277 results on '"Alemany, Silvia"'
Search Results
2. Machine learning-based health environmental-clinical risk scores in European children
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Guimbaud, Jean-Baptiste, Siskos, Alexandros P., Sakhi, Amrit Kaur, Heude, Barbara, Sabidó, Eduard, Borràs, Eva, Keun, Hector, Wright, John, Julvez, Jordi, Urquiza, Jose, Gützkow, Kristine Bjerve, Chatzi, Leda, Casas, Maribel, Bustamante, Mariona, Nieuwenhuijsen, Mark, Vrijheid, Martine, López-Vicente, Mónica, de Castro Pascual, Montserrat, Stratakis, Nikos, Robinson, Oliver, Grazuleviciene, Regina, Slama, Remy, Alemany, Silvia, Basagaña, Xavier, Plantevit, Marc, Cazabet, Rémy, and Maitre, Léa
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- 2024
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3. Transcriptomic risk scores for attention deficit/hyperactivity disorder
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Cabana-Domínguez, Judit, Llonga, Natalia, Arribas, Lorena, Alemany, Silvia, Vilar-Ribó, Laura, Demontis, Ditte, Fadeuilhe, Christian, Corrales, Montse, Richarte, Vanesa, Børglum, Anders D., Ramos-Quiroga, Josep Antoni, Soler Artigas, María, and Ribasés, Marta
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- 2023
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4. Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms
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Jami, Eshim S, Hammerschlag, Anke R, Ip, Hill F, Allegrini, Andrea G, Benyamin, Beben, Border, Richard, Diemer, Elizabeth W, Jiang, Chang, Karhunen, Ville, Lu, Yi, Lu, Qing, Mallard, Travis T, Mishra, Pashupati P, Nolte, Ilja M, Palviainen, Teemu, Peterson, Roseann E, Sallis, Hannah M, Shabalin, Andrey A, Tate, Ashley E, Thiering, Elisabeth, Vilor-Tejedor, Natàlia, Wang, Carol, Zhou, Ang, Adkins, Daniel E, Alemany, Silvia, Ask, Helga, Chen, Qi, Corley, Robin P, Ehli, Erik A, Evans, Luke M, Havdahl, Alexandra, Hagenbeek, Fiona A, Hakulinen, Christian, Henders, Anjali K, Hottenga, Jouke Jan, Korhonen, Tellervo, Mamun, Abdullah, Marrington, Shelby, Neumann, Alexander, Rimfeld, Kaili, Rivadeneira, Fernando, Silberg, Judy L, van Beijsterveldt, Catharina E, Vuoksimaa, Eero, Whipp, Alyce M, Tong, Xiaoran, Andreassen, Ole A, Boomsma, Dorret I, Brown, Sandra A, Burt, S Alexandra, Copeland, William, Dick, Danielle M, Harden, K Paige, Harris, Kathleen Mullan, Hartman, Catharina A, Heinrich, Joachim, Hewitt, John K, Hopfer, Christian, Hypponen, Elina, Jarvelin, Marjo-Riitta, Kaprio, Jaakko, Keltikangas-Järvinen, Liisa, Klump, Kelly L, Krauter, Kenneth, Kuja-Halkola, Ralf, Larsson, Henrik, Lehtimäki, Terho, Lichtenstein, Paul, Lundström, Sebastian, Maes, Hermine H, Magnus, Per, Munafò, Marcus R, Najman, Jake M, Njølstad, Pål R, Oldehinkel, Albertine J, Pennell, Craig E, Plomin, Robert, Reichborn-Kjennerud, Ted, Reynolds, Chandra, Rose, Richard J, Smolen, Andrew, Snieder, Harold, Stallings, Michael, Standl, Marie, Sunyer, Jordi, Tiemeier, Henning, Wadsworth, Sally J, Wall, Tamara L, Whitehouse, Andrew JO, Williams, Gail M, Ystrøm, Eivind, Nivard, Michel G, Bartels, Meike, and Middeldorp, Christel M
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Biological Psychology ,Psychology ,Serious Mental Illness ,Brain Disorders ,Pediatric ,Human Genome ,Genetics ,Behavioral and Social Science ,Depression ,Mental Health ,Mental Illness ,2.1 Biological and endogenous factors ,2.3 Psychological ,social and economic factors ,Mental health ,Adolescent ,Adult ,Aggression ,Anxiety ,Attention Deficit Disorder with Hyperactivity ,Autistic Disorder ,Bipolar Disorder ,Child ,Child ,Preschool ,Genome-Wide Association Study ,Humans ,Loneliness ,Polymorphism ,Single Nucleotide ,Schizophrenia ,Sleep Initiation and Maintenance Disorders ,depression ,anxiety ,repeated measures ,genetic epidemiology ,molecular genetics ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Developmental & Child Psychology ,Clinical sciences ,Paediatrics ,Applied and developmental psychology - Abstract
ObjectiveTo investigate the genetic architecture of internalizing symptoms in childhood and adolescence.MethodIn 22 cohorts, multiple univariate genome-wide association studies (GWASs) were performed using repeated assessments of internalizing symptoms, in a total of 64,561 children and adolescents between 3 and 18 years of age. Results were aggregated in meta-analyses that accounted for sample overlap, first using all available data, and then using subsets of measurements grouped by rater, age, and instrument.ResultsThe meta-analysis of overall internalizing symptoms (INToverall) detected no genome-wide significant hits and showed low single nucleotide polymorphism (SNP) heritability (1.66%, 95% CI = 0.84-2.48%, neffective = 132,260). Stratified analyses indicated rater-based heterogeneity in genetic effects, with self-reported internalizing symptoms showing the highest heritability (5.63%, 95% CI = 3.08%-8.18%). The contribution of additive genetic effects on internalizing symptoms appeared to be stable over age, with overlapping estimates of SNP heritability from early childhood to adolescence. Genetic correlations were observed with adult anxiety, depression, and the well-being spectrum (|rg| > 0.70), as well as with insomnia, loneliness, attention-deficit/hyperactivity disorder, autism, and childhood aggression (range |rg| = 0.42-0.60), whereas there were no robust associations with schizophrenia, bipolar disorder, obsessive-compulsive disorder, or anorexia nervosa.ConclusionGenetic correlations indicate that childhood and adolescent internalizing symptoms share substantial genetic vulnerabilities with adult internalizing disorders and other childhood psychiatric traits, which could partially explain both the persistence of internalizing symptoms over time and the high comorbidity among childhood psychiatric traits. Reducing phenotypic heterogeneity in childhood samples will be key in paving the way to future GWAS success.
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- 2022
5. Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants
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Alemany, Silvia, Soler-Artigas, María, Cabana-Domínguez, Judit, Fakhreddine, Dana, Llonga, Natalia, Vilar-Ribó, Laura, Rodríguez-Urrutia, Amanda, Palacio, Judit, González-Castro, Ana María, Lobo, Beatriz, Alonso-Cotoner, Carmen, Simrén, Magnus, Santos, Javier, Ramos-Quiroga, Josep Antoni, and Ribasés, Marta
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- 2023
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6. Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills
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Caramaschi, Doretta, Neumann, Alexander, Cardenas, Andres, Tindula, Gwen, Alemany, Silvia, Zillich, Lea, Pesce, Giancarlo, Lahti, Jari MT, Havdahl, Alexandra, Mulder, Rosa, Felix, Janine F, Tiemeier, Henning, Sirignano, Lea, Frank, Josef, Witt, Stephanie H, Rietschel, Marcella, Deuschle, Michael, Huen, Karen, Eskenazi, Brenda, Send, Tabea Sarah, Ferrer, Muriel, Gilles, Maria, de Agostini, Maria, Baïz, Nour, Rifas-Shiman, Sheryl L, Kvist, Tuomas, Czamara, Darina, Tuominen, Samuli T, Relton, Caroline L, Rai, Dheeraj, London, Stephanie J, Räikkönen, Katri, Holland, Nina, Annesi-Maesano, Isabella, Streit, Fabian, Hivert, Marie-France, Oken, Emily, Sunyer, Jordi, Cecil, Charlotte AM, and Sharp, Gemma
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Biological Psychology ,Reproductive Medicine ,Biomedical and Clinical Sciences ,Psychology ,Clinical Research ,Pediatric ,Human Genome ,Behavioral and Social Science ,Pediatric Research Initiative ,Mental Health ,Genetics ,Aetiology ,2.1 Biological and endogenous factors ,2.2 Factors relating to the physical environment ,Child ,Cognition ,CpG Islands ,DNA Methylation ,Epigenesis ,Genetic ,Epigenome ,Female ,Genome-Wide Association Study ,Humans ,Infant ,Newborn ,Pregnancy ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Clinical sciences ,Biological psychology ,Clinical and health psychology - Abstract
Cognitive skills are a strong predictor of a wide range of later life outcomes. Genetic and epigenetic associations across the genome explain some of the variation in general cognitive abilities in the general population and it is plausible that epigenetic associations might arise from prenatal environmental exposures and/or genetic variation early in life. We investigated the association between cord blood DNA methylation at birth and cognitive skills assessed in children from eight pregnancy cohorts within the Pregnancy And Childhood Epigenetics (PACE) Consortium across overall (total N = 2196), verbal (total N = 2206) and non-verbal cognitive scores (total N = 3300). The associations at single CpG sites were weak for all of the cognitive domains investigated. One region near DUSP22 on chromosome 6 was associated with non-verbal cognition in a model adjusted for maternal IQ. We conclude that there is little evidence to support the idea that variation in cord blood DNA methylation at single CpG sites is associated with cognitive skills and further studies are needed to confirm the association at DUSP22.
