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6. Cognitive impairment after recovery from COVID-19: Frequency, profile, and relationships with clinical and laboratory indices

Author

Onorato, Lorenzo, Giugliano, Gennaro, Livoti, Maria Laura, Caulo, Chiara, Ceres, Rossella, Polverino, Benedetto Maria, Nibbio, Gabriele, Pinton, Irene Calzavara, Sala, Emma, Aguglia, Andrea, Vena, Antonio, Barisione, Emanuela, Bianciardi, Emanuela, Nastro, Federico Fiori, Pelle, Martina, Galderisi, Silvana, Perrottelli, Andrea, Giuliani, Luigi, Pisaturo, Maria Antonietta, Monteleone, Palmiero, Pagliano, Pasquale, Vita, Antonio, Muiesan, Maria Lorenza, Amore, Mario, Bassetti, Matteo, Siracusano, Alberto, Mucci, Armida, Bucci, Paola, Cascino, Giammarco, Barlati, Stefano, Amerio, Andrea, Di Lorenzo, Giorgio, Niolu, Cinzia, Coppola, Nicola, and Maj, Mario

Published
2024
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8. Cannabis use in repeated representative cross-sectional studies on Italian adults after the COVID-19 pandemic

Author

Monti, Filippo, Molinaro, Sabrina, Cerrai, Sonia, Biagioni, Silvia, Voller, Fabio, Andreoni, Elena, Pacifici, Martina, Patussi, Valentino, Cresci, Chiara, Cirone, Donatello, Amerio, Andrea, Stival, Chiara, Bosetti, Cristina, Carreras, Giulia, Fanucchi, Tiziana, Gorini, Giuseppe, Lugo, Alessandra, Pacifici, Roberta, Serafini, Gianluca, Odone, Anna, and Gallus, Silvano

Published
2023
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9. COVID-19 pandemic impact on mental health in a large representative sample of older adults from the Lombardy region, Italy

Author

Bosetti, Cristina, Jarach, Carlotta Micaela, Santucci, Claudia, Amore, Mario, De Sena, Roberto, Ghislandi, Simone, Wang, Yuxi, Bonaccio, Marialaura, Gianfagna, Francesco, Signorelli, Carlo, Mosconi, Giansanto, Vigezzi, Giacomo Pietro, Rognoni, Magda, Paroni, Luca, Ciampichini, Roberta, Amerio, Andrea, Stival, Chiara, Lugo, Alessandra, Fanucchi, Tiziana, d'Oro, Luca Cavalieri, Iacoviello, Licia, Odone, Anna, Stuckler, David, Zucchi, Alberto, Serafini, Gianluca, and Gallus, Silvano

Published
2023
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15. COVID-19 pandemic impact on people with diabetes: results from a large representative sample of Italian older adults

Author

Amerio, A., Amore, M., Bertuccio, P., Bonaccio, M., Bosetti, C., Cavalieri d’Oro, L., Ciampichini, R., De Sena, R., Gallus, S., Gianfagna, F., Ghislandi, S., Ghulam, A., Iacoviello, L., Jarach, CM., Lugo, A., Mosconi, G., Odone, A., Rognoni, M., Serafini, G., Scala, M., Signorelli, C., Stival, C., Stuckler, D., Vigezzi, GP., Wang, Y., Zucchi, A., Vigezzi, Giacomo Pietro, Bertuccio, Paola, Bossi, Camilla Bonfadini, Amerio, Andrea, d’Oro, Luca Cavalieri, Derosa, Giuseppe, Iacoviello, Licia, Stuckler, David, Zucchi, Alberto, Lugo, Alessandra, Gallus, Silvano, and Odone, Anna

Published
2022
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17. Demoralization in suicide: A systematic review

Author

Costanza, Alessandra, Vasileios, Chytas, Ambrosetti, Julia, Shah, Sanam, Amerio, Andrea, Aguglia, Andrea, Serafini, Gianluca, Piguet, Valérie, Luthy, Christophe, Cedraschi, Christine, Bondolfi, Guido, and Berardelli, Isabella

Published
2022
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21. Reactive Astrocytosis—A Potential Contributor to Increased Suicide in Long COVID-19 Patients?

