracci, Paige M., primary, Canzian, Federico, primary, Du, Mengmeng, primary, Gallinger, Steven J., primary, Giles, Graham G., primary, Goodman, Phyllis J., primary, Haiman, Christopher A., primary, Kogevinas, Manolis, primary, Kooperberg, Charles, primary, LeMarchand, Loic, primary, Neale, Rachel E., primary, Visvanathan, Kala, primary, White, Emily, primary, Albanes, Demetrius, primary, Andreotti, Gabriella, primary, Babic, Ana, primary, Berndt, Sonja I., primary, Brais, Lauren K., primary, Brennan, Paul, primary, Buring, Julie E., primary, Rabe, Kari G., primary, Bamlet, William R., primary, Chanock, Stephen J., primary, Fuchs, Charles S., primary, Gaziano, J. Michael, primary, Giovannucci, Edward L., primary, Hackert, Thilo, primary, Hassan, Manal M., primary, Katzke, Verena, primary, Kurtz, Robert C., primary, Lee, I.-Min, primary, Malats, Núria, primary, Murphy, Neil, primary, Oberg, Ann L., primary, Orlow, Irene, primary, Porta, Miquel, primary, Real, Francisco X., primary, Rothman, Nathaniel, primary, Sesso, Howard D., primary, Silverman, Debra T., primary, Thompson, Ian M., primary, Wactawski-Wende, Jean, primary, Wang, Xiaoliang, primary, Wentzensen, Nicolas, primary, Yu, Herbert, primary, Zeleniuch-Jacquotte, Anne, primary, Yu, Kai, primary, Wolpin, Brian M., primary, Duell, Eric J., primary, Li, Donghui, primary, Hung, Rayjean J., primary, Perdomo, Sandra, primary, McCullough, Marjorie L., primary, Freedman, Neal D., primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Riboli, Elio, primary, Sund, Malin, primary, Tjønneland, Anne, primary, Zhong, Jun, primary, Van Den Eeden, Stephen K., primary, Kraft, Peter, primary, Risch, Harvey A., primary, Amundadottir, Laufey T., primary, Klein, Alison P., primary, Stolzenberg-Solomon, Rachael Z., primary, and Antwi, Samuel O., primary

Published
2023
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41. Data from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization

Author

King, Sontoria D., primary, Veliginti, Swathi, primary, Brouwers, Martijn C.G.J., primary, Ren, Zhewen, primary, Zheng, Wei, primary, Setiawan, Veronica W., primary, Wilkens, Lynne R., primary, Shu, Xiao-Ou, primary, Arslan, Alan A., primary, Beane Freeman, Laura E., primary, Bracci, Paige M., primary, Canzian, Federico, primary, Du, Mengmeng, primary, Gallinger, Steven J., primary, Giles, Graham G., primary, Goodman, Phyllis J., primary, Haiman, Christopher A., primary, Kogevinas, Manolis, primary, Kooperberg, Charles, primary, LeMarchand, Loic, primary, Neale, Rachel E., primary, Visvanathan, Kala, primary, White, Emily, primary, Albanes, Demetrius, primary, Andreotti, Gabriella, primary, Babic, Ana, primary, Berndt, Sonja I., primary, Brais, Lauren K., primary, Brennan, Paul, primary, Buring, Julie E., primary, Rabe, Kari G., primary, Bamlet, William R., primary, Chanock, Stephen J., primary, Fuchs, Charles S., primary, Gaziano, J. Michael, primary, Giovannucci, Edward L., primary, Hackert, Thilo, primary, Hassan, Manal M., primary, Katzke, Verena, primary, Kurtz, Robert C., primary, Lee, I.-Min, primary, Malats, Núria, primary, Murphy, Neil, primary, Oberg, Ann L., primary, Orlow, Irene, primary, Porta, Miquel, primary, Real, Francisco X., primary, Rothman, Nathaniel, primary, Sesso, Howard D., primary, Silverman, Debra T., primary, Thompson, Ian M., primary, Wactawski-Wende, Jean, primary, Wang, Xiaoliang, primary, Wentzensen, Nicolas, primary, Yu, Herbert, primary, Zeleniuch-Jacquotte, Anne, primary, Yu, Kai, primary, Wolpin, Brian M., primary, Duell, Eric J., primary, Li, Donghui, primary, Hung, Rayjean J., primary, Perdomo, Sandra, primary, McCullough, Marjorie L., primary, Freedman, Neal D., primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Riboli, Elio, primary, Sund, Malin, primary, Tjønneland, Anne, primary, Zhong, Jun, primary, Van Den Eeden, Stephen K., primary, Kraft, Peter, primary, Risch, Harvey A., primary, Amundadottir, Laufey T., primary, Klein, Alison P., primary, Stolzenberg-Solomon, Rachael Z., primary, and Antwi, Samuel O., primary