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- 2022
7. DNA methylation and general psychopathology in childhood: an epigenome-wide meta-analysis from the PACE consortium
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Rijlaarsdam, Jolien, Cosin-Tomas, Marta, Schellhas, Laura, Abrishamcar, Sarina, Malmberg, Anni, Neumann, Alexander, Felix, Janine F., Sunyer, Jordi, Gutzkow, Kristine B., Grazuleviciene, Regina, Wright, John, Kampouri, Mariza, Zar, Heather J., Stein, Dan J., Heinonen, Kati, Räikkönen, Katri, Lahti, Jari, Hüls, Anke, Caramaschi, Doretta, Alemany, Silvia, and Cecil, Charlotte A. M.
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- 2023
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8. Genetic association study of childhood aggression across raters, instruments, and age.
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Ip, Hill, van der Laan, Camiel, Krapohl, Eva, Brikell, Isabell, Sánchez-Mora, Cristina, Nolte, Ilja, St Pourcain, Beate, Bolhuis, Koen, Palviainen, Teemu, Zafarmand, Hadi, Colodro-Conde, Lucía, Gordon, Scott, Zayats, Tetyana, Aliev, Fazil, Jiang, Chang, Wang, Carol, Saunders, Gretchen, Karhunen, Ville, Hammerschlag, Anke, Adkins, Daniel, Border, Richard, Peterson, Roseann, Prinz, Joseph, Thiering, Elisabeth, Seppälä, Ilkka, Vilor-Tejedor, Natàlia, Ahluwalia, Tarunveer, Day, Felix, Hottenga, Jouke-Jan, Allegrini, Andrea, Rimfeld, Kaili, Chen, Qi, Lu, Yi, Martin, Joanna, Soler Artigas, María, Rovira, Paula, Bosch, Rosa, Español, Gemma, Ramos Quiroga, Josep, Neumann, Alexander, Ensink, Judith, Grasby, Katrina, Morosoli, José, Tong, Xiaoran, Marrington, Shelby, Middeldorp, Christel, Scott, James, Vinkhuyzen, Anna, Shabalin, Andrey, Corley, Robin, Evans, Luke, Sugden, Karen, Alemany, Silvia, Sass, Lærke, Vinding, Rebecca, Ruth, Kate, Tyrrell, Jess, Davies, Gareth, Ehli, Erik, Hagenbeek, Fiona, De Zeeuw, Eveline, Van Beijsterveldt, Toos, Larsson, Henrik, Snieder, Harold, Verhulst, Frank, Amin, Najaf, Whipp, Alyce, Korhonen, Tellervo, Vuoksimaa, Eero, Rose, Richard, Uitterlinden, André, Heath, Andrew, Madden, Pamela, Haavik, Jan, Harris, Jennifer, Helgeland, Øyvind, Johansson, Stefan, Knudsen, Gun, Njolstad, Pal, Lu, Qing, Rodriguez, Alina, Henders, Anjali, Mamun, Abdullah, Najman, Jackob, Brown, Sandy, Hopfer, Christian, Krauter, Kenneth, Reynolds, Chandra, Smolen, Andrew, Stallings, Michael, Wadsworth, Sally, Wall, Tamara, Silberg, Judy, Miller, Allison, Keltikangas-Järvinen, Liisa, Hakulinen, Christian, Pulkki-Råback, Laura, Havdahl, Alexandra, Magnus, Per, and Raitakari, Olli
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Adolescent ,Aggression ,Child ,Child ,Preschool ,Female ,Genetic Association Studies ,Genome-Wide Association Study ,Humans ,Infant ,Mental Disorders ,Retrospective Studies - Abstract
Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors were included. We analyzed phenotype assessments for a total of 328 935 observations from 87 485 children aged between 1.5 and 18 years, while accounting for sample overlap. We also meta-analyzed within subsets of the data, i.e., within rater, instrument and age. SNP-heritability for the overall meta-analysis (AGGoverall) was 3.31% (SE = 0.0038). We found no genome-wide significant SNPs for AGGoverall. The gene-based analysis returned three significant genes: ST3GAL3 (P = 1.6E-06), PCDH7 (P = 2.0E-06), and IPO13 (P = 2.5E-06). All three genes have previously been associated with educational traits. Polygenic scores based on our GWAMA significantly predicted aggression in a holdout sample of children (variance explained = 0.44%) and in retrospectively assessed childhood aggression (variance explained = 0.20%). Genetic correlations (rg) among rater-specific assessment of AGG ranged from rg = 0.46 between self- and teacher-assessment to rg = 0.81 between mother- and teacher-assessment. We obtained moderate-to-strong rgs with selected phenotypes from multiple domains, but hardly with any of the classical biomarkers thought to be associated with AGG. Significant genetic correlations were observed with most psychiatric and psychological traits (range [Formula: see text]: 0.19-1.00), except for obsessive-compulsive disorder. Aggression had a negative genetic correlation (rg = ~-0.5) with cognitive traits and age at first birth. Aggression was strongly genetically correlated with smoking phenotypes (range [Formula: see text]: 0.46-0.60). The genetic correlations between aggression and psychiatric disorders were weaker for teacher-reported AGG than for mother- and self-reported AGG. The current GWAMA of childhood aggression provides a powerful tool to interrogate the rater-specific genetic etiology of AGG.
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- 2021
9. Dissecting the polygenic contribution of attention-deficit/hyperactivity disorder and autism spectrum disorder on school performance by their relationship with educational attainment
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Cabana-Domínguez, Judit, primary, Bosch, Rosa, additional, Soler Artigas, María, additional, Alemany, Silvia, additional, Llonga, Natalia, additional, Vilar-Ribó, Laura, additional, Carabí-Gassol, Pau, additional, Arribas, Lorena, additional, Macias-Chimborazo, Valeria, additional, Español-Martín, Gemma, additional, del Castillo, Clara, additional, Martínez, Laura, additional, Pagerols, Mireia, additional, Pagespetit, Èlia, additional, Prat, Raquel, additional, Puigbó, Julia, additional, Ramos-Quiroga, Josep Antoni, additional, Casas, Miquel, additional, and Ribasés, Marta, additional
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- 2024
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10. Neurogenetics of Dynamic Connectivity Patterns Associated With Obsessive-Compulsive Symptoms in Healthy Children
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Suñol, Maria, Alemany, Silvia, Bustamante, Mariona, Diez, Ibai, Contreras-Rodríguez, Oren, Laudo, Berta, Macià, Dídac, Martínez-Vilavella, Gerard, Martínez-Zalacaín, Ignacio, Menchón, José Manuel, Pujol, Jesús, Sunyer, Jordi, Sepulcre, Jorge, and Soriano-Mas, Carles
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- 2022
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11. Comprehensive analysis of omics data identifies relevant gene networks for Attention-Deficit/Hyperactivity Disorder (ADHD)
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Cabana-Domínguez, Judit, Soler Artigas, María, Arribas, Lorena, Alemany, Silvia, Vilar-Ribó, Laura, Llonga, Natalia, Fadeuilhe, Christian, Corrales, Montse, Richarte, Vanesa, Ramos-Quiroga, Josep Antoni, and Ribasés, Marta
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- 2022
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12. Epigenetic timing effects on child developmental outcomes: A longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium
