200 results on '"Asevedo, Elson"'
Search Results
2. Metabolomics and lipidomics analyses by 1H nuclear magnetic resonance of schizophrenia patient serum reveal potential peripheral biomarkers for diagnosis
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Tasic, Ljubica, Pontes, João G.M., Carvalho, Michelle S., Cruz, Guilherme, Dal Mas, Carolines, Sethi, Sumit, Pedrini, Mariana, Rizzo, Lucas B., Zeni-Graiff, Maiara, Asevedo, Elson, Lacerda, Acioly L.T., Bressan, Rodrigo A., Poppi, Ronei Jesus, Brietzke, Elisa, and Hayashi, Mirian A.F.
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- 2017
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3. 1H-NMR, 1H-NMR T2-edited, and 2D-NMR in bipolar disorder metabolic profiling
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Sethi, Sumit, Pedrini, Mariana, Rizzo, Lucas B., Zeni-Graiff, Maiara, Mas, Caroline Dal, Cassinelli, Ana Cláudia, Noto, Mariane N., Asevedo, Elson, Cordeiro, Quirino, Pontes, João G. M., Brasil, Antonio J. M., Lacerda, Acioly, Hayashi, Mirian A. F., Poppi, Ronei, Tasic, Ljubica, and Brietzke, Elisa
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- 2017
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4. Peripheral immuno-inflammatory abnormalities in ultra-high risk of developing psychosis
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Zeni-Graiff, Maiara, Rizzo, Lucas B., Mansur, Rodrigo B., Maurya, Pawan K., Sethi, Sumit, Cunha, Graccielle R., Asevedo, Elson, Pan, Pedro, Zugman, André, Yamagata, Ana S., Higuchi, Cinthia, Bressan, Rodrigo A., Gadelha, Ary, and Brietzke, Elisa
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- 2016
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5. Bipolar disorder course, impaired glucose metabolism and antioxidant enzymes activities: A preliminary report
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Mansur, Rodrigo B., Rizzo, Lucas B., Santos, Camila M., Asevedo, Elson, Cunha, Graccielle R., Noto, Mariane N., Pedrini, Mariana, Zeni-Graiff, Maiara, Gouvea, Eduardo S., Cordeiro, Quirino, Reininghaus, Eva Z., McIntyre, Roger S., and Brietzke, Elisa
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- 2016
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6. Association of serum interleukin-6 with mental health problems in children exposed to perinatal complications and social disadvantage
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Mansur, Rodrigo B., Cunha, Graccielle R., Asevedo, Elson, Zugman, André, Rizzo, Lucas B., Grassi-Oliveira, Rodrigo, Levandowski, Mateus L., Gadelha, Ary, Pan, Pedro M., Teixeira, Antônio L., McIntyre, Roger S., Mari, Jair J., Rohde, Luís A., Miguel, Eurípedes C., Bressan, Rodrigo A., and Brietzke, Elisa
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- 2016
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7. Impaired glucose metabolism moderates the course of illness in bipolar disorder
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Mansur, Rodrigo B., Rizzo, Lucas B., Santos, Camila M., Asevedo, Elson, Cunha, Graccielle R., Noto, Mariane N., Pedrini, Mariana, Zeni, Maiara, Cordeiro, Quirino, McIntyre, Roger S., and Brietzke, Elisa
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- 2016
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8. Adipokines, metabolic dysfunction and illness course in bipolar disorder
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Mansur, Rodrigo B., Rizzo, Lucas B., Santos, Camila M., Asevedo, Elson, Cunha, Graccielle R., Noto, Mariane N., Pedrini, Mariana, Zeni, Maiara, Cordeiro, Quirino, McIntyre, Roger S., and Brietzke, Elisa
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- 2016
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9. Adaptation to Brazilian Portuguese and Latin-American Spanish and psychometric properties of the Mental Illness Clinicians’ Attitudes Scale (MICA v4)
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Rojas Vistorte, Angel O., Ribeiro, Wagner, Ziebold, Carolina, Asevedo, Elson, Evans-Lacko, Sara, Varas, Denisse Jaen, Gutierrez, Nataly, Haddad, Michel, Ulloa, Oscar, Martínez, Ricel, Harada, Andresa Sartor, and Mari, Jair de Jesus
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BF Psychology ,RA0421 Public health. Hygiene. Preventive Medicine ,RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry - Abstract
Objective: To describe translation to Spanish and Portuguese and adaptation of the Mental Illness Clinicians’ Attitudes Scale version 4 (MICA v4). Methods: The questionnaire was administered to primary care physicians (PCPs) from four Latin- American countries, Brazil, Bolivia, Chile, and Cuba. The validation process included four phases: 1) translation of the questionnaire to Spanish and Portuguese; 2) assessment of face validity; 3) assessment of reliability; and 4) evaluation of construct validity with confirmatory factor analysis (CFA). Results: The study sample comprised 427 PCPs. The mean age of the Spanish-speaking sample (n =252) was 40.1 (S.D = 9.7) years and the mean age of the Portuguese-speaking sample (n = 150) was 40.2 (S.D = 10.9) years. Both models demonstrated “appropriate” internal reliability. Total omega was 0.91 for the Spanish-speaking sample and 0.89 for the Portuguese-speaking sample. The CFA of both questionnaires showed an appropriate fit for a three-factor model (Portuguese: CFI = 0.927; TLI = 0.913; RMSEA = 0.066; Spanish: CFI = 0.945; TLI = 0.935; RMSEA = 0.068). Conclusion: The Latin-American versions of the MICA v4 in Spanish and Brazilian Portuguese have appropriate psychometric properties, good internal consistency, and are applicable to and acceptable in the Latin-American context. The instrument proved its validity for collecting data on stigmatizing attitudes among health professionals in different contexts and cultures.
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- 2023
10. Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis
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Ong, Hui Lin, Isvoranu, Adela-Maria, Schirmbeck, Frederike, McGuire, Philip, Valmaggia, Lucia, Kempton, Matthew J., van der Gaag, Mark, Riecher-Rössler, Anita, Bressan, Rodrigo A., Barrantes-Vidal, Neus, Nelson, Barnaby, Amminger, G. Paul, McGorry, Patrick, Pantelis, Christos, Krebs, Marie-Odile, Nordentoft, Merete, Glenthøj, Birte, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P. F., van Os, Jim, de Haan, Lieuwe, Borsboom, Denny, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Pisani, Sara, Hedges, Emily, Velthorst, Eva, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Studerus, Erich, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Domínguez-Martínez, Tecelli, Monsonet, Manel, Hinojosa, Lidia, Racioppi, Anna, Kwapil, Thomas R., Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, C. lia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthøj, Louise Birkedal, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A., University of Amsterdam [Amsterdam] (UvA), Arkin Institute for Mental Health [Amsterdam, The Netherlands] (AIMH), King‘s College London, Vrije Universiteit Amsterdam [Amsterdam] (VU), Universitätsspital Basel [Switzerland], Universidade Federal de São Paulo, Universitat Autònoma de Barcelona (UAB), Centro de Investigación Biomédica en Red Salud Mental [Madrid] (CIBER-SAM), University of Melbourne, Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), University of Copenhagen = Københavns Universitet (KU), University of Cologne, Medizinische Universität Wien = Medical University of Vienna, Maastricht University Medical Centre (MUMC), Maastricht University [Maastricht], Utrecht University [Utrecht], EU-GEI High Risk Study: Maria Calem, Stefania Tognin, Gemma Modinos, Sara Pisani, Emily Hedges, Eva Velthorst, Tamar C Kraan, Daniella S van Dam, Nadine Burger, Athena Politis, Joanne Goodall, Stefan Borgwardt, Erich Studerus, Ary Gadelha, Elisa Brietzke, Graccielle Asevedo, Elson Asevedo, Andre Zugman, Tecelli Domínguez-Martínez, Manel Monsonet, Lidia Hinojosa, Anna Racioppi, Thomas R Kwapil, Mathilde Kazes, Claire Daban, Julie Bourgin, Olivier Gay, Célia Mam-Lam-Fook, Dorte Nordholm, Lasse Randers, Kristine Krakauer, Louise Birkedal Glenthøj, Dominika Gebhard, Julia Arnhold, Joachim Klosterkötter, Iris Lasser, Bernadette Winklbaur, Philippe A Delespaul, Adult Psychiatry, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, ANS - Complex Trait Genetics, Psychologische Methodenleer (Psychologie, FMG), Clinical Psychology, RS: MHeNs - R3 - Neuroscience, Psychiatrie & Neuropsychologie, MUMC+: MA Psychiatrie (3), RS: MHeNs - R2 - Mental Health, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), University of Copenhagen = Københavns Universitet (UCPH), and Martinez Rico, Clara
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Male ,DISORDER ,Obsessive-Compulsive Disorder ,Ultra-high risk ,obsessive-compulsive ,Psychological intervention ,clinical high risk ,Anxiety ,0302 clinical medicine ,SCHIZOPHRENIA ,COMPREHENSIVE ASSESSMENT ,psychosis ,Social isolation ,network analysis ,Depression (differential diagnoses) ,ASSOCIATIONS ,Psychiatry ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,Obsessive-compulsive ,Depression ,Clinical high risk ,anxiety ,CHILDHOOD TRAUMA ,Psychiatry and Mental health ,Schizophrenia ,depression ,Blunted Affect ,Female ,Network analysis ,medicine.symptom ,Life Sciences & Biomedicine ,Clinical psychology ,Adult ,Psychosis ,AcademicSubjects/MED00810 ,Risk Assessment ,ultra-high risk ,03 medical and health sciences ,Young Adult ,medicine ,Humans ,METAANALYSIS ,VULNERABILITY ,SPECTRUM ,Science & Technology ,business.industry ,At risk mental state ,medicine.disease ,030227 psychiatry ,INDIVIDUALS ,Psychotic Disorders ,Case-Control Studies ,business ,030217 neurology & neurosurgery ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Regular Articles - Abstract
Background The high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms of the at risk mental state for psychosis as assessed with the Comprehensive Assessment of At Risk Mental States (CAARMS) has not yet been investigated. This article aimed to use a network approach to investigate the associations between OCS and CAARMS symptoms in a large sample of individuals with different levels of risk for psychosis. Method Three hundred and forty-one UHR and 66 healthy participants were included, who participated in the EU-GEI study. Data analysis consisted of constructing a network of CAARMS symptoms, investigating central items in the network, and identifying the shortest pathways between OCS and positive symptoms. Results Strong associations between OCS and anxiety, social isolation and blunted affect were identified. Depression was the most central symptom in terms of the number of connections, and anxiety was a key item in bridging OCS to other symptoms. Shortest paths between OCS and positive symptoms revealed that unusual thought content and perceptual abnormalities were connected mainly via anxiety, while disorganized speech was connected via blunted affect and cognitive change. Conclusions Findings provide valuable insight into the central role of depression and the potential connective component of anxiety between OCS and other symptoms of the network. Interventions specifically aimed to reduce affective symptoms might be crucial for the development and prospective course of symptom co-occurrence.
