1. Anxiety, Depression, and Quality of Life After Procedural Intervention for Uterine Fibroids.
- Author
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Wallace, Kedra, Stewart, Elizabeth A., Wise, Lauren A., Nicholson, Wanda Kay, Parry, John Preston, Zhang, Shuaiqi, Laughlin-Tommaso, Shannon, Jacoby, Vanessa, Anchan, Raymond M., Diamond, Michael P., Venable, Sateria, Shiflett, Amber, Wegienka, Ganesa R., Maxwell, George Larry, Wojdyla, Daniel, Myers, Evan R., and Marsh, Erica
- Subjects
REPORTING of diseases ,UTERINE fibroids ,SURVEYS ,MENTAL depression ,QUALITY of life ,POSTOPERATIVE period ,QUESTIONNAIRES ,DESCRIPTIVE statistics ,ANXIETY ,DATA analysis software - Abstract
Background: Quality of life (QOL) and psychological health has been reported to be decreased among women with gynecological conditions such as uterine fibroids (UFs). Materials and Methods: Women enrolled in the Comparing Options for Management: PAtient-centered REsults for Uterine Fibroids (COMPARE-UF) registry, receiving procedural therapy for symptomatic UFs, were eligible for this analysis if they completed a series of health-related QOL surveys administered at three time points (baseline, 6–12 weeks postprocedure, and 1 year postprocedure; n = 1486). Ethical approval for this study was obtained at each recruiting site and the coordinating center (NCT02260752, clinicaltrials.gov). Results: More than 26% (n = 393) of women reported moderate anxiety/depression on the baseline anxiety/depression domain of the Euro-QOL 5-dimension instrument. At both the 6–12 weeks and 1-year postprocedural follow-up, there was significant improvement in the UF QOL symptom severity score (p < 0.001, p < 0.001), the total UF symptom QOL score (p < 0.001, p < 0.001), and the Euro-QOL 5-dimension visual analog scale (p < 0.001, p = 0.004) compared with the preprocedural baseline scores. The reporting of anxiety/depression decreased by 66.4% among women who were at baseline, whereas 5.6% of women previously reporting no anxiety/depression reported anxiety/depression at the 1-year follow-up. Conclusion: UF symptoms were more severe among women reporting anxiety/depression at baseline. At the 1-year follow-up, health-related QOL scores improved among all women and the prevalence of anxiety/depression decreased in most, but not all women, whereas severity of anxiety/depression worsened in a small percentage of women (5.6%). Overall, these results suggest that UF treatment improves symptoms of anxiety/depression associated with symptomatic UFs. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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