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Neumann, Alexander, primary, Sammallahti, Sara, additional, Cosin-Tomas, Marta, additional, Reese, Sarah E, additional, Suderman, Matthew, additional, Alemany, Silvia, additional, Almqvist, Catarina, additional, Andrusaityte, Sandra, additional, Arshad, Syed H, additional, Bakermans-Kranenburg, Marian J, additional, Beilin, Lawrence, additional, Breton, Carrie, additional, Bustamante, Mariona, additional, Czamara, Darina, additional, Dabelea, Dana, additional, Eng, Celeste, additional, Eskenazi, Brenda, additional, Fuemmeler, Bernard F, additional, Gilliland, Frank D, additional, Grazuleviciene, Regina, additional, Håberg, Siri E, additional, Herberth, Gunda, additional, Holland, Nina, additional, Hough, Amy, additional, Hu, Donglei, additional, Huen, Karen, additional, Hüls, Anke, additional, Jin, Jianping, additional, Julvez, Jordi, additional, Koletzko, Berthold V, additional, Koppelman, Gerard H, additional, Kull, Inger, additional, Lu, Xueling, additional, Maitre, Léa, additional, Mason, Dan, additional, Mélen, Erik, additional, Merid, Simon K, additional, Molloy, Peter L, additional, Mori, Trevor A, additional, Mulder, Rosa H, additional, Page, Christian M, additional, Richmond, Rebecca C, additional, Roder, Stefan, additional, Ross, Jason P, additional, Schellhas, Laura, additional, Sebert, Sylvain, additional, Sheppard, Dean, additional, Snieder, Harold, additional, Starling, Anne P, additional, Stein, Dan J, additional, Tindula, Gwen, additional, van IJzendoorn, Marinus H, additional, Vonk, Judith, additional, Walton, Esther, additional, Witonsky, Jonathan, additional, Xu, Cheng-Jian, additional, Yang, Ivana V, additional, Yousefi, Paul D, additional, Zar, Heather J, additional, Zenclussen, Ana C, additional, Zhang, Hongmei, additional, Tiemeier, Henning, additional, London, Stephanie J, additional, Felix, Janine F, additional, and Cecil, Charlotte, additional
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- 2024
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13. Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: Meta-analysis in six European population-based cohorts
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Alemany, Silvia, Avella-García, Claudia, Liew, Zeyan, García-Esteban, Raquel, Inoue, Kosuke, Cadman, Tim, López-Vicente, Mònica, González, Llúcia, Riaño Galán, Isolina, Andiarena, Ainara, Casas, Maribel, Margetaki, Katerina, Strandberg-Larsen, Katrine, Lawlor, Deborah A., El Marroun, Hanan, Tiemeier, Henning, Iñiguez, Carmen, Tardón, Adonina, Santa-Marina, Loreto, Júlvez, Jordi, Porta, Daniela, Chatzi, Leda, and Sunyer, Jordi
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- 2021
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14. Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation
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Sammallahti, Sara, Cortes Hidalgo, Andrea P., Tuominen, Samuli, Malmberg, Anni, Mulder, Rosa H., Brunst, Kelly J., Alemany, Silvia, McBride, Nancy S., Yousefi, Paul, Heiss, Jonathan A., McRae, Nia, Page, Christian M., Jin, Jianping, Pesce, Giancarlo, Caramaschi, Doretta, Rifas-Shiman, Sheryl L., Koen, Nastassja, Adams, Charleen D., Magnus, Maria C., Baïz, Nour, Ratanatharathorn, Andrew, Czamara, Darina, Håberg, Siri E., Colicino, Elena, Baccarelli, Andrea A., Cardenas, Andres, DeMeo, Dawn L., Lawlor, Deborah A., Relton, Caroline L., Felix, Janine F., van IJzendoorn, Marinus H., Bakermans-Kranenburg, Marian J., Kajantie, Eero, Räikkönen, Katri, Sunyer, Jordi, Sharp, Gemma C., Houtepen, Lotte C., Nohr, Ellen A., Sørensen, Thorkild I. A., Téllez-Rojo, Martha M., Wright, Robert O., Annesi-Maesano, Isabella, Wright, John, Hivert, Marie-France, Wright, Rosalind J., Zar, Heather J., Stein, Dan J., London, Stephanie J., Cecil, Charlotte A. M., Tiemeier, Henning, and Lahti, Jari
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- 2021
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15. Polygenic Risk Scores for Developmental Disorders, Neuromotor Functioning During Infancy, and Autistic Traits in Childhood
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Serdarevic, Fadila, Tiemeier, Henning, Jansen, Philip R., Alemany, Silvia, Xerxa, Yllza, Neumann, Alexander, Robinson, Elise, Hillegers, Manon H.J., Verhulst, Frank C., and Ghassabian, Akhgar
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- 2020
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16. Disentangling heterogeneity in Substance Use Disorders: Insights from Genome-Wide Polygenic Scores
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Vilar-Ribo, Laura, primary, Alemany, Silvia, additional, Cabana-Dominguez, Judit, additional, Llonga, Natalia, additional, Arribas, Lorena, additional, Grau-Lopez, Lara, additional, Daigre, Constanza, additional, Cormand, Bru, additional, Fernandez-Castillo, Noelia, additional, Ramos-Quiroga, Josep Antoni, additional, Soler Artigas, Maria, additional, and Ribases, Marta, additional
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- 2023
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17. Common Polygenic Variations for Psychiatric Disorders and Cognition in Relation to Brain Morphology in the General Pediatric Population
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Alemany, Silvia, Jansen, Philip R., Muetzel, Ryan L., Marques, Natália, El Marroun, Hanan, Jaddoe, Vincent W.V., Polderman, Tinca J.C., Tiemeier, Henning, Posthuma, Danielle, and White, Tonya
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- 2019
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18. F54. DISSECTING POLYGENIC RISK FOR NEURODEVELOPMENTAL DISORDERS BY EDUCATIONAL ATTAINMENT AND EXPLORING THEIR RELATIONSHIP WITH SCHOOL PERFORMANCE
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Ribasés, Marta, primary, Bosch, Rosa, additional, Alemany, Silvia, additional, Cabana-Domínguez, Judit, additional, Soler, María, additional, Llonga, Natalia, additional, Vilar, Laura, additional, Carabí, Pau, additional, Arribas, Lorena, additional, Español-Martín, Gemma, additional, Pagerols, Mireia, additional, Prat, Raquel, additional, Pagespetit, Elia, additional, Casas, Miquel, additional, and Ramos-Quiroga, Josep Antoni, additional
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- 2023
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19. F58. INDIVIDUAL AND COMBINED EFFECTS OF POLYGENIC AND ENVIRONMENTAL RISK SCORES ON ATTENTION DEFICIT AND HYPERACTIVITY DISORDER MEASURES AMONG SCHOOL CHILDREN
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Alemany, Silvia, primary, Soler-Artigas, María, additional, Cabana-Domínguez, Judit, additional, Bosch, Rosa, additional, Vilar-Ribó, Laura, additional, Llonga, Natalia, additional, Carabí, Pau, additional, Ramos-Quiroga, Josep-Antoni, additional, Pagerols, Mireia, additional, Prat, Raquel, additional, Pagespetit, Elia, additional, Puigbo, Julia, additional, Español-Martín, Gemma, additional, Casas, Miquel, additional, and Ribasés, Marta, additional
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- 2023
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20. T12. EXPLORING THE BEHAVIORAL AND EMOTIONAL MANIFESTATION OF POLYGENIC RISK FOR PSYCHIATRIC DISORDERS AMONG SCHOOL CHILDREN
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Alemany, Silvia, primary, Soler, María, additional, Cabana-Domínguez, Judit, additional, Bosch, Rosa, additional, Vilar-Ribó, Laura, additional, Llonga, Natalia, additional, Carabí, Pau, additional, Ramos-Quiroga, Josep-Antoni, additional, Pagerols, Mireia, additional, Prat, Raquel, additional, Pagespetit, Elia, additional, Puigbo, Julia, additional, Español-Martín, Gemma, additional, Casas, Miquel, additional, and Ribasés, Marta, additional
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- 2023
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21. Strategies for integrated analysis in imaging genetics studies
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Vilor-Tejedor, Natàlia, Alemany, Silvia, Cáceres, Alejandro, Bustamante, Mariona, Pujol, Jesús, Sunyer, Jordi, and González, Juan R.
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- 2018
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22. Independent Multiple Factor Association Analysis for Multiblock Data in Imaging Genetics
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Vilor-Tejedor, Natalia, Ikram, Mohammad Arfan, Roshchupkin, Gennady V., Cáceres, Alejandro, Alemany, Silvia, Vernooij, Meike W., Niessen, Wiro J., van Duijn, Cornelia M., Sunyer, Jordi, Adams, Hieab H., and González, Juan R.