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- 2021
11. Abnormalities in sleep patterns in individuals at risk for psychosis and bipolar disorder
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Zanini, Marcio A., Castro, Juliana, Cunha, Graccielle R., Asevedo, Elson, Pan, Pedro M., Bittencourt, Lia, Coelho, Fernando Morgadinho, Tufik, Sergio, Gadelha, Ary, Bressan, Rodrigo A., and Brietzke, Elisa
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- 2015
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12. Adaptation to Brazilian Portuguese and Latin-American Spanish and psychometric properties of the Mental Illness Clinicians’ Attitudes Scale (MICA v4)
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Vistorte, Angel O. Rojas, primary, Ribeiro, Wagner, additional, Ziebold, Carolina, additional, Asevedo, Elson, additional, Evans-Lacko, Sara, additional, Varas, Denisse Jaen, additional, Gutierrez, Nataly, additional, Haddad, Michel, additional, Ulloa, Oscar, additional, Martínez, Ricel, additional, Harada, Andresa Sartor, additional, and Mari, Jair de Jesus, additional
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- 2023
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13. Perinatal complications, lipid peroxidation, and mental health problems in a large community pediatric sample
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Mansur, Rodrigo B., Cunha, Graccielle R., Asevedo, Elson, Zugman, André, Rios, Adiel C., Salum, Giovanni A., Pan, Pedro M., Gadelha, Ary, Levandowski, Mateus L., Belangero, Síntia I., Manfro, Gisele G., Stertz, Laura, Kauer-Sant’anna, Márcia, Miguel, Eurípedes C., Bressan, Rodrigo A., Mari, Jair J., Grassi-Oliveira, Rodrigo, and Brietzke, Elisa
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- 2017
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14. Maconha e esquizofrenia
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Asevedo, Elson de Miranda, primary and Leite, Verônica da Silveira, additional
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- 2022
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15. Impact of peripheral levels of chemokines, BDNF and oxidative markers on cognition in individuals with schizophrenia
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Asevedo, Elson, Gadelha, Ary, Noto, Cristiano, Mansur, Rodrigo B., Zugman, André, Belangero, Síntia I.N., Berberian, Arthur A., Scarpato, Bruno S., Leclerc, Emilie, Teixeira, Antônio L., Gama, Clarissa S., Bressan, Rodrigo A., and Brietzke, Elisa
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- 2013
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16. Selfish brain and neuroprogression in bipolar disorder
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Mansur, Rodrigo B., Cha, Danielle S., Asevedo, Elson, McIntyre, Roger S., and Brietzke, Elisa
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- 2013
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17. The Relationship Between Grey Matter Volume and Clinical and Functional Outcomes in People at Clinical High Risk for Psychosis
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Tognin, Stefania, Richter, Anja, Kempton, Matthew J., Modinos, Gemma, Antoniades, Mathilde, Azis, Matilda, Allen, Paul, Bossong, Matthijs G., Perez, Jesus, Pantelis, Christos, Nelson, Barnaby, Amminger, Paul, Riecher-Rössler, Anita, Barrantes-Vidal, Neus, Krebs, Marie Odile, Glenthøj, Birte, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P., De Haan, Lieuwe, Van Der Gaag, Mark, Mcguire, Philip, Valmaggia, Lucia R., Calem, Maria, Pisani, Sara, Velthorst, Eva, Kraan, Tamar C., Van Dam, Daniella S., Burger, Nadine, Mcgorry, Patrick, Amminger, G. Paul, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Studerus, Erich, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Domínguez-Martínez, Tecelli, Racciopi, Anna, Kwapil, Thomas R., Monsonet, Manel, Hinojosa, Lídia, Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthøj, Louise, Nordentoft, Merete, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Aschauer, Harald, Delespaul, Philippe A., Van Os, Jim, Tognin, Stefania, Richter, Anja, Kempton, Matthew J., Modinos, Gemma, Antoniades, Mathilde, Azis, Matilda, Allen, Paul, Bossong, Matthijs G., Perez, Jesus, Pantelis, Christos, Nelson, Barnaby, Amminger, Paul, Riecher-Rössler, Anita, Barrantes-Vidal, Neus, Krebs, Marie Odile, Glenthøj, Birte, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P., De Haan, Lieuwe, Van Der Gaag, Mark, Mcguire, Philip, Valmaggia, Lucia R., Calem, Maria, Pisani, Sara, Velthorst, Eva, Kraan, Tamar C., Van Dam, Daniella S., Burger, Nadine, Mcgorry, Patrick, Amminger, G. Paul, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Studerus, Erich, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Domínguez-Martínez, Tecelli, Racciopi, Anna, Kwapil, Thomas R., Monsonet, Manel, Hinojosa, Lídia, Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthøj, Louise, Nordentoft, Merete, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Aschauer, Harald, Delespaul, Philippe A., and Van Os, Jim
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Objective: To examine the association between baseline alterations in grey matter volume (GMV) and clinical and functional outcomes in people at clinical high risk (CHR) for psychosis. Methods: 265 CHR individuals and 92 healthy controls were recruited as part of a prospective multi-center study. After a baseline assessment using magnetic resonance imaging (MRI), participants were followed for at least two years to determine clinical and functional outcomes, including transition to psychosis (according to the Comprehensive Assessment of an At Risk Mental State, CAARMS), level of functioning (according to the Global Assessment of Functioning), and symptomatic remission (according to the CAARMS). GMV was measured in selected cortical and subcortical regions of interest (ROI) based on previous studies (ie orbitofrontal gyrus, cingulate gyrus, gyrus rectus, inferior temporal gyrus, parahippocampal gyrus, striatum, and hippocampus). Using voxel-based morphometry, we analysed the relationship between GMV and clinical and functional outcomes. Results: Within the CHR sample, a poor functional outcome (GAF < 65) was associated with relatively lower GMV in the right striatum at baseline (P <. 047 after Family Wise Error correction). There were no significant associations between baseline GMV and either subsequent remission or transition to psychosis. Conclusions: In CHR individuals, lower striatal GMV was associated with a poor level of overall functioning at follow-up. This finding was not related to effects of antipsychotic or antidepressant medication. The failure to replicate previous associations between GMV and later psychosis onset, despite studying a relatively large sample, is consistent with the findings of recent large-scale multi-center studies.