Author

Costanza, Alessandra, Amerio, Andrea, Aguglia, Andrea, Rossi, Martina, Parise, Alberto, Magnani, Luca, Serafini, Gianluca, Amore, Mario, Martins, Daniel, and Nguyen, Khoa D.

Subjects
*POST-acute COVID-19 syndrome, *SUICIDE risk factors, *COVID-19, *SUICIDAL behavior, *SUICIDAL ideation
Abstract

Background: Long COVID-19 is an emerging chronic illness of significant public health concern due to a myriad of neuropsychiatric sequelae, including increased suicidal ideation (SI) and behavior (SB). Methods: This review provides a concise synthesis of clinical evidence that points toward the dysfunction of astrocytes, the most abundant glial cell type in the central nervous system, as a potential shared pathology between SI/SB and COVID-19. Results: Depression, a suicide risk factor, and SI/SB were both associated with reduced frequencies of various astrocyte subsets and complex proteomic/transcriptional changes of astrocyte-related markers in a brain-region-specific manner. Astrocyte-related circulating markers were increased in depressed subjects and, to a less consistent extent, in COVID-19 patients. Furthermore, reactive astrocytosis was observed in subjects with SI/SB and those with COVID-19. Conclusions: Astrocyte dysfunctions occurred in depression, SI/SB, and COVID-19. Reactive-astrocyte-mediated loss of the blood–brain barrier (BBB) integrity and subsequent neuroinflammation—a factor previously linked to SI/SB development—might contribute to increased suicide in individuals with long COVID-19. As such, the formulation of new therapeutic strategies to restore astrocyte homeostasis, enhance BBB integrity, and mitigate neuroinflammation may reduce SI/SB-associated neuropsychiatric manifestations among long COVID-19 patients. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Advances in the management of bipolar disorder in children and adolescents: an update on the literature.

Author

Amerio, Andrea, Arduino, Gabriele, Fesce, Fabio, Costanza, Alessandra, Aguglia, Andrea, Amore, Mario, and Serafini, Gianluca

Abstract

Introduction: Early diagnosis and treatment concerning bipolar disorder (BD) are related to a better functioning over the long-term period. Although pharmacotherapy is indicated for approximately all youths with BD, nearly one-third of patients do not receive adequate medications for their condition. Areas covered: The authors discuss the available scientific evidence from the current literature about the management of BD in both children and adolescents, giving particular focus to the efficacy and tolerability of the available pharmacological agents. Studies were identified searching MEDLINE and retrieved from reference listings of relevant articles and through consultation with experts in the field. Expert opinion: Many D2-blockers, approved by the Food and Drug Administration (FDA) based on their antimanic properties in youths, are related to both short- and long-term side effects. Lurasidone was found to be effective for the treatment of acute juvenile bipolar depression, while lithium for the treatment and recurrence prevention of manic/mixed episodes. The most common anticonvulsants were found to be most useful as adjunctive antimanic agents in non-responders to first-line monotherapies. No data was found to support the use of antidepressants in juvenile BD. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Characterization of Bipolar Disorder I and II: Clinical Features, Comorbidities, and Pharmacological Pattern.

