1. Revealing fine-scale spatiotemporal differences in SARS-CoV-2 introduction and spread.
- Author
-
Moreno GK, Braun KM, Riemersma KK, Martin MA, Halfmann PJ, Crooks CM, Prall T, Baker D, Baczenas JJ, Heffron AS, Ramuta M, Khubbar M, Weiler AM, Accola MA, Rehrauer WM, O'Connor SL, Safdar N, Pepperell CS, Dasu T, Bhattacharyya S, Kawaoka Y, Koelle K, O'Connor DH, and Friedrich TC
- Subjects
- COVID-19, Coronavirus Infections prevention & control, Geography, Humans, Mass Screening methods, Molecular Epidemiology methods, Pandemics prevention & control, Pneumonia, Viral prevention & control, Psychological Distance, Respiratory Protective Devices, SARS-CoV-2, United States epidemiology, Wisconsin epidemiology, Betacoronavirus genetics, Coronavirus Infections epidemiology, Coronavirus Infections transmission, Genome, Viral genetics, Pneumonia, Viral epidemiology, Pneumonia, Viral transmission
- Abstract
Evidence-based public health approaches that minimize the introduction and spread of new SARS-CoV-2 transmission clusters are urgently needed in the United States and other countries struggling with expanding epidemics. Here we analyze 247 full-genome SARS-CoV-2 sequences from two nearby communities in Wisconsin, USA, and find surprisingly distinct patterns of viral spread. Dane County had the 12
th known introduction of SARS-CoV-2 in the United States, but this did not lead to descendant community spread. Instead, the Dane County outbreak was seeded by multiple later introductions, followed by limited community spread. In contrast, relatively few introductions in Milwaukee County led to extensive community spread. We present evidence for reduced viral spread in both counties following the statewide "Safer at Home" order, which went into effect 25 March 2020. Our results suggest patterns of SARS-CoV-2 transmission may vary substantially even in nearby communities. Understanding these local patterns will enable better targeting of public health interventions.- Published
- 2020
- Full Text
- View/download PDF