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- 2022
18. Plasma copeptin and metabolic dysfunction in individuals with bipolar disorder
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Mansur, Rodrigo B., Rizzo, Lucas B., Santos, Camila M., Asevedo, Elson, Cunha, Graccielle R., Noto, Mariane N., Pedrini, Mariana, Zeni‐Graiff, Maiara, Cordeiro, Quirino, McIntyre, Roger S., and Brietzke, Elisa
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- 2017
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19. Management of common mental disorders should take place in primary health or specialized care? Clinical decisions of psychiatrists from Latin American countries
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Haddad, Michel, primary, Vistorte, Angel O. Rojas, additional, Haddad, Glenda Guerra, additional, Ribeiro, Wagner, additional, Ziebold, Carolina, additional, Asevedo, Elson, additional, Evans-Lacko, Sara, additional, Ulloa, Oscar, additional, and Mari, Jair de Jesus, additional
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- 2022
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20. Clinical, cognitive and neuroanatomical associations of serum NMDAR autoantibodies in people at clinical high risk for psychosis
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Pollak, Thomas A, Kempton, Matthew J, Iyegbe, Conrad, Vincent, Angela, Irani, Sarosh R, Coutinho, Ester, Menassa, David A, Jacobson, Leslie, de Haan, Lieuwe, Ruhrmann, Stephan, Sachs, Gabriele, Riecher-Roessler, Anita, Krebs, Marie-Odile, Amminger, Paul, Glenthoj, Birte, Barrantes-Vidal, Neus, van Os, Jim, Rutten, Bart PF, Bressan, Rodrigo A, van der Gaag, Mark, Yolken, Robert, Hotopf, Matthew, Valmaggia, Lucia, Stone, James, David, Anthony S, McGuire, Philip, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Velthorst, Eva, Kraan, Tamar C, van Dam, Daniella S, Burger, Nadine, Nelson, Barnaby, McGorry, Patrick, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Rosa, Araceli, Racioppi, Anna, Monsonet, Manel, Hinojosa-Marques, Lidia, Kwapil, Thomas R, Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthoj, Louise, Nordentoft, Merete, Gebhard, Dominika, Arnhold, Julia, Klosterkoetter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A, Clinical Psychology, APH - Mental Health, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), MUMC+: Hersen en Zenuw Centrum (3), Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, Adult Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, and Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep
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Psychosis ,Biochemistry & Molecular Biology ,NEURONAL AUTOANTIBODIES ,Verbal learning ,Prognostic markers ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,ASPARTATE RECEPTOR AUTOANTIBODIES ,medicine ,1ST-EPISODE PSYCHOSIS ,LIMBIC ENCEPHALITIS ,RATING-SCALE ,BRAIN ,Molecular Biology ,Autoimmune disease ,Autoimmune encephalitis ,Psychiatry ,Science & Technology ,HIPPOCAMPAL ,business.industry ,Limbic encephalitis ,Case-control study ,Autoantibody ,Neurosciences ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,INDIVIDUALS ,nervous system ,Immunology ,ANTIBODIES ,Schizophrenia ,MENTAL STATE ,Neurosciences & Neurology ,business ,Life Sciences & Biomedicine ,030217 neurology & neurosurgery ,Neuroscience ,Psychopathology - Abstract
Serum neuronal autoantibodies, such as those to the NMDA receptor (NMDAR), are detectable in a subgroup of patients with psychotic disorders. It is not known if they are present before the onset of psychosis or whether they are associated with particular clinical features or outcomes. In a case–control study, sera from 254 subjects at clinical high risk (CHR) for psychosis and 116 healthy volunteers were tested for antibodies against multiple neuronal antigens implicated in CNS autoimmune disorders, using fixed and live cell-based assays (CBAs). Within the CHR group, the relationship between NMDAR antibodies and symptoms, cognitive function and clinical outcomes over 24 month follow-up was examined. CHR subjects were not more frequently seropositive for neuronal autoantibodies than controls (8.3% vs. 5.2%; OR = 1.50; 95% CI: 0.58–3.90). The NMDAR was the most common target antigen and NMDAR IgGs were more sensitively detected with live versus fixed CBAs (p p p p p
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- 2021
21. Stress reactivity as a putative mechanism linking childhood trauma with clinical outcomes in individuals at ultra-high-risk for psychosis: Findings from the EU-GEI High Risk Study
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Paetzold, I., Myin-Germeys, I., Schick, A., Nelson, B., Velthorst, Eva, Schirmbeck, F., Os, J., Morgan, C., Hartmann, J., van der Gaag, Mark, de Haan, Lieuwe, Valmaggia, Lucia R., McGuire, P., Kempton, Matthew J., Reininghaus, U., McGuire, Philip, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Kraan, Tamar C., Burger, Nadine, van Dam, Daniella S., Barrantes-Vidal, Neus, Domínguez-Martínez, Tecelli, Cristóbal-Narváez, Paula, Kwapil, Thomas R., Monsonet-Bardají, Manel, Hinojosa, Lídia, Riecher-Rössler, Anita, Borgwardt, Stefan, Rapp, Charlotte, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Ruhrmann, Stephan, Nordholm, Dorte, Randers, Lasse, Nordentoft, Merete, Pantelis, Christos, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), MUMC+: Hersen en Zenuw Centrum (3), Psychiatrie & Neuropsychologie, Adult Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, and Amsterdam Neuroscience - Complex Trait Genetics
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Experience sampling method ,Psychosis ,Experience sampling method (ESM) ,Epidemiology ,Ultra high risk ,At-risk mental state ,Affect (psychology) ,TRANSITION RATE ,Stress sensitization ,ECOLOGICAL MOMENTARY INTERVENTIONS ,Surveys and Questionnaires ,medicine ,Humans ,experience sampling method (ESM) ,EMOTIONAL REACTIVITY ,Ecological momentary assessment (EMA) ,Depression (differential diagnoses) ,METAANALYSIS ,Psychiatry ,Science & Technology ,Mechanism (biology) ,business.industry ,Childhood abuse ,BLACK-BOX ,Public Health, Environmental and Occupational Health ,childhood abuse ,transition ,EXPERIENCE SAMPLING RESEARCH ,At risk mental state ,medicine.disease ,DEPRESSION ,DAILY-LIFE STRESS ,Psychiatry and Mental health ,Psychotic Disorders ,Transition ,at-risk mental state ,stress sensitization ,ecological momentary assessment (EMA) ,SCHIZOPHRENIA SPECTRUM DISORDERS ,Original Article ,Self Report ,SENSITIVITY ,Stress reactivity ,business ,Life Sciences & Biomedicine ,Stress, Psychological ,Clinical psychology - Abstract
Aims Childhood trauma is associated with an elevated risk for psychosis, but the psychological mechanisms involved remain largely unclear. This study aimed to investigate emotional and psychotic stress reactivity in daily life as a putative mechanism linking childhood trauma and clinical outcomes in individuals at ultra-high-risk (UHR) for psychosis. Methods Experience sampling methodology was used to measure momentary stress, affect and psychotic experiences in the daily life of N = 79 UHR individuals in the EU-GEI High Risk Study. The Childhood Trauma Questionnaire was used to assess self-reported childhood trauma. Clinical outcomes were assessed at baseline, 1- and 2-year follow-up. Results The association of stress with positive (β = −0.14, p = 0.010) and negative affect (β = 0.11, p = 0.020) was modified by transition status such that stress reactivity was greater in individuals who transitioned to psychosis. Moreover, the association of stress with negative affect (β = 0.06, p = 0.019) and psychotic experiences (β = 0.05, p = 0.037) was greater in individuals exposed to high v. low levels of childhood trauma. We also found evidence that decreased positive affect in response to stress was associated with reduced functioning at 1-year follow-up (B = 6.29, p = 0.034). In addition, there was evidence that the association of childhood trauma with poor functional outcomes was mediated by stress reactivity (e.g. indirect effect: B = −2.13, p = 0.026), but no evidence that stress reactivity mediated the association between childhood trauma and transition (e.g. indirect effect: B = 0.14, p = 0.506). Conclusions Emotional and psychotic stress reactivity may be potential mechanisms linking childhood trauma with clinical outcomes in UHR individuals.
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- 2021
22. Pre-training inter-rater reliability of clinical instruments in an international psychosis research project
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Calem, Maria, Tognin, Stefania, Modinos, Gemma, Pisani, Sara, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, McGorry, Patrick, Amminger, G. Paul, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Studerus, Erich, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Domínguez-Martínez, Tecelli, Monsonet, Manel, Hinojosa, Lidia, Cristóbal-Narváez, Paula, Racioppi, Anna, Kwapil, Thomas R., Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Célia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthøj, Louise Birkedal, Glenthøj, Birte, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A., Berendsen, Steven, Kapitein, Pim, Schirmbeck, Frederike, van Tricht, Mirjam J., McGuire, Philip, Morgan, Craig, Gayer-Anderson, Charlotte, Kempton, Matthew J., Valmaggia, Lucia, Quattrone, Diego, di Forti, Marta, van der Gaag, Mark, Kirkbride, James B., Jongsma, Hannah E., Jones, Peter B., Parellada, Maria, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Sanjuán, Julio, Santos, José Luis, Szöke, Andrei, Tortelli, Andrea, Llorca, Pierre-Michel, Tarricone, Ilaria, Tripoli, Giada, Ferraro, Laura, La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Nelson, Barnaby, Riecher-Rössler, Anita, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P.F., van Os, Jim, Velthorst, Eva, and de Haan, Lieuwe
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- 2021
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23. Clinical, cognitive and neuroanatomical associations of serum NMDAR autoantibodies in people at clinical high risk for psychosis
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Pollak, Thomas A., Kempton, Matthew J., Iyegbe, Conrad, Vincent, Angela, Irani, Sarosh R., Coutinho, Ester, Menassa, David A., Jacobson, Leslie, de Haan, Lieuwe, Ruhrmann, Stephan, Sachs, Gabriele, Riecher-Rössler, Anita, Krebs, Marie Odile, Amminger, Paul, Glenthøj, Birte, Barrantes-Vidal, Neus, van Os, Jim, Rutten, Bart P.F., Bressan, Rodrigo A., van der Gaag, Mark, Yolken, Robert, Hotopf, Matthew, Valmaggia, Lucia, Stone, James, David, Anthony S., Calem, Maria, Tognin, Stefania, Modinos, Gemma, Velthorst, Eva, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, Nelson, Barnaby, McGorry, Patrick, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Nordholm, Dorte, Randers, Lasse, Nordentoft, Merete, Pollak, Thomas A., Kempton, Matthew J., Iyegbe, Conrad, Vincent, Angela, Irani, Sarosh R., Coutinho, Ester, Menassa, David A., Jacobson, Leslie, de Haan, Lieuwe, Ruhrmann, Stephan, Sachs, Gabriele, Riecher-Rössler, Anita, Krebs, Marie Odile, Amminger, Paul, Glenthøj, Birte, Barrantes-Vidal, Neus, van Os, Jim, Rutten, Bart P.F., Bressan, Rodrigo A., van der Gaag, Mark, Yolken, Robert, Hotopf, Matthew, Valmaggia, Lucia, Stone, James, David, Anthony S., Calem, Maria, Tognin, Stefania, Modinos, Gemma, Velthorst, Eva, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, Nelson, Barnaby, McGorry, Patrick, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Nordholm, Dorte, Randers, Lasse, and Nordentoft, Merete