Author

Aguglia, Andrea, Giacomini, Gabriele, De Michiel, Clio F., Garbarino, Nicolò, Lechiara, Alessio, Magni, Caterina, Meinero, Matteo, Verrina, Edoardo, Costanza, Alessandra, Amerio, Andrea, Amore, Mario, and Serafini, Gianluca

Subjects
AFFECTIVE disorders, ATTEMPTED suicide, SUICIDAL behavior, BIPOLAR disorder, MOOD stabilizers
Abstract

Objective: Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition provides precise diagnostic criteria to differentiate between bipolar disorder (BD) type I and II; nevertheless, it can be challenging to come up with the right diagnosis. The aim of this study is to evaluate the sociodemographic differences, clinical features, comorbidities, and pharmacological pattern between patients with BD type I and II. Methods: A total of 680 patients with BD type I and II were consecutively recruited to our psychiatry department. A semi-structured interview was used to collect several information. Results: Patients with BD type I were mostly males, single, with a lower current age, and unemployed compared to patients with BD type II. Furthermore, patients with BD type I showed an earlier age at onset and a significant higher prevalence of psychotic and residual symptoms, a higher number of hospitalizations, and involuntary admissions. On the other hand, patients with BD type II were associated with a significant higher prevalence of lifetime suicide attempts, psychiatric comorbidities, and use of alcohol. Finally, antidepressant drugs were prescribed more often to patients with BD type II, while antipsychotics and mood stabilizers were mostly prescribed in patients with BD type I. Conclusion: the differentiation of the 2 nosologic bipolar diagnosis is in line with the current scientific interest, confirming the existence of a markedly different profile between BD type I and II. This differentiation could reduce the heterogeneity of bipolar presentation in research, optimize clinical assessment, and increase the interest in developing more precise and individualized therapeutic strategies, also implementing psychosocial therapies. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Rethinking the role of trazodone in the different depressive dimensions.

Author

Berardelli, Isabella, Amerio, Andrea, Bartoli, Francesco, Cuomo, Alessandro, Deste, Giacomo, Orsolini, Laura, Sampogna, Gaia, and Pompili, Maurizio

Abstract

The efficacy of trazodone for several psychopathologic dimensions of depression has been shown in the literature. Trazodone has been widely used in some clinical contexts (e.g. for insomnia and depression in the elderly). However, the role of trazodone in several aspects of depression is not well known. Eight experts from academic and medical centers across Italy met to identify the difficulties and barriers faced in daily clinical practice in the assessment and management of major depressive disorder and how the use of trazodone could address some unmet needs. The objective of the expert meetings and the present document was to increase knowledge of particular areas of treatment with trazodone. Evidence of the role of trazodone in patients affected by major depressive disorder with anxiety symptoms, insomnia, agitation, cognitive deficits, alcohol use disorders, physical comorbidities, and suicide risk has been identified, showing the effectiveness of trazodone in different presentations of major depressive disorder. The main characteristics of patients with depression for whom trazodone seems to be most effective have been identified, providing clinicians with information on possible uses of this drug in such population of patients. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Obsessive–Compulsive Disorder as an Epiphenomenon of Comorbid Bipolar Disorder? An Updated Systematic Review

Author

de Filippis, Renato, primary, Aguglia, Andrea, additional, Costanza, Alessandra, additional, Benatti, Beatrice, additional, Placenti, Valeria, additional, Vai, Eleonora, additional, Bruno, Edoardo, additional, De Berardis, Domenico, additional, Dell’Osso, Bernardo, additional, Albert, Umberto, additional, De Fazio, Pasquale, additional, Amore, Mario, additional, Serafini, Gianluca, additional, Ghaemi, Nassir S., additional, and Amerio, Andrea, additional

Published
2024
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37. Cognitive impairment after recovery from COVID-19: Frequency, profile, and relationships with clinical and laboratory indices

Author

Galderisi, Silvana, primary, Perrottelli, Andrea, additional, Giuliani, Luigi, additional, Pisaturo, Maria Antonietta, additional, Monteleone, Palmiero, additional, Pagliano, Pasquale, additional, Vita, Antonio, additional, Muiesan, Maria Lorenza, additional, Amore, Mario, additional, Bassetti, Matteo, additional, Siracusano, Alberto, additional, Mucci, Armida, additional, Bucci, Paola, additional, Cascino, Giammarco, additional, Barlati, Stefano, additional, Amerio, Andrea, additional, Di Lorenzo, Giorgio, additional, Niolu, Cinzia, additional, Coppola, Nicola, additional, and Maj, Mario, additional