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- 2019
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23. Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis
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Neumann, Alexander, Walton, Esther, Alemany, Silvia, Cecil, Charlotte, González, Juan Ramon, Jima, Dereje D., Lahti, Jari, Tuominen, Samuli T., Barker, Edward D., Binder, Elisabeth, Caramaschi, Doretta, Carracedo, Ángel, Czamara, Darina, Evandt, Jorunn, Felix, Janine F., Fuemmeler, Bernard F., Gutzkow, Kristine B., Hoyo, Cathrine, Julvez, Jordi, Kajantie, Eero, Laivuori, Hannele, Maguire, Rachel, Maitre, Léa, Murphy, Susan K., Murcia, Mario, Villa, Pia M., Sharp, Gemma, Sunyer, Jordi, Raikkönen, Katri, Bakermans-Kranenburg, Marian, IJzendoorn, Marinus van, Guxens, Mònica, Relton, Caroline L., and Tiemeier, Henning
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- 2020
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24. DNA methylation at birth and fine motor ability in childhood: an epigenome-wide association study with replication
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Serdarevic, Fadila, primary, Luo, Mannan, additional, Karabegović, Irma, additional, Binter, Anne-Claire, additional, Alemany, Silvia, additional, Mutzel, Ryan, additional, Guxens, Monica, additional, Bustamante, Mariona, additional, Hajdarpasic, Aida, additional, White, Tonya, additional, Felix, Janine F, additional, Cecil, Charlotte A.M., additional, and Tiemeier, Henning, additional
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- 2023
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25. Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new genetic hits
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Alemany, Silvia, primary, Soler-Artigas, Maria, additional, Cabana-Dominguez, Judit, additional, Fakhreddine, Dana Salim, additional, Llonga, Natalia, additional, Vilar-Ribo, Laura, additional, Rodriguez-Urrutia, Amanda, additional, Palacio, Judit, additional, Gonzalez-Castro, Ana Maria, additional, Lobo, Beatriz, additional, Alonso-Cotoner, Carmen, additional, Simren, Magnus, additional, Santos, Javier, additional, Ramos-Quiroga, Josep Antoni, additional, and Ribases, Marta, additional
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- 2023
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26. DNA methylation and general psychopathology in childhood:an epigenome-wide meta-analysis from the PACE consortium
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Rijlaarsdam, Jolien, Cosin-Tomas, Marta, Schellhas, Laura, Abrishamcar, Sarina, Malmberg, Anni, Neumann, Alexander, Felix, Janine F., Sunyer, Jordi, Gutzkow, Kristine B., Grazuleviciene, Regina, Wright, John, Kampouri, Mariza, Zar, Heather J., Stein, Dan J., Heinonen, Kati, Räikkönen, Katri, Lahti, Jari, Hüls, Anke, Caramaschi, Doretta, Alemany, Silvia, Cecil, Charlotte A.M., Rijlaarsdam, Jolien, Cosin-Tomas, Marta, Schellhas, Laura, Abrishamcar, Sarina, Malmberg, Anni, Neumann, Alexander, Felix, Janine F., Sunyer, Jordi, Gutzkow, Kristine B., Grazuleviciene, Regina, Wright, John, Kampouri, Mariza, Zar, Heather J., Stein, Dan J., Heinonen, Kati, Räikkönen, Katri, Lahti, Jari, Hüls, Anke, Caramaschi, Doretta, Alemany, Silvia, and Cecil, Charlotte A.M.
- Abstract
The general psychopathology factor (GPF) has been proposed as a way to capture variance shared between psychiatric symptoms. Despite a growing body of evidence showing both genetic and environmental influences on GPF, the biological mechanisms underlying these influences remain unclear. In the current study, we conducted epigenome-wide meta-analyses to identify both probe- and region-level associations of DNA methylation (DNAm) with school-age general psychopathology in six cohorts from the Pregnancy And Childhood Epigenetics (PACE) Consortium. DNAm was examined both at birth (cord blood; prospective analysis) and during school-age (peripheral whole blood; cross-sectional analysis) in total samples of N = 2178 and N = 2190, respectively. At school-age, we identified one probe (cg11945228) located in the Bromodomain-containing protein 2 gene (BRD2) that negatively associated with GPF (p = 8.58 × 10–8). We also identified a significant differentially methylated region (DMR) at school-age (p = 1.63 × 10–8), implicating the SHC Adaptor Protein 4 (SHC4) gene and the EP300-interacting inhibitor of differentiation 1 (EID1) gene that have been previously implicated in multiple types of psychiatric disorders in adulthood, including obsessive compulsive disorder, schizophrenia, and major depressive disorder. In contrast, no prospective associations were identified with DNAm at birth. Taken together, results of this study revealed some evidence of an association between DNAm at school-age and GPF. Future research with larger samples is needed to further assess DNAm variation associated with GPF.
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- 2023
27. DNA Methylation at Birth and Fine Motor Ability in Childhood:An Epigenome-wide Association Study with Replication
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Serdarevic, Fadila, Luo, Mannan, Karabegovic, Irma, Binter, Anne Claire, Alemany, Silvia, Mutzel, Ryan, Guxens Junyent, Monica, Bustamante, Mariona, Hajdarpasic, Aida, White, Tonya, Felix, Janine, Cecil, Charlotte, Tiemeier, Henning, Serdarevic, Fadila, Luo, Mannan, Karabegovic, Irma, Binter, Anne Claire, Alemany, Silvia, Mutzel, Ryan, Guxens Junyent, Monica, Bustamante, Mariona, Hajdarpasic, Aida, White, Tonya, Felix, Janine, Cecil, Charlotte, and Tiemeier, Henning
- Abstract
Lower fine motor performance in childhood has been associated with poorer cognitive development and neurodevelopmental conditions such as autism spectrum disorder, yet, biological underpinnings remain unclear. DNA methylation (DNAm), an essential process for healthy neurodevelopment, is a key molecular system of interest. In this study, we conducted the first epigenome-wide association study of neonatal DNAm with childhood fine motor ability and further examined the replicability of epigenetic markers in an independent cohort. The discovery study was embedded in Generation R, a large population-based prospective cohort, including a subsample of 924 ~ 1026 European-ancestry singletons with available data on DNAm in cord blood and fine motor ability at a mean (SD) age of 9.8 (0.4) years. Fine motor ability was measured using a finger-tapping test (3 subtests including left-, right-hand and bimanual), one of the most frequently used neuropsychological instruments of fine motor function. The replication study comprised 326 children with a mean (SD) age of 6.8 (0.4) years from an independent cohort, the INfancia Medio Ambiente (INMA) study. Four CpG sites at birth were prospectively associated with childhood fine motor ability after genome-wide correction. Of these, one CpG (cg07783800 in GNG4) was replicated in INMA, showing that lower levels of methylation at this site were associated with lower fine motor performance in both cohorts. GNG4 is highly expressed in the brain and has been implicated in cognitive decline. Our findings support a prospective, reproducible association between DNAm at birth and fine motor ability in childhood, pointing to GNG4 methylation at birth as a potential biomarker of fine motor ability.
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- 2023
28. Air pollution exposure during pregnancy and childhood, APOE ε4 status and Alzheimer polygenic risk score, and brain structural morphology in preadolescents
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Essers, Esmée, primary, Binter, Anne-Claire, additional, Neumann, Alexander, additional, White, Tonya, additional, Alemany, Silvia, additional, and Guxens, Mònica, additional
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- 2023
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29. DNA methylation and general psychopathology in childhood: an epigenome-wide meta-analysis from the PACE consortium
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Rijlaarsdam, Jolien, primary, Cosin-Tomas, Marta, additional, Schellhas, Laura, additional, Abrishamcar, Sarina, additional, Malmberg, Anni, additional, Neumann, Alexander, additional, Felix, Janine F., additional, Sunyer, Jordi, additional, Gutzkow, Kristine B., additional, Grazuleviciene, Regina, additional, Wright, John, additional, Kampouri, Mariza, additional, Zar, Heather J., additional, Stein, Dan J., additional, Heinonen, Kati, additional, Räikkönen, Katri, additional, Lahti, Jari, additional, Hüls, Anke, additional, Caramaschi, Doretta, additional, Alemany, Silvia, additional, and Cecil, Charlotte A. M., additional
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- 2022
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30. T118. PRS-PHEWAS OF PSYCHIATRIC/BEHAVIORAL TRAITS TO DISENTANGLE CLINICAL HETEROGENEITY IN SUBSTANCE USE DISORDERS
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Vilar-Ribó, Laura, primary, Alemany, Silvia, additional, Cabana-Domínguez, Judit, additional, Arribas, Lorena, additional, Llonga, Natalia, additional, Daigre, Constanza, additional, Grau-López, Lara, additional, Ramos-Quiroga, Josep Antoni, additional, Artigas, Maria Soler, additional, and Ribasés, Marta, additional
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- 2022
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31. F1.INTEGRATED ANALYSIS OF DNA METHYLATION AND GENE EXPRESSION IN ATTENTION-DEFICIT/ HYPERACTIVITY DISORDER
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Cabana-Domínguez, Judit, primary, Arribas, Lorena, additional, Alemany, Silvia, additional, Vilar-Ribó, Laura, additional, Llonga, Natalia, additional, Fadeuilhe, Christian, additional, Corrales, Montse, additional, Richarte, Vanessa, additional, Ramos-Quiroga, Josep Antoni, additional, Artigas, María Soler, additional, and Ribasés, Marta, additional
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- 2022