- Abstract
Serum neuronal autoantibodies, such as those to the NMDA receptor (NMDAR), are detectable in a subgroup of patients with psychotic disorders. It is not known if they are present before the onset of psychosis or whether they are associated with particular clinical features or outcomes. In a case–control study, sera from 254 subjects at clinical high risk (CHR) for psychosis and 116 healthy volunteers were tested for antibodies against multiple neuronal antigens implicated in CNS autoimmune disorders, using fixed and live cell-based assays (CBAs). Within the CHR group, the relationship between NMDAR antibodies and symptoms, cognitive function and clinical outcomes over 24 month follow-up was examined. CHR subjects were not more frequently seropositive for neuronal autoantibodies than controls (8.3% vs. 5.2%; OR = 1.50; 95% CI: 0.58–3.90). The NMDAR was the most common target antigen and NMDAR IgGs were more sensitively detected with live versus fixed CBAs (p < 0.001). Preliminary phenotypic analyses revealed that within the CHR sample, the NMDAR antibody seropositive subjects had higher levels of current depression, performed worse on the Rey Auditory Verbal Learning Task (p < 0.05), and had a markedly lower IQ (p < 0.01). NMDAR IgGs were not more frequent in subjects who later became psychotic than those who did not. NMDAR antibody serostatus and titre was associated with poorer levels of functioning at follow-up (p < 0.05) and the presence of a neuronal autoantibody was associated with larger amygdala volumes (p < 0.05). Altogether, these findings demonstrate that NMDAR autoantibodies are detectable in a subgroup of CHR subjects at equal rates to controls. In the CHR group, they are associated with affective psychopathology, impairments in verbal memory, and overall cognitive function: these findings are qualitatively and individually similar to core features of autoimmune encephalitis and/or animal models of NMDAR antibody-mediated CNS disease. Ov
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- 2021
24. Pre-training inter-rater reliability of clinical instruments in an international psychosis research project
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Berendsen, Steven, primary, Kapitein, Pim, additional, Schirmbeck, Frederike, additional, van Tricht, Mirjam J., additional, McGuire, Philip, additional, Morgan, Craig, additional, Gayer-Anderson, Charlotte, additional, Kempton, Matthew J., additional, Valmaggia, Lucia, additional, Quattrone, Diego, additional, di Forti, Marta, additional, van der Gaag, Mark, additional, Kirkbride, James B., additional, Jongsma, Hannah E., additional, Jones, Peter B., additional, Parellada, Maria, additional, Arango, Celso, additional, Arrojo, Manuel, additional, Bernardo, Miguel, additional, Sanjuán, Julio, additional, Santos, José Luis, additional, Szöke, Andrei, additional, Tortelli, Andrea, additional, Llorca, Pierre-Michel, additional, Tarricone, Ilaria, additional, Tripoli, Giada, additional, Ferraro, Laura, additional, La Cascia, Caterina, additional, Lasalvia, Antonio, additional, Tosato, Sarah, additional, Menezes, Paulo Rossi, additional, Del-Ben, Cristina Marta, additional, Nelson, Barnaby, additional, Riecher-Rössler, Anita, additional, Bressan, Rodrigo, additional, Barrantes-Vidal, Neus, additional, Krebs, Marie-Odile, additional, Nordentoft, Merete, additional, Ruhrmann, Stephan, additional, Sachs, Gabriele, additional, Rutten, Bart P.F., additional, van Os, Jim, additional, Velthorst, Eva, additional, de Haan, Lieuwe, additional, Calem, Maria, additional, Tognin, Stefania, additional, Modinos, Gemma, additional, Pisani, Sara, additional, Kraan, Tamar C., additional, van Dam, Daniella S., additional, Burger, Nadine, additional, McGorry, Patrick, additional, Amminger, G. Paul, additional, Politis, Athena, additional, Goodall, Joanne, additional, Borgwardt, Stefan, additional, Studerus, Erich, additional, Gadelha, Ary, additional, Brietzke, Elisa, additional, Asevedo, Graccielle, additional, Asevedo, Elson, additional, Zugman, Andre, additional, Domínguez-Martínez, Tecelli, additional, Monsonet, Manel, additional, Hinojosa, Lidia, additional, Cristóbal-Narváez, Paula, additional, Racioppi, Anna, additional, Kwapil, Thomas R., additional, Kazes, Mathilde, additional, Daban, Claire, additional, Bourgin, Julie, additional, Gay, Olivier, additional, Mam-Lam-Fook, Célia, additional, Nordholm, Dorte, additional, Randers, Lasse, additional, Krakauer, Kristine, additional, Glenthøj, Louise Birkedal, additional, Glenthøj, Birte, additional, Gebhard, Dominika, additional, Arnhold, Julia, additional, Klosterkötter, Joachim, additional, Lasser, Iris, additional, Winklbaur, Bernadette, additional, and Delespaul, Philippe A., additional
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- 2021
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25. Dysregulated Lipid Metabolism Precedes Onset of Psychosis
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Dickens, Alex M., primary, Sen, Partho, additional, Kempton, Matthew J., additional, Barrantes-Vidal, Neus, additional, Iyegbe, Conrad, additional, Nordentoft, Merete, additional, Pollak, Thomas, additional, Riecher-Rössler, Anita, additional, Ruhrmann, Stephan, additional, Sachs, Gabriele, additional, Bressan, Rodrigo, additional, Krebs, Marie-Odile, additional, Amminger, G. Paul, additional, de Haan, Lieuwe, additional, van der Gaag, Mark, additional, Valmaggia, Lucia, additional, Hyötyläinen, Tuulia, additional, Orešič, Matej, additional, McGuire, Philip, additional, Valmaggia, Lucia R., additional, Calem, Maria, additional, Tognin, Stefania, additional, Modinos, Gemma, additional, Velthorst, Eva, additional, Kraan, Tamar C., additional, van Dam, Daniella S., additional, Burger, Nadine, additional, Nelson, Barnaby, additional, McGorry, Patrick, additional, Pantelis, Christos, additional, Politis, Athena, additional, Goodall, Joanne, additional, Borgwardt, Stefan, additional, Rapp, Charlotte, additional, Ittig, Sarah, additional, Studerus, Erich, additional, Smieskova, Renata, additional, Gadelha, Ary, additional, Brietzke, Elisa, additional, Asevedo, Graccielle, additional, Asevedo, Elson, additional, Zugman, Andre, additional, Domínguez-Martínez, Tecelli, additional, Racciopi, Anna, additional, Kwapil, Thomas R., additional, Monsonet, Manel, additional, Rosa, Araceli, additional, Frajerman, Ariel, additional, Chaumette, Boris, additional, Bourgin, Julie, additional, Kebir, Oussama, additional, Jantac, Célia, additional, Nordholm, Dorte, additional, Randers, Lasse, additional, Krakauer, Kristine, additional, Glenthøj, Louise, additional, Glenthøj, Birte, additional, Gebhard, Dominika, additional, Arnhold, Julia, additional, Klosterkötter, Joachim, additional, Lasser, Iris, additional, Winklbaur, Bernadette, additional, Delespaul, Philippe A., additional, Rutten, Bart P., additional, and van Os, Jim, additional
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- 2021
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26. From Speech Illusions to Onset of Psychotic Disorder: Applying Network Analysis to an Experimental Measure of Aberrant Experiences
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Boyette, Lindy-Lou, Isvoranu, Adela-Maria, Schirmbeck, Frederike, Velthorst, Eva, Simons, Claudia J P, Barrantes-Vidal, Neus, Bressan, Rodrigo, Kempton, Matthew J, Krebs, Marie-Odile, McGuire, Philip, Nelson, Barnaby, Nordentoft, Merete, Riecher-Rössler, Anita, Ruhrmann, Stephan, Rutten, Bart P, Sachs, Gabriele, Valmaggia, Lucia R, van der Gaag, Mark, Borsboom, Denny, de Haan, Lieuwe, van Os, Jim, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Kraan, Tamar C, van Dam, Daniella S, Burger, Nadine, McGorry, Patrick, Amminger, G Paul, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Studerus, Erich, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Domínguez-Martínez, Tecelli, Cristóbal-Narváez, Paula, Kwapil, Thomas R, Monsonet, Manel, Hinojosa, Lídia, Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Célia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthøj, Louise, Glenthøj, Birte, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A, Klinische Psychologie (Psychologie, FMG), and Psychologische Methodenleer (Psychologie, FMG)
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Psychosis ,media_common.quotation_subject ,Illusion ,Network structure ,Ideation ,Affect (psychology) ,medicine.disease ,030227 psychiatry ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,medicine ,In patient ,Psychology ,030217 neurology & neurosurgery ,Depression (differential diagnoses) ,Network approach ,Clinical psychology ,media_common - Abstract
Aberrant perceptional experiences are a potential early marker of psychosis development. Earlier studies have found experimentally assessed speech illusions to be associated with positive symptoms in patients with psychotic disorders, but findings for attenuated symptoms in individuals without psychotic disorders have been inconsistent. Also, the role of affect is unclear. The aim of this study was to use the network approach to investigate how speech illusions relate to individual symptoms and onset of a psychotic disorder. We estimated a network model based on data from 289 Clinical High-Risk (CHR) subjects, participating in the EU-GEI project. The network structure depicts statistical associations between (affective and all) speech illusions, cross-sectional individual attenuated positive and affective symptoms, and transition to psychotic disorder after conditioning on all other variables in the network. Speech illusions were assessed with the White Noise Task, symptoms with the BPRS and transition during 24-month follow-up with the CAARMS. Affective, not all, speech illusions were found to be directly, albeit weakly, associated with hallucinatory experiences. Hallucinatory experiences, in turn, were associated with delusional ideation. Bizarre behavior was the only symptom in the network steadily predictive of transition. Affective symptoms were highly interrelated, with depression showing the highest overall strength of connections to and predictability by other symptoms. Both speech illusions and transition showed low overall predictability by symptoms. Our findings suggest that experimentally assessed speech illusions are not a mere consequence of psychotic symptoms or disorder, but that their single assessment is likely not useful for assessing transition risk.
