1. Isolation of three distinct carbapenemase-producing Gram-negative bacteria from a Vietnamese medical tourist.
- Author
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Honda NH, Aoki K, Kamisasanuki T, Matsuda N, To M, Matsushima H, Ishii Y, and Haruki K
- Subjects
- Bacterial Proteins metabolism, Carbapenem-Resistant Enterobacteriaceae drug effects, Carbapenem-Resistant Enterobacteriaceae genetics, Carbapenem-Resistant Enterobacteriaceae isolation & purification, Drug Resistance, Multiple, Bacterial genetics, Escherichia coli drug effects, Escherichia coli genetics, Escherichia coli isolation & purification, Gram-Negative Bacterial Infections diagnosis, Gram-Negative Bacterial Infections drug therapy, Humans, Japan, Klebsiella pneumoniae drug effects, Klebsiella pneumoniae genetics, Klebsiella pneumoniae isolation & purification, Male, Medical Tourism, Middle Aged, Plasmids genetics, Plasmids metabolism, Pseudomonas aeruginosa drug effects, Pseudomonas aeruginosa genetics, Pseudomonas aeruginosa isolation & purification, Vancomycin-Resistant Enterococci drug effects, Vancomycin-Resistant Enterococci genetics, Vancomycin-Resistant Enterococci isolation & purification, Vietnam, beta-Lactam Resistance genetics, beta-Lactamases metabolism, Bacterial Proteins genetics, Gram-Negative Bacterial Infections microbiology, beta-Lactamases genetics
- Abstract
Carbapenem-resistant Klebsiella pneumoniae and Escherichia coli, multidrug-resistant Pseudomonas aeruginosa and vancomycin-resistant Enterococcus faecium were isolated from a single patient. The patient came to Japan for advanced medical treatment after having undergone laparoscopic cholecystectomy and hospitalization in Vietnam. Whole-genome sequence analysis revealed that K. pneumoniae harbored bla
OXA-48 that was found on a Col156 -type small plasmid, E. coli harbored blaNDM-5 and P. aeruginosa harbored both blaNDM-1 and 16S rRNA methyltransferase (rmtB). To the best of our knowledge, this is the first report of detection of K. pneumoniae harboring blaOXA-48 on a Col156-type small plasmid in the world and P. aeruginosa coharboring genes encoding NDM-1 and RmtB in Japan., (Copyright © 2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)- Published
- 2019
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