Search

Objective: To investigate homocysteine (Hcy) and folate levels, prevalence of hyperhomocysteinaemia (HHcy) and folate deficiency, which are affected by lifestyles in urban, agricultural and stock-raising populations.Design: This is a cross-sectional study.Setting: Urban, agricultural and stock-raising regions in Emin, China.Participants: Totally 1926 subjects - 885 (45·9 %) from urban, 861 (44·7 %) from agricultural and 180 (9·4 %) from stock-raising regions - were obtained using multistage stratified random sampling. Inclusion criteria encompassed inhabitants aged ≥15 years who resided at the current address for ≥6 months and agreed to participate in the study. Surveys on health behaviour questionnaires and physical examinations were conducted and blood samples collected.Results: The folate level of subjects from the stock-raising region was the lowest, followed by those from the agricultural region, and the highest in those from the urban region (3·48 v. 6·50 v. 7·12 ng/ml, P < 0·001), whereas mean Hcy showed no significant difference across regions. The OR for HHcy in stock-raising regions was 1·90 (95 % CI 1·11, 3·27) compared with the urban region after adjusting for all possible covariates. The OR for folate deficiency in stock-raising and agriculture regions was 11·51 (95 % CI 7·09, 18·67) and 1·91 (95 % CI 1·30, 2·82), respectively, compared with the urban region after adjusting for all possible covariates.Conclusions: HHcy and folate deficiency are highly prevalent in stock-raisers, which is of important reference for HHcy control in Xinjiang, with a possibility of extension to others with approximate lifestyles. [ABSTRACT FROM AUTHOR]

Purpose: Credible data is scarce in representative population aged ≥18 years, though hypertension is highly prevalent and poorly controlled in population aged ≥30 years in Xinjiang Northwest China. Therefore, we tried to provide data on hypertension status for reference. Materials and methods: We conducted a population-based cross-sectional survey between 2014 and 2015 using stratified multi-stage random sampling as part of a national survey. Hypertension is defined as systolic blood pressure (BP) ≥140 mmHg, and/or diastolic BP ≥90 mmHg and/or taking anti-hypertensive agents. We assessed prevalence, awareness, treatment and control rates of hypertension by rural and urban regions, by gender and by ethnicity, and related factors including agent prescription pattern. Results: Data for 6807 subjects ≥18 years with 79.2% rural and 52.0% women subjects are analyzed. Overall age-adjusted prevalence of hypertension in population aged ≥18 years is 22.2%, and shows no disparity between genders and regions. By ethnicity, the prevalence of hypertension was the highest in Tajik subjects (25.4%), followed by Mongolian (25.3%) and Kazakh (24.8%) subjects and the lowest in Kyrgyz (20.2%) subjects. Of the hypertensives, 55.5% have awareness, 43.9% receive anti-hypertensive treatment, whereas only 14.5% have their BP controlled. In different ethnic groups, the awareness, control and control in treatment rates showed no significant disparities, except for the treatment rate. It was the highest in Kazakh subjects (50.0%) and the lowest in Hui subjects (36.7%). The most common prescribed agent encompassed ACEI/ARBs (41.1%) and calcium channel blockers (30.4%). Over 87.2% of hypertensives were prescribed for single drug regimen. Conclusions: Hypertension is moderately prevalent in Xinjiang, whereas poorly controlled. Standardization of its treatment such as introducing treatment algorithm might be the priorities for future improvement, with healthy life promotion. [ABSTRACT FROM AUTHOR]

Background To investigate the features of 24-hour urine and paired serum electrolytes in hypertensive patients with primary aldosteronism (PA). Methods A total of 764 hypertensive patients, who underwent PA screening and completed the measurement of 24-hour urine and paired serum electrolytes from January 2009 to January 2014 at the Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, were included. Of which, 135 patients were diagnosed with PA, whereas 629 patients were non-PA patients. Results Compared with the non-PA group, serum potassium (3.66 ± 0.41 vs. 3.86 ± 0.37 mmol/L), serum phosphorus (1.08 ± 0.16 vs. 1.16 ± 0.19 mmol/L), and calcium–phosphorus product (29.7 ± 5.2 vs. 32.4 ± 6.9 mg2/dL2) were lower in the PA group, while urine potassium (41.5, 31.6–52.4 vs. 35.9, 27.7–46.3 mmol/L), urine calcium (6.0, 4.5–8.1 vs. 5.2, 3.9–6.9 mmol/L), urine magnesium (3.8, 3.1–5.0 vs. 3.5, 2.7–4.6 mmol/L), the ratio of blood sodium to urine sodium divided by the ratio of blood potassium squared to urine potassium (SUSPPUP) (2.48, 1.71–3.95 vs. 1.96, 1.39–2.73) were higher in PA group (P < 0.01). Hypokalemia, hypocalcemia, urinary potassium > 54.1 mmol/L, urinary calcium > 7.5 mmol/L, and calcium–phosphorus product < 35 mg2/dL2 were more frequently observed in PA patients (P < 0.05). Conclusions In addition to hypokalemia and hypocalcemia, hypertensive patients with PA have higher urinary potassium, magnesium, calcium excretion but lower serum phosphorus. Their electrolyte characteristics show a higher SUSPPUP ratio and a lower calcium–phosphorus product. [ABSTRACT FROM AUTHOR]