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- 2020
27. Association of Adverse Outcomes With Emotion Processing and Its Neural Substrate in Individuals at Clinical High Risk for Psychosis
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Modinos, Gemma, Kempton, Matthew J., Tognin, Stefania, Calem, Maria, Porffy, Lilla, Antoniades, Mathilde, Mason, Ava, Azis, Matilda, Allen, Paul, Nelson, Barnaby, McGorry, Patrick, Pantelis, Christos, Riecher-Rossler, Anita, Borgwardt, Stefan, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Glenthoj, Birte, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart, van Os, Jim, de Haan, Lieuwe, Velthorst, Eva, van der Gaag, Mark, Valmaggia, Lucia R., McGuire, Philip, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, Amminger, G. Paul, Politis, Athena, Goodall, Joanne, Rapp, Charlotte, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Dominguez-Martinez, Tecelli, Monsonet, Manel, Hinojosa, Lidia, Racioppi, Anna, Kwapil, Thomas R., Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthoj, Louise Birkedal, Gebhard, Dominika, Arnhold, Julia, Klosterkotter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A., Modinos, Gemma, Kempton, Matthew J., Tognin, Stefania, Calem, Maria, Porffy, Lilla, Antoniades, Mathilde, Mason, Ava, Azis, Matilda, Allen, Paul, Nelson, Barnaby, McGorry, Patrick, Pantelis, Christos, Riecher-Rossler, Anita, Borgwardt, Stefan, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Glenthoj, Birte, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart, van Os, Jim, de Haan, Lieuwe, Velthorst, Eva, van der Gaag, Mark, Valmaggia, Lucia R., McGuire, Philip, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, Amminger, G. Paul, Politis, Athena, Goodall, Joanne, Rapp, Charlotte, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Dominguez-Martinez, Tecelli, Monsonet, Manel, Hinojosa, Lidia, Racioppi, Anna, Kwapil, Thomas R., Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthoj, Louise Birkedal, Gebhard, Dominika, Arnhold, Julia, Klosterkotter, Joachim, Lasser, Iris, Winklbaur, Bernadette, and Delespaul, Philippe A.
- Abstract
This case-control study analyzes emotion recognition and neuroimaging data as well as clinical and functional outcomes for individuals at risk for transition to psychosis and those without psychiatric or neurological disorders. Question Is altered emotion recognition associated with adverse clinical and functional outcomes in people at clinical high risk for psychosis? Findings In this case-control study of 213 individuals at clinical high risk for psychosis and 52 healthy participants, abnormalities in the recognition of negative emotion at baseline were associated with neuroanatomical alterations in the medial prefrontal cortex and hippocampus and with a low level of functioning at a 12-month follow-up. Meaning This study found that, in people with high risk for developing psychosis, functional outcomes are associated with the degree to which their emotion processing is altered. Importance The development of adverse clinical outcomes in patients with psychosis has been associated with behavioral and neuroanatomical deficits related to emotion processing. However, the association between alterations in brain regions subserving emotion processing and clinical outcomes remains unclear. Objective To examine the association between alterations in emotion processing and regional gray matter volumes in individuals at clinical high risk (CHR) for psychosis, and the association with subsequent clinical outcomes. Design, Setting, and Participants This naturalistic case-control study with clinical follow-up at 12 months was conducted from July 1, 2010, to August 31, 2016, and collected data from 9 psychosis early detection centers (Amsterdam, Basel, Cologne, Copenhagen, London, Melbourne, Paris, The Hague, and Vienna). Participants (213 individuals at CHR and 52 healthy controls) were enrolled in the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) project. Data were analyzed from October 1, 2018, to April 24, 2019. Main Mea
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- 2020
28. Association of Adverse Outcomes With Emotion Processing and Its Neural Substrate in Individuals at Clinical High Risk for Psychosis
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Modinos, Gemma, Kempton, Matthew J, Tognin, Stefania, Calem, Maria, Porffy, Lilla, Antoniades, Mathilde, Mason, Ava, Azis, Matilda, Allen, Paul, Nelson, Barnaby, McGorry, Patrick, Pantelis, Christos, Riecher-Rossler, Anita, Borgwardt, Stefan, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Glenthoj, Birte, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart, van Os, Jim, de Haan, Lieuwe, Velthorst, Eva, van der Gaag, Mark, Valmaggia, Lucia R, McGuire, Philip, Kraan, Tamar C, van Dam, Daniella S, Burger, Nadine, Amminger, G Paul, Politis, Athena, Goodall, Joanne, Rapp, Charlotte, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Dominguez-Martinez, Tecelli, Monsonet, Manel, Hinojosa, Lidia, Racioppi, Anna, Kwapil, Thomas R, Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthoj, Louise Birkedal, Gebhard, Dominika, Arnhold, Julia, Klosterkotter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A, MUMC+: MA Psychiatrie (3), Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, RS: MHeNs - R2 - Mental Health, Adult Psychiatry, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, King‘s College London, University of Roehampton, United Kingdom, University of Melbourne, University of Copenhagen = Københavns Universitet (KU), University of Basel (Unibas), Universidade Federal de São Paulo-Escola Paulista de Medicina [Brazil] (UNIFESP-EPM), Universitat Autònoma de Barcelona (UAB), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), University of Cologne, Medizinische Universität Wien = Medical University of Vienna, Maastricht University [Maastricht], University Medical Center [Utrecht], Amsterdam UMC, Icahn School of Medicine at Mount Sinai [New York] (MSSM), Vrije Universiteit Amsterdam [Amsterdam] (VU), Parnassia Psychiatric Institute [The Hague], South London and Maudsley NHS Foundation Trust, EU-GEI High Risk Study Group, University of Copenhagen = Københavns Universitet (UCPH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Amsterdam UMC - Amsterdam University Medical Center, Martinez Rico, Clara, and Clinical Psychology
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Male ,Global Assessment of Functioning ,Emotions ,Psychological intervention ,FEARFUL FACES ,PREFRONTAL CORTEX ,0302 clinical medicine ,SCHIZOPHRENIA ,Young adult ,Gray Matter ,Emotional Intelligence ,Psychiatry ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,Socioemotional selectivity theory ,Brain ,Magnetic Resonance Imaging ,NEUTRAL FACES ,3. Good health ,Psychiatry and Mental health ,SOCIAL COGNITION ,Female ,Life Sciences & Biomedicine ,Facial Recognition ,Clinical psychology ,Psychosis ,longitudinal ,Bipolar disorder ,Neuroimaging ,functioning ,03 medical and health sciences ,Young Adult ,medicine ,trajectories ,Humans ,GRAY-MATTER VOLUME ,METAANALYSIS ,Psychiatric Status Rating Scales ,Science & Technology ,business.industry ,Case-control study ,RECOGNITION ,prediction ,medicine.disease ,030227 psychiatry ,Psychotic Disorders ,ULTRA-HIGH RISK ,Case-Control Studies ,ONSET ,business ,Insula ,030217 neurology & neurosurgery ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Ajuts: Project is funded by grant agreement HEALTH-F2-2010-241909 (Project EU-GEI) from the European Community Seventh Framework Programme. Additional financial support was obtained from the Institut National de la Santé et de la Recherche Médicale (recurrent funding and fellowships) and by Fondation Pierre Deniker. The study received grant 08-MNP-007 from the French government Agence Nationale de la Recherche and grant AOM-07-118 (Influence of Cannabis Psychopathological Outcome in At-risk Mental State [ICAAR study]) from the French Health Ministry Programme Hospitalier de Recherche Clinique. The Sainte-Anne Hospital Center promoted the study. Dr Kempton was supported by a Medical Research Council Fellowship grant MR/J008915/1. Dr Pantelis was supported by Australia's National Health and Medical Research Council Senior Principal Research Fellowship (ID: 628386 & 1105825) and by grant R246-2016-3237 from the Lundbeck Foundation. Dr Barrantes-Vidal was supported by the Ministerio de Ciencia, Innovación e Universidades (PSI2017-87512-C2-1-R), and the Generalitat de Catalunya (2017SGR1612 and ICREA Academia Award). Dr Modinos was supported by a Sir Henry Dale Fellowship #202397/Z/16/Z, jointly funded by The Wellcome Trust and the Royal Society. This case-control study analyzes emotion recognition and neuroimaging data as well as clinical and functional outcomes for individuals at risk for transition to psychosis and those without psychiatric or neurological disorders. Is altered emotion recognition associated with adverse clinical and functional outcomes in people at clinical high risk for psychosis? In this case-control study of 213 individuals at clinical high risk for psychosis and 52 healthy participants, abnormalities in the recognition of negative emotion at baseline were associated with neuroanatomical alterations in the medial prefrontal cortex and hippocampus and with a low level of functioning at a 12-month follow-up. This study found that, in people with high risk for developing psychosis, functional outcomes are associated with the degree to which their emotion processing is altered. The development of adverse clinical outcomes in patients with psychosis has been associated with behavioral and neuroanatomical deficits related to emotion processing. However, the association between alterations in brain regions subserving emotion processing and clinical outcomes remains unclear. To examine the association between alterations in emotion processing and regional gray matter volumes in individuals at clinical high risk (CHR) for psychosis, and the association with subsequent clinical outcomes. This naturalistic case-control study with clinical follow-up at 12 months was conducted from July 1, 2010, to August 31, 2016, and collected data from 9 psychosis early detection centers (Amsterdam, Basel, Cologne, Copenhagen, London, Melbourne, Paris, The Hague, and Vienna). Participants (213 individuals at CHR and 52 healthy controls) were enrolled in the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) project. Data were analyzed from October 1, 2018, to April 24, 2019. Emotion recognition was assessed with the Degraded Facial Affect Recognition Task. Three-Tesla magnetic resonance imaging scans were acquired from all participants, and gray matter volume was measured in regions of interest (medial prefrontal cortex, amygdala, hippocampus, and insula). Clinical outcomes at 12 months were evaluated for transition to psychosis using the Comprehensive Assessment of At-Risk Mental States criteria, and the level of overall functioning was measured through the Global Assessment of Functioning [GAF] scale. A total of 213 individuals at CHR (105 women [49.3%]; mean [SD] age, 22.9 [4.7] years) and 52 healthy controls (25 women [48.1%]; mean [SD] age, 23.3 [4.0] years) were included in the study at baseline. At the follow-up within 2 years of baseline, 44 individuals at CHR (20.7%) had developed psychosis and 169 (79.3%) had not. Of the individuals at CHR reinterviewed with the GAF, 39 (30.0%) showed good overall functioning (GAF score, ≥65), whereas 91 (70.0%) had poor overall functioning (GAF score
