Search

PURPOSE: Androgen receptor splice variant 7 (ARV-7) is a resistance mechanism to hormonal therapy in metastatic castrate-resistant prostate cancer (mCRPC). It has been associated with poor outcomes. On progression to castrate resistance, ARV-7 positivity has been identified in global populations at an incidence of 17.8%-28.8%. Here, we characterize the incidence of ARV-7 positivity in Asian patients with mCRPC in a prospective fashion and evaluate its implications on treatment outcomes. METHODS: Patients with mCRPC from multiple centers in Southeast and East Asia were enrolled in a prospective manner before initiation of androgen receptor signaling inhibitors or docetaxel. ARV-7 status was evaluated at baseline with three commercially available assays: AdnaTest Prostate Cancer platform, Clearbridge method, and IBN method. Clinical outcomes at progression were assessed. The primary end point of this study was prevalence of ARV-7 positivity; secondary end points were incidence of ARV-7 positivity, prostate specific antigen (PSA) response rate, PSA progression-free survival (PFS), and overall survival (OS). RESULTS: A total of 102 patients with a median age of 72 years at enrollment participated. Overall, an incidence of ARV-7 positivity of between 14.3% and 33.7% in Asian patients with mCRPC was demonstrated depending on the assay used. Patients found to have ARV-7 positivity at enrollment had a numerically worse PSA PFS compared with ARV-7 negative patients. CONCLUSION: In this study, the incidence of ARV-7 positivity in Asian patients with mCRPC was shown to be similar to the global population. Patients with ARV-7 positivity appear to have more aggressive disease with numerically worse PSA PFS and OS. Further prospective studies are needed to fully characterize the relationship that ARV-7 positivity has on prognosis of Asian patients with mCRPC. AR-V7 expression is correlated with clinical outcomes post-treatment in large multicenter Asian mCRPC patient study. [ABSTRACT FROM AUTHOR]

This work introduces Spiromni, a single device incorporating three different pressurised metered-dose inhaler (pMDI) accessories: a pMDI spacer, an electronic monitoring device (EMD), and a spirometer. While there are devices made to individually address the issues of technique, adherence and monitoring, respectively, for asthma patients as laid out in the Global Initiative for Asthma's (GINA) global strategy for asthma management and prevention, Spiromni was designed to address all three issues using a single, combination device. Spiromni addresses the key challenge of measuring both inhalation and exhalation profiles, which are different by an order of magnitude. Moreover, the innovative design prevents exhalation from entering the spacer chamber and prevents medication loss during inhalation using umbrella valves without a loss in flow velocity. Apart from recording the peak exhalation flow rate, data from the sensors allow us to extract other key lung volume and capacities measures similar to a medical pulmonary function test. We believe this low-cost portable multi-functional device will benefit both asthma patients and clinicians in the management of the disease. [ABSTRACT FROM AUTHOR]

Queer refugees are misfits in the global political economy of migration. While international human rights law has provided some room for queer acceptance, queer refugees face organised abandonment—marginality, erasure, and invisibility—as they attempt to survive in the face of ongoing displacement. This paper explores queer refugee survival in Nairobi, Cape Town, and Paris, and examines the netted practices of the state, non‐state actors, and civil society embedded in a landscape of heteronormativity and anti‐migrant sentiment. In so doing, this paper emphasises queerness as a form of precarity inseparable from the overarching violence of race, class, and capital. With this critique in mind, queer refugee survival is constrained by the lack of access to shelter, community, and work‐related social reproduction. In short, queer refugees face deeper marginality than their cis‐gendered and heterosexual counterparts as they attempt to survive in the city. [ABSTRACT FROM AUTHOR]

In this exploratory article, we aim to open a research agenda for renewed attention to the relationship between the capitalist state and the technology ecosystem. Over the last decade, private technology companies have increasingly become enmeshed with the activities of the state in arenas such as policing, healthcare, and welfare administration. At a time when so many facets of state activity are being infiltrated by technology firms and their products, we ask how we should theorise the relationship between the capitalist state and technology capital? This paper develops one approach to answer this question by aligning the priorities of tech capital with those of the neoliberal state namely, through the disciplining and managing of the relative surplus population. In this arena, we argue, a form of techfare has begun to take shape: a technology-assisted extension and intensification of the disciplinary logics that work to lock the relative surplus population into exploitative market relations and punitive institutions in advanced capitalist countries like the United States. We explore techfare and the disciplining of labour through two avenues: the business of consumer finance vis-à-vis debt and credit instruments, and various forms of tech-enabled strategies of law-enforcement. [ABSTRACT FROM AUTHOR]

We report a new technique for sensitive, quantitative and rapid detection of Plasmodium spp.-infected red blood cells (RBCs) by means of magnetic resonance relaxometry (MRR). During the intraerythrocytic cycle, malaria parasites metabolize large amounts of cellular hemoglobin and convert it into hemozoin crystallites. We exploit the relatively large paramagnetic susceptibility of these hemozoin particles, which induce substantial changes in the transverse relaxation rate of proton nuclear magnetic resonance of RBCs, to infer the 'parasite load' in blood. Using an inexpensive benchtop 0.5-Tesla MRR system, we show that with minimal sample preparatory steps and without any chemical or immunolabeling, a parasitemia level of fewer than ten parasites per microliter in a volume below 10 ml of whole blood is detected in a few minutes. We demonstrate this method both for cultured Plasmodium falciparum parasites and in vivo with Plasmodium berghei-infected mice., Malaria is one of the most lethal infectious diseases in tropical regions. Among the five protozoan species of Plasmodium that infect humans, P. falciparum parasites cause the highest and most [...]

Forced displacement – the involuntary movement of people from their homes and livelihoods – has captured public attention through diverging discourses of humanitarianism and global xenophobia. 2.5 million asylum claims were lodged in the European Union (EU) in 2015–16 leading to national and region-wide strategies of border securitization. Refugee governance in the EU is marked by contradictory ideological positions where liberal humanitarianism, through refugee acceptance, dovetails with racial violence evidenced by ongoing detention and circuitous displacement. These divergent positions, and their resultant policies of refugee management, avoid the social reality of neoliberalisation as it pertains to widespread homelessness and work-related insecurity in major EU cities such as Paris. This disavowal occurs in a raced market and impedes the survival of refugees through insistence on self-reliance – a disciplinary logic endemic to neoliberalism and imposed on refugees upon relocation. I argue that self-reliance transforms refugees into disposable subjects in capitalism at various stages of the asylum process from escape and detention to relocation and ongoing displacement. [ABSTRACT FROM AUTHOR]