Published
2024
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38. A Prospective Multicenter Longitudinal Analysis of Suicidal Ideation among Long-COVID-19 Patients

Author

Costanza, Alessandra, primary, Amerio, Andrea, additional, Aguglia, Andrea, additional, Magnani, Luca, additional, Alexander, Jacques, additional, Maiorano, Alessandra, additional, Richard-Lepouriel, Hélène, additional, Portacolone, Elena, additional, Berardelli, Isabella, additional, Pompili, Maurizio, additional, Serafini, Gianluca, additional, Amore, Mario, additional, and Nguyen, Khoa D., additional

Published
2024
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39. Characterization of Psychiatric Inpatients: The Role of Gender Differences in Clinical and Pharmacological Patterns

Author

Berardelli, Isabella, primary, Aguglia, Andrea, additional, Amerio, Andrea, additional, Sarubbi, Salvatore, additional, Rogante, Elena, additional, Trocchia, Maria A., additional, Zelletta, Davide, additional, Longhini, Ludovica, additional, Erbuto, Denise, additional, Pastorino, Fabrizio, additional, Lamis, Dorian A., additional, Innamorati, Marco, additional, Serafini, Gianluca, additional, and Pompili, Maurizio, additional

Published
2024
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40. Evening Chronotype and Suicide: Exploring Neuroinflammation and Psychopathological Dimensions as Possible Bridging Factors—A Narrative Review

Author

Magnani, Luca, primary, Aguglia, Andrea, additional, Alexander, Jacques, additional, Maiorano, Alessandra, additional, Richard-Lepouriel, Hélène, additional, Iancau, Sidonia Paula, additional, Amerio, Andrea, additional, Parise, Alberto, additional, Serafini, Gianluca, additional, Amore, Mario, additional, Nguyen, Khoa D., additional, and Costanza, Alessandra, additional

Published
2023
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44. Health and social home services among community-dwelling older people during COVID-19: Results from the cross-sectional LOST in Lombardia project.

Author

Bertuccio, Paola, Vigezzi, Giacomo Pietro, Amerio, Andrea, Cavalieri D'oro, Luca, Iacoviello, Licia, Stuckler, David, Signorelli, Carlo, Zucchi, Alberto, Gallus, Silvano, and Odone, Anna

Subjects
COMMUNITY health services, CROSS-sectional method, INDEPENDENT living, MENTAL health, RESEARCH funding, SOCIAL services, LOGISTIC regression analysis, MULTIVARIATE analysis, DESCRIPTIVE statistics, SOCIAL case work, CHRONIC diseases, ODDS ratio, CAREGIVERS, SOCIODEMOGRAPHIC factors, CONFIDENCE intervals, COMMUNITY services, COVID-19 pandemic
Abstract

Background: Few studies have focused on changes in health and social services access due to the COVID-19 pandemic. We aimed to describe changes in the use of selected health and social home services due to the pandemic and to investigate potential associated factors, including socio-demographic characteristics, number of chronic diseases and mental health indicators, among older Italian individuals. Methods: We analysed data from the LOST in Lombardia cross-sectional study conducted in November 2020 on a large representative sample of 4400 individuals aged ⩾65 years. To identify potential factors associated with the increased use of three selected health and social home services, we estimated odds ratios (OR) and confidence intervals (CI) using multivariable logistic regression models. Results: Compared to the year before, 5.0% of older adults increased help from domestic workers (vs. 6.9% reducing) during the pandemic, 4.4% increased help from non-familiar caregivers (vs. 1.3% decreasing) and 4.7% increased medical home visits (vs. 1.0% decreasing). An increase in the use of these services was more frequent among participants with co-morbidities (p for trend <0.001), especially with diabetes (for caregivers: OR=12.2, 95% CI 6.0–24.8), and worse mental health (for caregivers and for those with a GAD-2 score ⩾3 vs. <3: OR=10.6, 95% CI 5.8–19.4). Conversely, people living in more crowded households less frequently increased health and social services use during the pandemic. Conclusions: Our results should inform targeted interventions for the identified vulnerable groups to close the gap in health and social inequities. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Mechanical Restraint in Inpatient Psychiatric Unit: Prevalence and Associated Clinical Variables