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- 2019
29. Cytokines in schizophrenia: Possible role of anti-inflammatory medications in clinical and preclinical stages
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Mansur, Rodrigo Barbachan, Zugman, André, de Miranda Asevedo, Elson, da Cunha, Graccielle Rodrigues, Bressan, Rodrigo Affonseca, and Brietzke, Elisa
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- 2012
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30. Continuing lack of evidence for the psychotic subtyping of PTSD
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Brietzke, Elisa, Zugman, André, Asevedo, Elson, Mansur, Rodrigo, and da Cunham, Graccielle Rodrigues
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- 2011
31. Population neuroscience: challenges and opportunities for psychiatric research in low- and middle-income countries
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Cirillo, Alessandra, primary, Diniz, Elton, additional, Gadelha, Ary, additional, Asevedo, Elson, additional, Axelrud, Luiza K., additional, Miguel, Eurípedes C., additional, Rohde, Luis Augusto, additional, Bressan, Rodrigo A., additional, Pan, Pedro, additional, and Mari, Jair de J., additional
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- 2020
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32. A 10-year ecological study of the methods of suicide used by Brazilian adolescents
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Jaen-Varas, Denisse Claudia, primary, Mari, Jair J., additional, Asevedo, Elson, additional, Borschmann, Rohan, additional, Diniz, Elton, additional, Ziebold, Carolina, additional, and Gadelha, Ary, additional
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- 2020
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33. O silêncio do suicídio em idosos
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Asevedo, Elson, primary
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- 2019
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34. Clinical utility of ICD-11 diagnostic guidelines for high-burden mental disorders: results from mental health settings in 13 countries
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Reed, Geoffrey M., Keeley, Jared W., Rebello, Tahilia J., First, Michael B., Gureje, Oye, Ayuso-Mateos, José Luis, Kanba, Shigenobu, Khoury, Brigitte, Kogan, Cary S., Krasnov, Valery N., Maj, Mario, de Jesus Mari, Jair, Sharan, Pratap, Stein, Dan J., Zhao, Min, Akiyama, Tsuyoshi, Andrews, Howard F., Asevedo, Elson, Cheour, Majda, Domínguez-Martínez, Tecelli, El-Khoury, Joseph, Fiorillo, Andrea, Grenier, Jean, Gupta, Nitin, Kola, Lola, Kulygina, Maya, Leal-Leturia, Itziar, Luciano, Mario, Lusu, Bulumko, Martínez-López, J. Nicolás I., Matsumoto, Chihiro, Odunleye, Mayokun, Onofa, Lucky Umukoro, Paterniti, Sabrina, Purnima, Shivani, Robles, Rebeca, Sahu, Manoj K., Sibeko, Goodman, Zhong, Na, Gaebel, Wolfgang, Lovell, Anne M., Maruta, Toshimasa, Pike, Kathleen M., Roberts, Michael C., Medina-Mora, María Elena, Reed, Geoffrey M., Keeley, Jared W., Rebello, Tahilia J., First, Michael B., Gureje, Oye, Ayuso-Mateos, José Lui, Kanba, Shigenobu, Khoury, Brigitte, Kogan, Cary S., Krasnov, Valery N., Maj, Mario, de Jesus Mari, Jair, Sharan, Pratap, Stein, Dan J., Zhao, Min, Akiyama, Tsuyoshi, Andrews, Howard F., Asevedo, Elson, Cheour, Majda, Domínguez-Martínez, Tecelli, El-Khoury, Joseph, Fiorillo, Andrea, Grenier, Jean, Gupta, Nitin, Kola, Lola, Kulygina, Maya, Leal-Leturia, Itziar, Luciano, Mario, Lusu, Bulumko, Martínez-López, J. Nicolás I., Matsumoto, Chihiro, Odunleye, Mayokun, Onofa, Lucky Umukoro, Paterniti, Sabrina, Purnima, Shivani, Robles, Rebeca, Sahu, Manoj K., Sibeko, Goodman, Zhong, Na, Gaebel, Wolfgang, Lovell, Anne M., Maruta, Toshimasa, Pike, Kathleen M., Roberts, Michael C., and Medina-Mora, María Elena
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mental disorder ,diagnosis ,treatment selection ,assessing prognosi ,clinical utility ,Research Reports ,assessing prognosis ,mental disorders ,diagnosi ,goodness of fit ,Psychiatry and Mental Health ,ICD-11 ,International Classification of Diseases ,International Classification of Disease ,Psychiatric Mental Health ,ease of use - Abstract
In this paper we report the clinical utility of the diagnostic guidelines for ICD-11 mental, behavioural and neurodevelopmental disorders as assessed by 339 clinicians in 1,806 patients in 28 mental health settings in 13 countries. Clinician raters applied the guidelines for schizophrenia and other primary psychotic disorders, mood disorders (depressive and bipolar disorders), anxiety and fear-related disorders, and disorders specifically associated with stress. Clinician ratings of the clinical utility of the proposed ICD-11 diagnostic guidelines were very positive overall. The guidelines were perceived as easy to use, corresponding accurately to patients’ presentations (i.e., goodness of fit), clear and understandable, providing an appropriate level of detail, taking about the same or less time than clinicians’ usual practice, and providing useful guidance about distinguishing disorder from normality and from other disorders. Clinicians evaluated the guidelines as less useful for treatment selection and assessing prognosis than for communicating with other health professionals, though the former ratings were still positive overall. Field studies that assess perceived clinical utility of the proposed ICD-11 diagnostic guidelines among their intended users have very important implications. Classification is the interface between health encounters and health information; if clinicians do not find that a new diagnostic system provides clinically useful information, they are unlikely to apply it consistently and faithfully. This would have a major impact on the validity of aggregated health encounter data used for health policy and decision making. Overall, the results of this study provide considerable reason to be optimistic about the perceived clinical utility of the ICD-11 among global clinicians.
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- 2018
35. Child Maltreatment and Clinical Outcome in Individuals at Ultra-High Risk for Psychosis in the EU-GEI High Risk Study
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Kraan, Tamar C., Velthorst, Eva, Themmen, Manouk, Valmaggia, Lucia, Kempton, Matthew J., McGuire, Phillip, Van Os, Jim, Rutten, Bart P.F., Smit, Filip, De Haan, Lieuwe, Van Der Gaag, Mark, McGuire, Philip, Valmaggia, Lucia R., Calem, Maria, Tognin, Stefania, Modinos, Gemma, Burger, Nadine, Van Dam, Daniella S., Barrantes-Vidal, Neus, Domínguez-Martínez, Tecelli, Cristóbal-Narváez, Paula, Kwapil, Thomas R., Monsonet-Bardají, Manel, Hinojosa, Lídia, Riecher-Rössler, Anita, Borgwardt, Stefan, Rapp, Charlotte, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Ruhrmann, Stephan, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Naumann, Tanya Louise, Glenthøj, Louise Birkedal, Nordentoft, Merete, De Hert, Marc, Van Winkel, Ruud, Nelson, Barnaby, McGorry, Patrick, Clinical Psychology, APH - Mental Health, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), MUMC+: Hersen en Zenuw Centrum (3), Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, Adult Psychiatry, and Epidemiology and Data Science
- Subjects
Male ,Child abuse ,INCREASES ,clinical outcome ,Poison control ,Stress Disorders, Post-Traumatic ,0302 clinical medicine ,Risk Factors ,SCHIZOPHRENIA ,Child Abuse ,psychosis ,Psychological abuse ,ultra high risk ,Adult Survivors of Child Abuse ,PSYCHOPATHOLOGY ,Justice and Strong Institutions ,Europe ,Psychiatry and Mental health ,Schizophrenia ,Panic Disorder ,Female ,Psychology ,TRANSITION ,Psychopathology ,Clinical psychology ,Adult ,medicine.medical_specialty ,Psychosis ,SDG 16 - Peace ,LIFE EVENTS ,Adolescent ,DISORDERS ,Young Adult ,03 medical and health sciences ,medicine ,Humans ,COHORT ,Risk factor ,Psychiatry ,METAANALYSIS ,Depressive Disorder ,Panic disorder ,SDG 16 - Peace, Justice and Strong Institutions ,Phobia, Social ,medicine.disease ,030227 psychiatry ,CONVERSION ,Psychotic Disorders ,child maltreatment ,TRAUMATIC EXPERIENCES ,030217 neurology & neurosurgery ,Regular Articles ,Follow-Up Studies - Abstract
Background: Child maltreatment has been associated with a wide range of mental disorders in adulthood. Whether child maltreatment is specifically associated with psychosis risk in individuals at ultra-high risk (UHR) for psychosis, or leads to a general vulnerability for overall psychopathology in the UHR stage remains unclear. The present study examines the association between child maltreatment and transition to psychosis and other mental disorders. Methods: The sample consisted of 259 UHR individuals from the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Participants were followed-up for 2 years to assess clinical outcome. Clinical outcome was assessed at 6 months, 12 months, and 24 months after baseline. Child maltreatment before the age of 17 years was assessed at baseline. Results: Our findings show that a history of emotional abuse was associated with an increased risk for transition to psychosis (OR = 3.78, 95% CI = 1.17 to 12.39, P = -027). Apart from psychosis, a history of physical abuse was associated with depressive disorder (OR = 4.92, 95% CI = 2.12 to 11.39, P = .001), post-traumatic stress disorder (OR = 2.06, 95% CI = 1.10 to 3.86, P = .023), panic disorder (OR = 2.00, 95% CI = 1.00 to 3.99, P = .048) and social phobia (OR = 2.47, 95% CI = 1.18 to 5.16, P = .016) at follow-up. Conclusion: Our findings suggest that in the UHR stage child maltreatment is a pluripotent risk factor for developing psychosis, depressive disorder, post-traumatic stress disorder (PTSD), panic disorder, and social phobia in adulthood.