Published
2023
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42. Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer

Author

Yurgelun, Matthew B., Chittenden, Anu B., Morales-Oyarvide, Vicente, Rubinson, Douglas A., Dunne, Richard F., Kozak, Margaret M., Qian, Zhi Rong, Welch, Marisa W., Brais, Lauren K., Da Silva, Annacarolina, Bui, Justin L., Yuan, Chen, Li, Tingting, Li, Wanwan, Masuda, Atsuhiro, Gu, Mancang, Bullock, Andrea J., Chang, Daniel T., Clancy, Thomas E., Linehan, David C., Findeis-Hosey, Jennifer J., Doyle, Leona A., Thorner, Aaron R., Ducar, Matthew D., Wollison, Bruce M., Khalaf, Natalia, Perez, Kimberly, Syngal, Sapna, Aguirre, Andrew J., Hahn, William C., Meyerson, Matthew L., Fuchs, Charles S., Ogino, Shuji, Hornick, Jason L., Hezel, Aram F., Koong, Albert C., Nowak, Jonathan A., and Wolpin, Brian M.

Published
2019
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44. Oncogenic drivers and therapeutic vulnerabilities in KRAS wild-type pancreatic cancer

Author

Singh, Harshabad, primary, Keller, Rachel B., additional, Kapner, Kevin S., additional, Dilly, Julien, additional, Raghavan, Srivatsan, additional, Yuan, Chen, additional, Cohen, Elizabeth F., additional, Tolstorukov, Michael, additional, Andrews, Elizabeth, additional, Brais, Lauren K., additional, da Silva, Annacarolina, additional, Perez, Kimberly, additional, Rubinson, Douglas A., additional, Surana, Rishi, additional, Giannakis, Marios, additional, Ng, Kimmie, additional, Clancy, Thomas E., additional, Yurgelun, Matthew B., additional, Schlechter, Benjamin L., additional, Clark, Jeffrey W., additional, Shapiro, Geoffrey I., additional, Rosenthal, Michael H., additional, Hornick, Jason L., additional, Nardi, Valentina, additional, Li, Yvonne Y., additional, Gupta, Hersh, additional, Cherniack, Andrew D., additional, Meyerson, Matthew, additional, Cleary, James M., additional, Nowak, Jonathan A., additional, Wolpin, Brian M., additional, and Aguirre, Andrew J., additional

Published
2023
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45. Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization

Author

King, Sontoria D., primary, Veliginti, Swathi, additional, Brouwers, Martijn C.G.J., additional, Ren, Zhewen, additional, Zheng, Wei, additional, Setiawan, Veronica W., additional, Wilkens, Lynne R., additional, Shu, Xiao-Ou, additional, Arslan, Alan A., additional, Beane Freeman, Laura E., additional, Bracci, Paige M., additional, Canzian, Federico, additional, Du, Mengmeng, additional, Gallinger, Steven J., additional, Giles, Graham G., additional, Goodman, Phyllis J., additional, Haiman, Christopher A., additional, Kogevinas, Manolis, additional, Kooperberg, Charles, additional, LeMarchand, Loic, additional, Neale, Rachel E., additional, Visvanathan, Kala, additional, White, Emily, additional, Albanes, Demetrius, additional, Andreotti, Gabriella, additional, Babic, Ana, additional, Berndt, Sonja I., additional, Brais, Lauren K., additional, Brennan, Paul, additional, Buring, Julie E., additional, Rabe, Kari G., additional, Bamlet, William R., additional, Chanock, Stephen J., additional, Fuchs, Charles S., additional, Gaziano, J. Michael, additional, Giovannucci, Edward L., additional, Hackert, Thilo, additional, Hassan, Manal M., additional, Katzke, Verena, additional, Kurtz, Robert C., additional, Lee, I.-Min, additional, Malats, Núria, additional, Murphy, Neil, additional, Oberg, Ann L., additional, Orlow, Irene, additional, Porta, Miquel, additional, Real, Francisco X., additional, Rothman, Nathaniel, additional, Sesso, Howard D., additional, Silverman, Debra T., additional, Thompson, Ian M., additional, Wactawski-Wende, Jean, additional, Wang, Xiaoliang, additional, Wentzensen, Nicolas, additional, Yu, Herbert, additional, Zeleniuch-Jacquotte, Anne, additional, Yu, Kai, additional, Wolpin, Brian M., additional, Duell, Eric J., additional, Li, Donghui, additional, Hung, Rayjean J., additional, Perdomo, Sandra, additional, McCullough, Marjorie L., additional, Freedman, Neal D., additional, Patel, Alpa V., additional, Peters, Ulrike, additional, Riboli, Elio, additional, Sund, Malin, additional, Tjønneland, Anne, additional, Zhong, Jun, additional, Van Den Eeden, Stephen K., additional, Kraft, Peter, additional, Risch, Harvey A., additional, Amundadottir, Laufey T., additional, Klein, Alison P., additional, Stolzenberg-Solomon, Rachael Z., additional, and Antwi, Samuel O., additional

