1. COVID-19: Understanding the science of antibody testing and lessons from the HIV epidemic.
- Author
-
Weiss SH and Wormser GP
- Subjects
- Antibodies, Viral blood, COVID-19, COVID-19 Testing, Coronavirus Infections immunology, HIV Infections immunology, Humans, Pandemics, Pneumonia, Viral immunology, SARS-CoV-2, Sensitivity and Specificity, United States, United States Food and Drug Administration standards, Antibodies, Viral immunology, Betacoronavirus immunology, Clinical Laboratory Techniques methods, Coronavirus Infections diagnosis, HIV Infections diagnosis, Pneumonia, Viral diagnosis
- Abstract
Potential pitfalls in the development, deployment and interpretation of antibody tests for COVID-19 are discussed. Lessons learned from the experience with the introduction of antibody tests for HIV are highlighted.Each test will need to be separately vetted for performance and clinical implementation based upon rigorous clinical trial data. The issues we highlight will also be similarly important for vaccine and therapeutic drug efficacy trials., Competing Interests: Disclosures Dr. Weiss is an unpaid member of the executive board of the New Jersey Public Health Association, and chair of its Epidemiology Section. Dr. Wormser reports receiving research grants from Immunetics, Inc., Institute for Systems Biology, Rarecyte, Inc., and Quidel Corporation. He owns equity in Abbott/AbbVie; has been an expert witness in malpractice cases involving Lyme disease; and is an unpaid board member of the American Lyme Disease Foundation., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
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