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32. Air Pollution Exposure during Pregnancy and Childhood, APOE ε4 Status and Polygenic Risk Score for Alzheimer’s Disease, and Brain Structural Morphology in Preadolescents
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Essers, Esmée, primary, Binter, Anne-Claire, additional, Neumann, Alexander, additional, White, Tonya, additional, Alemany, Silvia, additional, and Guxens, Mònica, additional
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- 2022
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33. A genome-wide association study of total child psychiatric problems scores
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Neumann, Alexander, primary, Nolte, Ilja M., additional, Pappa, Irene, additional, Ahluwalia, Tarunveer S., additional, Pettersson, Erik, additional, Rodriguez, Alina, additional, Whitehouse, Andrew, additional, van Beijsterveldt, Catharina E. M., additional, Benyamin, Beben, additional, Hammerschlag, Anke R., additional, Helmer, Quinta, additional, Karhunen, Ville, additional, Krapohl, Eva, additional, Lu, Yi, additional, van der Most, Peter J., additional, Palviainen, Teemu, additional, St Pourcain, Beate, additional, Seppälä, Ilkka, additional, Suarez, Anna, additional, Vilor-Tejedor, Natalia, additional, Tiesler, Carla M. T., additional, Wang, Carol, additional, Wills, Amanda, additional, Zhou, Ang, additional, Alemany, Silvia, additional, Bisgaard, Hans, additional, Bønnelykke, Klaus, additional, Davies, Gareth E., additional, Hakulinen, Christian, additional, Henders, Anjali K., additional, Hyppönen, Elina, additional, Stokholm, Jakob, additional, Bartels, Meike, additional, Hottenga, Jouke-Jan, additional, Heinrich, Joachim, additional, Hewitt, John, additional, Keltikangas-Järvinen, Liisa, additional, Korhonen, Tellervo, additional, Kaprio, Jaakko, additional, Lahti, Jari, additional, Lahti-Pulkkinen, Marius, additional, Lehtimäki, Terho, additional, Middeldorp, Christel M., additional, Najman, Jackob M., additional, Pennell, Craig, additional, Power, Chris, additional, Oldehinkel, Albertine J., additional, Plomin, Robert, additional, Räikkönen, Katri, additional, Raitakari, Olli T., additional, Rimfeld, Kaili, additional, Sass, Lærke, additional, Snieder, Harold, additional, Standl, Marie, additional, Sunyer, Jordi, additional, Williams, Gail M., additional, Bakermans-Kranenburg, Marian J., additional, Boomsma, Dorret I., additional, van IJzendoorn, Marinus H., additional, Hartman, Catharina A., additional, and Tiemeier, Henning, additional
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- 2022
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34. P466. Genetic Signature of Brain Dynamic Connectivity Patterns Associated With Obsessive-Compulsive Symptoms in Healthy Children
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Suñol, Maria, primary, Alemany, Silvia, additional, Bustamante, Mariona, additional, Diez, Ibai, additional, Contreras-Rodríguez, Oren, additional, Laudo, Berta, additional, Macià, Dídac, additional, Martínez-Vilavella, Gerard, additional, Martínez-Zalacaín, Ignacio, additional, Menchón, José Manuel, additional, Pujol, Jesús, additional, Sunyer, Jordi, additional, Sepulcre, Jorge, additional, and Soriano-Mas, Carles, additional
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- 2022
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35. Regional gray matter reductions are associated with genetic liability for anxiety and depression: An MRI twin study
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Alemany, Silvia, Mas, Alex, Goldberg, Ximena, Falcón, Carles, Fatjó-Vilas, Mar, Arias, Bárbara, Bargalló, Núria, Nenadic, Igor, Gastó, Cristóbal, and Fañanás, Lourdes
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- 2013
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36. Gene–environment interaction on cognition: A twin study of childhood maltreatment and COMT variability
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Goldberg, Ximena, Fatjó-Vilas, Mar, Alemany, Silvia, Nenadic, Igor, Gastó, Cristobal, and Fañanás, Lourdes
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- 2013
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37. Polygenic risk for ADHD and ASD and their relation with cognitive measures in school children
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Aguilar-Lacasaña, Sofía, Vilor-Tejedor, Natàlia, Jansen, Philip R., López-Vicente, Mònica, Bustamante, Mariona, Burgaleta, Miguel, Sunyer, Jordi, Alemany, Silvia, Aguilar-Lacasaña, Sofía, Vilor-Tejedor, Natàlia, Jansen, Philip R., López-Vicente, Mònica, Bustamante, Mariona, Burgaleta, Miguel, Sunyer, Jordi, and Alemany, Silvia
- Abstract
Background Attention deficit and hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are child-onset neurodevelopmental disorders frequently accompanied by cognitive difficulties. In the current study, we aim to examine the genetic overlap between ADHD and ASD and cognitive measures of working memory (WM) and attention performance among schoolchildren using a polygenic risk approach. Methods A total of 1667 children from a population-based cohort aged 7-11 years with data available on genetics and cognition were included in the analyses. Polygenic risk scores (PRS) were calculated for ADHD and ASD using results from the largest GWAS to date (N = 55 374 and N = 46 351, respectively). The cognitive outcomes included verbal and numerical WM and the standard error of hit reaction time (HRTSE) as a measure of attention performance. These outcomes were repeatedly assessed over 1-year period using computerized version of the Attention Network Test and n-back task. Associations were estimated using linear mixed-effects models. Results Higher polygenic risk for ADHD was associated with lower WM performance at baseline time but not over time. These findings remained significant after adjusting by multiple testing and excluding individuals with an ADHD diagnosis but were limited to boys. PRS for ASD was only nominally associated with an increased improvement on verbal WM over time, although this association did not survive multiple testing correction. No associations were observed for HRTSE. Conclusions Common genetic variants related to ADHD may contribute to worse WM performance among schoolchildren from the general population but not to the subsequent cognitive-developmental trajectory assessed over 1-year period.
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- 2022
38. A genome-wide association study of total child psychiatric problems scores
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Neumann, Alexander, Nolte, Ilja M, Pappa, Irene, Ahluwalia, Tarunveer S., Pettersson, Erik, Rodriguez, Alina, Whitehouse, Andrew, van Beijsterveldt, Catharina E. M., Benyamin, Beben, Hammerschlag, Anke R., Helmer, Quinta, Karhunen, Ville, Krapohl, Eva, Lu, Yi, van der Most, Peter J., Palviainen, Teemu, Pourcain, Beate St, Seppälä, Ilkka, Suarez, Anna, Vilor-Tejedor, Natalia, Tiesler, Carla M. T., Wang, Carol, Wills, Amanda, Zhou, Ang, Alemany, Silvia, Bisgaard, Hans, Bønnelykke, Klaus, Davies, Gareth E., Hakulinen, Christian, Henders, Anjali K., Hyppönen, Elina, Stokholm, Jakob, Bartels, Meike, Hottenga, Jouke-Jan, Heinrich, Joachim, Hewitt, John, Keltikangas-Järvinen, Liisa, Korhonen, Tellervo, Kaprio, Jaakko, Lahti, Jari, Lahti-Pulkkinen, Marius, Lehtimäki, Terho, Middeldorp, Christel M., Najman, Jackob M., Pennell, Craig, Power, Chris, Oldehinkel, Albertine J., Plomin, Robert, Räikkönen, Katri, Raitakari, Olli T., Rimfeld, Kaili, Sass, Lærke, Snieder, Harold, Standl, Marie, Sunyer, Jordi, Williams, Gail M., Bakermans-Kranenburg, Marian J., Boomsma, Dorret I., van IJzendoorn, Marinus H., Hartman, Catharina A., Tiemeier, Henning, Neumann, Alexander, Nolte, Ilja M, Pappa, Irene, Ahluwalia, Tarunveer S., Pettersson, Erik, Rodriguez, Alina, Whitehouse, Andrew, van Beijsterveldt, Catharina E. M., Benyamin, Beben, Hammerschlag, Anke R., Helmer, Quinta, Karhunen, Ville, Krapohl, Eva, Lu, Yi, van der Most, Peter J., Palviainen, Teemu, Pourcain, Beate St, Seppälä, Ilkka, Suarez, Anna, Vilor-Tejedor, Natalia, Tiesler, Carla M. T., Wang, Carol, Wills, Amanda, Zhou, Ang, Alemany, Silvia, Bisgaard, Hans, Bønnelykke, Klaus, Davies, Gareth E., Hakulinen, Christian, Henders, Anjali K., Hyppönen, Elina, Stokholm, Jakob, Bartels, Meike, Hottenga, Jouke-Jan, Heinrich, Joachim, Hewitt, John, Keltikangas-Järvinen, Liisa, Korhonen, Tellervo, Kaprio, Jaakko, Lahti, Jari, Lahti-Pulkkinen, Marius, Lehtimäki, Terho, Middeldorp, Christel M., Najman, Jackob M., Pennell, Craig, Power, Chris, Oldehinkel, Albertine J., Plomin, Robert, Räikkönen, Katri, Raitakari, Olli T., Rimfeld, Kaili, Sass, Lærke, Snieder, Harold, Standl, Marie, Sunyer, Jordi, Williams, Gail M., Bakermans-Kranenburg, Marian J., Boomsma, Dorret I., van IJzendoorn, Marinus H., Hartman, Catharina A., and Tiemeier, Henning
- Abstract
Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric problem score. We analyzed 6,844,199 common SNPs in 38,418 school-aged children from 20 population-based cohorts participating in the EAGLE consortium. The SNP heritability of total psychiatric problems was 5.4% (SE = 0.01) and two loci reached genome-wide significance: rs10767094 and rs202005905. We also observed an association of SBF2, a gene associated with neuroticism in previous GWAS, with total psychiatric problems. The genetic effects underlying the total score were shared with common psychiatric disorders only (attention-deficit/hyperactivity disorder, anxiety, depression, insomnia) (rG > 0.49), but not with autism or the less common adult disorders (schizophrenia, bipolar disorder, or eating disorders) (rG < 0.01). Importantly, the total psychiatric problem score also showed at least a moderate genetic correlation with intelligence, educational attainment, wellbeing, smoking, and body fat (rG > 0.29). The results suggest that many common genetic variants are associated with childhood psychiatric symptoms and related phenotypes in general instead of with specific symptoms. Further research is needed to establish causality and pleiotropic mechanisms between related traits.
