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An in-depth understanding of the associations between variations in the wetland area and socio-economic driving forces is essential owing to rapid urbanization. However, to date, no study has performed a quantitative study on the relationships between spatio-temporal patterns for wetland area variations and socio-economic driving factors in Yunnan Province. Based on Statistical Yearbook data, we found that during 10 years, different types of wetlands exhibited different change rates, with obvious spatial heterogeneity. The overall increase in wetland area in Yunnan Province was 13.35%, of which the increases in river, lake, and swamp wetland areas were 46.39%, −3.12%, and 295.56%, respectively. At the city level, the maximum decrease and increase in total wetland area were noted in Xishuangbanna (−84.30%) and Diqing (+185.22%), respectively. A total of 9 of 24 factors which were further selected according to collinearity diagnostics might help interpret changes in the wetland area of Yunnan Province according to the regression analysis results (R2 = 0.749, p < 0.01). Moreover, in different city development periods, the key socio-economic factors were different, which should be considered separately when formulating policies. Our results may clarify the socio-economic influencing factors for wetland spatio-temporal changes and help to guide policymakers. [ABSTRACT FROM AUTHOR]