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将PSOD（等离子固态外部沉积）、光纤预制棒制备技术以及光纤拉丝技术相结合,成功开发了芯棒+天然石英砂套管的预制棒制备技术。该技术以成本相对较低的天然石英砂为原料,等离子体为热源,干燥压缩空气为工作气体,熔制了符合光纤生产要求的套管,并研究出了合适的光纤生产工艺路线。该套管的工艺路线简单,无需合成套管工艺中的脱水和烧结处理,且生产过程不会产生有毒有害的尾气,对环境无污染。针对天然石英砂材料的特殊性质,制定了低掺杂的预制棒沉积技术以及高张力拉丝的工艺条件,成品光纤各方面合格,并具有更低的衰耗。

BACKGROUND: Long intergenic non-protein coding RNA 00707 (LINC00707) and microRNA-423-5p (miR-423-5p) are both involved in the occurrence and development of osteoarthritis. Starbase predicts that LINC00707 and miR-423-5p have complementary sequences, but whether LINC00707 and miR-423-5p interact to regulate the progress of osteoarthritis still needs further research. OBJECTIVE: To investigate whether LINC00707 targets miR-423-5p to affect chondrocyte injury and inflammatory factor secretion in osteoarthritis. METHODS: Articular chondrocytes were divided into eight groups: (1) blank control group was given no treatment; (2) interleukin (IL)-1β group was cultured with 10 ng/mL IL-1β for 48 hours; (3) IL-1β+si-NC group was transfected with si-NC and then treated with 10 ng/mL IL-1β for 48 hours; (4) IL-1β+si-LINC00707 group was transfected with si-LINC00707 and then treated with 10 ng/mL IL-1β for 48 hours; (5) IL-1β+miR-NC group was transfected with miR-NC and then treated with 10 ng/mL IL-1β for 48 hours; (6) IL-1β+miR-423-5p group was transfected with miR-423-5p mimic and then treated with 10 ng/mL IL-1β for 48 hours; (7) IL-1β+si-LINC00707+anti-miR-NC group was co-transfected with si-LINC00707 and anti-miR-NC and then treated with 10 ng/mL IL-1β for 48 hours; (8) IL-1β+si-LINC00707+anti-miR-423-5p group was co-transfected with si-LINC00707 and anti-miR-423-5p and then treated with 10 ng/mL IL-1β for 48 hours. Relevant tests were performed at the end of the intervention. RESULTS AND CONCLUSION: Compared with the blank control group, the mRNA expression of LINC00707, apoptosis rate, protein expression of C-caspase3 and C-caspase9, and levels of tumor necrosis factor-α and IL-6 in articular chondrocytes were increased in the IL-1β group, while there was a decrease in miR-423-5p expression and IL-10 level (P < 0.05). Compared with the IL-1β group, the mRNA expression of LINC00707, apoptosis rate, protein expression of C-caspase3 and C-caspase9, and levels of tumor necrosis factor-α and IL-6 in articular chondrocytes were decreased in the IL-1β+si-LINC00707 group, while miR-423-5p expression and IL-10 level increased (P < 0.05). Compared with the IL-1β+miR-NC group, the protein expression of C-caspase3 and C-caspase9 and levels of tumor necrosis factor-α and IL-6 in articular chondrocytes were decreased in the IL-1β+miR-423-5p group, while miR-423-5p expression and IL-10 level increased (P < 0.05). Compared with the IL-1β+si-LINC00707+anti-miR-NC group, apoptosis rate, protein expression of C-caspase3 and C-caspase9, and levels of tumor necrosis factor-α and IL-6 in articular chondrocytes were increased in the IL-1β+si-LINC00707+anti-miR-423-5p group, while miR-423-5p expression and IL-10 level decreased (P < 0.05). To conclude, inhibiting LINC00707 by targeting miR-423-5p can reduce IL-1β-induced apoptosis and inflammation in articular chondrocytes. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the effect of transmembrane activator and calcium modulator cy- clophilin ligand interactor-immunoglobulin (TACI-Ig) on renal damage in rats with IgA nephropathy(IgAN). Methods A total of 24 SD rats were randomly divided into the normal control, the model, the TACI-Ig,and the drug control groups with six rats per group. The normal control and model groups received saline, the TACI-Ig group received TACI-Ig(14.36 mg/kg), and the drug control group received prednisolone acetate (5 mg/kg). Twenty-four-hour urinary protein (24h-UP), serum creatinine (Scr), blood urea nitrogen (BUN),ga- lactose-deficient IgA1 (Gd-IgA1), Toll-like receptor 4(TLR4), Myeloid differentiation factor 88 (MyD88), Nu- clear factor kapра В(NF-кВ) protein and mRNA levels were compared among groups to analyze the influence of TACI-Ig on renal damage. Results The 24h-UP levels in the model group were significantly higher than those in the normal control group, while levels in the TACI-Ig and drug control groups were significantly lower than those in the model group (P<0.05). Serum CRE levels in the TACI-Ig group were lower than those in the model group(P<0.05). Deposition of immune complexes in the mesangial area of renal tissues was significantly inhibited in the TACI-Ig and drug control groups. Serum Gd-IgAl levels in the model group were higher than those in the normal control group but lower than those in the TACI-Ig group (P<0.01). Se- rum Gd-IgAl levels in the drug control group were lower than those in the model group but higher than those in the TACI-Ig group (P<0.01). TLR4, MyD88, and NF-kB protein levels in the TACI-Ig group were lower than those in the model group(P<0.05). TLR4, MyD88 protein levels in the drug control group were higher than those in the TACI-Ig group (P<0.05). TLR4, MyD88, and NF-KB mRNA levels in the TACI-Ig group were lower than those in the model group (P<0.05). Conclusion TACI-Ig exhibits therapeutic efficacy in IgAN, improving renal function in rats and inhibiting mesangial matrix expansion and mesangial cell proliferation. [ABSTRACT FROM AUTHOR]