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- 2017
36. Gender differences of patients at-risk for psychosis regarding symptomatology, drug use, comorbidity and functioning - Results from the EU-GEI study
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Menghini-Mueller, Stephanie, Studerus, Erich, Ittig, Sarah, Heitz, Ulrike, Egloff, Laura, Andreou, Christina, Valmaggia, Lucia R., Kempton, Matthew J., van der Gaag, Mark, de Haan, Lieuwe, Nelson, Barnaby, Barrantes-Vidal, Neus, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P., van Os, Jim, Riecher-Rossler, Anita, McGuire, Philip, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Velthorst, Eva, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, McGorry, Patrick, Amminger, G. Paul, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Rapp, Charlotte, Smieskova, Renata, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Dominguez-Martinez, Tecelli, Racioppi, Anna, Cristobal-Narvaez, Paula, Kwapil, Thomas R., Monsonet, Manel, Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Krebs, Marie-Odile, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthoj, Louise, Glenthoj, Birte, Gebhard, Dominika, Arnhold, Julia, Klosterkotter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespau, Philippe A., Menghini-Mueller, Stephanie, Studerus, Erich, Ittig, Sarah, Heitz, Ulrike, Egloff, Laura, Andreou, Christina, Valmaggia, Lucia R., Kempton, Matthew J., van der Gaag, Mark, de Haan, Lieuwe, Nelson, Barnaby, Barrantes-Vidal, Neus, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P., van Os, Jim, Riecher-Rossler, Anita, McGuire, Philip, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Velthorst, Eva, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, McGorry, Patrick, Amminger, G. Paul, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Rapp, Charlotte, Smieskova, Renata, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Dominguez-Martinez, Tecelli, Racioppi, Anna, Cristobal-Narvaez, Paula, Kwapil, Thomas R., Monsonet, Manel, Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Krebs, Marie-Odile, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthoj, Louise, Glenthoj, Birte, Gebhard, Dominika, Arnhold, Julia, Klosterkotter, Joachim, Lasser, Iris, Winklbaur, Bernadette, and Delespau, Philippe A.
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- 2019
37. The association between adolescent suicide rates and socioeconomic indicators in Brazil: a 10-year retrospective ecological study
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Jaen-Varas, Denisse, primary, Mari, Jair J., additional, Asevedo, Elson, additional, Borschmann, Rohan, additional, Diniz, Elton, additional, Ziebold, Carolina, additional, and Gadelha, Ary, additional
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- 2019
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38. Corrigendum to “Oxidative and nitrosative stress biomarkers in chronic schizophrenia”
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Boll, Karine Maria, primary, Noto, Cristiano, additional, Bonifácio, Kamila Landucci, additional, Bortolasci, Chiara Cristina, additional, Teixeira, Antonio Lucio, additional, Brietzke, Elisa, additional, Pedrini, Mariana, additional, Asevedo, Elson, additional, Gadelha, Ary, additional, Bressan, Rodrigo Affonseca, additional, Barbosa, Décio Sabbatini, additional, Maes, Michael, additional, and Moreira, Estefania Gastaldello, additional
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- 2019
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39. Clinical decisions and stigmatizing attitudes towards mental health problems in primary care physicians from Latin American countries
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Vistorte, Angel O. Rojas, primary, Ribeiro, Wagner, additional, Ziebold, Carolina, additional, Asevedo, Elson, additional, Evans-Lacko, Sara, additional, Keeley, Jared W., additional, Gonçalves, Daniel Almeida, additional, Palacios, Nataly Gutierrez, additional, and Mari, Jair de Jesus, additional
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- 2018
- Full Text
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40. Shorter leukocyte telomere length in patients at ultra high risk for psychosis
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Maurya, Pawan Kumar, Rizzo, Lucas Bortolotto, Xavier, Gabriela, Tempaku, Priscila Farias, Zeni-Graiff, Maiara, Santoro, Marcos L., Mazzotti, Diego Robles, Zugman, André, Pan, Pedro, Noto, Cristiano, Maes, Michael, Asevedo, Elson, Mansur, Rodrigo B., Cunha, Graccielle R., Gadelha, Ary, Bressan, Rodrigo A., Belangero, Sintia Iole, and Brietzke, Elisa
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- 2017
- Full Text
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41. Child Maltreatment and Clinical Outcome in Individuals at Ultra-High Risk for Psychosis in the EU-GEI High Risk Study
- Author
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Kraan, Tamar C., Velthorst, Eva, Themmen, Manouk, Valmaggia, Lucia, Kempton, Matthew J., McGuire, Phillip, Van Os, Jim, Rutten, Bart P.F., Smit, Filip, De Haan, Lieuwe, Van Der Gaag, Mark, McGuire, Philip, Valmaggia, Lucia R., Calem, Maria, Tognin, Stefania, Modinos, Gemma, Burger, Nadine, Van Dam, Daniella S., Barrantes-Vidal, Neus, Domínguez-Martínez, Tecelli, Cristóbal-Narváez, Paula, Kwapil, Thomas R., Monsonet-Bardají, Manel, Hinojosa, Lídia, Riecher-Rössler, Anita, Borgwardt, Stefan, Rapp, Charlotte, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Ruhrmann, Stephan, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Naumann, Tanya Louise, Glenthøj, Louise Birkedal, Nordentoft, Merete, De Hert, Marc, Van Winkel, Ruud, Nelson, Barnaby, McGorry, Patrick, EU-GEI High Risk Study, Kraan, Tamar C., Velthorst, Eva, Themmen, Manouk, Valmaggia, Lucia, Kempton, Matthew J., McGuire, Phillip, Van Os, Jim, Rutten, Bart P.F., Smit, Filip, De Haan, Lieuwe, Van Der Gaag, Mark, McGuire, Philip, Valmaggia, Lucia R., Calem, Maria, Tognin, Stefania, Modinos, Gemma, Burger, Nadine, Van Dam, Daniella S., Barrantes-Vidal, Neus, Domínguez-Martínez, Tecelli, Cristóbal-Narváez, Paula, Kwapil, Thomas R., Monsonet-Bardají, Manel, Hinojosa, Lídia, Riecher-Rössler, Anita, Borgwardt, Stefan, Rapp, Charlotte, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Ruhrmann, Stephan, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Naumann, Tanya Louise, Glenthøj, Louise Birkedal, Nordentoft, Merete, De Hert, Marc, Van Winkel, Ruud, Nelson, Barnaby, McGorry, Patrick, and EU-GEI High Risk Study
- Abstract
Background: Child maltreatment has been associated with a wide range of mental disorders in adulthood. Whether child maltreatment is specifically associated with psychosis risk in individuals at ultra-high risk (UHR) for psychosis, or leads to a general vulnerability for overall psychopathology in the UHR stage remains unclear. The present study examines the association between child maltreatment and transition to psychosis and other mental disorders. Methods: The sample consisted of 259 UHR individuals from the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Participants were followed-up for 2 years to assess clinical outcome. Clinical outcome was assessed at 6 months, 12 months, and 24 months after baseline. Child maltreatment before the age of 17 years was assessed at baseline. Results: Our findings show that a history of emotional abuse was associated with an increased risk for transition to psychosis (OR = 3.78, 95% CI = 1.17 to 12.39, P = -027). Apart from psychosis, a history of physical abuse was associated with depressive disorder (OR = 4.92, 95% CI = 2.12 to 11.39, P = .001), post-traumatic stress disorder (OR = 2.06, 95% CI = 1.10 to 3.86, P = .023), panic disorder (OR = 2.00, 95% CI = 1.00 to 3.99, P = .048) and social phobia (OR = 2.47, 95% CI = 1.18 to 5.16, P = .016) at follow-up. Conclusion: Our findings suggest that in the UHR stage child maltreatment is a pluripotent risk factor for developing psychosis, depressive disorder, post-traumatic stress disorder (PTSD), panic disorder, and social phobia in adulthood.
