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The problem of preserving the biological diversity of the Earth is attracting increasing attention of the world scientific community. Rare plant species, as the most vulnerable part of the flora, are under the greatest threat of extinction. In the study of this group of plants, population methods are increasingly being used. Revealing the number, structure, efficiency of self-renewal and resistance of populations of rare plants in relation to anthropogenic influences creates the basis for developing effective measures for their protection. The aim of the study was to assess the current state of coenopopulations of some rare endemic species – Acantholimon nuratavicum Zakirov ex Lincz. (Plumbaginaceae), Cousinia pseudolanata Popov ex Tscherneva (Asteraceae), Lepidolopha nuratavica Krasch. (Asteraceae) included in the Red Book of Uzbekistan. The results showed that in the ecological–coenotic conditions of the Navoi region, the studied coenopopulations are normal and incomplete. Ontogenetic spectra of coenopopulations are centred and left sided, with a peak for middle-aged and young generative individuals, which is associated with the ecological conditions of habitation and anthropogenic pressure. [ABSTRACT FROM AUTHOR]