1. Anthraquinones with quinone reductase-inducing activity and benzophenones from Morinda citrifolia (noni) roots.
- Author
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Deng Y, Chin YW, Chai H, Keller WJ, and Kinghorn AD
- Subjects
- Animals, Anthraquinones chemistry, Benzophenones chemistry, Mice, Molecular Structure, Plant Roots chemistry, Utah, Anthraquinones isolation & purification, Anthraquinones pharmacology, Benzophenones isolation & purification, Benzophenones pharmacology, Morinda chemistry, NAD(P)H Dehydrogenase (Quinone) antagonists & inhibitors, Plants, Medicinal chemistry
- Abstract
Two new benzophenones, morintrifolins A ( 1) and B ( 2), together with 14 known anthraquinones and four other known compounds, were isolated from a chloroform-soluble extract of Morinda citrifolia roots. Of the isolated compounds, four known anthraquinones, namely, 1,2-dihydroxyanthraquinone ( 3), 1,3-dihydroxy-2-methylanthraquinone ( 4), 2-hydroxy-3-(hydroxymethyl)anthraquinone ( 5), and 1,3,6-trihydroxy-2-methylanthraquinone ( 6), exhibited quinone reductase (QR)- inducing activity in Hepa lclc7 cells, with concentrations required to double QR activity of 12.0, 8.1, 0.94, and 0.56 microM, respectively.
- Published
- 2007
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