Author

Aguglia, Andrea, primary, Corsini, Giovanni Pietro, additional, Berardelli, Isabella, additional, Berti, Andrea, additional, Conio, Benedetta, additional, Garbarino, Nicolò, additional, Gnecco, Giovanni Battista, additional, Magni, Caterina, additional, Venturini, Enrico, additional, Costanza, Alessandra, additional, Amerio, Andrea, additional, Amore, Mario, additional, and Serafini, Gianluca, additional

Published
2023
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46. Virtual reality as a novel therapeutic approach to Hikikomori.

Author

Aguglia, Andrea, Masini, Filippo, Franziska De Michiel, Clio, Amerio, Andrea, Orsolini, Laura, Volpe, Umberto, and Serafini, Gianluca

Subjects
FAMILY psychotherapy, DIGITAL health, VIRTUAL reality, PATIENT-centered care, INTERPERSONAL relations, SOCIAL isolation
Abstract

The article focuses on the potential use of Virtual Reality (VR) as a therapeutic tool for treating Hikikomori, a severe form of social withdrawal, by providing an immersive environment to engage individuals in social interactions and support their recovery.

Published
2024
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47. Clozapine in a Young Female with Drug-Resistant Schizophrenia: A Case Report of Development of Serositis

Author

Aguglia, Andrea, Parisi, Valentina Maria, Arduino, Gabriele, Amerio, Andrea, Costanza, Alessandra, Serafini, Gianluca, and Amore, Mario

Subjects
Pharmacology, side effects, Treatment-Resistant Schizophrenia (TRS), clozapine, General Neuroscience, Schizophrenia, case report, serositis
Abstract

Background: Clozapine may be considered the first-line option for treatment-resistant schizophrenia (TRS), a condition that occurs in more than 30% of patients with schizophrenia. Despite its efficacy for treating TRS, clozapine use is limited by the occurrence of several adverse effects in more than 70% of cases. Clozapine does not typically affect lung function, although a few cases have been reported in the literature. Case Presentation: To gain a better understanding of this rare event, here we report the case study of a young female with TRS, who was treated with clozapine and developed medium and bilateral pleural effusion relief with contiguous atelectasis and polyserositis. Two weeks after stopping clozapine, the follow-up chest scan showed complete remission of the pulmonary condition. We postulate that clozapine might have caused, in this case, a specific immunoinflammatory response leading to serosal complications. Conclusion: Although the underlying mechanisms of this adverse effect are not completely understood, early manifestations, such as benign eosinophilia, fever, and flu-like symptoms need to be considered a potential warning to facilitate an early diagnosis and carefully manage pulmonary complications related to clozapine treatment.

Published
2023
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49. The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study