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- 2018
- Full Text
- View/download PDF
42. Clinical utility of ICD‐11 diagnostic guidelines for high‐burden mental disorders: results from mental health settings in 13 countries
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Reed, Geoffrey M., primary, Keeley, Jared W., additional, Rebello, Tahilia J., additional, First, Michael B., additional, Gureje, Oye, additional, Ayuso‐Mateos, José Luis, additional, Kanba, Shigenobu, additional, Khoury, Brigitte, additional, Kogan, Cary S., additional, Krasnov, Valery N., additional, Maj, Mario, additional, de Jesus Mari, Jair, additional, Sharan, Pratap, additional, Stein, Dan J., additional, Zhao, Min, additional, Akiyama, Tsuyoshi, additional, Andrews, Howard F., additional, Asevedo, Elson, additional, Cheour, Majda, additional, Domínguez‐Martínez, Tecelli, additional, El‐Khoury, Joseph, additional, Fiorillo, Andrea, additional, Grenier, Jean, additional, Gupta, Nitin, additional, Kola, Lola, additional, Kulygina, Maya, additional, Leal‐Leturia, Itziar, additional, Luciano, Mario, additional, Lusu, Bulumko, additional, Martínez‐López, J. Nicolás I., additional, Matsumoto, Chihiro, additional, Odunleye, Mayokun, additional, Onofa, Lucky Umukoro, additional, Paterniti, Sabrina, additional, Purnima, Shivani, additional, Robles, Rebeca, additional, Sahu, Manoj K., additional, Sibeko, Goodman, additional, Zhong, Na, additional, Gaebel, Wolfgang, additional, Lovell, Anne M., additional, Maruta, Toshimasa, additional, Pike, Kathleen M., additional, Roberts, Michael C., additional, and Medina‐Mora, María Elena, additional
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- 2018
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43. The ICD-11 developmental field study of reliability of diagnoses of high-burden mental disorders: results among adult patients in mental health settings of 13 countries
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Reed, Geoffrey M., primary, Sharan, Pratap, additional, Rebello, Tahilia J., additional, Keeley, Jared W., additional, Elena Medina-Mora, María, additional, Gureje, Oye, additional, Luis Ayuso-Mateos, José, additional, Kanba, Shigenobu, additional, Khoury, Brigitte, additional, Kogan, Cary S., additional, Krasnov, Valery N., additional, Maj, Mario, additional, de Jesus Mari, Jair, additional, Stein, Dan J., additional, Zhao, Min, additional, Akiyama, Tsuyoshi, additional, Andrews, Howard F., additional, Asevedo, Elson, additional, Cheour, Majda, additional, Domínguez-Martínez, Tecelli, additional, El-Khoury, Joseph, additional, Fiorillo, Andrea, additional, Grenier, Jean, additional, Gupta, Nitin, additional, Kola, Lola, additional, Kulygina, Maya, additional, Leal-Leturia, Itziar, additional, Luciano, Mario, additional, Lusu, Bulumko, additional, Nicolas, J., additional, Martínez-López, I., additional, Matsumoto, Chihiro, additional, Umukoro Onofa, Lucky, additional, Paterniti, Sabrina, additional, Purnima, Shivani, additional, Robles, Rebeca, additional, Sahu, Manoj K., additional, Sibeko, Goodman, additional, Zhong, Na, additional, First, Michael B., additional, Gaebel, Wolfgang, additional, Lovell, Anne M., additional, Maruta, Toshimasa, additional, Roberts, Michael C., additional, and Pike, Kathleen M., additional
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- 2018
- Full Text
- View/download PDF
44. Ten-year evolution of suicide rates and economic indicators in large Brazilian urban centers
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Asevedo, Elson, primary, Ziebold, Carolina, additional, Diniz, Elton, additional, Gadelha, Ary, additional, and Mari, Jair, additional
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- 2018
- Full Text
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45. An immunological age index in bipolar disorder: A confirmatory factor analysis of putative immunosenescence markers and associations with clinical characteristics
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Rizzo, Lucas B., primary, Swardfager, Walter, additional, Maurya, Pawan Kumar, additional, Graiff, Maiara Zeni, additional, Pedrini, Mariana, additional, Asevedo, Elson, additional, Cassinelli, Ana Cláudia, additional, Bauer, Moisés E., additional, Cordeiro, Quirino, additional, Scott, Jan, additional, Brietzke, Elisa, additional, and Cogo‐Moreira, Hugo, additional
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- 2018
- Full Text
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46. Peripheral levels of superoxide dismutase and glutathione peroxidase in youths in ultra-high risk for psychosis: a pilot study
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Zeni-Graiff, Maiara, primary, Rios, Adiel C., additional, Maurya, Pawan K., additional, Rizzo, Lucas B., additional, Sethi, Sumit, additional, Yamagata, Ana S., additional, Mansur, Rodrigo B., additional, Pan, Pedro M., additional, Asevedo, Elson, additional, Cunha, Graccielle R., additional, Zugman, André, additional, Bressan, Rodrigo A., additional, Gadelha, Ary, additional, and Brietzke, Elisa, additional
- Published
- 2017
- Full Text
- View/download PDF
47. Serum copeptin in children exposed to maltreatment
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Coelho, Roberta, Levandowski, Mateus L., Mansur, Rodrigo B., Cunha, Graccielle Rodrigues da [UNIFESP], Asevedo, Elson [UNIFESP], Zugman, Andre [UNIFESP], Salum, Giovanni A., Gadelha, Ary [UNIFESP], Pan, Pedro Mario [UNIFESP], Rizzo, Lucas Bortolotto [UNIFESP], Manfro, Gisele, Mari, Jair de Jesus [UNIFESP], Rohde, Luis A., Miguel, Euripedes C., Bressan, Rodrigo Affonseca [UNIFESP], Brietzke, Elisa [UNIFESP], and Grassi-Oliveira, Rodrigo
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stress ,child psychopathology ,child abuse ,copeptin ,hypothalamic-pituitary-adrenal axis - Abstract
National Institute of Developmental Psychiatry for Children and Adolescents, a science and technology institute Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) AimChildhood maltreatment (CM) has been related to a persistent reprograming of stress-response. Copeptin is a marker of hypothalamic-pituitary-adrenal axis activation however, few studies have examined copeptin levels in children exposed to CM. The aim of this study was to compare serum copeptin levels in children reporting child abuse and/or neglect and children with no history of CM. MethodsThis study included 65 children with a positive history of moderate to severe CM, as reported by themselves and their parent(s) during a clinical interview, and 71 children with no history of CM as a comparison group. CM was considered moderate to severe based on the child-reported frequency of being exposed to events related to sexual abuse, physical abuse, emotional abuse, emotional neglect, and/or physical neglect. Child psychopathology symptoms were assessed using the Child Behavior Checklist (CBCL). We measured serum copeptin concentration using enzyme-linked immunosorbent assay. ResultsChildren exposed to CM exhibited higher levels of serum copeptin compared to children without CM when controlling for sex, age, and psychiatric morbidity. The CBCL total score, including internalizing and externalizing symptoms, was higher in children with CM. We found no correlation between copeptin and CBCL scores for internalizing symptoms and externalizing symptoms. Conclusion CM is associated with copeptin serum levels independently of age, sex, and symptom severity. Copeptin is a promising new biomarker for children with a history of abuse and/or neglect. Pontifical Catholic Univ Rio Grande Sul PUCRS, DCNL, Ave Ipiranga 6681,Predio 11,Sala 928 Partenon, BR-90619900 Porto Alegre, RS, Brazil Univ Fed Rio Grande do Sul, Dept Psychiat, Porto Alegre, RS, Brazil CNPq, Natl Inst Dev Psychiat Children & Adolescents, Sao Paulo, Brazil Fed Univ Sao Paulo UNIFESP, Dept Psychiat, Sao Paulo, Brazil Univ Fed Sao Paulo, Interdisciplinary Lab Clin Neurosci LINC, Sao Paulo, Brazil Univ Sao Paulo, Inst Psychiat IPq, Sao Paulo, Brazil Univ Toronto, Univ Hlth Network, MDPU, Toronto, ON, Canada Department of Psychiatry, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil CNPq: 573974/2008-0 CNPq: 305141/2011-2 CNPq: 476468/ 2012-4 FAPESP: 2008/57896-8 Web of Science
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- 2016
48. Microbiota abnormalities and the therapeutic potential of probiotics in the treatment of mood disorders
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Rios, Adiel C., primary, Maurya, Pawan Kumar, additional, Pedrini, Mariana, additional, Zeni-Graiff, Maiara, additional, Asevedo, Elson, additional, Mansur, Rodrigo B., additional, Wieck, Andrea, additional, Grassi-Oliveira, Rodrigo, additional, McIntyre, Roger S., additional, Hayashi, Mirian A.F., additional, and Brietzke, Elisa, additional
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- 2017
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- View/download PDF
49. NMR Spectroscopy Metabolomics Applied to Crack Cocaine Users and Patients with Schizophrenia: Similar Behavior but Different Molecular Causes
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Tasic, Ljubica, primary, de Moraes Pontes, João Guilherme, additional, de Souza, Rafael Nogueira, additional, Brasil, Antonio Jadson Marreiro, additional, de Faria Cruz, Guilherme Crispim, additional, Asevedo, Elson, additional, Mas, Caroline Dal, additional, Poppi, Ronei Jesus, additional, Brietzke, Elisa, additional, Hayashi, Mirian Akemi Furuie, additional, and Lacerda, Acioly Luiz Tavares, additional
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- 2017
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50. Brain-derived neurotrophic factor, impaired glucose metabolism, and bipolar disorder course
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Mansur, Rodrigo B, Santos, Camila M, Rizzo, Lucas B, Asevedo, Elson, Cunha, Graccielle R, Noto, Mariane N, Pedrini, Mariana, Zeni-Graiff, Maiara, Cordeiro, Quirino, Vinberg, Maj, Kapczinski, Flavio, McIntyre, Roger S, Brietzke, Elisa, Mansur, Rodrigo B, Santos, Camila M, Rizzo, Lucas B, Asevedo, Elson, Cunha, Graccielle R, Noto, Mariane N, Pedrini, Mariana, Zeni-Graiff, Maiara, Cordeiro, Quirino, Vinberg, Maj, Kapczinski, Flavio, McIntyre, Roger S, and Brietzke, Elisa
- Abstract
OBJECTIVES: The neurotrophin brain-derived neurotrophic factor (BDNF) has been proposed as a potential biomarker in bipolar disorder (BD). However, current evidence is limited and results have been highly heterogeneous. This study aimed to assess the moderating effect of impaired glucose metabolism (IGM) on plasma levels of BDNF in individuals with BD, and on the relationship between BDNF and variables of illness course.METHODS: We measured and compared the plasma levels of BDNF in individuals with BD (n=57) and healthy controls (n=26). IGM was operationalized as pre-diabetes or type 2 diabetes mellitus. Information related to current and past psychiatric/medical history, as well as prescription of pharmacological treatments was also captured.RESULTS: Individuals with BD had lower levels of BDNF, relative to healthy controls, after adjustment for age, gender, current medications, smoking, alcohol use, and IGM (P=.046). There was no effect of IGM (P=.860) and no interaction between BD diagnosis and IGM (P=.893). Peripheral BDNF levels were positively correlated with lifetime depressive episodes (P<.001), psychiatric hospitalizations (P=.001) and suicide attempts (P=.021). IGM moderated the association between BDNF and the number of previous mood episodes (P<.001), wherein there was a positive correlation in euglycemic participants and a negative correlation in individuals with IGM.CONCLUSIONS: BD is independently associated with lower levels of BDNF; IGM may modify the relationship between BDNF and BD course, suggesting an interactive effect of BDNF with metabolic status on illness progression.
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- 2016
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