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- 2022
39. Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms
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Jami, Eshim S., Hammerschlag, Anke R., Ip, Hill F., Allegrini, Andrea G., Benyamin, Beben, Border, Richard, Diemer, Elizabeth W., Jiang, Chang, Karhunen, Ville, Lu, Yi, Lu, Qing, Mallard, Travis T., Mishra, Pashupati P., Nolte, Ilja M., Palviainen, Teemu, Peterson, Roseann E., Sallis, Hannah M., Shabalin, Andrey A., Tate, Ashley E., Thiering, Elisabeth, Vilor-Tejedor, Natàlia, Wang, Carol, Zhou, Ang, Adkins, Daniel E., Alemany, Silvia, Ask, Helga, Chen, Qi, Corley, Robin P., Ehli, Erik A., Evans, Luke M., Havdahl, Alexandra, Hagenbeek, Fiona A., Hakulinen, Christian, Henders, Anjali K., Hottenga, Jouke Jan, Korhonen, Tellervo, Mamun, Abdullah, Marrington, Shelby, Neumann, Alexander, Rimfeld, Kaili, Rivadeneira, Fernando, Silberg, Judy L., van Beijsterveldt, Catharina E., Vuoksimaa, Eero, Whipp, Alyce M., Tong, Xiaoran, Andreassen, Ole A., Boomsma, Dorret I., Brown, Sandra A., Burt, S. Alexandra, Copeland, William, Dick, Danielle M., Harden, K. Paige, Harris, Kathleen Mullan, Hartman, Catharina A., Heinrich, Joachim, Hewitt, John K., Hopfer, Christian, Hypponen, Elina, Jarvelin, Marjo Riitta, Kaprio, Jaakko, Keltikangas-Järvinen, Liisa, Klump, Kelly L., Krauter, Kenneth, Kuja-Halkola, Ralf, Larsson, Henrik, Lehtimäki, Terho, Lichtenstein, Paul, Lundström, Sebastian, Maes, Hermine H., Magnus, Per, Munafò, Marcus R., Najman, Jake M., Njølstad, Pål R., Oldehinkel, Albertine J., Pennell, Craig E., Plomin, Robert, Reichborn-Kjennerud, Ted, Reynolds, Chandra, Rose, Richard J., Smolen, Andrew, Snieder, Harold, Stallings, Michael, Standl, Marie, Sunyer, Jordi, Tiemeier, Henning, Wadsworth, Sally J., Wall, Tamara L., Whitehouse, Andrew J.O., Williams, Gail M., Ystrøm, Eivind, Nivard, Michel G., Bartels, Meike, Middeldorp, Christel M., Jami, Eshim S., Hammerschlag, Anke R., Ip, Hill F., Allegrini, Andrea G., Benyamin, Beben, Border, Richard, Diemer, Elizabeth W., Jiang, Chang, Karhunen, Ville, Lu, Yi, Lu, Qing, Mallard, Travis T., Mishra, Pashupati P., Nolte, Ilja M., Palviainen, Teemu, Peterson, Roseann E., Sallis, Hannah M., Shabalin, Andrey A., Tate, Ashley E., Thiering, Elisabeth, Vilor-Tejedor, Natàlia, Wang, Carol, Zhou, Ang, Adkins, Daniel E., Alemany, Silvia, Ask, Helga, Chen, Qi, Corley, Robin P., Ehli, Erik A., Evans, Luke M., Havdahl, Alexandra, Hagenbeek, Fiona A., Hakulinen, Christian, Henders, Anjali K., Hottenga, Jouke Jan, Korhonen, Tellervo, Mamun, Abdullah, Marrington, Shelby, Neumann, Alexander, Rimfeld, Kaili, Rivadeneira, Fernando, Silberg, Judy L., van Beijsterveldt, Catharina E., Vuoksimaa, Eero, Whipp, Alyce M., Tong, Xiaoran, Andreassen, Ole A., Boomsma, Dorret I., Brown, Sandra A., Burt, S. Alexandra, Copeland, William, Dick, Danielle M., Harden, K. Paige, Harris, Kathleen Mullan, Hartman, Catharina A., Heinrich, Joachim, Hewitt, John K., Hopfer, Christian, Hypponen, Elina, Jarvelin, Marjo Riitta, Kaprio, Jaakko, Keltikangas-Järvinen, Liisa, Klump, Kelly L., Krauter, Kenneth, Kuja-Halkola, Ralf, Larsson, Henrik, Lehtimäki, Terho, Lichtenstein, Paul, Lundström, Sebastian, Maes, Hermine H., Magnus, Per, Munafò, Marcus R., Najman, Jake M., Njølstad, Pål R., Oldehinkel, Albertine J., Pennell, Craig E., Plomin, Robert, Reichborn-Kjennerud, Ted, Reynolds, Chandra, Rose, Richard J., Smolen, Andrew, Snieder, Harold, Stallings, Michael, Standl, Marie, Sunyer, Jordi, Tiemeier, Henning, Wadsworth, Sally J., Wall, Tamara L., Whitehouse, Andrew J.O., Williams, Gail M., Ystrøm, Eivind, Nivard, Michel G., Bartels, Meike, and Middeldorp, Christel M.
- Abstract
Objective: To investigate the genetic architecture of internalizing symptoms in childhood and adolescence. Method: In 22 cohorts, multiple univariate genome-wide association studies (GWASs) were performed using repeated assessments of internalizing symptoms, in a total of 64,561 children and adolescents between 3 and 18 years of age. Results were aggregated in meta-analyses that accounted for sample overlap, first using all available data, and then using subsets of measurements grouped by rater, age, and instrument. Results: The meta-analysis of overall internalizing symptoms (INToverall) detected no genome-wide significant hits and showed low single nucleotide polymorphism (SNP) heritability (1.66%, 95% CI = 0.84-2.48%, neffective = 132,260). Stratified analyses indicated rater-based heterogeneity in genetic effects, with self-reported internalizing symptoms showing the highest heritability (5.63%, 95% CI = 3.08%-8.18%). The contribution of additive genetic effects on internalizing symptoms appeared to be stable over age, with overlapping estimates of SNP heritability from early childhood to adolescence. Genetic correlations were observed with adult anxiety, depression, and the well-being spectrum (|rg| > 0.70), as well as with insomnia, loneliness, attention-deficit/hyperactivity disorder, autism, and childhood aggression (range |rg| = 0.42-0.60), whereas there were no robust associations with schizophrenia, bipolar disorder, obsessive-compulsive disorder, or anorexia nervosa. Conclusion: Genetic correlations indicate that childhood and adolescent internalizing symptoms share substantial genetic vulnerabilities with adult internalizing disorders and other childhood psychiatric traits, which could partially explain both the persistence of internalizing symptoms over time and the high comorbidity among childhood psychiatric traits. Reducing phenotypic heterogeneity in childhood samples will be key in paving the way t
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- 2022
40. Air Pollution Exposure During Pregnancy and Childhood, Apoe Ε4 Status and Alzheimer Polygenic Risk Score, and Brain Structural Morphology in Preadolescents
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Essers, Esmée, primary, Binter, Anne-Claire, additional, Neumann, Alexander, additional, Alemany, Silvia, additional, White, Tonya, additional, and Guxens, Mònica, additional
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- 2022
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41. Associations between air pollution and biomarkers of Alzheimer’s disease in cognitively unimpaired individuals
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Alemany, Silvia, primary, Crous-Bou, Marta, additional, Vilor-Tejedor, Natalia, additional, Milà-Alomà, Marta, additional, Suárez-Calvet, Marc, additional, Salvadó, Gemma, additional, Cirach, Marta, additional, Arenaza-Urquijo, Eider M., additional, Sanchez-Benavides, Gonzalo, additional, Grau-Rivera, Oriol, additional, Minguillon, Carolina, additional, Fauria, Karine, additional, Kollmorgen, Gwendlyn, additional, Domingo Gispert, Juan, additional, Gascón, Mireia, additional, Nieuwenhuijsen, Mark, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Sunyer, Jordi, additional, and Luis Molinuevo, José, additional
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- 2021
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42. Exposición temprana a paracetamol y síntomas de déficit de atención e hiperactividad en la infancia: metaanálisis en seis cohortes de nacimento europeas
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Alemany, Silvia, García-Esteban, Raquel, Casas, Maribel, Júlvez, Jordi, Avella-Garcia, Claudia, López-Vicente, Mònica, Riaño Galán, Isolina, Tardón, Adonina, Andiarena, Ainara, Santa-Marina, Loreto, González, Llúcia, Rodríguez-Bernal, Clara L, Íñiguez, Carmen, Inoue, Kosuke, Liew, Zeyan, Strandberg- Larsen, Katrine, Taylor, Michelle, Cadman, Tim, Lawlor, Deborah, Porta, Daniela, Tiemeier, Hening, El-Marroun, Hannan, Margetaki, Aikaterini, Roumeliotaki, Theano, Chatzi, Leda, and Sunyer, Jordi
- Abstract
Psicosomàtica y Psiquiatría, Núm. 11 (2019): octubre-noviembre-diciembre
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- 2021
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43. TU4. COMPREHENSIVE ANALYSIS OF OMICS DATA IDENTIFIED ADHD RELEVANT GENE NETWORKS
