1. Excess mortality and tuberculosis among individuals with prolonged cough: a population-based study from Vietnam.
- Author
-
Hoa NP and Thorson AE
- Subjects
- Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Cough epidemiology, Cough microbiology, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Risk Factors, Rural Population statistics & numerical data, Sex Distribution, Socioeconomic Factors, Sputum microbiology, Tuberculosis, Pulmonary complications, Tuberculosis, Pulmonary epidemiology, Vietnam epidemiology, Cough mortality, Population Surveillance, Tuberculosis, Pulmonary mortality
- Abstract
Setting: A demographic surveillance site in north-west Vietnam., Objectives: To compare notification rates of sputum smear-positive tuberculosis (TB) and mortality rates between the general population and individuals with prolonged cough., Design: A cohort study of 559 prolonged cough cases in a total population of 35,832, observed over 2.5 years. Outcome measures were sputum smear-positive TB and death., Results: The age-standardised smear-positive TB notification rate among cough cases (553/100,000 person-years [py], 95%CI 268-1143) was significantly higher than in the general population (50/100,000 py, 95%CI 43-57), with a relative risk of 11.06 (95%CI 8.28-14.77). Among those who had a chest X-ray suggestive of TB but negative sputum smears prior to the study start, the rate was 6542/100,000 py (95%CI 2906-12,511). The cough cohort had a 2.61 (95%CI 2.38-2.87) times higher risk of dying than the general population., Conclusions: Individuals with prolonged cough in this study run a significantly increased risk of developing infectious TB and of dying. We recommend further evaluations of improved follow-up systems aimed at identifying and treating sputum smear-negative TB cases before they convert to an infectious stage.
- Published
- 2006