Published
2023
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46. G-CSF rescue of FOLFIRINOX-induced neutropenia leads to systemic immune suppression in mice and humans

Author

Cardot-Ruffino, Victoire, primary, Bollenrucher, Naima, additional, Delius, Luisa, additional, Wang, S Jennifer, additional, Brais, Lauren K, additional, Remland, Joshua, additional, Keheler, C Elizabeth, additional, Sullivan, Keri M, additional, Abrams, Thomas A, additional, Biller, Leah H, additional, Enzinger, Peter C, additional, McCleary, Nadine J, additional, Patel, Anuj K, additional, Rubinson, Douglas A, additional, Schlechter, Benjamin, additional, Slater, Sarah, additional, Yurgelun, Matthew B, additional, Cleary, James M, additional, Perez, Kimberly, additional, Dougan, Michael, additional, Ng, Kimmie, additional, Wolpin, Brian M, additional, Singh, Harshabad, additional, and Dougan, Stephanie K, additional

Published
2023
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48. Altered exocrine function can drive adipose wasting in early pancreatic cancer

Author

Danai, Laura V., Babic, Ana, Rosenthal, Michael H., Dennstedt, Emily A., Muir, Alexander, Lien, Evan C., Mayers, Jared R., Tai, Karen, Lau, Allison N., Jones-Sali, Paul, Prado, Carla M., Petersen, Gloria M., Takahashi, Naoki, Sugimoto, Motokazu, Yeh, Jen Jen, Lopez, Nicole, Bardeesy, Nabeel, Fernandez-del Castillo, Carlos, Liss, Andrew S., Koong, Albert C., Bui, Justin, Yuan, Chen, Welch, Marisa W., Brais, Lauren K., Kulke, Matthew H., Dennis, Courtney, Clish, Clary B., Wolpin, Brian M., and Vander Heiden, Matthew G.

Published
2018
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49. Abstract CT155: Long term results and ctDNA correlatives for CAPOX BETR: A multi-center phase II trial of capecitabine, oxaliplatin, bevacizumab and trastuzumab for previously untreated HER2 positive metastatic gastroesophageal adenocarcinoma

Author

Singh, Harshabad, primary, Lowder, Kristen E., additional, Kapner, Kevin, additional, Kelly, Ronan J., additional, Zheng, Hui, additional, McCleary, Nadine J., additional, Abrams, Thomas A., additional, Chan, Jennifer A., additional, Regan, Eileen M., additional, Klempner, Samuel J., additional, Hannigan, Alison M., additional, Brais, Lauren K., additional, Andrews, Elizabeth A., additional, Yurgelun, Matthew B., additional, Cleary, James M., additional, Rubinson, Douglas A., additional, Ritterhouse, Lauren L., additional, Maron, Garrett E., additional, Aguirre, Andrew J., additional, Tan, Lu, additional, Du, Pan, additional, Meyerhardt, Jeffrey A., additional, Gardecki, Emma, additional, Lennerz, Jochen K., additional, Jia, Shidong, additional, Wolpin, Brian M., additional, and Enzinger, Peter C., additional

Published
2023
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50. Table S1: Somatic Mutations from Intrinsic Resistance to Immune Checkpoint Blockade in a Mismatch Repair–Deficient Colorectal Cancer

Author

Gurjao, Carino, primary, Liu, David, primary, Hofree, Matan, primary, AlDubayan, Saud H., primary, Wakiro, Isaac, primary, Su, Mei-Ju, primary, Felt, Kristen, primary, Gjini, Evisa, primary, Brais, Lauren K., primary, Rotem, Asaf, primary, Rosenthal, Michael H., primary, Rozenblatt-Rosen, Orit, primary, Rodig, Scott, primary, Ng, Kimmie, primary, Van Allen, Eliezer M., primary, Corsello, Steven M., primary, Ogino, Shuji, primary, Regev, Aviv, primary, Nowak, Jonathan A., primary, and Giannakis, Marios, primary

Published
2023
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