Author

Antonio Vita, Stefano Barlati, Giacomo Deste, Paola Rocca, Alessandro Rossi, Alessandro Bertolino, Eugenio Aguglia, Mario Amore, Antonello Bellomo, Massimo Biondi, Bernardo Carpiniello, Enrico Collantoni, Alessandro Cuomo, Enrico D’Ambrosio, Liliana dell’ Osso, Massimo di Giannantonio, Giulia Maria Giordano, Carlo Marchesi, Palmiero Monteleone, Cristiana Montemagni, Lucio Oldani, Maurizio Pompili, Rita Roncone, Rodolfo Rossi, Alberto Siracusano, Patrizia Zeppegno, Gabriele Nibbio, Silvana Galderisi, Mario Maj, and Italian Network for Research on Psychoses Ceraso Anna University of Brescia Galluzzo Alessandro University of Brescia Lisoni Jacopo University of Brescia Di Palo Piergiuseppe University of Bari Papalino Marco University of Bari Romano Raffaella University of Bari Pinna Federica University of Cagliari Lai Alice University of Cagliari di Santa Sofia Silvia Lostia University of Cagliari Bucci Paola University of Campania “L. Vanvitelli,” Naples Piegari Giuseppe University of Campania “L. Vanvitelli,” Naples Brando Francesco University of Campania “L. Vanvitelli,” Naples Giuliani Luigi University of Campania “L. Vanvitelli,” Naples Signorelli Maria Salvina University of Catania Fusar Poli Laura University of Catania Martinotti Giovanni University of Chieti Pettorruso Mauro University of Chieti Montemitro Chiara University of Chieti Altamura Mario University of Foggia Malerba Stefania University of Foggia Padalino Flavia University of Foggia Amerio Andrea University of Genoa Calcagno Pietro University of Genoa Zampogna Domenico University of Genoa Giusti Laura University of L’Aquila Salza Anna University of L’Aquila Mammarella Silvia University of L’Aquila Pacitti Francesca University of L’Aquila Socci Valentina University of L’Aquila Talevi Dalila University of L’Aquila Gramaglia Carla University of Eastern Piedmont, Novara Feggi Alessandro University of Eastern Piedmont, Novara Jona Amalia University of Eastern Piedmont, Novara Favaro Angela University of Padua Tenconi Elena University of Padua Meneguzzo Paolo University of Padua Ossola Paolo University of Parma Tonna Matteo University of Parma Gerra Maria Lidia University of Parma Carmassi Claudia University of Pisa Gesi Camilla University of Pisa Carpita Barbara University of Pisa Corrivetti Giulio Department of Mental Health, Salerno Cascino Giammarco Department of Mental Health, Salerno del Buono Gianfranco Department of Mental Health, Salerno Di Fabio Fabio Sapienza University of Rome Buzzanca Antonio Sapienza University of Rome Girardi Nicoletta Sapienza University of Rome Brugnoli Roberto Sapienza University of Rome Comparelli Anna Sapienza University of Rome Corigliano Valentina Sapienza University of Rome Fagiolini Andrea University of Siena Bolognesi Simone University of Siena Goracci Arianna University of Siena Di Lorenzo Giorgio Tor Vergata University of Rome Niolu Cinzia Tor Vergata University of Rome Ribolsi Michele Tor Vergata University of Rome Brasso Claudio University of Turin Riccardi Cecilia University of Turin Del Favero Elisa University of Turin

Subjects
autism spectrum disorders, cognition, psychosocial functioning, schizophrenia, social cognition, Psychiatry, RC435-571
Abstract

Abstract Background Autism spectrum disorders (ASDs) and schizophrenia spectrum disorders (SSDs), although conceptualized as separate entities, may share some clinical and neurobiological features. ASD symptoms may have a relevant role in determining a more severe clinical presentation of schizophrenic disorder but their relationships with cognitive aspects and functional outcomes of the disease remain to be addressed in large samples of individuals. Aims To investigate the clinical, cognitive, and functional correlates of ASD symptoms in a large sample of people diagnosed with schizophrenia. Methods The severity of ASD symptoms was measured with the PANSS Autism Severity Scale (PAUSS) in 921 individuals recruited for the Italian Network for Research on Psychoses multicenter study. Based on the PAUSS scores, three groups of subjects were compared on a wide array of cognitive and functional measures. Results Subjects with more severe ASD symptoms showed a poorer performance in the processing speed (p = 0.010), attention (p = 0.011), verbal memory (p = 0.035), and social cognition (p = 0.001) domains, and an overall lower global cognitive composite score (p = 0.010). Subjects with more severe ASD symptoms also showed poorer functional capacity (p = 0.004), real-world interpersonal relationships (p

Published
2020
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