1. Endocrine effects of methoxylated brominated diphenyl ethers in three in vitro models.
- Author
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Hu, Wei, Liu, Hongling, Sun, Hong, Shen, Ouxi, Wang, Xinru, Lam, Michael H.W., Giesy, John P., Zhang, Xiaowei, and Yu, Hongxia
- Subjects
PHENYL ethers ,ENDOCRINE system ,BIOTRANSFORMATION (Metabolism) ,ANCHOVIES ,REPORTER genes ,ANTIANDROGENS - Abstract
Abstract: Methoxylated brominated diphenyl ethers (MeO-BDEs) in aquatic environments have been found to be primarily of natural origin in the marine environment and not from biotransformation of synthetic PBDEs. Two of the eight MeO-PBDEs (2′-MeO-BDE-68 and 6-MeO-BDE-47) that were detected in anchovy from the Yangtze River Delta, were natural products from marine organisms. So 2′-MeO-BDE-68 and 6-MeO-BDE-47 were chosen to study the potential to modulate androgen, estrogen, or thyroid hormone receptor- (AR, ER, ThR) mediated responses by use of reporter gene assays. 2′-MeO-BDE-68 was antiandrogenic at 50μM, estrogenic at 10μM and antiestrogenic at 10 and 50μM (IC
50 =4.88μM). 2′-MeO-BDE-68 enhanced luciferase expression by 5nM T3 at 50μM. 6-MeO-BDE-47 exhibited potent antiandrogenicity at 1μM and greater (IC50 =41.8μM) and possessed estrogenic activity at 10μM and antiestrogenic activity at 10 and 50μM (IC50 =6.02μM). [Copyright &y& Elsevier]- Published
- 2011
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