目的：观察五味甘露藏药药浴对脑卒中后伴肢体痉挛患者肌痉挛的影响。 方法：采用多中心, 随机对照的方法, 将来自16家国内三甲医院的558例脑卒中后伴肢体痉挛的患者随机分为五味 甘露藏药药浴组(279例)和康复对照组(279例)。两组均给予现代康复治疗, 五味甘露藏药药浴组在现代康复治疗 的基础上增加五味甘露藏药药浴治疗, 每天1次, 每周5次, 疗程均为4周。根据改良Ashworth评分, 将痉挛程度为 0—1级作为一组, 1+ —2级作为一组, 3—4级作为一组, 生成1*, 2*, 3*三个痉挛亚组。观察各亚组患者治疗前后改 良Ashworth痉挛评分变化。 结果：对于痉挛程度为1*(改良Ashworth 0—1级)的亚组, 治疗2周, 4周, 随访3个月, 6个月, 痉挛程度差异无显著 性意义(P>0.05)。对于痉挛程度为2*(改良Ashworth 1+ —2级)的亚组, 治疗2周, 4周, 随访3个月, 6个月, 痉挛程 度差异有显著性意义(P<0.05)。对于痉挛程度为3*(改良Ashworth 3—4级)的亚组, 大部分数据反映两组患者肌 痉挛情况与治疗起点相比, 差异无显著性意义(P>0.05)。 结论：五味甘露藏药药浴可改善脑卒中后伴肢体痉挛患者肌痉挛, 痉挛程度为1+ —2级的患者受益度最大。 [ABSTRACT FROM AUTHOR]

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To improve the present situation of border tourism in Dandong and facilitate the formation of festival and special event brands of the city, the authors explore the way for the interactive development between the border tourism and festival and special events. It is proposed that the city should integrate the existing festival and special events, improve the resident’s identity for festival and special events and emphasize the interactive development of them. [ABSTRACT FROM AUTHOR]

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To improve the present situation of border tourism in Dandong and facilitate the formation of festival and special event brands of the city, the authors explore the way for the interactive development between the border tourism and festival and special events. It is proposed that the city should integrate the existing festival and special events, improve the resident’s identity for festival and special events and emphasize the interactive development of them. [ABSTRACT FROM AUTHOR]

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