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Cabana-Domínguez, Judit, primary, Artigas, María Soler, additional, Arribas, Lorena, additional, Vilar-Ribó, Laura, additional, Alemany, Silvia, additional, Llonga, Natalia, additional, Fadeuilhe, Christian, additional, Corrales, Montse, additional, Richarte, Vanessa, additional, Ramos-Quiroga, Josep Antoni, additional, and Ribases, Marta, additional
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- 2021
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44. New suggestive genetic loci and biological pathways for attention function in adult attention-deficit/hyperactivity disorder
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Alemany, Silvia, Ribasés, Marta, Vilor-Tejedor, Natàlia, Bustamante, Mariona, Sánchez-Mora, Cristina, Bosch, Rosa, Richarte, Vanesa, Cormand, Bru, Casas, Miguel, Ramos-Quiroga, Josep A., and Sunyer, Jordi
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- 2015
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45. Twin-based study of the complex interplay between childhood maltreatment, socioeconomic status and adult memory
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Goldberg, Ximena, Alemany, Silvia, Fatjó-Vilas, Mar, González-Ortega, Itxaso, González-Pinto, Ana, Cuesta, Manuel J., and Fañanás, Lourdes
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- 2013
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46. Brain morphology, autistic traits, and polygenic risk for autism: A population‐based neuroimaging study
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Alemany, Silvia, primary, Blok, Elisabet, additional, Jansen, Philip R., additional, Muetzel, Ryan L., additional, and White, Tonya, additional
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- 2021
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47. DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan
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van Dongen, Jenny, Hagenbeek, Fiona A., Suderman, Matthew, Roetman, Peter J., Sugden, Karen, Chiocchetti, Andreas G., Ismail, Khadeeja, Mulder, Rosa H., Hafferty, Jonathan D., Adams, Mark J., Walker, Rosie M., Morris, Stewart W., Lahti, Jari, Küpers, Leanne K., Escaramis, Georgia, Alemany, Silvia, Jan Bonder, Marc, Meijer, Mandy, Ip, Hill F., Jansen, Rick, Baselmans, Bart M. L., Parmar, Priyanka, Lowry, Estelle, Streit, Fabian, Sirignano, Lea, Send, Tabea S., Frank, Josef, Jylhävä, Juulia, Wang, Yunzhang, Mishra, Pashupati Prasad, Colins, Olivier F., Corcoran, David L., Poulton, Richie, Mill, Jonathan, Hannon, Eilis, Arseneault, Louise, Korhonen, Tellervo, Vuoksimaa, Eero, Felix, Janine F., Bakermans-Kranenburg, Marian J., Campbell, Archie, Czamara, Darina, Binder, Elisabeth, Corpeleijn, Eva, Gonzalez, Juan R., Grazuleviciene, Regina, Gutzkow, Kristine B., Evandt, Jorunn, Vafeiadi, Marina, Klein, Marieke, van der Meer, Dennis, Ligthart, Lannie, Heijmans, Bastiaan T., ’t Hoen, Peter A. C., van Meurs, Joyce, Franke, Lude, Boomsma, Dorret I., Pool, René, Hottenga, Jouke J., van Greevenbroek, Marleen M. J., Stehouwer, Coen D. A., van der Kallen, Carla J. H., Schalkwijk, Casper G., Wijmenga, Cisca, Zhernakova, Sasha, Tigchelaar, Ettje F., Slagboom, P. Eline, Beekman, Marian, Deelen, Joris, van Heemst, Diana, Veldink, Jan H., van den Berg, Leonard H., van Duijn, Cornelia M., Hofman, Bert A., Isaacs, Aaron, Uitterlinden, André G., Jhamai, P. Mila, Verbiest, Michael, Suchiman, H. Eka D., Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Iterson, Maarten, van Galen, Michiel, Bot, Jan, Zhernakova, Dasha V., van ’t Hof, Peter, Deelen, Patrick, Nooren, Irene, Moed, Matthijs, Vermaat, Martijn, Luijk, René, van Dijk, Freerk, Arindrarto, Wibowo, Kielbasa, Szymon M., Swertz, Morris A., van Zwet, Erik. W., ’t Hoen, Peter-Bram, Kluft, Cornelis, Davies, Gareth E., Hakulinen, Christian, Keltikangas-Järvinen, Liisa, Franke, Barbara, Freitag, Christine M., Konrad, Kerstin, Hervas, Amaia, Fernández-Rivas, Aranzazu, Vetro, Agnes, Raitakari, Olli, Lehtimäki, Terho, Vermeiren, Robert, Strandberg, Timo, Räikkönen, Katri, Snieder, Harold, Witt, Stephanie H., Deuschle, Michael, Pedersen, Nancy L., Hägg, Sara, Sunyer, Jordi, Kaprio, Jaakko, Ollikainen, Miina, Moffitt, Terrie E., Tiemeier, Henning, van IJzendoorn, Marinus H., Relton, Caroline, Vrijheid, Martine, Sebert, Sylvain, Jarvelin, Marjo-Riitta, Caspi, Avshalom, Evans, Kathryn L., McIntosh, Andrew M., Bartels, Meike, Child and Adolescent Psychiatry / Psychology, Pediatrics, Internal Medicine, Urology, Epidemiology, Orthopedics and Sports Medicine, Clinical Child and Family Studies, van der Kallen, Carla J. H., Schalkwijk, Casper G., Wijmenga, Cisca, Franke, Lude, Zhernakova, Sasha, Tigchelaar, Ettje F., Slagboom, P. Eline, Beekman, Marian, Deelen, Joris, van Heemst, Diana, Veldink, Jan H., van den Berg, Leonard H., van Duijn, Cornelia M., Hofman, Bert A., Isaacs, Aaron, Uitterlinden, André G., van Meurs, Joyce, Jhamai, P. Mila, Verbiest, Michael, Suchiman, H. Eka D., Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Iterson, Maarten, van Galen, Michiel, Bot, Jan, Zhernakova, Dasha V., Jansen, Rick, van 't Hof, Peter, Deelen, Patrick, Nooren, Irene, 't Hoen, Peter A. C., Heijmans, Bastiaan T., Moed, Matthijs, Vermaat, Martijn, Luijk, René, Jan Bonder, Marc, van Dijk, Freerk, Arindrarto, Wibowo, Kielbasa, Szymon M., Swertz, Morris A., van Zwet, Erik W., 't Hoen, Peter-Bram, Boomsma, Dorret I., Pool, René, van Dongen, Jenny, Hottenga, Jouke J., van Greevenbroek, Marleen M. J., Stehouwer, Coen D. A., Institute for Molecular Medicine Finland, University of Helsinki, Doctoral Programme in Cognition, Learning, Instruction and Communication, Department of Psychology and Logopedics, Faculty of Medicine, Tellervo Korhonen / Principal Investigator, Genetic Epidemiology, Faculty Common Matters (Faculty of Medicine), Cognitive and Brain Aging, Helsinki Inequality Initiative (INEQ), Psychosocial factors and health, Faculty Common Matters (Faculty of Education), Medicum, HUS Internal Medicine and Rehabilitation, Timo Strandberg / Principal Investigator, Department of Medicine, Clinicum, Geriatrian yksikkö, Reproductive Origins of Adult Health and Disease (ROAHD), Life Course Epidemiology (LCE), Stem Cell Aging Leukemia and Lymphoma (SALL), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, Pediatric surgery, APH - Mental Health, Amsterdam Reproduction & Development (AR&D), APH - Personalized Medicine, Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Methodology, Tampere University, Health Sciences, Department of Clinical Chemistry, Clinical Medicine, RS: MHeNs - R2 - Mental Health, and Psychiatrie & Neuropsychologie
- Subjects
0301 basic medicine ,Molecular biology ,ADN ,Physiology ,CHILDREN ,3124 Neurology and psychiatry ,Epigenesis, Genetic ,Epigenome ,0302 clinical medicine ,Child ,RISK ,ASSOCIATION ,Middle Aged ,Justice and Strong Institutions ,Aggression ,Psychiatry and Mental health ,Schizophrenia ,TWINS ,Meta-analysis ,Cord blood ,Child, Preschool ,DNA methylation ,HEALTH ,medicine.symptom ,SMOKING ,Adult ,SDG 16 - Peace ,Adolescent ,515 Psychology ,Longevity ,Biology ,Article ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Young Adult ,SDG 3 - Good Health and Well-being ,Genetic variation ,medicine ,Genetics ,Humans ,ddc:610 ,EXPOSURE ,ABUSE ,Genetic association ,Aged ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,SDG 16 - Peace, Justice and Strong Institutions ,3112 Neurosciences ,GENOME-WIDE ,DNA Methylation ,Epigenètica ,medicine.disease ,3141 Health care science ,030104 developmental biology ,COHORT PROFILE ,1182 Biochemistry, cell and molecular biology ,CpG Islands ,3111 Biomedicine ,Metaanàlisi ,030217 neurology & neurosurgery ,Genome-Wide Association Study - Abstract
Molecular psychiatry 26(6), 2148-2162 (2021). doi:10.1038/s41380-020-00987-x, Published by Macmillan, London
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- 2021
48. Brain morphology, autistic traits, and polygenic risk for autism:A population-based neuroimaging study
- Author
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Alemany, Silvia, Blok, Elisabet, Jansen, Philip R., Muetzel, Ryan L., White, Tonya, Alemany, Silvia, Blok, Elisabet, Jansen, Philip R., Muetzel, Ryan L., and White, Tonya
- Abstract
Autism spectrum disorders (ASD) are associated with widespread brain alterations. Previous research in our group linked autistic traits with altered gyrification, but without pronounced differences in cortical thickness. Herein, we aim to replicate and extend these findings using a larger and older sample. Additionally, we examined whether (a) brain correlates of autistic traits were associated with polygenic risk scores (PRS) for ASD, and (b) autistic traits are related with brain morphological changes over time in a subset of children with longitudinal data available. The sample included 2400 children from the Generation R cohort. Autistic traits were measured using the Social Responsiveness Scale (SRS) at age 6 years. Gyrification, cortical thickness, surface area, and global morphological measures were obtained from high-resolution structural MRI scans at ages 9-to-12 years. We performed multiple linear regression analyses on a vertex-wise level. Corresponding regions of interest were tested for association with PRS. Results showed that autistic traits were related to (a) lower gyrification in the lateral occipital and the superior and inferior parietal lobes, (b) lower cortical thickness in the superior frontal region, and (c) lower surface area in inferior temporal and rostral middle frontal regions. PRS for ASD and longitudinal analyses showed significant associations that did not survive correction for multiple testing. Our findings support stability in the relationship between higher autistic symptoms and lower gyrification and smaller surface areas in school-aged children. These relationships remained when excluding ASD cases, providing neurobiological evidence for the extension of autistic traits into the general population. Lay Summary: We found that school-aged children with higher levels of autistic traits had smaller total brain volume, cerebellum, cortical thickness, and surface area. Further, we also found differences in the folding patterns of t
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- 2021
49. Brain morphology, autistic traits, and polygenic risk for autism: A population-based neuroimaging study
- Author
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Alemany, Silvia, Blok, Elisabet, Jansen, Philip R., Muetzel, Ryan L., White, Tonya, Alemany, Silvia, Blok, Elisabet, Jansen, Philip R., Muetzel, Ryan L., and White, Tonya
- Abstract
Autism spectrum disorders (ASD) are associated with widespread brain alterations. Previous research in our group linked autistic traits with altered gyrification, but without pronounced differences in cortical thickness. Herein, we aim to replicate and extend these findings using a larger and older sample. Additionally, we examined whether (a) brain correlates of autistic traits were associated with polygenic risk scores (PRS) for ASD, and (b) autistic traits are related with brain morphological changes over time in a subset of children with longitudinal data available. The sample included 2400 children from the Generation R cohort. Autistic traits were measured using the Social Responsiveness Scale (SRS) at age 6 years. Gyrification, cortical thickness, surface area, and global morphological measures were obtained from high-resolution structural MRI scans at ages 9-to-12 years. We performed multiple linear regression analyses on a vertex-wise level. Corresponding regions of interest were tested for association with PRS. Results showed that autistic traits were related to (a) lower gyrification in the lateral occipital and the superior and inferior parietal lobes, (b) lower cortical thickness in the superior frontal region, and (c) lower surface area in inferior temporal and rostral middle frontal regions. PRS for ASD and longitudinal analyses showed significant associations that did not survive correction for multiple testing. Our findings support stability in the relationship between higher autistic symptoms and lower gyrification and smaller surface areas in school-aged children. These relationships remained when excluding ASD cases, providing neurobiological evidence for the extension of autistic traits into the general population. Lay Summary: We found that school-aged children with higher levels of autistic traits had smaller total brain volume, cerebellum, cortical thickness, and surface area. Further, we also found differences in the folding patterns of t
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- 2021
- Full Text
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50. DNA methylation signatures of aggression and closely related constructs:A meta-analysis of epigenome-wide studies across the lifespan
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Hagenbeek, Fiona A., Suderman, Matthew, van Dongen, Jenny, Roetman, Peter J., Sugden, Karen, Chiocchetti, Andreas G., Ismail, Khadeeja, Mulder, Rosa H., Hafferty, Jonathan D., Adams, Mark J., Walker, Rosie M., Morris, Stewart W., Lahti, Jari, Küpers, Leanne K., Escaramis, Georgia, Alemany, Silvia, Jan Bonder, Marc, Meijer, Mandy, Ip, Hill F., Jansen, Rick, Baselmans, Bart M.L., Parmar, Priyanka, Lowry, Estelle, Streit, Fabian, Sirignano, Lea, Send, Tabea S., Frank, Josef, Jylhävä, Juulia, Wang, Yunzhang, Mishra, Pashupati Prasad, Colins, Olivier F., Felix, Janine F., Ligthart, Lannie, van Meurs, Joyce, Hottenga, Jouke J., van Duijn, Cornelia M., Hofman, Bert A., Isaacs, Aaron, Uitterlinden, André G., Verbiest, Michael, Verkerk, Marijn, van Rooij, Jeroen, van Dijk, Freerk, Tiemeier, Henning, van IJzendoorn, Marinus H., Bartels, Meike, Hagenbeek, Fiona A., Suderman, Matthew, van Dongen, Jenny, Roetman, Peter J., Sugden, Karen, Chiocchetti, Andreas G., Ismail, Khadeeja, Mulder, Rosa H., Hafferty, Jonathan D., Adams, Mark J., Walker, Rosie M., Morris, Stewart W., Lahti, Jari, Küpers, Leanne K., Escaramis, Georgia, Alemany, Silvia, Jan Bonder, Marc, Meijer, Mandy, Ip, Hill F., Jansen, Rick, Baselmans, Bart M.L., Parmar, Priyanka, Lowry, Estelle, Streit, Fabian, Sirignano, Lea, Send, Tabea S., Frank, Josef, Jylhävä, Juulia, Wang, Yunzhang, Mishra, Pashupati Prasad, Colins, Olivier F., Felix, Janine F., Ligthart, Lannie, van Meurs, Joyce, Hottenga, Jouke J., van Duijn, Cornelia M., Hofman, Bert A., Isaacs, Aaron, Uitterlinden, André G., Verbiest, Michael, Verkerk, Marijn, van Rooij, Jeroen, van Dijk, Freerk, Tiemeier, Henning, van IJzendoorn, Marinus H., and Bartels, Meike
- Abstract
DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta-analysis of epigenome-wide association studies (EWAS) of aggressive behavior (N = 15,324 participants). In peripheral blood samples of 14,434 participants from 18 cohorts with mean ages ranging from 7 to 68 years, 13 methylation sites were significantly associated with aggression (alpha = 1.2 × 10−7; Bonferroni correction). In cord blood samples of 2425 children from five cohorts with aggression assessed at mean ages ranging from 4 to 7 years, 83% of these sites showed the same direction of association with childhood aggression (r = 0.74, p = 0.006) but no epigenome-wide significant sites were found. Top-sites (48 at a false discovery rate of 5% in the peripheral blood meta-analysis or in a combined meta-analysis of peripheral blood and cord blood) have been associated with chemical exposures, smoking, cognition, metabolic traits, and genetic variation (mQTLs). Three genes whose expression levels were associated with top-sites were previously linked to schizophrenia and general risk tolerance. At six CpGs, DNA methylation variation in blood mirrors variation in the brain. On average 44% (range = 3–82%) of the aggression–methylation association was explained by current and former smoking and BMI. These findings point at loci that are sensitive to chemical exposures with potential implications for neuronal functions. We hope these results to be a starting point for studies leading to applications as peripheral biomarkers and to reveal causal relationships with aggression and related traits.
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- 2021
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